Lithium Sulfate
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Lithium Carbonate
Right to Know Hazardous Substance Fact Sheet Common Name: LITHIUM CARBONATE Synonyms: Dilithium Carbonate; Carbolith CAS Number: 554-13-2 Chemical Name: Carbonic Acid, Dilithium Salt RTK Substance Number: 1124 Date: September 1998 Revision: January 2008 DOT Number: None Description and Use EMERGENCY RESPONDERS >>>> SEE BACK PAGE Lithium Carbonate is a white, light, odorless powder. It is Hazard Summary used in the production of glazes on ceramics and porcelain, in Hazard Rating NJDOH NFPA varnishes and dyes, as a coating on arc welding electrodes, HEALTH 1 - and in lubricating greases. It is also used as medication to FLAMMABILITY 0 - treat certain types of mental illness. REACTIVITY 0 - TERATOGEN POISONOUS GASES ARE PRODUCED IN FIRE Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious; 4=severe Reasons for Citation f Lithium Carbonate is on the Right to Know Hazardous f Lithium Carbonate can affect you when inhaled. Substance List because it is cited by DEP and EPA. f Lithium Carbonate may be a TERATOGEN. HANDLE f This chemical is on the Special Health Hazard Substance List. WITH EXTREME CAUTION. f Contact can irritate the skin and eyes. f Inhaling Lithium Carbonate can irritate the nose and throat. f Lithium Carbonate can cause nausea, vomiting, diarrhea and abdominal pain. f Inhaling Lithium Carbonate can irritate the lungs. Higher exposures may cause a build-up of fluid in the lungs SEE GLOSSARY ON PAGE 5. (pulmonary edema), a medical emergency. f Lithium Carbonate can cause headache, muscle FIRST AID weakness, confusion, seizures and coma. Eye Contact f Lithium Carbonate may cause a skin allergy. -
Lithium Carbonate
SAFETY DATA SHEET Creation Date 26-Sep-2009 Revision Date 18-Jan-2018 Revision Number 3 1. Identification Product Name Lithium Carbonate Cat No. : L119-500 CAS-No 554-13-2 Synonyms carbonic acid lithium salt; Carbonic Acid Dilithium Salt Recommended Use Laboratory chemicals. Uses advised against Not for food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet Company Fisher Scientific One Reagent Lane Fair Lawn, NJ 07410 Tel: (201) 796-7100 Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300 CHEMTRECÒ, Outside the USA: 001-703-527-3887 2. Hazard(s) identification Classification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) Acute oral toxicity Category 4 Skin Corrosion/irritation Category 2 Serious Eye Damage/Eye Irritation Category 1 Specific target organ toxicity (single exposure) Category 3 Target Organs - Respiratory system, Central nervous system (CNS). Label Elements Signal Word Danger Hazard Statements Harmful if swallowed Causes skin irritation Causes serious eye damage May cause respiratory irritation ______________________________________________________________________________________________ Page 1 / 7 Lithium Carbonate Revision Date 18-Jan-2018 ______________________________________________________________________________________________ Precautionary Statements Prevention Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product Wear protective gloves/protective clothing/eye protection/face protection Avoid breathing dust/fume/gas/mist/vapors/spray Use only outdoors or in a well-ventilated area Inhalation IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing Call a POISON CENTER or doctor/physician if you feel unwell Skin IF ON SKIN: Wash with plenty of soap and water If skin irritation occurs: Get medical advice/attention Take off contaminated clothing and wash before reuse Eyes IF IN EYES: Rinse cautiously with water for several minutes. -
A Study of Lithium Precursors on Nanoparticle Quality
Electronic Supplementary Material (ESI) for Nanoscale. This journal is © The Royal Society of Chemistry 2021 Electronic Supplementary Information Elucidating the role of precursors in synthesizing single crystalline lithium niobate nanomaterials: A study of lithium precursors on nanoparticle quality Rana Faryad Ali, Byron D. Gates* Department of Chemistry and 4D LABS, Simon Fraser University, 8888 University Drive Burnaby, BC, V5A 1S6, Canada * E-mail: [email protected] This work was supported in part by the Natural Sciences and Engineering Research Council of Canada (NSERC; Grant No. RGPIN-2020-06522), and through the Collaborative Health Research Projects (CHRP) Partnership Program supported in part by the Canadian Institutes of Health Research (Grant No. 134742) and the Natural Science Engineering Research Council of Canada (Grant No. CHRP 462260), the Canada Research Chairs Program (B.D. Gates, Grant No. 950-215846), CMC Microsystems (MNT Grant No. 6345), and a Graduate Fellowship (Rana Faryad Ali) from Simon Fraser University. This work made use of 4D LABS (www.4dlabs.com) and the Center for Soft Materials shared facilities supported by the Canada Foundation for Innovation (CFI), British Columbia Knowledge Development Fund (BCKDF), Western Economic Diversification Canada, and Simon Fraser University. S1 Experimental Materials and supplies All chemicals were of analytical grade and were used as received without further purification. Niobium ethoxide [Nb(OC2H5)5, >90%] was obtained from Gelest Inc., and benzyl alcohol (C7H7OH, 99%) and triethylamine [N(C2H5)3, 99.0%] were purchased from Acros Organics and Anachemia, respectively. Lithium chloride (LiCl, ~99.0%) was obtained from BDH Chemicals, and lithium bromide (LiBr, ≥99.0%), lithium fluoride (LiF, ~99.9%), and lithium iodide (LiI, 99.0%) were purchased from Sigma Aldrich. -
Management and Treatment of Lithium-Induced Nephrogenic Diabetes Insipidus
REVIEW Management and treatment of lithium- induced nephrogenic diabetes insipidus Christopher K Finch†, Lithium carbonate is a well documented cause of nephrogenic diabetes insipidus, with as Tyson WA Brooks, many as 10 to 15% of patients taking lithium developing this condition. Clinicians have Peggy Yam & Kristi W Kelley been well aware of lithium toxicity for many years; however, the treatment of this drug- induced condition has generally been remedied by discontinuation of the medication or a †Author for correspondence Methodist University reduction in dose. For those patients unresponsive to traditional treatment measures, Hospital, Department several pharmacotherapeutic regimens have been documented as being effective for the of Pharmacy, University of management of lithium-induced diabetes insipidus including hydrochlorothiazide, Tennessee, College of Pharmacy, 1265 Union Ave., amiloride, indomethacin, desmopressin and correction of serum lithium levels. Memphis, TN 38104, USA Tel.: +1 901 516 2954 Fax: +1 901 516 8178 [email protected] Lithium carbonate is well known for its wide use associated with a mutation(s) of vasopressin in bipolar disorders due to its mood stabilizing receptors. Acquired causes are tubulointerstitial properties. It is also employed in aggression dis- disease (e.g., sickle cell disease, amyloidosis, orders, post-traumatic stress disorders, conduct obstructive uropathy), electrolyte disorders (e.g., disorders and even as adjunctive therapy in hypokalemia and hypercalcemia), pregnancy, or depression. Lithium has many well documented conditions induced by a drug (e.g., lithium, adverse effects as well as a relatively narrow ther- demeclocycline, amphotericin B and apeutic range of 0.4 to 0.8 mmol/l. Clinically vincristine) [3,4]. Lithium is the most common significant adverse effects include polyuria, mus- cause of drug-induced nephrogenic DI [5]. -
Subchronic Lithium Treatment Increases the Anxiolytic-Like Effect of Mirtazapine on the Expression of Contextual Title Conditioned Fear
Subchronic lithium treatment increases the anxiolytic-like effect of mirtazapine on the expression of contextual Title conditioned fear Author(s) An, Yan; Inoue, Takeshi; Kitaichi, Yuji; Nakagawa, Shin; Wang, Ce; Chen, Chong; Song, Ning; Kusumi, Ichiro European journal of pharmacology, 747, 13-17 Citation https://doi.org/10.1016/j.ejphar.2014.11.009 Issue Date 2015-01-15 Doc URL http://hdl.handle.net/2115/58243 Type article (author version) File Information AnManuscript.pdf Instructions for use Hokkaido University Collection of Scholarly and Academic Papers : HUSCAP Subchronic lithium treatment increases the anxiolytic-like effect of mirtazapine on the expression of contextual conditioned fear Yan Ana, Takeshi Inouea*, Yuji Kitaichia, Shin Nakagawaa, Ce Wangb, Chong Chena, Ning Songa, Ichiro Kusumia a Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan b Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan Number of figures: 3 Corresponding address: Takeshi Inoue, Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan Phone: +81(11)706-5160 Fax: +81(11)706-5081 E-mail: [email protected] 1 Abstract Lithium not only has a mood-stabilizing effect but also the augmentation effect of an antidepressant, the mechanism of which remains unclear. Although lithium may augment the effect of mirtazapine, this augmentation has not been confirmed. Using a contextual fear conditioning test in rats, an animal model of anxiety or fear, we examined the effect of subchronic lithium carbonate (in diet) in combination with systemic mirtazapine on the expression of contextual conditioned fear. -
(12) Patent Application Publication (10) Pub. No.: US 2005/0158383 A1 B0ehm Et Al
US 2005O158383A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2005/0158383 A1 B0ehm et al. (43) Pub. Date: Jul. 21, 2005 (54) QUETIAPINE FORMULATIONS (52) U.S. Cl. ..................... 424/468; 424/484; 514/211.13 (76) Inventors: Garth Boehm, Westfield, NJ (US); Josephine Dundon, Fanwood, NJ (US) (57) ABSTRACT Correspondence Address: CANTOR COLBURN, LLP 55 GRIFFINROAD SOUTH The invention provides novel dosage forms of quetiapine BLOOMFIELD, CT 06002 and its Salts, particularly quetiapine hemifumarate including wax dosage forms, preSS-coat dosage forms, and Sprinkle (21) Appl. No.: 10/970,850 dosage forms, and other novel dosage forms. The invention (22) Filed: Oct. 21, 2004 also provides Sustained release and pulsed release dosage forms of quetiapine and its Salts. Related U.S. Application Data Methods of making novel quetiapine dosage forms are (60) Provisional application No. 60/513,461, filed on Oct. given. 21, 2003. Methods of treating Schizophenia and other neuropsychiatric Publication Classification disorders by administering an effective amount of the dosage forms disclosed herein, either alone or in combination with 51) Int.nt. Cl.C.7 ......................... A61K 3.11554; A61K 9/48 one or more other medicaments, are also provided by the A61K 9/22; A61K 9/14 invention US 2005/0158383 A1 Jul. 21, 2005 QUETIAPINE FORMULATIONS Also, the dosage form can be undesirably large when quetiapine is combined with other active agents, especially CROSS-REFERENCE TO RELATED other high dose active agents. The large Size of these dosage APPLICATION forms can be difficult for patients, especially elderly patients, to Swallow. Further, large dosage form Size may 0001. -
Lithium Sulfate, Technical Grade, Min. 99.0 %
TECHNICAL DATA SHEET Date of Issue: 2018/02/15 Lithium Sulfate, technical grade, min. 99.0 % CAS-No. 10377-48-7 EC-No. 233-820-4 REACH No. 01-2119968668-14 Molecular Formula Li2O4S Product Number 401142 APPLICATION Additive for manufacturing special glass mixtures. Used for marking of chemical products. Additive in the building material industry. SPECIFICATION Li2SO4 min 99.0 % H2O (105 °C) max. 0.4 % Na max. 0.1 % K max. 0.05 % Fe max. 0.002 % Mg max. 0.01 % Heavy metals (as Pb) max. 0.004 % PHYSICAL PROPERTIES Appearance crystalline Color colorless to white Melting point/ range 860 °C Density 2.2 g/cm3 at 20 °C Bulk density ca. 800 kg/m3 Water solubility 342 g/L at 25 °C The information presented herein is believed to be accurate and reliable, but is presented without guarantee or responsibility on the part of Albemarle Corporation and its subsidiaries and affiliates. It is the responsibility of the user to comply with all applicable laws and regulations and to provide for a safe workplace. The user should consider any health or safety hazards or information contained herein only as a guide, and should take those precautions which are necessary or prudent to instruct employees and to develop work practice procedures in order to promote a safe work environment. Further, nothing contained herein shall be taken as an inducement or recommendation to manufacture or use any of the herein materials or processes in violation of existing or future patent. Technical data sheets may change frequently. You can download the latest version from our website www.albemarle-lithium.com. -
Disease-Modifying Properties of Long-Term Lithium Treatment for Amnestic Mild Cognitive Impairment: Randomised Controlled Trial{ Orestes V
The British Journal of Psychiatry (2011) 198, 351–356. doi: 10.1192/bjp.bp.110.080044 Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial{ Orestes V. Forlenza, Breno S. Diniz, Ma´ rcia Radanovic, Franklin S. Santos, Leda L. Talib and Wagner F. Gattaz Background Two recent clinical studies support the feasibility of trials biomarkers (amyloid-beta peptide (Ab42), total tau (T-tau), to evaluate the disease-modifying properties of lithium in phosphorylated-tau) (P-tau). Trial registration: NCT01055392. Alzheimer’s disease, although no benefits were obtained from short-term treatment. Results Lithium treatment was associated with a significant decrease in CSF concentrations of P-tau (P = 0.03) and Aims better perform-ance on the cognitive subscale of the To evaluate the effect of long-term lithium treatment on Alzheimer’s Disease Assessment Scale and in attention tasks. cognitive and biological outcomes in people with amnestic Overall tolerability of lithium was good and the adherence mild cognitive impairment (aMCI). rate was 91%. Conclusions Method The present data support the notion that lithium has Forty-five participants with aMCI were randomised to receive disease-modifying properties with potential clinical lithium (0.25–0.5 mmol/l) (n = 24) or placebo (n = 21) in a implications in the prevention of Alzheimer’s disease. 12-month, double-blind trial. Primary outcome measures were the modification of cognitive and functional test Declaration of interest scores, and concentrations of cerebrospinal fluid (CSF) None. Lithium salts have been extensively used in the past decades for safe. Nevertheless, no cognitive benefits were observed among the treatment of bipolar disorder and major depression. -
Endocrine Emergencies
Endocrine Emergencies • Neuroendocrine response to Critical illness • Thyroid storm/Myxedema Coma • Adrenal Crisis/Sepsis • Hyper/Hypocalcemia • Hypoglycemia • Hyper and Hyponatremia • Pheochromocytoma crises CASE 76 year old man presents with urosepsis and is Admitted to MICU. He has chronic renal insufficiency. During his hospital course, he is intubated and treated With dopamine. Thyroid studies are performed for Inability to wean from ventilator. What labs do you want? Assessment of Thyroid Function • Hormone Levels: Total T4, Total T3 • Binding proteins: TBG, (T3*) Resin uptake • Free Hormone Levels: TSH, F T4, F T3, Free Thyroid Index, F T4 by Eq Dialysis • Radioactive Iodine uptake (RAIU); primarily for DDx of hyperthyroidism • Thyroid antibodies; TPO, Anti-Thyroglobulin, Thyroid stimulating immunoglobulins, Th receptor antibodies Labs: T4 2.4 ug/dl (5-12) T3U 40% (25-35) FTI 1.0 (1.2-4.2) FT4 0.6 (0.8-1.8) TSH 0.2 uU/ml (.4-5.0) Non-thyroidal illness • Hypothesis: NTI vs 2° Hypothyroidism –RT3 ↑ in NTI and ↓ in Hypothyroidism • Hypothesis: NTI vs Hyperthyroidism – TT3 ↓ in NTI and in ↑ Hyperthyroidism • 75 year old woman with history of hypothyroidism is found unresponsive in her home during a cold spell in houston. No heat in the home. • Exam: T° 95, BP 100/60, P 50, RR 8 • Periorbital edema, neck scar, no rub or gallop, distant heart sounds, crackles at bases, peripheral edema • ECG: Decreased voltage, runs of Torsade de pointes • Labs? Imaging? • CXR: cardiomegaly • Glucose 50 • Na+ 120, K+ 4, Cl 80, HCO3¯ 30 • BUN 30 Creat 1.4 • ABG: pH 7.25, PCO2 75, PO2 80 • CK 600 • Thyroid studies pending • Management: Manifestations of Myxedema Coma • Precipitated by infection, iatrogenic (surgery, sedation, diuretics) • Low thyroid studies • Hypothermia • Altered mental status • Hyponatremia • ↑pCO2 • ↑CK • ↑Catecholamines with ↑vascular resistance • Cardiac: low voltage, Pericardial effusion, impaired relaxation with ↓C.O. -
Beyond Lithium in the Treatment of Bipolar Illness Robert M
Beyond Lithium in the Treatment of Bipolar Illness Robert M. Post, M.D., Mark A. Frye, M.D., Kirk D. Denicoff, M.D., Gabriele S. Leverich, L.C.S.W., Tim A. Kimbrell, M.D., and Robert T. Dunn, M.D. Dramatic changes have recently occurred in the availability lamotrigine, gabapentin, and topiramate have unique of treatment options for bipolar illness. Second generation mechanisms of action and deserve further systematic study, mood stabilizing anticonvulsants carbamazepine and as does the potential role for nonconvulsive brain valproate are now widely used as alternatives or adjuncts to stimulation with repeated transcranial magnetic lithium. High potency benzodiazepines are also used as stimulation (rTMS). These and a host of other potential alternatives to typical neuroleptics, and now atypical treatment options now require a new generation of clinical neuroleptics are demonstrating efficacy and better side- trials to help identify clinical and biological markers of effects profiles than the typicals. Thyroid augmentation response and optimal use alone and in complex combination strategies and dihydropyridine L-type calcium channel therapeutic regimens. [Neuropsychopharmacology blockers require further clinical trials to define their role. 19:206–219, 1998] Published by Elsevier Science Inc. Putative third generation mood stabilizing anticonvulsants KEY WORDS: Carbamazepine; Valproate; Calcium channel al. 1989; O’Connell et al. 1991; Denicoff et al. 1997); a blockers; Lamotrigine; Gabapentin; rTMS history of co-morbid substance abuse; and those pa- tients with a history of head trauma or other such medi- There is increasing recognition of the inadequacy of cal co-morbidities as multiple sclerosis, etc. “lithium treatment” in bipolar illness, even with ad- In addition, it is recognized that patients with initial junctive antidepressants and neuroleptics (Maj et al. -
Disease-Modifying Properties of Long-Term Lithium Treatment for Amnestic Mild Cognitive Impairment: Randomised Controlled Trial{ Orestes V
The British Journal of Psychiatry (2011) 198, 351–356. doi: 10.1192/bjp.bp.110.080044 Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial{ Orestes V. Forlenza, Breno S. Diniz, Ma´ rcia Radanovic, Franklin S. Santos, Leda L. Talib and Wagner F. Gattaz Background Two recent clinical studies support the feasibility of trials biomarkers (amyloid-beta peptide (Ab42), total tau (T-tau), to evaluate the disease-modifying properties of lithium in phosphorylated-tau) (P-tau). Trial registration: NCT01055392. Alzheimer’s disease, although no benefits were obtained from short-term treatment. Results Lithium treatment was associated with a significant decrease in CSF concentrations of P-tau (P = 0.03) and Aims better perform-ance on the cognitive subscale of the To evaluate the effect of long-term lithium treatment on Alzheimer’s Disease Assessment Scale and in attention tasks. cognitive and biological outcomes in people with amnestic Overall tolerability of lithium was good and the adherence mild cognitive impairment (aMCI). rate was 91%. Conclusions Method The present data support the notion that lithium has Forty-five participants with aMCI were randomised to receive disease-modifying properties with potential clinical lithium (0.25–0.5 mmol/l) (n = 24) or placebo (n = 21) in a implications in the prevention of Alzheimer’s disease. 12-month, double-blind trial. Primary outcome measures were the modification of cognitive and functional test Declaration of interest scores, and concentrations of cerebrospinal fluid (CSF) None. Lithium salts have been extensively used in the past decades for safe. Nevertheless, no cognitive benefits were observed among the treatment of bipolar disorder and major depression. -
Side Effects and Toxicity of Lithium
Side Effects and Toxicity of Lithium Jeffrey T. Apter, MD, Alan S. Apter, MD, and S. Tyano, MD Belle Mead, New Jersey, and Tel Aviv, Israel Although lithium remains the most specific treatment for bipo lar affective disorder, it should be cautiously prescribed and used only when clinically indicated. The main indications for lithium are the manic phase of bipolar affective disorder and prophylaxis of both manic and depressive episodes. Lowering serum lithium levels will markedly reduce the incidence of side effects, and patients should be maintained at the lowest possi ble serum level. The serum level may be as low as 0.4 mEq/L and as high as 1.5 mEq/L, depending on the clinical response of the patient and the presence of side effects. The most contro versial areas are the possibility of renal toxicity and the concomi tant use of lithium with neuroleptics, especially haloperidol. In addition to its well-studied use in affective poisoning and serious adverse reactions. Current disorders, lithium has been used in at least 30 recommendations include monitoring kidney func other psychiatric and nonpsychiatric conditions.1,2 tioning, at least with serial creatinines and general Even within the therapeutic serum lithium range, chemistry, and monitoring thyroid functions with as many as two thirds of patients suffer from per a thyroid-stimulating hormone (TSH) level every sistent, unwanted side effects.3 In addition, the six months. concomitant use of other drugs, the presence of Patients taking other medication, especially di other disease states, and special physiological uretics and neuroleptics, should be followed par states, such as pregnancy, must also be considered ticularly closely to prevent the possibility of lith as potentially inducing lithium side effects.4 ium toxicity.