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Autism and Measles-Mumps-Rubella Vaccination Controversy Laid to Rest?
CNS Drugs 2001; 15 (11): 831-837 CURRENT OPINION 1172-7047/01/0011-0831/$22.00/0 © Adis International Limited. All rights reserved. Autism and Measles-Mumps-Rubella Vaccination Controversy Laid to Rest? Frank DeStefano1 and Robert T. Chen2 1 National Center on Birth Defects and Developmental Disabilities, Atlanta, Georgia, USA 2 National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Abstract It has been suggested that vaccination, particularly with measles-mumps-ru- bella (MMR) vaccine, may be related to the development of autism. The main evidence for a possible association is that the prevalence of autism has been increasing at the same time that infant vaccination coverage has increased, and that in some cases there is an apparent temporal association in which autistic characteristics are first noted shortly after vaccination. Although the prevalence of autism and similar disorders appears to have increased recently, it is not clear if this is an actual increase or the result of increased recognition and changes in diagnostic criteria. The apparent onset of autism in close proximity to vaccination may be a coincidental temporal association. The clinical evidence in support of an association derives from a series of 12 patients with inflammatory bowel conditions and regressive developmental disorders, mostly autism. The possibil- ity that measles vaccine may cause autism through a persistent bowel infection has generated much interest, since it provides a possible biological mechanism. Epidemiological studies, however, have not found an association between MMR vaccination and autism. The epidemiological findings are consistent with current understanding of the pathogenesis of autism, which has a strong genetic compo- nent and in which the neurological defects probably occur early in embryonic development. -
Ireland Conference Kristallnacht: the Night of Broken Glass
New Rochelle U.S. - Ireland Senior Action Candidates Page 4 Conference Page 4 Page 8 VWESTCHESTEROLUME 2 • NUMBER 61 Your World, Our Beat; TIMES Now You Know!™ TRIBUNENOVEMBER 1, 2007 www.WestchesterTimesTribune.Typepad.com Complimentary Kristallnacht: The Night of Broken Glass Ninety Jews were killed, 500 synagogues were burned and most Jewish shops had their windows smashed Years of pent-up hatred in Herschel Grynszpan shot and killed an excuse to conduct the first State- hauled off to concentration camps. very often been a prophet, and the leadership of the State, and with Germany, toward the Jews was Ernst vom Rath, a German embassy run pogrom against Jews. Ninety As a kind of cynical joke, the have usually been ridiculed for it. it that of the whole nation, and that finally let loose on the night that official in Paris, in protest of his Jews were killed, 500 synagogues Nazis then fined the Jews 1 Billion During the time of my struggle for I would then among other things marks the actual beginning of the family’s deportation from Germany were burned and most Jewish Reichsmarks for the destruction power it was in the first instance settle the Jewish problem. Their Holocaust. The Night of Broken to Poland. shops had their windows smashed. which the Nazis themselves had only the Jewish race that received laughter was uproarious, but I think Glass (Kristallnacht) occurred on Spurred on by Joseph Goebbels, The first mass arrest of Jews also caused during Kristallnacht. my prophecies with laughter when that for some time now they have Nazis used the death of vom Rath as occurred as over 25,000 men were “In the course of my life I have I said that I would one day take over November 9/10 after 17-year-old see Kristallnacht Pg. -
Department of Health and Human Services Centers for Disease Control and Prevention
DEPARTMENT OF HEALTH AND HUMAN SERVICES CENTERS FOR DISEASE CONTROL AND PREVENTION Advisory Committee on Immunization Practices (ACIP) Summary Report June 23-24, 2010 Atlanta, Georgia Advisory Committee on Immunization Practices (ACIP) Summary Report June 23-24, 2010 Table of Contents Page Agenda 4-5 Acronyms 6-8 Wednesday, June 23 Welcome and Introductions 9-14 Evidence-Based Recommendations Work Group Introduction: ACIP Implementation of an Explicit Evidence-Based Recommendations Format Professional Organization Perspectives on Development and Endorsement of Recommendations 14-45 GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) WHO’s Strategic Advisory Group of Experts (SAGE): Approach to Evidence-Based Framework Based on GRADE Meningococcal Vaccine Introduction Guillain-Barre Syndrome (GBS) After Receipt of Menactra 46-73 Update on Monitoring of GBS after Receipt of Meningococcal Conjugate Vaccines Meningococcal Conjugate Vaccines and BGS Update on Meningococcal Vaccination Programs Human Papillomavirus (HPV) Vaccines 73-75 HPV Vaccine Update Hepatitis Vaccines Update on Hepatitis Vaccines Work Group Trends in Acute Hepatitis B Virus (HBV) Disease 75-100 Hepatitis B Risk Among Persons With and Without Diabetes Mellitus Hepatitis B Vaccine Safety and Seroprotection Rates Among Persons with Diabetes Mellitus Preview of Proposed Recommendations; Request for Additional Information Pertussis Vaccines Update on Pertussis Vaccines Work Group Activities 100-109 Update on the Pertussis Vaccine Program 13-Valent Pneumococcal -
Vaccine Safety Quarterly (VSQ) | Fall 2020
Vaccine Safety Quarterly (VSQ) | Fall 2020 Brighton Collaboration 2.0 Frederick Varricchio, PhD, MD - Editor in Chief The Brighton Collaboration Standardized Templates for Collection of Key Information for Benefit-Risk Assessment of Vaccines by Technology (BRAVATO; formerly V3SWG) Safe and effective vaccines against SARS-CoV-2 are The Brighton Collaboration’s BRAVATO (Benefit-Risk widely seen as the best long term solution for the Assessment of Vaccines by Technology), formerly the COVD-19 pandemic. As of September 4, 2020, 234 Viral Vector Vaccines Safety or V3SWG, Working COVID-19 vaccines are currently under Group has developed standard templates for benefit- development, 31 of which are in Phase 1 or Phase 2 risk assessment of vaccine technologies for the main human trials and eight in Phase 3. The remainder are COVID-19 platforms. The templates aim to increase in preclinical studies. The candidate vaccines use a the comparability and transparency of information, wide range of both established and novel provide a checklist-like tool for managing potential technologies. Established technologies comprise complex risks, and increase scientific literacy and those for which successful human vaccines exist and discussion among stakeholders of otherwise highly include inactivated whole virus, live attenuated virus, technical information. viral vectored or antigenic viral proteins produced by The nucleic acid (DNA and RNA), protein, and recombinant DNA technology. Novel technologies include platforms for which no licensed human inactivated viral vector vaccines templates have been recently published in Vaccine, a nd the vaccines exist, including nucleic acid (RNA and DNA) vaccines. Several vaccines using these novel templates for viral vector vaccines (Version 2.0), and technologies are among the most advanced of the live attenuated viral vaccines will be published in the COVID19 vaccine candidates, already in Phase 2 or 3 near future. -
Front Matter
Cambridge University Press 978-1-108-41829-4 — My Opposition Friedrich Kellner , Edited and translated by Robert Scott Kellner Frontmatter More Information MY OPPOSITION This is a truly unique account of Nazi Germany at war and of one man’s struggle against totalitarianism. A mid-level official in a provincial town, Friedrich Kellner kept a secret diary from 1939 to 1945, risking his life to record Germany’s path to dictatorship and genocide and to protest his countrymen’s complicity in the regime’s brutalities. Just one month into the war he is aware that Jews are marked for extermination and later records how soldiers on leave spoke openly about the mass murder of Jews and the murder of POWs; he also documents the Gestapo’s merciless rule at home from euthanasia campaigns against the handicapped and mentally ill to the execution of anyone found listening to foreign broadcasts. This essential testimony of everyday life under the Third Reich is accompanied by a foreword by Alan Steinweis and the remarkable story of how the diary was brought to light by Robert Scott Kellner, Friedrich’s grandson. Robert Scott Kellner discovered his grandfather’s diary in 1960 and has worked tirelessly to bring it to the attention of the world through exhibits at the Dwight D. Eisenhower and George H. W. Bush Presidential Libraries, a documentary film screened at the United Nations, and the publication of a complete edition of the diary in German and abridgments in Russian and Polish. © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-1-108-41829-4 — My Opposition Friedrich Kellner , Edited and translated by Robert Scott Kellner Frontmatter More Information MY OPPOSITION The Diary of Friedrich Kellner – A German against the Third Reich Translated and Edited by ROBERT SCOTT KELLNER With a Foreword by Alan E. -
U.S. Markets for Vaccines
U.S. Markets for Vaccines U.S. Markets for Vaccines Characteristics, Case Studies, and Controversies Ernst R. Berndt, Rena N. Denoncourt, and Anjli C. Warner The AEI Press Publisher for the American Enterprise Institute WASHINGTON, D.C. Distributed to the Trade by National Book Network, 15200 NBN Way, Blue Ridge Summit, PA 17214. To order call toll free 1-800-462-6420 or 1-717-794-3800. For all other inquiries please contact the AEI Press, 1150 Seventeenth Street, N.W., Washington, D.C. 20036 or call 1-800-862-5801. Library of Congress Cataloging-in-Publication Data Berndt, Ernst R. U.S. markets for vaccines : characteristics, case studies, and controversies / Ernst R. Berndt, Rena N. Denoncourt, and Anjli C. Warner. p. ; cm. Includes bibliographical references and index. ISBN-13: 978-0-8447-4280-9 ISBN-10: 0-8447-4280-5 1. Vaccines industry—United States. 2. Market surveys—United States. I. Denoncourt, Rena N. II. Warner, Anjli C. III. Title. [DNLM: 1. Vaccines—economics—United States. 2. Drug Discovery—economics—United States. 3. Drug Industry—economics—United States. QW 805 B524u 2009] HD9675.V333.U6 2009 381'.456153720973—dc22 2009006713 13 12 11 10 09 1 2 3 4 5 6 7 © 2009 by the American Enterprise Institute for Public Policy Research, Wash- ington, D.C. All rights reserved. No part of this publication may be used or repro- duced in any manner whatsoever without permission in writing from the American Enterprise Institute except in the case of brief quotations embodied in news articles, critical articles, or reviews. The views expressed in the publications of the American Enterprise Institute are those of the authors and do not neces- sarily reflect the views of the staff, advisory panels, officers, or trustees of AEI. -
Federal Register/Vol. 84, No. 59/Wednesday, March 27, 2019
Federal Register / Vol. 84, No. 59 / Wednesday, March 27, 2019 / Proposed Rules 11473 coating removal to professional users in Environmental Defense Fund. EPA–HQ– effects on children pursuant to the UK, given the requirements for OPPT–2016–0231–0912. Executive Order 13045, entitled limited access that are in place there? 6. Public Comment. DoD Comments on MeCl ‘‘Protection of Children from and NMP 19 Jan 17 Notice of Proposed Environmental Health Risks and Safety IV. Request for Comment and Rulemaking Methylene Chloride and N- Risks’’ (62 FR 19885, April 23, 1997); or Additional Information Methylpyrrolidone; Rulemaking under TSCA Section 6(a). EPA–HQ–OPPT– to consider human health or EPA is seeking comment on all 2016–0231–0519. environmental effects on minority or information outlined in this ANPRM 7. Halogenated Solvents Industry Alliance. low-income populations pursuant to and any other information, which may Responsibly Regulating Methylene Executive Order 12898, entitled not be included in this notice, but Chloride in Paint Removal Products: an ‘‘Federal Actions to Address which you believe is important for EPA Alternative Approach to Flawed Environmental Justice in Minority to consider. Proposal Published by EPA on January Populations and Low-Income EPA specifically invites public 19, 2017. Populations’’ (59 FR 7629, February 16, comment and any additional 8. EPA. How to Get Certified as a Pesticide 1994). Applicator. https://www.epa.gov/ information in response to the questions The Agency will consider such and issues identified in Unit III. pesticide-worker-safety/how-get- certified-pesticide-applicator. Accessed comments during the development of Instructions for providing written December 18, 2018. -
The MMR Vaccine and Autism
HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Annu Rev Manuscript Author Virol. Author Manuscript Author manuscript; available in PMC 2020 September 29. Published in final edited form as: Annu Rev Virol. 2019 September 29; 6(1): 585–600. doi:10.1146/annurev-virology-092818-015515. The MMR Vaccine and Autism Frank DeStefano, Tom T. Shimabukuro Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA; Abstract Autism is a developmental disability that can cause significant social, communication, and behavioral challenges. A report published in 1998, but subsequently retracted by the journal, suggested that measles, mumps, and rubella (MMR) vaccine causes autism. However, autism is a neurodevelopmental condition that has a strong genetic component with genesis before one year of age, when MMR vaccine is typically administered. Several epidemiologic studies have not found an association between MMR vaccination and autism, including a study that found that MMR vaccine was not associated with an increased risk of autism even among high-risk children whose older siblings had autism. Despite strong evidence of its safety, some parents are still hesitant to accept MMR vaccination of their children. Decreasing acceptance of MMR vaccination has led to outbreaks or resurgence of measles. Health-care providers have a vital role in maintaining confidence in vaccination and preventing suffering, disability, and death from measles and other vaccine-preventable diseases. Keywords measles; mumps; rubella vaccine; MMR vaccine; autism; autism spectrum disorder; ADS; vaccination; immunization; vaccine safety 1. INTRODUCTION AND BACKGROUND The most damaging vaccine safety controversy of recent years began as an exploration of the possible role of measles and measles vaccines in the pathogenesis of inflammatory bowel disease (IBD). -
Alan E. Steinweis
July 2020 Alan E. Steinweis Department of History [email protected] University of Vermont Wheeler House 133 South Prospect Street Burlington, Vermont 05405 EDUCATION Ph.D., History, University of North Carolina at Chapel Hill, 1988 M.A., History, University of North Carolina at Chapel Hill, 1982 B.A., History, State University of New York at Binghamton, 1979 ACADEMIC POSITIONS Since 2009: Professor of History, University of Vermont Since 2019: Raul Hilberg Distinguished Professor of Holocaust Studies, UVM 2012-2019: Leonard and Carolyn Miller Distinguished Professor of Holocaust Studies, UVM 1993-2008: Assistant to Full Professor, History and Judaic Studies, University of Nebraska- Lincoln. Holder of the Hyman Rosenberg Professorship of History and Judaic Studies 1989-1993: Assistant Professor, Department of History, Florida State University 1988-1989: Post-Doctoral Fellow, Free University of Berlin 1986-1987: Instructor, Department of History, University of North Carolina at Chapel Hill NON-ACADEMIC EMPLOYMENT 1979-1980: National Archives of the United States, Records Declassification Reviewer AWARDS, FELLOWSHIPS, GRANTS, VISITING POSITIONS 2020: Distinguished Achievement Award, Holocaust Education Found. of Northwestern Univ 2018: Ina Levine Senior Invitational Scholar, US Holocaust Memorial Museum (Fall semester) 2013-15: Lehrstuhl für jüdische Geschichte und Kultur (Chair for Jewish History and Culture), University of Munich (October 2013-January 2015) 2011: Gastprofessur zur Erforschung des Holocaust und der deutsch-jüdischen Geschichte (Guest Professor for Research on the Holocaust and German-Jewish History), Fritz Bauer Institute, University of Frankfurt (April-August) 2003: Fulbright Professor, University of Heidelberg (March-July) 2 2002: Visiting Professor, University of Hannover, Germany (May-June) 2002: German Academic Exchange Service (DAAD), short-term grant (July-August) 2001: German Historical Institute grant for the conference “Coming to Terms with the Past in Germany: The 1960’s,” held at Univ. -
John R. Kellam
GO TO MASTER INDEX OF WARFARE WHAT IF THEY GAVE A WAR AND NOBODY CAME? FRIEND JOHN R. KELLAM, WORLD WAR II PRISONER OF CONSCIENCE UPDATE, MAY 2012: Despite the fact that he has never smoked, John now has Stage 4 lung cancer and, given the fact that he has reached the advanced age of 94½, has evidently decided that it would be better not to attempt dramatic chemotherapy or radiation treatment. He is at home surrounded by friends and family and is alert, cogent, and somewhat sardonic. Stay tuned. HDT WHAT? INDEX JOHN R. KELLAM PRISONER OF CONSCIENCE GO TO MASTER INDEX OF WARFARE The direct quotations of John R. Kellam herein originated in an interview with Caroline Besse Webster of Canaan CT, a member of the South Berkshire Monthly Meeting of the Religious Society of Friends (Quakers), in Massachusetts during the year 2001. Other historical material are from the “Stack of the Artist of Kouroo” project of Austin Meredith, considered by him to be relevant to the interviewee’s life history, philosophy, and spirituality, resulting in his determination to remain a nonparticipant in any kind of warfare whatever. John says: “I’m far enough along in age so that it is my hope that my experiences might be widely shared. It is important to me whether a generation or two of young men —and women?— can be helped to realize that there are various alternatives to letting ourselves be conscripted into warfare and a lifetime of devastating memories and guilt. Perhaps I can still be a contributor to the educational process.” HDT WHAT? INDEX JOHN R. -
Vaccine Safety in the United States: Overview and Considerations for COVID-19 Vaccines
Vaccine Safety in the United States: Overview and Considerations for COVID-19 Vaccines Updated January 29, 2021 Congressional Research Service https://crsreports.congress.gov R46593 SUMMARY R46593 Vaccine Safety in the United States: Overview January 29, 2021 and Considerations for COVID-19 Vaccines Kavya Sekar Widespread immunization efforts have been linked to increased life expectancy and Analyst in Health Policy reduced illness. U.S. vaccination programs, headed by the Centers for Disease Control and Prevention (CDC) within the Department of Health and Human Services (HHS), Agata Bodie have helped eradicate smallpox and nearly eradicate polio globally, and eliminate Analyst in Health Policy several infectious diseases domestically. With the Coronavirus Disease 2019 (COVID- 19) pandemic now causing major health and economic impacts across the world, efforts have been underway to make safe and effective vaccines available quickly to help curb spread of the virus. As of the date of this report, there are two COVID-19 vaccines authorized for emergency use by the U.S. Food and Drug Administration (FDA) and recommended by the CDC. Additional vaccines may receive authorization within months. Background Federal regulation of vaccine safety began with the Biologics Control Act of 1902, which was the first federal law to require premarket review of pharmaceutical products. Since the 1902 law was enacted, federal vaccine safety activities have expanded, with the aim of minimizing the possibility of adverse events following vaccination and detecting new adverse events as quickly as possible. Today, as covered in this report, federal efforts to ensure vaccine safety include the following activities: Premarket requirements: Clinical trials, or testing of investigational vaccines in human subjects, and U.S. -
Popular Challenges to Scientific Authority in the Vaccine Controversies of the 21St Century" (2012)
Providence College DigitalCommons@Providence Annual Undergraduate Conference on Health Third Annual Undergraduate Conference on and Society Health and Society Mar 31st, 2:30 PM - 4:00 PM Sick With Fear: Popular Challenges to Scientific uthorityA in the Vaccine Controversies of the 21st Century Ellen Watkins University of California - Los Angeles Follow this and additional works at: https://digitalcommons.providence.edu/auchs Part of the Allergy and Immunology Commons, Broadcast and Video Studies Commons, Communication Technology and New Media Commons, Community Health and Preventive Medicine Commons, Health Communication Commons, Influenza Virus accinesV Commons, Medical Immunology Commons, Preventive Medicine Commons, and the Theory, Knowledge and Science Commons Watkins, Ellen, "Sick With Fear: Popular Challenges to Scientific Authority in the Vaccine Controversies of the 21st Century" (2012). Annual Undergraduate Conference on Health and Society. 2. https://digitalcommons.providence.edu/auchs/2012/panelc1/2 This Event is brought to you for free and open access by the Conferences & Events at DigitalCommons@Providence. It has been accepted for inclusion in Annual Undergraduate Conference on Health and Society by an authorized administrator of DigitalCommons@Providence. For more information, please contact [email protected]. 1 Sick With Fear Popular Challenges to Scientific Authority in the Vaccine Controversies of the 21st Century By Ellen Watkins Abstract In the 20th century, vaccines were heralded as one of the greatest medical inventions in history. In the late 1990’s, however, the myth of vaccine-caused autism caught fire. Despite mountains of evidence disproving the link, panicking Americans eschewed vaccines and turned against their physicians. Why did Americans turn their backs on doctors, scientists, and the health industry? This paper follows the vaccine controversy of the last thirty years, looking in particular at the relationship between science and the media.