PTK7 Expression in Triple-Negative Breast Cancer
ANTICANCER RESEARCH 33: 3759-3764 (2013) PTK7 Expression in Triple-negative Breast Cancer BEYHAN ATASEVEN1,2, REGINA ANGERER1, RONALD KATES3, ANGELA GUNESCH1, PJOTR KNYAZEV4, BERNHARD HÖGEL5, CLEMENS BECKER5, WOLFGANG EIERMANN6 and NADIA HARBECK7 1Department of Gynecology and Obstetrics, Red Cross Women’s Hospital, Munich, Germany; 2Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany; 3Breast Center, Department of Gynecology and Obstetrics Maistrasse Campus, Ludwig Maximilian University Munich, Munich, Germany; 4Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany; 5Department of Pathology, Red Cross Women’s Hospital Munich, Munich, Germany; 6Department of Gynecology and Oncology, Interdiscipilnary Oncology Center Munich, Germany; 7Breast Center, Department of Gynecology and Obstetrics, Großhadern Campus, Ludwig Maximilian University Munich, Munich, Germany Abstract. Background: Protein tyrosine kinase-7 (PTK7) immunoglobulin-like loops, a transmenbrane domain and an plays an important role in cancer. Our aim was to evaluate inactive catalytic tyrosine kinase domain (2, 3). PTK7 seems PTK7 in triple-negative breast cancer (TNBC). Materials to be highly involved in the WNT (named after the Drosophilia and Methods: PTK7 Expression was assessed by Wingless (Wg) and the mouse Int-1 genes)-pathways (4), which immunohistochemistry (IHC) in 133 patients with TNBC. again represent key pathways for epithelial mesenchymal Expression levels were correlated with clinicopathological transition (EMT) and play important roles in cancer (5-8). A features and survival, taking chemotherapy into account. potential impact of PTK7 expression has been studied in Results: Positive PTK7 expression was detected in 28.6% of several malignancies, including colon, lung, gastric and breast tumors. In the total population, no significant difference was cancer, acute myeloid leukemia and liposarcoma (9-15).
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