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Biosensors Based on Odorant Binding Proteins ������������������������������������ 171 Krishna C Bioelectronic Nose Tai Hyun Park Editor Bioelectronic Nose Integration of Biotechnology and Nanotechnology 1 3 Editor Tai Hyun Park School of Chemical and Biological Engineering, Seoul National University Seoul Korea, Republic of (South Korea) ISBN 978-94-017-8612-6 ISBN 978-94-017-8613-3 (eBook) DOI 10.1007/978-94-017-8613-3 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2014937462 © Springer Science+Business Media Dordrecht 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Preface We have five senses: vision, hearing, touch, smell, and taste. Although some other senses including balance, pain, itch, and temperature senses have been reported, the five senses remain major classical senses. Among these five senses, three of them: vision, hearing, and touch, recognize physical stimuli, and the other two senses recognize chemical stimuli. The science and technology concerned with vision and hearing have been advanced enormously, while the understanding of the chemical senses, especially the sense of smell, has been very limited. The stimulus energy for the sense of vision and hearing is light and sound, re- spectively. The camera, video camera, and recorder create recorded signals which can be even delivered to remote places. Using this technology we can watch the Olympic game on TV at home. The sense of touch has been also integrated with information technology in the form of the tablet PC. On the contrary, there is no such a device which can capture smell or taste. The sense of smell is even more complicate and mysterious than the sense of taste. Electronic noses have been intended to mimic the signal processing of the sense of smell; however, elemental receptor materials of the conventional electronic noses are totally different from human olfactory receptors. If we consider that the sense of smell is a chemical sense, the same receptor materials as those in the human nose should be employed to accurately realize the human sense of smell. In the last two decades, much has been learned about the smell sensing mecha- nism in biological systems. With knowledge about the biological olfactory system and the techniques for the expression of biological receptor proteins, we are able to utilize biological materials and systems to mimic the biological olfactory system. In addition to the advances in biological and biotechnological area, nanotechnology has progressed to a great degree. The “bioelectronic nose”, the device which has a similar function to the human smell sensing system, can be realized by combining the olfactory cells or receptors with nanotechnology. The bioelectronic nose is a good example of the integration of biotechnology and nanotechnology. This book combines contributions from basic biological sciences of the olfactory system, biotechnology for the production of olfactory biological elements, and nanotechnology for the development of various sensing devices. The purpose of this book is to provide the reader with a concept, basic sciences, funda- mental technologies, applications, and perspectives of the bioelectronics nose. v vi Preface The editor is very grateful to all the contributing authors, who are leading experts in their research areas. Especially valuable suggestions from Hiroaki Matsunami and Edith Pajot-Augy are much appreciated. Proofreading assistance for the consis- tent format of this book was kindly provided by Hyun Seok Song, Jong Hyun Lim, and Hwi Jin Ko. The editor thanks Peter Butler and Sophie Lim at Springer for their advice and assistance in the publication process. School of Chemical and Biological Engineering Tai Hyun Park Advanced Institutes of Convergence Technology Seoul National University Seoul 151-742 Republic of Korea Contents 1 Concept of Bioelectronic Nose ................................................................. 1 Jong Hyun Lim and Tai Hyun Park 2 Mechanisms of Olfaction �������������������������������������������������������������������������� 23 Ruchira Sharma and Hiroaki Matsunami 3 Olfactory Receptor Proteins .................................................................... 47 Guenhaël Sanz, Jean-François Gibrat and Edith Pajot-Augy 4 Odorant-Receptor Interaction ����������������������������������������������������������������� 69 Xubo Su, Hiroaki Matsunami and Hanyi Zhuang 5 Cell-Based System for Identification of Olfactory Receptors ............... 83 Peter Yi Dong, Naihua Natalie Gong and Hiroaki Matsunami 6 Neurobiology and Cultivation of Olfactory Receptor Neurons on a Chip .................................................................................... 97 Cheil Moon, Samhwan Kim, Jisub Bae and Gabriele V. Ronnett 7 Production of Olfactory Receptors Using Commercial E. coli Cell-free Systems ��������������������������������������������������������������������������������������� 115 Karolina Corin, Xiaoqiang Wang and Shuguang Zhang 8 Production of Olfactory Receptors and Nanosomes Using Yeast System for Bioelectronic Nose ........................................................ 127 Marie-Annick Persuy, Guenhaël Sanz, Aurélie Dewaele, Christine Baly and Edith Pajot-Augy 9 Production of Olfactory Receptors and Nanovesicles Using Heterologous Cell Systems for Bioelectronic Nose ................................. 145 Hyun Seok Song and Tai Hyun Park vii viii Contents 10 Biosensors Based on Odorant Binding Proteins .................................... 171 Krishna C. Persaud and Elena Tuccori 11 Optical Methods in Studies of Olfactory System ................................... 191 Sang Hun Lee, Seung-min Park and Luke P. Lee 12 Carbon Nanotube-Based Sensor Platform for Bioelectronic Nose ....... 221 Juhun Park, Hye Jun Jin, Hyungwoo Lee, Shashank Shekhar, Daesan Kim and Seunghun Hong 13 Conducting Polymer Nanomaterial-Based Sensor Platform for Bioelectronic Nose ............................................................................... 243 Oh Seok Kwon and Jyongsik Jang 14 Applications and Perspectives of Bioelectronic Nose ............................. 263 Hwi Jin Ko, Jong Hyun Lim, Eun Hae Oh and Tai Hyun Park Index ................................................................................................................. 285 Contributors Jisub Bae Department of Brain Science, Graduate School, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea Christine Baly INRA, UR1197 NeuroBiologie de l’Olfaction, Jouy-en-Josas, France Karolina Corin Center for Bits and Atoms, Massachusetts Institute of Technology, Cambridge, MA, USA Aurélie Dewaele INRA, UR1197 NeuroBiologie de l’Olfaction, Jouy-en-Josas, France Peter Yi Dong Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA Jean-François Gibrat INRA, UR1077 Mathématique Informatique et Génome, Jouy-en-Josas, France Naihua Natalie Gong Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA Seunghun Hong Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea Jyongsik Jang School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea Hye Jun Jin Department of Physics and Astronomy, and Institute of Applied Physics, Seoul National University, Seoul, Republic of Korea Daesan Kim Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea Samhwan Kim Department of Brain Science, Graduate School, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea ix x Contributors Hwi Jin Ko Bio-MAX Institute, Seoul National University, Seoul, Republic of Korea Oh Seok Kwon School
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