A Review of the Science and Technology of Odor Measurement
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Dense Representation of Natural Odorants in the Mouse Olfactory Bulb
BRIEF COMMUNICATIONS Dense representation of Online Methods), leading to a reduced number of activated glomeruli (n = 6 odorant-mouse pairs, paired t test, P < 0.005; Fig. 1e). natural odorants in the mouse We then applied 40 different natural odorants using the olfactom- eter to minimize the animal’s stress and to have a better temporal olfactory bulb control of the odorant application. In all of the mice that we tested (n = 8), every odorant evoked a specific dense pattern of glomerular Roberto Vincis1,2, Olivier Gschwend1–3, Khaleel Bhaukaurally1–3, activity (Fig. 2a and Supplementary Fig. 1). For each odorant, we Jonathan Beroud1,2 & Alan Carleton1,2 analyzed the image sequence (Online Methods and Supplementary Fig. 2) and quantified the number of activated glomeruli (Fig. 2b In mammals, odorant molecules are thought to activate and Supplementary Fig. 3). We found that the number of activated only a few glomeruli, leading to the hypothesis that odor glomeruli for each stimulus ranged between 10 and 40 glomeruli representation in the olfactory bulb is sparse. However, the (Fig. 2b). For the same set of 30 natural stimuli, the total number of studies supporting this model used anesthetized animals or activated glomeruli per olfactory bulb was 443 ± 15 glomeruli (n = 5 monomolecular odorants at limited concentration ranges. mice; Fig. 2c,d). By merging the glomeruli activated by several odor- Using optical imaging and two-photon microscopy, we found ants (Online Methods), we obtained a map composed of glomeruli that natural odorants at their native concentrations could elicit with a unique identity showing that the natural odorants that we dense representations in the olfactory bulb. -
Taste and Smell Disorders in Clinical Neurology
TASTE AND SMELL DISORDERS IN CLINICAL NEUROLOGY OUTLINE A. Anatomy and Physiology of the Taste and Smell System B. Quantifying Chemosensory Disturbances C. Common Neurological and Medical Disorders causing Primary Smell Impairment with Secondary Loss of Food Flavors a. Post Traumatic Anosmia b. Medications (prescribed & over the counter) c. Alcohol Abuse d. Neurodegenerative Disorders e. Multiple Sclerosis f. Migraine g. Chronic Medical Disorders (liver and kidney disease, thyroid deficiency, Diabetes). D. Common Neurological and Medical Disorders Causing a Primary Taste disorder with usually Normal Olfactory Function. a. Medications (prescribed and over the counter), b. Toxins (smoking and Radiation Treatments) c. Chronic medical Disorders ( Liver and Kidney Disease, Hypothyroidism, GERD, Diabetes,) d. Neurological Disorders( Bell’s Palsy, Stroke, MS,) e. Intubation during an emergency or for general anesthesia. E. Abnormal Smells and Tastes (Dysosmia and Dysgeusia): Diagnosis and Treatment F. Morbidity of Smell and Taste Impairment. G. Treatment of Smell and Taste Impairment (Education, Counseling ,Changes in Food Preparation) H. Role of Smell Testing in the Diagnosis of Neurodegenerative Disorders 1 BACKGROUND Disorders of taste and smell play a very important role in many neurological conditions such as; head trauma, facial and trigeminal nerve impairment, and many neurodegenerative disorders such as Alzheimer’s, Parkinson Disorders, Lewy Body Disease and Frontal Temporal Dementia. Impaired smell and taste impairs quality of life such as loss of food enjoyment, weight loss or weight gain, decreased appetite and safety concerns such as inability to smell smoke, gas, spoiled food and one’s body odor. Dysosmia and Dysgeusia are very unpleasant disorders that often accompany smell and taste impairments. -
Loss of Taste and Smell After Brain Injury
Loss of taste and smell after brain injury Introduction Following a brain injury many people report that their senses of taste and/or smell have been affected. This may be as a consequence of injury to the nasal passages, damage to the nerves in the nose and mouth, or to areas of the brain itself. Loss or changes to smell and taste are particularly common after severe brain injury or stroke and, if the effects are due to damage to the brain itself, recovery is rare. The effects are also often reported after minor head injuries and recovery in these cases is more common. If recovery does occur, it is usually within a few months of the injury and recovery after more than two years is rare. Sadly, there are no treatments available for loss of taste and smell, so this factsheet is designed to provide practical suggestions on how you can compensate. It provides information on health, safety and hygiene issues, suggestions to help you to maintain a healthy, balanced diet, information on psychological effects and some other issues to consider. How are taste and smell affected by brain injury? The two senses can both be affected in a number of different ways and some definitions of the terms for the different conditions are provided below: Disorders of smell Anosmia Total loss of sense of smell Hyposmia Partial loss of sense of smell Hyperosmia Enhanced sensitivity to odours Phantosmia/Parosmia ‘False’ smells – Perceiving smells that aren’t there Dysosmia Distortion in odour perception Disorders of taste Dysgeusia Distortion or decrease in the sense of taste Ageusia Total loss of sense of taste Dysgensia Persistent abnormal taste Parageusia Perceiving a bad taste in the mouth 1 The two senses are connected and much of the sensation of taste is due to smell, so if the sense of smell is lost then the ability to detect flavour will be greatly affected. -
Review Article Olfactory Reference Syndrome
British Journal of Pharmaceutical and Medical Research Vol.04, Issue 01, Pg.1617-1625, January-February 2019 Available Online at http://www.bjpmr.org BRITISH JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH Review ISSN:2456-9836 ICV: 60.37 Article Murat Eren Özen, Murat Aydin Olfactory Reference Syndrome: A Separate Disorder Or Part Of A Spectrum 1Psychiatrist, Department of Psychiatry, Private Adana Hospital, Adana Büyük şehir Belediyesi kar şısı, No:23, Seyhan-Adana- Türkiye. 2Private Dental Clinics, Gazipa şa bulv. Emre apt n:6 (kitapsan kar şısı) k:2 d:5 Adana- Türkiye. http://drmurataydin.com ARTICLE INFO ABSTRACT This article provides a narrative review of the literature on olfactory reference syndrome Article History: Received on (ORS) to address issues focusing on its clinical features. Similarities and/or differences with other psychiatric disorders such as obsessive-compulsive spectrum disorders, social anxiety 10 th Jan, 2019 Peer Reviewed disorder (including a cultural syndrome; taijin kyofusho), somatoform disorders and hypochondriasis, delusional disorder are discussed. ORS is related to a symptom of taijin on 24 th Jan, 2019 Revised kyofusho (e.g. jikoshu-kyofu variant of taijin kyofusho) Although recognition of this syndromes more than a century provide consistent descriptions of its clinical features, the on 17 th Feb, 2019 Published limited data on this topic make it difficult to form a specific diagnostic criteria. The core on 24 th Feb, symptom of the patients with ORS is preoccupation with the belief that one emits a foul or 2019 offensive body odor, which is not perceived by others. Studies on ORS reveal some limitations. -
Let's Talk About . . . Migraine and Dizziness
LET’S TALK ABOUT . MIGRAINE AND DIZZINESS Migraine is almost as common as high blood Key points pressure in the Canadian population. It is more • A migraine is a severe headache. common than asthma or diabetes. An estimated 300,000 Canadians suffer needlessly because they • Of over 300 types of migraine, dizziness is have either been misdiagnosed or not diagnosed a symptom of two: migraine with brainstem with chronic migraine. aura and vestibular migraine. • See a doctor who specialized in headaches for accurate diagnosis. What are the symptoms of migraine with dizziness? • Lifestyle changes may help prevent or lessen the occurrence of migraine. Common symptoms include: • Medication may help prevent migraine. • Visual aura – you may see flashes of light or have blind spots in your vision. • Localized pain behind or near the eye on one Note: Concussion also causes migraine-type side of your head. dizziness – concussion sufferers can substitute the • Light, sound (hyperacusis) and odor sensitivity word “concussion” for “migraine” in the information (hyperosmia). You may have some sensitivity below. daily and increased sensitivity when you have migraine. • Visual vestibular mismatch (the brain’s What is migraine? hypersensitivity to motion) is common in Migraine is a neurovascular headache, meaning it migraine-type brains both episodically and can be triggered by annoyance or disturbance to chronically. Sometimes it will occur without the nerves or blood vessels in the brain. All headache and you may feel “off” for an hour or migraines are caused by the same type of two. neurotransmitter dysregulation and respond to the • Vertigo (spinning sensation) – it may start same treatments. -
Single Olfactory Receptors Set Odor Detection Thresholds
City University of New York (CUNY) CUNY Academic Works Publications and Research Hunter College 2018 Single olfactory receptors set odor detection thresholds Adam Dewan Northwestern University Annika Cichy Northwestern University Jingji Zhang Northwestern University Kayla Miguel Northwestern University Paul Feinstein CUNY Hunter College See next page for additional authors How does access to this work benefit ou?y Let us know! More information about this work at: https://academicworks.cuny.edu/hc_pubs/550 Discover additional works at: https://academicworks.cuny.edu This work is made publicly available by the City University of New York (CUNY). Contact: [email protected] Authors Adam Dewan, Annika Cichy, Jingji Zhang, Kayla Miguel, Paul Feinstein, Dmitry Rinberg, and Thomas Bozza This article is available at CUNY Academic Works: https://academicworks.cuny.edu/hc_pubs/550 ARTICLE DOI: 10.1038/s41467-018-05129-0 OPEN Single olfactory receptors set odor detection thresholds Adam Dewan1, Annika Cichy1, Jingji Zhang1, Kayla Miguel1, Paul Feinstein2, Dmitry Rinberg3 & Thomas Bozza 1 In many species, survival depends on olfaction, yet the mechanisms that underlie olfactory sensitivity are not well understood. Here we examine how a conserved subset of olfactory receptors, the trace amine-associated receptors (TAARs), determine odor detection fi 1234567890():,; thresholds of mice to amines. We nd that deleting all TAARs, or even single TAARs, results in significant odor detection deficits. This finding is not limited to TAARs, as the deletion of a canonical odorant receptor reduced behavioral sensitivity to its preferred ligand. Remarkably, behavioral threshold is set solely by the most sensitive receptor, with no contribution from other highly sensitive receptors. -
Respiration, Neural Oscillations, and the Free Energy Principle
fnins-15-647579 June 23, 2021 Time: 17:40 # 1 REVIEW published: 29 June 2021 doi: 10.3389/fnins.2021.647579 Keeping the Breath in Mind: Respiration, Neural Oscillations, and the Free Energy Principle Asena Boyadzhieva1*† and Ezgi Kayhan2,3† 1 Department of Philosophy, University of Vienna, Vienna, Austria, 2 Department of Developmental Psychology, University of Potsdam, Potsdam, Germany, 3 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany Scientific interest in the brain and body interactions has been surging in recent years. One fundamental yet underexplored aspect of brain and body interactions is the link between the respiratory and the nervous systems. In this article, we give an overview of the emerging literature on how respiration modulates neural, cognitive and emotional processes. Moreover, we present a perspective linking respiration to the free-energy principle. We frame volitional modulation of the breath as an active inference mechanism Edited by: in which sensory evidence is recontextualized to alter interoceptive models. We further Yoko Nagai, propose that respiration-entrained gamma oscillations may reflect the propagation of Brighton and Sussex Medical School, United Kingdom prediction errors from the sensory level up to cortical regions in order to alter higher level Reviewed by: predictions. Accordingly, controlled breathing emerges as an easily accessible tool for Rishi R. Dhingra, emotional, cognitive, and physiological regulation. University of Melbourne, Australia Georgios D. Mitsis, Keywords: interoception, respiration-entrained neural oscillations, controlled breathing, free-energy principle, McGill University, Canada self-regulation *Correspondence: Asena Boyadzhieva [email protected] INTRODUCTION † These authors have contributed “The “I think” which Kant said must be able to accompany all my objects, is the “I breathe” which equally to this work actually does accompany them. -
Olfactory Dysfunction
Olfactory Dysfunction: By Steven Sobol, MD, MSc; Saul Frenkiel, MD, FRCSC; and Debbie Mouadeb he sense of smell plays an important role in protecting Tman from environmental dangers, such as fire, natural gas leaks and spoiled food. Physiologically, the chemical senses aid in normal digestion by triggering gastrointestinal secretions.1 Smell influences the palatability of food. Defects in the sense of smell are associated with alterations in perceptions of flavor, leading to anorexia and weight loss. Psychologically, smell is powerful in establishing strong positive and negative memories, and affects socialization and interpersonal relationships. Smell dysfunctions often mean considerable disability and a lower quality of life. Loss or decreased olfactory function affects approximately one per cent of Americans under the age of 60 and more than half the population over that age.2 Aside from having a substantial impact on an individual’s quality of life, olfactory dysfunction may signal an underlying disease. Smell disorders have been largely overlooked by the medical community because of a lack of knowledge and understanding of the sense of smell and its disease states, as well its diagnosis and management. Patients with olfactory disorders need to be clinically assessed, and the etiology and anatomical location of their disorder should be sought out. The Canadian Journal of Diagnosis / August 2002 55 Olfactory Dysfunction Summary What are the causes of olfactory dysfunction? 1.Conductive olfactory loss is any process that causes sufficient obstruction in the nose preventing odorant molecules from reaching the olfactory epithelium. 2.Sensorineural olfactory loss is any process that directly affects and impairs either the olfactory epithelium or the central olfactory pathways. -
Olfactory Dysfunction in COVID-19 Diagnosis and Management
Clinical Review & Education JAMA Insights | CLINICAL UPDATE Olfactory Dysfunction in COVID-19 Diagnosis and Management Katherine Lisa Whitcroft, BSc, MBChB; Thomas Hummel, MD As of May 1, 2020, more than 3 000 000 people worldwide have olfactory neuroepithelium may result in inflammatory changes been infected with the novel coronavirus, severe acute respiratory that impair olfactory receptor neuron function, cause subsequent syndrome coronavirus 2 (SARS-CoV-2). The CDC has highlighted key olfactory receptor neuron damage, and/or impair subsequent symptoms that may suggest coronavirus disease 2019 (COVID-19), neurogenesis. Such changes may cause temporary or longer- including cough, shortness of breath or difficulty breathing, fever, lasting OD. Previous work in transgenic animal models showed chills, muscle pain, sore throat, and new loss of smell or taste.1 intracranial entry of SARS-CoV via the olfactory bulb.8 This has led The inclusion of loss of smell or taste among these symptoms to speculation that SARS-CoV-2 may penetrate intracranially with follows the emergence of evidence that suggests that COVID-19 fre- possible downstream effects on olfactory and nonolfactory brain quently impairs the sense of smell. For example, in a study from Iran, regions, which may adversely affect olfactory function. 59 of 60 patients hospitalized with COVID-19 were found to have an impaired sense of smell according to psychophysical olfactory Clinical Assessment testing.2 Olfactory dysfunction (OD), defined as the reduced or dis- During the current pandemic, patients with recent-onset acute torted ability to smell during sniffing (orthonasal olfaction) or eat- smell and/or taste dysfunction, with or without other symptoms of ing (retronasal olfaction), is often reported in mild or even asymp- COVID-19, should undergo a period of self-isolation and, when pos- tomatic cases; in a study from Italy,64% of 202 mildly symptomatic sible, SARS-CoV-2 testing. -
Prof. Dr. Med. Th. Zahnert Die Olfaktorische Wahrnehmung Von Bour
Aus der Klinik für Hals-, Nasen und Ohrenheilkunde Direktor: Prof. Dr. med. Th. Zahnert Die olfaktorische Wahrnehmung von Bourgeonal durch infertile und fertile Männer und Genotypisierung des Bourgeonalrezeptors hOR 17-4 Dissertationsschrift zur Erlangung eines doctor medicinae (Dr. med.) der Medizinischen Fakultät Carl Gustav Carus der Technischen Universität Dresden vorgelegt von Eva Kemper aus Würselen Berlin 2014 1. Gutachter: 2. Gutachter: Tag der mündlichen Prüfung: gez: ------------------------------------------------- Vorsitzender der Promotionskommission I Inhaltsverzeichnis 1. Einleitung................................................................................................................................. 1 1.1. Hintergrund ...................................................................................................................... 1 1.2. Problemstellung ............................................................................................................... 2 1.3. Grundlagen ...................................................................................................................... 2 1.3.1. Der Geruchssinn ........................................................................................................ 2 1.3.2. Das menschliche Riechrezeptorrepertoire ............................................................... 4 1.3.3. Ektopische Expression olfaktorischer Rezeptoren und Spermien-chemotaxis ....... 5 1.3.4. Der olfaktorische Rezeptor hOR 17-4 ...................................................................... -
Phantosmia and Migraine with and Without Headache
ISSN 0017-8748 Headache doi: 10.1111/head.12890 VC 2016 American Headache Society Published by Wiley Periodicals, Inc. Expert Opinions Phantosmia and Migraine With and Without Headache Yasmin I. Jion, MD; Brian M. Grosberg, MD; Randolph W. Evans, MD Phantosmia is a rare migraine aura. We present two cases of phantosmias occurring before migraine headaches and also without headaches. To our knowledge, these are the third and fourth cases of phantosmias ever reported due to migraine aura without headache. Key words: phantosmia, olfactory hallucination, migraine, headache (Headache 2016;00:00-00) CASE HISTORIES take acetaminophen with relief in 1–2 hours. Stress Case 1.—This is a 53-year-old female with a 9- was a trigger. month history of smelling a dirty dog smell as often as She saw a cardiologist about 1 month after 2–3 times a day or up to 4 days without the smell with onset and had a CT of the brain without contrast an average duration of 5 minutes (range 30 seconds to on 1/19/15 that was normal. She saw two ENT phy- 1 hour) followed by a headache about every 2 weeks sicians who found normal exams. but most of the time without an associated headache. Past medical history of hyperlipidemia on prav- She described a bifrontal throbbing headache with an astatin. Family history: sister has migraine. Neuro- intensity of 6/10 associated with nausea, light and noise logical examination was normal. sensitivity but no vomiting. She always takes ibuprofen MRI of the brain with and without contrast was with relief in 1 hour. -
A Connective Tissue Disorder May Underlie ESSENCE Problems In
G Model RIDD-2963; No. of Pages 11 ARTICLE IN PRESS Research in Developmental Disabilities xxx (2016) xxx–xxx Contents lists available at ScienceDirect Research in Developmental Disabilities Review article A connective tissue disorder may underlie ESSENCE problems in childhood a,∗ b c,d Carolina Baeza-Velasco , Rodney Grahame , Jaime F. Bravo a Department of Psychology, Laboratory of Psychopathology and Health Process, University Paris Descartes – Sorbonne Paris Cité, Boulogne-Billancourt, France b Division of Medicine, University College London, London, UK c Medical School, University of Chile, Santiago, Chile d Rheumatology Unit, San Juan de Dios Hospital, Santiago, Chile a r t i c l e i n f o a b s t r a c t Article history: Background: Ehlers-Danlos syndrome hypermobility type, also known as Joint Hypermo- Received 19 May 2016 bility Syndrome (EDS-HT/JHS), is the most common hereditary disorder of the connective Received in revised form 24 October 2016 tissue (HDCT). It is characterized by tissue fragility, joint hypermobility and a wide range Accepted 25 October 2016 of articular and non-articular manifestations, which often appear in infancy. The clinical Available online xxx picture of EDS-HT/JHS is poorly known by the medical community, as is the presence of “ESSENCE” (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Exami- Keywords: nations) problems in affected children. ESSENCE Aim: The present work reviews the clinical and empirical evidence for ESSENCE difficulties Joint hypermobility syndrome in children with EDS-HT/JHS. Ehlers-Danlos syndrome Method: A narrative review of the literature was undertaken following a comprehensive Neurodevelopmental disorders Attention deficit search of scientific online databases and reference lists.