August 24, 2021 u vol. 118 u no. 34

From the Cover

e2026212118 Evolutionary effects of seed dormancy e2106130118 Tree fecundity and senescence e2103081118 Economics of climate tipping points e2026111118 Forest refugium and glacial–interglacial cycles e2101985118 Moonrise timing and coral spawning

Contents

THIS WEEK IN PNAS—This week’s research highlights Cover image: Pictured is the primrose eiti3421118 In This Issue ( florida), a pest of evening primroses ( biennis). Anurag A. Agrawal et al. studied the effects SCIENCE AND CULTURE—How science intersects with culture of dormancy on the evolutionary e2113327118 Wildfires pose a burning problem for wines and winemakers adaptation of the evening primrose. The Jyoti Madhusoodanan authors either exposed five generations of experimental plantings to predation or sheltered the plantings RETROSPECTIVE and allowed the seeds to remain dormant in the soil for at least 5 years e2112969118 Stephen T. Warren: Human geneticist who advanced understanding of before reviving the seeds and mutational mechanisms and developmental disorders genotyping the resulting colonizers. All David L. Nelson and C. Thomas Caskey of the resurrected evening primrose populations recovered a level of genetic diversity comparable with the start of COMMENTARIES the experiment, but insect-exposed e2110556118 Uncoupling in intrinsic brain activity populations maintained differences in Manu S. Goyal and Abraham Z. Snyder fruit chemical defense and life-history See companion article, e2021913118, in vol. 118, issue 27 traits. The results suggest that dormancy can have long-term effects on the e2112191118 Linking amorphous ice and supercooled liquid water evolutionary responses of plants to Thomas E. Gartner III environmental change. See the article See companion article, e2108194118, in vol. 118, issue 30 by Agrawal et al., e2026212118. Image credit: Anurag A. Agrawal (Cornell University, Ithaca, NY) and Kent Loeffler PERSPECTIVE (photographer). e2024358118 Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome Bindu D. Paul, Marian D. Lemle, Anthony L. Komaroff, and Solomon H. Snyder

LETTERS e2107239118 The human factor between airborne pollen concentrations and COVID- 19 disease dynamics Cornelia Betsch and Philipp Sprengholz e2110982118 Reply to Betsch and Sprengholz: Higher SARS-CoV-2 infection numbers related to more airborne pollen, regardless of testing frequency Stefanie Gilles, Claudia Traidl-Hoffmann, and Athanasios Damialis

Free online through the PNAS open access option. PNAS u August 24, 2021 u vol. 118 u no. 34 u iii–viii Downloaded by guest on September 24, 2021 APPLIED PHYSICAL SCIENCES INAUGURAL ARTICLE e2106938118 Synergistic dispersal of plant pathogen e2106130118 Is there tree senescence? The spores by jumping-droplet condensation fecundity evidence and wind Tong Qiu, Marie-Claire Aravena, Robert Andrus, Ranit Mukherjee, Hope A. Gruszewski, Landon T. Davide Ascoli, Yves Bergeron, Roberta Berretti, Michal Bilyeu, David G. Schmale III, Bogdziewicz, Thomas Boivin, Raul Bonal, Thomas and Jonathan B. Boreyko Caignard, Rafael Calama, J. Julio Camarero, Connie J. – Clark, Benoit Courbaud, Sylvain Delzon, Sergio e2105211118 Elastically driven Kelvin Helmholtz-like Donoso Calderon, William Farfan-Rios, Catherine A. instability in straight channel flow Gehring, Gregory S. Gilbert, Cathryn H. Greenberg, Narsing K. Jha and Victor Steinberg Qinfeng Guo, Janneke Hille Ris Lambers, Kazuhiko Hoshizaki, Ines Ibanez, Valentin Journe´, Christopher L. BIOPHYSICS AND COMPUTATIONAL BIOLOGY Kilner, Richard K. Kobe, Walter D. Koenig, Georges e2023381118 Noise-induced properties of active dendrites Kunstler, Jalene M. LaMontagne, Mateusz Ledwon, Carl van Vreeswijk and Farzada Farkhooi James A. Lutz, Renzo Motta, Jonathan A. Myers, Thomas A. Nagel, Chase L. Nun˜ez, Ian S. Pearse, CHEMISTRY Łukasz Piechnik, John R. Poulsen, Renata e2109408118 Electrochemical borylation of carboxylic acids Poulton-Kamakura, Miranda D. Redmond, Chantal D. Lisa M. Barton, Longrui Chen, Donna G. Blackmond, Reid, Kyle C. Rodman, C. Lane Scher, Harald Schmidt and Phil S. Baran Van Marle, Barbara Seget, Shubhi Sharma, Miles Silman, Jennifer J. Swenson, Margaret Swift, Maria e2101596118 An in vivo selection-derived D-peptide for Uriarte, Giorgio Vacchiano, Thomas T. Veblen, Amy V. engineering erythrocyte-binding antigens that Whipple, Thomas G. Whitham, Andreas P. Wion, S. promote immune tolerance Joseph Wright, Kai Zhu, Jess K. Zimmerman, _ Alexander R. Loftis, Genwei Zhang, Coralie Backlund, Magdalena Zywiec, and James S. Clark Anthony J. Quartararo, Novalia Pishesha, Cameron C. Hanna, Carly K. Schissel, Daniel Garafola, Andrei BRIEF REPORTS Loas, R. John Collier, Hidde Ploegh, Darrell J. Irvine, e2105337118 Adaptive staffing can mitigate essential and Bradley L. Pentelute worker disease and absenteeism in an e2108573118 Sustainable and feasible reagent-free electro- emerging epidemic Fenton via sequential dual- Elliot Aguilar, Nicholas J. Roberts, Ismail Uluturk, cathode electrocatalysis Patrick Kaminski, John W. Barlow, Andreas G. Zori, Jiabei Wang, Shizhen Li, Qiyue Qin, Laurent He´bert-Dufresne, and Benjamin D. Zusman and Chuang Peng e2101674118 Mitochondrial fatty acid utilization increases e2100608118 Two-dimensional electronic–vibrational sum chromatin oxidative stress in cardiomyocytes frequency spectroscopy for interactions Ivan Menendez-Montes, Salim Abdisalaam, Feng of electronic and nuclear motions Xiao, Nicholas T. Lam, Shibani Mukherjee, Luke I. at interfaces Szweda, Aroumougame Asaithamby, Gang-Hua Deng, Yuqin Qian, Tong Zhang, Jian Han, and Hesham A. Sadek Hanning Chen, and Yi Rao e2109636118 Bindin is essential for fertilization in the e2106750118 Cryo-EM structures of Escherichia coli sea urchin cytochrome bo3 reveal bound phospholipids Gary M. Wessel, Yuuko Wada, Mamiko Yajima, and ubiquinone-8 in a dynamic substrate and Masato Kiyomoto binding site e2107934118 Poor data stewardship will hinder global Jiao Li, Long Han, Francesca Vallese, Ziqiao Ding, genetic diversity surveillance Sylvia K. Choi, Sangjin Hong, Yanmei Luo, Bin Liu, Rachel H. Toczydlowski, Libby Liggins, Michelle R. Chun , Emad Tajkhorshid, Jiapeng Zhu, Oliver Gaither, Tanner J. Anderson, Randi L. Barton, Justin T. Clarke, Kai Zhang, and Robert Gennis Berg, Sofia G. Beskid, Beth Davis, Alonso Delgado, e2112021118 Atomic view of cosolute-induced protein Emily Farrell, Maryam Ghoojaei, Nan Himmelsbach, denaturation probed by NMR solvent Ann E. Holmes, Samantha R. Queeno, Thienthanh paramagnetic relaxation enhancement Trinh, Courtney A. Weyand, Gideon S. Bradburd, Yusuke Okuno, Janghyun Yoo, Charles D. Cynthia Riginos, Robert J. Toonen, Schwieters, Robert B. Best, Hoi Sung Chung, and Eric D. Crandall and G. Marius Clore

PHYSICAL SCIENCES EARTH, ATMOSPHERIC, AND PLANETARY APPLIED MATHEMATICS SCIENCES e2021840118 Control of low flow regions in the cortical e2100995118 The strength of the Earth’s magnetic vasculature determines optimal field from Pre-Pottery to Pottery arterio-venous ratios Neolithic, Jordan Yujia Qi and Marcus Roper Anita Di Chiara, Lisa Tauxe, Thomas E. Levy, Mohammad Najjar, Fabio Florindo, e2023719118 Counting equilibria of large complex systems and Erez Ben-Yosef by instability index •− e2109768118 The trisulfur radical ion S controls platinum Ge´rard Ben Arous, Yan V. Fyodorov, 3 and Boris A. Khoruzhenko transport by hydrothermal fluids Gleb S. Pokrovski, Maria A. Kokh, Elsa Desmaele, e2105826118 Cross-correlation analysis of X-ray photon Cle´ment Laskar, Elena F. Bazarkina, Anastassia Y. correlation spectroscopy to extract Borisova (А.Ю.Борисова), Denis Testemale, Jean-Louis rotational diffusion coefficients Hazemann, Rodolphe Vuilleumier, Guillaume Ferlat, Zixi Hu, Jeffrey J. Donatelli, and James A. Sethian and Antonino Marco Saitta

iv u www.pnas.org Contents Downloaded by guest on September 24, 2021 e2017342118 Intensity of the Earth’s magnetic field: e2020014118 Droplet tilings for rapid exploration of Evidence for a Mid-Paleozoic dipole low spatially constrained many-body systems Louise M. A. Hawkins, J. Michael Grappone, Anton Molina, Shailabh Kumar, Stefan Karpitschka, Courtney J. Sprain, Patipan Saengduean, Edward J. and Manu Prakash Sage, Sheikerra Thomas-Cunningham, Banusha e2106744118 Optical spectral weight, phase stiffness, and Kugabalan, and Andrew J. Biggin TC bounds for trivial and topological flat e2103081118 Economic impacts of tipping points in the band superconductors climate system Nishchhal Verma, Tamaghna Hazra, Simon Dietz, James Rising, Thomas Stoerk, and Mohit Randeria and Gernot Wagner e2100691118 Nonlocal topological insulators: Deterministic e2026111118 1.36 million years of Mediterranean forest aperiodic arrays supporting localized refugium dynamics in response to glacial– topological states protected by interglacial cycle strength nonlocal symmetries Timme Donders, Konstantinos Panagiotopoulos, Kai Chen, Matthew Weiner, Mengyao Li, Xiang Ni, Andreas Koutsodendris, Adele Bertini, Anna Maria Andrea Alu`, and Alexander B. Khanikaev Mercuri, Alessia Masi, Nathalie Combourieu-Nebout, Se´bastien Joannin, Katerina Kouli, Ilias Kousis, Odile Peyron, Paola Torri, Assunta Florenzano, Alexander SOCIAL SCIENCES Francke, Bernd Wagner, and Laura Sadori ANTHROPOLOGY ENGINEERING e2100995118 The strength of the Earth’s magnetic e2111144118 Velocity transformation for compressible field from Pre-Pottery to Pottery wall-bounded turbulent flows with Neolithic, Jordan and without heat transfer Anita Di Chiara, Lisa Tauxe, Thomas E. Levy, Kevin Patrick Griffin, Lin Fu, and Parviz Moin Mohammad Najjar, Fabio Florindo, and Erez Ben-Yosef e2105889118 Electrochemical implications of modulating the solvation shell around redox active organic e2107204118 On randomly changing conformity bias in species in aqueous organic redox cultural transmission flow batteries Kaleda K. Denton, Uri Liberman, and Marcus W. Feldman Kritika Sharma, Shrihari Sankarasubramanian, Javier Parrondo, and Vijay Ramani ECONOMIC SCIENCES e2103198118 A dynamic electrically driven soft valve for e2103081118 Economic impacts of tipping points in the control of soft hydraulic actuators climate system Siyi Xu, Yufeng Chen, Nak-Seung P. Hyun, Simon Dietz, James Rising, Thomas Stoerk, Kaitlyn P. Becker, and Robert J. Wood and Gernot Wagner ’ e2026596118 Electricity consumption of Singaporean e2105710118 On the value(s) of time: Workers value of their households reveals proactive community time depends on mode of valuation response to COVID-19 progression Gal Smitizsky, Wendy Liu, and Uri Gneezy Gururaghav Raman and Jimmy Chih-Hsien Peng PSYCHOLOGICAL AND COGNITIVE SCIENCES e2100761118 The Fermi–Dirac distribution provides a calibrated e2101743118 Parallel hippocampal-parietal circuits for self- probabilistic output for binary classifiers and goal-oriented processing Sung-Cheol Kim, Adith S. Arun, Mehmet Eren Ahsen, Robert Vogel, and Gustavo Stolovitzky Annie Zheng, David F. Montez, Scott Marek, Adrian W. Gilmore, Dillan J. Newbold, Timothy O. Laumann, Benjamin P. Kay, PHYSICS Nicole A. Seider, Andrew N. Van, Jacqueline M. e2104191118 Topological braiding and virtual particles on Hampton, Dimitrios Alexopolous, Bradley L. the cell membrane Schlaggar, Chad M. Sylvester, Deanna J. Greene, Jinghui Liu, Jan F. Totz, Pearson W. Miller, Alasdair D. Joshua S. Shimony, Steven M. Nelson, Gagan S. Hastewell, Yu-Chen Chao, Jo¨rn Dunkel, and Nikta Fakhri Wig, Caterina Gratton, Kathleen B. McDermott, e2026746118 Genealogical structure changes as Marcus E. Raichle, Evan M. Gordon, and Nico U. F. Dosenbach range expansions transition from pushed to pulled Gabriel Birzu, Oskar Hallatschek, and Kirill S. Korolev BIOLOGICAL SCIENCES e2104556118 Band gaps of crystalline solids from AGRICULTURAL SCIENCES Wannier-localization–based optimal tuning of a screened range-separated e2104315118 Global range expansion history of pepper hybrid functional (Capsicum spp.) revealed by over 10,000 Dahvyd Wing, Guy Ohad, Jonah B. Haber, Marina R. genebank accessions Filip, Stephen E. Gant, Jeffrey B. Neaton, Pasquale Tripodi, Mark Timothy Rabanus-Wallace, and Leeor Kronik Lorenzo Barchi, Sandip Kale, Salvatore Esposito, Alberto Acquadro, Roland Schafleitner, Maarten e2106881118 Vanishing nematic order beyond the van Zonneveld, Jaime Prohens, Maria Jose´ Diez, pseudogap phase in overdoped Andreas Bo¨rner, Je´re´my Salinier, Bernard cuprate superconductors Caromel, Arnaud Bovy, Filiz Boyaci, Gancho Naman K. Gupta, Christopher McMahon, Ronny Pasev, Ronny Brandt, Axel Himmelbach, Ezio Sutarto, Tianyu Shi, Rantong Gong, Haofei I. Wei, Portis, Richard Finkers, Sergio Lanteri, Ilan Paran, Kyle M. Shen, Feizhou He, Qianli Ma, Mirela Dragomir, Ve´ronique Lefebvre, Giovanni Giuliano, Bruce D. Gaulin, and David G. Hawthorn and Nils Stein

Contents PNAS u August 24, 2021 u vol. 118 u no. 34 u v Downloaded by guest on September 24, 2021 APPLIED BIOLOGICAL SCIENCES e2021742118 α-Synuclein kinetically regulates the nascent e2106938118 Synergistic dispersal of plant pathogen fusion pore dynamics spores by jumping-droplet condensation Rohith K. Nellikka, Bhavya R. Bhaskar, and wind Kinjal Sanghrajka, Swapnali S. Patil, Ranit Mukherjee, Hope A. Gruszewski, Landon T. and Debasis Das Bilyeu, David G. Schmale III, e2103674118 Folding and misfolding of potassium channel and Jonathan B. Boreyko monomers during assembly e2106612118 Engineering genetic devices for in vivo control and tetramerization of therapeutic T cell activity triggered by Kevin C. Song, Andrew V. Molina, Ruofan Chen, the dietary molecule resveratrol Isabelle A. Gagnon, Young Hoon Koh, Benoıˆt Roux, Linfeng Yang, Jianli Yin, Jiali Wu, Longliang Qiao, and Tobin R. Sosnick Evan M. Zhao, Fengfeng Cai, and Haifeng Ye CELL BIOLOGY BIOCHEMISTRY e2108145118 Wnt signaling recruits KIF2A to the spindle to e2106750118 Cryo-EM structures of Escherichia coli ensure chromosome congression and alignment during mitosis cytochrome bo3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate Anja Bufe, Ana Garcı´a del Arco, Magdalena Hennecke, binding site Anchel de Jaime-Soguero, Matthias Ostermaier, Yu- Chih Lin, Anja Ciprianidis, Janina Hattemer, Ulrike Jiao Li, Long Han, Francesca Vallese, Ziqiao Ding, Engel, Petra Beli, Holger Bastians, Sylvia K. Choi, Sangjin Hong, Yanmei Luo, Bin Liu, and Sergio P. Acebro´n Chun Kit Chan, Emad Tajkhorshid, Jiapeng Zhu, Oliver Clarke, Kai Zhang, and Robert Gennis e2110483118 Molecular basis of cholesterol efflux via ABCG DEVELOPMENTAL BIOLOGY subfamily transporters e2105272118 Regulation of metamorphosis in Yingyuan Sun, Jin Wang, Tao Long, Xiaofeng Qi, Linda neopteran is conserved Donnelly, Nadia Elghobashi-Meinhardt, Leticia in the paleopteran Cloeon Esparza, Jonathan C. Cohen, Xiao-Song Xie, Helen H. Hobbs, and Xiaochun Li dipterum (Ephemeroptera) Orathai Kamsoi, Alba Ventos-Alfonso, Fernando e2105014118 Insights into the bilayer-mediated toppling Casares, Isabel Almudi, and Xavier Belles mechanism of a folate-specific ECF transporter by cryo-EM Chancievan Thangaratnarajah, Jan Rheinberger, ECOLOGY Cristina Paulino, and Dirk J. Slotboom e2106130118 Is there tree senescence? The fecundity evidence Tong Qiu, Marie-Claire Aravena, Robert Andrus, BIOPHYSICS AND COMPUTATIONAL BIOLOGY Davide Ascoli, Yves Bergeron, Roberta Berretti, Michal e2021840118 Control of low flow regions in the cortical Bogdziewicz, Thomas Boivin, Raul Bonal, Thomas vasculature determines optimal Caignard, Rafael Calama, J. Julio Camarero, Connie J. arterio-venous ratios Clark, Benoit Courbaud, Sylvain Delzon, Sergio Yujia Qi and Marcus Roper Donoso Calderon, William Farfan-Rios, Catherine A. Gehring, Gregory S. Gilbert, Cathryn H. Greenberg, e2104191118 Topological braiding and virtual particles on Qinfeng Guo, Janneke Hille Ris Lambers, Kazuhiko the cell membrane Hoshizaki, Ines Ibanez, Valentin Journe´, Christopher L. Jinghui Liu, Jan F. Totz, Pearson W. Miller, Alasdair D. Kilner, Richard K. Kobe, Walter D. Koenig, Georges Hastewell, Yu-Chen Chao, Jo¨rn Dunkel, Kunstler, Jalene M. LaMontagne, Mateusz Ledwon, and Nikta Fakhri James A. Lutz, Renzo Motta, Jonathan A. Myers, e2112021118 Atomic view of cosolute-induced protein Thomas A. Nagel, Chase L. Nun˜ez, Ian S. Pearse, Łukasz Piechnik, John R. Poulsen, Renata denaturation probed by NMR solvent Poulton-Kamakura, Miranda D. Redmond, Chantal D. paramagnetic relaxation enhancement Reid, Kyle C. Rodman, C. Lane Scher, Harald Schmidt Yusuke Okuno, Janghyun Yoo, Charles D. Van Marle, Barbara Seget, Shubhi Sharma, Miles Schwieters, Robert B. Best, Hoi Sung Chung, Silman, Jennifer J. Swenson, Margaret Swift, Maria and G. Marius Clore Uriarte, Giorgio Vacchiano, Thomas T. Veblen, Amy V. e2103554118 Targeted in situ cross-linking mass Whipple, Thomas G. Whitham, Andreas P. Wion, S. Joseph Wright, Kai Zhu, Jess K. Zimmerman, spectrometry and integrative modeling reveal _ the architectures of three proteins from Magdalena Zywiec, and James S. Clark SARS-CoV-2 e2026111118 1.36 million years of Mediterranean forest Moriya Slavin, Joanna Zamel, Keren Zohar, refugium dynamics in response to glacial– Tsiona Eliyahu, Merav Braitbard, Esther Brielle, interglacial cycle strength Leah Baraz, Miri Stolovich-Rain, Ahuva Friedman, Timme Donders, Konstantinos Panagiotopoulos, Dana G. Wolf, Alexander Rouvinski, Michal Andreas Koutsodendris, Adele Bertini, Anna Maria Linial, Dina Schneidman-Duhovny, Mercuri, Alessia Masi, Nathalie Combourieu-Nebout, and Nir Kalisman Se´bastien Joannin, Katerina Kouli, Ilias Kousis, Odile e2026719118 Assisted assembly of bacteriophage T7 core Peyron, Paola Torri, Assunta Florenzano, Alexander components for genome translocation Francke, Bernd Wagner, and Laura Sadori across the bacterial envelope e2104942118 Metabolism drives demography in an Mar Pe´rez-Ruiz, Mar Pulido-Cid, Juan Roma´n Luque- experimental field test Ortega, Jose´ Marı´a Valpuesta, Ana Cuervo, Lukas Schuster, Hayley Cameron, Craig R. White, and Jose´ L. Carrascosa and Dustin J. Marshall

vi u www.pnas.org Contents Downloaded by guest on September 24, 2021 e2102733118 Metapopulation capacity determines food MEDICAL SCIENCES chain length in fragmented landscapes e2020227118 Parsing β-catenin’s cell adhesion and Wnt Shaopeng Wang (王少鹏), Ulrich Brose, Saskya van signaling functions in malignant mammary Nouhuys, Robert D. Holt, and Michel Loreau tumor progression David Buechel, Nami Sugiyama, Natalia Rubinstein, ENVIRONMENTAL SCIENCES Meera Saxena, Ravi K. R. Kalathur, Fabiana Lu¨o¨nd, Vida e2101985118 Moonrise timing is key for synchronized Vafaizadeh, Tomas Valenta, George Hausmann, spawning in coral Dipsastraea speciosa Claudio Cantu`, Konrad Basler, and Gerhard Christofori Che-Hung Lin, Shunichi Takahashi, Aziz J. Mulla, and Yoko Nozawa e2024055118 Acquired resistance to PRMT5 inhibition induces concomitant collateral EVOLUTION sensitivity to paclitaxel e2026746118 Genealogical structure changes as Helen S. Mueller, Colin E. Fowler, Simona Dalin, Enrico range expansions transition from Moiso, Tee Udomlumleart, Salil Garg, Michael T. Hemann, and Jacqueline A. Lees pushed to pulled Gabriel Birzu, Oskar Hallatschek, and Kirill S. Korolev e2107204118 On randomly changing conformity bias in cultural transmission MICROBIOLOGY Kaleda K. Denton, Uri Liberman, and Marcus W. Feldman e2110714118 A recombinant herpes virus expressing e2107859118 Spatiotemporal evolution of the Jehol Biota: influenza hemagglutinin confers protection Responses to the North China craton and induces antibody-dependent destruction in the Early Cretaceous cellular cytotoxicity Zhonghe Zhou, Qingren Meng, Rixiang Zhu, Katherine Kaugars, Joseph Dardick, Anna Paula de and Min Wang Oliveira, Kayla A. Weiss, Regy Lukose, John Kim, Lawrence Leung, Saranathan Rajagopalan, Sydney e2026212118 Evolution and seed dormancy shape plant Wolin, Leor Akabas, David M. Knipe, Goran Bajic, genotypic structure through and William R. Jacobs Jr a successional cycle e2102435118 Inhibition of elastase enhances the Anurag A. Agrawal, Amy P. Hastings, and John L. Maron adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and GENETICS mucosal immunity e2110758118 TET2 as a tumor suppressor and therapeutic Eunsoo Kim, Zayed Attia, Rachel M. Woodfint, Cong target in T-cell acute lymphoblastic leukemia Zeng, Sun Hee Kim, Haley E. Steiner, Rajni Kant Shukla, Maike Bensberg, Olof Rundquist, Aida Selimovic, Namal P. M. Liyanage, Shristi Ghimire, Jianrong Li, Cathrine Lagerwall, Mikael Benson, Mika Gourapura J. Renukaradhya, Abhay R. Satoskar, Gustafsson, Hartmut Vogt, Antonio Lentini, Amal O. Amer, Shan-Lu Liu, Estelle Cormet-Boyaka, and Colm E. Nestor and Prosper N. Boyaka e2107408118 Structure of Usutu virus SAAR-1776 displays IMMUNOLOGY AND INFLAMMATION fusion loop asymmetry e2110190118 SAMD9L autoinflammatory or ataxia Baldeep Khare, Thomas Klose, Qianglin Fang, pancytopenia disease mutations Michael G. Rossmann, and Richard J. Kuhn activate cell-autonomous e2101952118 Structural insights into a novel family of translational repression integral membrane siderophore reductases Amanda J. Russell, Paul E. Gray, John B. Ziegler, Yae Inokentijs Josts, Katharina Veith, Vincent Normant, Jean Kim, Sandy Smith, William A. Sewell, Isabelle J. Schalk, and Henning Tidow and Christopher C. Goodnow e2025813118 Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation NEUROSCIENCE Catherine Larochelle, Beatrice Wasser, He´le`ne Jamann, Julian T. Lo¨ffel, Qiao-Ling Cui, Olivier Tastet, e2023381118 Noise-induced properties of active dendrites Miriam Schillner, Dirk Luchtman, Je´roˆme Birkenstock, Carl van Vreeswijk and Farzada Farkhooi Albrecht Stroh, Jack Antel, Stefan Bittner, e2101743118 Parallel hippocampal-parietal circuits for self- and Frauke Zipp and goal-oriented processing e2025257118 14-3-3ζ: A suppressor of Annie Zheng, David F. Montez, Scott Marek, inflammatory arthritis Adrian W. Gilmore, Dillan J. Newbold, Joshua Kim, Krista Chun, Jenna McGowan, Youjie Timothy O. Laumann, Benjamin P. Kay, Zhang, Piotr J. Czernik, Blair Mell, Bina Joe, Saurabh Nicole A. Seider, Andrew N. Van, Jacqueline M. Chattopadhyay, Joseph Holoshitz, Hampton, Dimitrios Alexopolous, Bradley L. and Ritu Chakravarti Schlaggar, Chad M. Sylvester, Deanna J. Greene, Joshua S. Shimony, Steven M. Nelson, Gagan S. e2104420118 Benzofuran sulfonates and small self-lipid Wig, Caterina Gratton, Kathleen B. McDermott, antigens activate type II NKT cells via CD1d Marcus E. Raichle, Evan M. Gordon, Catarina F. Almeida, Dylan G. M. Smith, Tan-Yun Cheng, and Nico U. F. Dosenbach Chris M. Harpur, Elena Batleska, Catriona V. Nguyen- Robertson, Tram Nguyen, Tamara Thelemann, e2106504118 Genome-wide screen identifies curli amyloid Scott J. J. Reddiex, Shihan Li, Sidonia B. G. Eckle, Ildiko fibril as a bacterial component promoting Van Rhijn, Jamie Rossjohn, Adam P. Uldrich, D. Branch host neurodegeneration Moody, Spencer J. Williams, Daniel G. Pellicci, Chenyin Wang (汪辰吟), Chun Yin Lau, Fuqiang Ma, and Dale I. Godfrey and Chaogu Zheng (郑超固)

Contents PNAS u August 24, 2021 u vol. 118 u no. 34 u vii Downloaded by guest on September 24, 2021 e2017779118 Inactivation of Hedgehog signal transduction CORRECTIONS in adult astrocytes results in region-specific – blood brain barrier defects BIOPHYSICS AND COMPUTATIONAL BIOLOGY, CELL Hui Wang, Zhiyan Xu, Ziyue Xia, Michael Rallo, Andrew BIOLOGY Duffy, and Michael P. Matise e2112702118 The mechanics and dynamics of cancer cells e2022792118 Oculo-retinal dynamics can explain the perception sensing noisy 3D contact guidance of minimal recognizable configurations Jihan Kim, Yuansheng Cao, Christopher Eddy, Youyuan Liron Zipora Gruber, Shimon Ullman, and Ehud Ahissar Deng, Herbert Levine, Wouter-Jan Rappel, and Bo Sun e2100579118 Syngap1 regulates experience-dependent cortical ensemble plasticity by promoting in CHEMISTRY vivo excitatory synapse strengthening e2112469118 The pervasive threat of lead (Pb) in drinking Nerea Llamosas, Sheldon D. Michaelson, Thomas water: Unmasking and pursuing scientific Vaissiere, Camilo Rojas, Courtney A. Miller, factors that govern lead release and Gavin Rumbaugh Raymond J. Santucci Jr and John R. Scully

PHARMACOLOGY ANTHROPOLOGY e2023572118 An outer-pore gate modulates the e2112613118 The genomics of ecological flexibility, large pharmacology of the TMEM16A channel brains, and long lives in capuchin monkeys Ria L. Dinsdale, Tanadet Pipatpolkai, Emilio revealed with fecalFACS Agostinelli, Angela J. Russell, Phillip J. Stansfeld, Joseph D. Orkin, Michael J. Montague, Daniela Tejada- and Paolo Tammaro Martinez, Marc de Manuel, Javier del Campo, Saul Cheves Hernandez, Anthony Di Fiore, Claudia Fontsere, Jason A. Hodgson, Mareike C. Janiak, Lukas F. K. Kuderna, PLANT BIOLOGY Esther Lizano, Maria Pia Martin, Yoshihito Niimura, George H. e2102885118 Cooperative recruitment of RDR6 by SGS3 and Perry, Carmen Soto Valverde, Jia Tang, Wesley C. Warren, Joa˜oPedrodeMagalha˜es, Shoji Kawamura, Toma`s SDE5 during small interfering RNA Marque`s-Bonet, Roman Krawetz, and Amanda D. Melin amplification in Arabidopsis Manabu Yoshikawa, Yong-Woon Han, Hirofumi Fujii, Shu Aizawa, Tatsuya Nishino, and Masayuki Ishikawa CELL BIOLOGY e2104997118 Dynamic localization of a helper NLR at the e2112652118 iRhom2 controls the substrate selectivity of plant–pathogen interface underpins stimulated ADAM17-dependent pathogen recognition ectodomain shedding Thorsten Maretzky, David R. McIlwain, Priya Darshinee Cian Duggan, Eleonora Moratto, Zachary Savage, A. Issuree, Xue Li, Jordi Malapeira, Sadaf Amin, Philipp Eranthika Hamilton, Hiroaki Adachi, Chih-Hang Wu, A. Lang, Tak W. Mak, and Carl P. Blobel Alexandre Y. Leary, Yasin Tumtas, Stephen M. Rothery, Abbas Maqbool, Seda Nohut, Toby Ross Martin, Sophien Kamoun, and Tolga Osman Bozkurt DEVELOPMENTAL BIOLOGY e2011900118 Reciprocal antagonistic regulation of E3 e2112780118 Autocrine regulation of ecdysone synthesis ligases controls ACC synthase stability by β3-octopamine receptor in the and responses to stress prothoracic gland is essential for Han Yong Lee, Hye Lin Park, Chanung Park, Yi-Chun Drosophila metamorphosis Chen, and Gyeong Mee Yoon Yuya Ohhara, Yuko Shimada-Niwa, Ryusuke Niwa, Yasunari Kayashima, Yoshiki Hayashi, Kazutaka Akagi, Hitoshi POPULATION BIOLOGY Ueda, Kimiko Yamakawa-Kobayashi, e2109229118 Asymptomatic SARS-CoV-2 infection: A and Satoru Kobayashi systematic review and meta-analysis Pratha Sah, Meagan C. Fitzpatrick, Charlotte F. Zimmer, SI CORRECTION Elaheh Abdollahi, Lyndon Juden-Kelly, Seyed M. Moghadas, Burton H. , and Alison P. Galvani PHYSICS e2112935118 Quantum approximate optimization of the long-range Ising model with a trapped-ion quantum simulator SUSTAINABILITY SCIENCE Guido Pagano, Aniruddha Bapat, Patrick Becker, Katherine S. e2100695118 Reproductive hyperallometry and managing Collins, Arinjoy De, Paul W. Hess, Harvey B. Kaplan, Antonis the world’s fisheries Kyprianidis, Wen Lin Tan, Christopher Baldwin, Lucas T. Dustin J. Marshall, Michael Bode, Marc Mangel, Robert Brady, Abhinav Deshpande, Fangli Liu, Stephen Jordan, Arlinghaus, and E. J. Dick Alexey V. Gorshkov, and Christopher Monroe

viii u www.pnas.org Contents Downloaded by guest on September 24, 2021