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The US BRAIN Initiative
The US BRAIN Initiative Brain Research through Advancing Innovative Neurotechnologies John Donoghue, Ph.D. member US BRAIN Geneva Professor Advisory Commi5ee to the NIH Director of Neuroscience Director 1 views expressed here are my own and not those of the US Government Why a US BRAIN Initiative? The Need Is Great § Brain disorders: #1 source of disability in U.S. – > 100 million Americans affected § Rates are increasing § Costs are increasing- § annual cost of dementia ~$200B § by 2050 >$1Trillion § Already equals cost of cancer and heart disease The cost of disorders of the brain in Europe amounts overall to €798 billion in 2010 Eur Neuropsych. (2011) 21, 817-779 WHO, 2008 The Challenge for the 21st Century We do NOT know enough about the brain source: Donoghue! 3 “The Next Great American Project” “So there is this enormous mystery waiPng to be unlocked, and the BRAIN IniPave will change that by giving sciensts the tools they need to get a dynamic picture of the brain in acCon and be5er understand how we think and how we learn and how we remember. And that knowledge could be – will be – transformave.” -- President Obama, April 2, 2013 4 US BRAIN Initiative “a public and private effort” + Private Investments 5 The NIH BRAIN ScienCfic Plan • NIH Advisory Committee to the Director- William Newsome, PhD (co-chair) Working Group Stanford University (scientists, federal officials) • Met 2013-14 • Broad input from Cornelia Bargmann, PhD scientific community (co-chair) The Rockefeller University • Released June 2014 FIRST FIVE YEARS SECOND FIVE YEARS Emphasize technology Emphasize discovery development driven science 6 Understanding the Brain as a SYSTEM To map the circuits of the brain, measure the fluctuang paerns of electrical and chemical acPvity flowing within those circuits, and understand how their interplay creates our unique cogniPve and behavioral capabiliPes. -
Cold Spring Harbor Symposia on Quantitative Biology, Volume LXXIX: Cognition
This is a free sample of content from Cold Spring Harbor Symposia on Quantitative Biology, Volume LXXIX: Cognition. Click here for more information on how to buy the book. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LXXIX Cognition symposium.cshlp.org Symposium organizers and Proceedings editors: Cori Bargmann (The Rockefeller University), Daphne Bavelier (University of Geneva, Switzerland, and University of Rochester), Terrence Sejnowski (The Salk Institute for Biological Studies), and David Stewart and Bruce Stillman (Cold Spring Harbor Laboratory) COLD SPRING HARBOR LABORATORY PRESS 2014 © 2014 by Cold Spring Harbor Laboratory Press. All rights reserved. This is a free sample of content from Cold Spring Harbor Symposia on Quantitative Biology, Volume LXXIX: Cognition. Click here for more information on how to buy the book. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LXXIX # 2014 by Cold Spring Harbor Laboratory Press International Standard Book Number 978-1-621821-26-7 (cloth) International Standard Book Number 978-1-621821-27-4 (paper) International Standard Serial Number 0091-7451 Library of Congress Catalog Card Number 34-8174 Printed in the United States of America All rights reserved COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY Founded in 1933 by REGINALD G. HARRIS Director of the Biological Laboratory 1924 to 1936 Previous Symposia Volumes I (1933) Surface Phenomena XXXIX (1974) Tumor Viruses II (1934) Aspects of Growth XL (1975) The Synapse III (1935) Photochemical Reactions XLI (1976) Origins -
Annual Report Fy 2018 Human Frontier Science Program Organization
APRIL 2017 APRIL 2018 — MARCH 2019 ANNUAL REPORT FY 2018 HUMAN FRONTIER SCIENCE PROGRAM ORGANIZATION The Human Frontier Science Program Organization (HFSPO) is unique, supporting international collaboration to undertake innovative, risky, basic research at the frontier of the life sciences. Special emphasis is given to the support and training of independent young investigators, beginning at the postdoctoral level. The Program is implemented by an international organisation, supported financially by Australia, Canada, France, Germany, India, Italy, Japan, the Republic of Korea, New Zealand, Norway, Singapore, Switzerland, the United Kingdom of Great Britain and Nothern Ireland, the United States of America, and the European Commission. Since 1990, over 7000 researchers from more than 70 countries have been supported. Of these, 28 HFSP awardees have gone on to receive the Nobel Prize. 2 The following documents are available on the HFSP website www.hfsp.org: Joint Communiqués (Tokyo 1992, Washington 1997, Berlin 2002, Bern 2004, Ottawa 2007, Canberra 2010, Brussels 2013, London 2016): https://www.hfsp.org/about/governance/membership Statutes of the International Human Frontier Science Program Organization: https://www.hfsp.org/about/governance/hfspo-statutes Guidelines for the participation of new members in HFSPO: https://www.hfsp.org/about/governance/membership General reviews of the HFSP (1996, 2001, 2006-2007, 2010, 2018): https://www.hfsp.org/about/strategy/reviews Updated and previous lists of awards, including titles and abstracts: -
Reviewers [PDF]
The Journal of Neuroscience, January 2013, 33(1) Acknowledgement For Reviewers 2012 The Editors depend heavily on outside reviewers in forming opinions about papers submitted to the Journal and would like to formally thank the following individuals for their help during the past year. Kjersti Aagaard Frederic Ambroggi Craig Atencio Izhar Bar-Gad Esther Aarts Céline Amiez Coleen Atkins Jose Bargas Michelle Aarts Bagrat Amirikian Lauren Atlas Steven Barger Lawrence Abbott Nurith Amitai David Attwell Cornelia Bargmann Brandon Abbs Yael Amitai Etienne Audinat Michael Barish Keiko Abe Martine Ammasari-Teule Anthony Auger Philip Barker Nobuhito Abe Katrin Amunts Vanessa Auld Neal Barmack Ted Abel Costas Anastassiou Jesús Avila Gilad Barnea Ute Abraham Beau Ances Karen Avraham Carol Barnes Wickliffe Abraham Richard Andersen Gautam Awatramani Steven Barnes Andrey Abramov Søren Andersen Edward Awh Sue Barnett Hermann Ackermann Adam Anderson Cenk Ayata Michael Barnett-Cowan David Adams Anne Anderson Anthony Azevedo Kevin Barnham Nii Addy Clare Anderson Rony Azouz Scott Barnham Arash Afraz Lucy Anderson Hiroko Baba Colin J. Barnstable Ariel Agmon Matthew Anderson Luiz Baccalá Scott Barnum Adan Aguirre Susan Anderson Stephen Baccus Ralf Baron Geoffrey Aguirre Anuska Andjelkovic Stephen A. Back Pascal Barone Ehud Ahissar Rodrigo Andrade Lars Bäckman Maureen Barr Alaa Ahmed Ole Andreassen Aldo Badiani Luis Barros James Aimone Michael Andres David Badre Andreas Bartels Cheryl Aine Michael Andresen Wolfgang Baehr David Bartés-Fas Michael Aitken Stephen Andrews Mathias Bähr Alison Barth Elias Aizenman Thomas Andrillon Bahador Bahrami Markus Barth Katerina Akassoglou Victor Anggono Richard Baines Simon Barthelme Schahram Akbarian Fabrice Ango Jaideep Bains Edward Bartlett Colin Akerman María Cecilia Angulo Wyeth Bair Timothy Bartness Huda Akil Laurent Aniksztejn Victoria Bajo-Lorenzana Marisa Bartolomei Michael Akins Lucio Annunziato David Baker Marlene Bartos Emre Aksay Daniel Ansari Harriet Baker Jason Bartz Kaat Alaerts Mark S. -
View Final Program
142nd ANNUAL MEETING OF THE AMERICAN ANA2017 NEUROLOGICAL ASSOCIATION SAN DIEGO, CA • OCTOBER 15-17, 2017 SHERATON SAN DIEGO HOTEL & MARINA EXPLORE • EXAMINE • INVESTIGATE FINAL PROGRAM OCTOBER 14, 2017 | Pre-Meeting Symposium: Big Science and the BRAIN Initiative 2017.MYANA.org 142nd ANNUAL MEETING OF THE AMERICAN ANA2017 NEUROLOGICAL ASSOCIATION SAN DIEGO, CA • OCTOBER 15 -17, 2017 SHERATON SAN DIEGO HOTEL & MARINA ND Please note some session titles may have changed since this program was printed. Please refer THE 142 ANA to your Mobile app for the most current session updates. ANNUAL MEETING LETTER FROM THE CHAIR 3 Enjoy outstanding scientific SCHEDULE AT A GLANCE 4 symposia covering the latest HOTEL FLOOR PLANS 6 research in the fields of neurology and neuroscience GENERAL INFORMATION 7 while taking the opportunity WIRELESS CONNECTION 8 to network with leaders in the world of academic neurology CONTINUING MEDICAL EDUCATION 8 at the 142nd ANA Annual ANNUAL MEETING MOBILE APP 8 Meeting in San Diego, CA, October 15-17, 2017. PROGRAMS BY DAY 9 SATURDAY OCT 14 9 MEETING LOCATION SUNDAY OCT 15 9 Sheraton San Diego MONDAY OCT 16 17 Hotel & Marina 1380 Harbor Island Drive TUESDAY OCT 17 25 San Diego, California 92101 IN MEMORIAM 28 ONSITE MEETING CONTACTS SPEAKER ABSTRACTS 29 Registration and meeting questions: THANK YOU TO OUR SUPPORTERS & EXHIBITORS 42 [email protected] FUTURE MEETING DATES 42 OR visit the registration desk Bay View Foyer 2017 AWARDEES 43 (located in Marina Tower Lobby Level) ACADEMIC NEUROLOGY REPRESENTATIVES FROM JAPAN 47 Saturday, October 14 2017 ABSTRACT REVIEWERS 48 3:00 PM–7:00 PM BOARD OF DIRECTORS 49 Sunday, October 15 6:00 AM–5:45 PM ANA 2017 COMMITTEES, SUBCOMMITTEES & TASK FORCES 50 Monday, October 16 6:30 AM–5:45 PM Tuesday, October 17 6:30 AM–2:15 PM #ANAMTG2017 ANA 2017 FROM THE CHAIR Dear Colleagues, It is a pleasure to welcome you to the 142nd Annual Meeting of the American Neurological Association (ANA). -
3 and 4/1998 Genetic Engineering and Biotechnology
OCCASION This publication has been made available to the public on the occasion of the 50th anniversary of the United Nations Industrial Development Organisation. DISCLAIMER This document has been produced without formal United Nations editing. The designations employed and the presentation of the material in this document do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations Industrial Development Organization (UNIDO) concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries, or its economic system or degree of development. Designations such as “developed”, “industrialized” and “developing” are intended for statistical convenience and do not necessarily express a judgment about the stage reached by a particular country or area in the development process. Mention of firm names or commercial products does not constitute an endorsement by UNIDO. FAIR USE POLICY Any part of this publication may be quoted and referenced for educational and research purposes without additional permission from UNIDO. However, those who make use of quoting and referencing this publication are requested to follow the Fair Use Policy of giving due credit to UNIDO. CONTACT Please contact [email protected] for further information concerning UNIDO publications. For more information about UNIDO, please visit us at www.unido.org UNITED NATIONS INDUSTRIAL DEVELOPMENT ORGANIZATION Vienna International Centre, P.O. Box 300, 1400 Vienna, Austria Tel: (+43-1) 26026-0 · www.unido.org · [email protected] EMERGING TECHNOLOGY SERIES 3 and 4/1998 Genetic Engineering and Biotechnology UNITED NATIONS INDUSTRIAL DEVELOPMENT ORGANIZATION Vienna, 1999 TO OUR READERS EMERGING TECHNOLOGY SERIES: Globalization, the information society, sustainable development: these are the keywords of the day. -
Dynamics of Excitatory-Inhibitory Neuronal Networks With
I (X;Y) = S(X) - S(X|Y) in c ≈ p + N r V(t) = V 0 + ∫ dτZ 1(τ)I(t-τ) P(N) = 1 V= R I N! λ N e -λ www.cosyne.org R j = R = P( Ψ, υ) + Mγ (Ψ, υ) σ n D +∑ j n k D k n MAIN MEETING Salt Lake City, UT Feb 27 - Mar 2 ................................................................................................................................................................................................................. Program Summary Thursday, 27 February 4:00 pm Registration opens 5:30 pm Welcome reception 6:20 pm Opening remarks 6:30 pm Session 1: Keynote Invited speaker: Thomas Jessell 7:30 pm Poster Session I Friday, 28 February 7:30 am Breakfast 8:30 am Session 2: Circuits I: From wiring to function Invited speaker: Thomas Mrsic-Flogel; 3 accepted talks 10:30 am Session 3: Circuits II: Population recording Invited speaker: Elad Schneidman; 3 accepted talks 12:00 pm Lunch break 2:00 pm Session 4: Circuits III: Network models 5 accepted talks 3:45 pm Session 5: Navigation: From phenomenon to mechanism Invited speakers: Nachum Ulanovsky, Jeffrey Magee; 1 accepted talk 5:30 pm Dinner break 7:30 pm Poster Session II Saturday, 1 March 7:30 am Breakfast 8:30 am Session 6: Behavior I: Dissecting innate movement Invited speaker: Hopi Hoekstra; 3 accepted talks 10:30 am Session 7: Behavior II: Motor learning Invited speaker: Rui Costa; 2 accepted talks 11:45 am Lunch break 2:00 pm Session 8: Behavior III: Motor performance Invited speaker: John Krakauer; 2 accepted talks 3:45 pm Session 9: Reward: Learning and prediction Invited speaker: Yael -
As the Worm Turns with the Help of a Tiny Worm, Cornelia Bargmann Is Unpicking the Neural Circuits That Drive Eating, Socializing and Sex
NEWS FEATURE As the worm turns With the help of a tiny worm, Cornelia Bargmann is unpicking the neural circuits that drive eating, socializing and sex. BY STEPHEN S. HALL ale sexual dysfunction is never pretty, even in nematodes. every animal has to show and every animal has to solve?” she asks. “You In normal roundworm courtship, a slender male will sidle can basically say that the three would be hunger, fear and reproduction. up to a plump hermaphrodite, make contact, and then ini- None of those things got invented last Saturday night!” tiate a set of steps leading up to insemination: a sinuous The evolutionary strength of that argument grew last year, when Mbackwards motion as he searches for the sexual cleft, a pause to probe, Bargmann and her colleagues published the experiments with the and finally the transfer of sperm. The whole business is usually over in mutant males1. The mutation, they reported, is in a roundworm gene a couple of minutes. “It’s very slithery, and affectionate,” says Cornelia that they dubbed nematocin, which codes for a small peptide that influ- Bargmann, who has been observing the behaviour of this particular ences multiple neurons and is a biochemical cousin to oxytocin and vas- worm, Caenorhabditis elegans, for 25 years. opressin, two hormones that play key parts in mammalian reproductive Last October, scientists in Bargmann’s laboratory at the Rockefeller behaviour. Put another, Darwinian, way, the sexual confusion in mutant University, New York, reported the discovery of a gene that seems to be nematode males is tied to a molecule that seems to have been conserved crucial to successful mating. -
Jacob and Louise Gabbay Award in Biotechnology and Medicine in 2016 to Honor Jacob’S Wife, Louise Gabbay, Who Was Instrumental in Founding the Award
JACOB AND LOUISE JACOB AND LOUISE GABBAY AWARDGABBAY AWARD IN BIOTECHNOLOGY IN BIOTECHNOLOGYAND MEDICINE AND MEDICINE PRESENTATION CEREMONY 19th THURSDAY, SEPTEMBER 29, 2016 Annual WALTHAM, MASS. BRANDEIS UNIVERSITY Early in 1998, the trustees of the Jacob and Louise Gabbay Foundation decided to establish a major new award in basic and applied biomedical sciences. The foundation felt that existing scientific awards tended to honor people who were already well-recognized or to focus on work that had its primary impact in traditional basic research fields. Yet the history of science suggests that most scientific revolu- tions are sparked by advances in practical areas such as instrumentation and techniques or through entrepreneurial endeavors. The foundation therefore created the Jacob Heskel Gabbay Award in Biotechnology and Medicine to recognize, as early as possible in their careers, scientists in academia, medicine or industry whose work had both outstanding scientific content and significant practical consequences in the biomedical sciences. The award was renamed the Jacob and Louise Gabbay Award in Biotechnology and Medicine in 2016 to honor Jacob’s wife, Louise Gabbay, who was instrumental in founding the award. Because of their long association with Brandeis University, the trustees of the foundation asked the Rosenstiel Basic Medical Sciences Research Center at Brandeis to administer the award. The award, given annually, consists of a $15,000 cash prize (to be shared in the case of multiple winners) and a medallion. The honorees travel to Brandeis University each fall to present lectures on their work and attend a dinner at which the formal commendation takes place. This year, a committee of distinguished scientists selected Jeffery Kelly of the Scripps Research Institute for his profound and paradigm-shifting contri- butions to our understanding of protein-folding mechanisms and protein-folding diseases. -
The BBVA Foundation Frontiers of Knowledge Award Goes to the Architects of Optogenetics, Which Uses Light to Probe and Modulate the Workings of the Brain
Three neuroscientists win the Biomedicine award The BBVA Foundation Frontiers of Knowledge Award goes to the architects of optogenetics, which uses light to probe and modulate the workings of the brain Edward Boyden, Karl Deisseroth and Gero Miesenböck developed and refined a technique that employs light to activate and inactivate proteins in the brain cells, making it possible to modulate their activity with unprecedented precision Optogenetics is now a widely used tool being applied to elucidate functions like sleep, appetite and movement or reward circuits in addiction The awardees all emphasize the basic knowledge underpinning the technique, which, they say, will eventually yield new opportunities in the clinic Madrid, January 26, 2016.- The BBVA Foundation Frontiers of Knowledge Award in Biomedicine goes in this eighth edition to neuroscientists Edward Boyden, Karl Deisseroth and Gero Miesenböck for the development of optogenetics, a method to study brain function with unprecedented resolution. In a bare five years, thousands of groups the world over have begun using optogenetics to investigate functions like sleep, appetite, decision-making, temporal perception or the creation of memories, and elucidate the mechanisms of conditions such as epilepsy, Parkinson’s, depression and certain forms of blindness. The beauty of optogenetics is that it allows the selective control of neural activity simply by applying light of the right wavelength. Before, the most widely used methods to study the living brain could modulate the activity of hundreds of thousands of neurons, but with little selectivity. With optogenetics, it is possible to act exclusively on neurons treated previously with light-sensitive proteins, according to the behavior being tested. -
Studies in Physics, Brain Science Earn $1 Million Awards 2 June 2016, by Malcolm Ritter
Studies in physics, brain science earn $1 million awards 2 June 2016, by Malcolm Ritter Nine scientists will share three $1 million prizes for More information: Kavli Prizes: discoveries in how the brain can change over time, www.kavliprize.org how to move individual atoms around and how Albert Einstein was right again about the universe. © 2016 The Associated Press. All rights reserved. The Norwegian Academy of Science and Letters in Oslo on Thursday announced the winners of the Kavli Prizes, which are bestowed once every two years. The prize for astrophysics is shared by Ronald Drever and Kip Thorne of the California Institute of Technology and Rainer Weiss of the Massachusetts Institute of Technology. They were cited for the first direct detection of gravity waves, tiny ripples that spread through the universe. Einstein had predicted a century ago that the waves exist; the announcement that they'd been observed made headlines in February. The neuroscience prize is shared by Eve Marder of Brandeis University in Waltham, Massachusetts, Michael Merzenich of the University of California, San Francisco, and Carla Shatz of Stanford University. They were honored for discoveries in showing how the brain changes during learning and development, even as it keeps some basic stability over time. The prize for nanoscience—the study of structures smaller than bacteria for example—goes to Gerd Binnig of the IBM Zurich Research Laboratory in Switzerland, Christoph Gerber of the University of Basel in Switzerland and Calvin Quate of Stanford. They were honored for atomic force microscopy, a technique now widely used that can reveal the arrangement of individual atoms on a surface and remove, add or rearrange them. -
Biography of Cornelia I. Bargmann BIOGRAPHY
Corrections MEDICAL SCIENCES. For the article ‘‘HLA-B*5801 allele as a BIOGRAPHY, NEUROSCIENCE. For the article ‘‘Biography of Cornelia genetic marker for severe cutaneous adverse reactions caused by I. Bargmann,’’ by Melissa Marino, which appeared in issue 9, allopurinol,’’ by Shuen-Iu Hung, Wen-Hung Chung, Lieh-Bang March 1, 2005, of Proc. Natl. Acad. Sci. USA (102, 3181–3183; Liou, Chen-Chung Chu, Marie Lin, Hsien-Ping Huang, Yen- first published February 22, 2005; 10.1073͞pnas.0500025102), Ling Lin, Joung-Liang Lan, Li-Cheng Yang, Hong-Shang Hong, due to an editorial office error, the term ‘‘roundworm’’ was Ming-Jing Chen, Ping-Chin Lai, Mai-Szu Wu, Chia-Yu Chu, incorrectly replaced with ‘‘flatworm’’ in the first sentence. The Kuo-Hsien Wang, Chien-Hsiun Chen, Cathy S. J. Fann, Jer- correct sentence should read as follows: ‘‘In the unhearing, Yuarn Wu, and Yuan-Tsong Chen, which appeared in issue 11, unseeing world of the roundworm Caenorhabditis elegans, its March 15, 2005, of Proc. Natl. Acad. Sci. USA (102, 4134–4139; sense of smell is its lifeline.’’ first published March 2, 2005; 10.1073͞pnas.0409500102), due to ͞ ͞ ͞ ͞ a printer’s error, the symbols in the affiliation line appeared www.pnas.org cgi doi 10.1073 pnas.0502717102 incorrectly. The corrected affiliation line appears below. aInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan; Departments of cDermatology, eRheumatology, Allergy, and Immunology, and hNephrology, Chang Gung Memorial Hospital, Taipei 10507, Taiwan; fDepartment of Medical Research,