Table S1. List of Potential Positive and Negative Regulators of Telomerase

Table S1. List of potential positive and negative regulators of telomerase.

Potential positive regulators RTA(%) Gene symbol Name Rep1 Rep2 FGFR3 fibroblast growth factor receptor 3 1.26 5.52 MAPK3 ERK1, mitogen activated protein kinase 3 1.39 0.25 RAC1 Ras-related, migration-inducing gene 5 1.75 0.22 PNKP polynucleotide kinase 3’-phosphatase 1.91 0.02 BMP2K BMP2 inducible kinase 3.74 0.01 MST4 STE20-like kinase 4.19 2.55 MAPK1 ERK2, mitogen activated protein kinase 1 4.63 8.54 FGFR4 fibrablast growth factor receptor 4 4.71 16.58 nr FES feline sarcoma oncogene 5.38 6.41 RPS6KA5 ribosomal protein S6 kinase, polypeptide 5 5.86 9.64 TNIK TRAF2 and NCK interacting kinase 6.27 10.38 DTYMK deoxythymidylate kinase 7.84 4.38 LYK5 STE20-related adaptor protein 8.92 16.38 DLG4 disc, large homolog 4, chapsyn-110 10.4 3.59 ERK8 MAPK15, extracellular regulated kinase 8 delta 10.44 3.59 MPZL1 myelin protein zero-like 1 10.95 0.49 STK19 serine/threonine kinase 19 11.16 4.33 ADCK4 aarF domain containing kinase 4 11.17 3.99 NEK2 NIMA (never in mitosis gene)-related kinase 2 11.22 22.58 NEK6 NIMA-related kinase 6 11.40 14.01 IRAK1 interleukin-1 receptor-associated kinase 1 12.15 0.07 CCRK cell cycle related kinase 12.56 4.30 nr PAK7 P21-activated kinase 7 13.46 1.17 NEK7 NIMA-related kinase 7 14.12 8.43 CDKL2 cyclin-dependent kinase-like 2 14.19 24.48 SAST microtubule associated serine/threonine kinase 1 14.29 34.36 MAP3K4 MAP protein kinase kinase kinase 4 15.00 10.92 PRKAR2B protein kinase, cAMP-dependent type II beta 15.16 1.35 DNAJC3 DNAJ (Hsp40) homolog, subfamily C, member 3 15.18 22.71 RPS6KA4 ribosomal protein S6 kinease, polypeptide 4 15.28 23.94 nr STK29 serine/threonine kinase 29 15.96 14.78 CD7 CD7 molecule 16.11 28.25 GAP43 growth associated protein 43 16.56 1.58 SOCS1 JAK binding protein 16.61 0.02 CHEK2 CHK2 checkpoint homolog 16.86 2.02 nr BDKRB2 bradykin receptor B2 16.95 4.32 AVPR1B arginine vasopressin receptor 1B 17.34 10.86 EDN2 endothelin 2 17.35 4.03 NEK8 NIMA-related kinase 8 17.67 10.96 nr EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 18.07 8.85 MAPK14 P38 MAP kinase, stress-activated protein kinase 2A 18.24 3.58 nr IHPK3 inositol hexaphosphate kinase 3 18.50 1.28 CDKN2B cyclin-dependent kinase inhibitor 2B 18.93 24.16 EPHA4 ephrin receptor A4 19.67 4.45 DMPK dystrophia myotonica-protein kinase 19.70 10.73 DKFZp434C1418 20.77 5.64 GNE glucosamine 2-epimerase/N-acetylmannosamine k 20.94 0.57 ROCK2 Rho-associated coiled-coil protein kinase 2 21.41 12.73 APPL AKT2 interactor 21.44 1.51 PRKCQ protein kinase C, theta 21.47 30.24 ANGPT4 angiopoietin 4 22.56 5.24 CHEK1 CHK1 checkpoint homolog 22.76 7.81 nr PRKD2 protein kinase D2 23.01 19.12 YES1 Yamaguchi sarcoma viral oncogene homolog 1 23.04 25.01 SPA17 sperm autoantigenic protein 17 23.61 1.15 PTPRG protein tyrosine phosphatase G 23.62 0.10 DUSP10 dual specificity phospatase MKP-5 23.64 4.69 FLJ12476 23.88 10.09 AURKB Aurora Kinase B 26.6 33.51 NEK4 NIMA-related kinase 4 27.04 22.59 C7ORF16 chromosome 7 open reading frame 16 27.22 12.17 PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide 27.36 13.56 CLK3 CDC-like kinase 3 27.83 22.21 P15RS cyclin-dependent kinase inhibitor-related protein 28.15 11.18 CSNK2A1 casein kinase 2, alpha 1 polypeptide 28.28 22.01 UGP2 UDP-glucose pyrophosphorylase 2 28.30 3.35 JAK2 Janus kinase 2 28.38 1.28 nr MET Met proto-oncogene 28.40 10.23 nr DLG2 discs, large homolog 2, chapsyn-110 28.52 20.97 ATR ataxia telengiectasia and Rad3-related 30.75 2.37 CAMK2A calcium/calmodulin-dependent kinase 30.98 2.37 CASK calcium/calmodulin serine/threonine kinase 31.03 9.79 KSR2 connector enhancer of kinase suppressor of Ras 2 31.12 1.90 DCK deoxycytidine kinase 31.15 27.32 YWHAQ 14-3-3 protein T-cell tau 31.92 0.44 nr MA2K7 MAPKK7, JNK-activating kinase 2 32.10 12.90 AKAP8 A kinase (PRKA) anchor protein 8 32.22 32.52 nr NTRK1 neurotrophic tyrosine kinase, receptor type 1 32.69 29.71 IKBKAP IKK-complex-associated protein IKAP 32.70 15.24 MVK mevalonate kinase 32.98 4.02 PRKCSH protein kinase C substrate 80K-H 33.39 14.96 STK16 serine/threonine kinase 16 33.44 26.99 LCP2 lymphocyte cytosolic protein 2 33.84 28.65 MALT1 MALT-lymphoma associated translocation kinase 34.22 5.77 PRKAR2A protein kinase, cAMP-dependent, type II alpha 34.51 25.47 PPP1R1B protein phosphatise 1, inhibitor subunit 1B 34.55 0.57 PKIB protein kinase (cAMP-dependent) inhibitor beta 34.75 8.03 MAPKAPK5 MAPK-activated protein kinase 5 34.78 21.33 MAP3K3 MAP protein kinase kinase kinase 3 3.36 MAP3K2 MAP protein kinase kinase kinase 2 5.06 MAP3K1 MAP protein kinase kinase kinase 1 22.55

Potential negative regulators SRC v-sarcoma viral oncogene homolog 130.65 155.92 SPHK2 sphingosine kinase 2 151.02 216.74 PCK1 phosphoenolpyruvate carboxykinase 1 155.06 469.21 PI4K2B phosphatidylinositol 4-kinase type 2 beta 159.57 528.00 CAMK2G calcium/calmodulin-dependent protein kinase 168.87 356.13 nr MAP4K3 MAP kinase kinase kinase kinase 3 171.02 244.71 FLJ35107 173.97 300.16 CERK ceramide kinase 194.04 287.85 MAPK8 MAP kinase 8, JNK1 199.03 169.77 nr RYK RYK receptor-like tyrosine kinase 199.87 442.10 MAP3K5 MAP kinase kinase kinase 5 202.30 196.30 RAPGEF3 rap guanine nucleotide exchange factor 3 205.16 344.53 SEPHS2 selenophosphate synthetase 2 213.77 301.92 MGC5601 235.71 341.00 FLJ13052 NAD kinase 251.24 268.98 IPTK1 inositol 1,3,4-triphosphate 5/6 kinase 293.33 496.49 RPS6KB2 ribosomal protein S6 kinase B2 295.50 345.82 ROCK1 Rho-associated coiled-coil protein kinase 343.73 254.32 Kinases in bold were further analyzed; nr, kinases that did not revalidate.