st 126BMODULE 1 Semester Hours/Semester L P ECTS Molecules, Cells, Tissues (including Histology, 1st Embryology, Molecular Biology, Genetics, 89 43 13.5 Chemistry, Biochemistry, Physiology) 3rd (Ι) Biostatistics 18 12 3.0

3rd (Ι) Informatics (score grading not required) 12 1.0

3rd (Ι) Foreign language terminology 24 3.0

Introduction to the Veterinary Science (score 3rd (Ι) 3 grading not required)

Animal Science Ι (including General Animal 4th (I) Husbandry, Welfare & Animal behaviour, 31 30 6.0 Ecology and Protection of the Environment) Total 165 97 26.5

Instructors of 1st Semester Modules Angelopoulou Katerina Κ.Α. Arsenos George G.Α. Banos George G.B. Batzios Christos C.B. Botsoglou Nikolaos N.B. Dori Ioanna I.D. Flaskos John J.F. Fortomaris Paschalis P.F. Georgiadis Marios Μ.G. Kamarianos Athanasios Α.Κ. Karamanlis Xanthippos X.Κ. Lavrentiadou Sofia S.L. Stamataris Constantinos C.S. Tserveni‐Gousi Angeliki A.T. ‐ G Valergakis George G.V.

9 1st Module ‐ 1st Semester

127BMolecules, Cells, Tissues

Learning objectives This module aims to introduce students to the principles of chemistry, cellular and molecular biology, genetics, biochemistry, histology and embryology. The learning objectives include the understanding of the following concepts: • chemical bonds, stereochemistry, aqueous solutions, acids/bases, thermodynamics • cell structure and function • structure and function of biomolecules • transport via cell membranes and second messenger systems • flow of genetic information and heredity • histology of basic tissues • cell and body metabolism • embryological development and organogenesis

1st Section

128BA. Organization of the cell 1st hour The cell. Cytoplasm [Ι.D.] 2nd hour Structure of cell membrane. The “fluid mosaic model”. Endocytosis [Ι.D.] 3rd hour Mitochondria. Rough, smooth enoplasmic reticulum. Ribosomes [Ι.D.] 4th hour Golgi apparatus, lysosomes [Ι.D.] 5th hour Cytoskeleton. Cytoplasmic inclusions [Ι.D.] 6th hour Structure of the nucleus. Nuclear membrane, matrix, nycleolus [Ι.D.] 7th hour Cell cycle. Mitosis. Meiosis. Cell differentiation, cell death [Ι.D.] 2 hours Introduction to Microscopy (Histology) 2 hours Cell Structure (Histology)

129BΒ. Chemistry 8th hour Chemical bond. Intra ‐ and intermolecular bonds and forces. Bond polarization. Stereochemistry [K.A.] 9th hour Aqueous solutions, Diffusion, Osmosis. Acids, Bases, Salts, pH, pK, Buffer solutions [N.B.]

10 10th hour Bioenergetic. Principles of chemical thermodynamics [K.A.] 3 hours Practical courses in the preparation of various aqueous solutions including buffers 3 hours Practical courses in alkalimetry and acidimetry

130BC. Biomolecules Structure and Function 11th hour Amino acids. Classification and properties. Peptides [Κ.Α.] 2 hours Spectrophotometry (Biochemistry) 12th hour Proteins. Classification. Electrolytic behavior. Primary and secondary structure [Κ.Α.] 13th hour Proteins. Tertiary structure and conformation. Quaternary structure. Protein denaturation [Κ.Α.] 2 hours Spectrophotometric determination of glucose (Biochemistry) 14th hour Enzymes. Introduction to the enzymatic catalysis. Coenzymes ‐ vitamins ‐ metal ions. Classification and nomenclature [Κ.Α.] 15th hour Enzymes. Active site. Substrate binding. Specificity [Κ.Α.] 2 hours Spectrophotometric determination of protein (Biochemistry) 16th hour Enzymes. Enzyme kinetics. Michaelis ‐ Menten equation. Enzyme inhibition [Κ.Α.] 17th hour Regulation of enzymatic activity. Enzyme organization. Multienzyme complexes. Proenzymes. Allosteric enzymes. Isoenzymes [Κ.Α.] 2 hours Spectrophotometric determination of amylase in urine (Biochemistry) 18th hour Carbohydrates. Monosaccharites. Oligosaccharites. Polysaccharites (starch ‐ glycogen). Glycoproteins [Κ.Α.] 19th hour Lipids. Fatty acids. Acylglycerols. Posphoglycerides. Isoprenoids. Prostaglandins [Κ.Α.] 20th hour Nucleotides. The central role of ATP in energy exchanges. Energy transfer via reaction coupling [Κ.Α.]

131BD. Membranes and Cell Physiology 21st hour Membrane transport. Transport via protein carriers. Passive transport systems. Active transport systems [Κ.Α.] 22nd hour Membrane potential, resting membrane potential [S.L.] 23rd hour Membrane receptors. G‐proteins. Second messenger systems [K.A.]

132BE. Flow of Genetic Information and Heredity 24th hour Nucleic acid structure. The backbone of nucleic acids. The Watson ‐ Crick double helix. RNA secondary structure. DNA denaturation [Κ.Α.]

11 25th hour Chromatin (heterochromatin, euchromatin, sex chromatin, chromatin fibers). Nucleosomes. Organization of chromosomes. Karyotype [I.D.] 26th hour DNA replication. Replication enzymes. DNA repair. Inhibition of DNA replication [Κ.Α.] 27th hour DNA transcription. Transcription enzymes. Initiation, elongation and termination of RNA synthesis. Inhibition of transcription. Post ‐ transcriptional modifications [Κ.Α.] 28th hour The genetic code. Codon ‐ anticodon. Point mutations. Frameshift mutations [Κ.Α.] 29th hour Protein synthesis. Initiation, elongation and termination of polypeptide chain synthesis. Post ‐ translational modifications of polypeptide chains. Inhibition of protein synthesis [Κ.Α.] 30th hour Regulation of gene expression. The operon model. Characteristics of the lac promoter and operon sites. Enzyme induction and ihibition [Κ.Α.] 31th hour Applications of Genetics ‐ The polymerase chain reaction ‐ Resctriction enzymes, molecular markers, genetic maps [K.A.] 32nd hour Applications of Genetics ‐ Genetic engineering [K.A.] 2 hours Polymerase chain reaction (Molecular Biology‐Genetics) 2 hours Electrophoresis ‐ Restriction enzyme digestion (Molecular Biology ‐ Genetics)

2nd Section 33rd hour Structural and numerical chromosomal anomalies [G.B.] 34th hour Genome mapping, map types, applications. Historical account of developments in genetics [G.B.] 35th hour Mendel’s experiments. Segregation and independent assortment laws. Genotypic ratios [G.B.] 36th hour Relationships between alleles: dominance, dominance relations, one‐ side inheritance, over ‐ dominance [G.B.] 2 hours Single ‐ multiple‐trait inheritance (Molecular Biology ‐ Genetics) 37th hour Relationships between genes from different loci: Epistasis (7 types). Impact on phenotypic ratios [G.B.] 38th hour Gene linkage and recombination. Recombination rate. Lethal genes [G.B.] 2 hours Epistasis ‐ Gene linkage (Molecular Biology ‐ Genetics) 39th hour Relationship between sex and inheritance. Sex‐linked and partially sex‐linked genes; sex‐influenced and sex‐restricted traits. Single‐gene traits of interest to animal husbandry [G.B.]

12 2 hours Relationship between sex and inheritance (Molecular Biology ‐ Genetics) 40th hour Calculation of gene and genotypic frequency. Hardy ‐ Weinberg equilibrium rule under random mating; assumptions [G.B.] 41st hour Check and confirmation of populations in Hardy ‐ Weinberg equilibrium. Calculation of gene frequency in case of multiple alleles and sex‐linked loci [G.B.] 42nd hour Impact of natural selection, mutation, migration and genetic drift on gene frequency [G.B.] 2 hours Population genetics (Molecular Biology ‐ Genetics) 43rd hour Comparison between oligogenic and polygenic (quantitative) traits. Genotype ‐ environment relationship and interaction. Additive gene action. Variation and variance of genetic values and phenotypic records of farm animals [G.B.] 2 hours Estimation of genetic values and producing abilities (Molecular Biology ‐ Genetics) 44th hour Genetic parameters of traits (heritability, repeatability, genetic correlation). Pleiotropic gene actions [G.B.] 45th hour Study of genealogy trees and assessment of genetic relationships among individuals [G.B.] 1 hour Estimation of genetic relationships and inbreeding (Molecular Biology ‐ Genetics) 46th hour Genetic applications ‐ detection of recessive allele carriers [G.B.]

133BF. Body tissues (Tissue level of organization) 47th hour Epithelial tissue [Ι.D.] 48th hour Epithelial glands ‐ Glands (classification and organization of exocrine glands, endocrine glands) [Ι.D.] 2 hours Epithelial tissue (Histology) 49th hour Smooth muscle. Fine structure of smooth muscle fibers [I.D.] 50th‐51st hour Skeletal muscle. Fine structure of skeletal muscle fibers [I.D.] 2 hours Muscle tissue (smooth, skeletal, cardiac muscle) (Histology) 52nd‐53rd hour Molecular mechanism of muscle contraction [S.L.] 54th hour Cardiac muscle. Fine structure of cardiac muscle fibers. Impulse ‐ conducting system [I.D.] 55th hour Connective tissue. Matrix. Collagen, reticular, elastic fibers. Ground substance [I.D.]

13 56th hour Cells of connective tissue. Fibroblasts, adipose cells, mesenchymal cells, macrophages, mast cells, plasma cells, migrating cells [I.D.] 57th hour Types of connective tissue (dense, loose, mucus, elastic, reticular, adipose tissue) [I.D.] 2 hours Connective tissue (loose, dense, adipose, elastic) (Histology) 58th hour Cartilage (hyaline, elastic, fibrous cartilage) [I.D.] 59th hour Bone (osteocytes, osteoclasts, osteoblasts, bone matrix), Types of bone (primary, secondary bone) [I.D.] 2 hours Cartilage and bone (Histology)

3rd Section

134BG. Cell and Body Metabolism 60th hour Glycolysis [J.F.] 61st hour Glycolysis regulation. Importance of anaerobic glycolysis [J.F.] 62nd‐63rd hour Citric acid cycle and its regulation. Oxidation and reduction reactions [J.F.] 64th hour Respiratory chain. Oxidative phosphorylation [J.F.] 65th hour Gluconeogenesis from lactic acid and amino acids [J.F.] 66th hour Gluconeogenesis from glycerol. Glyoxylate cycle [J.F.] 67th hour Glycogenolysis and its regulation [J.F.] 68th hour Glycogen synthesis and its regulation [J.F.] 69th hour Blood glucose. Insulin and glucagon [J.F.] 70th hour Fatty acid oxidation [J.F.] 71st hour Lipolysis and its regulation. Ketone bodies [J.F.] 72nd hour Fatty acid biosynthesis and its regulation [J.F.] 73rd hour Triglyceride and phosphoglyceride metabolism [J.F.] 74th hour Cholesterol metabolism. Cholesterol biosynthesis and its regulation in the liver and extrahepatic tissues [J.F.] 75th hour Cholesterol metabolism. Bile acids. Cholesterol esters [J.F.] 76th hour Amino acid nitrogen metabolism. Uria cycle [J.F.] 77th‐78th hour Degradation of the amino acid carbon skeleton [J.F.] 79th hour Nucleotide metabolism [J.F.] 80th‐81st hour Metabolism in adipose tissue. Brown adipose tissue [J.F.] 82nd hour Skeletal muscle energy metabolism in relation to the nutritional status and at rest [J.F.] 83rd hour Skeletal muscle energy metabolism during exercise [J.F.]

135BΗ. Embryology 84th hour Basic principles of Embryology, gametogenesis, fertilization, zygote formation. Cleavage (partial, discoidal, superficial, total, unequal, equal), determination, mosaic and regulative eggs [Ι.D.] 85th hour Morula and blastula formation in birds and mammals [Ι.D.]

14 86th hour Developmental stages. Embryo transfer (cleavage, early morula, compact morula, early blastocyst, expanding blastocyst, hatching blastocyst, hatched blastocyst) stage. Gastrula formation (invagination, epiboly, delamination, migration). Formation of ectoderm, mesoderm, endoderm [Ι.D.] 87th hour Gastrulation in amphioxus, birds and mammals [Ι.D.] 88th hour Formation of germinal layers, tissues, organs. Mesenchyma: origin, migration and role of mesenchymal cells [Ι.D.] 89th hour Developmental mechanisms during morphogenesis, histogenesis, organogenesis: Induction, organizers. Formation of body, body cavities and limbs in birds and mammals [Ι.D.] 2 hours Embryonic development (Histology)

Grade Distribution of Practical Examination Histology, Embryology 80% Chemistry 20%

Final Grade Theory 70% Practicals 30%

15 3rd Module (Ι) ‐ 1st Semester

Learning objectives

1. Students should learn basic statistical principles and understand the notions of parameter, variability, population and sample. They should also understand the purpose of statistical inference and the role of computers in modern statistics

2. Students should learn to summarize data and produce data presentations, using graphs, tables and relevant statistical measures of central tendency, skewness and dispersion.

3. Students should become familiar with the notion of probability and learn some basic probability theory. They should also understand the ideas of frequency distribution and probability distribution learn the basic principles of sampling and understand the idea of a sampling distribution.

4. Students should learn the principles of statistical inference (estimation and hypothesis testing, both parametric and non‐parametric) and be able to perform relevant procedures, by hand and using a PC. Emphasis is given to the interpretation of SPSS output.

136BBiostatistics 1st hour Introduction to Statistics [C.B.] 1 The nature of Statistics 2 Computers and Statistical analysis 3 Subject matter and objectives of Statistics 4 Populations and samples 5 Basic Statistical terms (variable, observation, populations, samples, etc.) 2nd hour Presentation and classification of statistical data [C.B.] 4 Statistical tables and charts 5 Frequency distributions (continuous, discrete and qualitative variables) 6 Graphical presentation of frequency distributions 3rd‐5th hour Statistical measures [C.B.] 7 Basic measures of central tendency (arithmetical mean, weighted mean, median, mode, geometrical mean, etc.). Relationship between arithmetical mean, median and mode) 8 Choice of appropriate measure of central tendency 9 Measures of dispersion (range, interquartile range, variance, standard deviation, coefficient of variation, Tchebysheff’s theorem, empirical rule) 10 The effect of simple transformations on mean and variance 11 Measures of skewness, measures of curtosis 6th hour Elements of probability theory, random variables [C.B.]

16 12 Statistical experiment, test, events etc. 13 The meaning of probability (classical definition of probability, definition of probability as limit of relative frequency, definition of subjective probability, axiomatic definition of probability) 14 Calculation of probability, basic theorems of probability 15 Probability rules (multiplication rule, addition rule Bayes theorem) 16 Random variables and probability distributions (discrete and continuous probability distributions, discrete and continuous random variables) 7th‐9th hour Theoretical distributions [C.B.] 17 Discrete theoretical distributions (binomial distribution, Poisson distribution) 18 Continuous theoretical distributions (normal distribution, standard normal distribution Z, chi‐squared distribution, t distribution, F distribution) 10th‐11th hour Sampling (methods, distributions) [C.B.] 19 Principles of sampling (random and directed sampling) 20 Sampling distributions (of the mean of a proportion, of the difference between two means, of the variance etc.) 12th hour Estimation [C.B.] 21 Point and interval estimation 22 Confidence interval 23 Sampling errors 24 Determination of sample size 13th‐14th hour Statistical hypothesis testing [C.B.] 25 Statistical hypotheses 26 Hypothesis test about a mean and the difference between two means 27 Hypothesis test of the variance and the ratio of two variances 28 Hypothesis test of the proportion and the difference between two proportions 15th hour Analysis of frequencies [C.B.] 29 Test of goodness‐of‐fit 30 Test of independence 31 Test of homogeneity 16th hour Non‐parametric hypothesis tests [C.B., M.G.] 32 Test of goodness‐of‐fit (K‐S) 33 Tests for two samples, tests for k samples 17th hour General principles of analysis of variance [A.Y.] 34 Simple and factorial analysis 18th hour Simple regression and correlation [C.B.] 35 Least squares method 36 Interpretation of the regression equation 37 Linear correlation

17 0BPracticals 3 hours Construction of distribution tables with classification of data for continuous and discrete variables of Veterinary Science interest. Methods of graphical presentation of frequency distributions (histograms, rabdograms, polygonal lines). Examples of calculation of descriptive measures of central tendency. Choice of appropriate measure of central tendency. Applications of calculation of statistical measures of dispersion, skewness and curtosis [C.B.] 3 hours Calculation of probability. Examples of use of tables of theoretical distributions (binomial distribution, Poisson distribution, Z distribution, t distribution, chi‐squared distribution, F distribution). Sampling distribution of the mean, of the proportion, the difference between two means, the difference between two proportions, the variance. Problems of calculation of probability and sampling error when sampling with and without replacement. Applications of the central limit theorem [C.B.] 3 hours Calculation of confidence interval of the mean, the variance, the difference between two means, the proportions etc. Problems of sample size calculation when the objective is the estimation of the mean or the proportion in simple random and stratified random sampling. Problems of hypothesis testing for the mean, the difference between two means, the proportion, the difference between two proportions, the variance, the ratio of two variances. Statistical inference [C.B.] 3 hours Problems of testing goodness‐of‐fit, of analysis of frequencies with application of test for independence and homogeneity for the analysis of epizootiological problems in classification tables 2x2 2xc, rxc. Estimation of linear regression models for variables from various areas of Veterinary Science. Interpretation of regression equations, statistical inference of the results. Problems of simple and factorial analysis of variance, with emphasis on interpretation of results. Non‐ parametrical analysis. Statistical packages SPSS, TSP [C.B., M.G.]

18

4th (Ι) Module ‐ 1ο Semester

Animal Science I Learning objectives

1. Familiarisation with general aspects of animal husbandry and production, across all species of livestock. Knowledge of the diverse use of animals in society. 2. Knowledge of the importance of good animal husbandry in running a successful livestock operation or other animal holding facility as well as the role that good animal husbandry plays in preventing disease and behavioural problems. 3. Practical experience and skills in physical handling of farm animals of all species. 4. Knowledge of normal and abnormal animal behaviour and of behavioural responses to diseases. 5. Understanding the healthy growth patterns, especially as they apply to food animals and performance. 6. Knowledge of the Ecological Systems, flow of energy and productivity of Ecosystems and Bio‐geochemical cycles. 7. Skills and experience in Environmental pollution of aquatic and terrestrial ecosystems. 8. Knowledge of the interactions between Environmental pollution and animal production, including aquacultures. 9. Skills and experience in livestock waste management and knowledge of the interaction of the environment with proper husbandry.

1st Section

137BA. General Animal Husbandry 1st hour Objective, significance and mission of Animal Husbandry [G.V.] 2nd hour Problems and trends in Animal Production in the European Union. Animal Production in Greece, the European Union and Worldwide; current situation and trend analysis [G.V., C.B.] 3rd hour Relationship between genotype and the environment. [G.B.] 4th hour Impact of climate on morphological and productive traits of farm animals (reproduction, growth, milk production, egg production, wool production) [G.B.] 5th hour Impact of nutrition on productive traits of farm animals (reproduction, growth, milk production, egg production, wool production) [G.A.]

19 6th hour Origin and distribution of farm animal species; impact of domestication on farm animals (changes in morphology, physiology and psychology). Re‐introduction to the wild. Farm animal classification [G.V.] 7th hour Species, breeds (evolution and sub‐divisions) [G.V.] 8th hour Breed standards and herdbooks [G.B.] 9th‐11th hour Productive characteristics: Reproduction, Milk Production, Meat Production, Egg Production, Wool Production, Draft Power, Athletic Ability [G.A.] 12th hour Animal ethology: Subject, significance and recording [A.T.‐ G.] 13th hour Animal welfare needs [A.T.‐G.] 14th hour General measurements and evaluation of animal welfare; measurements related to (i) animal behaviour and (ii) function of various systems and organs. Tests for preference and aversion, behavioural deprivation, and assessment of motives, stereotypes, brain, heart etc. [G.A.] 15th hour Animal handling and transportation [G.A.]

2nd Section 16th hour Genetic improvement of farm animals; goal, significance and basic principles [G.B.] 17th hour Farm animal production systems (extensive, semi‐ extensive, semi‐intensive, intensive) and strategies [G.V.] 18th hour Basic principles of organic animal farming [G.A.] 19th hour General principles of animal farm buildings (location, soil, orientation, infrastructure, barns, stables, auxiliary areas). Animal farm hygiene in relation to the environment (health and healthy animal characteristics, factors affecting animal health and protection) [P.F., M.G.]

138BEcology and Protection of Environment 20th hour Introduction to Environmental Science (systems, cybernetic systems, biological systems, Gaia hypothesis, structure of ecosystems, biological community, abiotic elements of ecosystems) [A.K.] 21st hour Energy and Productivity of Ecosystems (solar radiation, consumption of energy from plant and animal organisms, thermodynamic laws, primary production, ecosystems productivity and influencing factors, energy flow in ecosystems, trophic relationships, ecological pyramids) [A.K., X.K.] 22nd hour Biogeochemical cycles (water cycle, oxygen cycle, carbon cycle, nitrogen cycle, phosphorus cycle, sulfur cycle) [X.K.] 23rd hour Population dynamics (population growth, environmental resistance, carrying capacity of the environment, population

20 regulation, interactions between species, ecological succession). Ecosystems (terrestrial biomes, marine biomes, freshwater biomes, lotic and lentic biomes, wetlands) [A.K.] 24th hour Pollution and Protection of Environment (demography, food production and the environment, urbanization, living standards and relative problems, global food production and environmental problems, optimization of primary food production and feeds, farm animals production and the environment, use and management of aquatic resources) [A.K.] 25th hour Environment and farm animal production (environmental pollution impacts on animal production, soil quality–soil pollution, soil acidification soil erosion on animal production) [A.K.] 26th hour Water quality and farm animal production (pollution, acidification, salinization of hydrosphere) [A.K.] 27th hour Air quality and farm animal production (air pollution by sulfur, carbon nitrogen oxides, ammonia, aerosols and heavy metals) [A.K.] 28th hour Agricultural and animal wastes (agricultural wastes, animal wastes, composition and characteristics of (i) animal wastes, (ii) effluents of animal originated product plants) [X.K.] 29th hour Impacts on human and animal health by environmental pollution caused by agricultural and animal wastes [X.K.] 30th hour Animal waste management (handling, treatment, disposal and utilization of animal wastes: fertilizers, feedstuff, energy) [X.K.] 31st hour Environmental protection policy on a Global, European and National level [X.K.]

Practicals 10 hours Animal identification, approaching and handling (sheep, goats, horses, cattle, swine, poultry). Identification of body areas of farm animals [A.T.‐ G, G.B., G.A., P.F., C.S., G.V.]

1. Sheep (2 hours)* 2. Goats (2 hours)* 3. Cattle (2 hours) 4. Equines (2 hours) 5. Pigs – poultry (2 hours) 4 hours Applications of genetic improvement programs [A.T.‐G, G.B., G.A., P.F., C.S., G.V.] 4 hours* Description and assessment of animal farms and buildings. Operation and management of zootechnical enterprises [A.T.‐ G,B. G. , G.A., P.F., C.S., G.V.] 2 hours Changes on the quality of aquatic ecosystems caused by pollution [A.K., X.K.]

21 2 hours Waste treatment methods, waste utilization [A.K., X.K.] 2 hours Evaluation of animal waste pollution potential. Changes of the diluted oxygen concentration [A.K., X.K.] 3 hours Impacts on natural environment by anthropogenic productive activities (wetlands of Axios, Loudias and Aliakmonas estuaries) [A.K., X.K.] 3 hours Aerobic and anaerobic wastewater treatment .,plants [A.K X.K.]

*The practical exercises take place in the Farm of the School in Kolchico, Lagadas.

MODULE 2nd Semester Hours/semester

84BL P ECTS Structure and Function of Body Systems Ι (including the basic principals of Pharmacology and 2nd the Anatomy, Physiology, Biochemistry and 94 88 16.5 Pharmacology of the Sensory Organs, of the Locomotor System, the Nervous System and the Endocrine System) Animal Science ΙΙ (including Animal Production 4th (ΙΙ) Economics and Fundamentals of Animal Nutrition) 28 14 5.0

1BTotal 122 102 21.5

Instructors of 2nd Semester Modules

Antonopoulos John J.A. Batzias Georgios G.B. Batzios Christos C.B. Botsoglou Nikolaos N.B. Christaki Efterpi Ε.C. Dinopoulos Athanasios A.D. Koutsoviti‐Papadopoulou Maria M.K. ‐ P. Lavrentiadou Sofia S.L. Nikolaidis Efstathios Ε.Ν. Paneri Panagiota P.P. Papadopoulos Georgios C. G.C.P. Sachana Magdalini M.S. Tsantarliotou Maria M.Ts.

22

23 2nd Module ‐ 2nd Semester

Structure and Function of Body Systems Ι

Learning objectives At the end of these courses, students should be able to: 1. Understand the origins and classification of drugs and their receptors, the purposes of drug therapy, and cellular processes acted upon by the commonly used drugs. 2. Outline the development and main anatomical features of the nervous system and environment of the CNS. 3. Understand the structure, metabolism and function of the peripheral and central nervous systems and how these functions can me modified by anesthetics, analgesics and sedatives. 4. Understand the principles of control of Body Systems by nerves and hormones as well as by intrinsic mechanisms to homeostasis and movement, including knowledge of the structure of Locomotor and Endocrine System. 5. Understand the mechanisms of adaptation to different environments, including responses to stress and thermoregulation.

1st Section

139BA. General Pharmacology 1st‐2nd hour Introduction, scope and role of veterinary pharmacology, sourses of the drugs, nomenclature of the drugs [G.B.] 3rd hour Routes of administration [G.B.] 4th hour Pharmacodynamics [G.B.] 5th‐8th hour Pharmacokinetics [G.B.] 9th‐10th hour Side effects of the drugs, interactions with other drugs, the factors which influence the activity of the drugs, withdrawal periods of the drugs, discovery and development of drugs [G.B.]

140BΒ. The nervous system‐Neurohumoral control 11th hour Introduction [G.C.P.] 12th‐15th hour Organization principles of the nervous tissue (nerve cells, glial cells, receptors, gray and white matter, nerves, ganglia, meninges, blood brain barrier [G.C.P.]

24 16th‐18th hour Functional principles of the nervous tissue (nerve impulse, neural communication, neurotransmitters, postsynaptic receptors, neuromuscular synapses, motor end plate) [M.Ts.] 19th‐20th hour Energy metabolism in nervous tissue [M.S.] 21st‐22nd hour Development of the nervous tissue, main parts of the CNS‐ functional specialization [G.C.P.] 2 hours Nervous tissue, nerves, ganglia, motor and sensory nerve endings (Histology) 23rd‐26th hour Organization of the spinal cord [G.C.P.] 27th hour Spinal reflexes [M.Ts.] 28th‐29th hour Organization of the brainstem and the cerebellum [G.C.P.] 30th hour Physiological role of the brainstem and the cerebellum [M.Ts.] 2 hours Brainstem and cerebellum (Gross Anatomy) 31st‐32nd hour Cerebral hemispheres and hypothalamus [G.C.P.] 2 hours Cerebral hemispheres, cerebral commisures, ventricles of the brain (Gross Anatomy) 2 hours Spinal cord, meninges of the CNS (Gross Anatomy) 33rd hour The neural control of sleep and waking [M.Ts.] 2 hours Spinal cord, cerebellum, cerebral cortex (Histology)

2nd Section 34th‐37th hour Structural organization of the ANS [Α.D.] 38th‐39th hour Physiological role of ANS [M.Ts.] 3 hours Pharmaceutical Forms (Pharmacology, tutorial) 3 hours Drug administration routes (Pharmacology, in lab animals) 3 hours Drug prescription (Pharmacology, tutorial) 3 hours Pharmacodynamics (Pharmacology, experiments on isolated intestinal preparations; dose‐response curves; Emax, Emin, ED50 values; receptors; competitive and non‐ competitive antagonism) 40th‐43rd hour Drugs acting on the Autonomic Nervous System: adrenoceptor agonists (non‐selective; α‐ and β‐ adrenoceptor agonists; selective β2‐adrenoceptor agonists); Adrenoceptor blocking drugs (α‐ and β‐ adrenoceptor blocking drugs; Selective β1‐adrenoceptor blocking drugs); Cholinergic pharmacology: cholinoceptor‐ activating drugs; cholinesterase‐inhibiting drugs; antimuscarinic drugs; autonomic ganglion blocking drugs [M.K.‐P.] 44th hour Muscle relaxants: neuromuscular blocking drugs (depolarizing‐non‐depolarizing blocking drugs); centrally acting muscle relaxants [M.K.‐P.] 45th‐46 th hour CNS stimulants; Analeptics [M.K.‐P.]

25 141BC. Sensory organs, the main sensory and motor neural pathways, pain, anaesthesia and analgesia 47th‐53rd hour Sensory organs: The integument and its structure, hairs, tori and pads, horn, hoof, nails. The eye and the ear [Α.D.] 54th‐56th hour Somatosensory pathways (touch, pressure, pain, temperature). Visual pathways. Vestibular pathways, Auditory pathways. Taste and smell [G.C.P.] 57th‐58th hour Thermoregulation [S.L.] 59th hour Energy metabolism in the eye [M.S.] 60th‐61st hour Visual activity, receptors and neural function of the retina, physiology of hearing and equilibrium, sensory receptors of the inner ear and their function [S.L.] 62nd hour Physiology of pain perception, reffered pain, hyperalgesia, opioids [M.Ts.] 2 hours The eye (Gross Anatomy) 2 hours The ear and the hoof (Gross Anatomy) 2 hours The fine structure of the integument and the retina (Histology) 63rd‐64th hour Motor pathways (pyramidal and extrapyramidal) [G.C.P.] 65th hour Introduction to the PNS, cranial nerves (general) [Α.D.] 66th hour Olfactory nerves, optic nerve, oculomotor nerve, trochlear nerve, trigeminal nerve [Α.D.] 67th hour The abducent nerve, facial nerve, vestibulocochlear nerve, glossopharyngeal nerve [Α.D.] 68th hour The vagus nerve, accessory nerve, hypoglossal nerve [Α.D.] 2 hours The cranial nerves (Gross Anatomy) 69th hour Spinal nerves (introduction), cervical nerves, thoracic nerves, lumbar nerves. The brachial plexus, the lumbosacral plexus [Α.D.] 2 hours The brachial and the lumbosacral plexuses (Gross Anatomy) 70th‐73rd hour Local anesthetics, General anesthetics (inhalational and intravenous anesthetics) pro anesthesia drugs [Ε.Ν.] 74th‐75th hour Tranquilisers, sedatives, hypnotics, antiepileptics and analgesics [E.N.]

3rd Section

142BD. Endocrine glands ‐ Hormones 76th hour Hormones: what they are, functions and types; control of production, release and transportation of hormones. Methods for demonstrating hormone concentration [M.Ts.] 77th hour Hypophysis or Pituitary gland: topography, embryologic origin and development, fine structure, blood vessels and nerves [J.A.]

26 78th hour Hypothalamic control of pituitary gland secretion, the physiological role of growth hormone and somatomedins (IGFs) as well [M.Ts.] 79th hour Control of growth hormone release and disorders. Antidiuretic hormone (ADH): mechanism of action, control of secretion. Oxytocin: mechanism of action, control of secretion [M.Ts.] 80th hour Pancreatic islets: fine structure [J.A.] 2 hours Hypophysis, pancreatic islets (Histology) 81st hour Hormones of pancreatic islets: insulin, glucagons, somatostatin, pancreatic polypeptide: mechanism of action, control of secretion [M.Ts.] 3 hours Hormonal regulation of rat blood glucose (Physiololgy) 82nd hour Thyroid gland, parathyroid glands: topography, embryonic origin and development, fine structure, blood vessels and nerves [J.A.] 83rd hour Synthesis, release and transportation of thyroid hormones, mechanism of action [M.Ts.] 84th hour Control of thyroid hormone secretion, hyperthyroidism, hypothyroidism. Regulation of the extracellular calcium concentration: parathyroid hormone, calcitonin, vitamin D: mechanisms of action [M.Ts.] 85th hour Control of secretion of parathyroid hormone, calcitonin, vitamin D. Hypoparathyroid, hyperparathyroid, rickets [M.Ts.] 86th hour Adrenal glands, pineal gland: topography, embryonic origin and development, fine structure, blood vessels and nerves [J.A.] 87th hour Aldosterone: mechanism of action, control of secretion. Cortisol: mechanism of action, control of secretion. Secretion abnormalities of the adrenal cortex [M.Ts.] 88th hour Stress. Melatonin, mechanism of action [M.Ts.] 89th hour The physiological role of leptin. The hormones of the endocrine system that are involved in controlling the rate and direction of metabolism. Biological circadian rhythms [M.Ts.]

2 hours Adrenal glands, thyroid gland, parathyroid glands (Histology) 90th hour Antidiabetic drugs, glucose elevating drugs, thyroid drugs (thyroid hormones, antithyroid drugs) [E.N.]

143BE. Locomotor System 9Χ2 hours Osteology (Gross Anatomy) 3Χ2 hours Syndesmology (Gross Anatomy) 3Χ4 hours Myology in animal cadavers (Gross Anatomy)

27 90th‐93rd hour Skeletal muscles: muscle mechanics and performance, myogram, the “all‐or‐none” principle, motor unit, wave summation, tetanus, isotonic and isometric contractions “fast” and “slow” fibers, fatigue, muscle hypertrophy and atrophy, trophic effect of motor neurons on muscle cells [S.L.] 2 hours Principles of physiograph operation and other laboratory equipment (Physiology) 3 hours Frog nerve ‐ muscle preparation (wave summation, tetanus etc. in the gastrocnemius muscle of the frog) (Physiology)

Grade Distribution of Practical Examination Anatomy(macroscopic and microscopic) 70% Pharmacology 20% Physiology 10%

Final Grade Theory 70% Practicals 30%

28 th nd 4 (II) Module ‐ 2 Semester

Animal Science II

Learning objectives 1. Introduction to animal nutrition and bromatology. 2. Types of feeds and feedstuffs. 3. Various feed nutrients (carbohydrates, lipids, proteins). 4. Composition of feeds / feedstuffs and animal body. 5. Energy value of nutrients and feedstuffs and animal body energy expenses and requirements for maintenance and production. 6. Types of feedd energy an methods of evaluation. 7. Proximate analysis of feedstuffs according to the Weende and other systems / or methods. 8. Familiarisation with basic concepts in animal production economics. 9. Knowledge of production theory and theory of cost. 10. Understanding the use and organization of production factors in animal production establishments (capital, land, labor). 11. Realizing of the peculiarities of prime costs forming of animal products and cost‐profit relationships 12. Knowledge of planning and budgeting of agribusiness. 13. In‐depth knowledge of aspects regarding the control of agribusiness (compilation of balance sheet, income statement, ratios analysis). 14. Understanding the long‐term investment projects evaluation in agribusiness 15. Understanding the basic principles of the Common Agricultural Policy (CAP) for animal products.

1st Section

144BA. Fundamentals of Animal Nutrition 1st hour Introduction to animal nutrition and bromatology [E.C.] 2nd hour Types of feeds and feedstuffs [E.C.] 3rd hour Feed nutrients [N.B.] 4th hour Carbohydrates [N.B.] 5th hour Lipids [N.B.] 6th hour Proteins [P.P.] 7th hour Composition of feeds/feedstuffs and animal body [N.B.] 8th hour Energy value of nutrients and feedstuffs [E.C.] 9th hour Energy requirements of animals [P.P.] 10th hour Types of feed energy and methods of evaluation [P.P.]

Practicals 8 hours Proximate analysis of feeds/feedstuff [N.B., P.P., E.C.]

29 2nd Section

145BB. Animal Production Economics 11th‐12th hour Introductory concepts in animal production economics. The basic measures of an economy (GDP, GNI, NI, etc.), the concept of added value, investments and capital formation, constant and current prices of economic variables, price indices. Measuring inequality (Lorenz curves, Gini coefficient) [C.B.] 13rd hour The farm structure in Greece per sector (pigs, cattle, sheep and goats, etc.) [C.B.] 14th‐16th hour Theory of production (the production function of animal products, the stages of production, the elasticity of production, the factor‐product and the factor‐factor relationship, substitution of production factors) [C.B.] 17th‐18th hour The theory of cost (cost and its basic principles, identification of costs, economies of scale, short‐run and long‐ run cost of production, economies of scale, maximizing profit in agribusiness) [C.B.] 19th‐20th hour Calculus of cost in animal production utilization (approaching the cost of mechanical equipment, cost of building and infrastructure, labor cost, methods of depreciation) [C.B.] 21st hour Planning and Budgeting of farms (whole farm budget, partial budget, break even budget, cash flow budget) [C.B.] 22nd‐24th hour Capital and its use (the use of capital, the principle of increasing risk, cost of borrowing and methods, time value of money (present and future value), types of loans, methods of loans repayment) [C.B.] 25th hour Control of the agribusiness (the Balance Sheet, the Income Statement, ratio analysis) [C.B.] 26th hour Investment Analysis (types of investment, methods of evaluating investment plans) [C.B.] 27th hour Principles of the Common Agricultural Policy (CAP), Animal production and CAP [C.B.] 28th hour Concept of comparative advantage, animal production and uncertainty, use of credit in agribusiness [C.B.]

Practicals 3 hours Calculus of depreciation, use of methods of loans repayment, compiling of budgets (whole farm budget, partial budget, break even budget, cash flow budget) [C.B.] 3 hours Compiling and analyses of Income Statements dan Balance Sheets. Investment projects evaluation of different types of farms [C.B.]

30

MODULE 3rd Semester Hours/semester

85BL P ECTS

Animal Science ΙΙΙ (including Pig Production, Poultry 4th (ΙΙΙ) Production and Equine Husbundry, Pet Husbandry, 57 55 10.5 Rabbit Production and Husbandry of Laboratory Animals)

Structure and Function of Body Systems II (including 5th (Ι) the Anatomy, Physiology, Biochemistry, and 99 83 16.5 Pharmacology of the Circulatory, Respiratory, Urinary, Reproductive System and the Udder)

31BTotal 156 138 27.0

Instructors of 3rd Semester Modules

Antonopoulos John J.A. Arsenos George G.Α. Banos George G.B. Batzios Christos C.B. Christaki Efterpi Ε.C. Dori Ioanna I.D. Fortomaris Paschalis P.F. Karamanlis Xanthipos X.Κ. Koutsoviti‐Papadopoulou Maria M.K. ‐ P. Lavrentiadou Sofia S.L. Michaloudi Eleni E.M. Nikolaidis Efstathios E.N. Paneri Panagiota P.P. Sachana Magdalini M.S. Stamataris Constantinos C.S. Taitzoglou Ioannis A. I.A.T. Tsantarliotou Maria M.Ts. Tserveni‐Gousi Angeliki A.T. ‐ G Tsingotjidou Anastasia A.Ts.

31 Valergakis George G.V. Zervos Ioannis A. Ι.Α.Ζ.

4th (III) Module ‐ 3rd Semester

Animal Science III Learning objectives

1. In‐depth knowledge of all aspects of breeding/raising swine, poultry, equines rabbits and laboratory animals. 2. Ability to critically evaluate and analyse pertinent on‐farm issues and provide advice to the farmer. 3. Ability to recognise common animal breeds within different farm animal species as well as companion animals. 4. Knowledge of adequate nutrition and normal eating pattern differences by life stage and animal state as well as ability to design appropriate nutritional programs. 5. Ability to assist farmers in designing appropriate housing facilities based upon space requirements and best known welfare practices for different species.

1st Section

146BA. Animal husbandry ‐ Pig production 1st‐2nd hour Structure and significance of Pig Production. Pig Production in Greece and worldwide. Current situation, problems and trends. Classification, origin and nomenclature of pigs [P.F.] 3rd hour Conformation of pigs and its assessment [P.F.] 4th‐5th hours Production qualities of pigs and their expression: Reproduction [P.F.] 6th‐7th hours Production qualities of pigs and their expression: Meat production [P.F.] 8th hour Pig breeds [P.F.] 9th‐10th hour Evaluation of the productive ability of pigs. Genetic improvement of pigs. Selection. Breeding methods [G.B.] 11th‐12th hour Pig rearing (Boars, sows and piglets. Fattening) [P.F., P.P.] 13th‐16th hour Pig housing. General principles of construction, barn types, hygiene. Behaviour, welfare and health management of pigs. Handling of pigs during transport. Protection of the environment [P.F., X.K.] 17th hour Pig farm organization. Pig meat production cost [P.F., C.B.]

32 2nd Section

147BB. Animal husbandry ‐ Poultry production 18th‐19th hour Structure and significance of Poultry Production. Poultry Production in Greece and worldwide. Current situation, problems and trends. Classification, origin, domestication and nomenclature of poultry. Conformation of poultry [A.T.‐ G] 20th hour Breeds of hens [A.T.‐ G] 21st‐22nd hour Production qualities of hens and their expression. I. Egg production (characteristics, factors affecting it, assessment parameters, egg quality) [A.T.‐ G] 23rd‐24th hour II. Reproduction [A.T.‐ G] 25th‐26th hour III. Meat production [A.T.‐ G] 27th hour Genetic improvements of hens [P.F.] 28th‐29th hour Poultry housing facilities. General principles of construction, barn types. Hygiene. Protection of the environment [A.T.‐ G, X.K] 30th‐33nd hour Rearing of broilers, hens and broilers. (Animal stock, housing, micro‐climate, nutrition, beak‐trimming, handling, replacement of the broilers) [A.T.‐G, E.C.] 34rd‐35th hour Behaviour, welfare and health management of poultry. Handling of poultry during transportation [A.T.‐ G]

3rd Section

148BC. Animal husbandry – Equine husbandry, pets, rabbit farming and laboratory animals 36th hour Origin, significance, species, types and nomenclature of equines. Economic importance of equines [G.A.] 37th hour Body conformation and judging of equines [G.A.] 38th‐39th hour Colours markings and special characteristics of equines. breeds of major importance [G.A.] 40th‐41st hour Rearing methods and management. Principles of training and use of riding equines. Equine housing facilities. Hygiene [G.A.] 42nd hour Behaviour and welfare of horses. Handling of horses during transportation [G.A.] 43rd‐45th hour Origin, classification, nomenclature, external morphological characteristics, breeds of dog [A.T.‐G] 46th‐48th hour Dog breeds, reproduction, rearing, behaviour and welfare of dog. Dog training [A.T.‐G] 49th‐50th hour Origin, classification, nomenclature, external morphological characteristics, breeds, reproduction, welfare and training of cats [A.T.‐G] 51st‐52nd hour Origin, classification, nomenclature, main external morphological characteristics and breeds of rabbits [P.F.] 53rd hour Production qualities of rabbits and their expression: I. Reproduction, II. Meat production, III. Hair production [P.F.]

33 54th hour Rabbit farming methods, housing, hygiene, behaviour and welfare of rabbits. Preventive hygiene. Handling of rabbits during transportation [P.F.] 55th‐57th hour General principles for laboratory animals production ‐ welfare of laboratory animals [P.F.]

Practicals 6 hours Demonstration of the pig housing facilities of pig farms, layout and equipment of specialized barns. Age and genotype identification [P.F., G.A., C.S., G.V., G.B., A.T.‐G, P.P.] 6 hours Demonstration of the pig rearing systems and methods. Evaluation of the body formation in relation to age, sex, genotype and rearing method [P.F., G.A., C.S., G.V., G.B., A.T.‐ G] 6 hours Evaluation of pig carcasses in relation to the farming method. Identification of potential problems in the pig farming and estimation of their effects on the health and welfare of the farmed animals. Suggested solutions [P.F., G.A., C.S., G.V., G.B., A.T.‐ G] 6 hours Demonstration of the hen housing facilities of poultry farms, layout and equipment of specialized barns for broilers. Evaluation of poultry carcass. Identification of potential problems in the poultry farming and estimation of their effects on the health and welfare of the farmed animals. Suggested solutions [A.T.‐G, P.F., G.A., C.S., G.V., G.B.] 6 hours Demonstration of the hen housing facilities of poultry farms, layout and equipment of specialized barns for hens. Evaluation of quality of the eggs. Identification of potential problems in the poultry farming and estimation of their effects on the health and welfare of the farmed animals. Suggested solutions [P.F., G.A., C.S., G.V., G.B., A.T.‐ G] 6 hours Demonstration of the hen housing facilities of poultry farms, layout and equipment of specialized barns for the breeders. Identification of potential problems in the poultry farming and estimation of their effects on the health and welfare of the farmed animals. Suggested solutions [E.C., A.T.‐ G, P.F., G.A., C.S., G.V., G.B.] 3 hours Approaching and handling of horses. Identification of breeds, coloration and special characteristics of equine [G.A., P.F., C.S., G.V., G.B., A.T.‐ G] 3 hours Assessment of age of horses in the laboratory [G.A., P.F., C.S., G.V., G.B., A.T.‐G] 4 hours Identification of dog breeds. Approaching, constrain and training of dogs [P.F., A.G., C.S., G.V., G.B., A.T.‐ G]

34 6 hours Demonstration of rabbit housing facilities. Demonstration of the rabbit farming systems and methods. Identification of age and breed or the mixed‐breed type [P.F., G.A., C.S., G.V., G.B., A.T.‐ G] 3 hours Demonstration of the layout and equipment of the specialised cells for laboratory animals. Identification of species, breed or mixed‐breed type [P.F., G.A., C.S., G.V., G.B., A.T.‐ G]

5th (I) Module ‐ 3rd Semester

Structure and Function of Body Systems II th 2B5 (I) course ‐ Structure and Function of Body Systems II

Learning objectives This module, which is a continuation of module 2 (Structure and Function Body Systems I), covers the anatomy, biochemistry, physiology and pharmacology of the cardiovascular system, the blood and haemopoietic tissues, the respiratory system, the urinary system and the reproductive system. Learning objectives of the present module include: Cardiovascular system: to understand the structure of the cardiovascular system, the physiology of the cardiac function, as well as the effects of drugs on the heart and their use in treating cardiac diseases; to understand the structure and control of vascular smooth muscle and to consider clinical uses of vasoactive drugs in several diseases. Blood and haemopoietic tissues: to understand the structure of the haemopoietic tissues and blood elements as well as the main features of blood coagulation, platelet function and fibrinolysis as a basis for understanding haemorrhagic disorders and thrombotic diseases; tor conside drugs acting on the coagulation cascade and on the platelets; to consider the haematinic drugs used to treat the different kinds of anaemia. Respiratory system: to understand the structure and function of the respiratory system as a prelude to pulmonary diseases, and drugs used in their treatments. Urinary system: to understand the renal structure and function, the acid‐balance disorders, and to consider the use of diuretics in several diseases. Reproductive system: to understand the structure and function of the male and female reproductive systems and how their functioning can be modified for superovulation, oestrous cycle control and artificial insemination.

1st Section

149BΑ. Cardiovascular System 1st‐2nd hour Heart: topography, anatomy overview of the heart, compartments and blood vessels, cardiac vessels and nerves, pericardium [J.A.]

35 3rd hour Arteries: an overview, arteries of the pulmonary circulation, arteries of the systemic circulation, differences between animals [J.A.] 4th hour Veins: an overview, veins of the pulmonary circulation, veins of the systemic circulation, veins for blood draw [J.A.] 5th hour Lymphatic system: lymph vessels, lymph nodes, lymph centers [J.A.] 6th hour Embryonic origin and development of the cardiovascular system, placental circulation, pulmonary and systemic circulations [J.A.] 7th hour Fine structure of the heart [J.A.] 8th hour Fine structure of the blood vessels, capillaries [J.A.] 2 hours Vessels (arteries‐veins) (Histology) 2 hours Heart ‐ pericardium (Gross anatomy) 2 hours Arteries of the head (Gross anatomy) 2 hours Arteries of the body, arteries of the thoracic and pelvic limbs (Gross anatomy) 9th hour Cardiac muscle: Properties of the cardiac muscle cells, action potentials. Effect of the autonomic nervous system and inorganic ions on the cardiac function [I.A.T.] 10th hour The specialized cardiac muscle cells that initiate and organize each heartbeat. The specialized conducting system of the heart [I.A.T.] 11th hour The electrocardiogram: Standardized electrocardiographic leads, electrical dysfunctions of the heart [I.A.T.] 3 hours ECG (rabbit) (Physiology) 12th hour The heart as a pump, cardiac cycle, stroke volume, ejection fraction [I.A.T.] 13th hour Cardiac output, end‐diastolic volume, end‐systolic volume. Starling’s law of the heart, cardiac sounds, cardiac murmurs. The pathologic consequences of cardiac defects result in abnormal pressures, volumes and workloads in cardiac chambers [I.A.T.] 14th hour The systemic and pulmonary circulations. Arterial blood pressure, vascular resistance, Poiseuille’s law, blood flow in organs [I.A.T.] 15th hour Systolic‐diastolic‐pulse pressure [I.A.T.] 16th hour Capillaries and fluid exchange. Fick’s law of diffusion. The Starling equation, the lymphatic system, edema [I.A.T.] 17th hour Local control of blood flow [I.A.T.] 3 hours Cardiomyogram (frog) (Physiology) 18th hour Neural and hormonal control of blood pressure and blood volume [I.A.T.] 19th hour Integrated cardiovascular responses [I.A.T.] 20th hour Energy metabolism in the cardiac muscle [Μ.S.]

36 150BB. Blood ‐ Haemopoietic tissues 21st‐22nd hour Blood: plasma, blood cells. Erythrocytes, leucocytes (neutrophils, eosinophils, basophils, lymphocytes, monocytes), platelets [I.D.] 23rd hour Haemopoietic tissues. Fine structure of myeloid tissue (bone marrow). Development of erythrocytes, granulocytes, agranulocytes, platelets [I.D.] 24th hour Fine structure of lymphoid tissue. Lymph nodes, lymphatic nodules (tonsils). [I.D.] 25th‐26th hour Fine structure of thymus. Fine structure of spleen. [I.D.] 2 hours Blood (Histology) 2 hours Lymph nodes, spleen, thymus (Histology) 3 hours Red blood cell count (Physiology) 3 hours White blood cell count (Physiology) 27th‐28th hour Blood composition and functions, Plasma and its proteins, Red blood cells: structure and function, hemoglobin, metabolism, blood groups [S.L.] 3 hours Differential white blood cell count (Physiology) 3 hours Hematocrit, Erythrocyte sedimentation rate, Hemoglobin content determination (Physiology) 29th‐30th hour Erythropoiesis and erythropoietin, Anemias, White blood cells: WBC production, differential WBC count, Platelets [S.L.] 31st hour Hemostasis‐Fibrinolysis [S.L.] 3 hours Blood group determination. Red blood cell resistance (Physiology)

2nd Section

151BC. Respiratory System 32nd hour Upper respiratory tract: nose, larynx, trachea [J.A.] 33rd hour Thoracic cavity‐pleura. Lung: topography, lobes of the lung, differences between animals [J.A.] 2 hours Organs of the respiratory system (Gross anatomy) 34th hour Embryonic origin and development of the respiratory system. Fine structure of the nose, larynx, trachea [J.A.] 35th hour Fine structure of the lung [J.A.] 2 hours Trachea, lung (Histology) 36th hour Pulmonary ventilation and pulmonary circulation. Changes of pleural and alveolar pressures. Lung compliance. Pulmonary volumes and capacities. The effect of dead space on alveolar ventilation [I.A.T.] 3 hours Recording changes in pulmonary volume [in humans] (Physiology, lab. exercise) 37th hour Airway, lung tissue and chest wall resistance. Composition of inspired, expired and alveolar air (relation to atmospheric air). Normal ventilation, hyperventilation, hypoventilation. Blood flow changes and blood

37 distribution through the different parts of the lungs during ventilation [I.A.T.] 38th hour Diffusion of gases through the respiratory membrane. Transport of oxygen and carbon dioxide in blood and body fluids. The respiratory quotient [I.A.T.] 39th hour Respiratory regulation and rhythm (chemical and mechanical factors affecting respiration). Periodic breathing. Respiratory insufficiency (pulmonary emphysema, pneumonia, asthma, tuberculosis, pulmonary edema) [I.A.T.] 3 hours Action of several drugs on the respiratory system (Pharmacology, lab animals)

152BD. Urinary System 40th hour Kidneys: position, relationships, shape. Renal pelvis, ureter, urinary bladder, urethra (female). Organogenesis [E.M.] 2 hours Urinary system (Gross anatomy) 41th hour Fine structure of kidneys [E.M.] 42th hour Fine structure of renal pelvis, ureter, urinary bladder, urethra (female) [E.M.] 2 hours Kidney, urinary bladder (Histology) 43rd hour Fluid compartments, dynamic equilibrium of body water, renal function, glomerular filtration, concept of renal clearance [M.Ts.] 44th hour Glomerular filtration rate (GFR), the renal circulation, autoregulation of GFR, and renal clearance measurements. Changes in GFR, measurement of GFR, inulin, creatinin, the effects of renal pathology [M.Ts.] 45th hour Tubular reabsorption and secretion. Types of mechanisms: active, passive [M.Ts.] 46th hour The countercurrent mechanism for the concentration and dilution of the urine, control of water permeability of collecting ducts by ADH. ADH action on cells, the role of aldosterone, urea reabsorption, renal control of body calcium and phosphate [M.Ts.] 47th hour Blood pH and [H+]. Buffers‐bicarbonate, phosphate, proteins, respiratory control of acid‐base balance, and renal control of H+ concentration [M.Ts.] 48th hour Acid‐base balance disorders, micturition reflex, role of spinal cord and brain stem, micturition disorders [M.Ts.] 49th hour Energy metabolism in the kidneys [Μ.S.]

153BE. Drugs acting to: a. urinary, b. circulatory, c. respiratory system 50th hour Drugs used for the management of fluid and electrolytes’ balance [M.K.‐P.]

38 51th‐52th hour Diuretics: osmotic diuretics; methylxanthines; carbonic anhydrase inhibitors; loop diuretics; thiazides; aldosterone inhibitors; potassium‐retaining diuretics [M.K.‐P.] 53th‐54th hour Agents used in cardiac arrhythmias: sodium channel blockers; β‐adrenoceptor blocking drugs; agents that prolong action potential duration; calcium channel blockers; other antiarrhythmics [M.K.‐P.] 55th‐56th hour Drugs used in heart failure: inotropic agents; digitalis glycosides; bipyridine derivatives; sympathomimetics; methylxanthines; Antianginal drugs [M.K.‐P.] 57th hour Vasodilators: arterio‐dilators; veno‐dilators; arterio‐ venodilators (organic nitrates; calcium channel blockers; ACE inhibitors; α‐adrenoceptor blocking drugs); Antihypertensive drugs [M.K.‐P.] 58th hour Drugs acting on the blood: anticoagulants; antiplatelet drugs; thrombolytics; antihemorrhagic agents [M.K.‐P.] 59th hour Antianaemic drugs: Drugs administered in iron‐deficiency, in megaloblastic and in aplastic anaemias [M.K.‐P.] 60th‐61th hour Drugs acting on the respiratory system: expectorants; mucolytics; bronchodilators; histamine, antihistamines and allergies; mast‐cell stabilizers; drugs used for the management of asthma; antitussives; respiratory stimulants [M.K.‐P.] 3 hours Pharmacodynamic studies (mechanism of action, actions and interactions) of several drugs on the isolated heart (Pharmacology, lab animals) 3 hours Agonists and antagonists: Computer simulation (Pharmacology) 3 hours General anesthesia (Pharmacology, lab animals)

3rd Section

154BF. Reproductive System ‐ Udder 62nd hour Formation of male reproductive system in domestic mammals. Testes, general anatomical overview, descent of the testes, position and relationships in domestic mammals. Sheaths of the testes, macroscopic description of testes [A.Ts.] 63th hour Microscopic description of testis: tunica albuginea, seminiferous tubules, interstitial tissue [Α.Τs.] 64th hour Spermatogenesis, spermiogenesis, fine structure of spermatozoa [Α.Τs.] 65th hour Epididymis: macroscopic description, position and relationships in domestic mammals, microscopic description. Vas deferens: macroscopic description, route and relevance in domestic mammals, microscopic description [Α.Τs.]

39 2 hours Testes, epididymis (Gross anatomy) 2 hours Testis, epididymis, spermatozoa (Histology) 66th hour Accessory genital glands (seminal vescicles, prostate gland, bolbourethral glands): macroscopic description, differences, position and relationships in domestic mammals, microscopic description. Male urethra (pelvic and spongy part): macroscopic description, route and relationships in domestic mammals, microscopic description [Α.Τs.] 67th hour Penis (crus penis, urethral body, glans, prepuce): macroscopic description, route and relationships in domestic mammals, microscopic description. Blood vessels and nerves of male reproductive system [Α.Τs.] 68th hour Penis: macroscopic description [Α.Τs.] 2 hours Vas deferens, accessory genital glands, penis (Gross anatomy) 69th hour Introduction, androgens (biosynthesis, site of production, catabolism, regulation of production, physiologic role) [Ι.Α.Ζ.] 70th hour Spermatozoa: site and process of spermatogenesis, maturation, storage, degeneration and absorption [Ι.Α.Ζ.] 71th hour Humoral control and factors that affect spermatogenesis [Ι.Α.Ζ.] 3 hours Sperm I (Physiology) 72th hour Epididymis, vas deferens, prostate, seminal vesicles and bulbourethral glands: the physiologic role [Ι.Α.Ζ.] 73th hour Penile erection and coitus. Ejaculation. Puberty [Ι.Α.Ζ.] 3 hours Sperm II‐castration of a rat (Physiology) 74th hour Formation of female reproductive system in domestic animals. Ovaries: general anatomical overview, macroscopic description, position and relationshps in domestic mammals [Α.Τs.] 75th hour Ovaries: microscopic description. Ovarian follicles: Primordial, primary, mature follicle, follicular atresia, corpus luteum, interstitial cells of ovary [Α.Τs.] 76th hour Oviduct: macroscopic description, route and relationships in domestic mammals, microscopic description. Uterus: macroscopic description, position and relationships in domestic mammals, microscopic description [Α.Τs.] 2 hours Ovaries and oviduct (Gross anatomy) 2 hours Ovaries, oviduct, uterus, placenta (Histology) 77th hour Broad ligaments: description, position and relationships in domestic mammals. Vagina: macroscopic description, position and relationships in domestic mammals, microscopic description. Vulva: macroscopic description, route and relationships in domestic mammals, microscopic description [Α.Τs.]

40 2 hours Uterus, vagina, vulva and udder (Gross anatomy) 78th hour Formation of extraembryonic membranes in mammals: embryogenic membranes, metrogenic membranes. Placenta: general overview, epitheliochorial, syndesmochorial, endotheliochorial and hemochorial placenta, diffuse, cotyledonary, zonary and discoid placenta, implantation or nidation of blastocyst [Α.Τs.] 79th hour Umbilical cord: umbilical arteries, umbilical veins, umbilical vesicle, allantoic diverticulum, Wharton’s jelly, feeding of the embryo in mammals [Α.Τs.] 80th hour Embryonic appendages in pig: diffuse epitheliochorial semiplacenta. Embryonic appendages in ruminants: cotyledonary epitheliochorial placenta and cotyledonary epitheliochorial placenta with parts of syndesmochorial placenta [Α.Τs.] 81th hour Embryonic appendages in equine: diffuse epitheliochorial semiplacenta. Embryonic appendages in carnivores: zonary endotheliochorial full placenta [Α.Τs.] 2 hours Umbilical cord, demonstration of embryonic membranes (Histology) 82th hour Follicles, chemical composition of the follicular fluid, oviduct, uterus, vagina, transport of spermatozoa, antibodies against spermatozoa ovulation [Ι.Α.Ζ.] 83th–84th hour Capacitation of spermatozoa, the acrosome reaction and the zona reaction [Ι.Α.Ζ.] 85th–86th hour Corpus luteum, estrogens, progesterone, androgens: their effect on the body and specifically on the female genital tract [Ι.Α.Ζ.] 87th–88th hour The hypothalamus‐pituitary gland‐ovary axis, ovariectomy, relaxin, female reproductive cycles in various animal species and in humans, photoperiodism, puberty, pheromones [Ι.Α.Ζ.] 3 hours Ovariectomy of a rat (Physiology) 89th hour Pregnancy: length of pregnancy, maternal physiology during pregnancy, estrous during pregnancy, maternal recognition of pregnancy, pregnancy diagnosis, litter size [Ι.Α.Ζ.] 90th hour Induction of parturition, first ovulation after parturition, synchronization of ovulation (estrous synchronization), use of PMSG and hCG in veterinary practice [Ι.Α.Ζ.] 91th hour Induction of superovulation and embryo transfer [Ι.Α.Ζ.] 92th hour Placenta: hormone production, gas exchange, transport of proteins, carbohydrates, lipids, water, microorganisms, drugs. Physiology of the fetal fluids [Ι.Α.Ζ.] 93th‐94th hour Anterior pituitary hormones, posterior pituitary hormones, pituitary and non‐pituitary donadotropins, sex hormones

41 (estrogens, progestins, prostaglandins, androgens, anabolic steroids) [E.N.] 95th hour Teratology: general principles, Cause of congenital malformations. Congenital malformations in birds and in ruminants: classification, examples of special veterinary interest [Α.Τs.] 96th hour Mechanisms of teratogeneses’ formation [Α.Τs.] 2 hours Demonstration of teratogeneses (Histology) 97th hour Udder: macroscopic description, position and relationship in domestic mammals, microscopic description [Α.Τs.] 2 hours Udder (Histology) 98th hour Effect of hormones on mammary gland development, initiation of lactation, production of milk in the alveoli, hormonal changes during lactation, use of hormones in enhancing or interrupting lactation, induction of lactation [Ι.Α.Ζ.] 99th hour The milk: quantity, composition, species differencies, lactose and lactose synthetase, milk lipids and their chemical composition, the colostrums [Ι.Α.Ζ.]

Grade Distribution of Practical Examination Anatomy(macroscopic and microscopic) 60% Pharmacology 0% Physiology 40%

Final Grade Theory 70% Practicals 30%

42

MODULE 4th Semester Hours/semester

86BL P ECTS Animal Science ΙV [(including Cattle and Small 4th (IV) Ruminant Production, Nutrition (feeds‐rations)] 48 62 9.5

Structure and Function of Body Systems ΙΙI (including Anatomy, Physiology, Biochemistry and Pharmacology 5th (ΙΙ) of the Digestive System. Avian Anatomy and 41 82 9.0 Physiology)

Pathogenic agents Ι (including Introductory Bacteriology, Introductory Mycology Pathogenic 6th (Ι) yeasts and fungi, Principles of Virology, Parasitology 83 48 13.5 and Parasitic Diseases I, Basic Immunology, Bee Diseases and Culture)

3BTotal 172 192 32.0

122BElective Topics 1. Breeding of turkey, quail, guinea fowl, pheasant and partridge (10 hours lectures, 8 hours practicals) 2. Breeds, nutrition, training, behaviour and welfare of dogs (12 hours lectures, 6 hours practicals) 3. Organization, management and funding of animal production establishments (12 hours lectures, 4 hours practicals) 4. Organic apiculture (10 hours lectures, 12 hours practicals)

43 Instructors of 4th Semester modules

Arsenos George G.A. Banos George G.B. Batzios Christos C.B. Botsoglou Nikolaos N.B. Bourtzi‐Hatzopoulou Elefth. Ε.B‐H. Christaki Efterpi E.C. Dovas Chrysostomos C.D. Diakou Anastasia A.D Flaskos John J.F. Fortomaris Paschalis P.F. Fridas Stavros S.F. Kamarianos Athanasios Α.Κ. Karamanlis Xanthippos X.K. Koutsoviti‐Papadopoulou Maria M.K.‐P. Κritas Spyridon S.Κ. Michaloudi Helen Ε.Μ. Paneri Panagiota P.P. Papadopoulos Elias E.P. Papazachariadou Margarita Μ.P. Papanastasopoulou Maria Μ.P. Petridou Evanthia Ε.P. Sachana Magdalini M.S. Siarkou Victoria V.S. Stamataris Konstantinos C.S. Taitzoglou Ioannis A. I.A.T. Tserveni‐Gousi Angeliki A.T.‐G. Valergakis George G.V.

44 4th (IV) Module ‐ 4th Semester

Animal Science IV Learning objectives

1. In‐depth knowledge of all aspects of breeding/raising cattle, sheep and goats. 2. Ability to critically evaluate and analyse pertinent on‐farm issues and provide advice to the farmer. 3. Ability to recognise common animal breeds 4. Knowledge of adequate nutrition and normal eating pattern differences by lifed stage an animal state as well as ability to design appropriate nutritional programs. 5. Ability to assist farmers in designing appropriate housing facilities based upon space requirements and best known welfare practices for different species. 6. Various feed nutrients (vitamins, inorganic substances including macro‐ and micro‐elements and drinking water). 7. Feed additives. 8. In vivo and in vitro methods for evaluation of feed digestion. 9. Description and conservation (by drying and ensilage) of roughage and concentrated feedstuffs of plant and/or animal origin and ecological problems. 10. Natural and artificial pastures, toxic plants and ecological problems. 11. Effects of nutrition on the quality of animal products. 12. Rules for preparation of rational rations and modes of the formulation of rations and their distribution to animals.

1st Section

155BAnimal husbandry ‐ Cattle production 1st hour Cattle production in Greece and worldwide. Current status, problems and trends [G.V.] 2nd hour Inheritance of qualitative and quantitative characteristics of cattle [G.B.] 3rd‐4th hour Genetic improvement of cattle [G.B.] 5th‐6th hour Species‐Breeds of cattle ‐ Nomenclature [G.V.] 7th hour Body morphology, udder conformation, and their assessment [G.V.] 8th‐9th hour Production traits of cattle and their expression I. Reproduction [G.V.] 10th‐11th hour II. Milk production [G.V.] 12th hour III. Beef production [G.V.] 13th hour Cattle housing facilities. General principles of construction, types, hygiene, protection of the environment [G.V., X.K.] 14th‐16th hour Rearing methods, behaviour and welfare of cattle. Dairy cows, natural and artificial rearing of calves, heifers, young

45 bulls and breeding bulls. Beef cattle. Fattening. Handling of cattle during transport. Milking equipment [G.V., G.V.] 17th hour Cattle farm organization. Milk and beef production cost [G.V., C.B.]

2nd Section

156BB. Animal husbandry‐Small ruminant production 18th‐19th hour Sheep and Goat production in Greece and worldwide. Present situation, problems and trends. Production systems (migrating and non‐migrating flocks). Classification, origin and nomenclature of sheep and goats. Conformation of sheep and goats (part and whole body conformation, body condition scoring, fat scores, colours, identification and ageing) [G.A.] 20th‐22nd hour Reproduction of sheep and goat (reproduction and factors affecting it, evaluation of reproductive ability, intensive systems for reproduction). Milk production (lactation curves, lactation period, factors affecting milk production, methods to evaluate milk production ability, milking, systems for goat/sheep milk production, milking equipment). Meat production (Pre ‐ and post lambing growth and development, factors that affecting them, evaluation of meat production ability, carcass types and carcass production methods). Wool production (origin and composition of hair/wool, characteristics of hair/wool production, types of hair/wool, factors affecting hair/wool production ability, evaluation of hair/wool production ability, shearing) [G.A.] 23rd‐25th hour Behaviour and welfare of sheep and goats (food/water selection, social behaviour, sexual behaviour, maternal behaviour, behaviour of the new‐born and factors affecting it). Handling of sheep and goats during transport [G.A.] 26th‐28th hour Sheep and goat breeds (indigenous Greek breeds and foreign breeds that have been imported to Greece, breeds of general interest), morphological and production characteristics. Significance for Greece [G.A.] 29th‐30th hour Methods of sheep and goat production [G.A.] 31st‐32nd hour Genetic improvement of sheep and goat (karyotype, qualitative and quantitative genetics, hybrids), genetic improvement of sheep and goat (aims, methods, inbreeding, P gene in goats) [G.B.] 33rd hour Sheep and goat housing facilities (general principles, specialized structures, floor types, types of sheep and goat housing facilities, hygiene and protection of the environment) [G.A., X.K.]

46 34th hour Sheep and goat farm organization. Production cost of milk and meat of sheep and goat [G.A., C.B.]

3rd Section

157BC. Feeds–Rations 35th hour Vitamins [P.P.] 36th hour Inorganic substances [E.C.] 37th‐38th hour Feed additives [P.P., N.B.] 39th hour In vivo and in vitro methods for evaluation of feed digestion [N.B.] 40th hour General principles of Bromatology [E.C.] 41th‐44th hour Roughages and concentrated feedstuffs [E.C., P.P.] 45th‐46th hour Methods of feed preservation and ecological problems [P.P., E.C., A.K.] 47th hour Natural/artificial pastures and ecological problems [P.P., A.K.] 48th hour Effects of nutrition on the quality of animal products [N.B.]

Practicals 2 hours Age determination of ruminants (in the laboratory) [G.B., G.V., G.A., P.F., C.S., A.T.‐G] 3 hours Approach and handling of cattle. Topography of body areas and parts in cattle. Assessment of body conformation. Body condition scoring and assessment of udder conformation in dairy cows. Identification of ruminant breeds [G.B., G.V., G.A., P.F., C.S., A.T.‐G] 3 hours* Approach and handling of small ruminants. Topography of body areas and parts in small ruminants. Assessment of body conformation. Body condition scoring and assessment of udder conformation in dairy sheep and goats. Identification of small ruminant breeds [G.B., G.V., G.A., P.F., C.S., A.T.‐G] 2 hours* Function of the milking equipments. Milking [G.B., G.A., P.F., C.S., G.V., A.T.‐G.] 5 hours Dairy cattle farming, visit to dairy cow farms, identifying problems, and suggesting solutions [G.B., G.A., P.F., C.S., G.V., A.T.‐G] 5 hours Beef cattle farming, visit to feedlots, identifying problems, and suggesting solutions [G.B., G.A., P.F., C.S., G.V., A.T.‐ G] 5 hours* Sheep farming, visit to sheep farms, identifying problems, and suggesting solutions [G.B., G.A., P.F., C.S., G.V., A.T.‐ G] 5 hours Goat farming, visit to goat farms, identifying problems, and suggesting solutions [G.B., G.A., P.F., C.S., G.V., A.T.‐ G]

47 2 hours Assessment of body conformation in ruminants [G.B., G.A., P.F., C.S., G.V., A.T.‐G] 2 hours* Assessment of body conformation in ruminants [G.B., G.A., P.F., C.S., G.V., A.T.‐G] 2 hours Toxic plants in Greek rangelands [P.P., E.C.] 6 hours Identification of various roughages [P.P., E.C., N.B.] 3 hours Identification of various concentrated feeds and natural and synthetic raw materials [P.P., E.C., N.B.] 6 hour Understanding the basic structure and the operation of compound animal‐feed production companies [P.P., E.C., N.B.] 3 hours Ensilage of feedstuffs [P.P., E.C., N.B.] 2 hours Formulation of basic ration for ruminants [P.P., E.C.] 2 hours Formulation of supplementary ration for ruminants [P.P., E.C.] 2 hours Ration formulation for poultry [P.P., E.C.] 2 hours Ration formulation for pigs [P.P., E.C.]

*The practical exercises take place in the Farm of the School in Kolchiko

48

5th (II) Module ‐ 4th Semester

Structure and Function of Body Systems ΙΙI

Aims

• To provide fundamental information on the structure/function relationships and metabolic and regulatory mechanisms controlling the function of Digestive System and its accessory organs in mammals. Also, to provide fundamental information on the Avian Anatomy and Physiology and the differences in anatomical and physiological relationships between mammals and birds

Learning Outcomes

• Understand the basic stages in the embryology of gastrointestinal tracts • Understand the anatomy and function of gastrointestinal tracts and their associated organs • Understand the extrinsic and intrinsic regulation of gastrointestinal function, including adaptation to nutritional, evolutionary and ecological factors • Understand the basic anatomical and physiological relationships between mammals and birds

Section

158BA. Digestive System 1st hour General characteristics of digestive system. Organogenesis. Abdominal cavity, abdominal regions. Pelvic cavity. Peritoneum [E.M.] 2nd hour Mouth: Oral cavity and its walls, lips, hard palate, soft palate. Pharynx [E.M.] 3rd hour Tongue: Morphology, position, relationships. Blood supply andinnervation. Fine structure. Organogenesis [E.M.] 4th hour Teeth: Morphology, categorization according to their use, function, different development. Dental formulae of all examined domestic animals. Gums. Periodontal ligament or membrane [E.M.] 5th hour Fine structure of teeth. Organogenesis [E.M.] 6th hour Esophagus: Morphology, position, relationships. Fine structure of esophagus [E.M.] 2 hours Mouth and esophagus (Gross anatomy) 2 hours Tongue, esophagus (Histology) 7th hour Stomach: simple stomachs (dog, cat), simple composite stomachs (horse, pig). Morphology, position, relationships.

49 Fine structure of the stomach wall. Blood supply. Innervation. Organogenesis [E.M.] 8th hour Complex stomach (ruminants). Morphology, position, relationships of Rumen, Reticulum, Omasum and Abomasum. Fine structure of the complex stomach wall. Blood supply. Innervation. Embryonic and foetal development. Organogenesis [E.M.] 2 hours Abdominal cavity, stomach (simple, simple composite, complex) (Gross anatomy) 2 hours Stomach (simple, simple composite, complex) (Histology) 9th hour Small intestine (duodenum, jejunum, ileum): Morphology, position, relationships. Fine structure of the small intestine wall. Blood supply. Innervation. Organogenesis [E.M.] 10th hour Large intestine (cecum, colon, rectum, anal canal): Morphology, position, relationships. Fine structure of the large intestine wall. Blood supply. Innervation. Organogenesis [E.M.] 2 hours Small and large intestine (Gross anatomy) 2 hours Small and large intestine (Histology) 11th hour Salivary glands: Morphology, position, relationships. Fine structure. Blood supply. Innervation. Organogenesis [E.M.] 12th hour Pancreas: Morphology, position, relationships. Fine structure. Blood supply. Innervation. Organogenesis [E.M.] 13th‐14th hour Liver: Morphology, position, relationships. Fine structure. Blood supply. Innervation. Organogenesis. Spleen: Morphology, position, relationships [E.M.] 2 hours Liver, pancreas, spleen (Gross anatomy) 2 hours Salivary glands, pancreas, liver (Histology) 15th hour Regulation of gastrointestinal function. Prehension and mastication of food [I.A.T.] 16th hour Deglutition. Smooth muscle activity [I.A.T.] 17th hour The enteric nervous system. Segmentation and peristalsis. Motility of the esophagus. Storage of food in stomach [I.A.T.] 18th hour Control of gastric motility. Gastric emptying. Vomiting [I.A.T.] 19th hour The microbial ecosystem of fermentative digestion. Substrates of fermentative digestion. Reticulorumen motility. Rumination [I.A.T.] 20th hour Control of reticulorumen motility. Omasal function. Rumen development and esophageal function [I.A.T.] 21st hour Motility of the small intestine. The ileocecal sphincter. Motility of the colon in the dog and cat [I.A.T.] 22nd hour Function of the equine large hindgut. Defecation [I.A.T.] 23rd hour The salivary glands. The gastric secretion [I.A.T.] 24th hour Pancreatic exocrine secretions [I.A.T.] 25th hour Bile secretion [I.A.T.]

50 26th hour Intestinal secretion. Gastrointestinal blood flow [I.A.T.] 27th hour Digestion and absorption: The nonfermentative processes [I.A.T.] 28th hour Digestion: The fermentative processes [I.A.T.] 1.5 hours The digestive system: A basic look (Physiology) 1.5 hours The ruminants’digestive system (Physiology) 29th hour Biochemistry of intestine epithelial cells. Transport of substances and energy metabolism in the gut [Μ.S.] 30th hour The role of volatile fatty acids in ruminant metabolism. Glucose in ruminants. Ruminant gluconeogenesis [Μ.S.] 31th hour Fatty acids in the rumen. Ruminant fatty acids synthesis in adipose tissue and mammary gland [M.S.] 32th‐33th hour Drugs used to inhibit or neutralize gastric acid secretion: antacids; acid secretion reducers (H2‐receptor antagonists; proton‐pump inhibitors); enhancing mucosal resistance drugs [Μ.Κ‐P.] 34th hour Drugs acting on the motility and the secretions of the digestive system: drugs used to treat gastro‐oesophageal reflux disease; antispasmodics; antidopaminergics; prokinetics [Μ.Κ‐P.] 3 hours Actions and interactions of several drugs affecting the gastrointestinal motility (Pharmacology, experiments on isolated gastrointestinal preparations of lab animals) 35th hour Laxatives: bulk producing laxatives; osmotics; motility stimulant laxatives; lubricant laxatives. Antidiarrhoeal drugs: adsorbent antidiarrhoeal drugs; antimotility antidiarrhoeal drugs [Μ.Κ‐P.] 36th hour Drugs used for the management of inflammatory bowel disease; Antiemetics; Emetics; Anticirrhotics; Choleretics [Μ.Κ‐P.] 3 hours Pharmacokinetics I: Drug Absorption and distribution of drugs in the body (Pharmacology, tutorial) 3 hours Pharmacokinetics II: Elimination of drugs from the body– Clearance and metabolism (Pharmacology, tutorial) 2 hours Drug Analysis I: Chromatographic methods (Pharmacology, tutorial) 2 hours Drug Analysis II: Validation of the chromatographic methods (Pharmacology, tutorial)

159BB. Avian Anatomy‐Physiology 37th hour Thoracoabdominal cavity. Peritoneum, peritoneal cavities. Respiratory system 38th hour Digestive system. Circulatory system 39th hour Urogenital system (male) 40th hour Urogenital system (female) 41th hour Nervous system. Integument 2 hours Birds ‐ chicken mainly (Use of anatomical models and dissection on chicken;male, female) (Gross anatomy)

51 160BC. Labs on animal cadavers 12 X 4 (Gross anatomy)

Grade Distribution of Practical Examination Anatomy(macroscopic and microscopic) 80% Pharmacology 20% Physiology 0%

Final Grade Theory 70% Practicals 30%

52 6th (Ι) Module ‐ 4th Semester

Infectious Agents I Learning objectives This module is dealing witth the morphology, structure , biology and taxonomy of bacterial, viral and fungal microorganisms, which infect domesticated animals. Introductory immunology and immunity against infections are also included. This module also deals with prasitology and protozoal diseases of the most important parasitic organisms which infect domesticated animals in Greece, with additional references of the most important examples elsewhere. The order of lectures will follow the zoological grouping of the parasites , i.e. protozoa, helminths and arthropods. Taxonomy and morphology will focus to the necessary keys for recognition of the organisms and the biological relationships of the taxonomic groups. Furhermore, emphasis will be placed on the principles of the life cycle, mode of infection, dignosis and control of protozoal diseases. The module also includes apiculture and honey‐bee diseases focused on biology, physiology and the diagnosis and control of the most common bee infectious agents in Greece.

1st Section

161BΑ. Introductory Bacteriology 1st hour Introduction to microbiology. History and development of microbiology. Pathogenic microorganisms. Prokaryotes and Eucaryotes. Evolutionary relationships. Biological classification and nomenclature. Contemporary aspects of veterinary microbiology [V.S.] 2nd‐3rd hour Morphology and Structure of the bacterial cells. Shape, size, structure and function [Ε.B‐H.] 4th‐5th hour Bacterial nutrition and metabolism. Bacterial nutrition, growth, multiplication and metabolism [Ε.P.] 6th‐8th hour Bacterial Genetics. Chromose structure, replication, and gene ecpression. Mutations. Recombination. Plasmids and their functions. Congugation, transformation and transduction. Transposons and insertion sequences. Comparative analysis of sequences and evolutionary relationships of bacteria [C.D.] 9th‐10th hour Antimicrobial factors‐Sterilization Disinfection. Normal flora. Bacterial toxins and enzymes. Antimicrobials: mode and site of action antimicrobial resistance. Sterilization, disinfection, antisepsis [Ε.P.] 11th‐12th hour Taxonomy: Classification and Nomenclature of Bacteria. Classifications methods (genotypic, phenotypic, and chemical methods). Major groups of bacteria. International codes of nomenclature. Bergey’s manual of systematic bacteriology. The orders of bacteria [V.S.]

53 162BΒ. Introductory Mycology – Pathogenic yeasts and fungi 13th‐14th hour Introductory mycology: morphology, resistance, distribution. Reproduction, classification [Ε. B‐H.] 15th‐16th hour Moulds: Aetiological agent. Epidemiology, Pathogenesis. Diagnosis [Ε. B‐H.] 17th‐18th hour Yeasts: Aetiological agent. Epidemiology, Pathogenesis. Diagnosis [Ε. B‐H.] 19th‐20th hour Fungal products and toxins. Mycotoxicoses [Ε. B‐H.]

Bacteriology–Μycology (Practicals)

3 hours Safety in the laboratory (Safety procedures) Microscopy Preparation and Fixation of Bacterial Smears ‐ Staining techniques [Ε. B‐H] 3 hours Cultivation of Bacteria. Laboratory Media used for the isolation and identification of bacterial pathogens (preparation of culture media, and basic, enriched, enrichment, selective, or indicator media). Inoculation of culture media. Incubation of inoculated culture plates in aerobic or anaerobic atmosphere. Bacterial gross growth characteristics (on solid‐colonies‐, and in liquid media). Isolation, pure culture technique. Preservation and inactivation of bacteria [V.S.] 3 hours Staining Techniques (Gram, Ziehl‐Nielsen and Giemsa Stain) [Ε.P.] 3 hours Identification of Bacterial Pathogens (Primary and secondary biochemical tests for the Identification of Bacteria) Conventional biochemical tests‐ Reading the biochemical reactionsof the API Antimicrobial Susceptibility Test [Ε.P.] 3 hours Serological Detection and Identification of bacterial pathogens and Measurement of antibodies (Agglutination tests/Rose‐ Bengal & Ring test, Complement Fixation, Enzyme‐linked immunosorbent assay/ELISA). Molecular Detection and Identification of Bacteria. Selected molecular techniques for the detection of slowly growing and uncultivable pathogens. (PCR, Real‐Time PCR, Sequencing, RFLP, Southern blotting) [V.S.] 3 hours Direct Microscopic Examination of Fungi Pathogens. (Isolation and subculture of fungi. Identification based on colonial characteristics, examination of fruiting heads and biochemical reactions in the case of yeasts) [Ε. B‐H.]

163BC. Principles of Virology 21st hour Introduction in Virology (Nature and origin of viruses, viral morphology) [C.D.,M.P.] 22nd hour Viral structure (genome, capsid, envelope, functional properties of virus nucleic acids and proteins) [C.D.,M.P.]

54 23rd hour Chemical composition of viruses–Effect of physicochemical agents on the infectivity of viruses–Viral taxonomy and nomenclature [C.D.,M.P.] 24th hour Viral replication cycle (Strategies of replication‐ attachment, entry and uncoating. Transcription of mRNA, replication of viral DNA or RNA. Assembly, maturation and release of virus particles [C.D.] 25th hour Effects of virus replication in host cells (cytopathic effects, acute infections, subclinical infections, persistent and chronic infections, latent infections. Viral tumorigenicity) [S.K.] 26th hour Effects of host cells in virus replication. Antiviral actions of interferons [S.K.] 27th hour Viral genetics and evolution (mutations, genetic recombination, intramolecular recombination, reassortment, multiplicity reactivation) [C.D.] 28th hour Emerging viruses. Mechanisms of viral emergence [C.D.] 29th hour Genetic engineering. Application of genetic engineering in Veterinary Microbiology. Virus sequence determination and phylogenetic inference [C.D.]

Virology ‐ Immunology (Practicals) (S.K., M.P., C.D.] 1 hour Methods and uses of cell culture, embryonated chicken eggs and experimental animals in virology 1 hour Virus isolation and identification in cultured cells, chick embryos dan experimental animals 1 hour Virus detection and titration using classical methods (Haemagglutination, Haemadsorption, Quantal assays (TCID50, LD50, ID50), Plaque assays) 1 hour Virus detection using molecular techniques (Molecular Hybridization, Polymerase Chain Reaction, Real‐time PCR). Virus detection using Western blotting 1 hour Virus detection using Serum Neutralization test 1 hour Virus detection using Haemagglutination‐inhibition and Agar gel immunodiffusion tests 1 hour Virus detection using ELISA 1 hour Virus detection using Immunofluorescence and Immunoperoxidase staining 1 hour Vaccines and immunity

164BD. Basic Immunology 30th hour Introduction ‐ Antibodies. Nature and properties of antibodies. Epitopes and paratopes. Antigen cross‐ reaction. Haptens [M.P.] 31st hour Antibodies (Molecular weight, size, electrophoretic mobility, antigenicity, structure, variety) [M.P.]

55 32nd hour Immunoglobulins (Clases and subclasses, immunoglobulins G, A, M, E, D, immunoglobulin variety, incomplete or blocking antibodies, monoclonal antibodies) [M.P.] 33rd hour Antibody production. B cell reaction to antigens. Primary and secondary immunoreaction. Factors affecting antibody production. T cell reaction to antigens. Cytotoxic cells. Most important B and T cells properties [M.P.] 34th hour Complement. Action of the complement. Biological consequences from the complement activation. Animal complement properties. The meaning of reduced or increased complement levels in serum [M.P.] 35th hour Histocompatibility antibody production (blood groups). Histocompatibility antigen. HLA system. Histocompatibility systems in animals. Isoantigens and blood groups. Blood transmission syndrome. Animal blood groups [M.P.] 36th hour Regulatory proteins of immunological reactions (cytokines). Interleukins, interferons. lymphokines, monokines [M.P.] 37th hour Innate and acquired immunity (resistance). The antibody role [S.K.] 38th hour Phagocytosis. Complement activation. Neutralization of microbs, toxins. Introduction of passive immunity [S.K.] 39th hour Innate and acquired immunity (resistance). The cell mediated immunity role. Cellular cytotoxicity [S.K.] 40th hour Autoreactions of immunological etiology [M.P.] 41st hour Immunity of the reproduction, of the pregnancy and of the newborn [S.K.] 42nd hour Immunity against infectious agents [S.K.] 43rd hour Allergies and related reactions [M.P.]

2nd Section

165BΕ. Parasitology [A.D, E.P., Μ.P, S.H., S.F.] 44th hour Introduction to Parasitology (general concept for further comprehension of the discipline) 45th hour Protozoan parasites of domestic animals (morphology and life cycle of Trypanosomatidae, Hexamitidae, Monocercomona‐didae) 46th hour Morphology and life cycle of Entamoebidae, Eimeridae, Cryptosporidiidae 47th hour Morphology and life cycle of Toxoplasmatidae, Sarcocystidae, Haemogregarinidae 48th hour Morphology and life cycle of Plasmodiidae, Babesiidae, Theileriidae. Ciliophora 49th hour Metazoa parasites of the domestic animals (in general) 50th hour Trematoda (introduction, morphology and biological cycle of Fasciolidae and Dicrocoeliidae)

56 51st hour Trematoda (morphology and biological cycle of Paramphistomidae, Schistosomatidae, Heterophyidae, Echinistomatidae, Brachylaemidae, Opisthorchiidae and Diplostomatidae) 52nd hour Cestoda (introduction, morphology and biological cycle of Pseudophyllidea) 53rd hour Cestoda (morphology and biological cycle of Anoplocephalidae, Davaineidae, Dilepididae, Hymenolepididae and Mesocestoididae) 54th hour Cestoda (morphology and biological cycle of Taeniidae) 55th hour Nematoda (introduction, morphology and life cycle) 56th hour Nematoda (morphology and life cycle of Ascaridida) 57th hour Nematoda (morphology and life cycle of Rhabditida and Oxyurida) 58th hour Nematoda (morphology and life cycle of Spirurida and Enoplida) 59th hour Nematoda (morphology and life cycle of Strongylida) 60th hour Nematoda (morphology and life cycle of Strongylida) 61st hour Nematoda (morphology and life cycle of Strongylida) 62nd hour Nematoda (morphology and life cycle of Strongylida) 63rd hour Morphology and life cycle of Acanthocephala and Anellida 64th hour Arthropoda (introduction, morphology and life cycle of Ixodoidea) 65th hour Arthropoda (morphology and life cycle of Mesostigmata, Trombidiformes and Sarcoptiformes) 66th hour Insects (introduction, morphology and life cycle of Muscidae, Calliphoridae and Sarcophagidae) 67th hour Insects (morphology and life cycle of Oestridae, Gasterophylidae and Hypodermatidae) 68th hour Insects (morphology and life cycle of Hippoboscidae, Tabanidae, Nematocera anf Phthiriaptera) 69th hour Insects (morphology and life cycle of Siphonaptera, Hemiptera, Coleoptera, Orthoptera, Hymenoptera, Lepidoptera and Trichoptera)

Parasitology (Practicals) [D.A, E.P.,M.P.,S.F.] 1 hour Microscopic demonstration of Trichomonadida, Kinetoplastida ,Sarcodina , Eimeriidae (Discussion on the morphology and the life cycle of the parasites) 1 hour Microscopic demonstration of Sarcocystidae, Haemogregatinidae, Piroplasmidia, Haemosporidia. Ciliophora, Microspora (Discussion on the morphology and the life cycle of the parasites) 1 hour Macroscopic and microscopic demonstration of Fasciolidae, Dicrocoeliidae, Paramphistomidae, Schistosomatidae (Discussion on the morphology and the life cycle of the parasites)

57 1 hour Macroscopic and microscopic demonstrations of Pseudophyllidea, Anoplocephalidae, Davaineidae (Discussion on the morphology and the life cycle of the parasites) 1 hour Macroscopic and microscopic demonstration of Dilepididae, Hymenolepididae, Mesocestoididae, Taeniidae (Discussion on the morphology and the life cycle of the parasites) 1 hour Macroscopic and microscopic demonstrations of Ascaridoidea, Heterakoidea, Rhabditoidea (Discussion on the morphology and the life cycle of the parasites) 1 hour Macroscopic and microscopic demonstrations of Oxyuroidea, Acuarioidea, Habronematoidea, Spiruroidea (Discussion on the morphology and the life cycle of the parasites) 1 hour Macroscopic and microscopic demonstrations of Thelazio‐ idea, Filarioidea (Discussion on the morphology and the life cycle of the parasites) 1 hour Macroscopic and microscopic demonstrations of Strongylidea, Chabertiidae, Syngamidae, Trichostrongylidae, Ancylostomatidae (Discussion on the morphology and the life cycle of the parasites) 1 hour Macroscopic and microscopic demonstrations of Dictyocaulidae, Metastrongylidae, Protostrongylidae (Discussion on the morphology and the life cycle of the parasites) 1 hour Macroscopic and microscopic demonstrations of Trichinellidae, Trichuridae (Discussion on the morphology and the life cycle of the parasites) 1 hour Macroscopic and microscopic demonstrations of Acanthocephala, Anellida, spiders, scorpions (Discussion on the morphology and the life cycle of the parasites) 1 hour Macroscopic and microscopic demonstrations of Ixodoidea (Discussion on the morphology and the life cycle of the parasites) 1 hour Microscopic demonstration of Mesostigmata, Trombidiformes, Sarcoptiformes (Discussion on the morphology and the life cycle of the parasites) 1 hour Macroscopic and microscopic demonstrations of Muscidae, Calliphoridae, Sarcophagidae, Oestridae, Gasterophylidae, Hypodermatidae (Discussion on the morphology and the life cycle of the parasites) 1 hour Macroscopic and microscopic demonstrations of Hippo‐ boscidae, Tabanidae, Nematocera, Phthiriaptera, Sipho‐ naptera, Hemiptera, Coleoptera, Orthoptera, Hymenoptera, Lepidoptera, Trichoptera (Discussion on the morphology and the life cycle of the parasites)

58 166BF. Parasitic Diseases Ι [E.P.] 70th hour Introduction to Parasitic Diseases (general principals of epizootiology/epidemiology, environmental factors influencing the survival, spread and infestation, economical implication of parasitic diseases) 71st hour Introduction to Parasitic Diseases (pathogenesis of parasites, host defence, diagnosis, treatment and action of antiparasitic drugs, prevention and public health) 72nd hour Trypanosomosis, Leishmaniosis (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 73rd hour Giardiosis, Entamoebosis Acanthamoebosis, Negleriosis Blastocystosis, Hexamitosis, Octomitosis, Trichomonadidoses, Balantidiosis (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 74th hour Eimeriosis, Isosporosis, Histomonosis, Cryptosporidiosis (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 75th hour Toxoplasmosis, Neosporosis, Hamondiosis (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 76th hour Sarcocystiosis, Hepatozoonosis, Haemoproteosis, Leucocytozoonosis (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 77th hour Plasmodiosis, Babesiosis, Theileriosis, Besnoitosis, Encephalitozoonosis (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health)

167BG. Bee diseases and culture 78th‐84th hour Bee. Species of bee, Greek breeds, morphology, anatomy and physiology of honey bee. Biology, nutrition and feeding. General principals in bee keeping [E.P.] 85th‐88thhour Infectious and parasitic diseases of adult bee, brood and queen. Toxicosis. Defence mechanisms. Pathogenesis and epizootiology. Methods for hygienic control and prevention of contagious diseases [E.P.)

Bee diseases and culture (Practicals) [E.P.] 6 hours Morhpology, anatomy and physiology of honey bee. Bee hive. Clinical examination and collection of specimens for laboratory examination. Laboratory diagnosis of infectious and parasitic diseases. Demonstration of principal managements in bee culture. Honey as bee and human food. Changes and alteration of honey

59

th 96BMODULE 5 Semester Hours/semester

87BL P ECTS

3rd (ΙΙ) Epidemiology 24 12 3.5

6th (ΙΙ) Infectious Agents II & General Pathology (including General Pathology, Antiinflammatory Drugs, Infectious Diseases, Parasitic Diseases ΙΙ) 134 74 20.0

7th (Ι) Food Sciences Ι (Principles of Hygiene and Technology of Milk and milk products) 18 17 4.0 th 32B8 (Ι) 33BClinical Sciences Ι (including methods of clinical examination and diagnosis, Principles of 41 44 7.5 Radiology, Introduction to the principles of Surgery, Pharmacology, Toxicology)

34BTotal 217 147 35.0

123BElective Topics 1. Alternative methods for parasite control (8 hours lectures) 2. Organization, management and funding of animal production establishments (12 hours lectures, 4 hours practicals) 3. Molecular biology techniques and their applications in veterinary medicine (10 hours lectures, 2 hours practicals) 4. Ostrich, duck and goose production (10 hours lectures, 9 hours practicals) 5. Bioethics (20 hours lectures) 6. Art and the brain (10 hours lectures) 7. Diagnosis of honey bee diseases with emphasis on molecular detection methods (10 hours lectures, 8 hours practicals)

60 Instructors of 5th Semester modules

Adamama‐Moraitou Katerina K.A.‐M. Αgelidis Apostolos Α.Α. Anagnostou Tilemahos T.A. Batzias Georgios G.B. Boscos Constantinos C.Bo. Bourtzi‐Hatzopoulou Elefth. Ε.B‐H. Brellou Georgia G.Br. Brozos Christos C.Br. Diakakis Nikolaos N.D. Diakou Anastasia A.D. Dovas Chrisostomos C.D. Flaskos Ioannis Ι.F. Fletouris Dimitrios D.F. Frydas Stavros S.F. Georgiadis Marios Μ.G. Giadinis Nektarios N.G. Haralabidis Stylianos S.H Kaldrymidou Eleni Ε.Κ. Karagiannopoulou Maria Ma.K. Kazakos Georgios G.Ka. Kiosis Evangelos E.K. Komnenou Anastasia An.K. Koutinas Alexandros Al.K. Koutinas Christos Ch.K. Kritas Spiridon S.K. Kritsepi Maria M.K. Loukopoulos Panayotis P.L. Mylonakis Mathaios M.M. Nikolaidis Efstathios Ε.Ν. Panousis Nikolaos Ni.P.

61 Papadopoulos Elias E.P. Papadopoulou Paraskevi P.P. Papageorgiou Dimitrios D.P. Papaioannou Nikolaos Ν.P. Papanastasopoulou Maria Μ.P. Papazachariadou Margarita Μ.Pz. Papazoglou Lysimahos L.P. Patsikas Michail P.M. Petridou Evanthia Ε.P. Polizopoulou Zoe Z.P. Poutahidis Theofilos T.P. Prassinos Nikitas N.Pr. Psalla Dimitra D.Ps. Psychas Vassilios V.P. Raptopoulos Dimitrios D.R. Sachana Magdalini Μ.S. Savvas Ioannis I.S. Siarkou Victoria V.S. Tzika Eleni E.Tz. Ververidis Haralambos H.V. Vlemmas Ioannis Ι.V.

62 3rd Module (ΙΙ) ‐ 5th Semester

168BLearning objectives Students should develop the ability to consider animal health problems at the population level and to take into account the populations’ collective characteristics, properties and dynamics when formulating approaches for prevention and control of animal disease. Students should develop an appreciation for the multifactorial nature of disease causation and learn how to investigate potential disease causes and use the respective knowledge in disease control and prevention schemes. Students should understand the potential limitations in the performance of diagnostic tests and understand the indices of diagnostic test performance, i.e. sensitivity, specificity and predictive values. They should also learn how to take into consideration the probability of imperfect test results when making clinical or population‐level decisions. They should learn how to describe diseases in animal populations, in terms of time, place and animal and how to interpret such data and use them to generate etiological hypotheses. They should know how to calculate measures of disease frequency in a population (prevalence and incidence measures). They should also learn some basic principles of design and conduct of analytical epidemiological studies, in order to be able to design simple small‐scale studies and to evaluate critically published epidemiologic studies. They should learn some basic principles of infectious disease or pathogen surveillance and be able to conduct an investigation of an infectious disease outbreak in an animal population. They should gain some familiarity with simple software programs of epidemiological analysis and be able to use them to perform some simple actions, like creating and entering data into a questionnaire, perform simple analysis of the results of analytical epidemiologic studies and analyze the results of surveys for disease freedom.

169BEpidemiology 1st–4th hour Objectives and principles of Veterinary Epidemiology. Evolution of animal diseases control . Present situation. Explanations and definitions in Veterinary Epidemiology. Epidemiology and traditional Veterinary Science. Basic Epidemiologic ideas [M.G.] 5th–8th hour Descriptive Epidemiology. Interaction of animals‐pathogens‐ environement. Measurement of disease frequency. Construction of questionnaires for epidemiologic research. Presentation of numerical data [M.G.] 9th‐10th hour Sampling of animal populations [M.G.] 11th‐12th hour Definition of disease endemic level and epidemic – epidemic curves. Outbreak investigation [M.G.]

63 13th‐15th hour Causative factors and risk factors. Factors relating to animal species. Factors relating to the farm and the environment of the animal. Factors relating to the implicated pathogen [M.G.] 16th‐20th hour Analytical Epidemiology. Epidemiologic studies, i.e. retrospective epidemiologic studies, prospective epidemiologic studies. The idea of risk. Identification of risk factors. Investigation of etiologic factors and multifactorial relationships in epidemiologic studies [M.G.] 21st‐22nd hour Interpretation of diagnostic test results. Uncertainty and diagnostic testing. Types of diagnostic tests. Evaluation and comparisons of diagnostic tests. Test results and their interpretation at the animal level. Methodology for selection of normal criteria. Diagnostic tests for determining the disease frequency in production animal populations [M.G.] 23rd‐24th hour Analysis of epidemiologic data concerning animal disease. Investigation of spread of a disease. Evaluation of the productivity and health status of farmed production animals. Theoretical epidemiology (modeling). New technologies and their application in Veterinary Epidemiology [M.G.]

35BPracticals 3 hours Design of Epidemiologic studies, methodology of data collection, methods of statistical analysis and evaluation of results [M.G.] 4 hours Use of computers and necessary software for epidemiologic studies [M.G.] 2 hours Application of statistical models for the evaluation of the relationship of risk factors and implicated factors in an epidemiologic study [M.G.] 3 hours Calculation of descriptive statistics for every studied factor and investigation of relationships between implicated factors and possible risk factors with the aid of specialized software [M.G.]

64 Module 6 (II) ‐ 5th Semester

Pathogenic agents II and General Pathology

Learning objectives

This module provides knowledge in the taxonomy and biology of pathogenic mocroorganisms and the ways in which these pathogens , described in module 6I‐1st section, threaten animals in Greece, spread between countries , herds and individuals; how they invade and persist in the body and how the body reacts to them; how their clinicopathological diagnosis can be confirmed in the laboratory; and the principles upon which control is based. It is hoped that the present module will provide a backround against which pathology and medicine can be taught without having to describe each infectious disease again. This module also deals with the principles of the life cycle, mode of infection, diagnosis and control of helminth and arthropod deseases. The module focuses on the diagnosis of parasitic disease and with control, both in farm and companion animals. Lectures are dealing in more detail with the relationship between the management of animals and parasitism. Mechanisms of resistance of nematodes will be dealt here. Factors leading to the development of drug resistance will be discussed. The aim of General Pathology is to enable students to gain knowledge in as many aspects as: 1. To reinforce the concepts of cellular and tissue injury, inflammation and healing and especially the cellular adaptation to injury, necrosis, inflammation, wound healing, and neoplasia. 2. To provide students with a conceptual understanding of disease processes at the level of cells, tissue and organs. 3. To provide an overview of different general disease states such as circulatory disorders, neoplasia. 4. To allow students to begin to develop skills in observation and pathological interpretation in terms of clinical significance and prognosis. 5. To recognize patterns of organ disease and their functional implications. Students will acquire an understanding of the following: 1. The manifestation of disease states at a cellular level. 2. The consequences of alteration in blood flow to tissues and organs. 3. Concepts of disordered tissue growth.

1st Section

170BGeneral Pathology Cytopathology 1st hour Pathology of the nucleus (aberrations of the cell cycle, inclusions, nucleolus, nuclear necrosis) [V.P.] 2nd hour Pathology of the cytoplasm and organelles (endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes, cytoskeleton) [V.P.]

65 3rd hour Cell pathology associated with metabolic disturbances (fat and carbohydrate disturbances, protein accumulations‐ hyaline change). Pigment accumulations, pathologic calcification [V.P.] 4th hour Cellular aging, apoptosis (definition and causes, mechanisms, examples) [V.P.] 5th hour Cell death: biochemical mechanisms, ischaemic and hypoxic injury, reversible and irreversible cell injury, free radical injury, necrosis [V.P.] 6th hour Pathology of the extracellular matrix. Types of degeneration [D.Ps.] 7th hour Fibrinoid necrosis, fibrosis, extracellular depositions, aberrations of keratinisation [D.Ps.] 8th hour Pathology of the extracellular matrix (amyloidosis, oedema) [D.Ps.] 9th hour Gout and pseudogout [D.Ps.]

171BCirculatory system 10th hour Aberrations of cardiac function. Heart failure [P.L.] 11th hour Hyperaemia. Congestion. Haemorrhage [P.L.] 12th hour Haemostasis and coagulation. Thrombosis [P.L.] 13th hour Disseminated intravascular coagulation. Embolism and types of emboli [P.L.]

172BInflammation‐Immunopathology 14th hour Inflammation. General characteristics of inflammation. Types of inflammation [G.Br.] 15th hour Acute inflammation (vascular changes, cellular elements involved, mediators of inflammation) [G.Br.] 16th hour Chronic inflammation (histological characteristics, cellular infiltration) [G.Br.] 17th hour Granulomatous inflammation (microbial, parasitic) [G.Br.] 18th‐19th hour Hypersensitivity reactions type I, II, III, IV [I.V.] 20th‐22nd hour Pathogenesis of autoimmune diseases. Immunotolerance. Immunodefficiency. Immunopathology of transplantation. Immunopathology of neoplasms [I.V.]

173BDisorders of tissue and organ growth 23rd hour Types of cells based on their replication potential. Regulation of cellular regeneration (cellular contacts, chalones, cellular microenvironment, special regulatory systems) [N.P.] 24th hour Disorders of organ development. Hypertrophy, hyperplasia, atrophy, agenesis, aplasia, hypoplasia, metaplasia, prosoplasia, heteroplasia, dysplasia [N.P.] 25th hour Regeneration. Normal regeneration. Repair regeneration [N.P.]

66 26th hour Wound healing. Bone healing. Nervous tissue healing [N.P.] Neoplasia 27th hour Definition and classification of neoplasms. Preneoplasia (primary intraepithelial cancer, malignant transformation of benign neoplasms) [E.K.] 28th hour Cellular differentiation of neoplastic cells [E.K.] 29th‐30th hour Metastasis: metastatic cascade, patterns, mechanism, genetic basis of metastatic behaviour [E.K.] 31st hour Carcinogenesis: mechanisms, chromosomal aberrations. Intrinsic carcinogenic factors. Extrinsic carcinogenic factors: viral, chemical, radiation [E.K.] 32nd hour Molecular basis of carcinogenesis. Consequences of neoplasia: ectopic hormonal and paraneoplastic syndromes. [E.K.] 33rd‐34th hour Introduction to the morphology, localisation and characteristics of mesenchymal neoplasms [T.P.] 35th‐36th hour Introduction to the morphology, localisation and characteristics of epithelial neoplasms [T.P.]

Practicals [Ε.Κ., I.V., N.P., V.P., T.P., P.L., G.Br. D.Ps.] 2 hours Cellular degeneration. Examples shown: hydropic degeneration, degeneration due to glycogen accumulation, fatty change, scrapie 2 hours Tissue necrosis: liver necrosis, toxic dystrophy of liver, necrosis of striated muscle fibers 2 hours Pigment accumulations in the cytoplasm: anthracosis, haemosiderin accumulation, bile pigment accumulation 2 hours Vascular disorders: thymic haemorrhage, lung haemorrhage, thrombosis, infarct 2 hours Inflammation types classified based on their duration: acute, subacute, chronic inflammation 2 hours Inflammation types classified based on exudate type: catarrhal inflammation, fibrinous inflammation (enteritis, fibrinous pneumonia) 2 hours Viral inflammation: viral encephalitis due to the canine distemper virus, interstitial pneumonia 2 hours Microbial inflammation: granulomatous inflammation (tuberculosis, foreign body inflammation) 2 hours Parasitic inflammation: parasitic pneumonia, liver coccidiasis (granulomatous inflammation) 2 hours Depositions in the extracellular matrix and on the lamina propria: amyloidosis, calcification 2 hours Mesenchymal neoplasms: fibroma, lipoma 2 hours Epithelial neoplasms (papilloma, squamous cell carcinoma), melanoma

67 2 hours Glandular epithelium neoplasms: adenoma, adenocarcinoma 2 hours Neoplasms of haemopoetic tissue: lymphoma, mastocytoma 2 hours Electron microscope. Photographs of various cases 2 hours Special stains used in histopathology, histochemistry and immunohistochemistry

174BAutacoids, NSAIDs, and Glucocorticoids 37th hour Histamine and Serotonine[G.B.] 38th‐39th hour Non‐Steroidal anti‐inflammatory Drugs[G.B.] 40th‐42th hour Glucocorticoids (Corticosteroids) [G.B.]

2nd Section

175BInfectious Diseases Infectious Diseases due to bacteria 43rd hour Bacteria and fungi as aetiological agents of infectious diseases. (Pathogenicity of infectious disease due to bacteria and fungi pathogens) [Ε.B‐H.] 44th hour Epidemiology of Bacterial and Fungal Diseases. Zoonoses. Legislation. Notifable Infectious Diseases [Ε.B‐H.] 45th hour Diagnosis and Prevention of infectious disease due to bacteria and fungi pathogens) [Ε.B‐H.] 46th‐48 th hour Infections due to Staphylococcus and Streptococcus species (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, clinical infections) [Ε.P.] 49th hour Infections due to Corynebacterium species. (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, clinical infections) [Ε.P.] 50th hour Infections due to Actinomyces, Arcanobacterium, Actinobaculum species, Nocardia species and Dermatophilus congoloensis. (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, clinical infections) [Ε.P.] 51st‐52 nd hour Infections due to Listeria and (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, clinical infections) [Ε.P.] 53th‐54 th hour Infections due to Bacillus antrachis (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, clinical infections) [Ε.P.] 55th‐58 th hour Infections due to Clostridium species. (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, clinical infections) [Ε.B‐H.] 59th‐60 th hour Infections due to Mycobacterium species(aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, clinical infections) [Ε.B‐ H.]

68 61st‐62nd hour Infections due to Escherichia coli (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, diseases) [V.S.] 63th‐64th hour Infections due to Salmonella serotypes, Yersinia species, and opportunistic pathogens. (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, diseases) [V.S.] 65th hour Infections due to Pseudomonas aeruginosa & Burkholderia species, and Aeromonas, Plesiomonas & Vibrio species (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, diseases) [V.S.] 66th hour Infections due to Pasteurella species and Mannheimia haemolytica (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, diseases) [V.S.] 67th hour Infections due to Haemophilus species & Taylorella equigenitalis, and Actinobacillus species (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, diseases) [V.S.] 68th hour Infections due to Francisella, Moraxella, and Bordetella species (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, diseases) [V.S.] 69th‐70 th hour Infections due Brucella species (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, clinical infections) [Ε.B‐H.] 71st hour Infections due to Campylobacter species, Lawsonia intra‐ cellularis, Brachyspira hyodysenderiae and Serpulina species (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, clinical infections) [Ε.P.] 72nd‐74th hour Infections due to Leptospira and Borrelia species (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, diseases) [V.S.] 75th hour Infections due to pathogenic non‐spore‐forming Gram‐ negative anaerobic bacteria: Bacteroides, Dichelobacter, Fusobacterium, Prevotella, Porphyromonas species (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, diseases) [V.S.] 76th‐79th hour Infections due to Mycoplasma species (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, clinical infections) [Ε.P.] 80th‐81st hour Infections due to Chlamydia and Chlamydophila species (aetiological agent, epidemiology, pathogenesis and

69 pathogenicity, laboratory diagnosis, prevention, diseases) [V.S.] 82nd‐84th hour Infections due to Rickettsiales sp. (Rickettsia, Aegyptianella, Anaplasma, Ehrlichia & Neorickettsia species) and bacterial species of limited pathogenic significance (aetiological agent, epidemiology, pathogenesis and pathogenicity, laboratory diagnosis, prevention, diseases) [V.S.]

176BViruses and Viral diseases of animals 85th hour Picornaviridae, Caliciviridae, Astroviridae, Togaviridae, Flaviviridae, Coronaviridae & Arteriviridae (Taxonomy, biological and physicochemical properties, pathogenesis) [C.D.] 86th‐87th hour Diseases of bovine, ovine, caprine and lagomorphs caused by viruses of the families Flavi‐, Corona‐ & Calicivirinae: Bovine viral diarrhea /Mucosal disease (Flaviviridae)‐ Border disease (Flaviviridae) ‐ Calf diarrhea (Coronaviridae, Reoviridae, e.t.c.) ‐ Rabbit hemorrhagic disease/European brown hare syndrome (Caliciviridae) [Epidemiology, pathogenesis, diagnostic methods, prevention] [M.P.] 88th‐89th hour Diseases of porcine, bovine, ovine, avian and equine caused by viruses of the families Picorna‐, Flavi‐, Corona‐ & Arteriviridae: Swine encephalomyocarditis (Picornaviridae) ‐ Foot and mouth disease (Picornaviridae) ‐ Classical swine fever (Flaviviridae ‐ Pig transmissible gastroenteritis (Coronaviridae)‐Infectious bronchitis of poultry (Coronaviridae)‐ Porcine reproductive & respiratory syndrome (Arteriviridae)‐ Equine infectious arteritis (Arteriviridae) [Epidemiology, pathogenesis, diagnostic methods, prevention] [S.K.] 90th hour Orthomyxoviridae, Paramyxoviridae, Birnaviridae, Bunya‐ viridae,Bornaviridae, Reoviridae & Rhabdoviridae (Taxonomy, biological and physicochemical properties, pathogenesis) [C.D.] 91st‐92nd hour Diseases of bovine, ovine and caprine caused by viruses of the families Paramyxo‐ & Reoviridae: Enzootic pneumonia of calves and shipping fever pneumonia (Paramyxoviridae) ‐ Rinderpest (Paramyxoviridae) ‐ Peste des petits ruminants (Paramyxovoridae) ‐ Bluetongue (Reoviridae) ‐ Calf diarrhea (Reoviridae) [Epidemiology, pathogenesis, diagnostic methods, prevention] [M.P.] 93rd‐94th hour Diseases of porcine, avian and equine caused by viruses of the families Orthomyxo‐, Paramyxo‐, Reo‐, & Birnaviridae: Swine influenza (Orthomyxoviridae) ‐ Equine influenza (Orthomyxoviridae)‐Avian influenza (Ortho‐myxoviridae)‐ Newcastle disease of poultry (Paramyxoviridae) ‐ Poultry respiratory infection by pneumovirus (Paramyxoviridae)‐

70 African horse sickness (Reoviridae) ‐ Avian Gumboro disease (Birnaviridae) [Epidemiology, pathogenesis, diagnostic methods, prevention] [S.K.] 95th‐96th hour Filoviridae, Retroviridae, Circoviridae, Parvoviridae, Hepadnaviridae, Polyomaviridae & Papillomaviridae (Taxonomy, biological and physicochemical properties, pathogenesis) [C.D.] 97th‐98th hour Diseases of bovine, ovine, caprine, equine, canine and feline caused by viruses of the families Retro‐ & Papillomaviridae: Enzootic bovine leucosis (Retroviridae) ‐ Progressive pneumonia (Maedi/Visna) (Retroviridae)‐ Caprine arthritis/encephalitis (Retroviridae) ‐ Sheep pulmonary adenomatosis (Retroviridae)‐ Bovine, equine, canine & feline papillomatosis (Papillomaviridae) [Epidemiology, pathogenesis, diagnostic methods, prevention] [M.P.] 99th‐100th hour Diseases of porcine and equine caused by viruses of the families Retro‐, Circo & Parvoviridae: Equine infectious anaemia (Retroviridae) ‐ Postweaning multisystemic wasting syndrome of swine (Circoviridae) ‐ Swine parvovirus infection (Parvoviridae) [Epidemiology, pathogenesis, diagnostic methods, prevention] [S.K.] 101st hour Adenoviridae, Herpesviridae, Asfarviridae & Poxviridae (Taxonomy, biological and physicochemical properties, pathogenesis) [C.D.] 102nd‐103rd hour Diseases of bovine, ovine and caprine caused by viruses of the families Herpes‐ & Poxviridae: Infectious bovine rhinotracheitis/Infectious pustular vulvovaginitis‐ valanoposthitis (Herpesviridae)‐Malignant catarrhal fever (Herpesviridae) ‐ Contagious ecthyma (orf) (Poxviridae)‐ Sheeppox and Goatpox (Poxviridae) [Epidemiology, pathogenesis, diagnostic methods, prevention] [M.P.] 104th‐105th hour Diseases of porcine, avian and equine caused by viruses of the families Herpes ‐ & Asfarviridae: Pseudorabies (Aujeszky’s) disease (Herpesviridae) ‐ Equine rhinopneumonitis (Herpesviridae ‐ Avian Μarek’s disease (Herpesviridae)‐African swine fever (Asfarviridae) [Epidemiology, pathogenesis, diagnostic methods, prevention] [S.K.] 106th hour Prion Diseases: Bovine spongiform encephalopathy ‐ Scrapie [Epidemiology, pathogenesis, diagnostic methods, prevention] [M.P.] 107th hour Diseases of canine caused by viruses of the families Corona‐, Rhabdo ‐ & Paramyxoviridae: Coronavirus enderitis (Coronaviridae) ‐ Rabies (Rhabdoviridae) ‐ Distember (Paramyxoviridae) [Epidemiology, pathogenesis, diagnostic methods, prevention] [M.P.]

71 108th hour Diseases of canine caused by viruses of the families Parvo‐, Adeno‐, & Herpesviridae: Parvoenteritis (Parvoviridae) ‐ Infectious hepatitis (Adenoviridae) ‐ Infectious Tracheobronchitis (Herpesviridae) [Epidemiology, pathogenesis, diagnostic methods, prevention] [M.P.] 109th hour Diseases of feline caused by viruses of the families Corona‐ & Caliciviridae: Infectious peritonitis (Coronaviridae) ‐ Calicovirus disease (Caliciviridae) [Epidemiology, pathogenesis, diagnostic methods, prevention] [M.P.] 110th hour Diseases of feline caused by viruses of the families Parvo‐ & Retroviridae: Panleukopenia (Parvoviridae) ‐ Leukemia (Retroviridae) ‐ Acquired immunodeficiency syndrome ‐ (Retroviridae) [Epidemiology, pathogenesis, diagnostic methods, prevention] [M.P.]

Practicals 7x2 hours Practicals on Bacteriology and Animal Bacterial Diseases [Ε. B‐CH, E.P, V.S., S.K., C.D.] 6x2 hours Practicals on Virology and Viral diseases of animals [M.P., S.K., C.D.]

3rd Section Parasitic Diseases II [A.D., E.P., M.P., S.F.] 111th hour: Trematodosis of productive animals (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 112th hour Trematodosis of companion animals (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 113rd hour Cestodosis of productive animals (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 114th hour Cestodosis of companion animals (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 115th hour Cysticercosis, Coenuriosis of productive animals (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 116th hour Echinoccocosis of productive animals (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 117th hour Nematodoses of gastrointestinal tract of birds (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health)

72 118th hour Nematodoses of gastrointestinal tract of swine (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 119th hour Nematodoses of gastrointestinal tract of swine (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 120th hour Nematodoses of gastrointestinal tract of equids (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 121st hour Nematodoses of gastrointestinal tract of equids (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 122nd hour Nematodoses of respiratory system of carnivores (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 123rd hour Nematodoses of gastrointestinal tract of carnivores (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 124th hour Nematodoses of gastrointestinal tract of carnivores (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 125th hour Nematodoses of carnivores caused by non‐enteric parasites (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 126th hour Nematodoses of ruminants caused by non‐enteric parasites (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 127th hour Nematodoses of gastrointestinal tract of ruminants (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 128th hour Nematodoses of respiratory system of ruminants (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 129th hour Αcanthocephalosis and diseases caused by leeches in domestic animals (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 130th hour Arthropodosis of productive animals caused by acari (mange) (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 131st hour Arthropodosis of companion animals caused by ticks (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 132nd hour Arthropodosis of companion animals caused by ticks (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health)

73 133rd hour Arthropodosis of productive and companion animals caused by insects (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health) 134th hour Arthropodosis of productive and companion animals caused by insects (etiological agent, epizootiology, pathogenesis, diagnosis, prevention, public health)

Practicals [E.P.,M.P.,S.F.] 1 hour It is described or demonstrated and performed: a) The goals and the conditions for the parasitological faecal examination, b) The collection of the faecal sample, the preservation and the conditions under which it will be send out to the laboratory, and c) Direct smear method. Samples of faeces with reproductive elements of certain representative species of protozoan and metazoan parasites are used and the morphological features which are used for the identification of the parasites are specified. Also, permanent preparations and forms of reproductive elements of parasites are used 1 hour Flotation method. Samples of faeces with reproductive elements of certain representative species of protozoan and metazoan parasites are used and the morphological features which are used for the identification of the parasites are specified. Also, permanent preparations and forms of reproductive elements of parasites are used 1 hour Sedimentation method. Samples of faeces with reproductive elements of certain representative species of protozoan and metazoan parasites are used and the morphological features which are used for the identification of the parasites and the diagnosis of the disease are specified. Also, permanent preparations and forms of reproductive elements of parasites are used 1 hour Modified Mcmaster method. Samples of faeces with reproductive elements of certain representative species of protozoan and metazoan parasites are used and the morphological features, which are used for the identification of the parasites and the diagnosis of the disease, are specified. Also, permanent preparations and forms of reproductive elements of parasites are used 1 hour It is described or demonstrated and applied: a) simplified faecal examination for detecting L1 larvae and, b) the Baermann method. Faecal samples with L1 larvae are used and the morphological features that are used for the identification of the parasites and the diagnosis of the disease are specified. Also, forms of reproductive elements of parasites are used

74 1 hour It is described or demonstrated and applied the methodology of faecal examination for detection of oocysts of Cryptosporidium spp. Fresh faecal samples, along with stained preparations of Cryptosporidium spp and forms of reproductive elements of parasites are used 1 hour It is described or demonstrated and applied: a) the urine parasitological examination, b)The Giemsa –stain method, c) the modified Knott method. Blood samples with L1‐ Dirofilaria spp and L1‐Dipetalonema spp are used and the morphological features which are used for the identification of the parasites and the diagnosis of the disease are specified. Also, stained preparations of blood with amastigotes and promastigotes forms of Leishmania spp and forms of reproductive elements of parasites are used 1 hour It is described or demonstrated and applied: a) the examination method for detecting endodermic parasites causing mild or intense skin lesions, b) the Graham method, c) the method for examining the outer ear canal, and d) the method for examining the skin surface and fur. Preparations with mites and ticks and their morphological features which are used for the identification are specified. Also, preparations with oxyurid eggs and forms of reproductive elements of parasites are used 1 hour It is described or demonstrated and applied: a)The muscle tissue compression method b) the method of xenodiagnosis and c) the method of autopsying the organs (liver, lungs, intestine, heart ). Also, stained preparations of muscle tissue with Sarcocystis spp and forms of reproductive elements of parasites are used 1 hour It is described or demonstrated and applied: a) The artificial digestion of muscle tissue method. Muscle tissue samples from infected rodents with L1‐Trichinella spp. are used. Also, stained preparations of muscle tissue with L1‐ Trichinella spp. and forms of reproductive elements of parasites are used 1 hour It is described or demonstrated and applied: a) The method of seeking reproductive elements from protozoan and metazoan parasites on pasture, b) the method of seeking house dust mites, c) the method of seeking mites( Dermanyssus spp.) on grounds and ticks on pasture, and d) techniques for the preservation of metazoan parasites. Fresh or stained preparations with mature oocysts, with L3 larvae from ruminants coproculture etc. are used 1 hour It is described and evaluated the results from the serological tests (ELISA etc) in diagnosing parasitic diseases (leishmaniosis, toxoplasmosis, dirofilariosis and

75 hydatidosis). Also, it is reported the application and is specified the significance of the molecular techniques (PCR and modifications) in the diagnosis of the parasitic infections 1 hour It is described the methodology to detect resistance of parasites to antiparasitic drugs 1 hour Revision (Flotation method) 1 hour Revision (Sedimentation method) 1 hour Revision (Baermann method)

76 7th (Ι) Module ‐ 5th Semester

114BFood Sciences Ι Learning objectives

The aims of this module are to enable participants to understand the basic principles of the hygiene and technology of milk and dairy products and to apply the principal experimental techniques (chemical and microbiological) for their laboratory exami‐ nation. Upon successful completion of the module, participants are expected to understand and be able to comment and answer questions about the basic principles governing the manufacturing technology and hygiene status of milk and dairy products; their chemical composition and physicochemical properties; their quality control and inspection; the principal microbiological and physicochemical methods for their laboratory examination and quality assessment; the basic principles of HACCP and the legislation in force pertaining to their manufacture.

One Section

Principles of hygiene and technology of milk and milk products 1st hour General aspects of milk. The chemical composition of milk. Factors that influence the chemical composition of milk. Colostrum [D.F.] 2nd hour Physical properties of milk. The nutritive value of milk [D.F.] 3rd hour Microbiology of raw milk. Effect of the milk microflora on milk properties. Major dairy fermentations [A.A.] 4th hour Unsanitary and abnormal milk. Milkborne infections and intoxications. Off‐flavors and abnormal taste of milk [A.A.] 5th hour Chemical contaminants in milk [D.F.] 6th hour Hygienic production, storage and transport of raw milk. Collection and storage of milk. Raw milk collection and refrigeration centers. Hazard Analysis Critical Control Point (HACCP) system implementation in milk production [A.A.] 7th hour Raw milk standards and quality control (microbiological standards, freshness, hygienic status, chemical composition) [A.A.] 8th hour Pasteurised milk (pasteurisation, packaging, storage and transport). Effect of the pasteurisation process on milk. Inspection of pasteurised milk and regulatory aspects [D.P.] 9th hour The manufacture, packaging and storage of sterilised, long‐ life (U.H.T.), sterilised condensed, sweetened condensed milk, dried milk, infant milk formulae and other milk‐based products. Their microbiology and defects. Quality control and regulatory aspects [D.P.]

77 10th hour Fermented milk products. The manufacture, types, pasteurisation, packaging, storage conditions, and the shelf‐life of yoghurt. Yoghurt microbiology. Yoghurt defects and quality control [A.A.] 11th hour The manufacture of fermented milk products other than yoghurt (cultured milk, acidophilus milk, Bulgarian buttermilk, Kefir, Koumiss). Regulatory aspects [A.A.] 12th hour The manufacture, packaging and storage of cream and butter. Microbiology and defects of cream and butter. Quality control and regulatory aspects [D.F.] 13th hour Basic ingredients and additives for cheesemaking. Cheesemaking operations. Modern systems of cheesemaking [D.P.] 14th hour The various cheese types. The Greek P.D.O. cheeses: their packaging and storage. Caseins and caseinates. Milk whey and its utilization. Regulatory aspects [D.P.]

15th hour Cheese microbiology and public health. Cheese defects. Quality control and regulatory aspects [D.P.] 16th hour Ingredients for ice cream manufacture. The manufacture, microbiology and defects of ice cream. Quality control and regulatory aspects [D.F.] 17th hour Fundamentals of dairy plant sanitation. The cleaning and sanitizing of apparatus and equipment, the chemicals used and the cleaning and sanitizing steps. Cleaning In Place. Sanitation monitoring. Sources of contamination [D.F.] 18th hour HACCP implementation in the production of milk and dairy products [D.P.]

Practicals [A. A., D. P., D. F.] 2 hours Sampling of milk and dairy products. Two‐ and three‐class sampling plans 2 hours Determination of the fat content of milk (Gerber method) Determination of the specific gravity, the Total Solids and the Total Solids Non Fat of milk. Detection and quantitation of milk adulteration 2 hours Modern methods of microbiological analysis of milk. Determination of the total bacterial counts. Determination of the Total Mesophilic Count of milk 2 hours Enumeration of Enterobacteriaceae and Staphylococcus aureus in milk and dairy products. 2 hours Determination of the pH and the titratable acidity of milk. Phosphatase test. Methylene Blue Reduction test 2 hours Inspection of pasteurised, sterilised (U.H.T.), evaporated, sweetened condensed milk, milk powder, yoghurt, cultured milk, cream, butter, cheeses and ice cream

78 2 hours HACCP implementation in the manufacture of dairy products (in‐class exercise) 3 hours Training visit in a dairy processing plant

Final Grade Theory 60% Practicals 40%

79 8th (Ι) Module ‐ 5th Semester

Clinical Sciences Ι

88BLearning objectives Clinical examination and diagnostics: This course offers practical training on the methods of clinical examination and diagnostic approach of all body systems in companion and productive animal species. It also teaches students how to obtain samples and perform basic clinical pathology tests and interpret their results, along with the basic principles of therapeutics (administration of medications, intensive care of hospitalized animals). Principles of radiology: It offers basic principles of radiography, ultrasonography, computed tomography and magnetic resonance imaging and their use in the investigation of animals` disease. It introduces students in radiation safety and teaches how to interpret radiographs and recognize the normal radiographic anatomy. Introduction to the principles of surgery: To introduce students to the disciplines of surgery and to practice surgical suture patterns. Pharmacology: To understand the basic principles of chemotherapy and obtain specific knowledge of selected substances or chemotherapeutic agents ‐ which are chemicals that are intended to be toxic for the invading micro‐organisms or cancer cells but innocuous to the host ‐ involved in animal chemotherapy (antiseptics and disinfectants, antimicrobials, antifungals, antivirals, anthelmintics and anticancer drugs). Toxicology: To understand the basic principles of veterinary toxicology and obtain specific knowledge of toxicological aspects of selected substances involved in animal poisoning.

1st Section

Methods of clinical examination and diagnosis (practical courses 12x3 hours) Practical Course 1 Medical history and records [M.K.] Handling methods of the horse ‐ Clinical examination of the horse [N.D.] Physical examination of cattle [Ni.P.]

Practical Course 2 Physical examination of the dog [K.A.‐M.] Physical examination of the cat [Z.P.] Physical examination of small ruminants [N.G.]

80 Practical Course 3 Physical examination of pigs. Diagnostic approach of health problems in commercial pig farms [E.Tz.] Diagnostic approach of health problems in small ruminant herds [N.G.] Clinical examination of the rumen, reticulum, omasum and abomasum in cattle, collection of ruminal contents samples [Ni.P.]

Practical Course 4 Complete blood counts, urinalysis [M.K.] Collection of blood and urine samples and administration of medications in pigs [E.Tz.] Collection of blood and urine samples in dogs and cats [K.A.‐M.]

Practical Course 5 Collection of blood and urine samples, administration of drugs, nasogastric intubation in the horse [N.D.] Clinical examination of the female reproductive system in large animals, vaginoscopy, vaginal cytology, biopsy of the vagina and uterus [E.K.] Rectal examination in large animals [C.Br.]

Practical Course 6 Clinical examination of the udder in large animals [E.K.] Clinical examination of the male reproductive system [H.V.] Collection and examination of semen [C.Br.]

Practical Course 7 Fluid therapy in dogs and cats, parenteral nutrition, drug dose calculation [I.S., T.A.] Oral fluid intake in dogs and cats, nursing care [G.Ka., T.A.] Neurological examination in the dog [Z.P.]

Practical Course 8 Lymph node aspiration and cytology in the dog [M.M.] Orthopedic examination in the dog and the cat [Ni.P.] Dermatological examination in the dog and the cat [Ch.K.]

Practical Course 9 Examination of the eyes and adnexa in the dog [An.K.] Cardiac auscultation in the dog [Ch.K.] Reproductive history questionnaire and examination‐card recording. Clinical examination of the reproductive system in the male and female dog [H.V.]

Practical Course 10 Canine vaginal swab collection, cytological interpretation and other reproductive system laboratory examinations [H.V.] Collection of blood and urine samples, esophageal catheterization and administration of medications in small ruminants [N.G.] Collection of urine samples in cattle [Ni.P.]

81

Practical Course 11 Lameness examination / colic examination in the horse [N.D.] Administration of intravenous fluids and oral or parenteral medications in cattle (neonatal and adult animals) [Ni.P.] Administration of intravenous fluids and oral or parenteral medications in small ruminants (neonatal and adult animals) [N.G.]

Practical Course 12 Bone marrow aspiration and cytology [M.M.]

177BPrinciples of Radiology 1st hour Radiation Physics (types of radiation and their use in medicine, radioactive elements, electromagnetic spectrum). Production of X‐Rays (x‐ray tubes, models of x‐ ray production, X‐ray spectrum). [P.M.] 2nd hour X‐Ray Properties (interaction of x‐rays with matter, physical, chemical and biologic properties of x‐rays) [P.P.] 3rd hour Principles of Radiographic Interpretation (basic concept of making a radiograph, film processing, factors affecting image detail and contrast, radiographic geometry, technical errors) [P.P.] 4th hour Basic and Special Radiographic Procedures (radiography, fluoroscopy, oesophagography, gastrography, cystography, myelography and other contrast studies) [P.P.] 5th hour Principles of Radiation Safety (cosmic and radon radiation, medical x‐ray radiation,basic radiation safety rules for diagnostic radiology)[P.M.] 6th hour Normal Radiographic Anatomy (forelimbs, pelvic limbs, head, cervix, spine, thorax, abdomen, pelvic) [P.M.]

178B Introduction to the principles of Surgery 7th hour Wounds I [Fundamentals of wound management (lavage, debridement, drainage and bandages)] [L.P.] 8th hour Wounds II (Types of wound healing, flaps and grafts) [L.P.] 9th hour Wound III (Bites, pressure sores, wounds of the limbs, gunshot wounds, burns) [L.P.] 10th hour Wound healing complications, surgical infections and antibiotics (Abscess, seroma, hematoma, dehiscence, infection types, principles of antibiotic prophylaxis) [L.P.] 11th hour Suture materials and patterns, wound closure materials, hemostasis and cautery (physical, biological and mechanical properties of sutures, suture size, suture selection, surgical needles, ligatures, staples and tissue adhesives, suture patterns and applications, surgical hemostasis, ligatures and surgical clips) [L.P.]

82 Practicals (N.D., Ma.K., L.P., N.Pr.) 2 hours Surgical instruments, asepsis and sterilization (most common instruments, principles of sterilization, surgical asepsis, theatre design) 2 hours Sutures patterns, suture materials, surgical knots

179BAntimicrobial drugs 12th‐13th hour Introduction. Pharmacokinetic/Pharmacodynamic correlation. Bacterial resistance [G.B.] 14th hour Β‐lactams I‐penicillins [G.B.] 15th hour Β‐lactams II‐Cephalosporins and Cephamycins, Carbapenems, Monobactams, Peptide antibiotics (Glycopeptides, Polymyxins, and Bacitracin) [G.B.] 16th hour Aminoglycosides and Aminocyclitols ‐ Lincosamides [G.B.] 17th hour Macrolides [G.B.] 18th hour Chloramphenicol, Thiamphenicol, and Florfenicol [G.B.] 19th hour Tetracyclines ‐ Pleuromutilins [G.B.] 20th hour Sulphonamides, Diaminopyrimidines and their Combinations [G.B.] 21th hour Fluoroquinolones [G.B.] 22nd hour Miscellaneous Antibiotics: Rifamycins, Novobiocin, Nitrofurans, and Nitroimidazoles [G.B.] 23rd hour Antiviral Drugs [G.B.] 24th hour Antifungal Drugs [G. B.] 25th hour Antiseptics‐Disinfectants [G.B.] th th 26 ‐29 hour Antiparasitic drugs Anthelmintics: Benzimidazoles/Pro‐ benzimidazoles, Imidazothiazoles, Tetrahydropyrimidines, Avermectins/Milbemycins, Salicylanilides/Substituted Phe‐ nols, Aromatic amides, Miscellaneous anthelmintics. Drugs against ectoparasites: Organophosphates, Carba‐ mates, Pyrethrins/Pyrethroids, Formamidines and Miscellaneous ectoantiparasitics. Antiprotozoans [Ε.Ν.] 30th‐31st hour Antineoplastic and Immonosuppressive Agents. Alkylating agents, Nitrogen mustards, Ethylenimide derivatives, Alkyl sulfonates, Nitrosoureas, Triazenes, Antimetabolites, Folic acid analogs, Pyrimidine analogs, Purine analogs, Natural products: Vinca alcaloids, antibiotics, enzymes. Platinum coordination complexes, Miscellaneous antineoplastic agents and corticosteroids [Ε.Ν.]

180BToxicology 32nd hour General principals of toxicology (history and aim of toxicology/principles of toxicology/toxicity mechanisms /risk assessment) [Ε.Ν.] 33rd hour Bioavailability of toxic substances (absorption, distribution and excretion of toxic substances, biotransformation of xenobiotics, toxicokinetics) [Μ.S.]

83 34th hour Systemic toxicity (chemical carcinogenesis/toxicogenetics / developmental toxicology) [Μ.S.] 35th‐36th hour Target organ toxicity (blood, immune system, liver, kidney, respiratory system, nervous system, cardiovascular system, reproductive system, endocrine system, skin, eye) [E.N., Ι.F.] 37th‐39th hour Toxic agents (toxic actions of: pesticides, metals, solvents, animal toxins, plants) [Ι.F., Ε.Ν.] 40th hour Environmental toxicology (air pollution, ecotoxicology) [Ε.Ν.] 41st hour Toxicological applications (food/analytical/forensic/clinical toxicology) [Μ.S.] Practicals [V.‐P. Κ. Κ., Ε.Ν., Μ.S., Ι.F.] 2x2 hours Laboratory detection of toxic substances in biological samples

84

MODULE 6th Semester Hours/semester

89BL P ECTS Food Sciences ΙΙ (including microbiology of food of animal origin, general principles of processing and 7th (ΙΙ) quality assurance of food of animal origin, Hygiene and quality assurance of game and honey) 20 22 4.0

7th (ΙΙI) Farming and Pathology of Aquatic Organisms 26 16 4.5

Clinical Sciences II (including Diseases, Surgical Management and Pathology of the Cardiovascular, 8th (ΙΙ) Hematopoietic, Diagnostic Imaging, Respiratory and Urinary System, Reproductive Disorders and Pathology 139 48 20.0 of the Dog and Cat, Disorders of the Udder)

4BTotal 185 86 28.5

124BElective Topics 1. Issues in analytical and applied epidemiology (10 hours lectures, 10 hours practicals) 2. Aquatic environment‐Interactions between environment and aquaculture (12 lectures, 12 hours practicals)

Instructors of 6th Semester modules Adamama‐Moraitou Katerina K.A.‐M. Agelidis Panayotis P.A. Ambrosiadis Ioannis Ι.Α. Amin Αmbrahim Ab.Αm. Boscos Constantinos C.Bo. Brozos Christos C.Br. Diakakis Nikolaos N.D. Giadinis Nektarios N.G. Ιosifidou Eleni Ε.Ι. Κaldrymidou Eleni Ε.Κ.

85 Karagiannopoulou Maria Ma.K. Karatzias Harilaos H.K. Kiosis Evangelos E.K. Koutinas Christos Ch.K. Kritsepi Maria M.K. Loukopoulos Panayiotis P.L. Mylonakis Mathaios M.M. Panousis Nikolaos Ni.P. Papavergou Aikaterini Α.P. Papazoglou Lysimahos L.P. Papaioannou Nikolaos P.N. Papagianni Maria Μ.P. Papadopoulou Paraskevi P.P. Papapanagiotou Elias E.P. Patsikas Michail P.M. Poutahidis Theofilos T.P. Psalla Dimitra D.Ps. Psychas Vassilios V.P. Sergelidis Daniil D.S. Soultos Nikolaos Ν.S. Tzika Eleni E.Tz. Vatsos Ioannis I.V. Ververidis Haralambos H.V. Vlemmas Ioannis Ι.V Ζetou Fani F.Ζ.

86 7th (ΙΙ) Module ‐ 6th Semester

115BFood Sciences ΙI

Aims

The aims of this module are to enable students to understand the basic principles of food microbiology, technology and quality assurance of food of animal origin and to apply the principal microbiological and chemical techniques for their laboratory examination.

Learning Objectives

Upon successful completion of this module, students are expected to understand and be able to comment and answer questions about the basic principles governing the manufacturing technologies and hygiene status of food of animal origin; their chemical composition; methodologies of quality and safety assurance; inspection and systematic assessment of the food safety assurance systems; principal micro‐ biological and physicochemical methods for their laboratory examination; legislation aspects, hygiene and quality assurance of game and honey.

One Section

181BFood, an introduction. General Principles of Microbiology of Food of Animal Origin 1st‐2nd hour Groups of food microorganisms. Factors affecting the growth of microorganisms in foods (intrinsic factors I: pH buffering capacity, water activity) [Ν.S.] 3rd‐4th hour Intrinsic factors II: redox potential (Eh), food antimicrobial factors, food nutrients availability, food texture. Extrinsic factors: temperature, relative humidity, gaseous atmosphere, etc.) [Ν.S.] 5th hour Combination of intrinsic‐extrinsic factors. Microbial hurdles [Ν.S.] Practicals [Αm.Αb., Ε.Ι., Ν.S.] 3 hours Sampling of foods of animal origin. Use of media for the microbiological examination of foods 3 hours Aerobic Plate Count and counts of special groups of microorganisms (psychrotrophic, thermophilic, yeasts‐ fungi) 3 hours Coliforms and E. coli counts 3 hours Detection and identification of Salmonella spp. in foods of animal origin. Classical and rapid methods General Principles of processing of Food of Animal Origin 6th‐7th hour Thermal processing. Methods, applications, products. Chilling and freezing of foods. Methods, applications, products [Μ.P.]

87 8th‐9th hour Irradiation of food. High‐pressure treatment. Concentration. Drying. Chemical methods of food preservation (salting, curing, smoking, acidification). Use of preservatives (antimicrobial substances). Protective cultures, bacteriocins. Food packaging [Α.P.] 10th hour Microbiology of heat processed foods (mechanism‐ parameters of thermal destruction of microorganisms, heat‐resistance and factors affecting heat‐resistance of microorganisms). Microbiology of chilled and frozen foods (effects of chilling and freezing on microorganisms) Factors affecting the effect of freezing on microorganisms. [Ν.S.] 11th hour Microbiology of irradiated foods (effect of irradiation treatment on microorganisms, radio‐resistance of various groups of microorganisms, factors affecting the radio‐ resistance of microorganisms. Microbiologfy of dried foods and effects of drying on microorganisms. Effect of chemical preservatives‐antimicrobial substances on microorganisms [Ν.S.]

Practicals [Ι.Α., Α.P., Μ., .P F.Ζ.] 2 hours Canning (containers, materials, properties, technology, principles of thermal processing, thermal processing systems). 2 hours Methods of chemical analysis of food (determination of meat protein content (BEFFE), fat, carbohydrate and moisture contents). Methods for determination of the caloric value of foods.

182BGeneral principles of quality assurance of food of animal origin 12th hour Introduction to principles and methodologies of the modern quality assurance and food safety systems. Applications, advantages and drawbacks [Ι.Α.] 13th hour Principles and methodologies of the rules of good manufacturing practice. Development and application of the rules of good hygienic practice. Various prerequisites for the application of the systems (tra ining of the personel, inspections of suppliers etc.). [Ι.Α.] 14th hour Principles and methodologies of hazard determination and risk assessment. [I.A.]. 15th‐17th hour hour Principles and methodologies of the HACCP system. Construction and application of HACCP systems for food production in the whole of the food chain. [Ι.Α.] 18th hour Inspection and systematic assessment of the food safety assurance systems [Ι.Α.]

183BPracticals (A) [Ι.Α., Μ.P., Α.P., F.Ζ.] 2 hours Hazard analysis in the production line of canned tuna.

88 2 hours Construction and application of HACCP systems in selected food industries. Determination of hazards and critical control points. 2 hours Exercises in developing and applying the rules of good manufacturing practice in food production units. Development of auditing forms.

184BHygiene and Quality Assurance of Game Animals and Honey 19th‐20th hr Inspection, specifications, spoilage and transportation of game and honey. Regulatory aspects [E.P.]

Final Grade Theory 80% Practicals 20%

89 7th (ΙΙI) Module ‐ 6th Semester

Farming and Pathology of Aquatic Organisms

Aims Familiarization of the undergraduate veterinary students with the theoretical and the practical aspects of fish and shellfish farming. Convey the knowledge and skills, required for the identification and treatment of the health problems observed in farmed aquatic animals.

Learning objectives 1. Knowledge of the current status of the Aquaculture industry in Greece and worldwide 2. Familiarization with the fish and shellfish farming systems (facilities, equipment, production cycles) used for marine and freshwater species, through lectures. 3. Familiarization with the diagnostic procedures used in veterinary practice (how to obtain a complete case history, collection of environmental and fish samples, necropsy, microbiological and histological examination of tissue samples) 4. Familiarization of the procedures used in aquaculture to control diseases (sanitation protocols, disinfection procedures, vaccination, application of chemotherapeutic treatments) 5. Knowledge of the infectious and non infectious diseases of the cultured aquatic animals (fish and shellfish). 6. Practical experience and skills in physical handling of farmed aquatic fish and shellfish. 7. Practical experience and skills in post mortem examination of fish and shellfish (normal anatomy and histology, pathologoanatomical and histopathological alterations observed in the various diseases). 8. Familiarization with the fish and shellfish farming systems after visiting intensive fish farms, mussel culture sites and packing facilities for live mussels.

One Section

1st hour Aquaculture in Greece and Worldwide. [P.A.] 2nd hour Psysical and chemical properties of the water used in aquaculture [I.V.] 3rd hour Fish farming systems ‐ facilities, fresh water farming. [I.V.] 4th hour Marine aquaculture (sea bream ‐ sea bass, hatcheries) [I.V.] 5th hour Marine aquaculture (sea bream ‐ sea bass, on‐growing) [I.V.]

90 6th hour Farming of marine species other than sea bream and sea bass (“new species”) [P.A.] 7th hour Shellfish farming [P.A.] 8th hour H.A.C.C.P. – I.S.O in aquaculture [P.A.] 9th hour Introduction to aquatic animal pathology[P.A.] 10th hour Case history, collection and examination of samples [P.A.] 11th hour Methods of diagnosis of fish diseases [I.V.] 12th hour Disease prevention. [P.A.] 13th hour Treatments of fish diseases [I.V.] 14th hour Viral diseases of fish [P.A.] 15th hour Viral diseases of fish [P.A.] 16th hour Viral diseases of fish [I.V.] 17th hour Bacterial and fungal diseases of fish [P.A.] 18th hour Bacterial and fungal diseases of fish [I.V.] 19th hour Bacterial and fungal diseases of fish [I.V.] 20th hour Bacterial and fungal diseases of fish [I.V.] 21st hour Parasitic diseases of fish [I.V.] 22nd hour Parasitic diseases of fish [I.V.] 23rd hour Parasitic diseases of fish [P.A.] 24th hour Neoplasias, nutritional disorders and syndromes [I.V.] 25th hour Environmental diseases of aquatic animals [P.A.] 26th hour Diseases of shellfish [P.A.]

Practicals [P.A., I.V.] 2 hours Fish anatomy and physiology. Fish histology and elements of histopathology. 2 hours Necroscopic examination – collection of sample. Shellfish anatomy. 4 hours Operation of intensive re‐circulating fish farming systems – equipment – treatments (field visit to a fish farm). 4 hours Operation of a marine hatchery (visit to a commercial hatchery for euryhaline fish species). 4 hours Operation of depuration and packing facilities for shellfish (visit to mussel culture facilities).

Final Grade Theory 60% Practicals 40%

91 8th (II) Module ‐ 6th Semester

Clinical Sciences II

This module covers the cardiovascular, the respiratory and the urinary systems of livestock and companion animals. In addition, the reproductive system of carnivores and the mammary gland disorders of livestock.

90BLearning objectives Cardiovascular system: to understand the pathologic and pathophysiologic basis, clinical manifestations, diagnostic approach and the medical and surgical treatment of the vascular, pericardial, myocardial and endocardial diseases, haematopoietic and lymphatic system diseases; to obtain elementary knowledge on the fundamentals of surgical oncology. Respiratory system: to understand the pathologic and pathophysiologic basis, diagnostic approach, clinical manifestations and medical and surgical treatment of the respiratory diseases. Urinary system: to understand the pathologic and pathophysiologic basis, diagnostic approach, clinical manifestations and medical and surgical treatment of the diseases affecting the urinary system. Reproductive system: to understand the pathologic and pathophysiologic basis, diagnostic approach, clinical manifestations and medical and surgical treatment of the diseases affecting the reproductive system of carnivores; to become familiar with the udder health of productive animals.

Necropsy

To introduce students to biopsy and necropsy procedures. 1. To perform necropsy in all animal species in order to understand and learn the occurrence, development and progression of pathological lesions in body systems and to individual organs, and to relate their morphology at gross and microscopic level to clinical recognizable functional defects and disease states. 2. To study and interpret necropsy and macroscopic lesions in such a way as to make a meaningful diagnostic assessment in relation to “in vivo” clinical observations. Students will acquire 1. Knowledge of the pathogenesis and pathology of clinically important/common animal diseases to provide a foundation for their clinical studies. 2. Further enhancement of their observational, descriptive and interpretive skills in problem‐solving exercises using clinico‐pathological material and laboratory data.

92 3. Further reinforcement of the principles of disease diagnosis and an appreciation of the value of further investigation/research.

1st Section

The Cardiovascular System

97BPathology of the Cardiovascular System 1st hour Congenital anomalies of the heart and large vessels. Pericardium. Non‐inflammatory lesions of the pericardium: Hydropericardium. Haemopericardium. Pneumopericardium. Serous atrophy of pericardiac fat. Calcification of the epicardium. Inflammatory lesions of the pericardium: fibrinous, suppurative (or gangrenous), constrictive and tuberculous pericarditis [V.P.] 2nd‐3rd hour Myocardium. Hyperaemia, haemorrhage of the heart and its membranes. Hypertrophy, atrophy, degeneration, necrosis, calcification of the myocardium. Infarct. Cardiomyopathies of the dog, cat and cattle. Myocarditides. Swine encephalomyocarditis, mulberry heart disease. Neoplasms [V.P.] 4th hour Endocardium. Degenerative lesions of the endocardium. Subendocardial fibrosis. Subendocardial calcification. Endocardiosis of the dog. Endocarditides: valvular, mural, parasitic. Sequelae of endocarditis [V.P.] 5th hour Vascular diseases. Degenerative lesions of arteries: arteriosclerosis, atherosclerosis, arterial calcification, arteriolosclerosis. Aneurysm, arterial rupture. Thrombosis and embolism. Venous dilation, lymphagiectasia. Inflammatory lesions of vessels: arteritis, phlebitis, thrombophlebitis, parasitic arteritis. Dirofilariosis. Lymphangeitis. Classical swine fever and swine erysipelas. Equine: femoral artery thrombosis, equine viral arteritis, African horse sickness. Vascular neoplasms [V.P.]

98BDiagnostic approach 6th hour Clinical examination of the cardiovascular system [Ch.K.] 7th hour Diagnostic approach of cardiac diseases [Ch.K.]

99BCardiovascular diseases of the Dog and Cat 8th‐9th hour Etiology and pathogenesis of cardiac disease [Ch.K.] 10th hour Endocardosis of the atrioventricular valves of the dog [Ch.K.] 11th hour Bacterial endocarditis in the dog, Cardiac tamponade in the dog [Ch.K.] 12th hour Dilated cardiomyopathy in the dog [Ch.K.] 13th hour Hypertrophic cardiomyopathy in the cat, arterial hypertension [Ch.K.] 14th hour Canine dirofilariosis [Ch.K.] 15th hour Cardiac arrhythmias in the dog and cat [Ch.K.]

93 16th hour Congenital heart disease in the dog and cat (introduction), lymphoedema [Ch.K.] 17th hour Effects of other systemic diseases on the cardiovascular system [Ch.K.]

100BRadiographic interpretation in Cardiovascular Diseases 18th hour Disorders of the great vessels of the thorax (increase and decrease of the pulmonary arteries and veins width). Diseases of thecardiac valves (endocardiosis, endocarditis). Myocardialdiseases (dilated and hypertrophic cardiomyopathy). Ultrasonographic interpretation of the diseases [P.M.] 19th hour Drofilariosis. Congenital heart diseases. Heart neoplasms. Pericardialeffusion. Diseases of the spleen (splenomegaly, neoplasia,torsion). Diseases of the thyme and intrathoracic lymph nodes. Ultrasonographic interpretation of the diseases [P.M.] Haematopoietic and lymphatic system

101BPathology 1st hour Thymus: degeneration, inflammation, hyperplasia, neoplasia of the thymus. Bone marrow: circulatory and quantitative alterations, metabolic disorders, bone marrow inflammation. Lymph nodes: metabolic disorders, pigment accumulations, specific inflammatory diseases of lymph nodes. Caseous lymphadenitis. Pseudotuberculosis. Histoplasmosis. Swine circovirus lymphadenitis. Leishmaniasis [V.P.] 2nd hour Spleen: congenital and acquired structural anomalies. Metabolic and degenerative disorders. Spleen torsion and rupture. Circulatory disorders. Thrombosis. Haemorrhage. Inflammation: hyperaemic and hyperplastic splenitis. Specific inflammatory diseases of the spleen. Nodular hyperplasia, atrophy, splenomegaly. Anthrax. Neoplasms [V.P.] 3rd hour Piroplasmosis. Erlichiosis. Feline viral leukaemia. Feline viral immunodeficiency. Toxicosis due to pesticides with anticoagulative properties. Iron deficiency anaemia of piglets. Equine infectious anaemia. Haemolytic diseases. Canine leptospirosis. Lymphoma [V.P.]

102BDiagnostic approach (clinical pathology) 4th hour Physical examination, microscopic examination of blood smears [M.K., M.M.] 5th hour Cytological examination of bone marrow and lymph node smears, diagnostic approach of bleeding disorders [M.K., M.M.]

103BHematopoietic system disorders in the dog and cat 6th hour Immune‐mediated hemolytic anemia [M.M.]

94 7th hour Canine babesiosis and ehrlichiosis, feline hemotropic mycoplasmosis [M.M.] 8th hour Blood loss anemia, anemia of chronic renal disease, anemia of chronic disease, hypoplastic/aplastic anemia [M.M.] 9th hour Neutropenic diseases in the dog and cat, canine leukemias [M.M.] 10th hour Feline leukemia virus, feline immunodeficiency virus [M.M.] 11th hour Immune‐mediated thrombocytopenia, hereditary and acquired thrombocytopathies [M.M.] 12th hour Hemophilias, anticoagulant rodenticide poisoning [M.M.] 13th hour Disseminated intravascular coagulation [M.M.] 14th hour Diseases of the spleen and thymus [M.M.] 15th hour Blood transfusion [M.M.] 16th hour Canine lymphoma and hemangiosarcoma [M.M.] 17th hour Basic principles of chemotherapy, paraneoplastic syndromes [M.M.]

185BIntroduction to Surgical Oncology, Surgery of the Spleen in the dog and cat 18th hr Surgery of the spleen in the dog and cat: splenic torsion, splenectomy [L.P.] 19th hr Principles of surgical oncology in the dog and cat: biopsy techniques, techniques in oncologic surgery [L.P.]

186BDiseases of the circulatory system in cattle 20th‐21th hour Endocarditis, pericarditis, diseases of veins and arteries. Anaemias. Blood coagulation disturbance. Bacillary haemoglobinuria, leptospirosis, babesiosis, anaplasmosis, heatstrike [Ni.P.]

187BDiseases of circulatory system in small ruminants 22th‐23th hour Anaemias, tick born diseases, leptospirosis [Ν.G.]

188BDiseases of circulatory system in swine 24th hour Encephalomyocarditis, classical swine fever, African swine fever, erysipelas, mulberry heart disease, nutritional microaggiopathy, iron deficiency anemia, eperythrozoonosis, thrombocytopenia [Ε.Τz.]

2nd Section

The Respiratory System

104BPathology of the respiratory system 1st‐2nd hour Nasal cavity ‐ paranasal sinuses: Congenital anomalies. Metabolic disorders (amyloidosis etc) Circulatory disorders. Inflammation. Serous, catarrhal, suppurative, fibrinous, granulomatous rhinitis. Sinusitis. Neoplasms. Larynx, trachea, bronchi: congenital and acquired anomalies. Circulatory disorders. Inflammation. Necrotic laryngitis. Bronchectasia [I.V.]

95 3rd‐4th hour Lungs: Atelectasia. Emphysema. Circulatory disorders of the lungs: a) hyperaemia, b) haemorrhage, c) oedema, d) embolism. Pneumonia. Classification of pneumonias: a) lobular pneumonia‐bronchopneumonia, b) lobar‐fibrinous pneumonia, c) interstitial pneumonia, d) bronchointerstitial pneumonia, e) granulomatous pneumonia, f) embolic pneumonia. Neoplasms. Pleura and thoracic cavity. Pneumothorax. Circulatory disorders, hydrothorax, chylothorax, haemothorax. Pleuritis. Neoplasms [I.V.] 5th‐6th hour Cattle. Infectious bovine rhinotracheitis. Bovine enzootic pneumonia. Pneumonic mannheimiosis. Contagious bovine pleuropneumonia. Bovine tuberculosis. Parasitic pneumonia. Small ruminants. Verminous pneumonia. Maedi. Caprine arthritis‐encephalitis. Ovine pneumonic mannheimiosis‐ septicaemic pasteurellosis of lambs. Contagious caprine pleuropneumonia. Parasitic pneumonia. Jaagsiekte [I.V.] 7th hour Swine. Atrophic rhinitis. Swine influenza. Porcine reproductive and respiratory syndrome. Porcine enzootic pneumonia. Porcine pasteurellosis. Porcine pleuropneumonia [I.V.] 8th hour Equine. Equine viral rhinopneumonitis. Equine influenza. Equine viral arteritis. Feline. Feline respiratory syndrome (feline viral rhinotracheitis, respiratory disease due to calicivirus, feline pneumonitis. Rabbit. Pasteurellosis [I.V.]

105BClinical examination of the respiratory system 9th hour Physical examination of the upper airway tract. Sneezing‐ cough‐respiratory distress. Diagnostic evaluation [K.A.‐M.] 10th hour Physical examination of the lower airway tract. Physical examination of the pleural cavity. Diagnostic evaluation [K.A.‐M.]

106BRespiratory diseases of the dog and cat 11th hour Feline viral upper respiratory disease. Feline chronic rhinitis‐sinusitis syndrome. Fungal rhinitis. Canine aspergillosis. Feline cryptococcosis. Parasitic rhinitis.Nasal foreign bodies [K.A.‐M.] 12th hour Reverse sneezing. Canine lymphoplasmacytic rhinitis. Feline nasopharyngeal polyps. Neoplasms of the nasal cavity. Laryngitis. Laryngeal edema‐spasm. Brachycephalic airway syndrome. Laryngeal tumors [K.A.‐M.] 13th hour Infectious tracheobronchitis. Tracheal collapse. Tracheal tumors [K.A.‐M.] 14th hour Canine acute bronchitis. Canine chronic bronchitis. Feline bronchial asthma ([K.A.‐M.]

96 15th hour Viral pneumonia. Bacterial pneumonia. Protozoal pneumonia (toxoplasmosis‐pneumocystosis). Eosinophilic pneumonia [K.A.‐M.] 16th hour Pulmonary thromboembolism. Lung lobe torsion. Lung abscess. Pickwickian syndrome. Paraquat poisoning. Aspiration pneumonia [K.A.‐M.] 17th hour Pulmonary hypertension. Pulmonary edema. Lung tumors [K.A.‐M.] 18th hour Pleural effusion [K.A.‐M.] 19th hour Pneumothorax. Mediastenitis. Pneumomediastinum. Mediastinal tumors [K.A.‐M.]

107BSurgery of the upper respiratory tract, thoracic cavity and heart in the dog and cat 20th hour Surgery of the bracycephalic airway syndrome. Surgical treatment of laryngeal paralysis and laryngeal trauma [L.P.] 21st hour Surgery of the trachea: tracheal resection and anastomosis, tracheal trauma. Surgical treatment of tracheal collapse. Tracheostomy [L.P.] 22nd hour Surgery of the thorax: thoracotomy, thoracic trauma, surgery of the thoracic wall, surgical treatment of pleural effusions [L.P.] 23rd hour Surgery of the lungs. Principles of cardiac surgery [L.P.]

108BRadiographic interpretation of the diseases of the Respiratory System 24th hour Nasal cavities (rhinitis, aspergillosis and neoplasia in dogs and cats, infection of the equine paranasal sinuses). Larynx (paralysis, abscess, neoplasia). Trachea (tracheal collapsing, foreign bodies, neoplasia). Bronchial tree (chronic bronchitis, bronchial asthma) [P.M.] 25th hour Lungs (pulmonary patterns, pneumonia and bronchopneumonia in dogs and cats, equine pneumonia, lung lobe torsion, pulmonary thromboembolism, abscess, oedema, neoplasia ). Pleural cavity (pleural effusion, pleural neoplasia). Mediastinum (mediastinal masses, mediastinitis, pneumomediastinun) [P.M.]

5BDiseases of the Equine Respiratory System 26th hour Clinical examination, sinusitis, ethmoid hematoma, tympany of the guttural pouch, guttural pouch empyema, laryngeal hemiplegia, infectious arteritis, influenza, rhinopneumonitis [N.D.] 27th hour Infection by Streptocoocus spp., bacterial pneumonia, bacterial pleuropneumonia, chronic obstructive pulmonary disease, exercise‐induced pulmonary hemorrhage, pulmonary edema [N.D.]

6BSurgery of the Equine Respiratory System 28th hour Trephination of the sinuses, deviation of the nasal septum, cleft palate, dorsal displacement of the soft palate, epiglottal entrapment [N.D.]

97 29th hour Laryngotomy, Ventriculectomy and prosthetic laryngoplasty, Surgical drainage of guttural pouch empyema, tracheotomy [N.D.]

7BCattle respiratory diseases 30th hour Rhinitis, catarrhal laryngotracheitis, necrotic laryngitis (calf diphtheria), pulmonary edema (cause, symptoms, diagnosis, prognosis, treatment) [H.K.] 31th hour Acute alveolar emphysema, chronic alveolar emphysema, interstitial pulmonary emphysema, pulmonary edema and grazing emphysema [H.K.] 32th‐33th hour Pasteurellosis, mycoplasmosis, haemophilosis, IBR, BRSV, PI3, tuberculosis, parasitic pneumonia ((Dictiocaulus viviparous), purulent pneumonia, fungal pneumonia. [Ni.P.]

189BSmall ruminant respiratory diseases 34th hour Pasteurellosis (pulmonary, septicaemic) [Ν.G.] 35th hour Maedi, pulmonary adenomatosis [Ν.G.] 36th hour Mycoplasma pneumonias (pleuropneumonia, atypical pneumonia) [Ν.G.] 37th hour Parasitic bronchopneumonia [Ν.G.] 38th‐39th hour Pseudotuberculosis, enzootic intranasal tumor, tuberculosis, oestrosis [Ν.G.]

190BSwine respiratory diseases 40th‐41st hour Swine influenza. Infection by Circovirus type 2 and coronavirus. Enzootic pneumonia. Pleuropneumonia. Pneumonic Pastereurellosis. Atrophic rhinitis. Infection by Corynebacterium pyogenes and other bacteria (Streptococcus spp, Mycoplasma spp, Haemophilus parasuis). ΠροInfection by Ascaris suum and Metastron‐ gylus spp. Porcine respiratory disease complex. Tuberculosis [Ε.Τz.]

3rd Section

The Urinary System

8BPathology of the urinary system 1st hour Kidney. Gross and microscopic lesions associated with uraemia (renal and extrarenal). Developmental anomalies of the kidney and ureter. Renal hyperaemia and haemorrhage. Renal infarct. Necrosis of the cortex and medulla. Hydronephrosis [N.P.] 2nd hour Glomerulonephritis [N.P.] 3rd hour Renal amyloidosis. Acute tubular necrosis. Nephrotoxic agents. Pigment depositions. Disorders of the interstitial tissue and tubules. Non‐suppurative interstitial nephritis. Suppurative interstitial nephritis‐pyelonephritis [N.P.]

98 4th hour Renal neoplasms. Urolithiasis. Prostatitis. Hyperplasia and neoplasms of the prostate. Urinary bladder. Cystitis. Enzootic haematuria [N.P.]

9BDiagnostic approach 5th hour Physical examination of the kidneys and lower urinary tract. Disorders of micturition. Urinalysis (urine collection, physical and chemical properties, sediment examination) [K.A.‐M.] 6th hour Hematuria. Pyuria. Urine crystals. Cylindruria. Bacteriuria. Special diagnostic tests [K.A.‐M.]

10BKidney, lower urinary tract and prostatic diseases of the dog and cat 7th hour Acute renal failure [Ch.K.] 8th‐9th hour Chronic renal failure [Ch.K.] 10th hour Glomerular diseases [Ch.K.] 11th hour Nephrotic syndrome. Chronic nephritis in canine leishmaniosis [Ch.K.] 12th hour Canine leptospirosis. Chronic tubulointerstitial nephritis [Ch.K.] 13th hour Kidney tumors. Bacterial urinary infections. Canine pyelonephritis [Ch.K.] 14th hour Urolithiasis. Urinary bladder neoplasia [K.A.‐M.] 15th hour Feline lower urinary tract syndrome [K.A.‐M.] 16th hour Benign prostatic hypertrophy/hyperplasia. Prostatic retention cysts. araprostatic cysts [K.A.‐M.] 17th hour Acute and chronic prostatitis. Prostatic abscess. Prostatic neoplasia [K.A.‐M.]

11BSurgery of the urinary system in the dog and cat 18th‐19th hour Surgery of the kidneys and ureters. Renal trauma. Nephrectomy and nephrotomy. Ureteral trauma. Surgery of the ectopic ureters [Ma.K.] 20th hour Surgery of the urinary bladder. Cystotomy, cystectomy and cystostomy. Urinary bladder trauma [Ma.K.] 21st hour Surgery of the urethra. Urethral trauma. Urethral prolapse. Urethral obstruction. Urethrotomy and urethrostomy. Surgical management of urinary incontinence in the female dog. Urethral neoplasms [Ma.K.] 22nd hour Surgery of the prostate. Surgery of the prostatic cysts, abscessation and neoplasms [L.P.]

12BRadiographic interpretation of the diseases of the Urinary and Female Genital System 23rd hour Kidneys (end stage kidneys, pyelectasis and ureteral dalation, polycystic kidney disease, abscess, neoplasia). Urinary bladder (cystitis, urolithiasis, neoplasia). Urethtra (lithiasis, neoplasia, urethtra obstruction). Ultrasonographic interpretation of the diseases [P.M.] 24th hour Ovaries (ovariancysts, neoplasia).Uterus (pregnancy, age of pregnancy, involuted uterus,endomitritis and cystic

99 hyperplasia of uterus, extrauterus pregnancy, fetaldeath and mummification, pyomytra , neoplasia,). Mammary glands (neoplasia, lymph drainage of the neoplastic mammary glands, imaging investigation of the mammary sentinel lymph node). Ultrasonographic interpretation of the diseases [P.P.]

13BSurgery of the Equine Urinary System 25th hour Urolithiasis, Rupture of the urinary bladder, laparocystotomy, laparocystorrhaphy, perineal urethrostomy [N.D.]

191BUrinary System diseases in cattle 26th‐27th hour Kidney diseases (nephrosis, nephritis, contagious pyelonephritis). Urinary bladder diseases (cystitis, haemorrhagic cystitis,bladder immotility) [Ni.P.]

192BCattle Surgery of the urinary system 28th hour Urolithiasis, urethrotomy and urethrostomy [H.K.]

193BSmall ruminant urinary diseases 29th hour Urolithiasis [Ν.G.]

The Reproductive system of carnivores ‐ Mammary gland

194BPathology 1st hour Ovary. Developmental anomalies of the ovary. Haemorrhage of the ovary. Ovarian cysts – cystic degeneration of the ovary. Ovarian neoplasms. Hydrosalpinx, salpingitis, pyosalpinx. Uterus. Endometritis, metritis, perimetritis. Pyometra. Inflammation of the uterus associated with specific agents [P.L.] 2nd hour Pathology of the uterus in pregnancy. Uterine neoplasms. Canine transmissible venereal tumour. (localization in both genders, pathogenesis, gross and microscopic features, cytology) [P.L.] 3rd hour Mammary gland. Mastitis in the dog and cat. Mammary neoplasms in the dog and cat (types and differential diagnosis based on histopathology; prognostic factors) [P.L.]

195BReproductive disorders of the bitch and queen 4th hour Ovarian cycle, conception and pregnancy [C.Bo.] 5th hour Pregnancy disorders (toxemia, pregnancy related or aggravated disorders). Non‐infectious causes of pregnancy loss (endocrine abnormalities, immune, genetic, environmental, dietetic factors, drugs etc.) [C.Bo.] 6th hour Infectious causes of pregnancy loss [(bacteria: Βrucella, Campylobacter, Salmonella, E.Coli, Streptococci), (viruses: Herpes virus, Parvo‐virus type 2, Distemper virus), Mycoplasma, Ureoplasma and (parasites: Toxoplasma gondii, Neospora caninum)] [C.Bo.]

100 7th hour Parturition: Endocrinology of, initiation, stages and completion of parturition. Drug induced parturition [H.V.] 8th hour Dystocia: Predisposing factors and criteria for the diagnosis and treatment of dystocia. Primary and secondary uterine inertia. Obstetric manipulations (digital‐ , forceps‐ and hook‐) through vagina to relieve dystocia [H.V.] 9th hour Caesarean section [H.V.] 10th hour Postpartum period: Care of the bitch and the neonates. Postpartum disorders: abnormal maternal behaviour, uterine prolapse, retention of foetal membranes, metritis, sub‐involution of placental sites haemorrage, mastitis, agalactia, eclampsia [H.V.] 11th‐12th hour Surgical and non‐surgical control of reproductive activity– prevention and termination of unwanted pregnancy Ovariohysterectomy (standard method by midline approach). Specific features of the bitch and queen. Complications during and after surgery (short and long term). Other surgical methods of spaying dogs and cats (ovariohysterectomy, ovariectomy, hysterectomy, oviduct ligation) and alternative approaches (lateral abdominal and laparoscopic. Hormonal blockage of cyclic activity and post‐mismating prevention of implantation [H.V.] 13th hour Surgical and hormonal termination of unwanted pregnancy [H.V.] 14th hour Ovarian and oviductal disorders. Pathophysiology [H.V.] 15th‐16th hour Uterine disorders: congenital abnormalities, hydrometra, mucometra, haemometra, metritis. Cystic endometrial hyperplasia – pyometra syndrome (clinical signs, diagnosis and treatment). Vaginal disorders: congenital abnormalities, clitoral hypertrophy, vaginitis, vaginal discharge, vaginal hyperplasia/fold prolapse. Transmissible venereal tumour, fibroma, polyp and other tumours (clinical signs, diagnosis and treatment) [H.V.] 17th‐18th hour External genitalia and mammary gland disorders. Pseudopregnancy [H.V.] 19th hour Infertility. Aetiology and treatment of disorders associated with normal cyclic activity, prolonged or shortened interoestrous intervals, prolonged oestrous cycles, absence of oestrous cycles, etc. Specialized obstetric surgery of the reproductive system: episiotomy, vaginal surgery (tumour and stricture excision etc.), vulval surgery (reconstruction of malformed, stenotic or atretic vulva etc.), ovarian remnant exploration and excision (after failed ovariectomy) [H.V.] 20th hour Suppression of reproductive potential of stray dogs and cats [H.V.]

101 196BUdder health of productive animals 21st hour Alterations and bovine mastitis of various causative agents (Streptococcus spp., Staphylococcus spp., Mycoplasma spp., Corynobacterium spp., Colibacillosis, Τuberculosis and other granulοus mastitis). Lesions of udder in small ruminants–Mycoplasma agalaxia of goats and sheep [D.Ps.] 22nd hour Defense mechanisms of udder. Factors affecting udder defense [D.Ps.] 23rd hour Checking a cow suffering from mastitis. Case record, clinical examination, measurement of SCC. Milk abnormalities. Evaluation and assessment of various diagnostic approaches [Ε.Κ.] 24th hour Mastitis caused by Staphylococcus spp. and Streptococcus spp. Environmental mastitis [Ε.Κ.] 25th hour Summer mastitis, mastitis caused by Mycoplasma spp. and fungi [Ε.Κ.] 26th hour Small ruminant mastitis [C.Br.]

Practical training in the Clinics and Necropsy Room (rotation) 1 In the Clinic of Companion Animals and in the Large Animal Clinic: 36 hours/student 2 In the Necropsy Room: 12 hours/student

102

MODULE 7th Semester Hours/semester

91BL P ECTS

rd 3 (ΙΙΙ) 14BVeterinary Deontology and Legislation 12 1.5

Food Sciences ΙΙΙ [including Management and operation of slaugtherhouses, processing and quality of meat, Hygiene and inspection of meat, Hygiene and 7th (ΙV) quality assurance of eggs and poultry meat, 60 52 11 Production and Assurance of Hygiene and Quality of products of Animal Origin, Hygiene and Quality assurance and technology of seafood. Foodborne human infections. Slaughterhouses (meat inspection)]

Clinical Sciences III (including Diseases, Surgery, Diagnostic Imaging and Pathology of the Alimentary System, Pathophysiology of reproduction and 8th(ΙΙΙ) pathology of the male and female reproductive system, Modern methods of artificial insemination and 167 39 22 reproduction management)

15BTotal 239 91 34.5

Elective topics 1. Infectious diseases of major importance for Greece (28 hours lectures and tutorials) 2. Physicochemical and organoleptic methods for assessing the quality of food – Basic principles of food chemistry (6 hours lectures, 15 hours practicals) 3. Diseases of farmed aquatic animals (12 hours lectures, 18 hours practicals) 4. Entrepreneurship and innovation (21 hours lectures and practicals) 5. Comparative Pathology of Neoplasia (12 hours lectures, 6 hours practicals)

Instructors of the 7th Semester modules Αmbrosiadis Ioannis Ι.Α. Amin Αbrahim Αb.Αm. Αrsenos Georgios G.Α. Boscos Constantinos C.Bo. Brozos Christos C.Br. Diakakis Nikolaos Ν.D. Giadinis Nektarios N.G.

103 Ιosifidou Eleni Ε.Ι. Karatzias Harilaos H.K. Kamarianos Athanasios A.K. Karamanlis Xanthippos X.K. Kiosis Evangelos E.K. Κοidis Pavlos P.Κ. Komnenou Anastasia An.K. Loukopoulos Panayotis P.L. Panousis Nikolaos Ni.P. Papadimitriou Serafim S.P. Papagianni Maria Μ.P. Papadopoulou Paraskevi P.P. Papapanagiotou Elias E.P. Papavergou Aikaterini Α.P. Papazoglou Lysimahos L.P. Patsikas Michail P.M. Poutahidis Theofilos T.P. Psalla Dimitra D.Ps. Rallis Timoleon T.R. Sergelidis Daniil D.S. Soultos Nikolaos Ν.S. Tzika Eleni E.Tz. Tsakmakidis I I.T. Tsousis Georgios G.T. Ζetou Fani F.Ζ.

104

3rd (ΙΙΙ)Module ‐ 7th Semester

16BVeterinary Deontology and Law

Learning objectives Information about ethical, historical, legal, and administrative aspects of veterinary profession in relation to animal use. Identification of problems relating to veterina‐ rian/client relationships, veterinarian/veterinarian relationships, emerging issues, the conflict between food quality and the ethical treatment of animals. Knowledge concerning the demands of farm and companion animal health, clients, industry, employers, veterinary profession. Knowledge of veterinary ethics and laws about animal welfare as it applies to most forms of animal use. Basic information and knowledge of responsibilities of veterinarian with respect to companion animals, large animals, food safety, public health, wild animals, zoo animals, exotic animals and animals used in research.

1st‐2nd hour Veterinary Deontology and law, definitions. Professional ethics ‐ code of good practice. Advertisement, relations with colleagues, professional and public organizations. Obligations to customers ‐ animal owners, and Obligations to sick animals. Deontology of research ‐ experiments involving live animals. Veterinary fees [G.Α.] 3rd–4th hour Veterinary law in Greece and the European Union. General principles of Administrative laws and European Community law. Legislative frame for practicing vets. Rights and duties of the veterinarian ‐ categories of responsibilities for practicing vets. Laws associated with animal science: Legal requirements and documentation required for the establishment of livestock enterprises, Assurance of health and welfare of farm animals, animal transport, Animal feeds [G.Α.] 5th‐6th hour EU Food Legislation. Document COM (1999)‐719 Final. COM (2002)‐377 ‐ Final. Regulation (EC) No 178/2002, Regulation (EC) No 852/2004, Regulation (EC) No 853/2004 and Regulation (EC) No 854/2004 [E.P.] 7th‐8th hour EU Food Legislation. Commission Regulation (EC) No 2073/2005, Commission Regulation (EC) No 2074/2005, Commission Regulation (EC) No 2075/2005, Commission Regulation (EC) No 2076/2005 και Regulation (EC) No 882/2004. Commission Decision 2001/471. Council Directive 2002/99 and Directive 2004/41 [E.P.] 9th‐10th hour International and National Conventions regarding the Protection and Conservation of the Wild Fauna. EU Directive 1992/43. International CITES Convention. International Whaling Convention. African Convention.

105 The Bonn and Bern Convention. The Barcelona Convention. The World Heritage Convention. SPAMI Protocol. Σύμβαση OSPAR. ACCOBAMS Agreement [Αn.Κ.] 11th‐12th hour Legislation for Stray Dogs L/3170/2003. Health regulations, for pet non‐ commercial transportation. Veterinary regulations for pet transportation in/from EU and in/from Third Countries. Ministry Directive 208261/2003 [An.K]

106 7th (ΙV) Module ‐ 7th Semester

116BFood Sciences ΙΙΙ

1st Section Aims

The aims of this section are to enable students to understand the basic principles of management and operation of slaughterhouses and production, hygiene, inspection and quality assurance of meat, poultry meat and eggs.

Learning Objectives

Upon successful completion of this section, students are expected to understand and be able to comment and answer questions about regulation aspects and the basic principles governing construction, management and operation of industrial slaughterhouses; critical control points and risk analysis in mammalian and poultry slaughterhouses; ante mortem and carcass inspection; classification of carcasses; meat quality, physicochemical characteristics and nutrient value of meat.

109BA. Management and Operation of Slaughterhouses. Production and Quality Assurance of Meat. Hygiene and Inspection of Meat

1st hour The national and international role of the veterinarian in food safety and consumer protection. Regulatory aspects [D.S.] 2nd hour Management and operation of industrial slaughterhouses. Construction, Specifications. Slaughter lines (bovine, swine and small ruminants). Conditions for establishment and operation. Regulatory aspects [D.S.] 3rd‐4th hour Ante mortem inspection. Health certificate and transportation mode check. Animal health and general condition examination. Resting of the animals (advantages, disadvantages). Regulatory aspects [D.S.] 5th hour Stunning. Bleeding. Dressing. Electrical stimulation [D.S.] 6th hour Cleaning. Disinfection of slaughterhouses. Slaughterhouses hygiene check [D.S.] 7th hour Hazard analysis and critical points in dressing stages of carcasses [D.S.] 8th‐10th hour Carcass inspection. Carcass health marking. Regulatory aspects [N.S.] 11th‐14th hour Abnormalities and pathological lesions found during inspection of animal carcasses [E.I.] 15th‐17th hour Description of some diseases of animal carcasses. Emergency slaughter. Confiscations. Regulatory aspects.

107 Occupational diseases. Prophylaxis of workers in the slaughterhouses [E.P.] 18th hour Classification of carcasses. Identification and labeling of beef meat [Ι.Α.] 19th hour Chilling of the animal carcasses. Processing of by‐products [Ι.Α.] 20th hour Primal and retail cuts of carcasses. Packaging of fresh meat [Ι.Α.] 21st‐22nd hour Post mortem histological and physicochemical changes of carcasses. Biochemical changes during rigor mortis. Cold shortening. Ripening of meat. PSE and DFD meat. Artificial ripening of meat [Ι.Α.] 23rd‐24th hour Meat quality. Organoleptical characteristics (colours, odor, aroma, taste). Water holding capacity of the meat (WHC) and affecting factors. Tenderness of meat and factors affecting it. Nutrient value of meat [Ι.Α.] 25th‐26th hour Meat spoilage [E.P.]

110BManagement and Operation of Slaughterhouses. Production and Quality Assurance of Meat. Hygiene and Inspection of Meat (Practical courses)

18 hours Training in meat inspection in slaughterhouses [P.K., E.I., Am.Ab., N.S., E.P., D.S.] 2 hours Design of slaughterhouses [P.K., E.I., Am.Ab., N.S., E.P., D.S.] 2 hours PSE and DFD meat identification. NaCl and phosphoric acids effects on the water holding capacity (WHC) of meat [Ι.Α., Μ.P., Α.P., F.Z.] 2 hours Evaluation of surface contamination of carcasses (bovine, swine, goats, sheep, poultry) [Am.Ab.]

111BB. Hygiene and Quality Assurance of Poultry Meat and Eggs

27th‐28th hour Management and operation of poultry slaughterhouses. Regulatory aspects. Ante mortem and post mortem inspection. Lesions. Confiscations. Public Health protection from diseases transmitted by poultry meat. Critical control points and risk analysis in poultry slaughterhouses [P.K.] 29th‐30th hour Chilled and frozen carcasses of poultry. Poultry meat products (production, hygiene, preservation, inspection, lesions). Regulatory aspects. Critical control points and risk analysis. Eggs and egg‐products (egg yolk, egg white, whole egg, fresh‐frozen‐dehydrated and other products). Production, hygiene, preservation, inspection, lesions, regulatory aspects [P.K.]

112BHygiene and Quality Assurance of Poultry Meat and Eggs (practicals) [P.K.]

108 3 hours Training in poultry slaughterhouses 2 hours Demonstration‐Inspection of eggs

Production and Assurance of Hygiene and Quality of Meat – Based Products Hygiene and Quality Assurance of Fish Foodborne Diseases Waste Management

2nd Section Aims

The aims of this section are to enable students to understand the basic principles of hygiene, production technologies and inspection of meat and fish based products and food production waste management.

Learning Objectives Upon successful completion of this section, students are expected to understand and be able to comment and answer questions about the basic principles governing production and assurance of hygiene and quality of meat‐based products, fish and fish products; inspection of meat‐based, seafood, fish and fish products; regulation aspects; foodborne diseases and intoxications; environmental issues related to food production and waste management.

17BA. Production and assurance of hygiene and quality of meat‐based products

1st hour Production technologies of meat‐based products (gyros, patties, etc.) [Ι.Α.] 2nd hour Production technology of fresh and semi‐dry sausages [Ι.Α.] 3rd‐4th hour Production technology of cooked sausages and cooked ham [Ι.Α.] 5th hour Production technology of dry sausages and dry ham. [Ι.Α.] 6th‐8th hour Safety, preservation, inspection and spoilage of sausages and other meat‐based products. Regulatory aspects [Ν.S.] 9th‐10th hour Chilled and frozen foods. Spoilage, inspection, regulatory aspects [E.P.]

18BB. Production and assurance of hygiene and quality of meat‐based products (practicals)

2 hours Inspection of canned foods [Ε.Ι.] 2 hours Identification of meat spoilage [E.P.] 3 hours Classification of meat‐based products. Manufacture of cooked sausages. [Ι.Α., Μ.P., Α.P., F.Z.] 3 hours Exercise in a meat‐based products production unit [I.A., Μ.P., Α.P., F.Z.] 3 hours Inspection of sausage products [Ν.S.]

109

19BC. Hygiene and quality assurance of fish and fish products

11th‐12th hour Preservation and processing methods of fish [Μ.P.] 13th‐14th hour Products and processing technologies of fish of low value [Μ.P.] 15th hour Hygiene of fresh, chilled, frozen and processed fish [Αb.Αm.] 16th‐18th hour The seafood industry. Handling of raw material and processing of chilled, frozen and other processed seafood. Fish meat‐based products. Production, hygiene, preservation, inspection, product deterioration and spoilage, regulatory aspects. Critical control points in inspection and HACCP systems application. Seafood and public health [Αb.Αm.]

Hygiene and quality assurance of fish and fish products (practicals) [Αb.Αm., Μ.P.]

3 hours Identification of seafood 2 hours Inspection of seafood at market level 2 hours Evaluation of freshness and quality of fish 3 hours Training visit in fish processing industrial unit

20BD. Foodborne diseases

19th hour Bacterial foodborne diseases. Foodborne intoxications: staphylococcal intoxication, botulism, Clostridium perfringens gastroenteritis, Bacillus cereus gastroenteritis [Ε.Ι.] 20th hour Foodborne infections: Salmonellosis by Salmonella enterica, Pathogenic Escherichia coli, gastroenteritis due to Enterohaemorrhagic E. coli (EHEC), Shigellosis by Shigella Species [Ε.Ι.] 21st hour Foodborne infections: Campylobacteriosis by Campylobacter Species., Listeriosis by Listeria monocytogenes, Yersiniosis by Yersinia enterocolytica, Vibrio paraemolyticus gastroenteritis [Ε.Ι.] 22nd hour Viruses, fungi and parasites associated with foodborne diseases. Marine biotoxins associated with fish and shellfish poisoning [Ε.Ι.] 23rd‐24th hour Procedure to investigate foodborne diseases [Ε.Ι.] 25rd‐26th hour Residues of veterinary drugs and other chemical contaminants in foods of animal origin. Acceptable Daily Intake (ADI), Maximum Residue Limit (MRL), Withdrawal Period (WP) [Ε.P.]

110 27th‐28th hour Human health implications of chemical contaminants in foods of animal origin (veterinary drugs, heavy metals, pesticides, PCBs, dioxins, etc). Prevention. Regulatory aspects (national, EU, CAC) [Ε.P.]

36BE. Environmental issues related to food production (including waste management)

29th‐30th hour Environmental issues related to food production (including waste management) [A.K., X.K.]

Grade Distribution of Practical Examination Slaughterhouses (7th & 8th semester) 80% Laboratories 20%

Final Grade Theory 60% Practicals 40%

111 8th (ΙΙΙ) Module ‐ 7th Semester

117BClinical Sciences ΙΙΙ

This module covers the alimentary system and peritonea; cavity diseases, the pathophysiology of reproduction of the male genital system, obstetrics and pathology of reproduction and pathological anatomy of female livestock and companion animals. Learning objectives Alimentary system: to understand the pathologic and pathophysiologic basis, clinical manifestations, diagnostic approach and the medical and surgical treatment of the diseases affecting the gastrointestinal system (including liver and pancreas) and to become familiar with the basic principles of the gastrointestinal system surgery in the dog and cat. Reproductive system: to obtain working knowledge on the pathophysiology of reproduction and the clinical manifestations, medical and surgical treatments of the male genital system and to understand the basic principles of obstetrics, pathology of reproduction and pathological anatomy of female livestock animals; to become familiar with the modern methods of insemination and reproduction management of animals.

1st Section Diseases of oral cavity, salivary glands, stomach (ruminant forestomach) small and large intestine

2nd Section Hernias. Peritoneal cavity. Diseases of esophagus, liver and pangreas. Pathophysiology of reproduction and pathology of male genital track

3rd Section Obstetrics‐Pathology of Reproduction and Pathological Anatomy of Female Productive Animals and Horse Modern Methods of Insemination and Management of Reproduction of animals

21BPathology 1st hour Oral Cavity. Developmental anomalies of the oral cavity. Teeth: anomalies of tooth development, degenerative diseases, inflammatory lesions, dental neoplasms. Circulatory disturbances, foreign bodies, stomatitides, neoplasms of the oral cavity. Conditions affecting the tonsils [P.L.]

112 2nd hour Salivary glands: foreign bodies, sialoliths, infammatory diseases, neoplasms. Oesophagus: oesophagitis, neoplasms [P.L.] 3rd hour Ruminant forestomach. Foreign bodies of the rumen. Traumatic reticulitis. Inflammatory diseases of the forestomach (bacterial, mycotic, parasitic). Neoplasms of the forestomach [T.P.] 4th hour Stomach. Gastric dilation and volvulus. Abomasal displacement. Abomasal ulcers. Circulatory disturbances. Gastritis (acute, chronic, eosinophilic, bacterial, mycotic). Gastric neoplasms [T.P.] 5th hour Intestine. Congenital and acquired abnormalities, circulatory disturbances, inflammation of the small intestine (acute and chronic enteritis), inflammation of the large intestine (typhlocolitis), amyloidosis [T.P.] 6th‐7th hour Viral diseases affecting the alimentary system: foot‐and‐ mouth disease, vesicular stomatitides, BVD‐MD, rinderpest, malignant catarrhal fever. Enterititides due to herpesviruses, adenoviruses, coronaviruses, rotaviruses and parvoviruses [T.P.] 8th‐9th hour Bacterial diseases affecting the alimentary system. Collibacillosis (swine, bovine). Salmonellosis of ruminants, pigs, horses, carnivores. Enterotoxaemia of lambs, goat kids, calves, foals. Enterotoxaemia of sheep, goats, bovines, piglets; pulpy kidney disease. Peracute haemorrhagic gastroenteritis of dogs. Paratuberculosis of ruminants. Chlamydiosis, fungal diseases including candidiasis and histoplasmosis, mucoid enteropathy, Tyzzer’s disease, enteritides due to Yersinia and Campylobacter [T.P.] 10th hour Parasitic diseases affecting the alimentary system. Enteritides due to protozoa, nematodes, cestodes, trematodes. Intestinal neoplasms [T.P.]

22BDiagnostic approach (methods of examination and clinical pathology)

11th hour Diagnostic approach of oral cavity and esophageal disorders (clinical signs, hematological and biochemical abnormalities, endoscopy findings, special diagnostic procedures) [T.R.] 12th hour Diagnostic approach of gastric disorders (clinical signs, hematological and biochemical abnormalities, endoscopy findings, special diagnostic procedures) [T.R.] 13th hour Diagnostic approach of intestinal disorders (clinical signs, hematological and biochemical abnormalities, endoscopy findings, special diagnostic procedures) [T.R.]

113 23BCanine and Feline Gastroenterology 14th hour Stomatitis, pharyngitis, tonsillitis (infectious agents, secondary stomatitis). Chronic stomatitis – gingivitis of the cat (lymphocytic‐plasmacytic stomatitis) [T.R.] 15th hour Oral cavity neoplasms (epulis, papillomatosis, TVT, melanoma, fibrosarcoma, squamous cell carcinoma), sialadenitis. Oropharyngeal dysphagia [T.R.] 16th hour Diseases of the esophagus. “Morphological” disorders (esophageal foreign body, esophagitis, gastroesophageal reflux, esophageal stenosis, vascular ring anomalies), spirocercosis [T.R.] 17th hour Esophageal motility disorders (megaesophagus) [T.R.] 18th hour Definition of the “gastric mucosal barrier”. Acute gastritis [T.R.] 19th hour Chronic gastric disorders (lymphocytic‐plasmacytic and eosinophilic gastritis). Other types of gastritis (parasitic, duodenal reflux gastritis, Helicobacter spp gastritis) [T.R.] 20th hour Gastric ulcers. Retention of gastric contents due to morphologic or motility (gastric atony) disorders. Gastric neoplasia [T.R.] 21st hour Acute enteritis (diarrhea) of various etiology (nutritional, drug‐induced, toxic, bacterial, parasitic or fungal) [T.R.] 22nd hour Viral enteritis‐diarrhea. Parvo‐ and Coronavirus enteritis in dogs. Panleukopenia virus enteritis in cats. Acute hemorrhagic gastroenteritis syndrome [T.R.] 23rd hour Specific and supportive treatment of acute enteritis – diarrhea [T.R.] 24nd hour Chronic inflammatory small bowel disease. Small intestinal bacterial overgrowth. Villus atrophy. Lymphangiectasia. Adverse reactions to food [T.R.] 25th hour Chronic inflammatory large bowel disease (chronic colitis). Infectious colitis. Other causes of colitis [T.R.] 26th hour Constipation and obstipation. Megacolon in the cat. Diseases of the anus [T.R.]

24BSurgery of the gastrointestinal system in the dog and cat

27th hour Surgery of the oral cavity, pharynx and salivary glands. Diagnosis and surgical treatment of oral neoplasms. Feline nasophryngeal polyps. Tonsillectomy. Diagnosis and surgical treatment of mucoceles and salivary neoplasms [L.P.] 28th–29th hour Dentistry: Periodontology. Extraction [S.P.] 30th hour Dentistry: Surgery of the oral cavity [S.P.]

114 2nd Section 1‐2nd hour Hernias. Inroduction to hernias. Umbilical hernia, inguinal hernia, perineal hernia, ventral hernia and diaphragmatic hernia [L.P.] 3rd hour Esophagus. Principles of esophageal surgery. Esophagotomy and esophageal resection and anastomosis. Vascular rings, diverticula, fistulas, neoplasms, hiatal hernia and gastroesophageal intussusception. Esophagostomy. Surgical treatment of cricopharyngeal achalasia [L.P.] 4th–5th hour Stomach. Principles of gastric surgery. Gastrotomy. Gastric dilatation ‐volvulus. Surgical treatment of delayed gastric emptying (pyloromyotomy and pyloroplasty). Surgery of the gastric neoplasms. Gastrectomy and gastrostomy [L.P.] 6th‐7th hour Small intestine. Principles of small intestinal surgery. Intestinal obstruction (foreign bodies, intussusception, mesenteric torsion, neoplasms). Intestinal biopsy, enterotomy, intestinal resection and anastomosis. Jejunostomy [L.P.] 8th–9th hour Large intestine, rectum and anus. Principles of surgery of the large intestine. Megacolon, neoplasms of the large intestine, intestinal prolapse, perineal neoplasms, atresia ani, colotomy and colostomy. Surgery of the anal sacs [L.P.]

25BRadiographic interpretation of the diseases of the Alimentary Tract 10th hour Bocal vavity(neoplasia, dental abnormalities).Pharynx (abscess, foreign bodies, neoplasia). Esophagus (atresia, foreign bodies, megaesophagus, local esophageal dilation, esophageal stenosis, esophageal rupture, gastroesophageal intussusception). Stomach (gastritis and gastric ulcers, gastric dilation, acute gastric dilation and volvulus). Ultrasonographic interpretation of the diseases [P.P.] 11th hour Small intestine(enteritis, foreign bodies, mechanical and paralytic ileus, intussusception,neoplasia). Large intestine (obstipation, megacolon, large intestineatresia). Ultrasonographic interpretation of the diseases [P.M.]

26BInternal Medicine and Surgery of the Equine Alimentary System 12th hour Clinical examination Diseases of the stomach‐duodenum (gastric ulcers, duodenitis, proximal jejunitis) [N.D.] 13th hour Spasmodic colic, thromboembolic colic [N.D.] 14th hour Salmonellosis, large colon impaction, ileal impaction and obstruction, tympany of the caecum, peritonitis [N.D.] 15th hour Problems involving the teeth, Esophageal obstruction [N.D.]

115 16th hour Surgical colic, Enterotomy techniques, small and large colon obstructions and strangulations, hernias, inguinal herniorrhaphy [N.D.]

27BCattle diseases of digestive system 17th hour Stomatitis, pharyngitis, pharyngeal paralysis, oesophagitis, rumen immotility [H.K.] 18th hour Rumen alkalosis, rumen fluid disturbances, rumen acidosis [H.K.] 19th hour Acute tympany, chronic relapsing tympany, traumatic reticuloperitonitis, omasal immobility [H.K.] 20th hour Hoflund syndrome, abomasistis, abomasal ulcer [H.K.] 21th hour Abomasal displacement [H.K.] 22th‐26th hour Enteritis: a) non transmitted, b) transmitted: colibacillosis, salmonellosis, enterotoxaemia, paratuberculosis, winter dysentery, campylobacter, rotavirus, coronavirus, BVD‐ MD, cryptosporidiosis, coccidiosis, nematodiosis, infectious keratoconjuctivitis, malignant catarrhal fever, rinderpest, actinobacillosis, actinomycosis, FMD, pustular stomatitis [Ni.P.]

197BSurgery of cattle digestive system 27th‐29th hour Oesophageal obstruction, laparotomy, abomasal displacement, Caecal dilatation and torsion, peritonitis, umbilical hernia and Ompalitis, anal atresia, rectal prolapse [H.K.]

198BSmall Ruminant Diseases of digestive system 30th hour Acute‐chronic rumen acidosis [Ν.G.] 31th‐32th hour Clostridial infections (enterotoxaemias, necrotic hepatitis, gas gangrene, blackleg, tetanus) [Ν.G.] 33th‐34th hour Adult diarrhoea, indigestion, liver disease, paratuberculosis, gastrointestinal parasitosis [Ν.G.] 35th‐39th hour Neonatal loss (moribud, hypothermia, diarrhoea, watery mouth, necrobacillosis, cysticercosis, cryptosporidiosis. [Ν.G.] 40th hour Lamb and kid>15 days old losses (coccidiosis, streptococcal encephalitis, acute coenurosis, muscular dystrophy, CCN etc) [Ν.G.]

199BSwine diseases of digestive system 41st‐44th hour Enteric colibacillosis. Postweaning diarrhoea syndrome. Oedema disease, Clostridial enteritis. Swine dysentery. Porcine proliferative enteropathy. Porcine epidemic diarrhoea. Swine hepatitis E, Trasmissible gastroenteritis. Rotavirus and Enterovirus infections. Coccidiosis. Cryptosporidiasis. Infection by Hyostrongylus rubidus, Strongyloides ransomi, Ascaris suum, Trichuris suis, Oesophagostomum spp. Infection by Candida albicans. Non infectious diarrhoea of lactating and weaning piglers. Coprostasis, constipation. Gastric ulcers. Rectal prolapse.

116 Foot and mouth disease, swine vesicular disease, vesicular exanthema of swine, vesicular stomatitis [Ε.Τz.]

Liver ‐Pancreas

200BPathology 45th hour Liver. Post mortem examination of the liver. Developmental abnormalities, displacement, torsion, rupture of the liver. Cholostasis. Response of the liver to injury. Pigment accumulations. [P.L.] 46th hour Liver degeneration. Amyloidosis. Vascular and haemodynamic disturbances. Liver necrosis. Hepatitis. Diseases of viral aetiology (canine infectious hepatitis, Rift valley fever, Wesselsbron’s disease), bacterial aetiology (abscesses, necrotic hepatitis, crostridial hepatitis) or parasitic aetiology (parasitic hepatitis) affecting the liver [P.L.] 47th hour Dietary diseases affecting the liver. Toxicoses. Neoplasms of the liver and gallbladder [P.L.] 48th hour Pancreas (exocrine). Post mortem examination of the pancreas. Congenital anomalies, atrophy, hypoplasia, necrosis, inflammation, parasitic diseases of the pancreas, neoplasms of the pancreas. Peritoneal cavity. Congenital anomalies, abnormal peritoneal contents, fat necrosis, peritonitis. parasitic infections, neoplasms [P.L.]

201BDiagnostic approach (methods of examination and clinical pathology) 49th hour Diagnostic approach of liver diseases (clinical, hematological and biochemical findings, special diagnostic procedures) [T.R.] 50th hour Diagnostic approach of exocrine pancreatic diseases (clinical, hematological and biochemical findings, special diagnostic procedures) [T.R.]

202BDiseases of the Liver and Exocrine Pancreas of Dogs and Cats 51st hour Infectious liver diseases of dogs and cats. Non‐ inflammatory liver diseases (hepatic lipidosis and amyloidosis) [T.R.] 52nd hour Chronic inflammatory liver diseases (chronic hepatitis, chronic active hepatitis, toxic and drug‐induced liver disease, breed‐associated hepatopathies) [T.R.] 53rd hour Diseases of the gallbladder and biliary tract (canine and feline cholangiohepatitis) [T.R.] 54th hour Hepatic insufficiency and associated clinical syndromes (ascites, portal hypertension, hepatic encephalopathy, other) [T.R.] 55th hour Exocrine pancreatic insufficiency [T.R.] 56th hour Acute pancreatitis in dogs and cats [T.R.]

117 203BSurgery of the liver and pancreas in the dog and cat 57th hour Surgery of the liver and pancreas. Hepatic biopsy. Surgery of the portosystemic shunts. Hepatic lobectomy. Pancreatic biopsy and pancreatectomy [L.P.]

204BRadiographic interpretation of the disorders of the Liver, Pancreas, Peritoneal Cavity, Hernias and Male Genital System 58th hour Radiographicinterpretation of the hepaticdisorders (hepatomegaly, microhepatica, neoplasia, chololithiasis and other diseases of the bile duct system). Radiographicinterpretation of thepancreatic disorders (pancreatitis, neoplasia). Ascites. Peritonitis. Peritoneal masses (abscessess, neoplasia, mesenteric lymph nodes). Hernias (diaphragmatic hernias, hiatal hernias, inguinal and perineal hernias). Radiographic interpretation of thetesticulardisorders (orhitis, neoplasia,torsion, cryptorchid testis). Ultrasonographic interpretation of thediseases[P.M.]

205BEquine Liver Diseases 59th hour Liver diseases (hyperlipidemia, Theiler’s disease, chronic active hepatitis, cholelithiasis), hepatic failure [N.D.]

206BCattle liver diseases 60th‐61th hour Acute hepatitis, chronic hepatitis, fatty degeneration, ketosis (cause, symptoms, diagnosis, treatment) [Ch.K.]

37BPathophysiology of reproduction and pathology of the male genital system 62nd hour Penis–Testis. Developmental abnormalities, inflamations and neoplasms of the penis and preputium. Developmental abnormalities and degeneration of the testis. Epididymitis [D.Ps.] 63rd hour Circulatory disturbances. Orchitides and inflammatory conditions of the spermatic cord and accessory genital glands. Testicular neoplasms [D.Ps] 64th hour Control of operation of genital system of male animals causing disturbances of fertility. Control of mating ability [I.T.] 65th hour Methodology of collection of sperm in the various species of animals. Methods of examination and estimate of quality of sperm [I.T.] 66th hour Morphological abnormalities of spermatozoa and correlation with pathological situations of genital system [I.T.] 67th hour Pathological situations of genital system of male: Situations that lead to inability of mating [I.T.] 68th hour Pathological situations of genital system of male: Rupture of corpus cavernosum, Phallocampsis, remaining frenulum preputii, premature erection [I.T.]

118 69th hour Pathological situations of genital system of male: Damage of prepuce, valanoposthitis, Phimosis, Paraphimosis, strangulation and necrosis of penis, penis neoplasms [I.T.] 70th hour Pathological situations of genital system of male: Pathological situations of testicles and epididymis, cryptorchidism, testicular degeneration, orchitis, epididymitis [I.T.] 71st hour Pathological situations of genital system of male: Hypoplasia and neoplasms of testicles, pathological situations of complementary genital glands [I.T.] 72nd hour Surgery of the male genital tract in the dog and cat. Penile surgery, preputial surgery and testicular surgery [L.P.] 73th hour Castration, cryptorchidectomy [N.D.]

3rd Section

38BObstetrics‐Pathology of Reproduction and Pathological Anatomy of Female Productive Animals and Horse 1st hour Ovary. Abnormalities of growth of ovary. Hemorrhage of the ovary. Ovarian cysts–Cystic degeneration of ovary in the cow. Neoplasms of ovary [D.Ps.] 2nd hour Uterus. Hydrosalpinx (mucus in the oviduct)– Salpigitis (inflammation of oviduct)–Pyosalpinx (puss in the oviduct). Endometritis–Metritis–Perimetritis. Pyometra. Special inflamations of uterus. Pathological situations of pregnant uterus. Abortions in the cattle and in small ruminants [D.Ps.] 3rd hour Symptoms and detection of estrus, more suitable time of insemination at animal species [C.Bo.] 4th hour Irregular growth of fetus. Hermaphroditism (freemartinism). Embrionic deaths in the various species of animals. Consequences in the operation of genital system [C.Bo.] 5th‐6th hour Pregnancy diagnosis in the animals. Evaluation of the stage of pregnancy [C.Bo.] 7th hour Pathological situations of embrionic membranes and liquids. Placental Abnormalities, Mole, Drops of the fetal mebrane (Hydropic) embrionic membranes, placuntitis, abnormalities of the umbilical cord [E.K.] 8th hour Pathological situations at the implantation and growth of foetuses. superfecundation, superferation, gestation of excessive number of foetuses, extrauterine pregnancy, fetal anasarca, embrionic death (mummification, fetal maceration, emphysema) [Ε.K.] 9th hour Abortion. Differential diagnosis and prevention of contagious and not contagious abortions [E.K.] 10th hour Abortion. Indications and methodology. Extension of duration of gestation [E.K.]

119 11th–12th hour Pathological situations of maternal organism during gestation. pseudopregnacy, incomplete convergence of cervix, estrus during gestation, presence of abnormal discharge. Rupture of uterus, Hernia graviditatis, edema of pregnancy, premature throes. Vagina prolapse [E.K.] 13th hour Parturition (mechanism, indications of imminent delivery, symptoms, preparation of animals, stages of parturition) [C.Bo.] 14th hour Specificity of childbirth in the various species of animals. Benefit of help in expected animals [C.Bo.] 15th hour Periparturient control and care of newborn [C.Bo.] 16th hour Stage of afterbirth. Removal of embrionic membranes. Physiologic progress of post partum period. Prevention of uterus contamination [C.Bo.] 17th‐19th hour Dystocia and types of dystocia in the various species of animals (maternal and embrionic) [E.K.] 20th–21st hour Caesarean section. Indications, contraindications, callousness, technique, treatment after the surgical operation, complications (cow and other species of animals) [C.Br.] 22nd hour Fetotomy. Indications, contraindications, technique, complications [E.K.] 23rd hour Contusions at the parturition. Bleeding, bruises of genital tract and local regions, damage of sciatic mesh) [C.Br.] 24th hour Corrective interventions. Rupture of uterus and cervix, prolapsed urinary bladder, prolapse of vaginal fat. Post partum pododermatitis, downer cow, tetanus. Post partum hemoglobinuria, puerperal malignant edema. Post partum prolapse of the uterus. Amputation of prolapsed uterus [C.Br.] 25th hour Retained placenta in the cow and remaining animals (reasons, diagnosis and confrontation) [C.Br.] 26th‐27th hour Post partum pathological situations and their confrontation. Milk fever, Tetany [C.Br.] 28th–38th hour Post partum diseases in the cow. Metritis, endometritis, pyometra, vulvovaginitis. Post partum anoestrus. Infertility; Reasons and confrontation. [G.T.] 39th hour Cystic ovaries [C.Bo.] 40‐43rd hour Main diseases and pathological situations of reproductive system of small ruminants [E.K.] 44th–45th hour Disturbances of fertility of horses from contagious and not contagious reasons. Special infections (Coithal exanthema genital, contagious metritis of horses, equine viral arteritis, durine). Embrionic death, abortions [I.T.] 46th–48th hour Main diseases and pathological situations of reproductive system of female pig: Leptospirosis, brucellosis, parvo, chlamydiosis, toxoplasmosis [E.Tz.]

120 39BModern Methods of Insemination and Management of Reproduction of animals 49th hour Methods of treatment and maintainance fresh and frozen sperm of bull. Methodology of insemination in the cow with fresh and with frozen sperm [C.Bo.] 50th hour Methods of treatment and maintainance fresh and frozen sperm of stallion. Methodology of inseminaion in the horses with fresh and with frozen sperm [I.T.] 51st hour Methods of treatment and maintainance fresh and frozen sperm of small ruminants. Methodology of insemination in the ewe and the goat with fresh and with frozen sperm [I.T.] 52nd hour Methods of treatment and maintainance fresh and frozen sperm of boar. Methodology of insemination in the sow with fresh and with frozen sperm [I.T.] 53rd hour Methods of treatment and maintainance fresh and frozen sperm of dog. Methodology of insemination in the female dog with fresh and with frozen sperm [C.Bo.] 54th hour Methodology of treatment and maintainance fresh and frozen sperm and insemination in the rabbit and birds [I.T.] 55th hour Techniques of embryo transfer in the cattle. Application [C.Bo.] 56th hour Techniques of embryo transfer in the small ruminants and in the other species of animals. Applications [C.Bo.] 57th hour Programs of estrus synchronization in dairy cows [C.Bo.] 58th hour Programs of estrus synchronization in small ruminants [C.Bo.] 59th hour Control and management of fertility in dairy cow’s farms [C.Br.] 60th hour Problems and hormonal interventions at the beginning of post partum ovarian activity [C.Br.] 61st‐62nd hour Follow‐up and management of health of udder at the farm level. Special interventions of re‐establishment of lesions of udder and teats. Surgical and endoscopical techniques [E.K.] 63rd‐64th hour Application of programs of reproductive management in pig farms [I.T.]

Practical training in the Clinics (rotation) 3 In the Clinic of Companion Animals and in the Large Animal Clinic: 39 hours/student

121

COURSE 8th Semester Hours/semester

92BL P ECTS

7th (IV) Practical training in slaughterhouses 18 1.0

Clinical Sciences IV (including Diseases, Surgery, Diagnostic Imaging and Pathology of the Integument, the Endocrine, Nervous and Musculoskeletal System, Exotic 8th (IV) Animal Medicine and Surgery, Anesthesiology and 206 87 29.5 Intensive Care, Avian Medicine)

28BTotal 206 105 30.5

Elective topics 1. Diagnostic Imaging (5 hours of lectures, 25 hours practicals) 2. Husbantry and diseases of farm animals: Small ruminants (15 hours lectures, 40 hours practicals) 3. Food Biotechnology (9 hours lectures, 6 hours practicals) 4. Food Microbiology (21 hours lectures, 24 hours practicals) 5. Food Toxicology (12 hours lectures, 6 hours practicals) 6. Hygiene and technology of dairy products (24 hours lectures, 24 hours practicals)

Instructors of the 8th Semester modules

Amin Abrahim Ab.Am. Anagnostou Tilemahos T.A. Brellou Georgia G.Br. Diakakis Nikolaos N.D. Georgopoulou Ioanna I.G. Giadinis Nektarios N.G. Iosifidou Eleni E.I. Kaldrymidou Eleni Ε.Κ. Karagiannopoulou Maria Ma.K. Karatzias Harilaos H.K.

122 Kazakos Georgios G.K. Koidis Pavlos P.K. Komnenou Anastasia An.K. Koutinas Alexandros Al.K. Kritsepi Maria M.K. Mylonakis Mathaios M.M. Panousis Nikolaos Ni.P. Papadimitriou Serafim S.P. Papadopoulou Paraskevi P.P. Papaioannou Nikolaos Ν.P. Papapanagiotou Elias E.P. Papazoglou Lysimahos L.P. Patsikas Michail P.M. Polizopoulou Zoe Z.P. Prassinos Nikitas N.Pr. Psalla Dimitra D.Ps. Raptopoulos Dimitrios D.R. Savvas Ioannis I.S. Sergelidis Daniil D.S. Soubasis Nektarios N.S. Soultos Nikolaos N.S. Tzika Eleni E.Tz.

123 7th (ΙV) Module ‐ 8th Semester

118BFood Sciences ΙΙΙ

18 hours Training in meat inspection in slaughterhouses [P.K., E.I., Am.Ab., N.S., E.P., D.S.]

8th (ΙV) Module ‐ 8th Semester

119BClinical Sciences ΙV

This module covers the dermatology, endocrinology and sensory organs, anesthe‐ siology and intensive care medicine, neurology and musculoskeletal disorders of livestock and companion animals. It also covers avian, exotic and wildlife medicine.

93BLearning objectives Dermatology, endocrinology and sensory organs: to understand the aetiopatho‐ genesis, the pathologic basis, clinical manifestations, diagnostic approach and the medical and surgical treatment of the diseases affecting the skin, selected sensory organs (ears and eyes) and the endocrine glands of companion and livestock animals. Nervous and musculoskeletal system: to understand the pathophysiologic basis, diagnostic approach, clinical manifestations and medical and surgical treatment of neurologic diseases, myopathies, orthopedic and metabolic bone disorders; to become familiar with basic principles of neurosurgery and rehabilitation medicine. Anesthesiology and intensive care medicine: to understand the basic principles of anesthesia and become familiar with local anesthesia and analgesia techniques, the classes and proper use of sedative and general anesthesia drugs; to understand the rationale of disease‐specific anesthetic protocols; to become familiar with the equipment and the readiness preparations in an intensive care unit. Avian, exotic and wildlife medicine: to become familiar with the anatomy, physiology, general husbandry, feeding techniques, handling, clinical examination, diagnostic sampling techniques, species‐specific anesthetic procedures, clinic‐ pathological evaluation, imaging techniques, therapeutics and euthanasia methods of common exotic and wildlife species. To become familiar with the aetiopatho‐ genesis, clinical manifestations, diagnostic approach and management of common infectious, parasitic and metabolic diseases that affect poultry Necropsy Students will acquire:

124 1. Knowledge of the pathogenesis and pathology of clinically important /common animal diseases to provide a foundation for their clinical studies. 2. Further enhancement of their observational, descriptive and interpretive skills in problem‐solving exercises using clinico‐pathological material and laboratory data. 3. Further reinforcement of the principles of disease diagnosis and an appreciation of the value of further investigation/research.

1st Section Anesthesia, Nervous System 2nd Section Dermatology, Sensory Organs, Endocrine System 3rd Section Musculoskeletal System 4th Section Avian Medicine, Exotic and Wildlife Medicine, Miscellaneous

The integument

40BPathology (aetiopathogenesis, microscopic lesions, differential diagnosis) 1st hour General principles. Nomenclature of histopathologic lesions of the skin. Bacterial dermatitides (granulomatous and non‐granulomatous). Viral and mycotic dermatitides [N.P.] 2nd hour Dermatitides due to protozoa and arthropods (flies, lice, fleas, mites; mange) [N.P.] 3rd hour Hypersensitivity reactions of the skin: urticaria, atopy, hypersensitivity dermatitis due to food allergy, allergic contact dermatitis, flea bite hypersensitivity, pemphigus, lupus erythematosus) [N.P.] 4th hour Keratinisation disturbances (seborrhea, acne). Pigmentation disorders. Disorders due to physical or chemical injury, or radiation. Dermatopathies related to nutrition [N.P.] 5th hour Congenital dermatopathies. Various disorders (eosinophilic granuloma, collagenolytic granuloma, amyloidosis, etc) [N.P.] 6th hour Cutaneous neoplasms [N.P.]

41BAn introduction to Veterinary Dermatology 7th hour An introduction to veterinary dermatology.Diagnostic approach to skin diseases: history, haircoat examination and its type of lesions. Clinical evaluation of the skin: primary and secondary skin lesions, appearance and distribution of skin lesions, pruritus [Al.K.]

125 42BCanine and feline Dermatology 8th‐9th hour Bacterial pyodermas, Deep and superficial pyodermas in the dog. Feline bacterial pyoderma. Management of pyodermas [Al.K.] 10th hour Dermatophytosis and other mycoses [Al.K.] 11th hour Canine demodicosis [Al.K.] 12th hour Sarcoptic acariosis in the dog. Otodectic acariosis in the dog and cat [Al.K.] 13th hour Canine leishmaniosis [Al.K.] 14th hour Urticaria ‐ Angioedema and Atopic dermatitis in the dog [Al.K.] 15th hour Food allergy ‐ intolerance ‐ Flea allergic dermatitis [Al.K.] 16th hour Treatment and prevention of ectoparasitic skin diseases [Al.K.] 17th hour Pemphigus foliaceous ‐ Photosensitive and localized cutaneous lupus erythematosus [Al.K.] 18th hour Drug eruption ‐ Cutaneous vasculitis [Al.K.] 19th hour Canine seborrhea and antiseborrheic therapy [Al.K.] 20th hour Irritative contact dermatitis ‐ Pyotraumatic dermatitis, skin fold dermatitis. Canine calluses [Al.K.] 21st hour Lick acral dermatitis in the dog. Juvenile canine pyoderma (puppy strangles) [Al.K.] 22nd‐23rd hour Hereditary and congenital skin diseases. Cutaneous neoplasms [Al.K.]

43BSurgical management of selected skin disorders 24th hour Surgical treatment of specific skin disorders. Foreign body sinus. Interdigital cysts. Elbow hygroma. Mammary neoplasms in the dog and cat [Ma.K.]

Sensory organs

44BPathology 25th hour Ear. Ear malformations, otitides and other inflammatory conditions; neoplasms. Eye. Malformations, post mortem changes [E.K.] 26th hour Inflammatory disorders, degenerative disorders and malformations of the cornea, the uvea, the lens and the retina. Malformation and inflammation of the optic nerve. Opthalmic neoplasms [E.K.]

45BOpthalmology 27th hour Eye Clinical Examination. Eye Lids, Conjunctiva, and Lacrimal System [An.K.] 28th hour Cornea, Sclera and Uvea [An.K.] 29th hour Retina and Vitreous. Glaucoma and Cataract [An.K.] 30th hour Globe. Ocular therapeutics [An.K.]

46BSurgery of the pinna and the ear canal 31st–32nd hour Surgery of the ear in the dog and cat. Aural hematoma, neoplasms and trauma of the pinna. Surgery of the

126 external and middle ear (lateral wall resection, vertical canal ablation, total canal ablation and lateral bulla osteotomy, ventral bulla osteotomy). Neoplasms of the external ear canal. Ear canal polyps in the cat [L.P.]

47BEquine Dermatology 33rd‐34th hour Dermatophilosis, Bacterial folliculitis – furunculosis. Dermatophytosis. Ventral middle line dermatitis (syndrome). Insect bite dermatitis. Urticaria. Cullicoides allergic dermatitis. Drug eruption. Pemphigus folliaceus. Eosinophilic granuloma. Seborrhea. Photodermatitis. Pastery dermatitis syndrome. Sarcoids. Melanomas [Al.Κ.]

48BCattle skin diseases 35th‐36th hour Papilomatosis, ringworm, dermatophilosis, mange (sarcoptic, psoroptic, chorioptic, demodectic), lice, ticks, photosensitization, hypodermosis, stephanofilariosis, neoplasms, vascular edema, contact dermatitis, burns, frostbite [H.K.]

49BSmall ruminant skin diseases 37th‐40th hour Staphylococcal dermatitis, pseudotuberculosis, abscess, orf, photosensitization, neoplasms, pox, edema disease, mange, ringworm, dermatophilosis, other ectoparasites (lice, ticks), infectious foot rot, interdigital dermatitis, FMD, Bluetongue [Ni.P.]

50BSwine skin diseases 41st‐42nd hour Staphylococcal dermatitis. Exudative epidermitis. Swine pox. Porcine dermatitis nephropathy syndrome. Pityriasis rosea. Dermatophilus congolensis infection. Ringworm. Dermatosis vegetans. Parakeratosis. Demodectic and sarcoptic mange. External parasites (fleas and flies). Sunburn. Photosensitization [Ε.Τz.]

Endocrine system

51BPathology 1st‐2nd hour Diseases associated with neoplasms of the adenohypophysis. Hyperthyroidism. Hyperplasia of thyroid follicular cells (“goiter”). Neoplasms of the thyroid gland. Hypoparathyroidism. Hyperparathyroidism. Hypoadreno‐ corticism (Addison’s disease). Hyperadrenocorticism (Cushing’s disease). Diabetes mellitus. Neoplasms of the carotid and aortic bodies [D.Ps.]

52BDiagnostic approach 3rd hour Special diagnostic tests [N.S.]

53BClinical Endocrinology of the Dog and Cat 4th hour Acquired hypothyroidism in the dog [N.S.] 5th hour Hyperadrenocorticism (Cushing’s disease) in the dog [N.S.]

127 6th ‐7th hour Canine diabetes mellitus [N.S.] 8th hour Feline diabetes mellitus [N.S.] 9th hour Obesity [N.S.] 10th hour Hypoglycemia in the dog [N.S.] 11th hour Hypercalcemia in the dog [N.S.]

54BSurgery of the endocrine glands in the dog and cat 12th hour Surgery of the thyroid gland and adrenals [L.P.]

55BEquine Endocrinology 13th hour Hypophyseal adenomas (Cushing’s disease), hyperlipid‐ emia [N.D.]

The Nervous System

56BPathology 1st hour Central nervous system. Post mortem changes. Malformations. Encephaloclastic defects. Porencephaly and hydranencephaly. Hydromyelia. Syringomyelia. Neurogenic myopathies. Hereditary enzyme disorders; lipidoses. Metabolic disorders, pigment accumulations. Inflammation of the meninges and choroid plexus. Nervous tissue injury; degenerative diseases [E.K.] 2nd hour Atrophies. Toxicoses. Lesions due to endogenous toxins. Nervous system lesions due to vitamin and mineral deficiencies [E.K.] 3rd hour Circulatory disturbances. Inflammatory diseases: pathogenesis and pathology of the main viral diseases affecting the nervous system eg rabies, Aujeszky disease, canine distemper etc [E.K.] 4th hour Encephalitides and encephalopathies caused by microbes, parasites, fungi and unidentified agents (eg listeriosis, cryptococcosis, toxoplasmosis, ovine spongiform encephalopathy, bovine spongiform encephalopathy etc) [E.K.] 5th hour Peripheral nervous system. Neuronal degeneration. Neuropathies. Neurititides. Neoplasms of the peripheral nervous system. Neoplasms of the central nervous system [E.K.]

57BDiagnostic approach 6th‐7th hour The neurological examination. Neuroanatomical localization of lesions in the nervous system. Special diagnostic tests [Z.P.]

58BClinical Neurology of Dogs and Cats 8th hour Canine distemper, toxoplasmosis and neosporosis [Z.P.] 9th hour Rabies and cryptococcosis [Z.P.]

128 10th hour Steroid‐responsive meningitis, granulomatous meningo‐ encephalitis (GME) in the dog. Neurotoxicoses (lead, ivermectin, organophosphates and carbamates) [Z.P.] 11th hour Cerebral edema, ischemia, hypoxia and hemorrhage [Z.P.] 12th hour Brain tumours. Seizures in the dog. Canine idiopathic epilepsy. Principles of antiepileptic therapy [Z.P.] 13th hour Cerebellar and vestibular syndrome. Ischemic myelopathy and diskospondylitis in the dog. Degenerative myelopathy. Spinal cord tumours. Polyneuropathies, canine idiopathic polyradiculoneuritis [Z.P., N.S.]

59BNeurosurgery of the Dog and Cat 14th hour Central and peripheral nervous system trauma. Acute brain trauma (pathophysiology, clinical signs, complications, treatment). Spinal cord trauma (pathophysiology, clinical signs, treatment). Peripheral nerve injuries [G.K.] 15th hour Surgery of the CNS I. Intervertebral disk disease (pathophysiology, clinical syndroms, treatment). Caudal cervical spondylomyelopathy (pathophysiology, diagnosis, treatment). Lumbosacral disordes. Vertebral fractures/ luxations [G.K.] 16th hour Surgery of the CNS II. Congenital anomalies (atlantoaxial luxation/subluxation, arachnoid cysts). Spondylitis and discospondylitis. Vertebral neoplasia [G.K.] 17th hour Surgery of the CNS III. Hydrocephalus. Brain tumours. Brain abcess [G.K.] 18th hour Surgery of the PNS. Focal peripheral neuropathies. Brachial plexus injuries and tumours. Facial nerve injuries. Sciatic nerve injuries. Supportive care of the neurosurgical patient [G.K.]

60BInternal Medicine and Surgery of the Equine Nervous System 19th hour Bacterial meningitis, epilepsy, cerebellar abiotrophy and degeneration, viral myeloencephalitis, equine degenerative myeloencephalopathy, equine protozoal myeloencephalitis, cervical vertebral malformation, polyuneuritis equi, rhabdomyolysis [N.D.] 20th hour Clinical examination, peripheral neuropathies (suprascapular, radial, obturator, sciatic, femoral, peroneal), palmar digital neurectomy [N.D.]

61BCattle neurology 21th‐22th hour Meningitis, brain and pituitary abscess, CCN, spongiform encephalopathy, listeriosis, hypocalcaemia, hypo‐ magesaemic tetany [Ni.P.]

62BSmall Ruminant Neurology 23th‐24th hour Scrapie, Visna, CAEV, coenurosis, listeriosis, bacterial meningoenchephalitis, piyuitary abscess, myelitis [Ν.G.]

129 63BSwine neurology 25th hour Aujeszky’s disease. Cytomegalovirus infection. Rabies. Japanese B Encephalitis. Hendra virus infection. Teschen‐ Talfan disease. Streptococcal meningitis. Tetanus [Ε.Τz.]

Musculoskeletal system

64BPathology 1st‐2nd hour Bones. Ectopic calcification and ossification. Abnormalities of growth and development. Disorders of growth and development. Generalised disorders of development: chondrodysplasia, mucopolysaccharidosis, osteopetrosis, osteogenesis imperfecta, congenital hyperostosis of pigs. Localised disorders of development (secondary vertebral myelopathy). Metabolic bone diseases. Degenerative diseases. Inflammation of bone. Bone diseases of unknown aetiology [G.Br.] 3rd‐4th hour Bone neoplasms. Benign neoplasms; malignant neoplasms. Joints. Congenital malformations. Degenerative joint disease. Trauma. Inflammatory diseases. Infectious arthritides. Non‐infectious arthritides [G.Br.] 5th‐6th hour Muscle. Muscular atrophy and hypertrophy. Congenital and inherited myopathies: arthrogryposis; myofibrillar hypoplasia of piglets; congenital muscular hyperplasia in calves and lambs; canine, ovine and bovine muscular dystrophy; steatosis; glycogen brancher enzyme deficiency. Muscle regeneration. Circulatory disturbances. Trauma. Nutritional myopathies of cattle, sheep, goats, pigs and horses. Toxic myopathies. Exertional or stress related myopathies; exertional rhabdomyolysis [G.Br.] 7th‐8th hour Myosititides. Bacterial myositis: suppurative myositis, granulomatous myositis. Actinobacillosis. Haemorrhagic myositis. Myosititides of unknown aetiology: ovine and bovine eosinophilic myositis, canine masticatory myositis. Parasitic myositis: trichinellosis; cysticercosis ; myositis due to Sarcosystis sp., Hepatozoon, Neosporum and Toxoplasma sp. Neoplasms of muscle. Neoplasms of smooth muscle: leiomyoma, leiomyosarcoma. Neoplasms of striated muscle: rabdhomyoma, rabdhomyosarcoma. Tendons. Parasitic diseases of tendons (Onchocerca) [G.Br.]

65BDiagnostic approach 9th hour Muscle biopsy. Electrophysiologic testing [N.S.]

66BMusculoskeletal disorders in dogs and cats 10th hour Myasthenia gravis. Canine masticatory muscle myositis and idiopathic polymyositis [N.S.] 11th‐12th hour Infectious myositis. Feline hypokalemic myopathy and canine exertional myopathy (rhabdomyolysis) [N.S.]

130 13th hour Rheumatoid polyarthritis. Canine idiopathic non‐erosive polyarthritis. Polyarthritis associated with leishmaniosis and ehrlichiosis [N.S.] 14th‐15th hour Retained cartilage cores, congenital osteopathies, panosteitis, hypertrophic osteodystrophy, secondary hypertrophic osteopathy, bone cysts, metabolic osteopathies etc [Ν.Pr.]

67BOrthopaedic Surgery of the Dog and Cat 16th‐21st hour Traumatic conditions of the bones (fractures) ‐ General part: definition, causes, predisposing factors, classification, diagnostic evaluation, treatment, complications. [Ν.Pr.] 22nd‐23rd hour Traumatic conditions of the bones (fractures) ‐ Specific part: fractures of the forelimb and the hindlimb. [Ν.Pr.] 24th hour Non‐traumatic conditions of the bones: diagnostic procedures, tumors. Salvage procedures: arthrodesis, amputation [Ν.Pr.] 25th‐27th hour Non‐traumatic conditions of the joints ‐ General part: Definition, causes, classification, diagnostic evaluation, treatment. Specific part: Luxations of the hindlimb and the forelimb. Non‐traumatic conditions of the joints. Diagnostic procedures, osteoarthritis, infective arthritis, osteochondrosis, tumors [Ν.Pr.] 28th hour Orthopaedic conditions of the skull and mandible. Fractures, craniomandibular osteopathy, (sub)luxation and dysplasia of the temporomandibular joint [S.P.] 29th‐31st hour Congenital and developmental conditions ‐ Forelimb: Congenital luxation of the shoulder and elbow, osteochondrosis of the humeral head, elbow dysplasia, growth deformities of the antebrachium etc. [N.Pr.] Hindlimb: Hip dysplasia, Legg Perths' disease, patellar luxation, osteochondrosis of the femoral condyle and hock etc. [N.Pr.] 32nd hour Traumatic conditions of muscles and tendons. General part: muscle biopsy, principles of treatment. Specific part: dorsal displacement of the scapula, contracture of the infraspinatus muscle, contracture of the quantriceps femoris muscles, Achilles tendon injury etc [N.Pr.]

68BRadiographic interpretation of the disorders of the Eye, Auditory System, Endocrine Glands and Axial and Appendicular Skeleton (Bones and Joints) 33rd hour Radiographic interpretation of disorders of the eye (orbit, retrobulbular masses), of the auditory system (otitis externa and media, nasopharyngeal polyps) and of the endocrine glands (thyroid neoplasia, adrenal hyperplasia , adrenal neoplasia). Investigation of the diseases with the new imaging modalities [P.M.]

131 34th hour Radiographicinterpretation ofdisorders of the skulland brain (fractures, temporomandibularsubluxation and dysplasia, craniomandibular osteopathy, neoplasia,hydrocephalus), of thevertebral column and spinal cord (fractures, Wobbler syndrome, equine syndrome, neoplasia, disc protrusion‐extrusion, discospondylitis, spondylitis, epiphysitis). Investigation of the diseases with the new imaging modalities [P.M.] 35th hour Normal radiographicappearanceof a long bone. Radiographic interpretationoflong bone fractures(radiographic featuresand classification of the fractures, radiographicassessmentof fracture replacement and stabilization, radiographicassessmentof the fracturehealing andhealing complications, osteomyelitis). Most common fractures of the long bones in large animals[P.M.] 36th hour Radiographicinterpretation of bone neoplasms. Radiographic interpretationofosteoarthritis [P.M.] 37thhour Radiographicinterpretation of other bones and joints diseases indogs and cats(osteoporosis, metabolic bone diseases, humeral head osteochondrosis, ununitedossification centre of the glenoid cavity, elbow dysplasia, cranial cruciateligament rupture, patellaluxation, femoral condyleosteochondrosis, osteochondrosis of the talus, panosteitis, premature closureof the physis, hypertrophic osteodystrophy, pulmonaryosteoarthropathy, asepticnecrosis of the femoral head, hip dysplasia). Radiographic interpretation ofother bones and joints diseases inlarge animals (laminitis, navicular diseasesyndrome, pedal osteitis, ossification of the lateral cartilage in thehorse) [P.M.].

69BEquine Musculoskeletal System 38th‐40th hour Clinical examination, bone trauma, inflammation of bones, joint trauma, joint inflammation, muscle trauma, tendonitis, tenosynovitis, inflammation of the bursae, supraspinous bursitis, olecranon bursitis, carpal hygroma, cunean bursitis, epiphysitis, ostochondritis, angular limb deformities, flexural limb deformioties [N.D.] 41st hour Laminitis, navicular disease, fracture of the navicular bone, fracture of the 3rd phalanx, fracture of the proximal sesamoid bones, osteoarthritis of the proximal interphalangeal joint, osteoarthritis of the distal interphalangeal joint [N.D.] 42nd hour Canker and thrush, sole bruising, hoof abscess, penetrating wounds of the hoof, quittor, hoof cracks, avulsion injuries of the hoof, trimming and shoeing and potential complications, keratoma [N.D.]

132 43rd hour Periostitis, exostosis of the small metacarpal/ metatarsal bones, carpal chip fractures, carpal canal syndrome, tarsal osteoarthritis, dislocation of the superficial digital flexor tendon off the calcaneal tuberosity, stringhalt [N.D.] 44th hour Upward fixation of the patella, subluxation of the cervical vertebrae, overgranulation tissue, methods of therapy (hydrotherapy, diathermy, ultrasound, electromagnetic pulse, laser, chiropraxy, swimming, training, x‐rays, acupuncture, counterirritants) [N.D.]

70BMusculosceletal diseases of cattle 45th‐46th hour Clostridial myonecrosis, sarcocystosis (cause, symptoms, diagnosis, treatment, prevention), downer cow syndrome (cause, symptoms, diagnosis, treatment, prevention), muscular dystrophy, osteodystropies (cause, symptoms, diagnosis, treatment, prevention) [H.K.]

71BCattle orthopedics 47th‐48th hour Anconaeal and carpal hygroma, patellar displacement, tendonal spasm of phalangeal muscles, coxal displacement. Lower limb diseases: fracture of 3rd phalanx, endonichitis, infectious foot rot, hoof crackles, hoof overgrowth, interdigital overgrowth, 3rd phalanx ambutation [H.K.]

72BSmall ruminant musculoskeletal diseases 49th‐50th hour Rickets, ostemalacia, fibrous osteodystrophy, congenital osteodystrophy, parodontal disease [Ν.G.]

73BSwine muscoskeletal diseases 51st‐52nd hour Malignant edema. Actinomycosis. Trichinella spiralis infection. Porcine Stress Syndrome. Muscular dystrophy. Piglets hypoglycemia. Infectious diseases of joints. Trauma [Ε.Τz.]

Miscellaneous (18 hours)

74BCattle diseases 2 hours Hypovitaminosis A, B12, K. Copper deficiency, zinc deficiency, cattle toxicology (chlorinated hydrocarbons, organophosphate esters, nitrate salts, lead) [Ni.P.]

75BSmall Ruminant Diseases 4 hours PEM, Pregnancy toxaemia. Hypovitaminosis A, B1, B12, E, K. Hypervitaminosis A, D. Selenium deficiency, cobalt deficiency, zinc deficiency, sheep toxicology‐toxic plants [Ν.G.] 6 hours Abortions. Clinical approach in cases of : a) sudden death and b) chronic weight loss. Application of vaccination programmes. Disease control in biological flocks [Ν.G.]

76BNutritional disorders of swine 2 hours Toxicosis, Nutrient defieciencies and excesses (vitamins, microelements) [Ε.Τz.]

133 2 hours Vaccination and biosecurity programmes against the main infectious and parasitic diseases of swine [Ε.Τz.]

77BRabbit Diseases 2 hours Infectious and parasitic diseases of rabbit [Αl.Κ., Ε.Τz.]

78BExotic and Wild Animal Medicine 1st‐3rd hour Reptiles Families. Squamata (lizards, snakes), Crocodilia (alligators, caiman, crocodiles), Clelonia (turtles, tortoises). Biological Data. 1) Anatomy, physiology, general husbandry, feeding 2) handling 3) clinical examination 4) sampling 5) therapeutics 6) anesthesia 7) euthanasia, 8) hematology, biochemistry and radiology. Lizards. Iguana iguana. Hypervitaminosis D3. Nutritional Osteodystrophy. Pneumonia. Necrotic stomatitis. Anorexia, regurgitation, constipation syndrome. Enteritis. Parasitic diseases (gastrointestinal and respiratory tract). Dystocia. Cloacal/penis prolapse. Tail necrosis. Fractures and Injuries management. Skin Disorders. Snakes. Boa constrictor, Python regious, Python molurus. Hypovitaminosis A, B1, C. Pneumonia. Necrotic Stomatitis. Anorexia, regurgitation, constipation syndrome. Dystocia. Cloacal/penis prolapse. Foreign bodies in the gastrointestinal tract. Skin burns. Conjunctivitis, sub‐ spectacular abscesses. Parasitic diseases (gastrointestinal and respiratory tract). Turtles and turtoises. Testudo hermania, Testudo Graeca, Trachemys scripta, Pseudomys scripta, Chrysemys sp. Hypovitaminosis A. Nutritional osteodystrophy. Soft shell syndrome. Upper respiratory tract infections Pneumonia, Stomatitis. Enteritis. Parasitosis (gastrointestinal and respiratory tract). ‘Post‐ hibernation syndrome.” Dystocia. Beak deformities. Aural abscesses. Blepharitis/conjunctivitis. Shell fractures [M.K., Αn.Κ.]

4th‐5th hour Mammals Hamster. Cricetidae (Mesocricetous auratous, Cricetulus griseous, Cricetus cricetus, Phodopus sugorus). Biological Data. 1) Anatomy, physiology, general husbandry, feeding 2) handling 3)clinical examination 4) sampling 5) theurapeutics 6) anesthesia 7) hematology, biochemistry and radiology. “Wet tail syndrome” proliferative ileitis Tyzzer’s disease. Enteritis. Constipationand rectal prolapse. Dental diseases. Cheek pouches impaction/infection. Pneumonia. Cardiac thrombosis. Lymphocytic choriomeningitis. Cage paralysis

134 syndrome.Urogenital disorders. Blepharitis/conjunctivis/ keratitis. Skin disorders. Cannibalism [M.K., Αn.K.] 6th hour Guinea pig. (Cavia porcellus). Biological Data. 1) Anatomy, physiology, general husbandry, feeding 2) handling 3)clinical examination 4) sampling 5) therapeutics 6) anesthesia 7) hematology, biochemistry and radiology. Hypovitaminosis C. Lymphocytic choriomeningitis. Bacterial pneumonia. Dental diseases. Enteritis. Constipation. Pregnancy toxaemia. Vaginitis/Pyometra. Urolithiasis‐cystitis Mastitis and mammary tumors. Conjunctivitis. Otitis media. Cervical lymphadenitis. Skin disorders [Μ.Κ., Αn.Κ.] 7th hour Chipmunks. (Eutamias sibiricus). Biological Data. 1) Anatomy, physiology, general husbandry, feeding 2) handling 3)clinical examination 4) sampling 5) theurapeutics 6) anesthesia 7) hematology, biochemistry and radiology. Bacterial pneumonia. Enteritis. Dental diseases. Hypocalcemia. Seizures.. Mitritis/pyomytra. Urethritis/ cystitis. Skin disorders [Μ.Κ, Αn.Κ.] 8th hour Primates. Biological Data. 1) Anatomy, physiology, general husbandry, feeding 2) handling 3) clinical examination 4) sampling 5) therapeutics 6) anesthesia 7) hematology, biochemistry and radiology. Prosimii (prosimians) Antropoidea (simians), Cebidae (capuchins), Callithricidae (marmosets, tamarins), Cercopithecidae (patas, babbon, maquaque) Hyalobatinae (gibbons), Pongidae (gorilla, chimpanzee, orangutan). Diseases. Nutritional bone desease. Herpes virus infection. Viral Hepatitis. Measles. Rubella. Tuberculosis. Enteritis. Acute gastric dilatation. Pneumonia. Parasitic diseases. Wasting Marmoset syndrome. Skin disorders. Basic principles of Rescue and Rehabilitation of wild animals of the Greek Fauna (brown bear, wolf, fox, seals, sea turtles, cetaceans). Legislation, Public Health [Μ.Κ, Αn.Κ.] Anaesthesiology–Intensive Care 1st hour Local anaesthesia (anaesthetic potency, anaesthesia onset and duration, mode of action of local anaesthetics, toxicity, local anaesthetic drugs, local anaesthesia techniques) [D.R., I.S.] 2nd hour Local anaesthesia at various animals (equine, ruminants, swine, carnivores) [D.R., I.S.] rd 3 hour Sedatives‐tranquilizers (phenothiazines, a2‐adrenergic agonists, butyrophenones, benzodiazepines) and anticholinergics [D.R., I.S.] 4th hour Analgesia (pain pathophysiology, pain recognition and assessment, analgesic drugs, clinical cases) [D.R., T.A.]

135 5th hour General anaesthesia (introduction, animal preparation, levels of anaesthesia, routes of administration anaesthetic drugs) [D.R., I.S.] 6th hour Injectable anaesthetics (thiopentone, propofol, ketamine, chloral hydrate, etomidate) [D.R., I.S.] 7th hour Inhalants (halothane, isoflurane, sevoflurane) [D.R., I.S.] 8th hour Anaesthetic accidents and complications (shock, hypoxia, hypercapnia, apnoea etc.) [D.R., I.S.] 9th hour General anaesthesia in horses, ruminants and, swine [D.R., I.S.] 10th hour General anaesthesia in carnivores, wild and exotic animals [D.R., I.S.] 11th hour Special anaesthetic considerations I (paediatric anaesthesia, geriatrics, respiratory diseases, circulatory diseases, myocardial diseases) [D.R., T.A.] 12th hour Special anaesthetic considerations II (animals with renal disease, feline lower urinary tract obstruction, lower urinary tract rupture, liver disease, endocrine disease, CNS diseases, gastrointestinal diseases, gastric dilatation‐ volvulus) [D.R., T.A.] 13th hour Special anaesthetic considerations III (hematological diseases, pyometra, ocular disorders, caesarian section, high risk patients, trauma, obese animals, brachycephalic breeds, sighthounds, Chow‐Chows and Sharpeis) [D.R., T.A.] 14th hour Neuromuscular block (applied physiology of the respiratory system, drugs and their clinical use, artificial ventilation) [D.R., I.S.] 15th hour Patient monitoring (clinical and electronic) [D.R., I.S.] 16th hour Fluid and electrolyte disorders I (distribution of body fluids, disorders of water distribution, disorders of electrolyte balance, acid‐base balance, types of fluids, clinical cases) [D.R., I.S., G.K.] 17th hour Fluid and electrolyte disorders II (shock, clinical cases, transfusion) [D.R., I.S., G.K.] 18th hour Disseminated Intravascular Coagulation (DIC) (causes, therapy) [D.R., I.S., G.K.] 19th hour Cardiopulmonary resuscitation (causes, therapy) ([D.R., I.S., G.K.] 20th hour General principles of critical care (small animals with life‐ threatening illness, examples of clinical cases) [D.R., I.S., G.K.]

Anaesthesiology – Intensive Care (Practicals) (G.K., D.R., I.S., T.A.) 1 hour Equipment (syringes, needles, intravenous catheters, fluid administration sets, 3‐way stop‐cocks)

136 1 hour Local anaesthesia I (brachial plexus block in the dog, epidural anaesthesia in the dog) 1 hour Local anaesthesia II (palmar and pedal blocks in horses, paravertebral block in cows) 1 hour Anaesthetic machines (gas cylinders, pressure reducing valves, flowmeters, vaporizers, anaesthetic breathing systems, scavenging systems) 1 hour Anaesthetic equipment (endotracheal tubes, laryngoscopes, ambu bags, face masks) 1 hour Tracheal intubation 1 hour General anaesthesia (induction, maintenance, monitoring of the cardiovascular, respiratory, and central nervous systems, anaesthetic depth) 1 hour Monitoring (electrocardiography, oximetry, arterial blood pressure, capnometry‐capnography, spirometry, respiratory gases analysis) 1 hour Cardiopulmonary resuscitation 1 hour Drug dose calculation (solution preparation, solution dilution, calculation of volume required, calculation of drips)

Avian Medicine

79BNutritional diseases 1st‐2nd hour Vitamins A, D, E/Se and K deficiency. Related syndromes/diseases (aetiology, clinical signs and macroscopic lesions, differential diagnosis, treatment) [I.G.] 3rd hour Other vitamins and essential inorganic elements defiency [I.G.] 4th hour Related syndromes/diseases [I.G.]

80BBacterial Diseases 5th‐7th hour Salmonella infections [I.G.] 8th‐9th hour Colibacillosis, Pasteurellosis, Pseudotubercullosis [I.G.] 10th hour Tuberculosis, Staphylococcosis, Streptococcosis. Pseudomonas infection [I.G.] 11th hour Clostridial diseases, Erysipelas infection, Listeriosis, Spirochetosis, Avian vibrionic hepatitis, Infectious coryza [I.G.] 12th hour Mycoplasmosis [I.G.] 13th hour Avian Chlamydiosis (psittacosis, ornithosis), Aegyptianellosis [I.G.]

81BFungal diseases 14th hour Aspergillosis, Candidiasis, Dermatophytosis, Histoplasmosis, Cryptococcosis, Mycotoxicoses, Ascites [I.G.]

82BViral diseases 15th hour Newcastle disease [I.G.]

137 16th hour Infectious laryngotracheitis [I.G.] 17th hour Infectious bronchitis, Bluecomb disease [I.G.] 18th hour Fowl pox [I.G.] 19th hour Avian encephalomyelitis, Infectious bursal disease, Chicken infectious anaemia [I.G.] 20th hour Avian pneumoviruses, Duck hepatitis, Turkey viral hepatitis, Turkey bluecomb disease, Arbovirus infections [I.G.] 21th hour Avian influenza, Duck plaque, Reovirus infections [I.G.] 22th hour Adenovirus infections [I.G.] 23th hour Neoplastic diseases [I.G.]

83BParasitic diseases 24th hour Coccidiosis [I.G.] 25th hour Trichomoniases, Histomoniasis, Hexamitiasis [I.G.] 26th hour Sarcosporidiasis, Toxoplasmosis, Leucocytozoonosis and other avian haemoparasites. Respiratory system parasites. Parasites of pharynx, esophagus and crop [I.G.] 27th hour Parasites of the digestive tract [I.G.] 28th hour External parasites of birds. Insects, mites, ticks [I.G.]

Practical training in the Clinics and Necropsy Room (rotation) 4 In the Clinic of Companion Animals and in the Large Animal Clinic: 39 hours/student 5 In the Clinic of Avian Medicine: 26 hours/student 6 In Anesthesiology ‐ Intensive Care Unit: 10 hours/student 7 In the Necropsy Room: 12 hours/student

138

MODULE 9th & 10th Semester (clinical practice of student groups) Hours/semester

94BL P ECTS Clinical Sciences V (weeks per discipline) Necropsy Room 1, Avian Medicine 1, Small Ruminants 2, Large Ruminants 5, Diseases of Pigs 2, 8th (V) Companion Animal Medicine 5, Surgery and Reproductive 660 47.5 Disorders of Companion Animals 5, Equine Medicine and Surgery 0.5, Diagnostic Imaging 1.5, Anaesthesiology‐ Intensive Care 2, Exotic Animals 0.5

29BTotal 660 47.5

8th (V) Course ‐ 9th & 10th Semester

120BFinal Year Practical Training Rotations ‐ Clinical Sciences V

This module includes an array of disciplines that largely covers the clinical training of the veterinary students. It includes necropsy training (1 week), avian medicine (1 week), small ruminant medicine (2 weeks), large ruminant medicine (5 weeks), diseases of pigs (2 weeks), companion animal medicine (5 weeks), surgery and obstetrics of companion animals (5 weeks) and equine medicine and surgery (0.5 week), diagnostic imaging (1.5 weeks), anesthesiology – critical care (2 weeks) and exotics (0.5 week). It also includes 4 weeks of elective clinical or meat inspection topics.

95BLearning objectives To effectively establish and practice all the first day skills required by a graduate of veterinary medicine. Briefly, the overall objectives are: 1) To respect personal, social and professional ethics. 2) To demonstrate communication skills with colleagues and owners. 3) To keep abreast of the recent scientific advances. 4) To become familiar with basic principles of practice management and become active – experienced in: obtaining animal and herd history, animal handling and restraining, clinical examination, sample collection and shipment, diagnostic approach, proper tests application and results interpretation, preventive medicine and therapeutic advising, medical and surgical treatment, including aseptic process, anesthesia, first aids, emergency assistance and euthanasia considerations, animal nursing and follow up. 5) To introduce students to biopsy and necropsy procedures; to perform necropsy in all animal species in order to understand and learn the occurrence, development and progression of pathological lesions in body systems and to individual organs, and to relate their morphology at gross and microscopic level to clinical recognizable functional defects and disease states; to study and interpret

139 necropsy and macroscopic lesions in such a way as to make a meaningful diagnostic assessment in relation to “in vivo” clinical observations. 6) To demonstrate an interdisciplinary cooperation drive. 7) To raise public awareness on public health issues. Necropsy Students will acquire: 1. Knowledge of the pathogenesis and pathology of clinically important /common animal diseases to provide a foundation for their clinical studies. 2. Further enhancement of their observational, descriptive and interpretive skills in problem‐solving exercises using clinico‐pathological material and laboratory data. 3. Further reinforcement of the principles of disease diagnosis and an appreciation of the value of further investigation/research.

Sections of oral examinations of 9th and 10th Semester Module 8th (V) (The exams are carried out in the end of 10th semester)

Section 1st: Companion and exotic animal medicine Section 2nd: Small animal surgery ‐ Ophtalmology ‐ Equine medicine and surgery Section 3rd: Anaesthesia and intensive care ‐ Imaging diagnosis ‐ Obstetrics and Reproductive Disorders of Companion Animals Section 4th: Surgery and Medicine of production animals Section 5th: Obstetrics and Reproductive Disorders of production animals Section 6th: Pathology‐Avian medicine

Elective topics of 9th semester 1. Management interventions for the improvement of reproductive parameters and the udder health of productive animals (10 hours lectures, 24 hours practicals) 2. Husbantry and medicine of production animals ‐ Cattle (10 hours lectures, 40 hours practicals) 3. Companion animal medicine Ι (12 hours lectures, 40 hours practicals) 4. Food safety and food inspection in practice (regulations and the role of the veterinarian). Fish processing technology. Packaging of food of animal origin (10 hours lectures, 21 hours practicals) 5. Hygiene of Foods of Animal Origin‐ Development and implementation of HACCP systems in the Food Industries. Infrastructure and operation of food of animal origin processing establishments (20 hours lectures, 52 hours practicals) 6. Small animal anaesthesia and intensive care (12 hours lectures, 25 hours practicals) 7. Obstetrics of companion animals (4 hours lectures, 25 hours practicals) 8. Companion animal dentistry (5 hours lectures, 25 hours practicals)

140 9. Small animal soft tissue surgery I (30 hours practicals) 10. Canine & feline orthopaedics and neurosurgery (12 hours lectures, 50 hours practicals) 11. Οphthalmology (10 hours lectures, 25 hours practicals) 12. Equine surgery, internal medicine and obstetrics (10 hours lectures, 50 hours racticals)

th 125BElective topics of 10 semester 1. Small animal soft tissue surgery I (30 hours practicals) 2. Equine surgery, internal medicine and obstetrics (10 hours lectures, 50 hours practicals) 3. Canine & feline orthopaedics and neurosurgery (12 hours lectures, 50 hours practicals) 4. Οphthalmology (10 hours lectures, 25 hours practicals) 5. Biotechnology and modern methods of confrontation of reproductive problems and the udder health in farms of productive animals (10 hours lectures, 24 hours practicals) 6. Husbantry and medicine of farm animals‐ Swine (6 hours lectures, 40 hours practicals) 7. Companion Animal Medicine ΙΙ (12 hours lectures, 40 hours practicals) 8. Avian Medicine (12 hours lectures, 30 hours practicals)

Instructors of the 9th and 10th Semester modules 8th (V) module: Clinical Sciences V

Adamama‐Moraitou Katerina K.A.‐M. Anagnostou Tilemahos T.A. Αrsenos Georgios G.Α. Boscos Constantinos C.Bo. Brozos Christos C.Br. Fortomaris Paschalis P.F. Georgopoulou Ioanna I.G. Giadinis Nektarios N.G. Diakakis Nikolaos N.D. Kaldrymidou Eleni Ε.Κ. Karagiannopoulou Maria Ma.K. Karatzias Harilaos H.K. Kazakos Georgios G.K. Kiosis Evangelos E.K.

141 Komnenou Anastasia An.K. Koutinas Alexandros Al.K. Koutinas Christos Ch.K. Κritas Spyridon S.Κ. Kritsepi Maria M.K. Loukopoulos Panayiotis P.L. Mylonakis Mathaios M.M. Panousis Nikolaos Ni.P. Papadimitriou Serafim S.P. Papadopoulou Paraskevi P.P. Papazoglou Lysimahos L.P. Papaioannou Nikolaos Ν.P. Patsikas Michail P.M. Petridou Evanthia E.P. Polizopoulou Zoe Z.P. Poutahidis Theofilos T.P. Prassinos Nikitas N.Pr. Psychas Vassilios V.P. Rallis Timoleon T.R. Raptopoulos Dimitrios D.R Savvas Ioannis I.S. Soubasis Nektarios N.S. Tzika Eleni E.Tz. Tsousis Georgios G.T. Valergakis George G.V. Ververidis Haralambos H.V. Vlemmas Ioannis Ι.V

142

ELECTIVE COURSES

143 ELECTIVE COURSES OFFERED IN THE FACULTY OF VETERINARY MEDICINE

Semester Elective course 4th 5th 6th 7th 8th 9th 10th BREEDS‐NUTRITION–TRAINING–BEHAVIOUR & WELFARE OF 1 DOGS X 2 ECONOMICS OF DISTRIBUTION OF ANIMAL PRODUCTS X TURKEY, QUAIL, GUINEA FOWL, PHEASANT 3 AND PARTRIDGE BREEDING X 4 ORGANIC APICULTURE X 5 ALTERNATIVE METHODS FOR PARASITE CONTROL X ORGANIZATION, MANAGEMENT AND FUNDING OF ANIMAL 6 PRODUCTION ESTABLISHMENTS X MOLECULAR BIOLOGY TECHNIQUES AND THEIR 7 APPLICATIONS IN VETERINARY MEDICINE X

8 ART AND THE BRAIN X

9 BIOETHICS X 10 OSTRICH, DUCK AND GOOSE BREEDING X DIAGNOSIS OF HONEY BEE DISEASES WITH EMPHASIS ON 11 MOLECULAR DETECTION METHODS X 12 ISSUES IN ANALYTICAL AND APPLIED EPIDEMIOLOGY X AQUATIC ENVIRONMENT–INTERACTIONS BETWEEN 13 ENVIRONMENT AND AQUACULTURE X 14 INFECTIOUS DISEASES OF MAJOR IMPORTANCE FOR GREECE X PHYSICOCHEMICAL AND ORGANOLEPTIC METHODS FOR 15 ASSESSING THE QUALITY OF FOOD X BASIC PRINCIPLES OF FOOD CHEMISTRY 16 DISEASES OF FARMED AQUATIC ANIMALS X 17 ENTREPRENEURSHIP AND INNOVATION X 18 COMPARATIVE PATHOLOGY OF NEOPLASIA X 19 DIAGNOSTIC IMAGING X HUSBANDRY AND DISEASES OF FARM ANIMALS: 20 SMALL RUMINANTS X 21 FOOD BIOTECHNOLOGY X 22 FOOD MICROBIOLOGY X 23 HYGIENE AND TECHNOLOGY OF DAIRY PRODUCTS X Semester

144 Elective course 4th 5th 6th 7th 8th 9th 10th 24 FOOD TOXICOLOGY X MANAGEMENT INTERVENTIONS FOR THE IMPROVEMENT OF 25 REPRODUCTIVE PARAMETERS AND THE UDDER HEALTH IN FARMS OF PRODUCTION ANIMALS X HUSBANTRY AND MEDICINE OF PRODUCTION 26 ANIMALS: CATTLE X 27 SMALL ANIMAL MEDICINE I X FOOD SAFETY AND FOOD INSPECTION IN PRACTICE

27 (REGULATIONS AND THE ROLE OF THE VETERINARIAN). FISH PROCESSING TECHNOLOGY. PACKAGING FOR FOOD OF X ANIMAL ORIGIN HYGIENE OF FOODS OF ANIMAL ORIGIN HACCP SYSTEM DEVELOPMENT AND IMPLEMENTATION IN 28 FOOD ESTABLISHMENTS STRUCTURE AND OPERATION OF PROCESSING UNITS OF X PRODUCTS OF ANIMAL ORIGIN 29 SMALL ANIMAL ANAESTHESIA AND INTENSIVE CARE I&II X X 30 SMALL ANIMAL OBSTETRICS I&II X X 31 SMALLANIMAL DENTISTRY I&II X X 32 SMALL ANIMAL SOFT TISSUE SURGERY I&II X X 33 CANINE & FELINE ORTHOPAEDICS AND NEUROSURGERY I& II X X 34 ΟPHTHALMOLOGY I&II X X 35 EQUINE SURGERY, MEDICINE AND OBSTETRICS I&II X X BIOTECHNOLOGY AND MODERN METHODS OF 36 CONFRONTATION OF REPRODUCTIVE PROBLEMS AND THE UDDER HEALTH IN FARMS OF PRODUCTION ANIMALS X HUSBANTRY AND MEDICINE OF PRODUCTION ANIMALS: 37 SWINE X 38 SMALL ANIMAL MEDICINE II X 39 AVIAN MEDICINE X

An elective course which is offered in two semesters can only be taken one time in either of the two semesters. X: semester in which the elective course is offered

145 BREEDS – NUTRITION – TRAINING ‐ BEHAVIOUR & WELFARE OF DOGS

LECTURES

1st‐4th hour Dog breeds [Α.Τ.‐G] 5th‐6th hour Dog nutrition [P.P., E.C.] 7th‐8th hour Dog training [A.T.‐G.] 9th‐12th hour Behaviour and welfare of dogs [A.T.‐G.]

PRACTICALS 6 hours

The course is taught at the 4th semester. The previous attendance of the course “Pet rearing” (4th Module, III) is mandatory.

Minimum required number of enrolled students: 5 Maximum allowable number of enrolled students: 30

Instructors: Tserveni‐Gousi A. [A.T.‐G], Paneri P. [P.P.], Christaki E. [E.C.]

ECTS: 2.0

146 30BECONOMICS OF DISTRIBUTION OF ANIMAL PRODUCTS

LECTURES 1st‐4th hour Theory of consumer’s behavior of animal products, consumer’s budget line, indifference curves, consumer’s equilibrium, demand analysis of animal products, price of the demanded product, price elasticity of demand. Disposable income ‐ consumer’s preferences, market demand curve

5th‐8th hour Supply analysis of animal products, the price of the product supplied, price elasticity of supply. Objectives of the producer, industry supply curve. Equilibrium in the market of animal products, price determination

9th‐12th hour Functions of trading products of animal origin (packaging, transportation), identification of products, systems of trading. Information – market research and supply policy of products of animal origin

PRACTICALS

1st‐4th hour Design of specialized questionnaires, market research for various products of animal origin, acquisition and analysis of data, design of the profile of the Greek consumer of products of animal origin

The course is offered during the 4th semester of studies. It is required that students will have succeeded in the course “Animal Production Economics” which is taught in the 4th II Module.

Minimum number of students: 15 Maximum number of students: 30

Instructor: Ch. Batzios [C.B.]

ECTS: 2.0

147 TURKEY, QUAIL, GUINEA FOWL, PHEASANT AND PARTRIDGE BREEDING

LECTURES 1st‐2nd hour Turkey rearing 3rd‐4th hour Quail rearing 5th‐6th hour Guinea fowl rearing 7th‐8th hour Pheasant rearing 9th‐10th hour Partridge rearing

PRACTICALS 8 hours

Completion of this course requires a written examination. The course belongs to the 4th semester of studies. The previous attendance of “Poultry farming” (Module 4 III) is a requirement for enrollment.

Minimum number of students: 5 Maximum number of students: 30

Instructors: A. Tserveni‐Gousi [A.T.‐G], P. Fortomaris [P.F.]

ECTS: 2.0

148 ORGANIC APICULTURE LECTURES 1st ‐2nd hour General principals of organic apiculture. Legal frame and considerations for production of organic hive products. Organic hive maintenance. 3rd – 4th hour Bee keeping management. Special management activities, bee feeding and transferring. 5th – 6th hour Basic rules for organic production of honey and other products of the hive. Beekeeping systems and selection for bee plants. 7th – 8th hour Prevention and control of the principal diseases of the honey 9th – 10th hour bee using organic non chemical methods and biotechnology.

PRACTICALS 1st ‐4th hour Hive inspection. Special management activities, swarming and development. 5th – 8th hour Feeding, uniting and transferring hives. 9th – 12th hour Practical application of methods to control honey bee diseases with organic and biotechnical methods.

Completion of this course requires a written examination. The course belongs to the 4th semester of studies.

Minimum required number of enrolled students: 15 Maximum allowable number of enrolled students: –

Instructor: E.Papadopoulos [E.P.]

ECTS: 2.0

149 ALTERNATIVE METHODS FOR PARASITE CONTROL

LECTURES 1st–2nd hour Introduction to resistance of parasites to chemical control. Development of parasite resistance. Methods to detect resistance (in vivo, in vitro, molecular etc). General principals to prevent the development of resistant strains of parasites to antiparasitic drugs

3rd–4th hour Resistant strains of helminths (mostly nematodes of farm animals). Methods of anthelmintic use and alternative to chemical methods (biological) to control nematodes

5th–6th hour Resistant strains of arthropod parasites (mostly ticks and insects infesting animals). Methods of acaricide/insecticide use and alternative to chemical methods (biological) to control arthropod parasites

7th–8th hour Resistant strains of protozoan parasites (mostly coccidian) Methods of antiprotozoal/anticoccidial use and alternative to chemical methods (biological) to control protozoan parasites

PRACTICALS

This course is placed in the 5th semester of studies. Prerequisite is the successful holding of the subject Parasitic Diseases taught at the 6th Module I.

Minimum required number of enrolled students: 10 Maximum allowable number of enrolled students: 40

Instructor: E. Papadopoulos [E.P.]

ECTS: 1.0

150 ORGANIZATION, MANAGEMENT AND FUNDING OF ANIMAL PRODUCTION ESTABLISHMENTS

LECTURES 1st‐4th hour Organization of production factors in animal production establishments (capital, land, labor). Factors influencing profit in animal production establishments (temporary and permanent establishments). Break‐even product. Funding of animal production establishments (importance, sources, instruments and policy). Agricultural credit (necessity, principles, regulations of agricultural credit)

5th‐8th hour Strategic management and organization of animal production establishments, analysis of internal and external environment. Legal framework of investments plans in animal production establishments. Principles of constructing a business plan in animal production establishments

9th‐12th hour Legal structure forms of animal production establishments. Criteria for selection the legal structure of animal production establishments. Elements of commercial and labor law (trader, trader acts, taxation, Greek Accounting Standards, labour agreement, employer/worker engagements, salary, work permit, completion of employment)

PRACTICALS

1st‐4th hour Amortization, examples of time value of money, evaluation of investment projects in animal production

The course is offered during the 5th semester of studies. It is required that students will have succeeded in the course “Animal Production Economics” which is taught in the 4th II Module.

Minimum number of students: 15 Maximum number of students: 30

Instructor: Ch. Batzios [C.B.]

ECTS: 2.0

151 MOLECULAR BIOLOGY TECHNIQUES AND THEIR APPLICATIONS IN VETERINARY MEDICINE

LECTURES 1st hour DNA/RNA isolation. Restriction endonucleases 2nd hour Nucleic acid hybridization. Southern and Northern blotting. 3rd hour RFLP 4th‐7th hour Polymerase chain reaction (PCR) and its variations. RT‐PCR. Nested PCR. Multiplex PCR. In‐situ PCR. PCR‐ELISA. Real‐ time PCR 8th‐9th hour DNA sequencing and identification of mutations‐ polymorphisms 10th hour DNA microarrays

PRACTICALS 2 hours DNA extraction. PCR. Electrophoresis

Completion of this course requires a written examination. The course belongs to the 5th semester of studies. The previous attendance of the 1st Module (1st section) of studies is a requirement for enrollment.

Minimum required number of enrolled students: 5 Maximum allowable number of enrolled students: –

Instructor: K. Angelopoulou [K.A.]

ECTS: 2.0

152 ART AND THE BRAIN LECTURES 1st hour Art is the product of the function of the brain, the function of art and the function of the visual brain are one and the same 2nd hour Art and evolution 3rd hour Two basic functional laws of the visual brain: abstraction and constancy: Abstraction and painting Constancy in art 4th hour Neurobiology and cubism 5th hour Anatomical organization of the visual system Light and retina Parallel processing 6th hour The receptive field‐ The “art of the receptive field” Modrian, Malevich and Kandinsky 7th hour Kinetic art and area V5 8th hour Prosopagnosia and portraits 9th hour The neurobiology of abstract and representational art 10th hour Brain pathology affects artistic style 1 The blind painter

PRACTICALS

Completion of this course requires a written examination. The course belongs to the 3rd semester of studies. The previous attendance of the 2nd Module (1st, 2nd Sections) of studies is a requirement for enrollment.

Minimum required number of enrolled students = 5 Maximum allowable number of enrolled students = –

Instructor: Athanasios Dinopoulos [A.D.]

ECTS: 1.0

153 BIOETHICS

LECTURES 1st‐20th hour Description of the course Elective course “Bioethics” examines ethical problems‐dilemmas caused by the biological research, its applications and the contemporary scientific practice. It comprises free presentations by Professor G. C. Papadopoulos, invited speakers and students.

PRACTICALS Semester The course is taught during the 5th semester (2 hrs/week)

Student number Minimum: 10 Maximum: –

Exams Students are expected to work out an essay on a subject of their choice.

Instructor: G.C. Papadopoulos [G.C.P.]

ECTS: 1.5

154 OSTRICH, DUCK AND GOOSE BREEDING

LECTURES

1st‐4th hour Ostrich rearing 5th‐7th hour Duck rearing 8th‐10th hour Goose rearing

PRACTICALS 9 hours

The course is taught at the 4th semester. The previous attendance of the course “Poultry Farming” (4th Module III) is mandatory.

Minimum required number of enrolled students: 5 Maximum allowable number of enrolled students: 30

Instructors: Tserveni‐Gousi A. [A.T.‐G], Fortomaris P. [P.F.]

ECTS: 2.0

155 DIAGNOSIS OF HONEY BEE DISEASES WITH EMPHASIS ON MOLECULAR DETECTION METHODS

LECTURES 1st ‐2nd hour General introduction principals to the honeybee physiology. Review of the microorganisms affecting the bee and their pathogenic effect. Clinical picture and control methods. 3rd – 4th hour Approaching honey bee diseases according to colony maintenance. Methods to collect pathologic material. 5th – 6th hour Molecular diagnostic examinations to detect and identify viruses infecting bees. 7th – 8th hour Molecular diagnostic examinations to detect and identify bacteria infecting bees. 9th – 10th hour Molecular diagnostic examinations to detect and identify parasites infecting bees.

PRACTICALS 1st ‐2nd hour Handling of the pathologic material in order to detect RNA viruses, bacteria and parasites infecting bees. 3rd – 4th hour Application of molecular methods to detect and identify RNA viruses. 5th – 6th hour Application of molecular methods to detect and identify bacteria. 7th – 8th hour Application of molecular methods to detect and identify parasites (protozoan and metazoan).

Completion of this course requires a written examination. The course belongs to the 5th semester of studies.

Minimum required number of enrolled students: 5 Maximum allowable number of enrolled students: 20

Instructors: Dovas C. [C.D.],, E. Papadopoulos [E.P.]

ECTS: 2.0

156 ISSUES IN ANALYTICAL AND APPLIED EPIDEMIOLOGY

LECTURES 1st–2nd hour The use of statistical analytical methods in Epidemiology. The role of natural variability of characteristics of animal populations in the estimation of epidemiologic population parameters and causal relationships 3rd–5th hour Evaluation of results of epidemiologic studies: estimation and hypothesis testing about epidemiologic population parameters. Evaluation of results of epidemiologic studies: statistical and biological significance 6th–7th hour Measures of association between possible causes and outcomes of interest in epidemiologic studies 8th‐9th hour Confounding and interaction in epidemiologic studies 10th hour Prevention and control of confounding and description of interaction in epidemiologic studies

PRACTICALS 1 hour Calculation of sample size for epidemiologic studies 2 hours Analysis of results of simple experimental epidemiologic studies. The effect of sample size on statistical significance and estimation of relationships between exposures and outcomes in epidemiologic studies 3 hours Design of epidemiologic studies 2 hours Discussion of published epidemiologic studies 2 hours Stratified analysis of data from epidemiologic studies. Analytical approach to control of confounding and description of statistical interaction. Interpretation and reporting of results of epidemiologic studies

This course is offered during the 6th semester of studies. Prerequisites are the previous attendance of Biostatistics, which is taught in the 3rd I Module and the successful examination of the course “Epidemiology”, which is taught in the 3rd II Module

Minimum required number of enrolled students: 10 Maximum allowable number of enrolled students: 30

Instructor: Marios Georgiadis [M.G.]

ECTS: 2.0

157 AQUATIC ENVIRONMENT–INTERACTIONS BETWEEN ENVIRONMENT AND AQUACULTURE

LECTURES 1st hour Introduction ‐ Environmental impacts on aquaculture 2nd hour The drainage basin of aquatic ecosystems 3rd hour Sources of pollution and nutrients 4th hour The aquatic ecosystem ‐ characteristics. 5th hour Water quality 6th hour Water trophic conditions 7th hour Water pollution 8th hour Influence of aquaculture on the environment 9th hour Impacts of aquaculture on the environment ‐ physical impacts 10th hour Biological impacts 11th hour Pollution control and management of the aquaculture effluents. Site selection for the installation of aquacultures 12th hour Environmental interactions assessment. Environmental impact assessment studies

PRACTICALS 6 hours Influence of inland water aquaculture on the environment (fish farms) 6 hours Influence of marine aquaculture on the environment (fish farms)

This course is offered during the 6th semester of studies. Prerequisite is the previous attendance of “Farming and Pathology of Aquatic Organisms”, which is taught in the 7th (III) Module.

Minimum number of students: 5 Maximum number of students: 30

Instructors: Ath. Kamarianos [A.K.], Xan. Karamanlis [X.K.]

ECTS: 2.5

158 INFECTIOUS DISEASES OF MAJOR IMPORTANCE FOR GREECE

LECTURES 1th‐3rd hour Brucellosis [Ε. B‐H., H.K.] 4th‐6th hour Clostridiosis [E.B‐H, N.G.] 7th‐10th hour Bovine, ovine, caprine and swine mycoplasmosis [Ε.P., Ε.Τz., Ν.G.] 11th‐12th hour Tuberculosis, paratuberculosis [V.S., Ν.G.] 13th –14th hour Enzootic abortion [V.S., Ν.G.] 15th‐17th hour Swine viral diseases (Porcine Reproductive and Respiratory Syndrome, Aujeszky’s disease (pseudorabies), parvoviral infection, postweaning multisystemic wasting syndrome [S.K., E.Tz.] 18th‐20th hour Respiratory infections of bovine (Bovine viral diarrhoea‐ mucosal disease, infectious rhinotracheitis, parainfluenza, respiratory syncytial virus, Manhaemia infection) [S.K., E.Tz.] 21st‐24th hour OIE listed diseases and other diseases of importance to international trade (Bluetongue, Sheep pox and goat pox, Maedi‐Visna, Caprine arthritis/encephalitis, Ovine pulmonary adenomatosis, Transmissible spongiform encephalopathies [Bovine spongiform encephalopathy (BSE), Scrapie] [M.P., N.G.] 25th‐28th hour OIE listed diseases (Foot‐and‐mouth disease, classical swine fever, Anthrax). Population dynamics of infection. Monitoring surveillance systems [S.K., M.G., N.G., E.P.]

Each course has 2 hours of lectures (theoretical part) and 2 hours of discussion and queries (tutorial part)

This course is placed in the 7th semester of studies. Prerequisite is the successful holding of the subject “Infectious diseases” taught at the 6th II Module.

Minimum number of students: 10 Maximum number of students: –

Instructors: Georgiadis M. [M.G.], Giadinis Ν. [Ν.G], Dovas C. [C.D.], Karatzias H. [H.K.], Kritas S. [S.K.], Bourtzi‐Hatzopoulou Ε. [Ε.B‐H.], Panousis Ν. [N.P], Petridou Ε. [E.P.], Siarkou V., [V.S.], Tzika Ε., [E.Tz.]

ECTS: 2.5

159

PHYSICOCHEMICAL AND ORGANOLEPTIC METHODS FOR ASSESSING THE QUALITY OF FOOD BASIC PRINCIPLES OF FOOD CHEMISTRY

LECTURES 1st hour Organoleptic quality assessment or sensory assessment as a means of determining quality. Methods and materials. Analytical tools, tests, scoring schemes [Ι.Α.] 2nd hour Physical methods of food quality assessment. Parameters and critical control points in HACCP systems. pH, aw, temperature, relative humidity, colour, redox potential determination methods [Ι.Α.] 3rd hour Introduction to Food Chemistry. Water and ice. Carbohydrates. Physicochemical properties [Α.P.] 4th‐5th hour Fats. Physicochemical properties. Amino acids, peptides, proteins. Physicochemical properties. Vitamins, enzymes, inorganic food constituents, colours, flavourings [Α.P.] 6th hour Chemical composistion and nutritive value of meat (mammals, birds, fish), eggs and meat based products. New trends in food products, low caloric value foods, functional foods [Α.P.]

PRACTICALS 1st‐2nd hour Introduction to the methodology of sensory assessment of food. Smell, taste, aroma: meanings, examples. Perception of various textural characteristics, e.g. tenderness, juiciness, and colour. Determination and discrimination among the four basic tastes in aqueous solutions and meat‐based products (beef paties). Classification tests. Strength of a basic taste in aqueous solutions. Colour in aqueous solutions 3rd‐4th hour The presence of spices in aqueous solutions and meat‐ based products (determination, discrimination). Classification tests according to taste characteristics in products of animal origin fat content of cheeses, tenderness of cheeses, juiciness of meat). Triangle tests in cheeses and sausages 5th‐6th hour Scoring schemes for assessing the quality of various products. Grading scores schemes and forms for description and evaluation. Assessment and evaluation of ready made foods with components of animal origin. Sensory evaluation of various foods of animal origin, e.g. delicatessen, surimi, salted fish, cheeses, etc. 7th‐9th hour Sampling and preparation of samples for chemical analysis (meat products). Determination of nitrite concentration in meat products. Measurements of various physicochemical

160 parameters in foods (pH, aw, temperature etc.). Evaluation of the results 10th‐12th hour Determination of total volatile basic nitrogen as a quality index of fish and fish‐based products (TVB‐N). Determination of the degree of lipid oxidation in foods of animal origin. Theiobarbituric acid test 13th‐15th hour Determination of NaCl concentration in meat products (mammals, birds). Determination of the degree of lipid oxidation in foods of animal origin through the peroxide value

Completion of this course requires a written examination. The course belongs to the 7th semester of studies. The previous attendance of the 7th (II) Module of studies is a requirement for enrollment.

Minimum required number of enrolled students: 5 Maximum allowable number of enrolled students: 25

Instructors: Ambrosiadis, I. [I.A.], Papavergou A. [A.P.], Zetou F. [F.Z.]

ECTS: 2.0

161 DISEASES OF FARMED AQUATIC ANIMALS LECTURES 1st hour Diseases of fish due to environmental factors. Metabolic and nutritional disorders. Histological findings 2nd hour Viral diseases of fish (Viral Haemorrhagic Septicaemia, Infectious Pancreatic Necrosis, Infectious Haemorrhagic Necrosis, Spring Viraemia of Carp). Histological findings 3rd hour Viral diseases of fish (Viral Nervous Necrosis, Lymphocystis, Fish Pox, Emerging viral diseases of marine species). Histological findings 4th hour Bacterial diseases of fish (pathological conditions due to myxobacteria, Edwarsiellosis, Streptococcosis, Bacterial Kidney Disease, infections due to acid‐fast bacteria, Carp Erythrodermatitis, Mycobacteriosis, Nocardiosis). Histological findings 5th hour Bacterial diseases of fish (Red Mouth Disease, diseases due to Pseudomonas spp. and Aeromonas spp., Furunculosis, Columnaris Disease, Cold Water Disease, Bacterial Gill Disease, Ricketsiosis, Chlamidiosis. Emerging bacterial diseases of marine species). Histological findings 6th hour Bacterial diseases of fish (Vibriosis, Pasteurellosis). Histological findings 7th hour Fungal diseases of fish. Diseases of Crustaceans. 8th‐9th hour Diseases of fish due to protozoan parasites. Histological findings 10th hour Diseases of fish due to metazoan parasites. Histological findings 11th hour Diseases of bivalves. Methods for shellfish depuration 12th hour Modern methods for diagnosis

PRACTICALS 18 hours

In this course, the theory is included in the 7th semester and the practicals in the 9th and 10th semesters. The attendance of the course ‘Farming and Pathology of Aquatic Organisms’ (7th III Module) is suggested.

Minimum required number of enrolled students: 5 Maximum allowable number of enrolled students: 30

Instructors: P. Angelidis [P.A.], I. Vatsos [I.V.]

ECTS: 2.5

162 ENTREPRENEURSHIP AND INNOVATION

The course is organized into four basic sections: lectures (7 weeks * 3 hours = 21 hours), exercises‐laboratories (4 weeks * 3 hours = 12 hours), educational visits to enterprise units (2 weeks) and development of Business Plan.

LECTURES In this section, which lasts seven (7) weeks, the necessary knowledge is provided for the foundation, operation and management of a small‐ or medium‐sized enterprise. Additionally, the appropriate psychological and knowledge background for the development and the expression of entrepreneurship, in general, are established. More specifically:

1st – 3rd hour Modern labor market (characteristics, tendencies), small‐medium sized enterprises, entrepreneurship. Characteristics of a candidate businessman/ businesswoman. External ‐ internal motivation for the development of entrepreneurial initiative. 4th – 6th hour Basic principals of management of small‐ or medium‐ sized enterprises. Skills for exercising the functions of management. Structuring environment. 7th – 9th hour Selection of the site and the legal form of the enterprise. Legal requirements for the foundation of the enterprise. Tax and Insurance obligations. 10th – 12th hour Assessment of the external – internal entrepreneurial environment – S.W.O.T. Analysis 13th – 15th hour Economic analysis and structuring of the Accounts Department 16th – 18th hour Investments – Investment financing plan. Operational plan ‐ Business Plan – Presentation of software. 19th – 21st hour Development of Business Plan with the use of business planning software.

EXERCISES‐LABORATORIES In this section, which lasts four (4) weeks, the students will practice in the development of a Business Plan with the use of business planning software or/and virtual enterprises.

EDUCATIONAL VISITS In this section, which lasts two (2) weeks, emphasis is put to the integration of education/theory with the application of the knowledge and to the establishment of substantial contact of the students with the world of business. To this end, two (2) visits at enterprises of veterinary interest (especially small‐ and medium‐ size) are being planned, prepared and implemented or, alternatively, special case studies will be described and analyzed in cooperation with businessmen and/or managers of enterprises or other organizations.

163

DEVELOPMENT OF BUSINESS PLAN The course “Entrepreneurship and Innovation” is completed with the development from the students of a Business Plan, on the development of a new entrepreneurial activity in a sector of Veterinary Medicine of their choice. Students’ evaluation /examination at the end of the semester will be based on their Business Plan.

This course, which includes an examination, is offered during the 7th semester of studies. There is no requirement of previous attendance of any other course.

Maximum number of students: 15

Instructors: Ch. Batzios & Faculty members of the School of Economic Sciences of the Aristotle University of Thessaloniki

ECTS: 3.0

164 COMPARATIVE PATHOLOGY OF NEOPLASIA

LECTURES: 1st–2nd hour: Carcinogenesis. Current concepts in the molecular basis of carcinogenesis. The histopathology of the stages of carcinogenesis 3rd–4th hour: Cell proliferation and neoplasia. Apoptosis and neoplasia. Inflammation and neoplasia. Stem cells and neoplasia. Tumor stroma and neoplasia 5th–6th hour: Animal models of neoplasia‐An Introduction. Types of animal models of neoplasia. Criteria for the selection of appropriate animal models 7th–8th hour: Animal models for the study of alimentary system neoplasia 9th–10th hour: Animal models for the study of mammary and prostate gland neoplasia 11th–12th hour: Animal models for the study of skin and hemopoietic, respiratory and nervous system neoplasia

PRACTICALS:

1st–2nd hour: Necropsies of laboratory animals (mice). Tissue sample collection. Paraffin wax embedding of fixed tissues 3rd–4th hour: Microscopical examination of mouse neoplasms by the students and discussion 5th–6th hour: Histopathological diagnostic technique trainining in the laboratory

This course is examined in the 7th semester of studies. No previous attendance of other courses is obligatory. The previous attendance of the 6th (II) Module of studies is a requirement for enrollment.

Minimum required number of enrolled students: 5 Maximum allowable number of enrolled students: –

Instructor: T. Poutahidis [T.P.]

ECTS: 2

165 DIAGNOSTIC IMAGING

LECTURES 1st hour Radiographic techniques, Radiation safety and safety rules 2nd hour Hip Dysplasia: Screening tests and methods 3rd hour Special radiographic procedures with the use of contrast media 4rd hour Abdominal and thoracic ultrasonography: Principles of interpretation 5th hour New imaging modalities: Computerized tomography and Magnetic resonance imaging (CT, MRI)

PRACTICALS 25 hours

This course is examined in the 8th semester of studies. No previous attendance of other courses is obligatory.

Minimum number of students: 10 Maximum number of students: 25

Instructor: Papadopoulou P. [P.P.], Patsikas M. [M.P.]

ECTS: 2.0

166 HUSBANDRY AND DISEASES OF PRODUCTION ANIMALS: SMALL RUMINANTS LECTURES 1st hour Methods of monitoring health, welfare and production characteristics at farm level. Qualitative and quantitative assessment of production parameters in combination with suggestions for management alterations [G.A.] 2nd hour Recording and monitoring systems in sheep and goat farms according to the farming system and the type of reared animals [G.A.] 3rd hour Planning of annual and monthly preventive measures against problems which are caused by non‐infectious agents in individual farms, but also in groups of farms located in specific geographical areas. Dealing with health problems that are associated with errors in rearing methods [G.A.] 4th hour Planning and application at farm level of biosecurity measures to produce high quality products (e.g. milk, meat) [G.A.] 5th hour Integrated management of the production qualities of sheep and goat to optimize their health and performance. Managerial measures to solve problems related to nutrition, hygiene, etc. [G.A.] 6th‐7th hour Clinical approach and control of chronic wasting diseases in small ruminants [Ν.G.] 8th‐9th hour Clinical approach and control of diseases that cause reduced growth rate in lambs and goat kids [Ν.G.] 10th‐11th hour Investigation and control of sudden death in small Ruminants‐Clinical approach and control of lameness in small ruminants [Ν.G.] 12th‐13th hour Clinical approach and control of nervous diseases in small Ruminants [Ν.G.] 14th‐15th hour Control of ecto‐ and endoparasites. Vaccinnes [Ν.G.]

PRACTICALS

1st‐40th hour Visits to sheep and goat farms with the mobile clinic [G.A., N.G., E.P.] This course is offered at the 8th semester. The previous attendance of the following course: ‘Animal Farming (4th Module module, IV), circulatory, respire‐ tory and urinary system (8th Module module, II), digestive system (8th Module module, III), skin, nervous system, muscular system, various (8th Module, IV) is mandatory. Minimum number of students: 8, Maximum number of students: 16

Instructors: Arsenos G. [G.A.], Giadinis N. [N.G.], Petridou E. [E.P.] ECTS: 4.0

167 FOOD BIOTECHNOLOGY LECTURES 1st hour Introduction to Food Biotechnology. Definitions, history, traditional and modern Food Biotechnology 2nd hour Methods in Food Biotechnology 3rd & 4th hour hour Microorganisms, industrial fermentations, products of industrial fermentation technology 5th hour Industrial Microbiology 6th hour Microbial food production. Production of food additives 7th hour Enzymes and their uses in Food Technology 8th hour Microbial genetics and genetic manipulations of food microorganisms. Products of genetically modified food microorganisms 9th hour Regulatory, safety and social economic issues on Food Biotechnology

PRACTICALS 1st‐3rd hours Instrumentation and methods. Examples of biotechnological applications 4th‐6th hours Fermentation kinetics

Completion of this course requires a written examination. The course belongs to the 8th semester of studies. The previous attendance of the 7th (II) Module of studies is a requirement for enrollment.

Minimum required number of enrolled students: 5 Maximum allowable number of enrolled students: 25

Instructor: Papagianni M. [M.P.] ECTS: 2.0

168 FOOD MICROBIOLOGY LECTURES 1st‐2nd hour Microorganisms in foods of animal origin [Ν.S.] 3rd‐4th hour Factors affecting the survival and growth of microorganisms in foods (Part I) [Ν.S.] 5th‐6th hour Factors affecting the survival and growth of microorganisms in foods (Part II) [Ν.S.] 7th‐8th hour Control of microorganisms in foods. Principles which influence microbial inhibition and death in foods 9th‐10th hour Sources of potential spoilage organisms in foods. Changes in foods caused by spoilage microorganisms and microbial enzymes [Ν.S.] 11th hour Changes affecting the spoiled foods. Indicators of microbial food spoilage [Ν.S.] 12th hour Food microbiology and Public Health [Ε.Ι.] 13th‐14th hour Bacteria associated with foodborne infections and intoxications [Ε.Ι.] 15th hour Viruses and fungi associated with foodborne diseases [Ε.Ι.] 16th hour Parasites associated with foodborne diseases [Ε.Ι.] 17th hour New and emerging foodborne pathogens[Ε.Ι.] 18th hour Sea toxins and foodborne diseases [Ε.Ι.] 19th hour Indicators of bacterial pathogens [Ε.Ι.] 20th‐21st hour Procedure to investigate foodbornes diseases [Ε.Ι.]

PRACTICALS 1st‐6th hr Total mesophilic count, thermophilic, phsychrotrophic counts in foods of animal origin 7th‐12th hr Detection and enumeration of coliforms in foods of animal origin 13th‐18th hr Coagulase positive Staphyloccocci count 19th‐24th hr Detection and identification of Salmonella spp. in foods of animal origin (biochemical, serological methods)

Completion of this course requires a written examination. The course belongs to the 8th semester of studies. The previous attendance of the 7th Module (II, IV) of studies is a requirement for enrollment.

Minimum required number of enrolled students: 5 Maximum allowable number of enrolled students: 16

Instructors: Amin Abrahim, [Αb.Αm.], E. Ιosifidou [Ε.Ι.], D. Sergelidis [D.S.], Ν. Soultos [Ν.S.]

ECTS: 4.0

169 HYGIENE AND TECHNOLOGY OF DAIRY PRODUCTS LECTURES 1st hour Hygiene and technology of sterilised milk (U.H.T. and evaporated), sweetened condensed milk and milk powder. HACCP implementation in the dairy industry [A.A.] 2nd hour Starter cultures. Lactic acid bacteria (LAB). Thermophilic starters. Mesophilic startrers. The preservation and preparation of starter cultures. Factors that inhibit the growth of starters [A.A.] 3rd hour Fermented dairy products. Lactic acid fermentation products. Mesophilic and thermophilic LAB fermentations. The mechanism of yoghurt gelation [A.A.] 4th hour Probiotic dairy products. Lactic and alcoholic fermentation products. Kefir, koumiss, Acidophilus milk. Mold‐lactic fermentation products and condensed milk products [A.A.] 5th hour Packaging, storage and shelf‐life of fermented dairy products. Nutritive value and health benefits of fermented dairy products [A.A.] 6th hour Quality control and defects of fermented dairy products. Regulatory aspects. HACCP implementation in yogurt manufacture [A.A.] 7th hour Methods of manufacture and standardization of milk cream. The major types of cream [D.F.] 8th hour Cream pasteurisation, packaging and preservation. Microbiology and defects of cream. Quality control and regulatory aspects. HACCP implementation in cream manufacture [D.F.] 9th hour Butter. Quality control of the primary ingredients. Production steps during butter manufacture [D.F.] 10th hour Continuous methods of butter manufacture. Alternative methods for the manufacture of cultured butter. Butter coloring. Special types of butter. The packaging and preservation of butter [D.F.] 11th hour Microbiology and defects of butter. Quality control and regulatory aspects. HACCP implementation in butter manufacture. [D. F.] 12th hour Chemical composition of ice cream. Primary ingredients for ice cream manufacture [D.F.] 13th hour Production steps during ice cream manufacture. The microbiology of ice cream [D.F.] 14th hour Defects and quality control of ice cream. Regulatory aspects. HACCP implementation in ice cream manufacture [D.F.] 15th hour Basic ingredients for cheesemaking. Microbiological quality and chemical composition of milk used for cheesemaking.

170 Cheese yield. The use of enzymes, starters, salt and additives for cheesemaking. Regulatory aspects [D.P.] 16th hour Fundamentals of cheesemaking. Cheesemaking operations. Quality control and pasteurization of milk used for cheesemaking. Addition of starters and coagulation of milk. Curd cutting and handling. Cheese salting. Ripening of cheese and methods of accelerated ripening. Ripening mechanisms that lead to cheese safety [D.P.] 17th hour Hygiene aspects in modern industrial cheesemaking systems. Mechanization–automation of production steps. Partially and fully automated systems. Ultrafiltration‐based cheesemaking [D.P.] 18st hour Advanced cheesemaking practice. Cheese classification. The manufacture of unripened cheeses, cheeses ripened with starters (hard, semi‐hard, pasta filata, brined cheeses and mould‐ripened cheeses) [D.P.] 19th hour The Greek P.D.O. cheeses [D.P.] 20th hour HACCP implementation in the production lines of Feta, Kaseri and Kefalotyri P. D. O. cheeses [D.P.] 21st hour Processed cheeses. The utilization of milk whey. Whey‐ cheese manufacture. HACCP implementation in whey‐ cheese manufacture [D.P.] 22nd hour The defects and faults of cheeses. Preventive measures [D.P.] 23rd hour Cheese microbiology. Behavior of pathogenic bacteria during the manufacture and ripening of cheeses. Public health aspects of cheeses [A.A.] 24th hour Cheese quality control. Caseins and caseinates. Regulatory aspects [A.A.]

PRACTICALS [A. A., D. P., D. F.] 1st‐3rd hour Traditional methods of chemical analysis of dairy products. Determination of fat content and total solids in dairy products (cream, butter, cheese, yogurt, etc.) 4th‐6th hour Microbiological analysis of dairy products according to EU Regulations 853/2004 and 2073/2005 – Part I. 7th‐9th hour Microbiological analysis of dairy products according to EU Regulations 853/2004 and 2073/2005 – Part II: Reading, interpretation and reporting of the results 10th‐12th hour The preparation of starter cultures and the manufacture of yoghurt, Feta cheese and whey cheeses 13th‐15th hour The design of thermal processes for milk and dairy products. Implications on dairy product quality and safety 16th‐18th hour HACCP implementation in the manufacture of Feta cheese, whey cheeses, yoghurt and other dairy products (in‐class exercise) 19th‐21st hour Training visit in a dairy processing plant

171 22nd‐24th hour Training visit in a dairy processing plant, or visit to the Central and Western Macedonia Milk Quality Control Laboratory

Completion of this course requires a written examination. The course belongs to the 8th semester of studies. The previous attendance of the 7th (I) Module of studies is a requirement for enrollment.

Minimum required number of enrolled students: 5 Maximum allowable number of enrolled students: 45

Instructors: Angelidis, A. [A. A.], Papageorgiou, D. [D. P.], Fletouris, D. [D. F.]

ECTS: 4.5

172 FOOD TOXICOLOGY

LECTURES 1st hour Introduction to food toxicology. Toxicants in foods of animal origin, human health aspects, acceptable daily intake (ADI), maximum residue limit (MRL), withdrawal period (WP). [D.F.] 2nd hour Incidence of veterinary drug residues in foods of animal origin. Frequently implicated classes of veterinary drugs. Sources of contamination and monitoring of foods for drug residues. [D.F.] 3rd hour Problems in the food industry and human health aspects related to veterinary drug residues. [D.F.] 4th hour Stability of veterinary drug residues during food storage and processing. Legislation. [D.F.] 5th hour Toxic compounds formed during production, processing, preservation and storage of foods. Polycyclic aromatic hydrocarbons: Classification, formation, ways of food contamination. Legal aspects. [A.P.] 6th hour Nitrosamines and heterocyclic amines: Classification, formation, ways of food contamination. [A.P.] 7th hour Heavy metals: Cadmium, lead, arsenic, mercury. Incidence in food of animal origin. Fish contamination with methyl mercury. [A.P.] 8th hour Migration of toxic compounds from food contact materials to foods. Legal aspects. Food allergies: Foods involved in triggering them. Major allergens in foods of animal origin. [A.P.] 9th hour Risk analysis of chemical hazards [E.P.] 10th hour Pesticides residues in foods of animal origin. Human health effects. Legislation [E.P.] 11th hour Marine biotoxins in bivalve molluscs. Human health effects. Legislation. [E.P.] 12th hour Dioxins in foods of animal origin. Human health effects. Legislation. [E.P.]

PRACTICALS 1st‐3rd hour Rapid methods for the determination of chemical contaminants in foods of animal origin. 4th‐6th hour Current analytical methods for the determination of chemical contaminants in foods of animal origin (HPLC, GLC).

Completion of the course requires a written examination. The course belongs to the 8th semester of studies. The previous attendance of the 7th (I) and 7th (II) Modules of studies is a requirement for enrollment. Minimum number of students: 5 Maximum number of students: 25

Instructors : A. Papavergou [A.P.], E. Papapanagiotou [E.P.], D. Fletouris [D.F.]

ECTS: 2.0

173 MANAGEMENT INTERVENTIONS FOR THE IMPROVEMENT OF REPRODUCTIVE PARAMETERS AND THE UDDER HEALTH IN FARMS OF PRODUCTION ANIMALS

LECTURES 1st hour Introduction in the reproductive management [C.Bo.] 2nd hour Approach to the reproductive management in farms of productive animals [C.Br.] 3rd–5th hour Management of problems of udder of ruminants at the farm level. Diagnosis, confrontation and prevention of problems of mastitis in modern farms of ruminants [E.K, C.Br.] 6th–8th hour Collection and evaluation of data for the improvement of the reproductive performance in the farms of productive animals [E.K., C.Br.] 9th–10th hour Management of newborn. Diagnosis, confrontation and prevention of diseases of newborn in farms of productive animals [C.Bo., C.Br.]

PRACTICALS 24 hours

Approach and analysis of problems of reproduction in farms, confrontation of incidents, application of reproductive management, diagnosis, confrontation and prevention of problems of udder of ruminants in modern farms. Exploitation of parameters that are related with the milking and milking parlor.

The course is included in the 9th semester. The previous follow‐up of Modules 8th (II) and 8th (III) is compulsory.

Minimum required number of enrolled students: 4 Maximum allowable number of enrolled students: 10

Instructors: Kiossis E. [E.K], Boscos C. [C.Bo.], Brozos C. [C.Br.]

ECTS: 2.5

174 HUSBANTRY AND MEDICINE OF PRODUCTION ANIMALS: CATTLE

LECTURES 1st hour Methods of monitoring health, welfare and production characteristics at farm level. Qualitative and quantitative assessment of production parameters in combination with suggestions for management alterations [G.A., G.V.] 2nd hour Planning of annual and monthly preventive measures against problems which are caused by non‐infectious agents in individual farms, but also in groups of farms located in specific geographical areas. Dealing with health problems that are associated with errors in rearing methods [G.A., G.V.] 3rd hour Planning and application at farm level of biosecurity measuresto produce high quality products (e.g. milk, meat). Managerial measures to solve problems related to nutrition, hygiene, etc. [G.A., G.B.] 4th‐6th hour Main diseases of dairy cattle, clinical approach and control [Ni.P.] 7th‐8th hour Main diseases of feed lot cattle: clinical approach and control [H.K.] 9th‐10th hour Selection and application of vaccine programs in beef and dairy herds [H.K., Ni.P.]

PRACTICALS

1st‐40th hour Visits to dairy cow and beef cattle farms with the mobile clinic [G.A., G.V., H.Κ., Ni.P.]

The course is included in the 9th semester. The previous follow‐up of Cources 4th (IV), 8th (IΙ), 8th (IΙΙ) and 8th (IV) is compulsory.

Minimum required number of enrolled students: 8 Maximum allowable number of enrolled students: 16

Instructors: Arsenos G. [G.A.], Valergakis G. [G.V.], Karatzias H. [H.Κ.], Panousis Ν. [Ni.P.]

ECTS: 3.5

175 SMALL ANIMAL MEDICINE I LECTURES 1st hour Basic principles of behavioural therapy in companion animals [Al.K.] 2nd hour Separation anxiety [Al.K.] 3rd hour Obsessive‐compulsive disorders [Al.K.] 4th hour Aggression [Z.P.] 5th hour Changes in normal behavioural patterns, phobias [Z.P.] 6th hour The most common neurological diseases of cats [Al.K.] 7th hour Management of chronic otitis externa and media in the dog [Al.K.] 8th hour Diagnostic aproach of symmetric feline alopecia [Al.K.] 9th hour Diagnostic approach of feline miliary dermatitis and eosinophilic granuloma complex [Al.K.] 10th hour Diagnostic approach of canine diffuse alopecia [Al.K.] 11th hour Short and long term management of congestive heart failure in the dog and cat [Ch.K.] 12th hour Diagnostic approach of canine diffuse neuromuscular diseases [Z.P.]

PRACTICALS 38 hours

This course is examined in the 9th semester of studies. Previous attendance of related subjects of Cardiology, Dermatology and Neurology, taught in the 8th Module (II and IV) is obligatory.

Minimum number of students: 10 Maximum number of students: 25

Instructors: Koutinas Al. [Al.K.], Koutinas Ch. [Ch.K.], Polizopoulou Z. [Z.P.]

ECTS:3.5

176 FOOD SAFETY AND FOOD INSPECTION IN PRACTICE (REGULATIONS AND THE ROLE OF THE VETERINARIAN). FISH PROCESSING TECHNOLOGY. PACKAGING FOR FOOD OF ANIMAL ORIGIN

LECTURES 1st‐3rd hour Food inspection in practice [Ι.Α.] 4th‐5th hour The role of the veterinarian in food inspection according to the relative law [I.A.] 6th‐7th hour Packaging for food of animal origin. Basic principles and packaging materials [Α.P] 8th hour Chemical composition of fish flesh. Biochemical dynamics and nutritive value of fish. Quality of fresh fish. Methods of preservation of fish: Chilling and freezing of fish. Preservation of fish by curing (salting, smoking). Quality and quality assurance of preserved fish products [Μ.P.] 9th hour Processing technologies of low value fish. Quality control and assurance of surimi‐based products [Μ.P.] 10th hour Fishery by‐products. Major production processes and biotechnological processing of raw materials. Safety issues [Μ.P.] PRACTICALS 1st‐3rd hour The role of the veterinarian according to regulations 170/2002 and 852/2004 4th‐6th hour Implementation of food inspection. Regulations 853/2004, 854/2004, 882/2004 and 1441/2007 7th‐9th hour Case studies on food inspection 10th‐12th hour Exercises in food packaging 13th‐15th hour Assessment of fish quality. Sensory and non‐sensory methods for determining quality 16th‐18th hour Smoked fish: Production technology, processing, quality 19th‐21st hour Surimi and fish mince products: The surimi process and quality of surimi products

Completion of this course requires a written examination. The course belongs to the 9th semester of studies. The previous attendance of the 7th Module (II, III) is a requirement for enrollment.

Minimum required number of enrolled students: 5 Maximum allowable number of enrolled students: 25

Instructors: Ambrosiadis I. [Ι.Α.], Ζetou F. [F.Z.], Papavergou A. [A.P.], Papagianni M. [M.P.] ECTS: 2.5

177 HYGIENE OF FOODS OF ANIMAL ORIGIN HACCP SYSTEM DEVELOPMENT AND IMPLEMENTATION IN FOOD ESTABLISHMENTS STRUCTURE AND OPERATION OF PROCESSING UNITS OF PRODUCTS OF ANIMAL ORIGIN LECTURES 1st‐3rd hour Microbiology of poultry meat and eggs. Modes of infection. Factors affecting the contamination of poultry meat and eggs [P.K.] 4th‐5th hour Products from poultry meat and eggs. Production stages. Microbiology, lesions, preservation, implementation of hazard analysis systems (HACCP). Regulatory Aspects [P.K.] 6th‐7th hour Identification of seafood. Microbiology, factors affecting the hygiene status of seafood [Ab.Am.] 8th‐9th hour Hygiene of preserved seafood. Hygiene of ready‐to‐eat foods [Ab.Am.] 10th hour Implementation of hazard analysis systems in a seafood production unit [Ab.Am.] 11th‐12th hour Development and implementation of food safety management system (FSMS) according to EN ISO 22000‐ 2005. Introduction, Scope, conditions and definitions, general requirements [Ι.Α., D.S.] 13th‐14th hour Validation requirements, administration responsibility, resources management, design and production of safe products (prerequisites, preliminary steps) [D.S.] 15th‐16th hour Design and implementation of safe products (hazard analysis, establishment of prerequisite programmes, establishment of HACCP plan, traceability system, non compliance check) [D.S.] 17th‐18th hour Hazard analysis of different food categories. Hazard control measures. The “hurdles” theory [Ι.Α.] 19th‐20th hour Certification, verification and improvement of FSMS[D.S.] Control of FSMS (auditing) [Ι.Α.]

PRACTICALS 1st‐14th hour Training in meat inspection in slaughterhouses. On‐site assessment of food processing establishments (practical exercises in processing establishments of food of animal origin) 15th‐16th hour Implementation and on‐site assessment of HACCP system in foodservices (restaurants and catering) 17th‐18th hour Implementation and on‐site assessment of HACCP system in meat processing establishment 19st‐20th hour Implementation and on‐site assessment of HACCP system in pig slaughterhouse 21st ‐22nd hour Licensing terms for establishing and operating of processing establishments of foods of animal origin

178

Completion of this course requires a written examination. The course belongs to the 9th semester of studies. The previous attendance of the 7th (II, IV) Modules is a requirement for enrollment.

Minimum required number of enrolled students: 5 Maximum allowable number of enrolled students: 25

Instructors: Αmbrosiadis I. [Ι.Α.], Amin Ab. [Αb. Αm.], Ιosifidou E. [Ε.Ι.], Κoidis P. [P.Κ.], Papanagiotou E. [E.P.], Sergelidis D. [D.S.], Soultos Ν. [Ν.S.]

ECTS: 4.0

179 SMALL ANIMAL ANAESTHESIA AND INTENSIVE CARE I&II

LECTURES 1st hour Principles of applied respiratory physiology. Muscle relaxation 2nd hour Support of respiratory system 3rd hour Principles of applied cardiovascular physiology 4th hour Support of cardiovascular system 5th hour Support of renal function. Electrolyte imbalance 6th hour Acid/base balance 7th hour Metabolism in critical illness. Nutritional support and glucose homeostasis 8th hour Total intravenous anaesthesia (TIVA) 9th hour Breathing circuits 10th hour Reperfusion injury syndrome 11th hour Systemic inflammatory response syndrome (SIRS) 12th hour Shock

PRACTICALS 38 hours

This course is taught in the 9th and 10th semesters. Previous attendance of the subject "Anaesthesia and Intensive Care", which is included in the 8th Module (IV, section 1), is obligatory. Final assessment will be based on grading student performan‐ce in the clinic and quality of an oral presentation or study in the pertinent field.

Minimum number of students per study period: 1 Maximum number of students per study period: 6

Instructors: T. Anagnostou .][T.A , G. Kazakos [G.K.], D. Raptopoulos [D.R.], I. Savvas [I.S.]

ECTS: 4.0

180 SMALL ANIMAL OBSTETRICS I &II LECTURES

1st hour Ovariohysterectomy. Technique adaptation to the stage of the ovarian cycle and to the genital system disorder 2nd hour Dystocia: diagnostic and therapeutic approach 3rd hour Advanced cytology of the genital system of the dog 4th hour The usefulness of hormonal measurements (progesterone, relaxine, LH) in the diagnostics of dog genital system disorders

PRACTICALS 46 hours

This course takes place during the 9th and 10th semester of the curriculum and it is followed by a final examination. The previous attendance of the subject “Obstetrics and reproductive disorders of the female dog and cat”‐ (6th semester, 8th II Module) is obligatory. The final grade will be based on 1) the assessment of the student’s every day ‐ performance (60%) and on 2) the final examination (40%), concerning the respectively observed cases, theory lessons and when appropriate, the student’s performance to edit a short retrospective study or a clinical case report.

Minimum number of students: 1 Maximum number of students: 8

Instructor: Ververidis H. [H.V.]

ECTS:3.5

181 SMALL ANIMAL DENTISTRY I & II

LECTURES

1st hr Organization of dental practice, management of dental instruments, equipment and materials 2nd hr Anatomy, histology and physiology of the teeth and jaws 3rd hr Clinical examination of the mouth, the jaws and teeth, dental records 4th hr Periodontal disease, special therapies 5th hr Dog and cat teeth surgical extraction

PRACTICALS 45 hours

This course is taught in the 9th and 10th semester of studies. In each semester the course comprises of two study periods, five (5) days each. A student may follow one or more study periods. Previous attendance of the courses related to the relevant subjects of the 8th Module (III and IV) is obligatory. Final assessment will be based on grading student performance in the clinic and quality of an oral presentation or study in the pertinent field.

Minimum number of students per semester: 1 Maximum number of students per semester: 6

Instructor: S. Papadimitriou [S.P.]

ECTS:3.5

182 SMALL ANIMAL SOFT TISSUE SURGERY I &II

LECTURES

None

PRACTICALS 50 hours

This course is taught in the 9th and 10th semester. It comprises of two study periods, five (5weeks each). A student may follow one or two study periods. Previous attendance of related subjects of the 8th Module (I,II,II,IV) is obligatory.

Maximum number of students per period: 6

Instructors: Papazoglou L. [L.P.], Karagianopoulou M. [M.Ka.]

ECTS: 3.5

183 CANINE & FELINE ORTHOPAEDICS AND NEUROSURGERY I &II

LECTURES

1st hour Orthopaedic instruments and implants [Ν.Pr.] 2nd hour Diagnostic procedures of the musculoskeletal system [Ν.Pr.] 3rd hour Bandages, splints and casts [Ν.Pr.] 4th hour Osteoarthritis [Ν.Pr.] 5th hour Surgical approaches to the bones and joints [Ν.Pr.] 6th hour Physiotherapy [Ν.Pr.] 7th hour Orthopaedic variations between dog and cat [Ν.Pr.] 8th hour Differential diagnosis of forelimb lameness [Ν.Pr.] 9th hour Differential diagnosis of hindlimb lameness [Ν.Pr.] 10th hour Self‐assessment in orthopaedic problems [Ν.Pr.] 11th hour Thoracolumbar spine surgery [G.K.] 12th hour Cervical spine surgery [G.K.]

PRACTICALS 38 hours

This course is included in the 9th and 10th semester of studies. It comprises of one study period of ten (10) days. Previous attendance of the subjects of the 8th Module (I) and the 1st and 3rd sections of the 8th (IV) Module as well, are obligatory. Final assessment will be based on grading student performance in the clinic and quality of an oral presentation or study in the pertinent field.

Minimum number of students: 1 Maximum number of students: 6

Instructors: N. Prassinos [N.Pr.], G. Kazakos [G.K.], G. Tsimopoulos [G.Ts.]

ECTS:4.0

184

ΟPHTHALMOLOGY I&II

113BLECTURES

1st hour Diseases of the Conjunctiva. (In the dog and cat). Ocular discharge. Εpiphora. Abnormal ocular discharge. Conjunctivitis. Keratoconjunctivitis sicca 2nd hour Diseases of the Cornea (in the dog). Corneal dystrophy. Corneal ulcers. Keratitis. Chronic superficial keratitis (CSK) or “Pannus”. Pigmentary keratitis 3rd hour Diseases of the Cornea (in the cat). Feline eosinophilic keratitis. Corneal sequestration. Feline herpesvirus keratitis 4th hour Diseases of the Uvea (in the dog and cat). Uveitis 5th hour Diseases of the Lens (in the dog and cat) Cataract. Lens luxation 6th hour Glaucoma. Buphthalmos. Exophthalmos. (in the dog and cat) 7rd hour Diseases of the Retina (in the dog and cat). Retinal Dysplasia. Retinal Degeneration/Atrophy. Chorioretinitis. Retinal detachment. Optic neuritis 8th hour Surgery of the eyelids (in the dog and cat). Eyelid lacerations. Entropion. Ectropion. Prolapse of the third eyelid gland. Tarsorrhaphy. Conjunctival flaps and grafts 9th hour Surgery of the cornea. Corneal lacerations and corneal grafts. Superficial keratectomy (in the dog and cat) 10th hour Ocular therapeutics (in the dog and cat)

PRACTICALS 40 hours

This course is taught in the 9th and 10th semester of studies. It comprises of one study period of ten (10) days. The final mark is based on both written (30%) and practical (70%) examinations.

Maximum number of students: 1 Maximum number of students: 6

Instructor: Komnenou A. [An.K.]

ECTS:4.0

185 EQUINE SURGERY, MEDICINE AND OBSTETRICS I&II

121BLECTURES 1st hour Epiphysitis. Osteochondrosis. Angular limb deformities. Flexural limb deformities 2nd hour Muscle trauma. Bruising of the hoof. Hoof abscessation. Quittor. Sidebone 3rd hour Carpal canal syndrome. Curb 4th hour Upward fixation of the patella. Subluxation of the cervical vertebrae. Overgranulation tissue 5th hour Methods of treatment: hydrotherapy, diathermy, ultrasound, electromagnetic fields, laser therapy, chiropraxy, swimming, exercise, radiation therapy, acupuncture, counterirritation 6th hour Atrial fibrillation, anaemia of the chronic inflammatory disease, lymphagitis 7th hour Physiology of reproduction, oestrus cycle, irregular oestrus cycles, hormonal interventions 8th hour Ovarian disease (delayed ovulation, ovarian cystic, follicle persistent, inactive ovaries) 9th hour Uterus disease (endometritis) 10th hour Uterus disease (endometrial cysts, tumors)

PRACTICALS 40 hours

This course is taught in the 9th and 10th semester of studies. It comprises of one study period of ten (10) days. Previous attendance of related subjects of the 8th Module (I, II, III and IV) is obligatory.

Number of students: 3‐6

Instructors: Diakakis N. [N.D.], Kiossis E. [E.K.]

ECTS: 4.0

186 BIOTECHNOLOGY AND MODERN METHODS OF CONFRONTATION OF REPRODUCTIVE PROBLEMS AND THE UDDER HEALTH IN FARMS OF PRODUCTION ANIMALS LECTURES 1st–4th hour Biotechnology and modern methods of reproduction in productive animals [C.Bo., C.Br.] 5th–6th hour Modern methods of diagnosis and treatment of udder and teats diseases of dairy cows [E.K.] 7th‐8th hour Prevention of post partum diseases of dairy cows [C.Bo., C.Br.] 9th‐10th hour Use ultrasound in reproduction [E.K.]

PRACTICALS 24 hours

Organisation and operation of a biotechnology laboratory, demonstration and application of modern methods of management of gametes, embryo tranfer, special techniques of insemination, demonstration and application of modern methods of confrontation of udder and teat diseases of dairy cows, demonstra‐ tion and applications of ultrasound machine in the reproduction.

The course is included in the 10th semester. The previous attendance of Modules 8th (II) and 8th (III) is compulsory.

Minimum number of students: 4 Maximum number of students: 10

Instructors: Kiossis E. [E.K.], Boscos C. [C.Bo.], Brozos C. [C.Br.]

ECTS: 2.5

187 HUSBANTRY AND MEDICINE OF PRODUCTION ANIMALS: SWINE LECTURES 1st hour Production indices in modern pig farming (production goals). Quantitative and qualitative evaluation and management in farm level [P.F., S.K., E.Tz.] 2nd hour Prevention and management of pig diseases caused from non‐infectious agents. Control of health problems associated with environmental factors and breeding management factors [P.F., S.K., E.Tz.] 3rd‐4th hour On farm implementation of control and preventive measures against the main digestive disorders and diseases of swine [Ε.Τz., S.K., P.F.] 5th‐6th hour On farm implementation of control and preventive measures against the main respiratory disorders and diseases of swine [Ε.Τz., S.K., P.F.]

PRACTICALS 1st‐40th hour Visits to pig farms with the mobile clinic [P.F., Ε.Τz., S.K.]

The course is included in the 10th semester. The previous follow‐up of Modules 4th (IΙΙ), 8th (IΙ), 8th (IΙΙ), and 8th (IV) is compulsory.

Minimum number of students: 8 Maximum number of students: 16

Instructors: Fortomaris P. [P.F.], Kritas S. [S.K.], Tzika Ε. [Ε.Τz.]

ECTS: 3.0

188 SMALL ANIMAL MEDICINE II LECTURES 1st‐2nd hour The medical management of canine and feline diabetes mellitus and canine hyperadrenocorticism (Cushing’s disease) [N.S.] 3nd hour Feline hyperthyroidism. Endocrinologic emergencies [N.S.] 4th hour Diagnostic approach of canine liver diseases [T.R.] 5th hour Diagnostic approach of chronic enteropathies of the dog and cat [T.R.] 6th hour Diagnostic approach of chronic vomiting in the dog and cat [T.R.] 7th hour Feline idiopathic cystitis [K.A.‐M.] 8th hour The dyspneic dog and cat [K.A.‐M.] 9th hour The medical management of chronic renal failure in the cat [Ch.K.] 10th hour The diagnostic approach and medical management of bleeding disorders in the dog [M.M.] 11th hour Diagnostic approach of anemia in the dog and cat [M.M.] 12th hour Cytology‐guided diagnostic approach of the most common canine neoplasms [M.M.]

PRACTICALS 38 hours

This course is examined in the 10th semester of studies. Previous attendance of related subjects of Hematopoietic System disorders‐Clinical Oncology, Respiratory Diseases of the Dog and Cat, Kidney, Lower Urinary Tract and Prostatic diseases of the Dog and Cat, Gastroenterology and Clinical Endocrinology of the Dog and Cat, taught in the 8th Module (II, III and IV) is obligatory.

Minimum number of students: 10 Maximum number of students: 25

Instructors: Adamama‐Moraitou K. [K.A.‐M.], Koutinas Ch. [Ch.K.], Mylonakis M. [M.M.], Rallis T. [T.R.], Soubasis N. [N.S.]

ECTS: 3.5

189 AVIAN MEDICINE LECTURES 1st hour Clinical examination and treatments, samples collection and autopsy of pet birds 2nd–3rd hour Diseases of pet birds 4th hour Clinical examination and treatments, samples collection and autopsy of wild birds 5th–6th hourDiseases of wild birds 7th hour Vaccination regimens of poultry 8th hour Clinical examination and treatments, samples collection and autopsy of ostriches 9th hour Nutritional, bacterial and viral diseases of ostriches 10th hour Parasitic and fungal diseases of ostriches 11th hour Multi‐factorial gastric diseases, miscellaneous conditions in ostriches 12th hour Αntimicrobials and antiparasitic agents in ostriches. Poisoning

PRACTICALS 30 hours

This course is examined in the 10th semester of studies. Previous attendance of the courses related to “Infectious and Parasitic diseases” taught in the 6th Module, I and II, Pathology (Module 6th ΙΙΙ) and Avian Medicine (Module 8th IV) is obligatory.

Minimum number of students: 5 Maximum number of students: 10

Instructors: Georgopoulou I. [I.G.]

ECTS: 3.0

190