Index

Abattoirs, tumor surveys on animals from, 823, Abruptio placentae, etiology of, 667 828 Abscess( es) Abdomen from endometritis, 249 ectopic pregnancy in, 6 5 1 in leiomyomata, 305 endometriosis of, 405 ovarian, 352, 387, 388-391 enlargement of, from intravenous tuboovarian, 347, 349, 360, 388-390 leiomyomatosis, 309 Acantholysis, of , 26 Abdominal ostium, 6 Acatalasemia, prenatal diagnosis of, 714 Abortion, 691-697 Accessory , 366 actinomycosis following, 129 Acetic acid, use in cervical colposcopy, 166-167 as precursor, 708 "Acetic acid test," in colposcopy, 167 criminal, 695 N-Aceryl-a-D-glucosamidase, in prenatal diagnosis, definition of, 691 718 of ectopic pregnancy, 650-653 Acid lipase, in prenatal diagnosis, 718 endometrial biopsy for, 246-247 Acid phosphatase in endometrial epithelium, 238, endometritis following, 250-252, 254 240 fetal abnormalities in, 655 in prenatal diagnosis, 716 habitual, 694-695 Acridine orange fluorescence test, for cervical from herpesvirus infections, 128 neoplasia, 168 of hydatidiform mole, 699-700 Acrochordon, of vulva, 31 induced, 695-697 Actinomycin D from leiomyomata, 300, 737 in therapy of missed, 695, 702 choriocarcinoma, 709 tissue studies of, 789-794 , 53 7 monosomy X and, 433 endodermal sinus tumors, 545 after radiation for , 188 Actinomycosis, 25 spontaneous, 691-694 of , 129, 130 pathologic ova in, 702 of , 257 preceding choriocarcinoma, 705 of , 352 tissue studies of, 789-794 of ovary, 390, 391 threatened, 694 of , 2 57 tissue studies of, 789-794 Actinomycosis israeli, 129, 352, 391 types of, 691 Addison's disease, premature ovarian failure in, 742

863 Index

Adenocanthomas Adenomyosis, 312-315, 405 ectopic tissue of, in ovarian , 589 in animals, 811, 814, 815, 841 in animals, 810 tumors of, Sertoli-Leydig cell tumors and, 517 of endometrium, 281, 290, 292 clinical aspects of, 312-313 Adrenarche, effect on external genitalia, 13 of fallopian tube, 361 conditions associated with, 314-315 ,8-Adrenergic receptor stimulants, leiomyoma of ovary, 479, 481, 482 gross appearance of, 313 induction by, 801 Adenocarcinofibroma, of ovary, 468 histogenesis, 314 Adrenogenital syndrome, 402 Adenocarcinoma( s) leiomyomata and, 300, 301 as cause of pseudohermaphroditism, 10, 16 in animals microscopy of, 313-314 prenatal detection of, 714 induced, 801, 809, 810, 811, 812, 814, 815 of , 353, 774 African lymphoma, see Burkitt's lymphoma spontaneous, 809, 824-831, 834, 836, 841, Adenosarcomas, experimental induction of, in AG-4 antibody, in cervical cancer detection, 187 845, 849, 853, 856 animals, 804 Agouti, genital tract tumors in, 827, 837 of Bartholin gland, 46, 51 Adenosis, of vagina, after DES exposure, 100 Albinism, of vulva, 35 of breast, Paget's disease in, 44-45 Adenosquamous carcinoma Alcian blue stain in cervical endometriosis, 141 of cervix, 190, 196 for mast cells, 301 of cervix, 70, 87-101, 122, 139, 180, 189-196 of endometrium, 292-294 for mucin, 27, 190, 296 cytology, 760-761 of fallopian tube, 361 Aldosteronism, with ovarian neoplasms, 587 differential diagnosis, 125, 126, 131, 133, in mixed mesodermal tumors, 554 Alkaline phosphatase 134, 140 Adenovirus infection, cytological identification of, in dysgerminomas, 532 in polyps, 132 755 in endometrial epithelium, 238-240 cytological detection of, 764-766 Adenyl cyclase, in endometrium, estradiol effects in irradiated cervical cells, 198 of endocervix, 761 on, 241-242 method using, in embryological studies, 1 in endometrial polyp, 2 59 Adhesions stains for, in spiral arteriole studies, 214 of endometrium, 198-199, 202, 270, 276, 278- amniochorionic, 784-786 Alky lacing agents 292, 761 from endometriosis, 409 cytological effects of, 763 cytology, 764 infertility from, 739, 740-741 in ovarian cystadenoma therapy, 472 of fallopian tube, 359-361 tubal, in endosalpingiosis, 355 Allantois, 1, 2 cytology, 765-766 Adipic acid, vaginal lesions induced by, 813 Alloisoleucine, in prenatal detection, 717 metastases of, 51 Adipose tissue, in myometrial mesodermal tumors, Alsatian dog, ovarian tumors in, 849, 850, 851, in mixed mesodermal tumor, 554, 560 316, 317 853 of ovary, 414 Adolescents Alveolar-glandular pattern, of endodermal sinus from prenatal exposure to DES, 87-101, 813 in, 594-595 tumors, 542 with sarcoma, 323, 336. (See also Mullerian clear cell adenocarcinomas in, 88 Amebiasis, of cervix, 129 tumors) dysgerminomas in, 529, 589-592 Ameboid movement, of primordial germ cells, 2 tuberculous salpingitis and, 351 embryonal carcinomas in, 592-593 Amenorrhea of vagina, 87-101, 813 endodermal sinus tumors in, 539, 594 in Asherman's syndrome, 256 of vulva, 31, 32, 51 epithelial neoplasms in, 606-611 in congenital adrenal , 448 Adenofibroma. (See also Adenomyomas, external genitalia changes in, 13-14 from dysgerminomas, 5 29 Lymphangiomas) Leydig (hilus) cell tumors in, 615 (!estrogen carcinoma" with, 276 papillary malignant lymphomas in, 616-619 after oral contraceptive use, 262 of cervix, 131, 139-140 ovarian cysts in, 618-621 from premature ovarian failure, 741-742 of ovary, 454, 455, 467-469 ovarian tumors in, 586-626 from Sertoli-Leydig cell tumors, 517 Adenofibromyomas in animals, 810 ovary of, 384, 398, 779 in Stein-Leventhal syndrome, 399, 401 Adenoid cystic carcinoma, of cervix, 190, 196-197 sarcomas in, 616-617 in tuberculous endometritis, 256 "Adenoma malignum," of cervix, 191-193 sclerosing stromal tumors in, 614, 615 vaginal smear cytology of, 769-770 Adenomas, in animals, 806, 809, 824, 828, 831, tumors in, 613 X-chromosome abnormalities in, 438, 440-442 833, 835, 836, 838, 846, 853 Sertoli-Leydig cell tumor in, 615-616 Amino acids, errors of metabolism of, prenatal Adenomatoid tumors. (See also Lymphangioma) sex cord-stromal tumors in, 611-616 diagnosis, 713-718 of ovary, 454, 497 teratoblastomas in, 592-593 Aminoazotolune, ovarian tumor induction by, in ~~Adenomatosis," see Adenosis teratocarcinomas in, 595-597 animals, 801 Adenomatous hyperplasia, 265, 267-271, 282, 286 in, 552-553, 554, 597-600 Ammonia, in prenatal diagnosis, 716 in animals, 825 in, 613-614 Amniocentesis, 656, 711 arypical, 270, 273 Adrenal cortex, hyperactivity of, animal tumors early, 713-718 as carcinoma precursor, 267 and, 810 predelivery, 718-724 Adenomyomata Adrenal cortical hyperplasia technique of, 712 adenomyosis and, 313 congenital, pseudohermaphroditism and, Amniochorionic adhesions, gross examination of, in animals, 827 447-448 784-786 of cervix, 131, 140 endocrine disorders from, 402 Amniochorionic roll, for fetal membrane experimental induction of, in animals, 802 endometrial carcinoma and, 279 sectioning, 788 of fallopian tube, 356 male pseudohermaphroditism and, 447 Amniography, of hydatidiform mole, 703 occurrence of, 307 Adrenal gland Amnion

864 Index

bacterial infections of, 659, 660 prenatal detection of, 713 of vagina, 61 formation of, 639, 655 Angiokeratoma, of vulva, 29 Arteriography, of hydatidiform mole, 703 nodosum, 656, 658, 659, 786 Angiomyolipoma, of , 316 Arylsulfatase A, in prenatal diagnosis, 717 rupture of, fetal abnormalities and, 656 Angiomyomas, 306 Ascaris lumbricoides, in cervico-vaginal smears, 755 Amnion bands, fetal abnormalities and, 656 Angiosarcomas Ascites Amnion cells, 656 hemangiopericytomas and, 311 from , 592 Amniotic fluid of uterus, 323 from granulosa cell tumors, 612 abnormalities of, 656 of vulva, 51 from ovarian tumors, 587 biochemical assays of, 710-733 Angora rabbits, genital tract tumors in, 832 Asherman's syndrome indications for, 711 Animal models, for ovarian and uterine tumors, endometritis in, 254, 256 interferences in, 712 797-82'1 infertility from, 737 sample handling in, 712 Animals. (See also individual animals) Aspartic amino transferase, in endometrial time dependent factors in, 711-712 genital tract tumors in, 797-861 epithelium, 238 creatine phosphokinase in, as fetal death Annular tubules, in sex cord tumors, 524, 574 Aspergillus, endometrial infection by, 256 indicator, 712-713 Anovulation "Atherosis" lesions, in abnormal uteroplacental embolism from, 662 dysfunctional uterine bleeding from, 261-262 vasculature, 687-688 leakage of, in placental abnormalities, 664 endometrial hyperplasia from, 265, 266 Atrophic vulvitis, 36 origin of, 711 Antelope, genital tract tumors in, 827 Auspitz sign, in psoriasis, 26 volume of, 712 Antibodies Autoimmunity, in premature ovarian failure, Amniotic sac, distension by water, for gross autoimmunity from, in premature ovarian 741-742 inspection, 785 failure, 742 Autosomal chromosomes, abnormalities of, 440- Amnionitis, causes and effects of, 659 to sperm 442 Ampulla, of fallopian tube, 341, 342 infertility from, 735 Axilla, endometriosis of, 405 Amylo-1,6-glucosidase from schistosomiasis, 129 Azygous artery, 61 in cervical parabasal cells, 104 Antigen TJ a, habitual abortion and, 692 in prenatal diagnosis, 715 Antigens, cervical stimulation by, 110 Anaerobic glycolysis Aortic lymph nodes, 368, 369 Backache, from cervicitis, 124 in endometrial epithelium, 240 metastatic cancer of, 290, 328 Bacterial endocarditis, amnion infections by, 659 in malignant cells, 183 Apocrine glands Bacteroides Anaphase lag, mosaicism from, 424, 427, 433, 436 disorders of, 25, 28, 29 in puerperal endometritis, 250 Anatomy of vulva, 14, 15 in salpingitis etiology, 347 of cervix, 102-123 Appendicitis, oophoritis and, 387 Balanitis xerotica obliterans, 40 of fallopian tube, 341-342 Appendix Barr bodies of ovary, 365-386 endometriosis of, 416 formation of, 443 of vagina, 59-63 mucoceles of, 471 possible presence in dysgerminomas, 5 29 of vulva, 13-16 pinworm infections of, ovarian spread of, 391 as sex chromatin, 427, 428 Androblastomas, see Sertoli-Leydig cell tumors Appendix testis, 7 Bartholin cyst, histopathology of, 26-27 receptors, lack of, in testicular Appetite loss, from endometriosis, 406 Bartholin glands, 13, 14, 15 feminization syndrome, 445-446 Arborization, of cervical mucus, 109 adenocarcinoma of, 46, 51 , 10, 206, 207 Arcuate artery, 673 Basal artery, 213, 214 cytological effects of, 767 Argentaffin cells in placenta, 674 in experimental animal tumor studies, 803, 810 in mucinous ovarian tumors, 192, 469, 568, changes in pregnancy, 684 chronic exposure effects, 804 611 lesions in, 688 from gonadoblastomas, 57 4 in ovarian carcinoid, 566 Basal cell carcinoma from granulosa cell tumors, 611 Arginosuccinic aciduria, prenatal diagnosis of, 714 of cervix, 146, 147, 157-158, 180 from Krukenberg tumors, 63 7 Argininosuccinic acid synthetase, in prenatal in mixed tumors, 560, 561, 606 from Leydig (hilus) cell tumor, 615 diagnosis, 714 of vulva, 50-51 in menstrual cycle, 208 Arias-Stella reaction, 89, 91 Basal cell hyperplasia ovarian biosynthesis of, 372 in clear-cell endometrial carcinoma, 294, 296, of cervix, in pregnancy, 121 in polycystic ovarian syndrome, 402 483 from oral contraceptives, 133 in postmenopausal women, 279 in ectopic pregnancy, 195, 654, 696 Basal cell nevus syndrome, ovarian fibromas in, from Sertoli-Leydig cell tumor, 616 in gestational endocervix, 140 515, 588 Androstanedione, 207 Armadillo, choriocarcinoma in, 826, 827 Basal cells Androstenedione Arrhenoblastoma, see Sertoli-Leydig cell tumor cytology of, 745 estrone conversion of, in endometrial carcinoma Arrhenoma, see Sertoli-Leydig cell tumor in Trichomonas infections, 752 patients, 279 Arsenical insecticides, vulvar carcinoma after Basement membrane, in cervical carcinoma, 173- in menstrual cycle, 208 exposure to, 44 175 Sertoli-Leydig cell tumors and, 517 Arteries Basosquamous carcinoma, of vulva, 51 Anencephaly of ovary, 366 Battledore placenta, 655 in aborted fetuses, 692, 793 of placenta, 674-675 Beagles, genital tract tumors in, 824, 845-846

865 Index

Behcer's syndrome, symptoms of, 24-25 Body temperature C bands of chromosomes, 421 Benign neoplasms elevated, as indicator of ovulation, 739 C11 hydroxylase of cervix, 136-141 endometrial dating and, 221 deficiency of, female pseudohermaphroditism in, of vagina, 73-7 4 in Stein-I.evenrhal syndrome, 401 448 of vulva, 28-36 Bone, metastatic cancer of, 290, 536 prenatal diagnosis, 714 Benzopyrene, rumor induction by, in animals, 801, Bony tissue, in cystic teratomas, 601 C:!1 hydroxylase 813-814 Bouin's fixative, for cervical punch biopsies, 169, deficiency of, female pseudohermaphroditism in, Beta subunit, in rest for gestational trophoblast 170 448 disease, 704 Bowel prenatal diagnosis, 714 Bicarbonate, in oviductal fluid, 345 adhesions of, from endometriosis, 409 Calcification Bilharziasis, Jee Schistosomiasis endometriosis of, 416 ectopic, in tuberculous salpingitis, 351 Bilirubin, in erythroblastosis feralis diagnosis, 719 Bowen's disease, of vulva, 41, 44, 45-46 of leiomyomata, 301-304 Biopsies, 244 (See abo Conization biopsy, Punch Bowman's capsule, 4 Call-Exner bodies, 378, 507, 508 biopsy) Boxers, ovarian rumors in, 850 in animal tumors, 844, 851, 853 for cervical intraepirhelial neoplasia, 144-145 Brain, metastatic carcinoma of, 708, 709 carcinoid acini and, 563, 566 of cervix, 120 Brain damage, polycystic following, 402 material resembling, in gonadoblasromas, 571- of endometrium, 246-248 Branched-chain ketoacid decarboxylase, in prenatal 574 of vulva, 51-52 diagnosis, 717 in mixed rumor, 578 Birds, genital tract rumors in, 836-839 Branching enzyme, in prenatal diagnosis, 715 Calymmatobacterium granu/omatiJ, as cause of Birth. (See abo Labor) Breast granuloma inguinale, 17, 22 endometrial implantation during, 141 cancers of CAMP, in hormone receptor action, 241 endometritis following, 251 metastases, 51, 202, 297, 359 Cancer, Jee Carcinoma, Tumors epidermoid inclusion cysts following, 70 to ovary, 627, 631-634, 635 Candida sp. trauma, cervical cysts from, 134-135 ovarian steroid enzymes and, 369, 371, 3 7 5 vaginal infections from, 68 tubal ligation after, salpingitis following, 348 cystosarcoma phylloides of, 339 vulvar infections from, 23-24 Bizarre leiomyomata, 307, 308, 326 development of, in testicular feminization, 445, Candida albicam, cytological identification of, 752, Black women 446 754 cervical cancer in, 177 intraductal papillomas of, comparison to vulvar Candida vaginaliJ, cervical infections from, 124 leiomyomata in, 300 , 31 Carbohydrate metabolism, inborn errors of, in, 323 swelling and/or tenderness of prenatal diagnosis, 713-718 X-linked glucose-6-phosphare dehydrogenase in, from granulosa cell rumors, 507 Carbomerhylcellulose, vaginal lesions induced by, cervical neoplasia and, 15 7 as ovulation indicator, 739 813 Bladder with teratocarcinoma, 595 Carbonic anhydrase, in rubal epithelium, 345 cystic rupture into, 560 rumor induction in, in animals, 803, 807 Carbowax 1000, genital tract tumor induction by, metastatic cancer of, 75, 172, 179, 186, 289 Breast tissue, ectopic, in vulva, 31 in animals, 815 rumors of, 300 Brenner rumors Carcinoembryonic antigen (CEA), in detection of metastases, 202 of ovary, 454, 455, 485-494, 606 cancer recurrence, 187 BlaJtomyceJ, endometrial infection by, 256 in animals, 810, 845 Carcinogens, animal tumor induction by, 800-801, Bleeding. (See abo Hemorrhage, Uterine bleeding, carcinoids and, 566, 632 810-816 Vaginal bleeding) Broad , 6, 8 Carcinoid syndrome, 564-565 abdominal, from salpingitis isthmica nodosa, adrenal rests in, 358 medullary thyroid carcinoma in, 567 353 benign cysts in, 346 Carcinoids from endocervical polyps, 129 endometriosis of, 405, 407 metastasis of, 631-632 Blesbok, genital tract rumors in, 827 hemangiopericyromas of, 310 in mixed tumors, 560, 566-568, 606 Blood ovary attachment to, 365 of ovary, 507-508, 564-566 carcinonoma spread to ovary by, 635-637 parasitic leiomyomata in, 300 Carcinoleiomyosarcoma, spontaneous ovarian, in cervical cancer metastases by, 186 rumors of, 358 animals, 825 Blood vessels Buccal mucosal cells, use in sex chromatin Carcinoma. (See a!Jo under individual organs) of cervix, 103 analysis, 427-428 in animals of endometrium, 213-214 Buftalo, genital tract tumors in, 834 induced, 813 of ovary, 366-368 Bulbocarvernosus muscle, 61 spontaneous, 805, 809, 825-830, 833, 835, of uteroplacental system, 643, 673, 684, 685, Bulldogs, ovarian rumors in, 850 838, 840-842, 846, 848-849, 853, 856 786 Burkitt's lymphoma, in children and adolescents, of Bartholin gland, 27 stain for, 795-796 617, 618 basal cell, of vulva, 50-51 of vagina, 61 Buschke-Lowensrein giant condylomata, 18, 188 of cervix, 51, 129, 131, 171-197 of vulva, 15 Busulfan, cytological effects of, 763 invasive, 162, 171-197 Bochdalek's foramen, fluid in, in Meigs' syndrome, "Butterballs," in cystic teratomas, 601 polyps, 132 515 N-Buryl-N-nitrosurea, placental rumor induction endometrioid, 414-415 Body stalk, development of, 639 by, in animals, 812 in endometrial polyps, 259

866 Index

endometriosis and, 141, 414-415 805, 825, 843-845 atresia of, 11 of endometrium, 244, 267, 278-298 Cattle, freemartins in, 5 of, 114 cytologic detection, 763-765 Caudal , genetic defect of, 449 atypia of repair of, 125, 155, 157 hemangiopericytoma of, 310 Cauterization, postmenstrual, endometrial benign lesions of, 124-142 in situ, see Carcinoma in situ implantation in, 141 benign neoplasms of, 136-141 invasive, hyperkeratosis or parakeratosis in, 125 Cellular inclusions, amniocentesis detection of, 714 biopsy of, 120 from keratinous cysts, 27 Cellular leiomyomata, 307, 308, 326 tissue processing, 774 mesonephric, 122 Celomic epithelium, 2-4 blood supply of, 103, 107 metastatic, tubal pinworm infections of ovary, 588 carcinomas of, 92, 127, 171-205, 296 resembling, 352 tumors of, 453-504, 588, 606-611 animal studies, 814 Paget's disease and, 46 Celomic , endometriosis from, 475 diagnosis, 173, 178, 201 polypoid, 132 Ceramides and ceramide enzymes, in prenatal FIGO staging, 171, 172, 179, 186 with sarcoma, see Mullerian tumors diagnosis, 714, 716 histology, 173-175, 244 simplex, of vulva, 43 Cerebrospinal fluid, in cystic teratoma cysts, 601 HSV-2 and, 128 of , 51, 52 , anatomy of, 102-103 in situ, 43-44, 143-164 of vagina, 74-79 Cervical intraepithelial neoplasia (CIN), 143-164 cytology, 756-759 of vulva, 46-49 biopsies of, 144, 176 intraepithelial, 175 verrucous, cervical schistosomiasis and, 129 carcinoma in situ and, 143-164 invasive, 160, 177-187, 244 Carcinoma in situ (CIS) cellular dyskariosis in, 755-756 metastases, 51, 175, 177-179, 186, 189, 297, in animals, 826 cytological identification of, 755-759 627, 632 biopsies for, 52 definitions and terminology in, 143-149, 755 in pregnancy, 187-188 of cervix, 43, 44, 172 distribution of, 158-160, 177 prognosis, 186-187 cervical intraepithelial neoplasia and, 143-164 endocervical "gland" and, 158, 173-174 radiotherapy, 198-199, 761 cytology, 154-155, 756 epidemiology of, 149-150 rarity, in animals, 809, 823, 856 progression to invasive carcinoma, 173 etiology of, 150-152 squamous, 47, 177-187, 198, 278, 359 cytology of, 757-759 management of, 160-162 treatment, 175-176, 186, 198-199, 761 definition of, 143-144 microinvasive cervical carcinoma from, 174-175 choriocarcinoma of, 201 after DES exposure, 99 microscopic morphology of, 152-155 clear cell adenocarcinoma of, 296 development of, 172, 173, 178 mild , 755-756 after DES exposure, 189 of endometrium, 265, 272 moderate dysplasia, 756 colposcopy of lesions of, 155, 156, 158, 160- epidemiology of, 150 origin of, 155-158 162, 166-168 fiber cells in, 758 progression to invasive carcinoma, 173 columnar epithelium of, 108-112 keratinizing, 756 severe dysplasia/carcinoma in situ, 757-759 cysts of, 129-130, 134-135 stains for, 168 stains for, 168 cytology of, 169, 745 of vagina, 78 as venereal disease, 150 definition of, 798 of vulva, 41-44, 52 Cervical nerves, 103 development of, 211-213 vulvar dystrophies and, 40, 41 Cervical smear, technique of, 770 diagnosis of lesions of, 166-170 Carcinosarcomas Cervicitis, 249 dysplasia of, 99, 144, 162-163 in animals, 811 acute, 124 cytology, 755-756 of cervix, 197, 201 cytology, 750 after DES exposure, 99 of fallopian tube, 361 chronic, 125, 736 treatment, 160 of ovary, 454, 494-495 cryosurgery of, 762 ectopic pregnancy in, 648 of uter:'s, 323, 331, 336-338 gonorrheal, 251 endometriosis of, 140-141, 404-405 Cardiovascular disease, cervicovaginitis infertility and, 736 erosion of, after prenatal DES exposure, 93, emphysematosa with, 130 trichomonad, cytology of, 75 2 95-97 Cardlike scleroderma, of vulva, 36 tuberculous, 128-129 fibroadenoma of, 140 Carotin, in cells, 380 Cervicovaginitis emphysematosa, histopathology gliomas of, 135 Cartilage of, 129-130 granulomatous infections of, 128-129 in cervical mucosa, 122 Cervix. (See also Endocervix, Exocervix) hemangiomas of, 13 7-138 in ovarian mixed tumors, 496, 497 adenocarcinoma of, 122, 125, 126, 179, 180, herpesvirus infection of, 126-128, 131 in teratomas, 604-606 189-196 histology of, 102-123 Cartilagenous differentiation, in mixed Mullerian in animals, 809 hyperkeratosis of, 125, 127 tumors, 337 cytologic diagnosis, 760-761 incompetencies of Caruncles, urethral, 51-52 irradiation, 199 abortion and, 692 Cavernous nerves, 16 metastatic, 291 respiratory distress syndrome and, 720 Castrate animal, experimental tumor studies on, types, 190 infertility from abnormalities of, 736-737 803, 805 of, 140 inflammations of, 110-112, 124-131 Catalase, in prenatal diagnosis, 714 anatomy of, 102 intraepi thelia! neoplasia of, see Cervical Cat, spontaneous genital tract tumors in, 800, animal models for tumors of, 812-816 intraepithelial neoplasia

867 Index

Cervix [cont.] in animals, 809, 812-816 teratoblastomas in, 592-593 invasive carcinomas of, 160, 177-187 benign, 131-140 teratocarcinomas in, 595-597 histologic classification, 180 diagnosis, 166-170 teratomas in, 552-553, 554, 558, 597-600 irradiation of, morphology following, 197-200 gross examination, 774-778 thecomas in, 613-614 leiomyomas of, 131-137, 140 malignant, 171-205 vaginal gonorrhea in, 63 infertility and, 737 venereal infections of, 129 vaginal smear cytology of, 768, 770 ligaments supporting, 103 verrucous carcinoma of, 138, 139, 179, 180, Chimeras, from double fertilization, 431 lymphatics of, 103 188-189 Chimpanzees, spontaneous genital tract tumors in, lymphomas of, 201-202 vestigial and heterotopic structures of, 121-122 825, 826 malignant melanoma of, 200-201 Cesarean section Chlamydia, as cause of lymphogranuloma malignant tumors of, 110, 119, 122, 171-205, hysterectomy with, in cervical cancer, 188 venereum, 17, 22 244 indications for, in maternal genital herpes Chlorambucil, in therapy of dysgerminomas, 53 7 cytology, 745, 755 infection, 75 3 "Chocolate cyst," endometrioma of, 477 metastases, 83 leiomyomata cause of, 300 Cholesterol, as steroid precursor, 207 tissue processing of, 778 cGMP, in hormone receptor action, 241 Cholesterol esters, in prenatal diagnosis, 718 mesonephric papillomas of, 140 Chalone, of cervical epithelium, in neoplasia, 160 Chondrosarcomas metastatic disease of, 202, 290 Chamois goat, ovarian tumors in, 837 in animals, 835 microglandular endocervical hyperplasia of, Chancre, syphilitic, of vulva, 17, 19-21 of cervix, 201 133-134, 192 Chancroid in children and adolescents, 616 morphology of, 104-112 of cervix, 129 of fallopian tube, 361 Nabothian cysts of, 94, 108, 114, 115, 776 of vulva, 17, 23 in mixed mesodermal tumors, 554, 560 nerves of, 103, 110 Charcot-Leyden crystals, in tubal pinworm of ovary, 497 occult invasive carcinoma of, 176-177 infections, 3 52 of uterus, 323, 335 papillary adenofibroma of, 139-140 Chediak-Higashi syndrome, prenatal detection of, Chorangioma papillomas of, 138-139 714 fetal anomalies with, 668 physiology of, 104-112 Chemotherapy symptoms and etiology of, 668, 669 polyps of, 131-132, 134, 135 of cervical carcinoma, 186 Chorioadenoma destruens, see Invasive mole infertility and, 737 of choriocarcinoma, 700, 705, 709 Chorioamnitis, causes and effects of, 659, 660 "postirradiation dysplasia" of, 199-200 of dysgerminomas, 53 7 Choriocarcinoma( s), 698-699 precancerous conditions of, drug-induced of endodermal sinus tumors, 545, 594 in animals changes mimicking, 763 of granulosa cell tumors, 511 induced, 812 in pregnancy and puerperium, 120-122 for mixed MUllerian tumors, 339 rarity, 823, 856 prenatal exposure to diethylstilbestrol effects on, of polyembryomas, 548 spontaneous, 824, 826, 827 87-101 of teratomas, 554 of cervix, 201 prosoplasia of, 115-121, 131, 168 of tubal choriocarcinoma, 362 in children and adolescents, 550, 589, 594-595 pseudotumors of, 131-135 of uterine malignant lymphoma, 340 endometriosis and, 141 retroversion of, infertility and, 737 Cherry hemangioma, on vulva, 28-29 of faJlopian tube, 362 ridges of, from DES exposure, 93, 98 Chiari-Frommel syndrome, vaginal smear cytology as hydatidiform mole as precursor of, 705, 708 sarcoidosis of, 391 of, 770 hyperreactio luteinalis in, 702 sarcomas of, 131, 134, 137, 139, 140, 182, Children. (See also Infants) metastasis of, 202, 707-708 201-202, 323 cervical mesonephric papiJJomas in, 140 molar pregnancy and, 700, 704 gross examination, 778 choriocarcinoma in, 550, 594-595 ovarian metastasis of, 632, 635 squamous carcinoma of, 47, 177-187, 198, 278, dysgerminomas in, 529, 589-592 of ovary, 528, 533, 546, 550-552 359 embryonal carcinomas in, 592-593 gestational, 595 cytological diagnosis, 759-761 endodermal sinus tumors in, 539, 594 in mixed tumors, 537, 547, 551, 554, 568, squamous epirhelium of, 104-107, 199 epithelia! neoplasms in, 606-611 573, 574, 599 squamous metaplasia of, cytology, 749-750 germ cell-sex cord stromal tumors in, 579 in placenta, 709, 786 stains for lesions of, 168 granulosa cell tumors in, 511, 611-612 in pregnancy, 705 stenosis of, infertility and, 736 Leydig (hilus) ceJI tumors in, 615 theca lutein cysts with, 397 stump of, carcinoma of, 187 malignant lymphomas in, 616-619 of vagina, 84, 85 subcolumnar reserve cell carcinoma of, 196-197 mixed germ ceJI-sex cord stromal tumors of, vulvar metastases of, 51 synechiae of, infertility and, 737 576 Chorioepitheliomatous-like lesions, in hamsters, tissue examination of, 169-170 ovarian cysts in, 618-621 835 trachoma inclusion conjunctivitis of, 755 ovarian tumors in, 586-626 Choriomas, in animals, 827 transformation zone of, 112-120 sarcomas in, 616-617 Chorion frondosum, 641, 642 atrophic, 15 5 sclerosing stromal tumors in, 614, 615 Chorionepithelioma, see Choriocarcinoma histogenesis diagram, 120 Sertoli ceJI tumors in, 613 Chorionic gonadotropins role in neoplasia, 158-160, 163 Sertoli-Leydig ceJI tumor in, 615-616 from choriocarcinomas, 55 0 tumors of sex cord-stromal tumors in, 611-616 use in detection, 708, 709

868 Index

Chorionic gonadotropins Cloacal folds, 9 of cervical tissue, 170 elevated, Clomiphene of uterus, tissue processing of, 774-77S from dysgerminomas, S33, S37 antiestrogen effect of, 737 Congenital malformations with ovarian neoplasms, S89, S92, 595 in polycystic ovary therapy, 740 of female genital tract, 1-12 in pol yembryomas, S49 Clostridia, in peritonitis from abortion, 69S prenatal diagnosis of, 713 secretion by, syncytiotrophoblast, 639 Clostridium perfringem, in puerperal endometritis, sex chromosome role in, 4 theca lutein cysts from, 398 2SO Conization, for cervical neoplasia, 160, 168, 171, trophoblast monitoring by, 704 Clubbed feet, amnionic bands and, 6S6 172, 17S in tumor induction studies, 812 "Clue cell" Connective tissue, of vulva, tumors of, 28-31 Chorionic growth hormones, secretion by, in cervico-vaginal smears, 752 Constriction rings, from amnionic bands, 656 syncytiotrophoblast, 639 of Haemophilus vagina/is infection, 68 Contraceptive devices. (See also Intrauterine Chromosome abnormalities, 4, 421-427, 436-438, Coccoid bacteria, in cervico-vaginal smears, 7S 1 contraceptive devices) S7S Cocker spaniel, ovarian tumor in, 8S2, 8S3 cervical neoplasia and, 1 SO in aborted fetuses, 793 "Coffee-bean" appearance, of benign Brenner Contraceptives, intravaginal, cervical lesions from, detection by amniocentesis, 6S6, 713 tumors, 489, 490, 566 813 in ectopic fetuses, 649 Coiled arteries, of ovary, 366, 367, 383 Coombs' test, of autoimmune hemolytic anemia, spontaneous abortion from, 691-69S Collagen S60 human in fibromas, S13, S1S Copper, teratomas from, SS 2 in metaphase, 422 in ovarian stromal cells, 3 74 Coproporphyrin, in prenatal diagnosis, 714 number of, 421 in sclerosing stromal tumors, 614 Corona radiata, 377, 378 studies on, in aborted fetuses, 790-791 Collie, ovarian tumor in, 853 Corpora albicantia, 368, 372, 378, 380, 382, 384 Cilia Collision tumors, of cervix, 197 cysts of, 396, 397, 621 in adenomatous hyperplasia, 271 Colon in polycystic ovary, 399 in endometrial cells, 234, 23 5 carcinoma of Corpora fibrosa, 372, 378, 380, 384 Ciliated cells endometriosis and, 417 , 381, 779 in ovarian neoplasms, 4S6, 457, 464-467 metastases, 297, 631 Corpus luteum, 368, 371, 389, 779 of tubal epithelium, 343, 34S, 346 mucinous adenocarcinoma of, 474 abnormal persistence of, 24S-246 function in ovulation, 344 Colpocervicitis cystica, see Emphysematous blood supply of, 366 in hydrosalpinx, 3SO vaginitis cysts of Circumcision, cervical neoplasia and, 1SO Colpocervicitis emphysematosa, see Emphysematous in children and adolescents, 620-621 Circumvallate placenta, 664 vaginitis dysfunctional uterine bleeding from, 262 Circummarginate placenta, 664 Col pomicroscopy inadequate function of, 246 Citric acid cycle, in endometrial epithelium, 240 of carcinoma in situ, 178 infertility from, 739 Citrullinemia, prenatal diagnosis of, 714 of cervical inttaepithelial neoplasia, 146, 1S2, involution of, 380, 381 Clear cell adenocarcinoma 158-160 maturation and regression of, 209, 378, of cervix, 189, 190, 192, 194-196 Colposcopy 380-381 of endometrium, 285-286, 294-296 of cervical invasive carcinoma, 173, 178, 187 in oophoritis, 387 as Mullerian anlage, 296 of cervical lesions, 1SS, 1S6, 1S8, 160-162, in pregnancy, 382-383 from prenatal exposure to diethylstilbestrol, 166-168 structure of, 3 78, 380-381 87-101 of cervical transformation zone, 114 Cortical adenoma, in fallopian tube, 3S8 cytology, 766-767 of cervicitis, 12S Cortical cords, 4, S Clear cell carcinoma, of ovary, 296, 454, 468 Columnar cell carcinoma, of cervix, 190-192 Corticoids, 206 Clear cell hidradenomas, of vulva, 33 Columnar cells, in ovarian neoplasms, 4S6, 4S7, Corticomedullary antagonism theory, of sex Clear cell leiomyomata, histology of, 306-307 464, 46S, 467, 468, 483, 497 differentiation, 5 Clear cells Columnar epithelium Corynebacterium diphtheriae, in cervical and vaginal in cervical squamous cell carcinomas, 181 of cervix, 108-112 diphtheria, 129 in endometrial carcinomas, 281 in repair , 12 S Corynebacterium minutissimum, as cause of genital in ovarian neoplasms, 4S6, 464, 467, 468 cytologic atypias of, 748, 749 erythrasma, 24 Cleft palate, in aborted fetuses, 793, 794 Computers, use in cytohormonal studies, 767 Corynebacterium vagina/is, see Hemophilus vagina/is Clinical staging. (See also Fl GO staging) Condyloma lata, histopathology of, 17, 19, 20 Cotyledons, of placenta, 642, 786 of vulvar melanoma, 49-SO Condylomata acuminata, 131 Couvelaire uterus, from abruptio placentae, 667 of vulvar squamous carcinoma, 47 cervical carcinoma and, 185 Cows, genital tract cancer in, 80S, 809, 823, 828- , 10, 13 of cervix, 138, 188, 189 830, 840-843 absence of, 16 cytological identification of, 7SS Coxsackie B virus, in salpingitis etiology, 347 anatomy of, 14-1S histopathology of, 16-18, 48-49 Coypu, genital tract tumors in, 827 developmental defects of, 16 Cone biopsies Cramping pain, from endometriosis, 406 enlargement of, from Sertoli-Leydig cell tumors, of cervical cancer, 187 Creatine phosphokinase, as fetal death indicator, S17, 523, 616 for cervical intraepithelial neoplasia, 144-14S, 712-713 leimyomas of, 30 160, 162 Creatinine, in diagnosis of fetal maturity, 719-720

869 Index

Cresyl violet, for membrane-infection detection, 659 mesonephric, 28, 121 Darier's disease, of vulva, 25-26 Cribriform pattern, in endometrial carcinoma in ovarian, 369, 371, 393-403, 779 DDT, tumors in hares and, 83 7 situ, 272, 275 in animals, 804, 839 Decidual polyps, of cervix, 131-133 Crohn's disease in children and adolescents, 618-621 Deer, genital tract tumors in, 827 granulomatous salpingitis in, 352 ectopic pregnancy and, 648 Dehydroepiandrosterone of vulva, 25 parovarian, 354, 393, 648, 779 in menstrual cycle, 208 Crowded cell index, for cytohormonal evaluation, serous inclusion type, 393, 394 ovarian synthesis of, 3 72 767 of vagina, 70, 72 Delalurin Cryocauterization, of cervical neoplasias, 161-162 of vulva, 26-28 pseudosarcomatous pattern from, 263 Cryosurgery, cytological changes produced by, 762 stromal decidual response to, 413 Cryptococcus, endometrial infection by, 256 of ovary, 281, 454, 456, 458, 459, 461-463, 471 Delivery, see Birth Cryptorchidism, in hermaphrodites, 430 in animals, 824, 835, 838, 841 Demons-Meig's syndrome Cubitus valgus, in Turner's syndrome, 434-435 mucinous, 473-475, 779 from granulosa cell tumors, 612 Cuboidal cells serous, 478, 479, 499, 766, 779, 780 from thecomas, 613 of ovarian epithelium, 368, 371, 375 Cystadenomas 11-Deoxycorticosterone hypersecretion of, in cysts, 393 in animals virilization from, 448 in ovarian neoplasms, 456, 464, 465, 467, 468, induced, 801, 808 Dermatan sulfate, in prenatal diagnosis, 716-718 482, 497 spontaneous, 805, 807, 833, 837, 839-840, Dermatofibromas, see Histiocytomas Culdoscopy 847-849 Dermatofibrosarcoma protuberans, 51 for endometriosis diagnosis, 409 of ovary, 454 Dermatomyositis, with ovarian neoplasms, 587 in infertility studies, 401, 738 mucinous, 469-473, 607, 611-613 Dermatophytes, vulvar infections from, 23-24 Cumulus cells, ovum coating by, 344 serous, 455-461, 489, 607-610 Dermoid cysts, 604 , 378 Cystadenofibroma in animals, 834, 843 Curettage, 244 of ovary, 454, 455, 463-467 of ovary, 528, 552, 560-562 for abnormal endometrial maturation, 260-262 in children and adolescents, 607-610 Dermoid mamilla, 558 abortion using, 695, 696 Cystathionine and cystathionine enzymes, in Dermoid nipple, 558, 601 of adenomyosis, 312-314 prenatal diagnosis, 716, 717 Dermoid protuberance, 557-558 Asherman's syndrome from, 256 Cystathioninuria, prenatal detection of, 714 DES, see Diethylstilbestrol endocervical, for lesion diagnosis, 160-162, Cystic degeneration, in leiomyomata, 302, 304 Desmosomal-tonofilament complexes, separation 169-170 Cystic fibrosis, prenatal diagnosis of, 714 of, in cervical carcinoma, 184, 185 in endometrial carcinoma, 279 Cystic glandular hyperplasia, 265 Desmosomes of endometrial hyperplasia, 266-267 Cystic teratomas, 469, 489, 528, 555-560 in adenosquamous endometrial carcinoma, 293 indications for, 245 in animals, 834 decrease of, in cervical intraepithelial neoplasia, of invasive mole, 704-705 in children and adolescents, 599-606 148, 163 of leiomyomata, 300 Cystic tumors, in animals, 828 Diabetes mellitus for mixed MUllerian tumor diagnosis, 330 Cystinosis, prenatal diagnosis of, 714 abortion from, 694 perforation from, 280 Cystosarcoma phylloides of breast, MUllerian in animals, in, 810 for tuberculous endometritis, 256 adenosarcoma similarity to, 339 with clear-cell endometrial carcinoma, 294 Cushing's syndrome Cytochrome oxidase, in endometrial epitheli urn, 240 condylomata acuminata in, 18 from ovarian neoplasms, 587 Cytogenetic studies with endometrial carcinoma, 278, 279 polycystic ovaries in, 402 on aborted fetal tissue, 790-793 erythrasma with, 24 with Sertoli-Leydig cell tumors, 616 of cervical dysplasia cells, 14 5 fetal respiratory distress syndrome in, 720, 721 Cyclic nucleotides, in hormone-receptor Cytology large placenta in, 642, 786 interaction, 241 of cervical lesions, 146, 166, 169 placental infarcts and, 666-667 Cyclophosphamides of female genital tract, 744-771 with Turner's syndrome, 436 in therapy of Cytomegalic viral inclusion disease vulvar squamous carcinoma with, 47 dysgerminomas, 53 7 abortion and, 692 Diaphragm, cervical neoplasia and use of, 150 endodermal sinus tumors, 545 cytological identification of, 755 Dienestrol, prenatal exposure to, genital changes Cylindroma, of cervix, 190, 196-197 Cytopipette, 168, 169 from, 87 Cyst(s) Cytosol receptors, for steroid hormones, 241 Diethylnitrosamine (DEN), ovarian tumor in cervicovaginitis emphysematosa, 129-130 Cytospray fixative, 168 induction by, in animals, 801 of corpus luteum, 262, 381, 396 Cytotrophoblast( s) Diethylstilbestrol (DES) dysfunctional uterine bleeding from, 262 in choriocarcinomas, 551, 553, 705, 707 animal tumor induction by, 801, 810, 813, 854 in dysgerminomas, 530 formation of, 639, 643 ovarian neoplasms from, 588 in emphysematous vaginitis, 69, 70 histology of, 694 vaginal and cervical abnormalities from prenatal endometrial, 267, 409 placental vascular supply and, 676 exposure to, 87-101, 813 of endometrial glands, 254 clear cell adenocarcinoma, 88-93, 192, 194, epithelial inclusion type, of cervix, 134-135 195, 766-767 in fallopian tube, from fetal tissue, 345-348 Dachshund, spontaneous cervical tumor in, 824 endocervical eversion, 113 lutein, 702 Danazol, in endometriosis therapy, 7 41 nonneoplastic, 93-98

870 Index

preneoplastic, 98-99 in gonadal dysgenesis, 53 7 interstitial, 653 Difluorobenzene, in immunocompetence testing, gonadoblastoma with, 528, 529, 530, 534, 538, in isthmus, 653 186-187 573, 574 molar, 362 Digital amputations, amnionic bands and, 656, histiogenesis of, 528-529 in ovary, 648, 653-655 785 incidence of, 5 29 pathology of, 650-653 Dihydrotestosterone, decrease of, in male macroscopic appearance of, 529-530, 589 recurrent, 649-6 50 pseudohermaphrodite, 446 metastasis of, 534, 536 after salpingitis, 353, 648, 738 Dilatation and curettage. (See also Curettage) microscopic appearance of, 530-536, 589-591 transport delay and, 735 of uterus, 247 mixed tumors of, 529, 530, 533, 537, 545, 546, tubal choriocarcinoma with, 362 Dimethylbenzanthracene (DMBA) 554, 567, 568 after tubal reanastomosis, 356 ovarian tumors from, 588 prognosis of, 536 after tubal surgery, 739 tumor induction in animals by, 800-803, 806, rupture of, 5 34 after tubercular salpingitis, 351, 352 807, 811, 814-815 survival from, 591-592 Ectopic sites, of endometrium, 404 hormone effects on, 804-805 synonyms of, 5 28 Ectopy, see Endocervical eversion Dimethylnitrosourea, genital tract tumor testicular seminoma similarity to, 527, 528, 530, Ectropion, see Cervical erosion; Endocervical induction by in animals, 815 534 eversion Diphtheritic cervicitis, 129 therapy of, 591-592 Edema Diplococci, cervical infections from, 124 in 45X mosaicism, 438 of external genitalia, in lymphogranuloma Disjunction Dyskariosis, of cervical cells, in mild dysplasia, venereum, 23 in chromosome separation, 424 755-756 massive, of ovary, 621-623 errors of, 424-426 Dyskeratosis, in cervical carcinomas, 181, 182 in toxemia of pregnancy, 668 Distension, abdominal, from endometriosis, 406 Dysmenorrhea Efferent ducts, 3, 4, 5, 7 Diverticula, in salpingitis isthmica nodosa, 353 in adenomyosis, 312-313 Elastic tissue Diverticulitis, oophoritis and, 387 from leiomyomata, 300 in spiral arterioles, 214 DNA ligamenta! denervation for, 103 in uterine arteries of pregnancy, 683 in cancer immunotherapy, 186 Dysontogenetic tumor, 331 Electrocauterization, for cervical neoplasia, 160, changes in, in upostirradiation dysplasia," 200 Dyspareunia, from endometriosis, 40 161 in dysgerminomas, 529, 532 Dysplasia Electron microscopy, of cervical neoplasias, 145, estradiol effects on, 209 of cervix, 144 149, 159 estrogen activation of, 241 cytology, 755-756 Elephant, genital tract tumors in, 827 of herpesviruses, 126-12 7 after DES exposure, 99 Embolism, from amniotic fluid, 662 increased synthesis of, in damaged epithelium, of vagina, 76-78 Embryoid body 125 after DES exposure, 99 in embryonal carcinomas, 592, 593, 601 DNA microspectrophotometry, of cervical Dysmenorrhea, from ovarian tumors, 587 in polyembryomas, 548, 549 dysplasia cells, 145 Dystocia , of female genital tract, 1-12 DNA "repair enzyme," in prenatal diagnosis, 718 from cystic teratoma, 557, 559 Embryomas, in animals, 835 Doderlein bacilli, cytolysis of intermediate cells from leiomyomata, 300 Embryonal carcinoma, 528, 545. (See also by, 749, 769 Dystrophic conditions, of vulva, 36-3 7 Endodermal sin us tumor) Dog, genital tract tumors in, 800, 805, 824-825, canine ovarian carcinoma and, 856 845-856 in children and adolescents, 589, 592-594 Domesticated animals, spontaneous genital tract EASC cells in mixed tumors, 534, 546, 554, 568, 573, 574, rumors in, 823-825, 839-856 of ovary, 3 72, 454 576, 599 Donovan bodies, of granuloma inguinale, 17, 22, in rumors, 499-501 in ovary, 544, 546-548 23 Eccrine sweat glands, 14 Embryonal rhabdomyosarcoma, 339 Double primary carcinomas, of cervix, 180 adenomas of, 3 3 Embryonic node, 558 Down's syndrome, detection by amniocentesis, 656 Echinoccosis, of cervix, 129 Emphysema vaginae, see Emphysematous vaginitis DPNH, see NADH ECHO virus, in salpingitis etiology, 347 Emphysematous vaginitis, histopathology of, 69, Drosophila melanogaster, ovarian lesions in, 839 Ectopic decidua, of corpus luteum in pregnancy, 70 Duck, ovarian tumors in, 845 382-383 Encephalitis, in newborn, from genital herpes, 753 Duct system, in , 5-9 Ectopic ovarian tissue, 365-366 Endocervical curette, 161 Duval sinuses, 542 Ectopic pregnancy, 64 7-655 Endocervical eversion, histopathology of, 112-122 Dysgenetic tumors, in 45 X mosaicism, 438 Arias-Stella reaction in, 195 Endocervical glands, 108 Dysgerminomas, 528-538, 545, 569 choriocarcinoma with, 550 in cervical carcinoma, 185 in animals, 805, 837, 838, 844, 845, 851-852, as choriocarcinoma precursor, 708 Endocervical mucinous cystadenomas, of ovary, 856 complications of, 653 470-471 behavior of, 534, 536 congenital anomalies in, 649 Endocervicitis, 110 in children and adolescents, 589-606 endometrium in, 655 papillary, 111 clinical aspects of, 529, 589 etiology of, 648-650 Endocervix endocrine aspects of, 53 7 in fallopian tube, 647-653, 779 adenocarcinoma of, 191, 192, 279, 291 genetic aspects of, 537-538 induced abortion and, 695-696 columnar epithelium of, 108

871 Index

Endocervix [cont.} of ovary, 404, 409-413, 475, 493, 779 ovarian carcinoma with, 481, 482 curettings of, tissue processing, 77 4 infertility from, 740-7 41 precursors of, 267, 507 cytology of, 745-747 pathogenesis of, 405 Stein-Leventhal syndrome and, 276, 401 in arypias, 749, 750 theories, 47 5 cell physiology of, 238-242 epithelium of, arypia of repair of, 125, 126 pinworm infections and, 391 clear cell adenocarcinoma of, 195 "glands" of, in cervical carcinoma, 17 3-17 4 pelvic, 404-419 curettings of, processing, 773 ovarian epithelial metaplasia to cells resembling, upresumptive," 413 cytology of, 746, 747 370 symptoms of, 406, 409 in arypias, 749 stromal sarcoma of, 201 Endometritis, 249-257 cystic change in, 267, 268 Endocrinopathies, hormonal cytology of, 769-770 acute, 249-251 in animals, 809 Endodermal sinus tumors, (ovarian), 528 chronic, 252-257 dating of, 221 behavior of, 544 etiology of, 250-252 body temperatures and, 221 in children and adolescents, 592 gonorrheal, 251 in ectopic pregnancy, 655 clear cell carcinomas as, 482 hemorrhagic, 251 ectopic sites of, 404 clinical aspects of, 539 ichthyosis in, 254 enzyme activities in, 238-240 differential diagnosis of, 544 infertiliry from, 737 fine structure of, 226-234 extraovarian occurrences of, 538 placenta accreta from, 647 functional abnormalities of, 249 a-fetoprotein in sera of patients with, 539 placenta membranacea and, 664 glandular epithelium of, 226-232 incidence of, 5 38-5 39 postabortal, 250-252, 254 granulosa cell tumor effects on, 506-507 macroscopic appearances of, 539 postmenopausal, 225 histochemistry and biochemistry of, 238-240 microscopic appearance of, 5 39-543 puerperal, 250-253 Hodgkin's disease in, 297 mixed tumors of, 534, 535, 539, 545, 546, 551, senile, 254 hormone receptor sites in, 209-210 568, 573 tuberculous, 256, 737 hyperplasia of, 265-277, 281, 312, 313, 501 prognosis of, 545 tuberculous cervicitis and, 128 adenomyosis and, 315 synonyms of, 5 38-546 uterine bleeding from, 279 in animals, 809, 810, 826, 833, 846, 848, 853 therapy of, 545 Endometrium carcinoma and, 272 Endolymphatic stromal meiosis, 330 abnormal maturation of, 260-263 clinical aspects, 266 Endolymphatic stromal myosis, 309 actinomycosis of, 257 constitutional factors in, .265-266 of fallopian tube, 359 adenocanthoma of, 281, 290, 292, 477 histology, 266-267 of myometrium, 316 adenocarcinoma of, 270, 276, 276-292, 297, in polycystic ovaries, 401 of uterus, 328 477, 507 progestin therapy of, 263 Endometrial aspiration, technique of, 770 adenomyosis and, 315 uterine bleeding in, 279 Endrometrial cysts, 409, 417 diagnosis, 279 from ovarian cysts, 397 Endometrial glands, 212, 410, 411 epidemiology, 278-279 infertiliry from abnormalities of, 737 carcinoma in situ of, 272 gross appearance, 279-280 inflammatory diseases of, 249-257 cysts of, 254 incidence, 278 irregular shedding of, 244-246 in endometrial polyps, 258-259 metastasis, 202, 290 leiomyomata of, 251 in irregular shedding, 245-246 microscopy, 281-285 infertility and, 737 in menstrual cycle, 220 prognosis, 290 leukemia in, 297 in myometrium, in adenomyosis, 312-315 radiotherapy, 198-199 lymphosarcoma of, 297 in stromal sarcomas, 329 staging, 289-298 malignant tumors of, 249, 278-298 "Endometrial granulocytes," 221 treatment, 291-293 gross examination, 778 Endometrioid carcinoma ultrastructure, 285-286 in menopause, 220, 225 of cervix, 190, 192, 196 adenosquamous carcinoma of, 292-295 menstrual, 215 of ovary, 414-415, 477-482, 483, 485 in adults, 213 microscopy, 235, 238 Sertoli-Leydig cell tumor and, 522 arteries of, 213-214 in menstrual cycle, 209-211, 235 Endometrioid tumors, of ovary, 475-482 benign diseases of, 249-264 metastatic rurnors of, 297 Endometriomas biopsy of, 244 umixed," 246 of ovary, 410, 412, 454, 475-477, 740-741 indications for, 246-247 mixed Miillerian tumors of, 338 of vagina, 73, 84 techniques, 247-248 in neonate, 212 of vulva, 34 blood supply of, 213-214 maternal hormone effects on, 212, 213 Endometriosis, 404-419 carcinoma of, 247, 266, 278-298, 501 neuroglial tissue implantation in, 135 adenomyosis and, 315 adenomyosis and, 315 normal, 211-242 in animals, 825 in animals, 823-833, 856 oral contraceptive effect on, 262-263 of cervix, 140-141 cytological detection, 763-765, 770 ovarian epithelia! metaplasia to, 369, 370 diagnosis of, 409 estrinism and, 401 papillary adenofibroma of, 139 of fallopian tube, 354-355, 404 estrogens and, 272, 275-276, 574 polyps of, 246, 251, 257-262, 281, 501 ectopic pregnancy and, 648 in situ, 272 D and C for, 247 infertility from, 738 metastases, 51, 83-84 infertility from, 7 37 microscopy of, 409-413 to ovary, 627-629 malignancy in, 259-260, 280, 281

872 Index

uterine bleeding from, 279 Episiotomy, ectopic epithelium in, endometriomas early secretion of, 206 in postovulatory phase, 217-224, 230-232 from, 34 effect on in preovulatory phase, 226-230 Epithelial budding, in adenomatous hyperplasia, cervical epithelium, 104 in proliferative phase, 216-218, 226-229, 234 269, 270 cervical mucus, 736 microscopy, 234-235 Epithelial cells endocervical eversion, 113 scanning electron microscopy of, 234-238 cytology of, 744-746 endocervix, 108 schistosomiasis of, 25 7 benign atypias, 749 endometrial enzymes, 240, 241 secretory, 217-224, 230, 233 "Epithelia! cords," "testis cords" and, 856 endometri urn, 213 microscopy, 235-238 Epithelial inclusion cysts, of cervix, 134-135 leiomyomata, 300 secretory hyperplasia of, 245, 246 Epithelia! tumors vaginal mucosa, 61-62 sex steroid effects on, 214-224 of ovary, 453-504 endometrial carcinoma and, 272, 275-277, 279, squamous cell carcinomas of, 281 in children and adolescents, 606-611 291 squamous metaplasia of, 252-255, 281, 292 of vulva, 31, 33-34 in female embryo development, 10 stromal cells of, 220, 229, 232-234 Epithelioma Pflligerien, 575-579 from granulosa cell tumors, 506-507, 510, 511, stromal sarcoma of, 311, 328-331 Epithelium 611-612 synthetic progestin effects on, 263 of fallopian tube, 343 from hilus cell tumors, 521 tumors of squamous, see Squamous epithelium in menstrual cycle, 206-207, 208, 739 in animals, 809 of vagina, 64-67 in oral contraceptives, endometrial effects of, gross examination, 778 Epitheloid sarcomas, of vulva, 51 263 malignant, 259-260, 278-298 , 7, 8 from ovarian tumors, 266, 768 veins of, 214 Epulis tumor, of pregnancy, 29 prenatal therapy with, virilization from, 448 Endophytic carcinoma, of cervix, 179 Erythrasma, of genitocrural area, 24 secretion by Endosalpingiosis, 413, 737-738 Erythremia, with ovarian neoplasms, 587 ovarian cysts, 394 Endosalpinx, ovarian epithelium metaplasia to, Erythroblastosis fetalis paralutein cells, 380 369, 393 large placenta in, 642, 786 syncytiotrophoblast, 639 Endoscopy, of fallopian tube, 738 prenatal diagnosis of, 718, 719 from sclerosing stromal tumor, 514 Endothelioma, see Lymphangioma respiratory distress syndrome and, 720, 721 from Sertoli cell tumor, 517 English setter, ovarian tumor in, 849 symptoms and etiology of, 668, 669 synthesis of, 377 Enovid, tumor induction by, in animals, 813 Erythrocytes, in cervico-vaginal smear, 747 therapy with, endometrial carcinoma and, 275- Entamoeba histolytica Erythropoietic porphyria, prenatal diagnosis of, 277, 279 in cervico-vaginal smears, 755 714 trichomoniasis and, 68 vaginal infections from, 70 Escherichia coli in Turner's syndrome, 433 Enterobius vermicularis, 24 in animal adenocarcinoma, 826 "Estrogen carcinoma," 275-277 in cervico-vaginal smears, 755 in cervico-vaginal smears, 752 Estrogen therapy oophoritis from, 391 placental membrane infection by, 659, 669 of gonadoblastomas, 574 salpingitis from, 352 in puerperal endometritis, 250 tubal ciliated cell restoration by, 344 Enterococci in salpingitis etiology, 347 Estrone, 207 cervical inflammations by, 124, 125 vulvovaginitis from, 68 in menstrual cycle, 209 in oophoritis, 387 Esterase, in endometrial epithelium, 238 Estrone glucusiduronate, excretion of, in Entropion, 113 Estradiol endometrial carcinoma patients, 279 Enzymes in bovine ovarian tumor, 841 Ewing's grading, of endometrial adenocarcinomas, of endometrial epithelium, 238-240 effect on 281 in ovarian cells, 372 cervical epithelium, 104 Ewing's tumor, ovarian metastasis of, 632 Eosin stain, for cervical tissue, 170 endometrial enzymes, 241 Exanthemata, oophoritis with, 388 Eosinophilic index, for cytohormonal evaluation, in gonadal differentiation, 5 Exocervix, 59, 69, 102, 103 767 in experimental animal rumor studies, 805, 809 clear cell adenocarcinomas of, 88, 89 Ephelides, see Freckles in menstrual cycle, 207, 209 endometriosis of, 141 Epidermidization tubal receptors for, 344 hyperkeratosis and parakeratosis of, 125, 127 of cervical mucosa, 122 Estrinism leiomyomas of, 136 of endocervix, 115-116 polycystic ovaries with, 399, 401 multiparous, 103 Epidermoid carcinoma uterine bleeding with, 399 Exophytic carcinoma, of cervix, 179 in animals Estriol glucosiduronate, in endometrial carcinoma External genitalia induced, 809, 811, 813, 814 patients, 279 anatomy of, 13-16 spontaneous, 823 Estrogen(s), 207 embryology of, 9-10 of cervix, 51 in adenomyosis etiology, 315 External iliac vessels, 36 5 of vulva, 74-79 in animal tumor induction, 802, 803, 809, Extremities, endometriosis of, 404, 405 cytology, 767 812-813 Eye Epidermoid cysts chronic exposure effects, 804 experimental ovarian transplant to, 377, 798, of ovary, 568 cytological effects of, 767 802 of vagina, 70 desquamative inflammatory vaginitis and, 69 tumor transplantation to, 832

873 Index

Fabry's disease, prenatal diagnosis of, 714 salpingitis of, 249, 347-350, 779 biochemical disorders of, prenatal diagnosis, Fallopian tube, 6, 10 acute, 347-348 714-724 abnormalities of, in infertiliry, 734, 737-739 chronic, 348-349 circulation to actinomycosis of, 352 granulomatous, 350-353, 356 diagram, 643 adenocarcinoma of, 359-361 infertiliry from, 738 injection method of study, 794, 795 cytology, 765-766 salpingitis isthmica nodosa of, 353 cord strangulation of, 793, 794 staging and survival, 361 sarcoidosis of, 391 damage to, from herpesvirus, 128 of, 497 sarcomas of, 361 death in utero, amniocentesis studies of, 712 adenomyomas of, 307 schistosomiasis of, 351-352, 391 713 adhesions of, infertiliry from, 73 7 smooth muscle of, 342 glial transfer from, 135 adrenal rests in, 358 teratomas of, 357-358 growth-retarded, placental infarcts and, 684 anatomy of, 341-342 torsion of, 350, 353-354 in fetu, cystic teratomas and, 558 benign rests and cysts in, 345-348 trophoblastic tumors of, 362 inadequate circulation to, 664-669 blood supply of, 342, 366 tuberculosis of, 128, 256, 389 hydatidiform mole and, 700, 702 carcinoma of, 359-361 tumors of lung maturiry, prenatal diagnosis of, 718 in situ, 359, 361 benign, 356-358 maturity of amniocentesis for, 718, 719-720 metastasis to ovary, 627, 632, 634 malignant, 358 respiratory distress syndrome in, prenatal Crohn's disease of, 352 Wolflian adenoma of, 358 diagnosis of, 720-724 diagnostic methods for, 738-739 Farber's disease, prenatal diagnosis of, 714 Fever diverticula of, ectopic pregnancy and, 648 Farre-Waldeyer line, 368 from myoma degeneration, 3o4, 305 ectopic pregnancy in, 341, 362, 647-653, 779 Fat, in myometrial mesodermal tumors, 316 from tuberculous oophoritis, 389 ruptured, 650, 653 Fatty degeneration, in leiomyomata, 302, 305 Fiber cell, in carcinoma in situ, 758 endolymphatic stromal myosis of, 359 Female, duct development in, 6, 8-9 Fibrin endometriosis of, 354-355, 404, 409 Female genital tract, cytology of, 744-771 in corpus luteum, 367, 378 endosalpingiosis of, 355 Female pseudohermaphrodism, 10, 447-449 in oophoritis, 388 infertiliry from, 737-738 Female sex differentiation, 420-45 2 in ovarian cysts, 396 epithelial tumors of, 356 abnormal genetic disorders of, 421-429 in placental arteries, 680, 682-683 epithelium of, 343 abnormal gonadal rype, 421, 429-443 Fibrinolysin, in menstrual blood, 212-213 menstrual changes in, 344 gonadal dysgenesis in, 421 see Gonadal Fibrinolytic inhibitor, in placenta, 682 metaplasia, 343-344 dysgenesis Fibroadenomas fertilized ovum transport in, 735 hermaphroditism in, 421 in animals, 827, 828 fimbria! agglutination in, infertiliry from, 737 normal, 420-421 of cervix, 131, 140 foreign body reaction's in, 352-353 phenorypic abnormalities of, 443-449 Fibroblasts glial implants of, 358 pseudohermaphroditism in, 421 giant, in irradiated cervical tissue, 198 gross examination of, 778-779 Wolflian-Miillerian duct defects in, 421 in ovarian sex-cord-stromal tumors, 505, 506, hilus cells in, 358 Femoral artery, 15 511 histology of, 342-344 Femoral lymph nodes, 15 Fibroids, see Leiomyomata hydrosalpinx of, 349-350 Ferning reaction, of cervical mucus, 109, 736 Fibroleiomyosarcoma, of uterus, 335 infarction of, from abortion, 251 Ferret, genital tract tumors in, 836 Fibrolipoma, of vulva, 31 infertiliry originating in, 355-356 Fertilization Fibromas inflammatory diseases of, 347-353, 387 double, chimeras from, 431 in animals, 823, 824, 827, 830, 835, 847 intussusception of, 354 mechanism of, 638 in children and adolescents, 616 leiomyomatosis peritonalis disseminata in, 358 trypsin inhibitors in, 345 leiomyomata and, 299 ligation of, salpingitis following, 347-348 Fetal teratoma, 597-600 of ovary, 5o6, 513-514 lymphatics of, 342, 368 a-Fetoprotein ( AFP) of vagina, 73 lymphomas of, 362 biochemical properties of, 545 of vulva, 30 mesodermal tumors of, 356 in endodermal sinus tumors, 544-546 Fibromyolipoma, of myometrium, 316 mesotheliomas of, 319, 356-357 in sera of patients with, 539, 592, 594 Fibromyomata, 809 metastatic cancer of, 290 as prenatal indicator of congenital in animals mucosal membrane of, 342-343 malformations, 713 induced, 809, 810 nerves of, 342 Fetus spontaneous, 827, 828, 830, 836 nourishment of fertilized ovum by, 735 abnormalities of of vagina, 73 papillary adenofibroma of, 139 abortion and, 692, 793, 794 "Fibromyxosarcoma," in sow, 833-834 pathology of, 341-364 amnionic bands and, 656 Fibrosarcomas physiology of, 344-345 chorangioma and, 668 in animals, 827, 833, 838 pinworm infections of, 352 prenatal diagnosis, 713-718 in children and adolescents, 616 prolapse of, 353-354 aborted, congenital anomalies in, 692, 793, 794 of uterus, 323 resection of, 355 as allograft, 698, 709 of vulva, 51 reanastomosis, 355-356 amniotic fluid studies on, 710-733 Fibrous polyps, of cervix, 131

874 Index

FIGO staging granulomata to, 128, 604 Genital tract (female) of cervical carcinoma, 171, 172, 179 Foreign bodies, in fallopian tube, 352-353 congenital malformations of, 1-12 of endometrial carcinoma, 289-290 Fornices, 59 embryology of, 1-12 of vulvar melanoma, 49-50 aspiration of, for cytology study, 770 , 9 of vulvar squamous carcinoma, 47 Fourchette, 14 Genitalia, abnormal, sex chromatin analysis of, Filarial parasite, in placental blood, 671 Fowl 428 Fimbria( e) genital tract tumors in Geographic factors, in cervical carcinoma, 177 of fallopian tube, 341 induced, 804 Gerbil, genital tract tumors in, 827, 836 agglutination of, 737 spontaneous, 800, 825, 845 Germ cell tumors (ovarian), 527-585 ovarica, function in ovum pickup, 344 Fox-Fordyce disease, 25 in children and adolescents, 588, 589-606 Fistula histopathology of, 28, 29 choriocarcinomas, see Choriocarcinomas abdominal, from leiomyoma degeneration, 305 Fox terrier, ovarian tumor in, 854-855 classification of, 5 27-5 28 from cervical carcinoma, 179, 186 Freckles, 35 in dogs, 846, 856 tubal, 352 Freemartins, origin of, 5 dysgerminomas, 528-538 Fixative, for fetoplacental tissue, 795 Frei test, 17 embryonal carcinomas, 546-548 Fluorenylacetamide (FAA), tumor induction by, Frenulum, of clitoris, 13, 14 endodermal sinus tumors, 538-546 in animals, 801, 811 Friend leukemia virus, animal tumors from, 812 mixed, 568-569 Fluorenyldiacetamide, tumor induction by, in Frog, ovarian tumors in, 838 in children and adolescents, 606 animals, 811 nFrozen pelvis," from endometrial stromal pol yembryomas, 548-5 50 5-Fluorouracil sarcoma, 328 sex cord stroma mixed with, 568, 569-575 for therapy of Frozen section examination, of endometrial sex cord stromal tumors mixed with, 575-579 cervical carcinoma, 186 curettings, 77 3 teratomas, 552-568 endodermal sinus tumors, 545 FTA-ABS test, for syphilis, 20-21 Germ cells Foam cells, in teratomas, 604 Fucosidosis, prenatal diagnosis of, 714 and, 505 Folded index, for cytohormonal evaluation, 767 Fungae, in aborted fetus specimens, 790 sex cord-stromal tumors mixed with, 575-579 Folic acid deficiency, cytological effects of, 762- Fungal infections, of endometrium, 257 Germinal epithelium, 3 763 Funisitis, acute, 670 tumors of, 453-504 Follicle lutein cysts, in children and adolescents, Germinal layer, of follicles, 377 620-621 Germinal spot, 377 Follicle-stimulating hormone (FSH) G bands, of chromosomes, 421, 428, 439, 441 Germinal vesicle, 377 follicle hyperplasia from, 377 Galactocerobroside /3-galactosidase, in prenatal Germinomas, see Dysgerminomas in genetically altered mice, 802 diagnosis, 716 Gestation, cervical polyps in, 131 in menstrual cycle, 208-209 Galactosemia, prenatal diagnosis of, 715 Giant cells overproduction of, endometrial carcinoma and, Galactose-1-phosphate uridyl transferase, in in bizarre leiomyomata, 307, 308 279 prenatal diagnosis, 715 cytology of, 746 in polycystic ovarian syndrome, 401, 402, 740 /3-Galactosidases, in prenatal diagnosis, 715 in embryonal carcinomas, 547 releasing factor, 208, 739 Gallbladder, carcinoma of, metastases, 202, 627, foreign body reactions of, 24, 181, 182 Follicles, 368, 371 631 in leiomyosarcomas, 324, 326-328 adenocarcinoma of, 604 Ganglioneuroma of mixed MUllerian tumors, 335 atretic, 372, 378, 379, 383, 399, 741 of cervix, 138 in tuberculous salpingitis, 351 in mice, 798 in children and adolescents, 616 Gland ostia, of endometrium, 234, 237 blood supply of, 366 Gangliosidoses, prenatal diagnosis of, 715 Glandular epithelium, of endometrium, 226-232 cysts of, 394-396 Gangrene, from torsion of pedunculated Glandular hyperplasia, see Endometrial hyperplasia bacterial infection, 388 leiomyoma, 305 Glandular hypersecretion, from oral contraceptives, in children and adolescents, 618-620 Gartner's cysts, 7, 8, 28 133 growth and maturation of, 208-209, 377-378 histopathology of, 70, 72 Glial implants, in fallopian tube, 358 gross examination of, 779 paratubal, 346 ((Glioma ovarii," 604 in mixed germ cell tumors, 578 of vagina, 70, 72 Gliomas, of cervix and endometrium, 135, 136 in oophoritis, 387 Gastrointestinal tract Globoid cell leukodystrophy, prenatal diagnosis of, rupturing, fimbriae alignment over, 344 carcinoma of, metastasis to ovary, 627, 628, 716 structure of, 375, 377-378 631 Glomerular bodies, in clear cell carcinomas, 482, Follicular cervicitis, 112 endometriosis of, 404, 416-417 484 , 377, 378 Gaucher's disease, prenatal diagnosis of, 715 Glomerulus, 4 Follicular salpingitis, 348 Gemsbok, genital tract tumors in, 827 cells resembling, in endodermal sinus tumors, Fo!liculome lipidique of Lecene, 506, 517 Genetic deletion, ovarian tumor induction by, in 542 Fontana-Masson stain, for melanin, 46, 200 experimental animals, 802 Glucocerebrosidase, in prenatal diagnosis, 715 Forearm, endometriosis of, 405 Genital ducts, development of, 5-9 Glucose-6-phosphatase, in endometrial epithelium, Foreign body giant cells Genital ridges, 1, 2, 3 238, 240 in dysgerminomas, 533 Genital swellings, 9 Glucose-6-phosphate dehydrogenase

875 Index

Glucose-6-phosphate dehydrogenase [cont.] cystic teratoma with, 601 Granulomatous lesions, in tuberculous cervicitis, in endometrial epithelium, 238, 240 dysgerminomas in, 537, 538, 575, 591-592 128 in I uteinized ovarian tumors, 500 embryological basis of, 4-5 Granulomatous oophoritis, 389-392 in X-linked chromosome marker studies, of endodermal sinus tumors with, 594 Granulomatous salpingitis, etiology and histology cervical lesions, 156, 157 gonadoblastomas in, 538, 569-5 75 of, 350-353 Glucose tolerance infertili ry in, 741 "Granulosa cell islands," in canine ovaries, 85 5- abnormal mixed, 443 856 with endometrial hyperplasia, 265 mosaicism and, 436-438, 443 Granulosa cell tumors ( GCT) from Leydig (hilus) cell tumor, 615 possible inheritance of, 442 in animals, 798, 801, 802, 827, 833-856 ,8-Glucuronidase deficiency, prenatal detection, 714 "pure," 442-443 in children and adolescents, 611-612 Glutamine, in prenatal diagnosis, 716 vaginal smear cytology of, 769 of ovary, 506-511 Glutaraldehyde solution, for tissue studies, 773, Gonadal primordia, embryology of, 2-4 in postmenopausal women, 770 795 Gonadoblastomas, 507, 508, 568, 569-575, 578 Granulosa cells Glycine, in prenatal diagnosis, 716, 717 clinical aspects of, 570 immature, in gonadoblastomas, 569 Glycogen endocrine aspects of, 574-575 luteinization of, 210 in Brenner tumors, 489 familial aspects of, 57 5 of follicles, 375-379 in cervical hyperkeratosis, 125 genetic aspects of, 57 5 in cysts, 394, 395 in clear cell adenocarcinomas, 89, 95, 181, 194, germ cell tumors compared with, 578-579 of polycystic ovary, 399 195 incidence of, 570 in sex cord-stromal tumors, 505-516 in clear cell carcinomas, 296, 485-487 macroscopic appearances of, 570 of theca lutein cysts, 397 decrease of, in cervical intraepithelial neoplasia, microscopic appearances of, 571-574 Granulosa-stromal cell tumors, of ovary, 505-516 148, 163 mixed tumors of, 5 28-5 30, 534, 538, 546, 554, Granulosa-theca cell tumors in dysgerminomas, 531-532 567 in animals in endometrial carcinoma cells, 281, 286, 287 prognosis of, 57 4 induced, 801 in endometrial epithelium, 230-232, 238, 240 terminology of, 569-5 70 spontaneous, 806 in endometrial stromal cells, 220 therapy of, 574 in children and adolescents, 612, 616 of hymeneal membrane, 14 in 45X mosaicism, 438, 575 endometrial carcinoma! with, 276, 588 lack of, in mesonephric cysts, 122 Gonadotropin( s). (See also Chorionic Green soap, abortion from, infections following, in navicular cells, 770 gonadotropins) 251 in ovarian cells, 369 elevated levels of, from ovarian neoplasms, 588, Gridley stain, for fungi, 256 in portio epithelium of cervix, 104 804 Grocott stain, for fungi, 256 in prosoplastic epithelium, 117, 188 in experimental animals with ovarian tumors, t~Ground-glass" tubal discharge of, 344 802, 803 appearance, of herpetic nuclei, 19, 752 Glycolipids, in cancer-cell surfaces, 285 in gonadal dysgenesis, 442 viral inclusions, in herpesvirus-infected cells, Glycogen storage diseases, prenatal detection of, in ovarian failure, 741, 742 128 715 in polycystic ovarian syndrome, 402 Guinea pig Glycolipids, in prenatal detection, 716 releasing factors for, 208 cervical cytology of, 808 Glycoproteins theca I utein cysts from, 398 female reproductive tract in, 798, 799 in cancer-cell surfaces, 285 therapy with, theca lutein cysts in, 397 genital tract tumors in in cervical mucus gel, 108 in Turner's syndrome, 433 induced, 807, 809, 812 in endometrial glandular epithelium, 226 Gonocytomas. (See also Gonadoblastomas) spontaneous, 805, 835 Glucose-6-phosphate dehydrogenase, deficiency of, classification of, 569 Gull, ovarian tumor in, 838 prenatal diagnosis, 715 Gonorrhea(!) Gumma, syphilitic, of cervix, 129 a-1, 4-Glucosidase, in prenatal diagnosis, 715 cervical neoplasia and, 150 Gynandroblastoma, of ovary, 506, 5 23 ,8-Glucuronidase endometritis, 251 Gynecologic pathology, clinical aspects of, 243- in endometrial epithelium, 239, 240 of fallopian tube, 251, 347 248 in prenatal diagnosis, 716 of vagina, 63 Gynecologic smear Goat, genital tract tumors in, 824, 833, 837 Granular cell tumor, of vagina, 73-74 contaminants in, 748 Goblet cells, in mucinous ovarian tumors, 469, Granulocytes, in menstrual cycle, 251 epithelia! cells of, 744-7 46 470-472, 568 Granulocytic leukemia, 201 hormonal cytology of, 767-770 Golgi apparatus Granuloma gravidarum, of cervix, 138 methods for, 770 in endocervical cells, 109, 111 Granuloma inguinale, 25 nonepithelial components of, 746-748 in endometrial glandular cells, 227 · cervical carcinoma and, 185 in nonmalignant disorders, 748-755 in endometrial stromal cells, 233 of cervix, 129 normal components of, 744-748 in malignant cells, 285, 286 histopathology of, 17, 22, 23 numerical indices used in hormone studies, Gonadal dysgenesis, 421 Granuloma pyogenicum, of cervix, 137-138 767 autosomal chromosomal abnormalities in, 440- Granulomata, Haemophilus vagina/is infections and, Gynecologic tissue, description and processing of, 442 68 772-796 chromosome disorders in, 432-443 Granulomatous endometritis, 256 Gyriform pattern, in granulosa cell tumors, 509

876 Index

Haemophilus vagina/is, histopathology and in polycystic ovarian syndrome, 402 endometrial carcinoma and, 278-279 diagnosis of, 63, 68 Hermaphrodites, 16, 421 endometrial hyperplasia and, 265-266 Hailey-Hailey disease, of vulva, 26 chromosomal studies of, 430-432 Hormone receptors, 209 Hair dysgerminomas in, 53 7 factors affecting, 241 in cervical mucosa, 122 true, 429-432 Hormones. (See also Sex hormones) lack of, in testicular feminization, 444, 445 Hernial sacs, endometriosis of, 404 abnormalities of, with ovarian neoplasms, 587- "Hair balls" in cystic teratomas, 601 Herpes genitalia 588 Hairline, in Turner's syndrome, 433-436 cytological diagnosis of, 752-753 cytological studies on, 767-770 "Halo," in cells of tissue inflammations, 753-755 histopathology of, 17, 18-19 embryonic, 5 Hamartomas Herpes simplex virus, 17, 18-19 of menstrual cycle, 206-210 in cows, 830 cytological identification of, 752-754 role in genitalia development, 9-10 mesodermal tumors as, 316 Herpes simplex virus rype 1 (HSV-1), cervical Horse, spontaneous genital tract tumors in, 805, Hamster, 804 infections from, 126, 131 823, 839-840 cheek pouch of, use in human tumor Herpes simplex virus type 2 (HSV-2) Hot flushes, from premature ovarian failure, 742 transplantation, 816 antibody to, in cervical cancer detection, 187 Huhner test for intrauterine sperm, 736 genital tract tumors in, 800 cervical cancer and, 178 Human chorionic gonadotropin, see Chorionic induced, 801, 803 in animal tumor models, 815-816 gonadotropins spontaneous, 827, 828, 835 cervical infections from, 126-128 Human placental lactogen, in polyembryomas, 549 Hares, ovarian tumors in, 836-839 cervical intraepithelial neoplasia and, 151-152 Hunter's syndrome, prenatal diagnosis of, 716 Hashimoto's thyroiditis virion of, 127 Hurler's syndrome, prenatal diagnosis of, 716 and, 563 Herpes vaginitis, cytological identification of, 754 Hyaline X-chromosome abnormalities and, 439 Herpetic cervicitis, 131 in cervical cylindromas, 196-197 HCG, see Chorionic gonadotropins Herpetic vulvitis, 18-19, 35 in embryonal carcinomas, 592, 593 Healing of Meyer, squamous epithelization of Hexestrol, prenatal exposure to, genital changes in endodermal sinus tumors, 540, 544 endocervix in, 115 from, 87 Hyalinization Hemangiomas Hexokinase, in endometrial epithelium, 238, 240 in gonadoblastomas, 573 in animals, 833, 834 Hexosamidases, in prenatal diagnosis, 715 of irradiated cervical cells, 198 of cervix, 137-138 Hexosaminidase, in prenatal diagnosis, 715 in leiomyomata, 301-303, 304 in children and adolescents, 616 Hexose monophosphate shunt, in endometrial Hyaluronic acid of fallopian tube, 356 epithelium, 240 in ovarian adenomatoid tumor, 497 Hemangiopericytoma Hidradenitis suppurativa, of vulva, 25 in prenatal diagnosis, 717 of myometrium, 310-312, 776, 777 Hidradenomas, of vulva, 31-33 Hydatid cysts, of cervix, 129 of vulva, 30 Hilus cells, (See also Leydig cells) Hydatid of Morgagni, histology of, 346 Hematoma, from ectopic abortion, 650 nests of, in tubal fimbrae, 358 Hydatidiform mole, 692, 694 Hematosalpinx, in tuberculous salpingitis, 351 Hilus (Leydig) cell tumor abortion of, 695 Hematoxylin stain, for cervical tissue, 170 in children and adolescents, 612, 615 tissue examination, 773 Hematuria of ovary, 506, 520 as choriocarcinoma precursor, 705 from cervical cancer, 178 Hinselmann test, 167 of fallopian tube, 362 in endometriosis, 406 Hirsutism, polycystic ovaries and, 401, 402 incidence of, 702 Hemolytic anemia Histiocytes pathogenesis of, 698-704 from cystic anemia, 558, 560 cytology of, 746-747 theca lutein cysts with, 397 inborn error for, prenatal diagnosis, 715 in endometritis, 252 trophoblastic disease following, 704 with ovarian neoplasms, 587, 601 in tuberculous endometritis, 256 Hydramnios, 656 Hemoperitoneum, from tubal pregnancy, 650, 653 Histiocytic lymphomas, of cervix, 201 chorangioma and, 668 Hemophilus ducrey, as cause of chancroid, 17, 23 Histiocytomas, of vulva, 31 Hydrocephaly, in aborted fetuses, 692 Hemophilus vagina/is, in cervico-vaginal smears, Histology, of cervical carcinoma, 173-175 Hydrocoele, of spermatic cord, 28 Hemorrhage Hobnail cells Hydronephrosis, from cervical carcinoma, 187 from abnormal placentas, 646, 647 in clear cell adenocarcinomas, 89, 90, 295 Hydrops fetalis, in erythroblastosis fetalis, 668, 669 from myoma red degeneration, 304, 305 in ovarian neoplasms, 456, 464, 465, 467, 468, Hydrorrhea, 664 postpartum, from adenomyosis, 314 483, 484 Hydrosalpinx, 360, 739 Hemorrhagic infarct, of ovary, 623 Hodgkin's disease, 201 etiology and histology of, 349-350, 351, 353, Hemosiderin of endometrium, 297 354 in endometriomas, 477 Hofbauer cells, of placenta, 642-643 Hydroureter, from cervical carcinoma, 187 in teratomas, 604 Homocystine, in prenatal diagnosis, 717 12-Hydroxydimethylbenzanthracene, ovarian tumor Hens, genital tract tumors in, 800, 804, 825, 845 Homocystinuria, prenatal diagnosis of, 716 induction by, in animals, 800 Heparin sulfate, in prenatal diagnosis, 717, 718 "Honeycomb" arrangement, of endocervical cells, 5-Hydroxyindoleacetic acid Heparitin sulfate, in prenatal diagnosis, 716 745, 746 abnormal levels, with ovarian metastatic cancer, Heredity Hormonal activity, of gynecologic tumors, 48 632 of adenomyosis, 314 Hormone imbalance in carcinoid syndrome, 564

877 Index

17-Hydroxylase, deficiency of, in male for cervical neoplasia, 160, 171, 172, 175, 177, Inducer substance, 10 pseudohermaphroditism, 447 186, 187, 195 Infants. (See also Newborn) 17a-Hydroxy-Ll5-pregnenolone, in menstrual cycle, effect on, , 70-71 "dysmature," placental lesions and, 671 208 for endometrial carcinoma, 290, 291 follicle cysts in, 618-620 20,8-Hydroxypregn-4-en-3-one, in bovine ovarian for endometrial carcinoma in situ, 275 vaginal carcinoma in, 76-79 tumor, 841 for endometrial stromal myosis, 330 vaginal polyps in, 73 17a-Hydroxyprogesterone for leiomyomata, 305-306 vaginal sarcomas in, 79-83 in bovine ovarian tumor, 841 for leiomyosarcomas, 328 Infection, of cystic teratoma, 558 in menstrual cycle, 207-209 for lymphomas, 340 Infectious diseases, of vulva, 16-24 3,8-Hydroxysteroid, deficiency of, in male metastatic endometrial carcinoma after, 259-260 Inferior vena cava, 368 pseudohermaphroditism, 447 for mixed MUllerian tumors, 339 Infertility Hyena, genital tract tumors in, 828 pregnancy following, 650 in atypical adenomatous hyperplasia, 270 , 14 tissue processing after, 774-778 from cervical abnormalities, 736-737 imperforate, 16 tubal prolapse after, 354 disease processes in, 735-742 infertility from rigidity of, 736 Hysterogram, in diagnosis of Asherman's endometrial biopsy for, 247 Hyperammonemia, prenatal diagnosis of, 716 syndrome, 73 7 with endometrial carcinoma, 278 Hypercalcemia, from gynecologic tumors, 48 Hysterosalpingography from endometrial disease, 249, 25 7 Hyperestrinism foreign body introduction by, 352-353 from endometriosis, 406, 408 from granulosa cell tumors, 511 in infertility studies, 738 "estrogen carcinoma" with, 276 from luteinized ovarian tumors, 501 Hysteroscopy, in diagnosis of Asherman's from gonadal dysgenesis, 7 41 Hyperkeratosis, of cervix, 125, 127 syndrome, 737 immunologic aspects of, 734, 735 Hyperlysinemia, prenatal diagnosis of, 716 from inadequate corpus lureum function, 246 Hypermenorrhea, from ovarian tumors, 587 from leiomyomata, 300 Hypernephroma, in cow, 840 I cell disease, prenatal diagnosis of, 716 from ovarian abnormalities, 739-742 Hyperparathyroidism, from ovarian neoplasms, 587 Ichthyosis pathologic factors in, 734-743 Hyperplasia in senile endometritis, 254 physiologic factors in, 734-735 of endometrium, 265-277 squamous cell carcinoma following, 294 from premature ovarian failure, 741-742 microglandular a-L-Iduronidase, in prenatal diagnosis, 716, 718 from salpingitis isthmica nodosa, 353 of endocervix, 131 Ileum, endometriosis of, 416 semen analysis for, 736 in vaginal adenosis, 91 Iliac arteries, 15 in Stein-Leventhal syndrome, 401 pseudoepi theliomatous of cervix, 129 Iliac lymph nodes, 15, 61, 103 from tubal endometriosis, 354 subcolumnar reserve cell type, 116-117 metastatic cancer of, 290 of tubal origin, 355-356 Hyperplastic , of vulva, 36-38 tubal drainage to, 342 in tuberculous endometritis, 256 Hyperreactio luteinalis, 702 Immunocompetence, cervical cancer prognosis vaginal abnormalities in, 736 Hypertension and, 186-187 Inflammatory cells abruptio placentae and, 667 Immunoglobulins, in tubal physiology, 345 in endometrial carcinomas, 285 with clear cell endometrial carcinoma, 294 Immunology in nonmalignant disorders, 748-755 with endometrial carcinoma, 278, 279 of abortion, 691-692, 694 Inflammatory diseases with endometrial hyperplasia, 265 of fetus, 698 of cervix, 124-142 placental changes from, 645, 666, 684 of infertility, 735, 736 cytology of, 748-755 in toxemia of pregnancy, 668 of ovarian tumors, 807-808 of endometri urn, 249-2 57 H yperthecosis, 398-402 in premature ovarian failure, 741-742 of fallopian tube, 347-353, 387 Hyperthyroidism, from ovarian neoplasms, 587, of toxemia of pregnancy, 689 of ovary, 387-392 604 Immunotherapy, of cervical carcinoma, 186 pelvic, from leiomyomata, 300 Hypervalinemia, prenatal diagnosis of, 716 Implantation of vagina, 63-70 Hypogastric lymph nodes, 103 abnormal sites of, 646-655 of vulva, 24-26 endometriosis of, 405, 407 inception of blood supply after, 675 Infundibulopelvic , 368 Hypoglycemia, from ovarian neoplasms, 587 mechanism of, 638, 735 Infundibulum, of fallopian tube, 341 Hypospadias, in hermaphrodites, 429, 430, 446 Implantation theory, of cervical endometriosis, Inguinal hernia, in hermaphrodites, 430 Hypothalamus 141 Inguinal lymph nodes, 15 destruction of nucleus of, placental tumor Inborn metabolic errors, prenatal diagnosis of, Inguinal region, endometriosis of, 404 induction by, in animals, 812 713, 714-718 Injection apparatus, for fetal vessel study, 794, 795 in hormone regulation, 208, 211 Incisional scars, endometriosis of, 404, 409 Injection method for fetal vessel studies, 794-796 role in anovulation, 737 Inclusion cysts "Ink dot" karyopyknotic nucleus, of superficial Hypoxanthine-guanine phosphoribosyltransferase, of fallopian tube, 346 cell, 745 in prenatal diagnosis, 717 of ovary, 371, 393, 394, 455 Insects, ovarian lesions in, 839 Hysterectomy India ink Instruments, for grossing room, 795 for adenomyosis, 312 for tissue examination, 774, 781, 795 Insular pattern, in granulosa cell tumors, 509 for adenosquamous endometrial carcinoma, 294 for vulvar biopsies, 53 Intercalary cells, of tubal epithelium, 343

878 Index

lnteriliac lymph nodes, 15 Jellies, lubricant and anti conceptuals, as smear , 9, 10, 13, 14 lnterlabial sulcus, !4 contaminants, 748 cysts of, 27, 28 Intermediate cells Jet wash, for endometrial cells, 770 fusion of, 16 of cervix, 105, !o6 Jews gangrene of, in Behcet's syndrome, 25 cytology of, 745 circumcision and cervical neoplasia in, 150 majora atypias, 748 endometrial hyperplasia and carcinoma in, 266 basal cell carcinoma of, 50 cytolysis of, 750 Juvenile gangliosidoses, prenatal detection of, 715 breast tissue in, 31 hormone effects on, 767 Juvenile granulosa cell tumor, in children, 511 sarcomas of, 51 Intestine minora endometriosis of, 416 of, 16 tumors of, 300 Karyolysis, of epithelial cell nuclei, 749, 761 sebaceous glands of, 14 Interstitial ectopic pregnancy, 653 Karyopyknotic index, for cytohormonal ulcers of, 25 Intraepithelial neoplasia, of cervix, evaluation, 767 nerves of, 16 Intrasplenic ovary grafting tumor induction by, in Karyorrhexis, 85 2 tumors of, 30 experimental animals, 802-803 of epithelial cell nuclei, 749, 761 Labioscrotal fusion, in testicular feminization Intrauterine contraceptive devices Keratin variant, 449 actinomycosis from, 129, 352 in adenosquamous endometrial carcinoma, 293, Labor acute salpingitis aggravation by, 347 295 cervical changes during, 103, 120 cervical neoplasia and, 150 in endometrial adenocanthoma, 292, 293 cervical lacerations in, 121 ectopic pregnancy from, 650 Keratinizing carcinomas, of cervix, 180-181, 188, myometrium in, 299 endometrial actinomycosis and, 25 7 189 prolonged, endometritis following, 250 endometritis from, 251-253 Keratinizing metaplasia, in animals, 827 teratoma interference with, 559 penetration of myometrium by, 252 Keratinosomes, in cervical epithelial cells, 106 Laboratory animals, spontaneous genital tract tuboovarian abscess from, 349 Keratinous cysts, of vulva, 27 tumors in, 825-827, 834-836 tumor induction by, in animals, 811 Keratoacanthomas, of vulva, 34 Labrador retriever, ovarian tumors in, 850 Intravenous leiomyomatosis, 326, 327 Keratohyaline granules, in superficial cells, 745, Lactate, in oviductal fluid, 345 histology and diagnosis of, 307, 309-310 746 Lactic dehydrogenase Invasive mole, 698, 699, 700, 702 Keratosis follicularis, see Darier's disease in endometrial epithelium, 239, 240, 241 induction of, in animals, 812 Kernicterus, in erythroblastosis fetalis, 668 in luteinized ovarian tumors, 500 metastasis of, 705 17-Ketosteroids Lactosyl ceramidosis, prenatal diagnosis of, 716 pathogenesis of, 704-705 elevated Langhans giant cells Involution, of placental site, 645 from gonadoblastomas, 574 in dysgerminomas, 591 Iodine, as stain for vaginal and cervical from Leydig cell tumors, 615 in tuberculous cervicitis, 128 abnormalities, 95 in granulosa cell tumors, 612 in vulvar tuberculosis, 23 Iodine-131, animal tumor experiments using, 804 in polycystic ovarian syndrome, 401, 402 Laparoscopy Iodine test, for cervical lesions, 168 Serroli-Leydig cell tumors and, 517 for endometriosis diagnosis, 409 Iron pigment, release from endometrioma, 409, Ketotic hyperglycinemia, prenatal diagnosis of, 716 in infertility studies, 738, 739 413 Kevorkian cervical biopsy punch, 161 Larynx, papillomas of, in newborn, 18 Irradiation, see Radiation therapy Kidney Lecithin-sphingomyelin ratio, in prenatal diagnosis Isoantigens, absence of, in cervical carcinoma, 187 abnormalities of of respiratory distress syndrome, 720-722 Isochromosomes in Turner's syndrome, 435 Leiomatosis peri tonalis disseminata, of fallopian abnormalities from, 427-429, 440 carcinoma of tube, 358 formation of, 428 in animals, 804 Leiomyoblastoma, see Clear cell leiomyomata Isocitric dehydrogenase metastases, 51, 83, 632, 636 Leiomyomata, 251, 299-312, 774, 778 in endometrial epithelium, 239, 240 endometriosis of, 404 abortion from, 692, 737 in luteinized ovarian tumors, 500 metastatic carcinoma of, 328, 708 in animals Isoleucine, in prenatal detection, 717 "Kidneybean" -shaped cells, of cervical histiocytic induced, 801, 810 Isoleucine catabolism disorder, prenatal diagnosis lymphoma, 201 spontaneous, 823, 824-828 of, 716 Kidney-shaped nuclei, in histiocytes, 747 bizarre, 307, 326 Isosexual precocity ~tKnotting," of syncytiotrophoblast, in toxemia, blood vessels in, 301 from granulosa cell tumors, 506 667 cellular, 307-309, 311, 326 from Sertoli-Leydig cell tumors, 517 Koala, ovarian tumors in, 83 7 of cervix, 131-137, 140 Isthmus Koebner phenomenon, in psoriasis, 26 infertility and, 7 37 anatomy of, 103, 104, 342 Krabbe's disease, prenatal diagnosis of, 716 clear cell type, 306-307 ectopic pregnancy in, 65 3 Kraurosis vulvae, 36 clinical aspects of, 300 , 628-630 degenerative changes in, 301-302 absence of primary site for, 632 ectopic pregnancy and, 648 Jaguar, genital tract tumors in, 828 ovarian carcinoid compared to, 566 endometrial polyps and, 301 Jejunum, endometriosis of, 416 virilism from, 63 7 epidemiology of, 300

879 Index

Leiomyomata [cont.} Lichen simplex chronicus, 38 Luteinizing hormone (LH) of fallopian tube, 356 Ligaments, uterine, endometriosis of, 404 in experimental ovarian tumor induction, 803 gross and microscopic appearance of, 300-305 Light, noncyclic exposure to, experimental tumor in genetically altered mice, 802 intramural, 300, 301 induction by, in animals, 804 in menstrual cycle, 206-209 leiomyosarcomas in, 323-325, 328 Lion, genital tract tumors in, 827, 828 overproduction of, endometrial carcinoma and, mesodermal tumors with, 316 Lipid(s) 279 metastasizing, 309-311 in abnormal uteroplacental vasculature, 685-687 in polycystic ovarian syndrome, 402, 740 nuclear palisading in, 301, 302 in dysgerminomas, 532 releasing factor, 208, 739 pedunculated, 300, 305 from endometrial adenocarcinoma cells, 281, 285 in trophoblast disease, 704 placenta accreta from, 647 in endometrial epithelium, 239 Luteomas pregnancy and, 300, 301 errors of metabolism of, prenatal diagnosis, 713 in animals, 805-807 secondary infections of, 305 in luteinized ovarian tumors, 500 in children and adolescents, 612 submucosal, 300-302 in ovarian histiocytes, 389 Lymph nodes subserosa!, 300, 306 in ovarian stromal cells, 374 choriocarcinoma in, 708 treatment of, 305-306 in sclerosing stromal tumor, 514 involvement of, in cervical carcinoma, 172, 175, of vagina, 73 in Sertoli cell tumor, 506, 517, 518 177, 186, 195 vascular, 306, 309, 326 in thecomas, 511, 513 sectioning of, 55 of vulva, 30 Lipochrome pigment in vulvectomy specimens, 53-55, 781 Leiomyosarcomas from hilus cell tumors, 521 Lymphadenectomy, for cervical carcinoma, 177 in animals, 809, 823, 825-827, 830, 832, 833, in ovarian cells, 375 Lymphangiomas 836 Lipoid cell tumors, in anim.Js, 844-845 of cervix, 138 of cervix, 201 Lipoid hyperplasia, in male in children and adolescents, 616 in children and adolescents, 616 pseudohermaphroditism, 447 of fallopian tube, 356-357 of fallopian tube, 361 Lipomas of myometrium, 317, 319, 320 hemangiopericytomas and, 311 in animals, 830 of ovary, 497 intravenous leiomyomatosis and, 309, 310 of cervix, 138 Lymphatic system in mixed tumors, 317, 554, 560, 606 of fallopian tube, 356 carcinoma spread to ovary by, 635 of uterus, 305, 307, 323-328, 335, 336, 776 of myometrium, 316 of cervix, 103 of vagina, 80 of vulva, 30-31 in endometrial adenocarcinoma metastasis, 290 of vulva, 51 Liposarcoma, of uterus, 323, 335, 338 endometriosis of, 404-407, 475 Leisegang colposcope, 167 Listeriosis, of placenta, 669, 671 endometrium dissemination by, 405-408, 475 Lentigo, of vulva, 35 Liver, metastatic cancer of, 260, 261, 291, 328, of fallopian tube, 342 Leopard, genital tract tumors in, 827 536, 544, 554, 708, 709 metast;ltic cancer of, 339 Leopard syndrome, 3 5 Loeffler's media, for TBC culture, 790 of myometrium, endolymphatic stromal myosis Leptothrix, vaginal infections and, 68 Lubricant jelly, as tubal foreign body, 352 of, 316 Lesch-Nyhan syndrome, prenatal diagnosis of, 717 Lung of ovary, 368, 369 Leucine, in prenatal detection, 717 amniotic fluid embolism of, 662, 663 of vagina, 61, 63 Leukemia benign metastasizing leiomyoma of, 358 of vulva, 15 cervical infiltration of, 202 carcinoma of, metastases, 51, 627, 632, 636 Lymphedema, in Turner's syndrome, 434, 435 chronic myelogenous, drug therapy of, cytology, clear cell adenocarcinoma metastases to, 93 Lymphocytes 763 endometriosis of, 404, 405 in endometritis, 252 in endometrium, 297 of fetus, prenatal diagnosis of maturity of, 718, in tubal epithelium, 343, 344 of genital tract, 340 720-724 Lymphocytic lymphoma, of cervix, 201 Leukemia virus, animal tumors from, 812 metastatic cancer of, 187, 260, 261, 290, 291- Lymphogranuloma venerum (LGV), 25, 128 Leukocytes, in cervico-vaginal smear, 747-748 292, 328, 339, 536, 544, 554, 708 cervical carcinoma and, 185 Leukoderma, of vulva, 3 5 metastasizing leiomyoma in, 309-311 of cervix, 129 Leukokeratosis, reactive, 38 Lupus erythematosus, 21 histopathology of, 17, 22-23 Leukoplakia placental infarcts and, 667 Lymphoma in exocervical hyperkeratosis, 125 Lutein in animals, 815 of vulva, 36, 38 in germ cell mixed tumors, 576 of fallopian tube, 362 Leukorrhea, from endocervical polyps, 131 in gonadoblastomas, 569, 572, 575 of genital tract, 340 Leydig cells, (See also Hilus cells) Lutein cells malignant in fallopian tube, 358 antibodies in, ovarian failure and, 7 42 of cervix, 201 immature in corpus luteum cycle, 3 78, 380, 381 in children and adolescents, 616-619 in germ cell mixed tumors, 57 6 Lu rein cysts of uterus, 323, 339-340 in gonadoblastomas, 569, 572, 574, 575 in children and adolescents, 620-621 vulvar metastases, 51 in ovarian sex cord-stromal tumors, 505 ovarian enlargement from, 702 ovarian metastases of, in animals, 807, 842 in ovary, 368, 375, 376 Luteinized cells, in thecomas, 513 Lymphosarcoma Lice, vulvar infections by, 24 Luteinized follicle cysts, in infants and children, in animals, 828, 830 Lichen sclerosus, of vulva, 36-3 7, 38-40 618-620 of endometrium, 297

880 Index

of genital tract, 340 syndrome resembling, 563 endocervical changes in, 108, 110 Lyon hypothesis, of cervical neoplasia, 15 7 Meiosis endometrial enzymes in, 238-239 "Lyonization" of X chromosome, 443 of germ cells, 422-424 endometrial polyps in, 258-259 Lysine, in prenatal detection, 716 nondisjunction in, 425 endometriosis and, 406, 409, 416 Lysine-ketoglutarate, in prenatal detection, 716 schematic, 423 hormones of, 206-210 Lysosomal acid phosphatase deficiency, prenatal Melanoma, 46 irregularities of diagnosis of, 717 cutaneous, metastasis of, 627 with endometrial carcinoma, 278 malignant with endometrial hyperplasia, 265 of cervix, 200, 202 in Stein-Leventhal syndrome, 401 Mackenrodt's ligaments, 103 ovarian metastasis, 632, 635 from tuberculous oophoritis, 389 Macrofollicular pattern, of granulosa cell tumors, of ovary, 560, 606 from tuberculous salpingitis, 351 508-509 nevi transformation into, 36 maturation index in, 768 Macrophages, lipid-laden, from endometrial of vagina, 79 ovulation during, 739 carcinoma cells, 285 of vulva, 49-50 preovulatory phase of, 215-217 Malaria, 21 Melanotic rumor, of ovary, 568 prostaglandins in, 241 Male embryo Menarche, 206 secretory phase of, 286 duct development in, 6 age of, 225 spiral arterioles in, 213-214 sex differentiation in, 3 cervical epithelium changes in, 104 tubal epithelium changes in, 344, 350 Male pseudohermaphrodism, 10, 444-447 changes occurring in, 212-213 vaginal smear cytology of, 766, 768, 769 Malic dehydrogenase, in endometrial epithelium, endometrial hyperplasia after, 266 Mental retardation, in poly-X , 429 239, 240 germ cell tumors in, 587 Mercurochrome, for vulvar biopsies, 52-53 Malignant lymphoma, of uterus, 323, 339-340 ovary in, 384 Mesenchymal cells, mixed Mullerian rumors from, Malignant rumors vagina mucosa changes in, 62 331 of cervix, 171-205 vaginal smear cytology during period preceding, Mesenchymal sarcoma, 331 in endometrial polyps, 259-260 768 Mesenchymal rumors, 305, 331 of fallopian tube, 3 58 Meningitis, in newborn, from genital herpes, 753 , 2 of ovary, 453-637 Meningocoele, in aborted fetuses, 793 Mesentery, metastatic cancer of, 339 of uterus, 244, 322-340 Menopause Mesoblastoma, see Endodermal sinus tumor of vagina, 74-85 abnormal bleeding after, biopsy for, 246, 248 Mesoblastoma vitellinum, see Endodermal sinus of vulva, 31, 32, 46-51 anovulatory bleeding in, 261 tumor Mallard duck, ovarian tumor in, 838 cervical papillary adenofibroma in, 140 Mesodermal sarcomas, see Mullerian tumors Mammary tumors changing patterns of, 225 Mesodermal rumors, 122 in animals definition of, 225 benign, of myometrium, 316-319 induced, 803, 807 endometrial carcinoma after, 278 of fallopian tube, 356 spontaneous, in C3H mice, 815 endometrial hyperplasia in, 266 Mesonephric carcinoma, of cervix, 190, 195 Mannosidosis, prenatal diagnosis of, 717 endometrial polyps in, 25 7 Mesonephric cysts Maple syrup urine disease, prenatal diagnosis of, endometrium in, 220, 225 in cervix, 121 717 irradiation-induced, endometrial squamous histopathology of, 28 Marchand's adrenals, 589 carcinoma and, 294 . (See also Wolffian ducts and Marfan's syndrome, prenatal diagnosis of, 717 late, adenocanthoma and, 292 system.) Maroteaux-Lamy syndrome, prenatal diagnosis of, maturation index in, 768 clear cell carcinomas and, 296 717 mixed Mullerian tumors incidence after, 331 tubal cysts from remnants of, 345-348 Mast cells, in leiomyomata, 301 myomata diminution after, 306 vestigial, in cervix, 121-122 Mastomys, ovarian tumors in, 836 ovarian inclusion cysts after, 393, 394 , 3 Maternal age, chromosomal abnormalities and, 432 ovary in, 3 71 Mesonephroma, see Endodermal sinus tumor Maturation index, for cytohormonal evaluation, premature, causes of, 741-742 , 2, 3 767-768 "swiss cheese hyperplasia" in, 267 , 8, 342, 366 Mayer's mucicarmine, as stain for vulvar mucous vaginal mucosa changes in, 62 Mesothelium, of ovary, 368 cysts, 27 vaginal smear cytology of, 768-769 Mesothelioma, see Lymphangioma Meconium, 786 Menorrhagia , 365 effect on amnion, 656, 65 7 endometrial biopsy for, 246 parovarian cysts in, 393 Mediastinum, endodermal sinus rumors of, 538 from endometrial polyps, 25 7 torsion of, ovarian edema from, 621-623 Medullary adenocarcinoma, of cervix, 190, 192, uestrogen carcinoma" with, 276 Mesuprine, leiomyoma induction by, in animals, 196 from leiomyomata, 300 801 Medullary cords, 4 from ovarian tumors, 576, 589 Metachromasia, prenatal diagnosis of, 717 Megaloblastic anemia, cytological effects of, 762- Menstrual blood, fibrinolysin in, 212-213 Metachromatic leukodystrophy, prenatal diagnosis 763 Menstrual cycle, 251 of, 717 Meig's curette, 247 adenomyosis and, 312-314 Metaplasia, cervical, 125 Meigs syndrome corpus luteum and, 380 Metastases fibromas in, 513, 515 cytology of genital tract cells in, 746, 747 cell surface properties and, 285

881 Index

Metastases [cont.] ectopic tumors and, 31 Mucinous adenocarcinoma, of cervix, 190, 192- of clear cell adenocarcinomas, 92, 93 Paget's disease along, 44 194 of , 75-76, 79, 80 Mineral oil as tubal foreign body, 352 Mucinous degeneration, in leiomyomata, 302-304 to vulva, 51 Miniature, poodle, ovarian tumor in, 854 Mucinous glands, in Sertoli-l.eydig cell tumors, from vulvar squamous carcinoma, 47-48 Mites, vulvar infections by, 24 522 Metastasizing leiomyoma, 309-311 Mitochondria, ~~giant," in endometrium at Mucinous tumors Methionine ovulation, 230 of ovary, 454, 469-475, 568, 606, 779 in prenatal diagnosis, 716 Mitosis in children and adolescents, 607, 611, 612 Methotrexate description of, 422 Mucoepidermoid carcinoma, of cervix, 190, 1%, for therapy of nondisjunction, 422 197 cervical carcinoma, 186 schematic, 423 Mucopolysaccharides choriocarcinoma, 551, 709 Mitotic rates in cervical carcinomas, 196 , 53 7 in leiomyosarcomas, 326-328 of columnar epithelial cells, 108 as transplanted tumor suppressant, 816 in stromal sarcomas, 329-330 errors of metabolism of prenatal diagnosis of, Methylcholanthrene Mixed mesodermal tumors 713-718 endometrial adenocarcinoma from, 272 in animals, 842 in Paget cells, 45 genital tract tumor induction in animals by, of fallopian tube, 361 of , 3 77 814 of ovary, 454, 455, 495-497 Mucoproteins, of endocervical cells, 109, 110 ovarian tumors from, 588 teratomas and, 5 54 Mucosa tumor induction by, in animals, 801, 810-811 of uterus, 778 cervical, epidermidization of, 122 Methylmalonicaciduria, prenatal diagnosis of, 717 Mixed polyps, of cervix, 131, 133 endocervical, in pregnancy, 120-121 Methylmalonyl CoA isomerase, in prenatal Molar pregnancy, 698-705 Mucosal membrane, of fallopian tube, 342 diagnosis, 717 Molluscum contagiosum, histopathology of, 17, Mucous cysts, of vulva, 27 Methyltestosterone, in endometriosis therapy, 741 21 Mucous membranes, of vagina, 61-62, 64-67, 70 Methylthiouracil, animal tumor experiments using, Moloney's mouse sarcoma virus, placental tumor Mucous plug, of cervix in pregnancy, 120-121 804 induction by, in animals, 812 Mucous polyps, of cervix, 131, 132 Metropathia hemorrhagica, from granulosa cell Monilial infections Mucus tumors, 507 of cervix, 752 cervical, 108, 109 Metrorrhagia cytological diagnosis of, 75 2 formation, 111 endometrial biopsy for, 246, 248 of vagina, 68 in infertility, 736 from endometrial polyps, 25 7 of vulva, 23-24 Mucus-secreting cells, in ovarian neoplasms, 456 from leiomyomata, 300 Monkeys MUllerian adenosarcoma Meyer, ascending cervical healing of, 115 genital tract tumors in of cervix, 140 Mice induced, 810 of uterus, 339 cervical cytology of, 808, 809 spontaneous, 800, 805, 809, 825-826 MUllerian ducts, 6-10, 59 experimental, 797 Monophasic carcinoma, of cervix, 178 anomalies of, 10, 16 female reproductive tract in, 798, 799 , 13 cervical adenocarcinomas and, 195 genital tract tumors in absence of, 16 developmental defects of, 449 induced, 800-816 Morphea guttata, 36 ovarian epithelial tumors and, 453, 456, 461, spontaneous, 798-800, 805-807, 827, 834- Morquio's syndrome, prenatal diagnosis of, 717 469, 482, 483, 494, 497, 606 835 Morules, in atypical adenomatous hyperplasia, 270, remnants of immune-suppressed, tumor induction studies 273 cysts in, 346 on, 816 Mosaicism in testicular feminization, 444 Microcystic pattern, of endodermal sinus tumors, in aborted fetuses, 692 MUllerian epithelium, from ovarian cuboidal 539, 540 of chromosomes, 424, 426, 427 epi theli urn, 368 Microglandular endocervical hyperplasia (MEH) for monosomy X, 436-438 MUllerian rests histopathology of, 133-134, 192 in Turner's syndrome, 575, 741 adenomyomas as, 307, 405 in pregnancy, 121 Mucicarmine stain, for mucin, 281, 296 clear cell carcinomas as, 296 Microinvasive carcinoma Mucin mucous cysts as, 27 of cervix, 171-176 from cervical adenocarcinoma, 70, 96-98 MUllerian sarcomas, in children and adolescents, definition, 172 in cervical carcinomas, 190, 191, 196-197 616 Microridges, of portio epithelium, 107 from clear cell adenocarcinomas, 296 MUllerian stromal sarcoma, of vagina, 80 Miaotubules, in endometrial epithelium, 286 in cystic teratoma cysts, 601 MUllerian tubercle, 6 Microvilli from endometrial carcinomas, 281 MUllerian tumors, mixed, of uterus, 323, 331-339 in clear cell carcinomas, 296 in endometrial epithelium, 238, 240 Multiple sclerosis, 16 in endometrial carcinoma cells, 288, 289 in Krukenberg tumor, 629-630 Mumps, oophoritis with, 388 of endometrial cells, 234-238 lack of, in mesonephric cysts, 122 Munro abscesses, in psoriasis, 26 of ovarian cuboidal epithelium, 371, 372 from metaplastic tubal epithelium, 343 Mycobacterium tuberculosis ~~Milk line" in Nabothian cysts, 115 as cause of tuberculosis, 17, 23

882 Index

in tuberculous cervicitis, 128 cytology of, 745 Obesity in tuberculous salpingitis, 350-351 pregnancy and, 769 with clear cell endometrial carcinoma, 294 Mycoplasma in Stein-Leventhal syndrome, 770 with endometrial carcinoma, 278, 279 placental membrane infection by, 659 Neural tissue, in cystic teratomas, 601, 603, 604, with endometrial hyperplasia, 265 vaginal infections and, 68 605 Obstetric specimens, description and processing of, Mycoplasma hominis, in salpingitis etiology, 347 Niemann-Pick disease, prenatal diagnosis of, 717 772-796 Myelin figures, in cells, 286, Neisseria Bartholin abscess and, 27 Obturator lymph nodes, 15, 103 287 Neisseria gonococcus metastatic cancer of, 290 Myoblastomas endometritis from, 251 Occult invasive carcinoma, of cervix, 176-177 granular, of vagina, 73-74 as gonorrhea agent, 63, 124, 251, 347, 387, ~~oleokeratin" reaction, in cystic teratoma, 606 of vulva, 30 389 Oligohydramnios, 656, 659, 786 Myolipoma, of myometrium, 316 Nephritis, placental infarcts and, 666 Oligomenorrhea Myomata Nerves from ovarian tumors, 587 in animals, 827 of cervix, 103, 110 from Sertoli-Leydig cell tumors, 517 uterine, 246, 776, 777 of fallopian tube, 342 in Stein-Leventhal syndrome, 401 Myomectomy, indications for, 306 of ovary, 368 Omentum Myometrium of vagina, 61 metastatic cancer of, 339 adenocarcinoma penetration into, 279, 280, 285, of vulva, 15~ 16 tumor implant in, 779, 780 286, 287, 290, 293-295, 297 Neural tumors Oncocytic metaplasia, 343 adenomyosis of, 312-315 of fallopian tube, 356 Oncogenic virus arteriosclerosis of, 254 metastasis to ovaries, 632 Herpes simplex virus-2 as possible, 151-152 benign lesions of, 2°:J-321 Neuraminidase, possible existence in sperm, 735 tumor induction by in animals, 816 benign mesodermal tumors of, 316-319 Neuroblastoma, 599 Oocytes, 368, 375 endolymphatic stromal myosis of, 316 with Sertoli-Leydig cell tumor, 522 deficiency of, tumor development and, 798 function and anatomy of, 299 Neurodermatitis, of vulva, 38 newborn, 3 71 hemangiopericytoma of, 310-312 Neuroepi thelioma, 599 , meiosis in, 424 inflammation of, 249, 251 Neurofibromas Oophoritis leiomyomata of, 251, 299-312 of cervix, 138 acute, 387-388 leiomyosarcomas of, 328 of vagina, 7 3 causes of, 387 lymphangioma of, 317, 319, 320 of vulva, 31 chronic, 389 mixed Mullerian tumors of, 338 Neurofibrosarcomas, of vulva, 51 granulomatous, 389-392 plexiform tumorlets of, 319 Neuromyopathies, with ovarian neoplasms, 587 ((Oophoroma folliculate," see Brenner tumors sarcoidosis of, 391 Neuropathies, with ovarian neoplasms, 587 Opossum, gonadal differentiation in, 5 sarcomas of, 316, 317, 324 Nevi Oral contraceptives sarcoma penetration into, 330 on cervix, 138 abnormal endometrial maturation from, 262- thickness of, 213 on vulva, 28-29, 35-36, 50 263 tissue processing of, 776 Nevus vasculosis, see Strawberry hemangioma cervical lesions from, 133-135, 150 tubal extension into, 342 Newborn endocervical proliferation from, 121 Myosalpinx, 342 genital herpes in, 753 tumor induction by, in animals, 810 Myxoma, of vagina, 73 limb damage in, from adhesions, 784-786 Ornithine carbamyltransferase, in prenatal Myxoma peritonei, omental implants in, 780 maturation index in, 768 diagnosis, 716 Myxomatous degeneration, in leiomyomata, 301- respiratory distress syndrome in, prenatal Ornithine-a-ketoacid transaminase deficiency, 303 diagnosis of, 720-724 prenatal diagnosis of, 718 Myxomatous pattern, of endodermal sinus tumors, vaginal smear cytology of, 768 Orotic aciduria, prenatal diagnosis of, 718 539, 540, 541 Noduloinvasive carcinoma, of cervix, 179, 187 Orotidylic pyrophosphorylase and decarboxylase, in Novak curette, 247 prenatal diagnosis, 718 Norethandrolone, animal tumor induction by, Osteogenic sarcoma, of uterus, 323, 335 Nabothian cysts 811 Osteoid formation, in mixed Mullerian tumor, of cervix, 94, 108, 114, 115, 776 Norethinodrone, experimental tumor induction 338 endometriosis and, 141 by, in animals, 804, 810 ((Ovarioblastoma sarcomatodes," in goats, 833 NADH Norethynodrel, animal tumor induction by, 804, Ovarian arteries, 213, 342, 366 in endometrial epithelium, 239, 240 810 Ovarian cords, 4 in ovarian luteinized tumors, 500 Nuck's canal, cysts of, 28 Ovarian fossa, 365 NADPH, in endometrial epithelium, 240 Nuclear palisading, in leiomyomata, 301, 302 Ovarian fragmentation, animal tumor induction Nausea Nucleocytoplasmic ratio, in cervical intraepithelial by, 810 from endometriosis, 406 neoplasia, 148 Ovarian hormones, role in ovarian neoplasms, 588 from myoma red degeneration, 304 Nucleoli, of endometrial cancer cells, 286, 287 "Ovarian hydrocephalus," 601, 603 from ovarian tumors, 587 Nucleopyknosis, in epithelial cells, 749 Ovarian seminomas, see Dysgerminomas Navicular cells Nylghaie, genital tract tumors in, 827 Ovarian vein, 368

883 Index

Ovary( ian) survival rates, 482, 488 premature failure of, 741-742 abscesses, 352, 387, 388-391 endometriosis of, 404, 409, 475, 779 during reproductive period, 384-385 accessory, 366 infertility from, 740-741 sarcoidosis of, 391 actinomycosis of, 390, 391 pathologic alterations, 409-413 sarcomas of, 497 adenacanthoma of, 479, 481, 482 enzyme activiry in, 372 sarcomatoid tumors of, 506, 5 22 adenocarcinomas of, 454, 495, 496, 499, 507 epithelia! tumors of, 45 3-504 schistosomiasis of, 391-392 adenofibromas of, 454, 455, 467-469 in children and adolescents, 588, 606-611 sclerosing stromal tumor of, 514, 516 malignant, 467-469 histologic classifi<;ation, 454-45 5 serous tumors of, 454, 455-469, 606 adenomatoid tumors of, 497-498, 501 list of, 454 in children and adolescents, 607-610 adenomyomas of, 307 feminizing tumors of, endometrial cancer with, Sertoli-Leydig cell tumors of, 506, 517-523 adhesions of, 779 276 sex cord-stromal tumors of, 505-526 infertility from, 739 fibromas of, 506, 513-514 in children and adolescents, 611-616 age alterations in, 383-385, 779 germ cell tumors of, 527-585 germ cell tumors mixed with, 528 anatomy of, 365-386 gonadoblastomas of, 507, 508, 528 in Stein-Leventhal syndrome, 399, 401 in animals, 798 granulosa cell tumors of, 506-511 stromal cells of, 374, 3 75 arteries of, 366, 383 in children and adolescents, 611-612 hyperplasia, 515 asymmetry of, 36 5 granulosa-stromal cell tumors of, 506-516 struma ovarii, of 528, 552 blood supply of, 366-368 gross examination of, 779 supernumerary, 366 Brenner tumors of, 454, 469, 485-489, 501 gynandroblastomas of, 506, 5 23 surface epithelium of, 368-371 benign, 485-489 hilus of, 371-372 metaplasia, 368-3 71 malignant, 493-494 hilus cell tumor of, 506, 513, 520 teratomas of, 496, 528, 548, 552-568 proliferating, 489-492 histology and histochemistry of, 368-383 thecomas of, 506, 511-513 carcinoids of, 507, 508, 522, 528, 552, 564-566, hormonal influence of, 208 transplantation of, in experimental tumor 632 , 10 studies, 802 carcinoma of, 244, 296 infarction of tubal epithelium on, 355 metastases, 202, 297 from abortion, 251 tuberculosis of, 389 carcinosarcoma of, 494-495 in children and adolescents, 623 tuboovarian abscess of, 349 choriocarcinoma of, 528, 533, 534, 550-552, 707 infertiliry from diseases of, 739-742 as tumor model, 798-805 clear cell adenocarcinoma of, 195, 414, 415 inflammatory diseases of, 387-392 tumors of, 300, 355, 453-637 clear cell carcinoma of, 296, 454, 468, 482-488, intrasplenic grafting of, in experimental tumor animal models, 797-808, 833-856 500 induction, 802-803 in children and adolescents, 586-626 survival rates, 488 Leydig cell tumor of, 506, 513 estrogen-producing, 266, 278 cortex of, 371-373, 375, 377 luteinized stromal cell tumors of, 499-501 gross examination, 779-781 of, 281, 454, 456, 458, lymphatic supply of, 368, 369 malignant, 45 3-63 7 459, 461-463, 471, 499 massive edema of, in children and adolescents, metastases, 83, 359 mucinous, 473-475, 489, 779 621-623 in Turner's syndrome, 433 serous, 478, 479, 485, 779, 780 medulla of, 371-372, 375 vasoligation of, tumor induction by, 802 cystadenofibroma of, 454, 455, 463-468 metastatic cancer of, 290, 339, 361, 627-637 veins of, 366, 368 microscopy, 467 in animals, 807 Oviduct, see Fallopian tube cystadenomas of, 454-461, 488 from breast, 632, 634, 635 Oviductal fluid, composition of, 345 microscopy, 467 from endometrium, 627-629 Ovotestis, in true hermaphroditism, 429, 430 mucinous, 469-472, 500 from GI tract, 629-632, 635 Ovulation, 207, 212 borderline, 472-473 hormonal activiry, 637 cervical mucus changes in, 109 serous, 455-461, 507, 529, 766 pathways of spread to, 632-636 ciliated-cell function in, 344 cysts, 369, 371 mixed epithelial and mesenchymal tumors of, corpus lureum development after, 378 carcinoma in, 414, 415 494 endometrial giant mitochondria in, 230 gross examination, 779 mixed mesodermal tumors of, 495-497 in follicular cyst syndrome, 620 nonneoplastic, 393-403 mucinous tumors of, 454, 469-475, 568, 606, hormonal factors in, 209 dysgenesis, 10 779 indicators of, 739 dysgerminomas of, 528-538 in children and adolescents, 607, 611-613 lack of, causes of, 737 ectopic pregnancy in, 648, 653-655 nerves of, 368 in menstrual cycle, 215 ectopic tissue of, 365-366 in newborn, 383 in perimenopausal period, 225 embryology of, 3 papillary serous carcinoma of, 192 Ovulatory smear pattern, cytology of, 768 embryonal carcinoma of, 528, 534, 544, 546- pinworm infections of, 391 Ovum 548 polycystic, 384, 398-402 "blighted," spontaneous abortion and, 692, 702 endodermal sinus tumor of, 528, 534, 538-546 endocrine abnormalities with, 401-402 in ectopic pregnancy, 648-649 endometrioid carcinoma of, 414-415, 477-482 infertiliry from, 739-740 fertilization and implantation of, 638-645, 735 endometrioid tumors of, 454, 475-483, 485, polyembryomas of, 528, 547-550 fertilized, tubal transport of, 735 499, 500, 522 in postmenopausal period, 385 formation by meiosis, 424

884 Index

pickup by fimbria ovarica, 344 in squamous metaplasia, 751 Penrose phosphate pathway, in endometrial tubal transport of, 341 Parabiosis, in experimental animal tumor epithelium, 240 ciliated cells in, 344 production, 801, 803 Perforation, of ectopic pregnancy, 650, 651 "Owl eye," from cytomegalovirus inclusion, 755 Paracervical ligaments, 103 Pericytes, in hemangiopericytomas, 310, 312 Oxidative enzymes Paradidymis, 6, 7 Perigolgian vesicles, in endocervical cells, 109 in I uteinized ovarian tumors, 500 Parakeratosis, of cervix, 125, 127 Perineum, 14 in ovarian cells, 372 Paralutein cells, 380, 382 lacerations of, 16 Oxytocin, labor stimulation by, amniotic fluid uParamesonephric celomic" tumors, of ovary, Periodic acid-Schiff stain embolism from, 662 453-504 for fungi, 256 , see Mullerian duct for mucin, 281 Parametral lymph nodes, metastatic cancer of, 291 Perioophoritis, 388 Paget cell, histopathology of, 45-46 , inflammation of, 249, 251 Peritoneal lined cysts, 28 Paget's disease, of vulva, 43, 44-46, 51, 53 Parasites Peritoneum, ectopic ovarian tissue in, 365 "Pagetoid" cells, 46 cervical infections by, 129 Peritonitis Pain vaginal infections from, 70 from criminal abortion, 695 abdominal Parasitic leiomyomata, 300 from ovarian tumor rupture, 606 from leiomyomata, 300, 305 Paraurethral gland, see Skene's glands from ruptured cystic teratoma, 560 from endometrial stromal sarcoma, 328 Pariry, mixed Mullerian tumors and, 330 Perivascular pattern, of endodermal sinus tumors, from ovarian infarction, 623 Paroophoron, 7, 8 540, 542 from ovarian tumors, 529, 557 Parovarian cyst, 393, 779 Persian cats, genital tract tumors in, 824, 825, 845 from uterine , 323 ectopy pregnancy and, 648 Pessaries, cervical infections from, 124 from ectopic pregnancy, 648 tubal intussusception by, 354 Peutz-Jeghers syndrome, sex cord tumor with, Pampiniform plexus, of ovarian veins, 366 Partridge, ovarian tumor in, 838-839 524-525, 574, 588 Pancreas, metastasizing carcinoma of, 202, 627, Parvilocular cystoma, of ovary, 468-469, 48 3 Pflugerome, 575-579 636 Passeriformes, genital tract tumors in, 838 Phallus, 9 Pancreatic tissue, in tubal teratoma, 358 Pavement-shaped cells, in clear cell carcinomas, Pheasant, ovarian tumor in, 838 Paneth cells 485 Phosphatidylcholine, role in respiratory distress in cervical mucinous carcinoma, 192 Pearl formation syndrome, 720 in ovarian mucinous tumors, 469, 568 in adenosquamous endometrial carcinoma, 292 Phosphogluconate pathway, in endometrial Papanicolaou test(s), 128, 747 in carcinoma, 48, 51 epithelium, 240 of cervical neoplasias, 162, 169, 177 in dystrophies, 40 6- Phosphogluconic acid dehydrogenase in for endometrial carcinoma, 279 in endometrial adenocanthoma, 292 luteinized ovarian tumors, 500 for gynecologic smears, 745, 746 Peg cells Phosphohexose isomerase deficiency, prenatal in herpesvirus infection, 128 in clear cell carcinomas, 483 diagnosis of, 718 Papillary adenocarcinoma, of cervix, 190, 192, 193, in ovary, 368, 834 Phosphorylase, in cervical parabasal cells, 104 195-196 Pelican, ovarian tumors in, 838 Phthirus pubis, vulvar infections by, 24, 25 Papillary adenomas, ovarian, in animals, 805 Pelvic endometriosis, 404-419 Phytanic acid, in prenatal diagnosis, 718 Papillary adenosquamous endometrial carcinoma, Pelvic lymph nodes, metastatic cancer in, 291 Pick's tubular adenoma, 358 295 Pelvic pain and discomfort of ovary, 506 Papillary carcinoma from endometrial disease, 249 "Picket cells" of columnar epithelial cells, 108, of cervix, 179, 180 from endometrial stromal sarcoma, 328 109 of ovary, 610 from leiomyomata, 300 ((Picket fence" arrangement, of columnar cells, within struma ovarii, 563 from tubal adenocarcinoma, 359 746 Papillary endometrial adenocarcinomas, 281 from tuberculous oophoritis, 389 Piebaldism, 35 Papillary hidradenoma, of vulva, 31 from tuberculous salpingitis, 351 Pigmentation disorders, of vulva, 34-36 Papillary serous cystadenoma, of ovary, 456-459 Pelvic vein, intravenous leiomyomatosis of, 307 ((Pilar" granuloma, in cystic teratoma, 606 Papilloma(s) Pelvis Pineal glands, endodermal sinus tumors of, 538 of cervix, 131, 138-139 ~(frozen" Pink cell anaplasia, 265, 274 of fallopian tube, 356 from endometrial stromal sarcoma, 328 Pinworm of ovary, 454 from endometriosis, 417 salpingitis from, 3 52 in animals, 837, 846-848, 853 tuberculosis of, 256 vulvovaginitis from, 24 Papovavirus, condylomata acuminata from, 16, 17 Pemphigus, benign, of vulva, 25, 26 Pituitary gland Parabasal cells Pemphigus vegitans, 26 gonadotropic tumor of, experimental in atrophic vaginal smear, 769 Pemphigus vulgaris, 26 transplantation of in animals, 803 of cervical epithelium, 104 of cervix, 131 role in menstrual cycle, 208, 211 in cytohormonal studies, 767, 770 Penis, 9, 10, 798 in tumor induction in animals, 804 cytolysis of, 750, 769 in congenital male pseudohermaphrodite, 447 Pituitary growth hormone, uterine tumor cytology of, 745 epidermoid cancer of, in animals, 823 induction in animals by, 810 arypias, 748 herpetic lesions of, in animals, 816 Pituitary hormones, role in ovarian neoplasms, 588

885 Index

Placenta(!) Pleura Posterior fornix aspiration, technique of, 770 abnormalities of, 663-664, 786 endometriosis of, 404, 405 "Postirradiation dysplasia" (PRD), of cervix, accreta, 646-647, 664, 674-675 metastatic cancer of, 339 199-200 in animals, tumors of, 839 Plexiform tumorlets, of myometrium, 319 Postmenopausal period arterial supply of, 674 Plicae cervical endometrial cells in smears of, ~(atherosis" in uteroplacental vasculature of, of fallopian tube, 342-343 abnormality, 764 687-688 in hydrosalpinx, 350 cervical papillary adenofibroma, 140 bacterial infections of, 669-671 Plicae palmatae, 102 cervical squamous epithelium in, 107, 108, 113 barrier, 67 3 Pneumoroentgenography, of polycystic ovaries, endometriosis in, 417 battledore type, 655 401 granulosa cell tumors in, 506-507, 511 bed biopsy studies of tissue under, 674 Podophyllin, condylomata treated by, verrucous mixed mesodermal tumors in, 554 choriocarcinoma in, 709, 786 carcinoma and, 139 ovary in, 371, 372, 385, 779 "choriohemangioma" of, in cow, 830 Pointer, ovarian tumor in, 853 vaginal smear cytology in, 768-769, 770 cotyledons of, 642, 786 Polar bodies, in oogenesis, 424 Postpartum period, microglandular endocervical damage to, from occluded arteries, 688-689 Polycystic ovaries, 384, 398-482 hyperplasia in, 133 degeneration in utero, 694 infertility from, 739-740 Poxviruses, herpesviruses as, 127 endodermal sinuses of, 542 vaginal smear cytology of, 770 Preeclampsia, see Toxemia of pregnancy in erythroblastosis fetalis, 668, 786 Polycythemia, with Leydig (hilus) cell tumor, 615 Pregnancy feral surface of, 786 Polyembryomas, 528 abnormal, fetal growth retardation in, 684-689 fibrin deposition in, 643 behavior and prognosis of, 549-550 absence in, of endocervical eversion, 113 focal choriocarcinoma in, 708-709 histogenesis of, 548 adenomyosis in, 314-315 gross examination of, 782-789 incidence of, 548-549 Arias-Stella reaction in, 141 indications for, 782-783 macroscopic and microscopic appearance of, 549 cellular leiomyomata in, 307, 308 hemorrhage in, 643 mixed tumors of, 547, 554, 568 cervical carcinoma in, 187-188 increta and percreta, 647, 650 therapy of, 550 cervical, choriocarcinoma and, 201 invasive mole and, 704 Polyethylene glycol, genital tract tumor induction cervical decidual polyps in, 13 3 infarcts of, 643, 664-667, 684, 786 by, in animals, 815 cervical epithelium in, 104 abortion and, 692 Polyhydramnios, 656 cervical neoplasia and, 150 information sheet for, 783 chorangioma and, 668 cervical neoplasia in, treatment, 160, 161 in maternal disease, 786 Polymenorrhea, endometrial biopsy for, 246 cervical transformation zone in, 119-120 maternal and fetal circulation in, 643, 786 Polymorphonuclear leukocytes cervical papillomas of, 138 maternal surface of, 787 in endometrial carcinoma, 283 cervix changes in, 120-122 meconium stains on, 786 in endometrial stroma, 221, 223 choriocarcinoma in, 705 membranes, abnormalities of, 6 55 in endometritis, 251 coiled ovarian arteries in, 366 membranacea, 646, 664 in inflammatory disorders, cytology of, 750, 751 condylomata acuminata in, 18, 138 neoplasms of, 668 after radiotherapy, 762 corpus luteum of, 382-383 polyps from, 254, 255 Polypoid carcinoma, of cervix, 179, 180, 187 cytolysis of intermediate cells in, 750 premature separation of, 667, 668 Polpys decidual response in endometrial cyst stroma in, previa, 646, 663, 664 adenomatous, in animals, 827 413 report form for, 784 dilatation and curettage for, 247 dysgerminomas in, 529, 537 saline abortion effects on, 697 endocervical, 125, 131-132 dystocia in, from cervical leiomyomas, 136, 13 7 sectioning of, 787 differential diagnosis, 131 ectopic, see Ectopic pregnancy sizes and weights of, 642, 643, 786 endometrial, 246, 257-262, 280, 776 epulis tumor of, 29 fetal weight compared to, 643 abortions from, 692 in fallopian tube, 341 specimen processing of, 773 in animals, 827 granuloma gravidarum of, 138 succenturiate lobes of, 663, 786 infected, 251 immunologic aspects of, 642, 689, 698 thrombi in, 643 leiomyomata and, 301 leiomatosis peritonatis disseminata in, 358 tissue, retained, endometritis from, 251-253 tissue examination, 773 leiomyomata in, 300 tumor induction in, in animals, 812 of fallopian tube, 356 red degeneration, 304 in twinning, 788-791 fibroepithelial, of vagina, 70, 73 maternal vasculature in, 673 uterine site of, involution postpartum, 645 placental, 254, 255 abnormal, 684-689 vascular supply of, 643, 673, 786 Polyvesicular vitelline tumor pattern, of early, 675-677 thrombi in, 684, 685, 786 endodermal sinus tumors, 542-543 late, 677-684 staining technique, 795-796 Pony, ovarian tumors in, 840, 841 normal, 67 4-677 Placental lactogen, secretion by Porcupines, genital tract tumors in, 827 maturation index in, 768 syncytiotrophoblast, 639 Portio epithelium microglandular endocervical hyperplasia from Placentation, mechanism of, 638-645 of cervix, 104, 105, 107 use of, 133 Placentitis, symptoms and etiology of, 669-671 types of, in endocervical eversion, 112-113 molar (see also Hydatidiform mole) Plasma cells, in endometritis, 252 Portio vaginalis, see Exocervix complications, 704

886 Index

ovarian choriocarcinoma with, 550 Prolactin, in experimental induction of animal for cervical lesions, 160, 161, 168 ovarian teratomas in, 557-559 ovarian tumors, 803 fixation and sectioning, 169 "prolonged," 689 Proprionic acid, in prenatal diagnosis, 716 of cervical malignancies, 171, 173, 175, 178, serous cystadenomas in, 5 29 Proprionyl CoA carboxylase, in prenatal diagnosis, 187 Stein-Leventhal syndrome and, 401 716 Pyelonephritis, from cervical carcinoma, 187 theca Iutein cysts in, 397 Prosoplasia, 168 Pyknosis, of epithelial cell nuclei, 749, 761 tubal endometriosis in, 3 54 of endocervical epithelium, 115-121 Pyknotic nucleus, of superficial cell, 745 tubal stromal cells in, 342 squamous, of cervical polyps, 131 Pyogenic granuloma, of vulva, 29-30 ultrasonography of, 703 Prostaglandins ( PG) Pyometra vaginal smear cytology of, 769 effect on in animals, 809, 810, 812, 842, 846, 848, 849, Pregnandiol, in polycystic ovarian syndrome, 401 myometrium, 299 851 Pregnenolone, 207 tubal contraction, 344 from endometrial carcinoma, 280 in menstrual cycle, 208 in hormone receptor action, 241-242 from endometritis, 254 Premature births, chorangioma and, 668 Prostate, 10 Pyoovarium, in animals, 804 Prepuce, of clitoris, 13, 14 Psammoma bodies Pyosalpinx, 351, 353, 354, 356 Presacral lymph node, tubal drainage to, 342 in cervical papillary carcinoma, 192 from tuboovarian abscess, 349 Presymphaseal plexus, 15 in chronic salpingitis, 344 Pyruvate, in oviductal fluid, 345 Primate animals, genital tract tumors in, 825-826, in endometrial papillary carcinoma, 281, 284 Pyruvate decarboxylase deficiency, prenatal 834 in ovarian neoplasms, 456, 457, 463, 464, 467, diagnosis of, 718 Primigravida, cervical transformation zone in, 121 477, 573, 766 Pyruvate kinase, in endometrial epithelium, 238 Primordial germ cells, 4 Pseudodecidua migration of, 2 gestational origin of, 1 endometriosis and, 141 Quarter horse, ovarian tumor in, 839 Progesterone malignant lymphomas and, 201 Q bands, of chromosomes, 421 in bovine ovarian tumor, 841 Pseudodecidual reaction Queyrat's erythroplasia, of vulva, 41 cytological effects of, 767 cervical carcinoma and, 185 effects on from oral contraceptives, 133 cervix, in pregnancy, 120 Pseudoepi theliomatous hyperplasia, cervical cancer Rabbit endometrial enzymes, 240, 241 and, 185 cervical cytology of, 809 endometrium, 213, 217 Pseudohermaphroditism, 10, 421 female reproductive tract in, 798, 799 ovarian endometrioma, 477 dysgerminomas with, 537 genital tract tumors in vaginal mucosa, 62 female, 447-449 induced, 810, 811, 812 in endometrial carcinoma therapy, 276 male, 444-447, 571 spontaneous, 807, 823, 830-833 experimental animal tumor induction by, 804, Pseudomonas, in puerperal endometritis, 250 Radial arteries, in placenta, 67 4 805, 810, 812 Pseudomyxoma peritonei, 471, 472, 474-475 Radiation therapy from granulosa cell tumors, 507 "Pseudopolyp," of cervix, 94, 98 of adenosquamous endometrial carcinoma, 294 inadequate secretion of, in infertility, 739 Pseudoprecocity, from granulosa cell tumors, 506 for cervical carcinoma, 172, 175, 186, 187, 188, increased responsiveness to, after oral Pseudosarcomatous botryoid polyps, of cervix and 189, 195 contraceptives, 262-263 vagina, 132, 134 cytological changes produced by, 762 for lung metastatic cancer therapy, 292 Pseudosarcomatous pattern, from Delalutin, 263 of dysgerminomas, 536-5 3 7 lutein cell synthesis of, 378 Pseudotubercles, in cervical schistomiasis, 129 of endometrial carcinoma, 290, 291 in menstrual cycle, 207-210 Pseudotumors, of cervix, 131-135 endometrial carcinoma following sterilization prenatal therapy with, virilization from, 448 Pseudovaginal perineoscrotal hypospadi us, by, 276 secretion by symptoms and genetic etiology of, 446- of granulosa cell tumors, 511 ovarian cysts, 394, 397 447 for leiomyosarcomas, 328 syncytiotrophoblast, 639 Psittaciformes, genital tract tumors in, 828, 838 leiomyosarcoma incidence and, 324 testosterone from, in gonadoblastomas, 574-575 Psoriasis, of vulva, 25, 26 for mixed MUllerian tumors, 339 Progestins, 206, 207 Pterygium coli, in Turner's syndrome, 433 mixed MUllerian tumor incidence and, 330 adrenogenital syndrome and, 10 Pubic lice, infections by, 24, 25 of ovarian cystadenocarcinomas, 463 decidual response to, in endometrial cyst Pudendal arteries, 15 of uterine malignant lymphoma, 340 stroma, 413 Puerperal endometritis, 250-253 Radical vulvectomy, 53-55 effects on Puerperal infections, cervicitis and, 124 Radioautography, of cervical dysplasia cells, 145 endometrium, 263 Puerperium Radiography, of vulvectomy specimens, 54 vaginal smear, 769 cervix in, 120-122 Radium, insertion of, for cervical carcinoma, 175 in endometriosis therapy, 741 teratoma rupture during, 558 Randall curette, 247 experimental tumor induction by, in animals, Pulmonary disease, cervicovaginitis emphysematosa Rat 804 with, 130 cervical cytology of, 808, 809 micrograndular endocervical hyperplasia from Punch biopsies female reproductive tract in, 798, 799 use of, 133 for cervical intraepithelial neoplasia, 144-145 genital tract tumors in

887 Index

Rat, genital tract tumors in [cont.] of cervix, 201 for mixed MUllerian tumors, 339 induced, 800-805, 809-812 in children and adolescents, 616, 617 Salpingo-oophoritis, in Crohn's disease, 352 spontaneous, 800, 805, 809, 812-813, 826- in mixed mesodermal tumors, 5 54 Samson's implantation theory, of cervical 827, 835 of uterus, 323, 335, 336, 339 endometriosis, 141 Rauscher leukemia virus, animal tumors from, 812 of vulva, 51 Sandhoff's disease, prenatal detection of, 715 Rectal arteries, 61 Ribbonlike pattern, of struma ovarii and carcinoid Sanfilippo syndrome, prenatal diagnosis of, 718 Rectosigmoid area, endometriosis in, 416 mixed tumor, 566, 567 Sarcoidosis, 128 Rectovaginal fistula, from cervical cancer, 186 Ribosomes, in cancer cells, 286 of fallopian tube, 352 Rectovaginal septum, 781 RNA of genital tract, 391 adenomyomas of, 307 in endometrial epithelium, 239, 240 Sarcoma botyroides, 51, 76 ectopic endometriosis of, 404, 406, 417 estrogen stimulation of synthesis of, 209-210 of cervix, 201 Rectum increased synthesis of, in damaged epithelium, differential diagnosis of, 132 adenocarcinoma of, 46 125 histopathology of, 80, 82-83 bleeding from, in endometriosis, 417 in ovarian cells, 369 of vagina, 79-83 carcinoma of, metastases, 202 Rodents, ovarian tumors in, spontaneous, 805 "Sarcoma ovarii mucocellulare," 631 cystic teratoma rupture into, 560 Rokitansky-KUster-Hauser syndrome, 11 Sarcomas duplication of, 16 genetic etiology of, 449 in animals endometriosis of, 405 Rokitansky's protuberance, 558, 601 induced, 8ll, 814 malignant tumors of, metastases, 83 Round ligament, 7, 8 spontaneous, 826, 833, 835, 838, 842 metastatic cancer of, 75, 172, 179, 186, 187, adenomyomas of, 307 of cervix, 131, 134, 137, 139, 140, 182, 201- 289, 781 RPR test, for syphilis, 20-21 202, 323, 778 pain in Rubella in children and adolescents, 616-617 from cervical carcinoma, 178 abortion and, 692 of fallopian tube, 361 from endometriosis, 406 placental lesions from, 671 of uterus, 305, 322-340, 776, 778 Rectus muscle, adenomyomas of, 307 Rudimentary horn, of uterus, abortion from, 73 7 of vagina, 79-83 Red degeneration, of leiomyomata, 302-305 Rupture, of cystic teratoma, 558 of vulva, 51 Refsum's disease, prenatal diagnosis of, 718 Sarcomatoid patterns, in granulosa cell tumors, Registry of Tumors in the Lower Animals 509 (RTLA), 823 Saboraud's media, for fungi culture, 790 Sarcomatoid tumors, of ovary, 506, 522 Reinke crystalloids Sacral lymph nodes, 103 Sarcomatous change, in leiomyomata, 302 in hilus cell nests, 358, 375, 376, 520, 521 Sacrococcygeal region, endodermal sinus tumors Scabies, of vulva, 24 in gonadoblastomas, 572 of, 538 Scanning electron microscopy (SEM) in stromal-Leydig cell tumor, 513, 517, 519 Saline abortion technique, 696-697, 712 of adenomatous hyperplasia, 270 Renal vein, 368 Salivary glands of endometrial carcinoma, 286-289 Repair, atypia of, of cervix, 125, 126 carcinosarcomas of, in animals, 8ll of endometrium, 234-238 Reproductive tract (female), in various species, mucoepidermoid carcinoma of, 196 of ovarian surface, 371 799 Salmonella infection, in cystic teratoma, 560 of vasculature in pregnancy, 673, 677, 679 Reserve cell carcinoma, of cervix, 190 Salpingitis, 249, 347-350 Scheie's syndrome, prenatal diagnosis of, 718 Reserve cells actinomycotic, 352 Schiller's spray carcinoma, of cervix, 178 subcolumnar, of cervix, llO, ll6-ll7 acute, 34 7-348 Schiller stain, of vaginal and cervical hyperplasia of, in pregnancy, 120-121 adenocarcinoma and, 359 abnormalities, 95, 168 Respiratory distress syndrome (RDS), prenatal chronic, 348-349, 356, 779 Schiller-Duval bodies, 542, 544 studies on, 720-724 follicular, 348 Schistosoma haematobium, 129, 130, 351, 391, 392 Rete testis, 3, 6, 7 gonorrheal, 251, 347 Schistosoma japonicum, 391 Reticulin granulomatous, 350-353, 356, 359 Schistosoma mansoni, 129, 351, 391, 392 in sclerosing stromal tumors, 614 hydrosalpinx from, 349-350 Schistosomiasis stain for, in carcinoma, 182 isthrnica nodosa, 353-355 of cervix, 129, 130, 391 in thecomas, 510 ectopic pregnancy from, 35 3, 648, 738 of endometrium, 2 56 Reticulum, in hemangiopericytomas, 310-312 infertility from, 738 of fallopian tube, 351-352, 391 Reticul urn cell sarcomas leiomyomata and, 300 genital, 70, 128, 391-392 of cervix, 200 from pinworm, 352 of ovary, 391-392 of vagina, 80 from sarcoidosis, 352 Schwann cells Retinal anlage tumor, of ovary, 568 from schistosomiasis, 351-352 cervical blue nevi and, 138 Retrievers, ovarian tumors in, 850, 851 tuberculous, 128, 256, 350-351 of vagina, lesions of, 74 Retroperitoneal masses, leiomyomata and, 300 adenocarcinoma confusion with, 351 Schwannian sheath, of cervix, malignant Rhabdomyoblasts, in mixed MUllerian tumors, Salpingo-oophorectomy melanoma and, 200-201 335-337, 339 for endometrial carcinoma, 291 Schwannoma Rhabdomyoma, of vagina, 73 for endometrial stromal myosis, 330 of vagina, 80 Rhabdomyosarcomas for leiomyosarcomas, 328 of vulva, 30

888 Index

Scirrhous carcinoma, of cervix, 190, 192, 196 Sex chromatin, use in X chromosome Sigmoid mesentery, ectopic ovarian tissue in, 365 Sclerocystic ovaries, 398-402 determination, 427 Signet cells, in Krukenberg rumor, 514, 566, 629 Scletosing hemangiomas, see Histiocytomas Sex chromosomes Sinovaginal bulbs, 6, 8 Sclerosing stromal tumors in congenital malformations, 4 Skene's glands, 13, 14 in children and adolescents, 612, 614, 615 in differerltiation, 4 Skin, endometriosis of, 404, 409 of ovary, 514, 516 disorders of, 421-427 Small intestine, metastatic cancer of, 708 Sclerosis, of chorionic villi, 692, 693 abnormalities from, 429, 713 Smegma Scottish terrier, ovarian tumor in, 853 mosaicism of, 424-425 in animal cancer studies, 823 Scrotal seprum, 9 Sex cord stroma-getm cell tumors, 569-579, 588 in vaginal cancer studies, 813 Scrotal swellings, 9, 10 Sex cord-stromal tumors Specimens Scrotum, angiokeratoma of, 29 of ovary, 505-526 obstetric and gynecological, processing of, Seal, genital tract tumors in, 828, 837 in children and adolescents, 588, 589, 611- 772-796 Searworm, vulvovaginitis from, 24 616 of vulva, processing of, 52-55 Sebaceous glands getm cell tumors mixed with, 528, 545, Sperm in cervical mucosa, 122 569-579, 588 abnormalities of, in inferriliry, 734 of ovary, rumors of, 568 Sex cords, primitive, 2, 3, 5 antibodies to, 735 of vulva, 13 Sex differentiation capacitation of, 735 Seborrheic keratoses, of vulva, 34 in females, 420-452 in cervico-vaginal smear, 748 Secretory cells of mammalian embryos, 1-5 DNA of, in cervical oncogenesis, 152 of fallopian rube, 345 factors influencing, 4-5 endocervix secretions and, 108, 109 of tubal epithelium, 343, 350 Sex hormones transport of, 735 Sedimentation rate, elevated, from pedunculated cells producing, autoantibodies to, 742 tubal transport of, 341, 345 leiomyoma, 305 chronic exposure to, experimental ovatian vaginal lethal factor for, 736 SEM, see Scanning electron microscopy tumor induction by, 804 Spermatogenesis, meiosis in, 423 Seminal vesicles, 10 effects on Sphinctet, isthmus as, 104 Seminomas endometrium, 214-224, 240-241 Sphingomyelin, in prenatal diagnosis, 717 in animals, 833, 836, 846, 851-852, 856 endomettial polyps, 258-259 Spina bifida testicular, 569, 573 in endometrial carcinoma, 279 in aborted feruses, 692, 793 Senile endometritis, 254, 255 in gonadal differentiation, 5 cystica, prenatal detection of, 713 Senile hemangioma, on vulva, 28-29 from granulosa cell tumors, 506, 510 Spindle cell carcinoma, of cervix, 180, 182, 183 Serosa ovarian synthesis of, 372 Spindle cell sarcoma, in animals, 826 of fallopian tube, 342 secretion by, ovarian cysts, 394 Spital arteries cysts in, 346 rypes of, 206 in placenta, 673, 676, 677-679, 684 Serous cystadenocarcinoma, of ovary, 281, 456, Sex-linked disordetS, prenatal diagnosis of, 713 "acute athetosis" in, 687-689 458, 459, 461-463, 499, 766, 779, 780 Sex revetsal, 5 Spital arterioles Serous inclusion cysts, of ovary, 393, 394, 455 Sexual abnormalities in endometrium, 213-214, 221 Serous rumors dysgerminomas with, 537-538 in endometrial hyperplasia, 267, 268 of ovary, 454, 455-461, 489, 606 in humans, 10-11 otal contraceptive effect on, 263 in children and adolescents, 607-610 Sexual contact, hetpesvirus infections from, 127 in placenta, 642 Sertoli cell tumor, in children and adolescents, Sexual intercourse Spleen, metastatic carcinoma of, 708 612, 613 intrautetine sperm srudies following, 736 Spontaneous abortion, chromosome abnormalities Sertoli cell(s) role in cervical neoplasia, 150, 178 and, 691-694 embryology of, 3 as source of genital tuberculosis, 350 Spray carcinoma of Schiller, 178 immature, in gonadoblastomas, 569 vaginal bleeding after, from cervical carcinoma, Squamocolumnar junction in ovarian sex cord-stromal tumors, 505, 506 178 of cervix, 110-114, 168 Sertoli cell tumor Sexual precociry. (See also Isosexual precociry) neoplasia origin in, 158, 163 in animals, 845, 849 from choriocarcinomas, 550 in primigravida, 121 in children and adolescents, 613 from dysgetminomas, 529, 53 7 transformation zone, 119 Sertoli-Leydig cell tumor from follicle cysts, 618, 620 Squamous cell carcinoma in animals, 833, 835, 837, 845 from ovarian tumors, 576, 579, 587 in animals in children and adolescents, 612, 615-616 with teratocarcinoma, 595 induced, 811, 813, 815 of ovary, 506, 517-523 from thecomas, 613 spontaneous, 825, 827 Sertoliform rubules vaginal smear cytology of, 770 Squamous cell carcinoma, 17 in canine ovaries, 854-855 Sheep, genital tract tumors in, 805, 823-824, 833 of cervix, 93, 132, 139, 155, 171-176, 179 in rat ovary, 835 Shock, from torsion of pedunculated leiomyoma, cytological diagnosis, 759-760 Sertoliform tumors, in animals, 833, 842, 846, 305 cytology, 756-75 7 849-851, 855, 856 Sialic acid, of zona pellucida, 377 differential diagnosis, 185, 189, 197 Setetonol, leiomyoma induction by, in animals, Sigmoid colon, endometriosis of, 417 invasive, 177-187 801 Sigmoid flexure, adenomyomas of, 307 microinvasive, 171-176

889 Index

Squamous cell carcinoma, of cervix [cont.} from schistosomiasis, 129 cytology of, 745, 746 precursors of, 143-164, 178 in Stein-Leventhal syndrome, 401 arypias, 748 radiation therapy, 198-199 from tubercular salpingitis, 351 Superficial vulvectomy, 53 types, 180 from tuberculous oophoritis, 389 Supernumerary ovary, 366 warty, 189 17 {:l-Sreroid dehydrogenase, in ovarian cells, 369 Suppressor substance, 10 of endometrium, 294 Steroid hormones, see Sex hormones Supraclavicular lymph nodes, metastatic cervical mixed adenocarcinoma with, 293 Steroid Sa-reductase, decrease of, in male cancer in, 186 in mixed mesodermal tumors, 544, 560, 562, pseudohermaphrodite, 446 Surface implantation, of metastatic ovarian 606 Steroids, nomenclature of, 207 carcinoma, 632 ovarian Brenner tumors and, 493 Stilbestrol Surgery, pelvic, ovarian abscess from, 388 with sarcoma, 323, 336. (See also Mullerian animal rumor induction by, 804, 813 Surgical specimens tumors) endometrial adenocarcinoma and, 272 data sheets for, 772, 773 Squamous carcinoma of vagina, 77, 93 Stratum spinosum, of cervical epithelium, 104 processing of, 772-796 of vulva, 18, 30, 46-49 Strawberry hemangioma, on vulva, 28-29 Suspensory ligament, 7, 365 staging, 47 Streak gonads, 440 Sweat glands, in cervical mucosa, 122 Squamous epithelium in gonadal dysgenesis, 591-592 Swine, genital traer tumors in, 805, 824, 827, 833 benign tumors of, 33-34 hormone production in, 574 Swiss-cheese hyperplasia, 265, 267 of cervix, 104-107 in monosomy X mosaics, 438 Syncytiotrophoblast atypia of repair of, 125, 127 neoplasia of, 442 cells resembling, in dysgerminomas, 533, 535, cytologic arypias of, 748 in Turner's syndrome, 432, 433 537 in teratomas, 599 Streptococci in choriocarcinomas, 551, 553, 705-707 of vagina, 6 5 cervical inflammations by, 124, 125 development of, 638-639 of vaginal mucous membrane, 61 in oophoritis, 387 histology of, 694 Squamous metaplasia in puerperal endometritis, 250 hormones excreted by, 639 of amnion, 656, 658 Streptococcus pyogenes, vulvovaginitis from, 68 "knotting" in, 643, 644 in animals, 809, 825, 827 Stress incontinence, from leiomyomata, 300 in molar pregnancy, 701 cytology of, 749-751 String, carcinogens on, use in tumor induction in polyembryomas, 549 definition of, 750-751 studies, 814, 816 in toxemic placentas, 667 of endocervix, 115-116, 155 Stromal cells (endometrial) Syncytium, 673 of endometrioma, 412 cyclic changes in, 220 Syndactyly, amnionic bands and, 656 in mixed Mullerian tumors, 335 edema of, 250, 251 Syphilis ovarian Brenner tumors and, 493 enzymes of, 240 cervical neoplasia and, 150 Squamous papilloma histology, 229, 232-234 of cervix, 129 of cervix, 138, 139 Stromal edema, from oral contraceptives, 133 of placenta, 669, 786 carcinoma and, 185 Stromal glandular asynchrony, 246 vulvar infections in, 17, 35 of vagina, 72 Stromal nodule, 328 Syringomas, of vulva, 33 of vulva, 34 Stromal sarcoma, of uterus, 323, 328-331, 336 Squamous prosoplasia, 134 Stromal rumors, in animals, 842 cervical, 125 Stromarosis, 328 Tadpole cell, in carcinoma in situ, 758, 759 cervical carcinoma and, 185 Struma ovarii, 528, 552 Talc, as tubal foreign body, 352 of endocervix, 115-120, 135 in children and adolescents, 604, 606 Tampons, cervical infections from, 124 from oral contraceptives, 133 etiology and histology of, 562-563, 566 Tay-Sachs disease, prenatal detection of, 715 of papillary adenofibroma, 139 mixed carcinoid with, 566-568, 571 Teerh, in cystic teratomas, 601, 603 Squirrel, genital tract tumors in, 827, 83 7 Subcolumnar reserve cell carcinoma, of cervix, Teilum rumor, see Endodermal sinus tumor Stains, for cervical lesion diagnosis, 168 180, 196-197 TEM, see Transmission electron microscopy Staphylococci Subovarian lymphatic plexus, 368 Tenesmus, from endometriosis, 406 Bartholin abscess and, 27 Suburethral diverticula, 14 Tenny change, in toxemic placenta, 667 cervical inflammations by, 124, 125 Succenturiate lobes, of placenta, 663 Teratoblastoma, in children and adolescents, 592- Staphylococcus aureus, vulvovaginitis from, 68 Succinic dehydrogenase 593 Staphylococcus pyogenes, placental membrane in endometrial epithelium, 239, 240 Teratocarcinoma( s) infection by, 659, 669 in luteinized ovarian rumors, 501 canine ovarian tumors and, 856 Starch, as tubal foreign body, 352 Suction curettage, 247-248 in children, 595-597 Stein-Leventhal syndrome of hydatidiform mole, 699-700 Teratoid sarcomas, in children and adolescents, endometrial carcinoma and, 276, 401 Suction technique, of abortion, 695 616, 617 endometrial hyperplasia in, 266 Sulfatide, in prenatal diagnosis, 717 Teratologic effects, of drugs, 692 infertility from, 739-740 "Sulfur granules," in actinomycotic infections, Teratomas polycystic ovaries in, 399, 401, 739 129, 130, 257, 352, 391 in animals, 805, 807, 835-839, 842-846, 852- vaginal smear cytology of, 770 Superficial cells 853, 856 Sterility in cervical dysplasia, 75 5 of fallopian tube, 357-358 in males, from mumps, 388 of cervical epithelium, 105, 106 of ovary, 528, 548, 552-568

890 Index

in children and adolescents, 589, 592, 595- Theca cells placental infarcts and, 666, 667, 684 600 antibodies to, ovarian failure and, 742 in rabbits, tumors and, 832 classification, 55 2 in ovarian sex cord-stromal tumors, 505, 506 symptoms of, 668 composition, 604 Theca interna Toxoplasmosis cystic, 489, 528, 555-560, 599-606 blood supply of, 366 abortion and, 692 histiogenesis, 55 7 estrogen synthesis by, 377 of placenta, 671 immature, 528, 551-554, 597-600 in follicular cysts, 394 TPNH, see NADPH malignant, 595-597 I uteinization of, 3 78, 379 Trabecular pattern, in granulosa cell tumors, 509 in mixed tumors, 469, 533, 535, 539, 546, in polycystic ovary, 400, 401 Trachoma inclusion conjunctivitis (TRIC), 547, 554, 560, 568, 573, 574, 606 lymphatics of, 368 cytological diagnosis of, 755 monodermal, 528, 552, 568 in polycystic ovary, 399 Transformation zone solid mature, 528, 554-555 streaks of, in gonal dysgenesis, 431 of cervix, 112-120, 155 struma ovarii, 562-564 Theca lutein cysts, 397-398 in neoplasia, 158 Testes Thecagranulosa tumors, see Granulosa-theca cell Transfusion syndrome, in twinning, 660-661, 786 embryology of, 3-4 tumors Translocation (chromosomal) embryonal carcinoma of, similarity to Thecal reaction, of luteinized ovarian stromal abnormalities from, 441 endodermal sinus tumor, 538 tumors, 499-501 in aborted fetuses, 692 Leydig cell rumors of, 521 Thecomas Transmission electron microscopy (TEM) mumps infection of, 388 in animals, 835, 841 of endometrial adenocarcinoma, 285-286, 289 neoplasms of, 589 in children and adolescents, 612-614 of ovarian cystadenofibroma, 465 ovarian neoplasms compared to, 527, 528, of ovary, 506, 511-513 of ovarian surface, 371 530 Theelol and theelin, animal tumor induction by, tissue processing for, 773 in testicular feminization, 444-445 809 of vasculature of pregnancy, 673, 677, 679 neoplasia in, 443 Thigh, endometriosis of, 405 Transplantation methods, in studies of Testicular feminization syndrome Thin-layer chromatography, of experimental animal tumors, 801-802 description of, 10 lecithin:sphingomyelin ratio, 721 Trauma gonadal dysgenesis and, 442, 443 Thrombi, in late uteroplacental arteries, 684, 685, abortion from, 692 incomplete variant of, 446 786 abruptio placentae and, 667 infertility in, 741 Thrombophlebitis Treponema pallidum, as cause of condyloma lata, in male pseudohermaphrodites, 444-447 from endometritis, 249 17, 19, 21 vaginal smear cytology of, 769-770 migratory, with ovarian neoplasms, 587 TRIC agent, as cause of lymphogranuloma Testicular grafts, animal tumor induction by, 810 "Thrush-like" patches, in vaginal candidiasis, 68 venereum, 17, 22-23 Testicular elements, in ovarian sex cord-stromal Thymectomy, ovarian rumor induction by, in Tricarboxylic acid cycle, in endometrial tumors, 506 experimental animals, 802 epithelium, 240 Testicular hormones, in fetal masculinization, 421 Thyroid gland Trichomonas vagina/is Testicular seminoma, dysgerminoma compared to, carcinoma of as cause of trichomoniasis, 68 527, 528, 530 carcinoid and, 568 cervical infections from, 124-127 uTestis cords," 4, 7 metastases, 202, 632 cervical neoplasia and, 150 in canine ovaries, 856 in mixed rumors, 560, 606 cytological identification of, 752, 753, 754 Testosterone tissue gas formation by, 130 elevated ectopic, in struma ovarii, 562,566, 571 Trichomoniasis Leydig (hilus) cell tumor, 615 in tubal teratoma, 358 cervicovaginitis emphysematosa with, 129-130 from Sertoli-Leydig cell tumor, 616 Thyroid hormone, tumor induction by, in histopathology and diagnosis of, 68, 69 ovarian synthesis of, 372 animals, 804 vaginal, 68 in polycystic ovarian syndrome, 401-402 Thyrotoxicosis, with struma ovarii, 562 Triethylene melamine, ovarian tumor induction production of, from gonadoblastomas, 574-575 Tissue culture, of cervical dysplasia cells, 145 by, in animals, 801 Sertoli-Leydig cell tumors and, 517 Toluidine blue, as stain for cervical neoplasias, 168 Triglycerides, in prenatal diagnosis, 718 tumor induction by, in animals, 804, 805, 810, Tonofilaments Trimethylbenzanthracene (TMBA), ovarian rumor 813 in cervical intraepithelial neoplasia, 148 induction by, in animals, 800-801 Testosterone receptors, lack of, in testicular in cervical squamous carcinoma, 184 Triploidy, in aborted fetuses, 692 feminization syndrome, 445 Torsion Trisomy 21, 421 Tetracycline fluorescence test, for cervical from ovarian cystic teratoma, 558 Tritiated thymidine labeling index, increase in, in neoplasia, 168 from ovarian cysts, 618, 620 cervical neoplasias, 163 Tetraploidy, in aborted fetuses, 692 of ovarian rumors, 529, 533, 576, 587 Trophoblast Thayer-Martin cultures, for detection of of umbilical cord, 655 abnormality of, in molar pregnancy, 702 gonorrheal endometritis, 251 Toxemia of pregnancy cells, in placental arteries, 676-677, 682 Theca cell rumors abruptio placentae and, 667 in choriocarcinoma, 705-707 in animals chorangioma and, 668 gestational disease of, 698-709 induced, 804 hydatidiform mole and, 702-704 in hydatidiform mole, 699-700 spontaneous, 845 immunopathology of, 689 in implantation, 638

891 Index

Trophoblast {cont.] hyperreactio luteinalis in, 702 painful as pulmonary emboli, 640 identical, 660, 788 from cervical infections, 124, 127 similarity to malignancy, 698 intra- and extrauterine, 696 Urogenital groove, 9 ultrastructure and function of, 673 membrane studies of, 788 Urogenital ridge, 8 Trophoblastic disease molar, 695, 702, 703 , 8, 10 following molar pregnancy, 704 monoamnionic, 661, 662 Uroporphyrin, in prenatal diagnosis, 714 theca lutein cysts from, 398 with monosomy X, 433 Urothelial cells, Brenner tumor similarity to, 491, Trophoblastic tumors placenta in, 788-791 607 in animals, 826 theca lutein cysts in, 397 Uterine artery, 61, 103, 213, 342, 366 of fallopian tube, 362 transfusion syndrome in, 660-661, 786 Uterine bleeding. (See also Vaginal bleeding) transplantation to animals, 816 Typhoid fever, as teratoma complication, 560 from abnormal endometrial maturation, 26o- Tropocollagen Tzank's cells, of pemphigus vulgaris, 131 263 in endometrial stromal cells, 233-234 from adenomyosis, 312 in ovarian stromal cells, 3 7 4 biopsy for, 246 Thyroid-stimulating hormone (TSH) Ulceroinvasive carcinoma, of cervix, 179, 187 from corpus luteum cyst, 397 overproduction of, endometrial carcinoma and, Ulcers from endometrial carcinoma, 279 279 cervical, from herpes genitalis, 127 from endometrial diseases, 249 Tubal fluid, 345 in endometritis, 249 from endometrial schistosomiasis, 256 Tubal insuffiation, in infertility studies, 738 of , 25 in endometritis, 254 Tuberculosis in senile endometritis, 254 in estrinism, 399 in aborted fetus specimens, 790 Ultrasonography, of hydatidiform mole, 703 from hemangiopericytomas, 312 of placenta, 669, 670 Umbilical artery, absence of, 655 from leiomyomata, 300 vaginitis from, 68 Umbilical cord from myometrial mesodermal tumots, 316 of vulva, 17, 23, 25 abnormalities of, 655, 788 postmenopausal, endometrial carcinoma in, 275 Tuberculous cervicitis, histopathology of, 128-129 circulatory, congenital anomalies and, 788 from Sertoli-Leydig cell tumors, 517 Tuberculous endometritis, 256 chorangioma of, 668 stimulation by serous inclusion cyst, 397 Tuberculous oophoritis, 389 gross examination of, 788 from teratomas, 5 51 Tuberculous salpingitis, 128, 256 infections of, 659, 670 Uterine canal, 7 Tuboovarian abscess, 347, 349, 360, 388-390 length of, 655 Uterine vein, intravenous leiomyomarosis of, 307 Tuboovarian adhesions, from endometriosis, 409 strangulation by, 793, 794 Uteroovarian ligament, 365 Tubular adenomas, in animals, 806, 856 velamentous insertion of, 655, 656 adenomyomas of, 307 Tumors. (See also Carcinoma and individual Umbilical vein, thrombi in, 786 Uretosactal ligament, 103 rumors) Umbilicus adenomyomas of, 307 in domesticated animals, 823-825, 839-856 adenomyomas of, 307 swelling of, from endometriosis, 406 drug-induced, from alkylaring agents, 763 endometriosis of, 404, 409 Uterus. (See also Cervix, Endometrium, human, laboraboratoty animals as hosts for, 816 metastatic cancer to, 26o Myometrium) in laboratory animals Urea, vaginal lesions induced by, 813 adenomyomas of, 307 induced, 800-805, 809-812 Uremia, from advanced cervical cancer, 187 adenomyosis of, 3 53 spontaneous, 825-827, 834-836 Ureter, 365 adult measurements, 213 malignant, see Malignant tumors compression of, from cervical cancer, 187 in animals, 798 spontaneous, in uterus and ovaries of animals, metastatic carcinoma of, 186 atony of, from adenomyosis, 314-315 822-861 Ureteral lymph node, endometriosis of, 405, 408 bivalve opening of, 776 Tunica albuginea, 3, 5, 369, 371, 588 Urethane, tumor induction by, in animals, 807, bleeding from, see Uterine bleeding lymphatics of, 368 808 carcinoma of, 260 in polycystic ovary, 399 Urethra, 9, 10 congenital abnormalities of, 10-11 Tunica media, of decidual spiral arteries, 677 carcinoma of, 51, 52 congenital absence of, 449 Turner's syndrome metastases, 51 cytology, 770 chromosome abnormalities and, 438, 440 developmental defects of, 16 curettage of, 244-245 congenital origin of, 4 diverticula of, 52 techniques, 247-248 description of, 432 gonorrhea of, 251 development of, 211-212, 808 gonadoblastomas in, 57 5 lesions of, 51-52 duplex type, 798 somatic features of, 434 prolapse of, 51 dysfunctional bleeding of, 245 vaginal smear cytology of, 769 Urethral meatus, 13, 14 ectopic endometrium in, 404 from X-chromosome monosomy, 432-436 Uric acid, in prenatal diagnosis, 717 embryology of, 8 Twinning and twins Urination endometrial stromal sarcoma of, 328-331 abnormalities with, 659-662 frequency enlargement of, in adenomyosis, 312, 313 amniochorionic adhesions with, 784, 785 in endometriosis, 406 estrogen receptors in, 209 cord abnormalities in, 655 from leiomyomata, 300 of feral mammals, 808 fraternal, 661, 788 from mixed MUllerian tumors, 331 gross examination of, 774, 776-778

892 Index

inflammatory diseases of, 249-25 7 placental lesions from, 671 in animals, 809, 812-816 leiomyomas of, see Leiomyomata Vagina benign, 73-74 leiomyosarcomas of, 323-328 adenocarcinoma of, after prenatal DES gross examination, 781 clinical aspects, 323-324 exposure, 192, 813 malignant, 74-93 histology, 324-327 adenosis of, 195 Vaginal artery, 15, 61 occurrence, 323 after prenatal DES exposure, 93-98, 100 Vaginal bleeding. (See also Uterine bleeding) therapy and prognosis, 327-328 anatomy of, 59-63 from cervical carcinoma, 178, 189 lipomas of, 305 animal models for tumors of, 812-816 from cervical endometriosis, 141 lymphatics of, 368 atresia of, 11 from cervical sarcomas, 201 malignant lymphoma of, 323, 339-340 atrophic, 67 from endometrial stromal sarcoma, 328, 330 malignant tumors of, 278-298, 322-340 attachment to uterus, 60 from endometritis, 252, 254 endometritis from, 2 51 bleeding from, see Vaginal bleeding from hydatidiform mole, 702 measurements of, 774 blood supply of, 61, 62 from intravenous leiomyomata, 310 metaplasia in animals, 809 candidiasis of, 68 from mixed Miillerian tumors, 331 mixed mesodermal tumor of, 778 carcinoma of, 74-79, 92, 172, 296 from MUllerian adenosarcoma, 339 mixed MUllerian rumors of, 323, 331-339 after cervical carcinoma, 199 from uterine leiomyosarcomas, 323 MUllerian adenosarcoma of, 339 in infants, 76-79 Vaginal discharge multiparous, 103 choriocarcinoma of, 84, 85, 708 brown, from mixed MUllerian tumors, 330 in neonate, 211-212 clear cell adenocarcinoma of, 195, 296 from diplococcal infections, 124, 125 ovarian anatomy and, 366 congenital abnormalities of, 11, 16 from herpes genitalis, 127 placenta site in, involution of, 645 congenital absence of, 449 serosanguinous polyps of, 246, 251, 257-262, 280, 301, 692, cysts of, 70 with tubal adenocarcinoma, 359 776 desquamative inflammatory vaginitis of, 69 with tubal sarcomas, 361 prolapse of discharge from see Vaginal discharge from tubal prolapse, 354 cells in vaginal smears in, 745 diseases of, 59-86 in tuberculous oophoritis, 389 cervical hyperkeratosis with, 125 dysplasia of, 76 Vaginal plate, 6 vaginal changes from, 70 embryology of, 8, 10, 59 Vaginal smear at puberty, 212 emphysematous vaginitis of, 69, 70 changes in, with age, 768-769 rupture of, from adenomyosis, 314 endodermal sinus tumors of, 538 technique of, 770 sarcomas of, 305, 322-340, 776 endometriosis of, 404-406 use in cytological studies and diagnosis, 744- classification, 322-323 fibroepithelial polyps of, 70, 73 771 gross examination, 778 gonorrhea of, 63, 251 Vaginitis, cytology of, 752 metastases, 202, 328 gross examination of, 781 Vaginitis emphysematosa, see Emphysematous sectioning of specimens of, 776-778 Haemophilm vagina/is infections of, 63, 68 vaginitis septate, 8 inflammatory diseases of, 63-70 Valine, in prenatal diagnosis, 716, 717 simplex rype, 798 infertility from abnormalities of, 736 Valine transaminase, in prenatal diagnosis, 716 smooth muscle of, steroid hormone effects on, invasive mole metastasis to, 705 Varicella, placental lesions from, 671 242 malignant melanoma of, 79 Variola, placental lesions from 671 sperm collection from, 736 menstrual blood clots in, 213 Vasa previa, 655 tumors of, 241-298, 305, 322-340 metastatic cancer of, 83-85, 290, 339 Vascular leiomyomata, 306, 326 in animals, 808-812, 823-833 mucous membrane of, 61-62 of cervix, 137 benign, 257-262, 299-321 histology, 64-67 Vascular polyps, of cervix, 131 gross examination, 774-778 uterine prolapse and, 70 Vascular supply, of normal and abnormal malignant, 278-298, 322-340 nerves of, 61 pregnancy, 673-690 vagina attachment to, 60 papillomas of, 138 abortion and, 692 weights of, 77 4 parasitic infections of, 70 Vasoligation, ovarian, tumor induction by, in Uterus arcuarus, 11 polyps of, 132 experimental animals, 802 Uterus bicomis, 10, 11 prenatal exposure to diethylstilbestrol effects on, VDRL test for syphilis, 20-21 abortion from, 7 3 7 87-101 Veins Uterus didelphys, 10, 11 prolapse of, 70-71 of endometrium, 214 abortion from, 73 7 ridges of, from DES exposure, 93, 98 of ovary, 366, 368 Uterus masculinus, 6 sarcomas of, 79, 323 of vagina, 62 Utriculus prostaticus, 6, 7 schistosomiasis of, 391 Velamentous insertion, of umbilical cord, 655, 656 size of, 59 Venous thrombosis, in red degenerated myoma, squamous cell carcinoma of, 77, 93 305 Vabra suction curettage, 247-248 cytology, 767 Verrucous carcinoma, 17 for endometrial cells, 770 strucrutal relationships of, 60 of cervix, 138, 139, 179, 180, 188-189 Vaccinia trichomoniasis of, 68, 69 of vulva, 48-49, 188 cytological identification of, 753 tumors of, 73-93 Vesical arteries, 61

893 Index

Vesicovaginal fistula, from cervical carcinoma, 186 condyloma acuminatum of, 16~18 Wilder's reticulum stain, for smooth muscle Vestibule, 14 condyloma lata of, 17, 19 tissue, 309 mucous cyst of, 27, 28 cysts of, 26~28 Wolffian adenoma, in fallopian tube, 358 Vestigial structures, of cervix, 121~122 development defects of, 16 Wolffian ducts, 3~6, 8, 10 Vibrio fetus, maternal infections of, abortion from, duplication of, 16 cysts, 28, 70 692 dystrophic conditions of, 36~37 of fallopian tube, 345~348 Villi (chorionic), 641~643 endometriosis of, 404, 405, 409 defects of development of, 449 abnormalities of, in abortion, 692~694 epidermoid carcinoma of, 74~ 79 endometriosis and, 405 in ectopic pregnancy, 651~652 cytology, 767 vestigial "ghost," 694 fungal infections of, 23~24 in cervix, 121~122 histology of, 644 granuloma inguinale of, 17, 22, 23 in ovary, 368, 375 hydropic, 692, 693 gross examination of, 781~782 Wolman's disease, prenatal diagnosis of, 718 in invasive mole, 705 herpetic infection of, 17, 18~ 19 in molar pregnancy, 699~ 701 hyperpigmented lesions of, 35~36 in placental insufficiency, 689, 692 hypopigmentation of, 34~35 X chromosome scleroti, 692, 693 infectious diseases of, 16~24 banding identification of, 421 Vinegar eels, in cervico-vaginal smears, 75 5 inflammatory diseases of, 24~26 isochromosomes of, 427~429, 440 Vinyl copolymer, tumor induction by, in animals, intraepi thelia! neoplasia of, 41 ~46 in Lyon hypothesis of cervical neoplasia, 15 7 811 invasive mole metastasis to, 705 "Lyonization" of, 443 "Violin string" adhesions, in chronic salpingitis, lymphatic system of, 15 monosomy of, 429 349 lymphogranuloma venereum of, 17, 22~23 mosaicism with, 436~438 Viral transformation, cell surface changes from, melanoma of, 49~ 50 in Turner's syndrome, 432~436 285 metastases to, 51 mosaicism of, 429 Virilization molluscum contagiosum of, 17, 21 poly-X females and, 429 in congenital adrenal hyperplasia, 448 nerves of, 15~16 in sex differentiation, 4 from dysgerminomas, 53 7, 5 38 papillomas of, 138 structural aberrations of, 438~440 with gonadoblastomas, 570, 574 parasitic infections of, 24 X rays, animal tumor induction by, 800, 811 from granulosa cell tumors, 507, 611 pigmentation disorders of, 34~36 45X karyotype, abnormalities from 432~436 in heifer with ovarian tumor, 841 premalignancies of, 41 Xeroderma pigmentosum, prenatal diagnosis of, from Krukenberg tumor, 63 7 sarcomas of, 51 718 from Leydig (hilus) cell tumors, 615 schistosomiasis of, 391 Xerography, of vulvectomy specimens, 54, 781~ in polycystic ovarian syndrome, 399, 401, 402 specimens of, processing, 52~55 782 from prenatal hormone treatment, 448 squamous carcinoma of, 46~49 from Sertoli-Leydig cell tumors, 517, 521, 616 syphilitic chancre of, 17, 19~21 Viruses and viral infections topography of, 14 animal tumor induction by, 811~812, 815 tuberculosis of, 17, 23 Y chromosome, 431 placental effects of, 671 tumors of banding identification of, 421 ~422 vaginitis from, 68 in animals, 809, 812 in sex differentiation, 4 Vitamin B12 coenzyme, in prenatal diagnosis, 717 benign, 28~36 teratocarcinoma in female with, 595 Vitamin B12 deficiency, cytological effects of, gross examination, 781~782 Yak, genital tract tumors in, 827 762~763 malignant, 31, 32, 46~51 Yolk sac, primordial germ cell origin in wall of, Vitelline carcinoma, see Endodermal sinus tumor Vulvectomy techniques, 52~ 55 1~2 Vitiligo, of vulva, 35 Yolk sac tumor, see Endodermal sinus tumor Vomiting from endometriosis, 406 Walthard rests from myoma red degeneration, 304, 305 Brenner tumors and, 488, 489 Zebu cow, ovarian tumor in, 842~845, 856 from ovarian tumors, 587 in fallopian tube, 346 Zenker's solution, 54 von Recklinghausen's disease, neurofibromata Watered silk pattern, in granulosa cell tumors, Ziehl-Neelsen technique, for M. tuberculosis with, 31 508, 509 identification, 128 Vulva, 13~58 Wedge resection, of ovary, for Stein-Leventhal Zinc, teratomas from, 558 adenocarcinoma of, 51 syndrome, 401, 402, 739~ 740 Zollinger-Ellison syndrome, from ovarian anatomy of, 13~16 Weight loss, from cervical carcinoma, 178 neoplasms, 587 animal models for tumors of, 812~816 Whale, genital tract tumors in, 828, 837 Zona pellucida bacterial infections of, 24 Wharton's jelly, 655 degeneration of, 379 biopsies of, 52~53 myxomatous leiomyomata resembling, 302~303 histology of, 377 blood supply of, 15 White spot disease, 36 sperm penetration of, 345, 735 carcinoma in situ of, 41 ~44 Wild animals, genital tract tumors in, 827~830, Zoo animals, genital tract tumors in, 827~830, chancroid of, 17, 23 836~839 836~839

894 Contributors

Murray R. Abell, M.D., Ph.D. Professor of Pathology University of Michigan· Medical School Ann Arbor, Michigan 48109

Bradley Bigelow, M.D. Associate Professor of Pathology New York University Medical Center School of Medicine New York, New York 10016

Ancel Blaustein, M.D. Clinical Professor of Pathology New York University Medical Center School of Medicine New York, New York 10016 Rita Blaustein, M.D. Attending Cytopathologist Department of Pathology Booth Memorial Medical Center Flushing, New York 11355

John Bonnar, M.A., M.D., F.R.C.O.G. Professor and Head Department of Obstetrics and Gynecology University of Dublin Trinity College Medical School Rotunda Hospital Dublin 1 Ireland

Herbert J. Buchsbaum, M.D. Professor of Obstetrics and Gynecology Director Gynecologic Oncology Service University of Iowa Medical Center Iowa City, Iowa 52242

895 Contributors

E. Cotchin, D.Sc., F.R.C.V.S., F.R.C. Path. June Marchant, Ph.D. Department of Pathology Senior Lecturer in the Biology of Cancer Royal Veterinary College Regional Cancer Registry University of London Queen Elizabeth Medical Centre Camden Town Birmingham B15 2TH London NW1, OTU England England Luigi Mastroianni, Jr., M.D. Bernard Czernobilsky, M.D. Professor and Chairman Chief, Department of Pathology Department of Obstetrics and Gynecology Kaplan Hospital Hospital of the University of Pennsylvania Rehovot University of Pennsylvania Israel Philadelphia, Pennsylvania 19104 Associate Professor of Pathology Medical School of the Hebrew University Jerusalem Lila E. Nachtigal!, M.D. Israel Associate Professor of Obstetrics and Gynecology New York University Medical Center Charles H. Debrovner, M.D. New York, New York 10016 Clinical Associate Professor of Obstetrics and Gynecology New York University School of Medicine Stanley Robboy, M.D. New York, New York 10016 Assistant Professor of Pathology Rita Demopoulos, M.D. Department of Pathology Assistant Professor of Pathology Massachusetts General Hospital Department of Pathology Boston, Massachusetts 02114 New York University School of Medicine New York, New York 10016 Laszlo Sarkozi, Ph.D. Director, Henry Dazian Department of Chemistry Felix de Narvaez, M.D. The Mount Sinai Hospital Adjunct Associate Professor New York, New York Department of Pathology Associate Professor of Clinical Pathology New York University Mount Sinai School of Medicine of the Director of Central Cytopathology Laboratory City University of New York Public Health Department New York, New York New York, New York 10016

Alex Ferenczy, M.D. Robert E. Scully, M.D. Assistant Professor of Pathology Professor of Pathology Department of Pathology Department of Pathology Jewish General Hospital Harvard Medical School Montreal H3T 1E2, Quebec Massachusetts General Hospital Canada Boston, Massachusetts 02114

Eduard G. Friedrich, Jr., M.D. Associate Professor of Gynecology and Obstetrics Lawrence R. Shapiro, M.D. Department of Gynecology and Obstetrics Director of Cytogenetics The Medical College of Wisconsin Letchworth Village Developmental Center Milwaukee, Wisconsin 53226 Thiells, New York 10984 Clinical Associate Professor of Pediatrics Arthur L. Herbst, M.D. and Pathology Professor and Chairman New York Medical College Department of Obstetrics and Gynecology Valhalla, New York 10595 University of Chicago Consultant in Genetics Chicago, Illinois 6063 7 Westchester County Medical Center Valhalla, New York 10595 Jan Langman, M.D., Ph.D. Professor and Chairman Department of Anatomy Lewis Shenker, M.D. School of Medicine Professor of Obstetrics and Gynecology University of Virginia New York University School of Medicine Charlottesville, Virginia 22901 New York, New York 10016

896 Contributors

B. L. Sheppard, M.Sc. (Oxon) James E. Wheeler, M.D. Head of Electron Microscopy Assistant Professor of Pathology at the Department of Obstetrics and Gynaecology University of Pennsylvania School of Medicine University of Dublin Division of Surgical Pathology Trinity College Medical School Hospital of the University of Pennsylvania Rotunda Hospital Philadelphia, Pennsylvania 19104 Dublin 1 A. J. White, M.D., F.A.C.O.G., F.A.C.S. Ireland Gynecology and Gynecologic Oncology 306 Oak Hills Medical Building A. Talerman, M.D., M.R.C. Path. San Antonio, Texas 78229 Department of Pathology Institute of Pathology Edward J. Wilkinson, M.D., F.A.C.O.G., F.A.S.C.P. Institute of Radiotherapy Assistant Professor of Pathology and Gynecology Postbox 5201 Department of Pathology Rotterdam The Medical College of Wisconsin The Netherlands Milwaukee, Wisconsin 53226

897