PERSONAL CARE

innovation beyond expertise About us

ISALTIS is a fine chemicals group mainly serving the life science markets. The group was formed late 2011, after the acquisition of BERNARDY (founded in 1950, ex-affiliate of SPCH) and GIVAUDAN-LAVIROTTE (founded in 1906, ex-affiliate of Seppic), benefiting from more than 100 years of expertise in the production of high purity mineral organic salts. We offer a large range of high quality products for cosmetic and oral care applications: anti acne, antiaging, anti-dandruff, anti-odor. The company is specialized in organic salts. Several studies have shown that such salts have a higher bioavailability and are better tolerated than the inorganic ones such as oxides, carbonates and sulfates.

Thanks to its commitments, Isaltis has become one of the high purity mineral salts key producers. We are operating on a worldwide basis and are exporting more than 80% of our products to over 50 countries on the five continents.

2 P roduct portfolio

CATION TRADE NAME CAS NUMBER INCI NAME

ALUMINIUM Mineralis ® LA/AL 18917-91-4 Aluminium Lactate

CALCIUM Mineralis ® GH/CA 29039-00-7 Calcium Glucoheptonate Mineralis ® GU/CA 66905-23-5 Calcium Gluconate Mineralis ® GY/CA 27214-00-2 Calcium Glycerophosphate Mineralis ® GY/CA L50 27214-00-2 Calcium Glycerophosphate

COPPER Mineralis ® GU/CU 527-09-3 Copper Gluconate

IRON Mineralis ® GH/FE 34459-32-0 Ferrous Glucoheptonate Mineralis ® GU/FE 299-29-6 Ferrous Gluconate

LITHIUM Mineralis ® GU/LI 60816-70-8 Lithium Gluconate

MAGNESIUM Mineralis ® (L)-AP/MG 2068-80-6 Magnesium Aspartate Mineralis ® CI/MG 153531-96-5 Magnesium Citrate Mineralis ® GH/MG 74347-32-3 Magnesium Glucoheptonate Mineralis ® GU/MG 3632-91-5 Magnesium Gluconate Mineralis ® GY/MG 927-20-8 Magnesium Glycerophosphate Mineralis ® GY/MG L50 927-20-8 Magnesium Glycerophosphate Mineralis ® LA/MG 18917-93-6 Magnesium Lactate

MANGANESE Mineralis ® GU/MN 6485-39-8 Manganese Gluconate

POTASSIUM Mineralis ® (L)-AP/K 1115-63-5 Potassium Aspartate Mineralis ® (L)-AP/K-MG 67528-13-6 Magnesium Potassium L-Aspartate Mineralis ® GY/K L50 1319-69-3 Potassium Glycerophosphate Mineralis ® GY/K L75 1319-69-3 Potassium Glycerophosphate Mineralis ® NI/K 7757-79-1 Potassium Nitrate

SODIUM Mineralis ® GY/NA 1555-56-2 Sodium Glycerophosphate Mineralis ® GY/NA L50 1555-56-2 Sodium Glycerophosphate Mineralis ® GY/NA L65 1334-74-3 Sodium Glycerophosphate

STRONTIUM Mineralis ® AC/SR 14692-29-6 Strontium Acetate Mineralis ® CL/SR 10025-70-4 Strontium Chloride Mineralis ® HY/SR 18480-07-4 Strontium Hydroxide Mineralis ® PE/SR 1314-18-7 Strontium Peroxide

ZINC Mineralis ® AC/ZN 557-34-6 Zinc Acetate Mineralis ® (L)-AP/ZN 36393-20-1 Zinc Aspartate Mineralis ® CA/ZN 5263-02-5 Zinc Carbonate Hidroxyde Mineralis ® CI/ZN 546-46-3 Zinc Citrate Mineralis ® GH/ZN 12565-63-8 Zinc Glucoheptonate Mineralis ® GU/ZN 4468-02-4 Zinc Gluconate Mineralis ® LA/ZN 16039-53-5 Zinc Lactate Mineralis ® NI/ZN 10196-18-6 Zinc Nitrate Mineralis ® PE/ZN 1314-22-3 Zinc Peroxide Mineralis ® SA/ZN 16283-36-6 Zinc Salicylate Mineralis ® UN/ZN 557-08-4 Zinc Undecylenate

NICOTINATE 94-44-0 Benzyl Nicotinate

NICOTINATE 614-18-6 Ethyl Nicotinate

NICOTINATE 93-60-7 Methyl Nicotinate

VITAMIN B3 98-92-0 Niacinamide

(1) According to Zinc restriction in cosmetic uses (annexe III of the regulation 1223/2009) (2) Manufactured under GMP conditions REGULATION

CHINA GMP JAPAN EUROPE UNITED PCPC IECIC RESTRICTION STATES

yes (2) yes not listed - CLS 1/ CLS 9 to 10 with restriction 1 % max authorized yes

yes yes not listed - not listed authorized yes yes yes yes - CLS 1 to 7/ CLS 9 to 11 authorized yes yes yes yes - CLS 1 to 7/ CLS 9 to 11 authorized yes yes yes yes - CLS 1 to 7/ CLS 9 to 11 authorized yes

yes yes yes - CLS 1 to 7/ CLS 9 to 11 authorized yes

yes yes not listed - not listed authorized yes yes yes yes - CLS 1 to 7/ CLS 9 to 11 authorized yes

yes yes not listed - not listed authorized yes

yes (2) yes yes - CLS 1 to 7 authorized yes yes (2) yes yes - not listed authorized yes yes yes not listed - not listed authorized yes yes yes yes - not listed authorized yes yes yes yes - not listed authorized yes yes yes yes - not listed authorized yes yes yes yes - not listed authorized yes

yes yes yes - not listed authorized yes

yes yes yes - CLS 1 to 7 authorized yes yes yes not listed - not listed authorized yes yes yes not listed - not listed authorized yes yes yes not listed - not listed authorized yes yes yes yes - CLS 1 to 7/ CLS 9 to 10 authorized yes

yes yes yes - not listed authorized yes yes yes yes - not listed authorized yes yes yes yes - not listed authorized yes

yes yes yes 3.5 % max (as strontium) indexed as prohibited susbtances authorized with restriction: 3.5 % max (as strontium) yes 3.5 % max in oral care, 2.1 % max in hair authorized with restriction: 3.5 % max in oral care, yes yes yes care and face care (as strontium) indexed as prohibited susbtances 2.1 % max hair care and face care (as strontium) yes yes yes yes 3.5 % max (as strontium) indexed as prohibited susbtances authorized with restriction: 3.5 % max (as strontium) yes yes yes yes 4.5 % max (as strontium) indexed as prohibited susbtances authorized with restriction: 4.5 % max (as strontium) yes

- yes yes 1 % max (as zinc) not listed authorized with restriction (1) yes yes (2) yes yes 1 % max (as zinc) not listed authorized with restriction (1) yes - yes yes 1 % max (as zinc) CLS 1 to 7 authorized with restriction (1) yes yes (2) yes yes 1 % max (as zinc) not listed authorized with restriction (1) yes yes (2) yes not listed - not listed authorized with restriction (1) yes yes yes yes 1 % max (as zinc) CLS 1 to 7/ CLS 9 to 11 authorized with restriction (1) yes yes (2) yes yes 1 % max (as zinc) not listed authorized with restriction (1) yes - not listed not listed - not listed authorized with restriction (1) yes - yes yes 1 % max (as zinc) not listed authorized with restriction (1) yes - yes yes 1 % max (as zinc) not listed authorized with restriction (1) yes yes yes yes 1 % max (as zinc) CLS 1/ CLS 2 to 7 and CLS 11 authorized with restriction (1) yes authorized with restriction 3 %

yes yes yes - CLS authorized yes

yes yes not listed - not listed authorized yes

yes yes yes - CLS 1 to 7 with restriction 0.020% authorized yes

yes (2) yes yes - not listed authorized yes

*There are currently no restrictions known on the ISALTIS products in USA 8 PHYSICO-CHEMICAL PROPERTIES

SOLUBILITY in water (g/L) RECOMMENDED DOSAGE

260 (25°C) 1 - 2 %

100 (20°C) 1 - 2 % 40 (25°C) 1 - 2 % 20 (25°C) 1 - 2 % soluble 1 - 2 %

> 500 (20°C) 1 - 2 %

> 1 000 (25°C) 1 - 2 % 100 (20°C) 1 - 2 %

> 1 000 (25°C) 1 - 2 %

1000 (20°C) 1 - 2 % soluble 1 - 2 % > 1 000 (25°C) 1 - 2 % 110 (20°C) 1 - 2 % 80 (20°C) 1 - 2 % soluble 1 - 2 % soluble (at hot temperature) 1 - 2 %

110 (25°C) 1 - 2 %

> 1 000 (25°C) 1 - 2 % > 1 000 (25°C) 1 - 2 % soluble 1 - 2 % soluble 1 - 2 % 350 (20°C) 1 - 2 %

> 1 000 (25°C) 1 - 2 % soluble 1 - 2 % soluble 1 - 2 %

369 (20°C) 1 - 2 % 538 (20°C) 1 - 2 % 4 (20°C) 1 - 2 % compound separation 1 - 2 %

430 (20°C) 1 % max (1) 25 (20°C) 1 % max (1) insoluble 1 % max (1) slightly soluble 1 % max (1) > 1 000 (25°C) 1 % max (1) 100 (20°C) 1 % max (1) 57 (20°C) 1 % max (1) 870 (25°C) 1 % max (1) insoluble 1 % max (1) 50 (20°C) 1 % max (1) insoluble 1 % max (1)

slightly soluble 1 - 2 %

soluble 1 - 2 %

soluble 1 - 2 %

soluble 2 - 5 %

5 PHYSICO-CHEMICAL PROPERTIES

PROPERTIES

Aluminium source - Antimicrobial - Astringent - Buffering agent - Tooth desensivation

Calcium source - Skin conditioner - Increases bioavailability Calcium source - Revitaliser - Restructurer - Moisturizer - Soother Calcium and phosphorous sources - Tooth remineralization - Mineral salt with organic anion vector - Improves bioavailability Calcium and phosphorous sources - Tooth remineralization - Mineral salt with organic anion vector - Improves bioavailability

Copper source - Cellular revitaliser - Modulator of Inflammation process - Immunomodulator - Enzymatic cofactor

Iron source - Skin conditioner Iron source - Keratin restructurer - Improves skin cell defense - Dull and tired skins treatment

Lithium source - Soother - Revitaliser

Magnesium source - Energiser - Restructurer - Immunomodulator Magnesium source - Improves magnesium imbalances in the body Magnesium Source - Skin Conditioner Magnesium source - Restructurer - Membranal protector - Immunomodulator - Revitaliser Magnesium source - Energizer ingredient Magnesium source - Energizer ingredient Magnesium source - Keratolytic agent - Buffering agent - Dough conditioner

Manganese source - Radical scavenger - Energizing ingredient - Restructurer

Potassium source - Energizing ingredient - Restructurer - Skin conditioner Potassium and magnesium sources - Buffering agent - Skin protector Potassium source - Anti-Irritant - Antimicrobial - Dental enamel - Tooth antiplaque Potassium source - Anti-Irritant - Antimicrobial - Dental enamel - Tooth antiplaque Potassium source - Tooth desensivation - Antiplaque

Sodium source - Moisturizer - Restructurer Sodium source - Moisturizer - Restructurer Sodium source - Moisturizer - Restructurer

Strontium source - Tooth desensivation - Soother Strontium source - Tooth desensivation Strontium source - Buffering agent Strontium source - Oxidant - Bleaching agent

Zinc source - Antimicrobial - Skin protector Zinc source - Soother - DNA protector - Immunomodulator energiser - Acne prone skin regulator - Sebum secretion regulator Zinc source - Buffering - Bulking Zinc source - Immunomodulator - Cells and tissue regenerator Zinc source - Skin conditioner Zinc source - Acne prone skin regulator - DNA protector - Soother - Immunomodulator Zinc source - Antimicrobial - Regenerator - Sebum regulation Skin conditioner Zinc source - Oxidant Zinc source - Antimicrobial - Keratolytic agent Anticaking agent - Opacifying agent - Antifungal - Skin soother

Skin-conditioning agent - Miscellaneous - Local vasodilator

Local vasodilator

Soother - Heating agent

Precursor of NAD and NADP - Improves keratin synthesis

6 7 APPLICATIONS

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56 rue Paul Cazeneuve t x e t

69008 Lyon - France t e

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Tel : +33 4 7861 5577 c . m o k - b .

[email protected] w w w • N O I S S

www.isaltis.com E R P M I

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