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CURRÍCULUM ABREVIADO (CVA) – Extensión Máxima CURRÍCULUM ABREVIADO (CVA) – Extensión máxima: 4 PÁGINAS Lea detenidamente las instrucciones disponibles en la web de la convocatoria para rellenar correctamente el CVA Parte A. DATOS PERSONALES Fecha del CVA Julio 2019 Nombre y apellidos MARÍA ÁNGELES CASTRO GONZÁLEZ DNI/NIE/pasaporte Edad Researcher ID K- Núm. identificación del investigador Código Orcid 0000-00 A.1. Situación profesional actual Organismo UNIVERSIDAD DE SALAMANCA Dpto./Centro DPTO. QUÍMICA FARMACÉUTICA/FACULTAD DE FARMACIA Dirección CAMPUS MIGUEL DE UNAMUNO Teléfono 9 correo electrónico [email protected] Categoría profesional CATEDRÁTICA DE UNIVERSIDAD Fecha inicio 17/04/2018 Espec. cód. UNESCO 2306, 2390 CICLOLIGNANOS, TERPENILQUINONA, ANÁLOGOS PRODUCTOS Palabras clave MARINOS, CITOTOXICIDAD, SELECTIVIDAD ANTICANCER A.2. Formación académica (título, institución, fecha) Licenciatura/Grado/Doctorado Universidad Año Licenciatura en Farmacia Universidad de Salamanca 1986 Grado de Salamanca (Tesina) Universidad de Salamanca 1986 Doctorado en Farmacia Universidad de Salamanca 1990 A.3. Indicadores generales de calidad de la producción científica (véanse instrucciones) CATEGORIA PROFESIONAL: Catedrática de Universidad en la Universidad de Salamanca Periodos de actividad investigadora reconocidos: 4 (último periodo reconocido: 2009- 2015). Periodos de actividad docente reconocidos: 6 (último periodo reconocido: 2012-2017). Nº de tesis dirigidas en últimos diez años: 4 Artículos JCR: 75 Citas totales: 1482 Promedio de citas/elemento: 19,76 Promedio de citas/año: 49,40 Publicaciones totales en Q1: 20 Índice h: 21 Parte B. RESUMEN LIBRE DEL CURRÍCULUM (máximo 3500 caracteres, incluyendo espacios en blanco) Inicio de la trayectoria científica con el desarrollo de la Tesis Doctoral en el Departamento de Química Orgánica de la Facultad de Farmacia de Salamanca. Posterior estancia postdoctoral en la Universidad de Aston en Birmingham (UK). Reincorporación a la Universidad de Salamanca, obtención de una plaza de Profesora Titular de Universidad en 1998, y en abril de 2012, la acreditación de la ANECA para Catedrático de Universidad, adquiriendo dicha categoría en abril de 2018. Miembro del GRUPO DE INVESTIGACIÓN DE EXCELENCIA de Castilla y León GR208, (DOMOBIO: Diseño y obtención de moléculas bioactivas) hasta su desaparición en noviembre de 2014 y desde mayo de 2018 pertenezco a la UNIDAD DE INVESTIGACIÓN CONSOLIDADA UIC21 de Castilla y León. Así mismo soy miembro de dos Institutos de Investigación: CIETUS (Centro de investigación en enfermedades tropicales de la Universidad de Salamanca) e IBSAL (Instituto de investigación biomédica de Salamanca). Intereses científicos: diseño, síntesis y evaluación biológica de compuestos bioactivos obtenidos por transformaciones químicas de productos naturales, bien mejorando las propiedades del propio producto natural, bien induciendo bioactividad en compuestos naturales inactivos. En el primer caso, se centra en la manipulación estructural de ciclolignanos derivados de podofilotoxina, campo en el que se ha obtenido resultados sumamente interesantes relacionados con la selectividad citotóxica de estos compuestos y la descripción por primera vez de sus propiedades inmunosupresoras, lo cual dio lugar a dos patentes internacionales. En cuanto a la inducción de bioactividad, se ha conseguido inducir citotoxicidad en diferentes terpenoides inactivos, formando una nueva familia de compuestos denominados terpenilquinonas, los cuales presentan una citotoxicidad por debajo de 1 CURRÍCULUM ABREVIADO (CVA) – Extensión máxima: 4 PÁGINAS Lea detenidamente las instrucciones disponibles en la web de la convocatoria para rellenar correctamente el CVA micromolar. Los resultados obtenidos se resumen a continuación: No de Tesis codirigidas: 12 No de Tesinas codirigidas: 19 Trabajos de Fin de Grado 20 Trabajos Fin de Master: 18 Supervisión de estancias de investigación en nuestro laboratorio de estudiantes extranjeros (Reino Unido, Alemania, República Checa, Italia, Brasil, Chile, Perú, Venezuela, Nicaragua) que han realizado estancias de pregrado, postgrado y postdoctorales, de duración variable que van desde tres meses a dos años. Participación en proyectos y contratos de investigación: Proyectos europeos: 1 Proyectos nacionales: 11 (1 IP) Proyectos regionales: 13 (3 IP) Proyectos AECI-ICI: 1 (IP) Otros proyectos: 4 (1 IP) Más de 75 publicaciones en revistas internacionales de reconocido prestigio en el ámbito de la Química Orgánica y la Química Farmacéutica, algunas de ellas son el resultado de colaboraciones con grupos de investigación tanto nacionales como europeos e iberoamericanos. Algunas de las revistas en las que se ha publicado se incluyen entre las mejores de su categoría como por ejemplo: J. Med. Chem. (IF: 6,253. Posición en su categoría: 3/59) Eur. J. Med. Chem. (IF: 4,816. Posición en su categoría: 4/59) Marine Drugs (IF: 4,379. Posición en su categoría: 5/59) ACS Med. Chem. Lett. (IF: 3,794. Posición en su categoría: 12/59) Biochem. Pharmacol. (IF: 4,235. Posición en su categoría: 36/261) Chem. Commun. (IF: 6,290. Posición en su categoría: 28/170) RSC Advances (IF: 2,936. Posición en su categoría: 71/170) Bioorg. Med. Chem. (IF: 2,881. Posición en su categoría: 24/59) Etc 2 Patentes internacionales. 3 Capítulos de libro. Participación en más de 100 Congresos nacionales e internacionales especializados en el ámbito de la Química Orgánica y la Química Farmacéutica con presentación de varias conferencias invitadas, comunicaciones orales y poster. Parte C. MÉRITOS MÁS RELEVANTES (ordenados por tipología) C.1. Publicaciones (últimos diez años) Roa-Linares, V.C.; Miranda-Brand, Y.; Tangarife-Castaño, V.; Ochoa, R.; García, P.A. ; Castro, M.A.; Betancur-Galvis L.A.; San Feliciano, A. “Anti-herpetic, anti-Dengue and antineoplastic activities of simple and heterocycle-fused derivatives of terpenyl-1,4- naphthoquinone and 1,4-anthraquinone” Molecules, 2019, 24, 1279. P.A. García, A.P. Hernández, A. San Feliciano, M.A. Castro. “Bioactive prenyl- and terpenyl- quinones/hydroquinones of marine origin” Mar. Drugs, 2018, 16, 292 A.P. Hernández, P. Díez, P.A. García, J.M. Miguel del Corral, M. Pérez-Andrés, D. Díez, A. San Feliciano, M. Fuentes, M.A. Castro. “New hybrids derived from podophyllic aldehyde and diterpenylhydroquinones with selectivity towards osteosarcoma cells”. ACS Med. Chem. Lett., 2018, 9, 328-333. P.A. García, E. Valles, D. Díez, M.A. Castro. Marine Alkylpurines: a promising group of bioactive marine natural products. Mar. Drugs, 2018, 16, 6 J.M. Escudero-Martínez, Y. Pérez-Pertejo, R.M. Reguera, M.A. Castro, M.V. Rojo, C. Santiago, A. Abad, P.A. García, J.L. López-Pérez, A. San Feliciano. “Antileishmanial activity and tubulin polymerization inhibition of podophyllotoxin derivatives on Leishmania Infantum.” Int. J. Parasitol: Drugs and Drugs Resistance, 2017, 7, 272-285. M. Miguel, L. Barros, C. Pereira, R.C Calhelha, P.A. García, M.A. Castro, C. Santos-Buelga, I.C.F.R. Ferreira. “Chemical characterization and bioactive properties of two aromatic plants: Calendula Officinalis L. (Flowers) and Mentha Cervina L. (Leaves). Food & Funct. 2016, 7, 2223-2232. M.A. Castro, P.A. García, A.P. Hernández, D. Díez. “An overview on heterocyclic podophyllotoxin derivatives” in Targets in Heterocyclic Systems. Chemistry and Properties vol 19, Eds.: O.A. Attanasi, P. Merino, D. Spinelli. pp:28-61. Società Chimica Italiana. 2016. 2 CURRÍCULUM ABREVIADO (CVA) – Extensión máxima: 4 PÁGINAS Lea detenidamente las instrucciones disponibles en la web de la convocatoria para rellenar correctamente el CVA Castro, M. A.; Gamito, A.M.; Tangarife-Castaño, V.; Roa-Linares, V.; Miguel del Corral, J. M.; Mesa-Arango A.C.; Betancur-Galvis L.A.; Francesch, A.M.; San Feliciano, A. “New 1,4- anthracenedione derivatives with fused heterocyclic rings: synthesis and biological evaluation”. RSC Advances. 2015, 5, 1244-1261. Castro, M. A.; Gamito, A.M.; Tangarife-Castaño, V.; Zapata, B.; Miguel del Corral, J. M. ; Mesa-Arango A.C.; Betancur-Galvis L.A.; San Feliciano, A. “Synthesis and antifungal activity of terpenyl-1,4-naphthoquinone and 1,4-anthracenedione derivatives”. Eur. J. Med. Chem. 2013, 67, 19-27. Batista, R.; García, P. A. ; Castro, M. A. ; Miguel del Corral, J. M. ; Speziuali, N.L.; Varotti, F.P.; de Paula, R.C.; García-Fernández, L.F.; Francesch, A.; San Feliciano, A. ; de Oliveira, A.B. “Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives”. Eur. J. Med. Chem. 2013, 62, 168-176. Castro, M.A.; Miguel del Corral, J.M. ; García, P.A. ; M. V. Rojo; A.C. Bento; F. Mollinedo; A. Francesch; San Feliciano, A. “Lignopurines: a new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation”. Eur. J. Med. Chem. 2012, 58, 377-389. San Feliciano, A., Castro, M.A., López-Pérez, J.L., Olmo, E. “The importance of structural manipulation of natural compounds in drug discovery and development” in Plant Bioactives and Drug Discovery. Principles, practice and perspectives. Ed.: V. Cechinel-Filho. pp: 127- 160 John Wiley & Sons, 2012. M.A. Castro, J.M. Miguel del Corral, P.A. García, M.V. Rojo, J. de la Iglesia-Vicente, F. Mollinedo, C. Cuevas, A. San Feliciano. “Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activities”. J. Med. Chem. 2010, 53, 983-993. C.2. Proyectos Referencia: CTQ2015-68175-R Título del proyecto: Nuevas estrategias de síntesis y funcionalización de analgésicos y citotóxicos Entidad financiadora: MINECO Investigador responsable:
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