A Legacy of Lancashire Its Chemists, Biochemists and Industrialists
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Metabolomic Assessment of Dietary Interventions in Obesity by Capillary Electrophoresis Mass Spectrometry
Metabolomic Assessment of Dietary Interventions in Obesity by Capillary Electrophoresis Mass Spectrometry Metabolomic Assessment of Dietary Interventions in Obesity by Capillary Electrophoresis Mass Spectrometry By Karen Phoebe Lam, H.B.Sc., M.Sc. A Thesis Submitted to the School of Graduate Studies in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy McMaster University © Copyright by Karen Phoebe Lam, July 2018 Doctor of Philosophy (2018) McMaster University (Department of Chemisty & Chemical Biology) Hamilton, Ontario TITLE: Metabolomic Assessment of Dietary Interventions in Obesity by Capillary Electrophoresis Mass Spectrometry AUTHOR: Karen Phoebe Lam, H.B.Sc. (University of Toronto), M.Sc. (McMaster University) SUPERVISOR: Professor Philip Britz-McKibbin NUMBER OF PAGES: xxix, 347 ii Abstract Capillary electrophoresis mass spectrometry (CE-MS) is a versatile instrumental method for metabolomics, which allows for comprehensive metabolite profiling of volume-limited biological specimens in order to better understand the molecular mechanisms associated with chronic diseases, including an alarming epidemic of obesity worldwide. Multiplexed CE separations enable high-throughput metabolite screening with quality assurance to prevent false discoveries when combined with rigorous method validation, robust experimental designs, complementary statistical methods, and high-resolution tandem mass spectrometry (MS/MS) for unknown metabolite identification. In this thesis, multiplexed CE-MS technology is applied for both targeted and untargeted metabolite profiling of various biological fluids, including covalently bound thiol-protein conjugates, as well as free circulating metabolites in serum and plasma, and excreted/bio-transformed compounds in urine due to complex host-gut microflora co-metabolism. This work was applied to characterize aberrant metabolic responses of obese subjects in response to dietary challenges, and measure the benefits of dietary interventions that reduce adiposity without deleterious muscle loss. -
Crystallography News British Crystallographic Association
Crystallography News British Crystallographic Association Issue No. 100 March 2007 ISSN 1467-2790 BCA Spring Meeting 2007 - Canterbury p8-17 Patrick Tollin (1938 - 2006) p7 The Z’ > 1 Phenomenon p18-19 History p21-23 Meetings of Interest p32 March 2007 Crystallography News Contents 2 . From the President 3 . Council Members 4 . BCA Letters to the Editor 5 Administrative Office, . Elaine Fulton, From the Editor 6 Northern Networking Events Ltd. 7 1 Tennant Avenue, Puzzle Corner College Milton South, . East Kilbride, Glasgow G74 5NA Scotland, UK Patrick Tollin (1938 - 2006) 8-17 Tel: + 44 1355 244966 Fax: + 44 1355 249959 . e-mail: [email protected] BCA 2007 Spring Meeting 16-17 . CRYSTALLOGRAPHY NEWS is published quarterly (March, June, BCA 2007 Meeting Timetable 18-19 September and December) by the British Crystallographic Association, . and printed by William Anderson and Sons Ltd, Glasgow. Text should The Z’ > 1 Phenomenon 20 preferably be sent electronically as MSword documents (any version - . .doc, .rtf or .txt files) or else on a PC disk. Diagrams and figures are most IUCr Computing Commission 21-23 welcome, but please send them separately from text as .jpg, .gif, .tif, or .bmp files. Items may include technical articles, news about people (e.g. History . 24-27 awards, honours, retirements etc.), reports on past meetings of interest to crystallographers, notices of future meetings, historical reminiscences, Groups .......................................................... 28-31 letters to the editor, book, hardware or software reviews. Please ensure that items for inclusion in the June 2007 issue are sent to the Editor to arrive Meetings . 32 before 25th April 2007. -
Institution: University of Nottingham Unit of Assessment: Uoa 8 (Chemistry) A
Environment template (REF5) Institution: University of Nottingham Unit of Assessment: UoA 8 (Chemistry) a. Overview: The School is returning 42 category A researchers (100% of eligible staff), including 25 Professors (two FRSs$), 8 Associate Professors, 4 Lecturers and 5 fixed-term Research Fellows (denoted*). Our research, impact and industry engagement has attracted international recognition in the following overlapping thematic areas: • Theoretical and Computational Chemistry: Besley, Bichoutskaia, Hirst, Robinson*, Teale*, Wheatley. • Molecular Structure and Spectroscopy: George, Jones, Powis, Reid, Sarre, Stace$, Wright. • Chemical and Structural Biology: Dowden, Oldham, Searle, Soultanas, Thomas. • Sustainable Synthesis and Catalysis: Denton, Hayes, Kays, Lam, Licence, Liddle, Lygo, McMaster, Moody, Moses, Poliakoff $, Stockman, Woodward. • Functional Materials and Nanosciences: Blake, Champness, Gibson*, Gimenez-Lopez*, Howdle, Khlobystov, Mokaya, Schröder, Titman, Walsh, Yang*. b. Research strategy b1: Achievement of strategic aims stated in RAE2008: 1. Achieving a Sustainable Research Environment. Our aims since 2008 have been to strengthen our research at the interfaces between Chemistry and other physical sciences, the life sciences and engineering. We have built upon our strong research base and have ensured the sustainability and vitality of our environment by the strategic allocation of resources, major investments in instrumentation and infrastructure to provide world-class facilities (see d), and by nurturing Early Career Researchers (ECRs, see c1). The School has exploited new research opportunities and driven national research priorities by engagement in EPSRC Portfolio Shaping, membership of SATs and boards of UK facilities (see e3). We have strengthened our knowledge exchange activities with industry (see e2) and the public to increase research impact, and have built critical mass in research and training (see e1). -
Historical Group
Historical Group NEWSLETTER and SUMMARY OF PAPERS No. 61 Winter 2012 Registered Charity No. 207890 COMMITTEE Chairman: Prof A T Dronsfield, School of Education, | Prof J Betteridge (Twickenham, Middlesex) Health and Sciences, University of Derby, | Dr N G Coley (Open University) Derby, DE22 1GB [e-mail [email protected]] | Dr C J Cooksey (Watford, Hertfordshire) Secretary: | Prof E Homburg (University of Maastricht) Prof W P Griffith, Department of Chemistry, | Prof F James (Royal Institution) Imperial College, South Kensington, London, | Dr D Leaback (Biolink Technology) SW7 2AZ [e-mail [email protected]] | Dr P J T Morris (Science Museum) Treasurer; Membership Secretary: | Prof. J. W. Nicholson (University of Greenwich) Dr J A Hudson, Graythwaite, Loweswater, | Mr P N Reed (Steensbridge, Herefordshire) Cockermouth, Cumbria, CA13 0SU | Dr V Quirke (Oxford Brookes University) [e-mail [email protected]] | Dr S Robinson (Ham, Surrey) Newsletter Editor: | Prof. H. Rzepa (Imperial College) Dr A Simmons, Epsom Lodge, | Dr. A Sella (University College) La Grande Route de St Jean,St John, Jersey, JE3 4FL [e-mail [email protected]] Newsletter Production: Dr G P Moss, School of Biological and Chemical, Sciences Queen Mary University of London, Mile End Road, London E1 4NS [e-mail [email protected]] http://www.chem.qmul.ac.uk/rschg/ http://www.rsc.org/membership/networking/interestgroups/historical/index.asp Contents From the Editor 2 RSC Historical Group News - Bill Griffith 3 Identification Query - W. H. Brock 4 Members’ Publications 5 NEWS AND UPDATES 6 USEFUL WEBSITES AND ADDRESSES 7 SHORT ESSAYS 9 The Copperas Works at Tankerton - Chris Cooksey 9 Mauveine - the final word? (3) - Chris Cooksey and H. -
Stoddart Research Professor of Chemistry, a Position Northwestern University He Held Until His Death in 1977
PREVIOUS J.K.N. JONES JONES LECTURERS John Kenyon Netherton Jones, Ph.D. Department of Chemistry Birmingham University. Assistant lecturer Queen’s University and then lecturer at Bristol University 1936- 2011 • J.A. Caruso 1944, he was engaged in munitions research and training during the Second World War. 2010 • T. Marks He resigned at the end of the war with the is honoured to host the rank of captain, and returned to academic 2012 Jones Lecturer: work as senior lecturer at Manchester 2010 • G. van Koten University 1945-1948 and then as reader in chemistry at Bristol University 1948-1953. 2009 • P.B. Corkum He came to Queen's in 1953 as Chown Prof. J Fraser Stoddart Research Professor of Chemistry, a position Northwestern University he held until his death in 1977. 2008 • M. Gruebele Evanston, Illinois, USA Professor Jones' outstanding achievements in carbohydrate chemistry were recognized by 2005 • W. Klemperer his election as Fellow of the Royal Society of London in 1957 and of the Royal Society of Canada in 1959. The Division of 2001 • G. Ozin Carbohydrate Chemistry of the American Chemical Society presented him with the 1997 • M.S. Brookhart Claude S. Hudson Award in 1969, and in 1975 he received the Anselme Payen Award from the Cellulose, Paper and Textile 1993 • B.O. Fraser-Reid Public Lecture Division. In March 1975 he was awarded the third Sir Norman Haworth Memorial Medal of “Mingling Art with Science” The Chemical Society (London). 1990 • S. Hanessian Professor Jones was, at all times, an Thursday, March 22, 2012 educator of the highest rank and an 1982 • R. -
Vitamin C: Prevention of Chronic Diseases and Optimal Doses
NFT 9-2010 s. 20-27 08.09.10 13.00 Side 20 Vitenskap Review Vitamin C: Prevention of Chronic Diseases and Optimal Doses TEXT: Purusotam Basnet, Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, e-mail: [email protected] INTRODUCTION acid because of its anti-scorbutic property ABSTRACT It has been known for a long time that (Latin word scorbutus = scurvy). In absence of fresh fruit and vegetables in the solution, it releases a proton to give an The role of vitamin C in prevention and human diet leads to scurvy, a fatal disease anion called ascorbate. Ascorbate easily treatment of scurvy is well accepted. In widely described throughout written transfers one electron and one additional spite of having long history as the candidate of alternative therapy for the history (Lind, 1753). Later, it was dis - proton and can remains in the stable prevention and treatment of cancer, still covered that ascorbic acid in fresh fruits radical form as semidehydroascorbate there is no common conclusion on the and vegetables prevents scurvy and that is (SDA), a state in between dehydroa- topic. However, its biochemical reaction why it is a vitamin for humans and must be scorbic acid (DHA) and ascorbate in the as an antioxidant and its immuno- a part of human diet (Mandl et al., 2009). physiological condition (figure 1). stimulating effects drew further Among the long list of people who Because of the unique electron trans- attention towards its health beneficial contributed to the knowledge regarding ferring capability, ascorbate plays a vital effects. Current official recommended vitamin C, three Nobel prize-winners are in role in living cells. -
The Correspondence of Julius Haast and Joseph Dalton Hooker, 1861-1886
The Correspondence of Julius Haast and Joseph Dalton Hooker, 1861-1886 Sascha Nolden, Simon Nathan & Esme Mildenhall Geoscience Society of New Zealand miscellaneous publication 133H November 2013 Published by the Geoscience Society of New Zealand Inc, 2013 Information on the Society and its publications is given at www.gsnz.org.nz © Copyright Simon Nathan & Sascha Nolden, 2013 Geoscience Society of New Zealand miscellaneous publication 133H ISBN 978-1-877480-29-4 ISSN 2230-4495 (Online) ISSN 2230-4487 (Print) We gratefully acknowledge financial assistance from the Brian Mason Scientific and Technical Trust which has provided financial support for this project. This document is available as a PDF file that can be downloaded from the Geoscience Society website at: http://www.gsnz.org.nz/information/misc-series-i-49.html Bibliographic Reference Nolden, S.; Nathan, S.; Mildenhall, E. 2013: The Correspondence of Julius Haast and Joseph Dalton Hooker, 1861-1886. Geoscience Society of New Zealand miscellaneous publication 133H. 219 pages. The Correspondence of Julius Haast and Joseph Dalton Hooker, 1861-1886 CONTENTS Introduction 3 The Sumner Cave controversy Sources of the Haast-Hooker correspondence Transcription and presentation of the letters Acknowledgements References Calendar of Letters 8 Transcriptions of the Haast-Hooker letters 12 Appendix 1: Undated letter (fragment), ca 1867 208 Appendix 2: Obituary for Sir Julius von Haast 209 Appendix 3: Biographical register of names mentioned in the correspondence 213 Figures Figure 1: Photographs -
Financial Statements and Trustees' Report 2017
Royal Society of Chemistry Financial Statements and Trustees’ Report 2017 About us Contents We are the professional body for chemists in the Welcome from our president 1 UK with a global community of more than 50,000 Our strategy: shaping the future of the chemical sciences 2 members in 125 countries, and an internationally Chemistry changes the world 2 renowned publisher of high quality chemical Chemistry is changing 2 science knowledge. We can enable that change 3 As a not-for-profit organisation, we invest our We have a plan to enable that change 3 surplus income to achieve our charitable objectives Champion the chemistry profession 3 in support of the chemical science community Disseminate chemical knowledge 3 and advancing chemistry. We are the largest non- Use our voice for chemistry 3 governmental investor in chemistry education in We will change how we work 3 the UK. Delivering our core roles: successes in 2017 4 We connect our community by holding scientific Champion for the chemistry profession 4 conferences, symposia, workshops and webinars. Set and maintain professional standards 5 We partner globally for the benefit of the chemical Support and bring together practising chemists 6 sciences. We support people teaching and practising Improve and enrich the teaching and learning of chemistry 6 chemistry in schools, colleges, universities and industry. And we are an influential voice for the Provider of high quality chemical science knowledge 8 chemical sciences. Maintain high publishing standards 8 Promote and enable the exchange of ideas 9 Our global community spans hundreds of thousands Facilitate collaboration across disciplines, sectors and borders 9 of scientists, librarians, teachers, students, pupils and Influential voice for the chemical sciences 10 people who love chemistry. -
Industrialism, Androids, and the Virtuoso Instrumentalist
UNIVERSITY OF CALIFORNIA Los Angeles Performing the Mechanical: Industrialism, Androids, and the Virtuoso Instrumentalist A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Musical Arts by Leila Mintaha Nassar-Fredell 2013 © Copyright by Leila Mintaha Nassar-Fredell 2013 ABSTRACT OF THE DISSERTATION Performing the Mechanical: Industrialism, Androids, and the Virtuoso Instrumentalist by Leila Nassar-Fredell Doctor of Musical Arts University of California, Los Angeles, 2013 Professor Robert S. Winter, Chair Transactions between musical androids and actual virtuosos occupied a prominent place in the music of the eighteenth and nineteenth centuries. Instrumentalists and composers of instrumental music appropriated the craze for clockwork soloists, placing music in a position of increased social power in a society undergoing rapid technological transformation. The history of musical automata stretches back to antiquity. Androids and automata, vested by audiences with spiritual and magical qualities, populated the churches of the broader populations and the Renaissance grottos of the aristocracy. As ii the Industrial Revolution began, automata increasingly resembled the machines changing the structure of labor; consequently, androids lost their enchanted status. Contemporary writers problematized these humanoid machines while at the same time popularizing their role as representatives of the uncanny at the boundaries of human identity. Both instrumental performers and androids explored the liminal area between human and machine. As androids lost their magic, musical virtuosos assumed the qualities of spectacle and spirituality long embodied by their machine counterparts. In this process virtuosi explored the liminal space of human machines: a human playing a musical instrument (a machine) weds the body to a machine, creating a half-human, half-fabricated voice. -
History of Science and History of Technology (Class Q, R, S, T, and Applicable Z)
LIBRARY OF CONGRESS COLLECTIONS POLICY STATEMENTS History of Science and History of Technology (Class Q, R, S, T, and applicable Z) Contents I. Scope II. Research strengths III. General collecting policy IV. Best editions and preferred formats V. Acquisitions sources: current and future VI. Collecting levels I. Scope This Collections Policy Statement covers all of the subclasses of Science and Technology and treats the history of these disciplines together. In a certain sense, most of the materials in Q, R, S, and T are part of the history of science and technology. The Library has extensive resources in the history of medicine and agriculture, but many years ago a decision was made that the Library should not intensively collect materials in clinical medicine and technical agriculture, as they are subject specialties of the National Library of Medicine and the National Agricultural Library, respectively. In addition, some of the numerous abstracting and indexing services, catalogs of other scientific and technical collections and libraries, specialized bibliographies, and finding aids for the history of science and technology are maintained in class Z. See the list of finding aids online: http://findingaids.loc.gov/. II. Research strengths 1. General The Library’s collections are robust in both the history of science and the history of technology. Both collections comprise two major elements: the seminal works of science and technology themselves, and historiographies on notable scientific and technological works. The former comprise the original classic works of science and technology as they were composed by the men and women who ushered in the era of modern science and invention. -
Early Russian Organic Chemists and Their Legacy
SpringerBriefs in Molecular Science Early Russian Organic Chemists and Their Legacy Bearbeitet von David Lewis 1. Auflage 2012. Taschenbuch. xii, 136 S. Paperback ISBN 978 3 642 28218 8 Format (B x L): 15,5 x 23,5 cm Gewicht: 237 g Weitere Fachgebiete > Chemie, Biowissenschaften, Agrarwissenschaften > Chemie Allgemein > Geschichte der Chemie Zu Inhaltsverzeichnis schnell und portofrei erhältlich bei Die Online-Fachbuchhandlung beck-shop.de ist spezialisiert auf Fachbücher, insbesondere Recht, Steuern und Wirtschaft. Im Sortiment finden Sie alle Medien (Bücher, Zeitschriften, CDs, eBooks, etc.) aller Verlage. Ergänzt wird das Programm durch Services wie Neuerscheinungsdienst oder Zusammenstellungen von Büchern zu Sonderpreisen. Der Shop führt mehr als 8 Millionen Produkte. Chapter 2 Beginnings 2.1 Introduction At the start of the twentieth century, organic chemistry was not yet 75 years old as a separate and legitimate sub-discipline of the science. Considerable progress had been made in these first seven decades, and the stage was set for the dramatic advances in the science to come in the following century. Most practicing organic chemists are familiar with many of the great German, French and English organic chemists whose work helped the fledgling discipline grow, but few are familiar with the role that Russian organic chemists of the nineteenth and early twentieth century played in the development of the science. And this is in spite of the fact that many of the named rules and reactions that one studies in the first course in organic chemistry are, in fact, of Russian origin. It is the intent of this book to help rectify that deficiency. -
The Rise of Bolton As an Important Engineering and Textile Town in Early 1800 England
I. međunarodna konferencija u povodu 150. obljetnice tvornice torpeda u Rijeci i očuvanja riječke industrijske baštine 57 THE RISE OF BOLTON AS AN IMPORTANT ENGINEERING AND TEXTILE TOWN IN EARLY 1800 ENGLAND Denis O’Connor, Industrial Historian Bolton Lancashire, Great Britain INTRODUCTION The aim of this paper is to demonstrate that Great Britain changed, in the 19th Century, from a rural economy to one based on coal and iron. In doing so it created conditions for British civil, textile and mechanical engineers, such as Robert Whitehead of Bolton, to rise to positions of eminence in their particular fields. Such men travelled across Europe, and laid, through the steam engine and railways, the foundations for many of the regions present day industries. EARLY TEXTILES AND BLEACHING. RISE OF LOCAI INDUSTRIES The origins of Bolton’s textile and engineering industry lie back in the 12th Century with the appointment of a Crown Quality Controller called an Ulnager. During the reign of Henry V111 an itinerant historian Leland observed that ‘Bolton - upon - Moore Market standeth by the cotton and coarse yarns - Diverse villages above Bolton do make Cotton’ and that ‘They burne at Bolton some canelle (coal) of which the Pitts be not far off’. Coal, combined with the many powerful streams of water from the moorlands, provided the basic elements for the textile industry to grow, the damp atmosphere conducive to good spinning of thread. In 1772 a Directory of Manchester (10-12 miles distant) was published, in this can be seen the extent of cloth making in an area of about 12 miles radius round Manchester, with 77 fustian makers (Flax warp and cotton or wool weft) attending the markets, 23 of whom were resident in Bolton.