2020 Contribution of Women Scientists In
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NO TRONO DA CIÊNCIA I: MULHERES NO NOBEL DA FISIOLOGIA OU MEDICINA (1947-1988) Elas Proferiramduranteassolenidadesdepremiação
TEMA EM DESTAQUE NO TRONO DA CIÊNCIA I: MULHERES NO NOBEL DA FISIOLOGIA OU MEDICINA (1947-1988) LUZINETE SIMÕES MINELLA RESUMO NO TRONO DA CIÊNCIA I: MULHERES NO NOBEL DA FISIOLOGIA OU MEDICINA (1947-1988) FISIOLOGIA CIÊNCIA I: MULHERES NO NOBEL DA NO TRONO DA O artigo reflete sobre as trajetórias das cinco cientistas que receberam o Nobel na Fisiologia ou Medicina entre 1947 e 1988, abordadas como as pioneiras dessa área no curso desta premiação criada em 1901. Numa perspectiva balizada pelos avanços da crítica feminista à ciência, dos campos de gênero e ciências e da história das ciências, o artigo sintetiza vários aspectos ligados às origens e formação dessas mulheres, ressaltando as interferências de gênero na construção das suas carreiras. A discussão visa a contribuir para o debate sobre a categoria feminização. Foram consultadas várias fontes, entre elas o site do prêmio no qual podem ser encontradas suas autobiografias, bem como os discursos e palestras que elas proferiram durante as solenidades de premiação. MULHERES • PRÊMIO NOBEL • FISIOLOGIA • MEDICINA IN THE REALM OF SCIENCE I: WOMEN NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE (1947-1988) ABSTRACT The article discusses the path of the five women scientists who received the Nobel Prize in Physiology or Medicine, between 1947 and 1988, regarded as pioneers in this area in the course of this award created in 1901. In a perspective marked by advances in feminist criticism of science, in the fields of gender and science and the history of science, this article summarizes various aspects linked to the v.47 n.163 p.70-93 jan./mar. -
Front Matter (PDF)
BectonDickinson RVCSSystems ADVANCESIN CELLBIOLOGY The Fluorescence Activated Cell Cell Cycle after Simian test of mouse spleen cells reacted with Sorter (FACS) has become a powerful Virus-40 Infection varying dilutions of rabbit anti-mouse means of identifying and separating FACS has been used to study the T-cell antiserum plus complement has cells and cell constituents according to interplay between Simian Virus-40 shown that as antiserum concentration distinctive properties of FLUORESCENCE (SV-40) and host cells after infection increases, the percentage of cells in the and SIZE.FACS makes possible multi- of growing cell cultures. Both mock- dead subpopulation also increases. parameter measurement of individual and SV-40 infected cultures have been cells, providing the distribution of Sorting of Erythrocytes harvested at 24 to 48 hours after infec Containing Malaria Parasites these measurements in a sample. tion, stained for DNA content, and Plasmodium berghei-mtecied mouse Evaluation against operator-selected analyzed with FACS for cell cycle dis criteria, at rates to 5,000 cells per tribution. Infected cultures exhibited a erythrocytes can be analyzed and second, forms the basis for physical marked shift to above average G2 sorted on the basis of parasite DNA separation of viable subpopulations. content. Infected cells, treated with a DNA content by 24 hours after infec vital DNA-binding dye, fluoresce FACS measurements have been docu tion, and remained in this state for at mented for sensitivity to as few as with intensity corresponding to the least 24 hours further, indicating that number of parasites contained. Unin- 3,000 fluorescent molecules per cell. after infection, cycling cells completed Light-scatter measurements are sensi one round of DNA synthesis, but fected cells are nonfluorescent. -
The Research Imperative Arnold Theiler Memorial Lecture 2017
The Research Imperative Arnold Theiler Memorial Lecture 2017 Robert O. Gilbert, FRCVS Professor, Ross University School of Veterinary Medicine Professor Emeritus, Cornell University Outline • Personal research in postpartum uterine disease of dairy cows • Reflections on research more generally • Production animal research • Research in veterinary practice • Academic practice • Private practice • The research imperative • For Society and the Profession • For Universities • For individuals Up to circa 1990 • Most agreed “endometritis” was bad for reproduction • Several disagreed • Miller HV, et al., Bov.Pract. 1980 • Griffin, Hartigan & Nunn, Theriogenology, 1974 a,b • Diagnosis • N. America: palpation and visible exudate • Incidence < 20 % • Europe: vaginoscopy • Incidence ~ 40 % Maurice E. “Pete” White Editor, Cornell Veterinarian Creator, “Consultant” Bovine Endometritis: The burden of proof. Cornell Vet., 1992 Endometrial cytology Endometrial cytology Endometritis • Cows at 40 – 60 days postpartum • End of voluntary waiting period • 5 dairy herds in Central New York • Endometrial cytology • No further involvement in management • Followed up via dairy records Endometritis Survival Analysis Effect of Endometritis at 7 weeks 1.0 Endometritis-negative Endometritis-positive 0.8 0.6 122 days 158 days P = 0.002 Proportion Open 0.4 30% censored 0.2 P = 0.003 18% censored 0.0 0 50 100 150 200 250 300 350 Time (Days) Some central questions • Which pathogens are primarily responsible for endometritis? • Which metabolic and immune factors mediate susceptibility to and pathogenesis of endometritis? • How does endometritis mediate infertility? Which pathogens cause endometritis? • Most cows have postpartum uterine bacterial infection • Only a subset develops disease • Extensively studied by conventional means • Mixed postpartum population initially judged to be insignificant (Griffin, Hartigan, Nunn, 1974) • Persistence of Trueperella pyogenes beyond 21 days detrimental to fertility • Synergistic action of T. -
WOMEN in STEM WORD SEARCH Learn About Women Scientists Who Broke MARY JACKSON Boundaries and Made Important Discoveries Credit: NASA
WOMEN IN STEM WORD SEARCH Learn about women scientists who broke MARY JACKSON boundaries and made important discoveries Credit: NASA V WANGARIMAATHAIMEQNW QAWAZSXEDCFRVGHAITIA XMLONOSKCAJYRAMRRPLL ZAPELNMTIOPYBNMYUIKK ORBINJANEGOODALLCRNC NYDBATRKJLXDTOCEEAAO IGOAQSIDFYOWRNBAICRT KONGHJMNOQPEVAMKRHFN GLNZXCAVALNLLUQEAEDI DDABNMEWETRLYXKYMLNL OASPOIJUIIEFERLDSCIC HRTAZWEESKXRAEQTSALC YOREYAMTREPPEOGAIRAM HSIWEEIXRYATYSUJMSSA TSCESOSRAHYNMPHIKOOR OAKIDSOATGPMOERKINRA RVLFAPNRNRTUYOUYOUQB OWAERTEYMDGUOFXBCVOR DENXOBIVANDANASHIVAA MMDYLADDRANYAMEIRAMB Answer key on page 4 Alice Ball Mae Jemison Rachel Carson Barbara McClintock Marie Curie Rosalind Franklin Bertha Parker Marie Maynard Daly Tu Youyou Donna Strickland Maria Goeppert Mayer Valentina Tereshkova Dorothy Hodgkin Mary Golda Ross Vandana Shiva Jane Goodall Mary Jackson Wangari Maathai An agency of the Lise Meitner Mary Leakey Government of Ontario WOMEN IN STEM WORD SEARCH Learn about women scientists who broke MAE JEMISON boundaries and made important discoveries Credit: NASA 1. Marie Curie (1867-1934) Polish-born French physicist and chemist. She was the first woman to be awarded a Nobel Prize (Physics), in 1903, for her research on X-rays and radioactivity, and the first person to be awarded a second Nobel Prize (Chemistry), in 1911, for her discovery of the elements polonium and radium. 2. Lise Meitner (1878-1968) Austrian-born nuclear physicist. Her research led to the discovery of uranium fission, for which only her male colleague, Otto Hahn, was awarded the Nobel Prize in 1945. 1n 1997, an element was named meitnerium (Mt) in her honour. 3. Alice Ball (1892-1916) Black American chemist. She developed the first effective treatment for leprosy, later known as the Ball Method, which was widely used for over thirty years until the introduction of sulfone drugs. 4. Maria Goeppert Mayer (1906-1972) German-born American mathematician and physicist. -
KITCHEN CHEMISTRY Bijeta Roynath & Prasanta Kumar Sahoo
Test Your Knowledge KITCHEN CHEMISTRY Bijeta Roynath & Prasanta Kumar Sahoo 1. The common cooking fuel, Liquefied Petroleum Gas 10. Which of the following could be produced by the gas (LPG), is a mixture of two hydrocarbons. These are: stove? (a) Methane and Butane (b) Propane and Butane (a) Nitrogen Oxides (b) Sulphur dioxides (c) Oxygen and Hydrogen (d) Hexane and Propane (c) Carbon monoxide (d) Dihydrogen oxide 2. Hydrocarbons in LPG are colourless and odourless. 11. Which of the following chemical is found in dish- Therefore, a strong smelling agent added to LPG washing detergent? cylinders to detect leakage is: (a) Carbon monoxide (b) Chlorine (a) Ethyl mercaptan (b) Nitrous oxide (c) Sulphur dioxide (d) Lithium (c) Hydrogen sulfide (d) Chloroform 12. Proteins help build our body and carbohydrates 3. Chemical irritant produced during chopping an provide energy to the body. The protein and onion (Allium cepa) which makes our eye weepy is: carbohydrate found in milk are: (a) Allinase (b) Sulfoxide (a) Albumin and maltose (b) Pepsin and sucrose (c) Syn-propanethial-S-oxide (d) Allyl mercaptan (c) Collagen and fructose (d) Casein and lactose 4. The powerful anti-inflammatory and antioxidant 13. Salt readily absorbs water from the surroundings. properties of haldi or turmeric (Curcuma longa) are Sprinkling salt on salad releases water from it after due to presence of: few seconds. The process is: (a) Curcumin (b) Gingerol (a) Osmosis (b) Adsorption (c) Cymene (d) Capsaicin (c) Dehydration (d) Oxidation 5. The active ingredient in chilli peppers (Capsicum) 14. Washing hands before eating prevents illness which produces heat and burning sensation in the by killing germs. -
The Sources of Adaptive Variation
Edinburgh Research Explorer The sources of adaptive variation Citation for published version: Charlesworth, D & Barton, N 2017, 'The sources of adaptive variation', Proceedings of the Royal Society B- Biological Sciences, vol. 284, no. 1855. https://doi.org/10.1098/rspb.2016.2864 Digital Object Identifier (DOI): 10.1098/rspb.2016.2864 Link: Link to publication record in Edinburgh Research Explorer Document Version: Peer reviewed version Published In: Proceedings of the Royal Society B-Biological Sciences General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorer content complies with UK legislation. If you believe that the public display of this file breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. Download date: 01. Oct. 2021 1 1 The sources of adaptive variation 2 3 Deborah Charlesworth1, Nicholas H. Barton2, Brian Charlesworth1 4 5 1Institute of Evolutionary Biology, School of Biological Sciences, University of 6 Edinburgh, Charlotte Auerbach Rd., Edinburgh EH9 3FL, UK 7 8 2Institute of Science and Technology Austria, Klosterneuburg 3400, Austria 9 10 Author for correspondence: 11 Brian Charlesworth 12 Email: Brian,[email protected] 13 14 Phone: 0131 650 5751 15 16 Subject Areas: 17 Evolution 18 19 Keywords: 20 21 Modern Synthesis, Extended Evolutionary Synthesis, mutation, natural 22 selection, epigenetic inheritance 23 24 25 26 27 2 28 Abstract 29 The role of natural selection in the evolution of adaptive phenotypes has undergone 30 constant probing by evolutionary biologists, employing both theoretical and empirical 31 approaches. -
CV of Matthew Hartfield ONLINE
Curriculum Vitae Dr Matthew Hartfield Institute of Evolutionary Biology University of Edinburgh, Charlotte Auerbach Road Edinburgh EH9 3FL, UK [email protected] British Citizen EMPLOYMENT 2018 – Present: NERC Independent Research Fellow Institute of Evolutionary Biology, University of Edinburgh, UK 2017 – 2018: Postdoctoral Researcher Bioinformatics Research Centre, Aarhus University, Denmark Supervisor: Dr Thomas Bataillon 2014 – 2017: Marie Curie International Outgoing Fellow Department of Ecology and Evolutionary Biology, University of Toronto, Canada (2014 – 2016): Bioinformatics Research Centre, Aarhus University, Denmark (2016– 2017) Outgoing Hosts: Profs Aneil Agrawal and Stephen Wright Return Host: Dr Thomas Bataillon 2012 – 2014: CNRS Research Fellow ('CDD Chercher') Team MIVEGEC, IRD Montpellier, France Supervisor: Dr Samuel Alizon EDUCATION 2008 – 2012: PhD Evolutionary Biology Institute of Evolutionary Biology, University of Edinburgh, UK Supervisor: Prof. Peter D. Keightley 2007 – 2008: MSc Mathematical Biology University of Bath, UK Degree Class: Pass with Distinction Thesis supervisors: Dr Jane White and Dr Klaus Kurtenbach 2003 – 2007: MSci Mathematics Imperial College of Science, Technology and Medicine, London, UK. Degree Class: First Class (Honours) Page 1 of 5 FUNDING AND SOCIETAL AWARDS Major Awards: 1) NERC Independent Research Fellowship. 5 years (2018 – 2023); £518,440. 2) John Maynard Smith Prize, European Society for Evolutionary Biology. 3) Marie Curie International Outgoing Fellowship. 3 years (2014 – 2017); 271,642.50€. Other Awards: 4) 2018: American Society of Naturalists, towards a visit to the II Joint Congress on Evolutionary Biology (Montpellier, France). $500. 5) 2011: University of Edinburgh’s James Rennie Bequest, towards a visit to ESEB in Tübingen, Germany. £200. 6) 2010: Genetics Society UK, towards a visit to Evolution in Portland OR, USA. -
Lasker Interactive Research Nom'18.Indd
THE 2018 LASKER MEDICAL RESEARCH AWARDS Nomination Packet albert and mary lasker foundation November 1, 2017 Greetings: On behalf of the Albert and Mary Lasker Foundation, I invite you to submit a nomination for the 2018 Lasker Medical Research Awards. Since 1945, the Lasker Awards have recognized the contributions of scientists, physicians, and public citizens who have made major advances in the understanding, diagnosis, treatment, cure, and prevention of disease. The Medical Research Awards will be offered in three categories in 2018: Basic Research, Clinical Research, and Special Achievement. The Lasker Foundation seeks nominations of outstanding scientists; nominations of women and minorities are encouraged. Nominations that have been made in previous years are not automatically reconsidered. Please see the Nomination Requirements section of this booklet for instructions on updating and resubmitting a nomination. The Foundation accepts electronic submissions. For information on submitting an electronic nomination, please visit www.laskerfoundation.org. Lasker Awards often presage future recognition of the Nobel committee, and they have become known popularly as “America’s Nobels.” Eighty-seven Lasker laureates have received the Nobel Prize, including 40 in the last three decades. Additional information on the Awards Program and on Lasker laureates can be found on our website, www.laskerfoundation.org. A distinguished panel of jurors will select the scientists to be honored with Lasker Medical Research Awards. The 2018 Awards will -
Pharmaceutical Science Pharmsci Phd
Pharmaceutical Science PharmSci PhD DISCOVERY | DEVELOPMENT | MANUFACTURING What is Pharmaceutical Science? • Pharmaceutical Sciences is a dynamic and interdisciplinary field that aims to integrate fundamental principles of physical and organic chemistry, engineering, biochemistry, and biology to understand how to optimize delivery of drugs to the body and translate this integrated understanding into new and improved therapies against human disease. • Disciplines of pharmaceutical sciences may include medicinal chemistry, pharmaceutics, pharmacogenetics, pharmacology, biotechnology, pharmacoeconomics, pharmacoepidemiology, pharmacokinetics/clinical pharmacokinetics, clinical pharmacy/ pharmacotherapy, patient safety, regulatory science, health informatics, outcomes, and public health aspects of drug discovery and optimization. pharmacy.umich.edu/pharmsci aacp.org/resource/graduate-degrees-defined Career Options with a Pharmaceutical Science Degree • Research and Development: Scientists, Senior Scientists, Principal Scientist. (It’s likely a specialization will be mentioned in the title — e.g., pharmacology, neuroscience, oncology) • Regulatory Affairs: Regulatory Affairs Specialist, Regulatory Affairs Officer • Clinical Trials: Clinical Scientists, Clinical Research Associate • Business Development: Business Development Manager • Sales and Marketing: Medical Sales Representative, Account Manager, Product Manager, Brand Manager mendeley.com/careers/article/what-are-the-career-options-for-a-phd-in-the-pharmaceutical-industry-/ Common Pharmaceutical -
Recent Winners of the Nobel Medicine Prize 1 October 2018
Recent winners of the Nobel Medicine Prize 1 October 2018 2015: William Campbell (US citizen born in Ireland) and Satoshi Omura (Japan), Tu Youyou (China) for unlocking treatments for malaria and roundworm. 2014: John O'Keefe (Britain, US), Edvard I. Moser and May-Britt Moser (Norway) for discovering how the brain navigates with an "inner GPS". 2013: Thomas C. Suedhof (US citizen born in Germany), James E. Rothman and Randy W. Schekman (US) for work on how the cell organises its transport system. 2012: Shinya Yamanaka (Japan) and John B. Gurdon (Britain) for discoveries showing how adult cells can be transformed back into stem cells. 2011: Bruce Beutler (US), Jules Hoffmann (French citizen born in Luxembourg) and Ralph Steinman (Canada) for work on the body's immune system. Credit: Wikipedia 2010: Robert G. Edwards (Britain) for the development of in-vitro fertilisation. 2009: Elizabeth Blackburn (Australia-US), Carol Here is a list of the winners of the Nobel Medicine Greider and Jack Szostak (US) for discovering how Prize in the past 10 years, after James Allison of chromosomes are protected by telomeres, a key the US and Tasuku Honjo of Japan were awarded factor in the ageing process. Monday for research that has revolutionised cancer treatment: © 2018 AFP 2018: Immunologists Allison and Honjo win for figuring out how to release the immune system's brakes to allow it to attack cancer cells more efficiently. 2017: US geneticists Jeffrey Hall, Michael Rosbash and Michael Young for their discoveries on the internal biological clock that governs the wake- sleep cycles of most living things. -
Potential and Mentality of Genius and Inspiration and Milestone
Crimson Publishers Research Article Wings to the Research Potential and Mentality of Genius and inspiration and milestone breakthroughs: longevity, diseases and Beyond Yue Zhang1,2,3* 1Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China 2Nobel Breakthroughs Inspiration Milestone Initiative, Pinghu Hospital of Shenzhen University, China 3Department of Rheumatology and Immunology, The First Clinical College of Harbin Medical University, China Abstract relatedThis diseases conceptual and beyond. study focusesIt aims to on help the promote evolving government field of potential strategy, andfostering the mentalityapprenticeships, of genius, and renewinginspiration ideas and aboutmilestone the role breakthroughs of family, hardship, alongside war, lines paradigm of stories shifts of andscientific religion life in of, developing longevity, geniusaging- and inspiration that will help make more groundbreaking discoveries in China. First, this essay reviews some of the factors that help stimulate, develop and inspire the leading scientists and researchers of the future. It then turns to some examples of inspired genius, before turning to my personal journey into the world of scientific research of longevity, aging-related diseases (e.g. *Corresponding author: Yue Zhang, some conclusions about how to inspire the prizewinning scientists of tomorrow’ China, even the world. Shenzhen Futian Hospital for Rheumatic Alzheimer’s diseases, Huntington’s diseases, cancer, Osteoarthritis (OA)) and beyond. We finish with Diseases, Shenzhen, #22 Nonglin road, China. Emai: [email protected] Factors Fostering Genius and Inspiration Numerous factors appear to be important in developing the brilliant scientists who make Submission: March 31, 2020 breakthrough discoveries. Here, we give only a brief review of each for reasons of space, as Published: April 22, 2020 large amounts of literature could be written on each one. -
The Outstanding Scientist, R.A. Fisher: His Views on Eugenics and Race
Heredity (2021) 126:565–576 https://doi.org/10.1038/s41437-020-00394-6 PERSPECTIVE The outstanding scientist, R.A. Fisher: his views on eugenics and race 1 2 3 4 5 Walter Bodmer ● R. A. Bailey ● Brian Charlesworth ● Adam Eyre-Walker ● Vernon Farewell ● 6 7 Andrew Mead ● Stephen Senn Received: 2 October 2020 / Revised: 2 December 2020 / Accepted: 2 December 2020 / Published online: 15 January 2021 © The Author(s) 2021. This article is published with open access Introduction aim of this paper is to conduct a careful analysis of his own writings in these areas. Our purpose is neither to defend nor R.A. Fisher was one of the greatest scientists of the 20th attack Fisher’s work in eugenics and views on race, but to century (Fig. 1). He was a man of extraordinary ability and present a careful account of their substance and nature. originality whose scientific contributions ranged over a very wide area of science, from biology through statistics to ideas on continental drift, and whose work has had a huge Fisher’s scientific achievements 1234567890();,: 1234567890();,: positive impact on human welfare. Not surprisingly, some of his large volume of work is not widely used or accepted Contributions to statistics at the current time, but his scientific brilliance has never been challenged. He was from an early age a supporter of Fisher has been described as “the founder of modern sta- certain eugenic ideas, and it is for this reason that he has tistics” (Rao 1992). His work did much to enlarge, and then been accused of being a racist and an advocate of forced set the boundaries of, the subject of statistics and to estab- sterilisation (Evans 2020).