Sodium Ascorbate

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SODIUM ASCORBATE Prepared at the 17th JECFA (1973), published in FNP 4 (1978) and in FNP 52 (1992). Metals and arsenic specifications revised at the 61st JECFA (2003). A group ADI ‘not specified’ was established for ascorbic acid and its Ca, K and Na salts at the 25th JECFA (1981). SYNONYMS INS No. 301 DEFINITION Chemical names Sodium ascorbate, sodium L-ascorbate, 2,3-didehydro-L-threo-hexono-1,4- lactone sodium enolate; 3-keto-L-gulofurano-lactone sodium enolate C.A.S. number 134-03-2 Chemical formula C6H7O6Na Structural formula Formula weight 198.11 Assay White or almost white, odourless crystalline powder which darkens on exposure to light DESCRIPTION Not less than 99% after drying FUNCTIONAL USES Antioxidant CHARACTERISTICS IDENTIFICATION Solubility (Vol. 4) Freely soluble in water; very slightly soluble in ethanol See description under TESTS Test for ascorbate Passes test Vol. 4) Test for sodium (Vol. 4) Passes test Test a solution of previously ignited sample, acidified with dilute acetic acid TS, filtered if necessary Reducing reaction A solution of the sample will decolourize a solution of 2,6-dichloro- phenolindophenol TS PURITY Loss on drying (Vol. 4) Not more than 0.25% (vacuum desiccator over sulfuric acid, 24 h) pH (Vol. 4) 6.5 - 8.0 (1 in 10 soln) Specific rotation (Vol. 4) [alpha] 25,D: Between +103o and +108o (10% (w/v) aqueous solution) Lead (Vol. 4) Not more than 2 mg/kg Determine using an atomic absorption technique appropriate to the specified level. The selection of sample size and method of sample preparation may be based on the principles of the method described in Volume 4, “Instrumental Methods.” METHOD OF Dissolve about 0.400 g of the dried sample in a mixture of 100 ml of carbon ASSAY dioxide-free water and 25 ml of dilute sulphuric acid TS. Titrate the solution at once with 0.1 N iodine, adding a few drops of starch TS as indicator as the end-point is approached. Each ml of 0.1 N iodine is equivalent to 9.905 mg of C6H7O6Na. .

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Sodium Ascorbate Powder USP MSDS Material Safety Data Sheet
Sodium Ascorbate Powder USP MSDS Material Safety Data Sheet NFPA HMIS Personal Protective Equipment Health Hazard 1 1 1 0 Fire Hazard 1 Reactivity 0 See Section 15. Section 1. Chemical Product and Company Identification Page Number: 1 Common Name/ Sodium ascorbate Catalog S1137, SO108, S1349 Trade Name Number(s). CAS# 134-03-2 Manufacturer SPECTRUM LABORATORY PRODUCTS INC. RTECS CI7671000 14422 S. SAN PEDRO STREET TSCA TSCA 8(b) inventory: Sodium GARDENA, CA 90248 ascorbate Commercial Name(s) Ascorbicin, Ascorbin, Cebitate, Natrascorb CI# Not available. Synonym Sodium L-Ascorbate; Vitamin C Sodium; IN CASE OF EMERGENCY L-Ascorbic acid sodium salt; CHEMTREC (24hr) 800-424-9300 Ascorbic acid sodium salt; Monosodium L-Ascorbate Chemical Name L-Ascorbic Acid, monsodium salt Chemical Family Not available. CALL (310) 516-8000 Chemical Formula C6H7NaO6 Supplier SPECTRUM LABORATORY PRODUCTS INC. 14422 S. SAN PEDRO STREET GARDENA, CA 90248 Section 2.Composition and Information on Ingredients Exposure Limits Name CAS # TWA (mg/m 3) STEL (mg/m 3) CEIL (mg/m 3) % by Weight 1) Sodium ascorbate 134-03-2 100 Toxicological Data Sodium ascorbate : on Ingredients ORAL (LD50): Acute: 17531 mg/kg [Mouse]. 16300 mg/kg [Rat]. Section 3. Hazards Identification Potential Acute Health Effects Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Potential Chronic Health CARCINOGENIC EFFECTS : Not available. Effects MUTAGENIC EFFECTS : Mutagenic for mammalian somatic cells. TERATOGENIC EFFECTS : Not available. DEVELOPMENTAL TOXICITY : Not available. The substance may be toxic to kidneys, bladder. Repeated or prolonged exposure to the substance can produce target organs damage.
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Scientific Documentation S1349, Sodium Ascorbate, Powder, USP Not appropriate for regulatory submission. Please visit www.spectrumchemical.com or contact Tech Services for the most up‐to‐date information contained in this information package. Spectrum Chemical Mfg Corp 769 Jersey Avenue New Brunswick, NJ 08901 Phone 732.214.1300 Ver4.02 23.May.2016 Dear Customer, Thank you for your interest in Spectrum’s quality products and services. Spectrum has been proudly serving our scientific community for over 45 years. It is our mission to manufacture and distribute fine chemicals and laboratory products with Quality and delivery you can count on every time. To accomplish our mission, Spectrum utilizes our sourcing leverage and supplier qualification expertise in offering one of the industry’s most comprehensive line of fine chemical products under one brand, in packaging configurations designed to meet your research and production requirements. Our product grades include: USP, NF, BP, EP, JP, FCC, ACS, KSA, Reagent grade, as well as DEA controlled substances. We operate facilities in the United States on the East Coast, West Coast, as well as in Shanghai, China in order to provide the best logistical support for our customers. At Spectrum, Quality is priority number one. Suppliers with the best qualifications are preferred and we employ full-functioning in-house analytical laboratories at each of our facilities. Our facilities and systems are USFDA registered and ISO certified. We frequently host customer audits and cherish opportunities for improvements. Quality is engrained into our culture. Quality is priority number one. In the following pages, we have designed and prepared documented scientific information to aid you in your initial qualification or your continual use of our products.
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And Calcium Ascorbate (E 302) As Food Additives1
EFSA Journal 2015;13(5):4087 SCIENTIFIC OPINION Scientific Opinion on the re-evaluation of ascorbic acid (E 300), sodium ascorbate (E 301) and calcium ascorbate (E 302) as food additives1 EFSA Panel on Food additives and Nutrient Sources added to Food (ANS)2,3 European Food Safety Authority (EFSA), Parma, Italy ABSTRACT The EFSA Panel on Food additives and Nutrient Sources added to Food (ANS Panel) provides a scientific opinion re-evaluating the safety of ascorbic acid (E 300), sodium ascorbate (E 301) and calcium ascorbate (E 302) as food additives. The use of ascorbic acid and its salts as food additives was evaluated by the Joint FAO/WHO Expert Committee on Food Additives and by the Scientific Committee on Food. Ascorbic acid is absorbed from the intestine by a sodium-dependent active transport process and, at low doses, the absorption is almost complete until a saturation point, after which increasing amounts of unabsorbed substance are excreted. Ascorbic acid and its salts have very low acute toxicities, and short-term tests in animals showed little effect, and even so only at high doses. The Panel concluded that there is no genotoxicity concern for ascorbic acid, sodium ascorbate or calcium ascorbate. Long-term carcinogenicity tests with ascorbic acid did not show any chronic toxicity, even at high doses, and also showed no signs of carcinogenicity. Prenatal developmental studies did not show adverse developmental effects. The Panel estimated the combined exposure to ascorbic acid (E 300), calcium ascorbate (E 301) and sodium ascorbate (E 302). The Panel concluded that, given the fact that adequate data on exposure and toxicity were available and no adverse effects were reported in animal studies, there is no safety concern for the use of ascorbic acid (E 300), sodium ascorbate (E 301) and calcium ascorbate (E 302) as food additives at the reported uses and use levels and there is no need for a numerical ADI for ascorbic acid and its salts.
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Safety Data Sheet
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Safety Data Sheet
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