Subject Index to Volume 73 JANUARY-DE(MEMBER 1976

Introduction The terms in the Subject Index for Vol ume 73, January-December 1976, of the PROCEEDINGSOF THE NATIONALACA DEMY OF SCIENCESUSA were chosen mainly from titles and key terms of artic] es. The index terms are alphabetized by computer; numbers, conformational pref ixes, Greek letters, hyphens, and spaces between words are disregarded in alphabe tization. After each index term is printed the title of the article (or a suitable modi fication of the title) and the appropriate page number. Titles are listed in alphabe tical order under the index terms. Classifications (e.g., Physics, Mather latics) under which papers have been published are used as index terms only if it seemed this would be helpful. Papers that are concerned in some major way with methodology are indexed under "Methodology" as well as under more sj ,ecific terms. Papers relevant to human diseases are indexed under "Diseases of I iuman beings" (with some subclassifica- tions) as well as under more specific tern is. Corrections to papers in which errors occurred are indexed under the term "Coi rection" as well as under the index terms selected for the paper itself. Organisms are indexed by their scientific names when scientific names were provided in the pape rs; suitable cross-references are provided. Genes are listed together as, for example ,"Gene, lac." Because the PROCEEDINGSurges auth ors to follow the tentative rules and rec- ommendations of the nomenclature cor amissions (e.g., for biochemistry, those proposed by the International Union ol 'Pure and Applied Chemistry and the Commission on Biochemical Nomenclatu re), an effort has been made to construct an index that conforms with this policy. However, correction of errors in nomen- clature was not attempted and the index should not be looked upon as a reference for correct or recommended usage. In a ddition, some exceptions to the recom- mendations of the commissions were nece:isary. Index terms themselves are usually not abbreviated even if specific recomm endations have been made by the com- missions; and in some instances, words wit]iin an index term were rearranged. (Thus, tRNA is indexed as "Ribonucleic acid, t ransfer.") In general, analogues of com- pounds are indexed as the parent compou]id. (Thus, dibutyryl adenosine 3:5-cyclic monophosphate is indexed as "Adenosine 3':5'-cyclic monophosphate, dibutyryl-.") The "Recommended Name" from the 19' '2 recommendations of the International Union of Pure and Applied Chemistry anc Ithe International Union of Biochemistry [Enzyme Nomenclature (1973), America n Elsevier, New York] has been used for enzymes whenever Enzyme Commission (EC) numbers were published in the pa- pers, since the 1972 recommendations were followed by the editorial staff throughout 1976. EC numbers are listed a s part of the entry only if the EC number was printed in the paper. [Thus, some ei lzymes have two entries, e.g., "Adenosi- netriphosphatase" and "Adenosinetriph( )sphatase (EC 3.6.1.3)."]

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PAGINATION 0 F ISSUES

Pages Issue Month Pages Issue Month Pages Issue Month

1-268 1 January 1377-1772 5 May 2945-3324 9 September 269-664 2 February 1773-2168 6 June 3325-3784 10 October 665-980 3 March 2169-2532 7 July 3785-4252 11 November 981-1376 4 April 2533-2944 8 August 4253-4792 12 December

Abelian phase group Myosin-paramyosin cofilaments: Enzymatic interactions with F-actin, Relativized problems with abelian phase group in topological dynamics, 3015 1007 Actin filament Acetabularia mediterranea Polarity of actin filaments in Characean algae, 165 Temperature dependence of cycloheximide-sensitive phase.of circadian Actin-like filament cycle in Acetabularia mediterranea, 3216 Actin-like filaments and membrane rearrangement in oxyntic cells, 4032 Acetic anhydride Actinomycin D Activation of chromatin by acetylation of side chains, 3937 Biphasic stimulation of polyamine biosynthesis in primary mouse kidney Acetobacter xylinum cells by infection with polyoma virus: Uncoupling from DNA and Cellulose biosynthesis in Acetobacter xylinum: Visualization of site of rRNA synthesis, 4022 synthesis and direct measurement of in vivo process, 4565 Messenger RNA competition in shutoff of human interferon production, N-Acetoxy-2-acetylaminofluorene 1621 Synthesis of nuclear during DNA repair synthesis in human Synthesis of murine leukemia virus proteins associated with virions diploid fibroblasts damaged with ultraviolet radiation or assembled in actinomycin D-treated cells: Persistence of viral N-acetoxy-2-acetylaminofluorene, 1466 messenger RNA, 1154 Acetylation Translational control in regulation of ferritin synthesis by iron, 857 Activation of chromatin by acetylation of histone side chains, 3937 Action potential Acetylcholine Membrane potential dependent binding of scorpion toxin to action see also , acetylcholine; Receptor, nicotinic acetylcholine potential Na+ ionophore, 2682 Acetylcholine receptors: Localization during synaptogenesis in retina, Spike-forming model of neural membrane: Computer simulation of 1806 additional perfused axon experiments, 100 Choline synthesized from ethanolamine in rat brain, 2181 Spike-forming model of neural membrane: Improvement in parameter Isolated acetylcholine receptor : Kinetics of binding of values, 2264 acetylcholine and Ca ions, 3994 Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells, 2520 Mechanism of action of (-bungarotoxin on synaptosomal preparations, Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells 2664 (correction), 4247 Photoaffinity labeling and quaternary structure of acetylcholine receptor Actomyosin from Torpedo californica, 2624 Myosin-mediated Ca++-regulation of Synapse and acetylcholine receptor synthesis by neurons dissociated actomyosin-adenosinetriphosphatase from porcine aorta, 2706 from retina, 2370 Acyl-acyl carrier protein synthetase Synapse formation between clonal neuroblastoma X glioma hybrid cells Activation of long chain fatty acids with acyl carrier protein: New and striated muscle cells, 123 enzyme, acyl-acyl carrier protein synthetase, in , 4374 Synthesis of acetylcholine receptors by cultured chick myotubes and Acyl carrier protein denervated mouse extensor digitorum longus muscles, 161 Activation of long chain fatty acids with acyl carrier protein: New Transduction of chemical into electrical energy, 82 enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli, 4374 Acetylcholinesterase (EC 3.1.1.7) Acyl-coenzyme A synthetase (EC 6.2.1.3) Effect, of p'prQis+ent "elective suppression of ganglionic Acyl coenzyme A synthetase activity is required for repression of yeast :.?': \i t.' I. li'lln.-t'-', on steady state and regenerating levels of acetyl coenzyme A carboxylase by exogenous fatty acids, 386 acetylcholinesterase: Function of butyrylcholinesterase and regulation Adaptation of protein synthesis, 2936 Rates, patterns, and effectiveness of evolution in multi-level situations, Acetyl-coenzyme A carboxylase (EC 6.4.1.2) 1360 Acyl coenzyme A synthetase activity is required for repression of yeast Sherpas living permanently at high altitude: Pattern of adaptation, 747 acetyl coenzyme A carboxylase by exogenous fatty acids, 386 Addendum Dietary and hormonal regulation of content of acetyl coenzyme A Porphyria variegata and porphyria cutanea tarda in siblings: Chemical carboxylase-synthesizing polysomes in rat liver, 2304 and genetic aspects (Addendum), 1323 N-Acetylglucosamine Purification of folate binding factor in normal umbilical cord serum Prediction of three-dimensional structures of enzyme-substrate and (Addendum) 2527 enzyme-inhibitor complexes of lysozyme, 4261 Adenine 1--N-Acetylglucosaminidase (EC 3.2.1.30) Ultraviolet photoelectron studies of biological purines: Valence electronic Heteropolymeric hexosaminidase A in human X mouse hybrid cells, 3637 structure of adenine, 2966 Interrelationship of hexosaminidases A and B: Confirmation of common Adenine analog and unique subunit theory, 2833 Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity Specific recognition sites mediating clearance of lysosomal enzymes in and cholesterol synthesis in nonhepatic tissues of rat, 2564 uiuvo, 4045 Adenine, methyl-substituted Acrasin Hormonal control of meiosis: Specificity of 1-methyladenine receptors in Acrasin of cellular slime mold Polysphondylium violaceum, 795 starfish oocytes, 1669 Acrasinase Ultraviolet photoelectron studies of biological purines: Valence electronic Acrasin of cellular slime mold Polysphondylium violaceum, 795 structure of adenine, 2966 Actin Adenine nucleotide Asynchronous synthesis of erythrocyte membrane proteins, 3206 see also specific adenosine nucleoside phosphates A'I'l bitnding to protease-resistant core of actin, 2742 Diadenosine 5',5`'-P1,P4-.tetraphosphate (Ap4A) in mammalian cells in Calcium control of actin-activated myosin adenosine triphosphatase from levels varying widely with proliferative activity of tissue: Possible Dictyostelium discoideum, 2321 positive "pleiotypic activator", 3984 Chick cytoplasmic actin and muscle actin have different structural genes, Incorporation of adenosine into ATP: Formation of compartmentalized 2346 ATP, 3122 Free energy levels and entropy production in muscle contraction and in Adenocarcinoma related solution systems, 336 Immunological crossreactivity of antibodies to synthetic undecapeptide Free energy levels and entropy production in muscle contraction and in analogous to amino-terminal segment of carcinoembryonic antigen, related solution systems (correction), 2165 with intact protein and with human sera, 2123 Immunological characterization of subunit of 100 A filaments from Adenosine 3':5'-cyclic monophosphate muscle cells, 4344 see also Cyclic nucleotide metabolism Microfilament organization and surface topography: Changes upon Cross inhibitory interactions of potential mediators of hormone and transformation of chick embryo fibroblasts with Rous sarcoma virus, neurotransmitter action, 2982 4065 Adenosine 3':5'-cyclic monophosphate binding protein Protein synthesis and actin heterogeneity in calf muscle cells in culture, Radioimmunoassay of bovine heart protein kinase, 54 2018 Adenosine 3':5'-cyclic monophosphate, dibutyryl- Reciprocal reactivities of specific thiols when actin binds to myosin, 302 Phenotypic transformation of clonal myogenic cells to cells resembling Reconstitution of intramembrane particles in recombinants of chondrocytes, 1989 erythrocyte protein Band 3 and lipid: Effects of spectrin-actin Adenosine 3':5'-cyclic monophosphate in animal cells association, 3891 Abnormal levels of 3':5'-cyclic AMP in isoproterenol-stimulated Actin, F- fibroblasts from patients with cystic fibrosis, 2899 Affinity of myosin S-1 for F-actin, measured by time-resolved Activation and nuclear translocation of protein kinase during fluorescence anisotropy, 133 transsynaptic induction of tyrosine 3-monooxygenase, 1058 Affinity of myosin S-1 for F-actin, measured by time-resolved Activation of 3':5'-cyclic AMP-dependent protein kinase and induction fluorescence anisotropy (correction), 2527 of ornithine decarboxylase as early events in induction of mixed-function oxygenases, 1241 Downloaded by guest on October 5, 2021 Proc. 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Ca2+and adenylateand guanylatecyclases in controlof platelet Adenosinetriphosphatase(EC 3.6.1.3) secretionand aggregation,1829 ATP bindingto protease-resistantcore of actin, 2742 Catecholamine-stimulatedcyclic GMP accumulationin rat pineal: Calciumcontrol of actin-activatedmyosin adenosinetriphosphatase from Apparentpresynaptic site of action, 3398 Dictyosteliumdiscoideum, 2321 Cellularcyclic nucleotidesand enzymesecretion in pancreaticacinar cell, Neurosporaplasma membrane ATPase is an electrogenicpump, 1485 156 Restorationof oxidativephosphorylation by purified Couplingof catecholaminereceptor from one cell with adenylatecyclase N,N'-dicyclohexylcarbodiimide-sensitivelatent from anothercell by cell fusion, 4410 adenosinetriphosphatasefrom Mycobacteriumphlei, 3050 Cyclic nucleotidemetabolism in compensatoryrenal hypertrophyand Adenosine5'-triphosphate neonatalkidney growth, 524 ATP bindingto protease-resistantcore of actin, 2742 Distributionof 3':5'-cyclicAMP and 3':5'-cyclicGMP in rabbitretina in ATP-PPi exchangeactivity of progesteronereceptor, 3443 vivo:Effects of dark and light adaptationand ischemia,4442 Incorporationof adenosineinto ATP: Formationof compartmentalized Effect of 3':5'-cyclicAMP on glucosetransport in rat adipocytes,4359 ATP, 3122 Effects of choleratoxin on cochlearendolymph production: Model for Neurosporaplasma membrane ATPase is an electrogenicpump, 1485 endolymphatichydrops, 1761 Transitorytight bindingof ATP and of committedPi and ADP during Guanosine3':5'-cyclic monophosphate binding proteins in rat tissues, ATP synthesis by chloroplasts, 4314 2559 Adenosine5'-triphosphate analog Hepatic phenylalanine4-monooxygenase is a phosphoprotein,1591 Stereochemistryof polymerizationby DNA-dependentRNA polymerase Hormonalcontrol of pyruvatekinase activity and of gluconeogenesisin from Escherichiacoli: Use of diastereomericATP-analogue, 2987 isolated hepatocytes,2762 S-Adenosylhomocysteine Intraneuronalguanylyl-imidodiphosphate injection mimics long-term RibonucleaseH of calf thymus:Substrate specificity, activation, synaptichyperpolarization in Aplysia, 4689 inhibition,1087 Protein synthesis in reticulocytelysates: Effects of 3':5'-cyclicAMP, S-Adenosylmethionine ATP, and GTP on inhibitionsinduced by heme-deficiency, RibonucleaseH of calf thymus:Substrate specificity, activation, double-strandedRNA, and a reticulocytetranslational inhibitor, 1112 inhibition,1087 Protein synthesis in reticulocytelysates: Phosphorylation of S-Adenosylmethioninecleaving enzyme methionyl-tRNAfbinding factor by proteinkinase activity of BacteriophageT3 and T7 early RNAs are translatedby eukaryotic80S translationalinhibitor isolated from heme-deficientlysates, 3112 :Active phage T3 coded S-adenosylmethioninecleaving Radioimmunoassayof bovineheart protein kinase, 54 enzyme is synthesized,2752 Regulationof dopaminestimulation of striatal adenylatecyclase by an S-Adenosylmethioninedecarboxylase (EC 4.1.1.50) endogenousCa+4-binding protein, 3887 Biphasicstimulation of polyaminebiosynthesis in primarymouse kidney Steroid hormonesregulate phosphorylation of specific proteincommon cells by infectionwith polyomavirus: Uncoupling from DNA and to severaltarget organs,568 rRNAsynthesis, 4022 Synthetic hexapeptidesubstrates and inhibitorsof 3':5'-cyclic S-Adenosyl-L-methionine:tRNAmethyltransferase AMP-dependentprotein kinase, 1038 Subcellularlocalization of S-adenosyl-L-methionine:tRNA Transsynapticallyelicited increaseof 3':5'-cyclicAMP regulatedby methyltransferaseswith aminoacyl-tRNAsynthetases in humanand endogenousphosphodiesterase activator, 352 mouse:Normal and leukemicleukocytes, 3857 Tubulin synthesis in islets of Langerhans,3188 Adenovirus Adenosine3':5'-cyclic monophosphate in culturedanimal cells DNA methylationin adenovirus,adenovirus-transformed cells, and host Adenylatecyclase activity in LM cells by modifiedmanipulation of cells, 3923 membranephospholipid composition in vivo, 4482 Do highly oncogenicgroup A humanadenoviruses cause humancancer? Cell surfaceprotein partially restores morphology, adhesiveness, and Analysisof humantumors for adenovirus12 transformingDNA contact inhibitionof movementto transformedfibroblasts, 1217 sequences,4657 Conversionof 3T3 fibroblastsinto adipose cells:Triggering of Intracellularforms of adenovirusDNA: Integratedform of adenovirus differentiationby prostaglandinF2, and 1-methyl-3-isobutylxanthine, DNA appearsearly in productiveinfection, 1043 4516 Simianvirus 40 tumor-specificproteins in nucleus and plasma Culturedtumor cells: Affinity isolationby drugsand hormones membraneof HeLa cells infected by adenovirus2-SV40 hybridvirus covalentlybound to glass and Sepharosebeads, 2013 Ad2+ND2,2505 Effects of concanavalinA and succinylatedderivative on lymphocyte Tumorinduction and large externaltransformation sensitive proteinon proliferationand cyclic nucleotidelevels, 1717 cell surface,3570 Functionalincorporation of gangliosideinto intact cells: Inductionof Adenovirus-associatedvirus choleragenresponsiveness, 1034 Concatemersof alternatingplus and minus strandsare intermediatesin Hormoneand neurotransmitterreceptors in establishedvascular adenovirus-associatedvirus DNA synthesis, 742 endothelialcell line, 1612 Adenoviruschromosome Inductionand decay of glucagon-inducedamino acid transportin Chromatin-likeorganization of adenoviruschromosome, 401 primarycultures of adult rat liver cells: Paradoxicaleffects of Adenylatecyclase cycloheximideand puromycin,4511 Choleragen-mediatedrelease of trappedglucose from liposomes Maturationof neuroblastomacells in presenceof dimethylsulfoxide,462 containingganglioside GM1, 3480 Relationshipof gangliosidesto structureand function of thyrotropin Desensitizationof 3-adrenergicreceptors by ,-adrenergic agonistsin receptors:Their absenceon plasmamembranes of thyroidtumor cell-freesystem: Resensitization by guanosine defective in thyrotropinreceptor activity, 4060 5'-(Of,-y-imino)triphosphateand other purinenucleotides, 1494 Adenosine3':5'-cyclic monophosphate in microorganisms Hydrolysisof nicotinamideadenine dinucleotide by choleragenand its A Adenosine3':5'-cyclic monophosphate deficiency in Neurosporacrassa, protomer:Role in activationof adenylatecyclase, 4424 2995 Regulationof guanylateand adenylatecyclase activities by lysolecithin, Catabolitemodulator factor: Mediator of cataboliterepression in 1586 bacteria,3476 Relationshipof gangliosidesto structureand functionof thyrotropin 3':5'-CyclicGMP derivatives:Effect on formationof Caulobactersurface receptors:Their absenceon plasmamembranes of thyroidtumor structures,3303 defective in thyrotropinreceptor activity, 4060 Differentiationstimulating factor inducescell sensitivity to 3':5'-cyclic Adenylatecyclase (EC 4.6.1.1) AMP pulses in Dictyosteliumdiscoideum, 1250 Adenosine3':5'-cyclic monophosphate deficiency in Neurosporacrassa, Extracytoplasmicadenylate cyclase of Bordetellapertussis, 1926 2995 Inhibitionand stimulationof developmentof bioluminescentsystem in Adenylatecyclase activity in LM cells by modifiedmanipulation of Beneckeaharveyi by cyclic GMP, 4454 membranephospholipid composition in vivo, 4482 Sugarsaffect early biochemicalevents in developmentof Dictyostelium Adenylatecyclase from secretoryvesicle membranescontrolled by discoideum,3183 ,3-adrenergicagents and nerve growthfactor, 771 Adenosine3':5'-cyclic monophosphate phosphodiesterase (EC 3.1.4.17) /3-Adrenergicreceptors in rat liver:Effects of adrenalectomy,1343 Transsynapticallyelicited increaseof 3':5'-cyclicAMP regulatedby Affinity label for ,f-adrenergicreceptor in turkeyerythrocytes, 1921 endogenousphosphodiesterase activator, 352 Ca2+and adenylateand guanylatecyclases in control of platelet Adenosinedeaminase (EC 3.5.4.4) secretionand aggregation,1829 Normallevel of adenosinedeaminase activity in red cell lysates of Choleratoxin interactionswith thyrotropinreceptors on thyroidplasma carriersand patients with severe combinedimmunodeficiency disease, membranes,1679 104 Couplingof catecholaminereceptor from one cell with adenylatecyclase Purine metabolismin adenosinedeaminase deficiency, 2867 from anothercell by cell fusion, 4410 Residualenzyme activity in fibroblastsfrom patients with adenosine Culturedtumor cells: Affinity isolation by drugsand hormones deaminasedeficiency and combinedimmunodeficiency: Evidence for covalentlybound to glass and Sepharosebeads, 2013 mutant enzyme, 213 Distributionof calcitonin-sensitiveadenylate cyclase activity along Adenosine 5'-diphosphate ribosylation rabbitkidney tubule, 3608 Amino-acid sequence of Fragment A, enzymically active fragment from Effects of choleratoxin on cochlearendolymph production: Model for diphtheria toxin, 69 endolymphatichydrops, 1761 Adenosine 5'-monophosphate, 1,N6.etheno- Extracytoplasmicadenylate cyclase of Bordetellapertussis, 1926 l,Ne-Etheno-AMP and l,N6-etheno-2'-deoxy-AMP as probes of activator Functionalincorporation of gangliosideinto intact cells: Inductionof site of glycogen phosphorylase from rabbit skeletal muscle, 2696 choleragenresponsiveness, 1034 Adenosinetriphosphatase Intraneuronalguanylyl-imidodiphosphate injection mimics long-term Elimination of rotating carrier mechanism for active transport of Ca ion synaptichyperpolarization in Aplysia, 4689 in sarcoplasmic reticulum membranes, 1532 Model for hormone-activatedadenylate cyclase systems, 1189 Myosin-mediated Ca++-regulaton of Regulationof dopaminestimulation of striatal adenylatecyclase by an actomyosin-adenosinetriphosphatase from porcine aorta, 2706 endogenousCa++-binding protein, 3887 Downloaded by guest on October 5, 2021 4718 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Small fragments from A subunit of cholera toxin capable of activating Albumin adenylate cyclase, 2654 Covalent attachment of metal chelates to proteins: Stability in vivo and Tolerance and dependence evoked by endogenous opiate peptide, 3165 in vitro of conjugate of albumin with chelate of lllindium, 3803 Adipocyte Immunological crossreaction between alpha-fetoprotein and albumin, Ability of insulin to increase calcium binding by adipocyte plasma 4641 membranes, 1542 Alcohol dehydrogenase (EC 1.1.1.1) Effect of 3':5'-cyclic AMP on glucose transport in rat adipocytes, 4359 Chemical reactivities of catalytic and noncatalytic zinc or cobalt atoms of Adipose tissue horse liver alcohol dehydrogenase: Differentiation by thermodynamic Effect of 3':5'-cyclic AMP on glucose transport in rat adipocytes, 4359 and kinetic properties, 344 Adjuvant Regulation of expression of Adh genes in maize, 582 Immune response modulated by synthetic adjuvant and analogs, 2472 Alcoholism Admissible convergence Type I and type III collagens increased in human alcoholic liver Maximal functions: Poisson integrals on symmetric spaces, 2547 cirrhosis, 539 Adrenalectomy Algebraic K-theory gl-Adrenergic receptors in rat liver: Effects of adrenalectomy, 1343 High dimensional cohomology of discrete groups, 1795 Adrenal gland Algebra, separable C*- Adrenal cholesterol uptake from plasma lipoproteins: Regulation by Lifting derivations from quotients of separable C*-algebras, 1414 corticotropin, 4329 Algebras, Milnor Adrenal medulla Bernstein polynomials and Milnor algebras, 2546 Activation and nuclear translocation of protein kinase during Algorithm transsynaptic induction of tyrosine 3-monooxygenase, 1058 Computing the Discrete Fourier Transform, 1005 Clathrin: Protein associated with intracellular transfer of membrane by Alkaline phosphatase (EC 3.1.3.1) coated vesicles, 1255 Alkaline phosphatase activity in lymphocyte, mitogen-induced blasts, Subcellular distribution of protein carboxymethylase and its endogenous lymphoblastoid cell lines, acute myeloid leukemia, and chronic substrates in adrenal medulla: Role in excitation-secretion coupling, lymphatic leukemia cells, 1432 4050 Extracytoplasmic adenylate cyclase of Bordetella pertussis, 1926 Adrenergic Growth of transplanted tails of infant rats in adolescent allogeneic see also Epinephrine; Receptor, a-adrenergic; Receptor, /-adrenergic recipients, 3283 fi-Adrenergic agent Human liver and placental alkaline phosphatase isoenzymes are coded Adenylate cyclase from secretory vesicle membranes controlled by by different genes, 2201 /-adrenergic agents and nerve growth factor, 771 Structure at 5'-ends of nascent DNA chains, 3438 fi-Adrenergic agonist Alkaline phosphatase, N- Abnormal levels of 3':5'-cyclic AMP in isoproterenol-stimulated Alkaline phosphatase activity in lymphocyte, mitogen-induced blasts, fibroblasts from patients with cystic fibrosis, 2899 lymphoblastoid cell lines, acute myeloid leukemia, and chronic Desensitization of (-adrenergic receptors by (-adrenergic agonists in lymphatic leukemia cells, 1432 cell-free system: Resensitization by guanosine Allantoic fluid 5'-(3,-y-imino)triphosphate and other purine nucleotides, 1494 RNA-dependent DNA polymerase, different from known viral reverse Adrenergic nervous system transcriptases, in chicken system, 3025 Triiodothyronine localized in nerve ending fractions of rat brain, 941 Allele frequency Adrenergic synapse Infinite allele model with varying mutation rate, 4164 Rat sympathetic neurons and cardiac myocytes developing in Allelic heterogeneity microcultures: Correlation of fine structure of endings with Allelic heterogeneity within allozymes separated by electrophoresis in neurotransmitter function in single neurons, 4220 Drosophila pseudoobscura, 4150 Adrenocorticotropic hormone Allergy, human see Corticotropin Induction of immunological tolerance to major antigenic determinant of a-Adrenoreceptor penicillin: Therapeutic approach to penicillin allergy, 2091 Binding of [3H]dihydroazapetine to alpha-adrenoreceptor-related Allograft, skin proteins from rat vas deferens, 2730 Abnormal response to minor histocompatibility antigens in Obese strain Catecholamine-stimulated cyclic GMP accumulation in rat pineal: chickens, 2877 Apparent presynaptic site of action, 3398 Influence of polyunsaturated fatty acids on survival of skin allografts Adriamycin and tumor incidence in mice, 928 Bioenergetics in clinical medicine: Prevention by forms of coenzyme Q of Allosteric mechanism inhibition by adriamycin of coenzyme Qlo-enzymes in mitochondria of Kinetic evidence for hapten-induced conformational transition in myocardium, 4653 immunoglobulin MOPC 460, 3549 Affinity heterogeneity Subunit interfaces: Role in allosteric mechanism of hemoglobin, 3793 Negative homotropic cooperativity and affinity heterogeneity: Allosteric model Preparation of yeast glyceraldehyde-3-phosphate dehydrogenase with Nuclear magnetic resonance study of heme-heme interaction in maximal affinity homogeneity, 3928 hemoglobin M Milwaukee: Mechanism of cooperative ligand binding in Affinity label normal hemoglobin, 1581 Affinity label for i-adrenergic receptor in turkey erythrocytes, 1921 Rate of quaternary structure change in hemoglobin measured by Glycosylation of hemoglobin in vitro: Affinity labeling of hemoglobin by modulated excitation, 4497 glucose-6-phosphate, 3534 Alloxan-diabetes Interaction of integral and peripheral membrane proteins: Affinity Dietary and hormonal regulation of content of acetyl coenzyme A labeling of yeast cytochrome oxidase by modified yeast cytochrome c, carboxylase-synthesizing polysomes in rat liver, 2304 4334 Allozyme Aflatoxin Allelic heterogeneity within allozymes separated by electrophoresis in Mutagenicity of aflatoxins related to their metabolism and carcinogenic Drosophila pseudoobscura, 4150 potential, 2241 Allylisopropylacetamide Prophage X induction in Escherichia coli K12 envA uvrB: Sensitive test Cobalt inhibition of synthesis and induction of 1-aminolevulinate for potential carcinogens, 3700 synthase in liver, 1499 Age, human Altitude, high Relationship between in vitro cellular aging and in vivo human age, 3584 Sherpas living permanently at high altitude: Pattern of adaptation, 747 Agglutination Alveolar surface Immunologic and fine structure evidence of avidly bound host serum Direct determination of surface tension in lung, 4698 proteins in surface coat of bloodstream trypanosome, 1222 Amanita phalloides Agglutinin Conformation of uncomplexed [Phe4,Val6]antamanide crystallized from see also Wheat germ agglutinin nonpolar solvents, 1782 Idiotypic antigen on monoclonal cold agglutinin and on its isolated heavy a-Amanitin and light chains, 1702 in yeast: a-Amanitin sensitivity and other properties Aging which distinguish between RNA polymerases I and III, 1029 see also Longevity Amidophosphoribosyltransferase (EC 2.4.2.14) Absence of low-molecular-weight alpha crystallin in nuclear region of old Purine auxotroph deficient in phosphoribosylpyrophosphate human lenses, 3484 amidotransferase and phosphoribosylpyrophosphate aminotransferase High blood pressure related to carcinogen-induced unscheduled DNA activities with normal activity of ribose-5-phosphate aminotransferase, synthesis, DNA carcinogen binding, and chromosomal aberrations in 2458 human lymphocytes, 2496 Amine-catalyzed hydrolysis Aging, cell Amine-catalyzed hydrolyses of cyclodextrin cinnamates, 2969 Decreased fidelity of DNA polymerase activity isolated from aging a-Amino acetylation human fibroblasts, 2818 Enzymatic NH2-terminal acetylation of proteins with Relationship between in vitro cellular aging and in vivo human age, 3584 des-N"l-acetyl-ac-melanotropin as substrate, 3010 Aging, molecular Amino acid Modifications of purified glucose-6-phosphate dehydrogenase and other see also specific amino acids enzymes by a factor of low molecular weight abundant in some Amino acids and control of nucleolar size, the activity of RNA leukemic cells, 77 polymerase I, and DNA synthesis in liver, 3201 Alanine aminotransferase (EC 2.6.1.2) Degradative rates of proteins correlated with parameter calculated from Differential degradation of messenger RNAs in mammalian cells, 2634 amino acid composition and subunit size, 3093 5N nuclear magnetic resonance investigations on amino acids, 1409 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4719

Amino-acid activation Anabaena Diadenosine 5',5'"-P1,P4-tetraphosphate (Ap4A) in mammalian cells in Cyanobacterial DNA-binding protein related to Escherichia coli HU, levels varying widely with proliferative activity of tissue: Possible 1917 positive "pleiotypic activator", 3984 Analgesia Amino-acid analog see also Anesthetic lac : 3-Fluorotyrosine substitution for nuclear magnetic Endogenous opiate analgesic isolated from human blood, 2226 resonance studies, 3471 Opiate and stimulus-produced analgesia: Functional anatomy of Amino-acid metabolism medullospinal pathway, 4685 Hepatic glycogen synthesis stimulated by amino acids, 3433 Analgesic agent Amino-acid sequence - Endorphin is a potent analgesic agent, 2895 see also Peptide mapping Analogue solution Amino acid sequence at FdUMP binding site of thymidylate synthetase, Analogue solution for electrical capacity of membrane-covered cubes in 1848 cubic array at high concentration, 4003 Amino-acid sequence of equine renal metallothionein-IB, 3413 Androgen Amino-acid sequence of Fragment A, enzymically active fragment from Androgen insensitivity in man: Genetic heterogeneity, 891 diphtheria toxin, 69 Obligatory role of hypophysis in sexual differentiation of hepatic Amino-terminal sequences of two polypeptides from human serum with metabolism in rats, 1462 nonsuppressible insulin-like and cell-growth-promoting activities: Tissue interaction in androgen response of embryonic mammary Structural homology with insulin B chain, 4379 rudiment of mouse: Identification of target tissue for testosterone, Cell-free synthesis of rat preproinsulins: Characterization and partial 4041 amino acid sequence, 1964 Anemonia sulcata Characterization of 80-million-year-old mollusk shell proteins, 2541 Sea anemone toxin: Molecular mechanisms of nerve conduction and Correlations between specificity and sequence of first excitation-secretion coupling, 4055 complementarity-determining segments of human kappa light chains, Anesthetic 4471 see also Analgesia Detergent-soluble HLA antigens contain hydrophilic region at the Amphipathic amines affect membrane excitability in Paramecium COOH-terminus and penultimate hydrophobic region, 2481 aurelia: Role for bilayer couple, 452 Hemoglobin Wayne: Frameshift mutation detected in human Combined effects of dissociable and undissociable local anesthetics upon hemoglobin alpha chains, 882 ATP-induced firefly bioluminescence, 1868 HLA membrane antigens: Sequencing by intrinsic radioactivity, 4487 Molecular mechanism of inhibition of firefly luminescence by local Human liver and placental alkaline phosphatase isoenzymes are coded anesthetics, 481 by different genes, 2201 Multiple factor analysis of action of local anesthetics, 3726 Hydrophobicity of NH2-terminal extra piece of immunoglobulin Nuclear magnetic resonance studies of interaction of general anesthetics light-chain precursors: Physiological functions of extra piece, 3273 with 1,2-dihexadecyl-sn-glycero-3-phosphorylcholine bilayer, 3999 Immunoglobulin allotypes of rabbit kappa chains: Polymorphism of Aneuploidy control mechanism regulating closely linked duplicated genes? 1293 Rates of evolution in seed plants: Net increase in diversity of Isolation, primary structure, and synthesis of a-endorphin and chromosome numbers and species numbers through time, 2086 -y-endorphin, two peptides of hypothalamic-hypophysial origin with Angiotensin converting enzyme morphinomimetic activity, 3942 Elevated angiotensin converting enzyme in lymph nodes containing Membrane penicillinase of Bacillus licheniformis 749/C: Sequence and non-necrotizing granulomas in sarcoidosis, 2137 possible repeated tetrapeptide structure of phospholipopeptide region, Angiotensin II 1457 Prostaglandin E synthesis in cultured human umbilical vein smooth Mouse amyloid protein AA: Homology with nonimmunoglobulin protein muscle cells, 1617 of human and monkey amyloid substance, 964 Anodynin Partial amino-acid sequence of H-2K molecule, 905 Endogenous opiate analgesic isolated from human blood, 2226 Partial amino-acid sequence of precursor of immunoglobulin light chain Antamanide containing NH2-terminal pyroglutamic acid, 2604 Conformation of uncomplexed [Phe4,Val5lantamanide crystallized from Protein products of murine chromosome 17: Partial amino acid sequence nonpolar solvents, 1782 of H-2Kb molecule, 3661 Antheraea pernyi Segment-long-spacing aggregates and isolation of COOH-terminal DNA sequence organization in lepidopteran Antherasa pernyi, 2289 peptides from type I procollagen, 4304 Antibiotic Size differences among immunoglobulin heavy chains from see also specific antibiotics phosphorylcholine-binding proteins, 2109 Nitrofurans, a group of synthetic antibiotics, with a new mode of action: Structure and evolution of transplantation antigens: Partial amino-acid Discrimination of specific messenger RNA classes, 3386 sequences of H-2K and H-2D alloantigens, 599 Transcription-translation and translation-messenger RNA decay 'ropomyosin-binding component of rabbit skeletal muscle troponin: coupling: Separate mechanisms for different messengers, 1126 Amino-acid sequence, 1902 Antibiotic, beta lactam Tropomyosin-binding component of rabbit skeletal muscle troponin: Suppression of lytic effect of beta lactams on Escherichia coli and other Amino-acid sequence (correction), 4711 bacteria, 3293 Amino-acid substitution Antibody against acetyl-CoA carboxylase Molecular abnormality of human alpha,-antitrypsin variant (Pi-ZZ) Dietary and horrponal regulation of content of acetyl coenzyme A associated with plasma activity deficiency, 1324 carboxylase-synthesizing polysomes in rat liver, 2304 Aminoacyl-tRNA synthetase Antibody against breast cancer Position of aminoacylation of individual Escherichia coli and yeast Isolation from patients with breast cancer of antibodies specific for tRNAs, 405 antigens associated with breast cancer and other malignant diseases, Subcellular localization of S-adenosyl-L-methionine:tRNA 2101 methyltransferases with aminoacyl-tRNA synthetases in human and Antibody against hamster ovarian antigens mouse: Normal and leukemic leukocytes, 3857 Immunological block to mammalian fertilization: Survival and organ 2-Aminobicyclo[2.2.11heptane-2-carboxylic acid distribution of immunoglobulin which inhibits fertilization in vito, Insulin release and phosphate ion efflux from rat pancreatic islets 2405 induced by li-leucine and its nonmetabolizable analogue, Antibody against insulin receptor 2-aminobicyclo[2.2. 1 heptane-2-carboxylic acid, 3403 Detection and characterization of cell surface receptors for insulin by a-Aminoisobutyric acid means of 2'51-labeled autoantibodies against insulin receptor, 4115 Induction and decay of glucagon-induced amino acid transport in Antibody against morphine primary cultures of adult rat liver cells: Paradoxical effects of Antibodies as a means of isolating and characterizing biologically active cycloheximide and puromycin, 4511 substances: Nonpeptide, morphine-like compound in central nervous Sodium-stimulated av-aminoisobutyricacid transport by membrane system, 2132 vesicles from simian virus-transformed mouse cells, 1907 Antibody against muscle protein 6-Aminolevulinate synthase (EC 2.3.1.37) Immunological characterization of subunit of 100 A filaments from Cobalt inhibition of synthesis and induction of b-aminolevulinate muscle cells, 4344 synthase in liver, 1499 Antibody against translocator protein Selenium regulation of hepatic heme metabolism: Induction of Antibody evidence for different conformational states of AI)P,ATP 1-aminolevulinate synthase and heme oxygenase, 4428 translocator protein isolated from mitochondria, 2280 3-Aminopyridine Antibody against viral envelope antigen Presynaptic calcium currents and relation to synaptic transmission: Natural antibodies in sera from healthy humans to antigens on surfaces Voltage clamp study in squid giant synapse and theoretical model for of type C RNA viruses and cells from primates, 2491 calcium gate, 2918 Antibody, anti-hapten Amphibia Elimination of rotating carrier mechanism for active transport of Ca ion Caecilian ear, 3744 in sarcoplasmic reticulum membranes, 1532 Amphipathic amines Antibody, cell production of Amphipathic amines affect membrane excitability in Paramecium Antibody-producing cells: Virus-induced alteration of response to aurelia: Role for bilayer couple, 452 antigen, 1707 Amplification convertase Antibody combining site Amplification convertase of complement is controlled by plasma protein Attempts to locate residues in complementarity-determining regions of 4 H, 3268 antibody combining sites that make contact with antigen, 617 Amyloid protein AA Antibody, C-type virus Mouse amyloid protein AA: Homology with nonimmunoglobulin protein Antigens and antibodies crossreactive with type C viruses of woolly of human and monkey amyloid substance, 964 monkey and gibbon ape in animal models and in humans, 1725 Downloaded by guest on October 5, 2021 4720 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Antibody-dependent cell killing Antigen receptor, lymphocyte Cells that express viral antigens but lack H-2 determinants are not lysed Geneticpolymorphism of IgD-likecell surfaceimmunoglobulin in mouse, by immune thymus-derived lymphocytes but are lysed by other 1305 antiviral immune attack mechanisms, 3666 Antigen response Antibody diversity Antibody-producingcells: Virus-inducedalteration of responseto No detectable reiteration of genes coding for mouse MOPC 41 antigen, 1707 immunoglobulin light-chain mRNA, 727 Antigen stimulation Reiteration frequency of immunoglobulin light chain genes: Somatic Antigenstimulation of prostaglandinsynthesis and controlof immune generation of antibody diversity, 203 responses,1300 Antibody, fluorescein-conjugated Antigen structure Biological molecules identified in situ at high resolution via fluorescence Role of antigenicstructure in cell to cell cooperation,4184 excited by scanning electron beam, 317 Antigen, synthetic Antibody function Antiviraleffect on MS-2 coliphageobtained with synthetic antigen,4636 Kinetic evidence for hapten-induced conformational transition in Immunologicalcrossreactivity of antibodiesto synthetic undecapeptide immunoglobulin MOPC 460, 3549 analogousto amino-terminalsegment of carcinoembryonicantigen, Antibody, IgD with intact proteinand with humansera, 2123 Genetic polymorphism of IgD-like cell surface immunoglobulin in mouse, Antigen, synthetic polypeptide 1305 Role of antigenicstructure in cell to cell cooperation,4184 Measles virus-specific IgD antibodies in patients with subacute Antigen, thymus-dependent sclerosing panencephalitis, 1297 Role of antigenicstructure in cell to cell cooperation,4184 Antibody, specific neutralizing Antigen, tobacco Prevention of viral-chemical co-carcinogenesis in vitro by type-specific Hypersensitivityto tobaccoantigen, 1712 anti-viral antibody, 152 Antigen, transplantation Antibody, tubulin Papain cleavagesite of H-2 glycoproteins,915 Cytoplasmic microtubules in tissue culture cells appear to grow from Structureand evolutionof transplantationantigens: Partial amino-acid organizing structure towards plasma membrane, 867 sequencesof H-2K and H-2D alloantigens,599 Antibody, tumor-specific Antigen, tumor Isolation from patients with breast cancer of antibodies specific for Autoregulationof simianvirus 40 gene A by T antigen,3083 antigens associated with breast cancer and other malignant diseases, "Early"simian-virus-40-specific RNA containsinformation for tumor 2101 antigen formationand chromatinreplication, 366 Antidiuretic hormone Monomermolecular weight of T antigen from simian virus 40-infected see Vasopressin and transformedcells, 2254 Antigen Simian-virus-40-specificT-antigen: Two forms in abortiveand lytic see also Carcinoembryonic antigen; Leukemia Ia antigens infection, 1097 Antigen, cell surface Simian virus 40 tumor-specificproteins in nucleusand plasma Cell surface antigens of human malignant melanoma: Mixed membraneof HeLa cells infected by adenovirus2-SV40 hybridvirus hemadsorption assays for humoral immunity to cultured autologous Ad2+ND2,2505 melanoma cells, 3278 Viraltranscription and tumorantigen expression regulated in cells Genetics of somatic mammalian cells: Genetic, immunologic, and transformedby simianvirus 40, 1931 biochemical analysis with Chinese hamster cell hybrids containing Antigen, tumor-specific transplantation selected human chromosomes, 193 Simian virus 40 tumor-specificproteins in nucleusand plasma Ia-like molecules on surface of normal and leukemic human cells, 1288 membraneof HeLa cells infected by adenovirus2-SV40 hybrid virus Interferon treatment of mice: Enhanced expression of histocompatibility Ad2+ND2,2505 antigens on lymphoid cells, 1284 Antigen, U Antigen, chromatin Simian virus 40 tumor-specificproteins in nucleus and plasma Fetal protein in chromatin of Novikoff hepatoma and Walker 256 membraneof HeLa cells infected by adenovirus2-SV40 hybrid virus carcinosarcoma tumors that is absent from normal and regenerating Ad2+ND2,2505 rat liver, 3258 Antihemophilic factor Antigen, C-type virus Clonalgrowth of bovine vascularendothelial cells: Fibroblastgrowth Antigens and antibodies crossreactive with type C viruses of woolly factoras survivalagent, 4120 monkey and gibbon ape in animal models and in humans, 1725 Antinociceptive response Antigen, embryonal carcinoma (-Endorphin:Cross tolerance to and cross physicaldependence on see also Carcinoembryonic antigen morphine,4187 Embryonal carcinoma antigen and Tit locus of mouse, 4080 Antipyrine Antigen, Epstein-Barr virus Interactionsbetween nutritional factors and drug biotransformationsin Differential effect of phosphonoacetic acid on expression of man, 2501 Epstein-Barr viral antigens and virus production, 1745 Antiserum against tubulin Antigen, Gix thymocyte Antiseraagainst electrophoreticallypurified tubulin stimulate Heredity of GIx thymocyte antigen associated with murine leukemia colchicine-bindingactivity, 1246 virus: Segregation data simulating genetic linkage, 2077 Antiserum, monospecific Antigen, group-specific Interrelationshipof hexosaminidasesA and B: Confirmationof common Mapping oligonucleotides of Rous sarcoma virus RNA that segregate and uniquesubunit theory, 2833 with polymerase and group-specific antigen markers in recombinants, al-Antitrypsin deficiency 3952 Molecularabnormality of humanalphal-antitrypsin variant (Pi-ZZ) Antigen, histocompatibility associatedwith plasmaactivity deficiency,1324 see also Histocompatibility complex; Major histocompatibility complex Aorta Abnormal response to minor histocompatibility antigens in Obese strain Aryl 4-monooxygenaseand cytochromeP-450 in aorta:Role in chickens, 2877 atherosclerosis,3723 Cell-mediated cytolysis of trinitrophenyl-derivatized target cells Biosynthesisof lipid-linkedoligosaccharides and glycoproteinin aorta: inhibited by alloantisera directed to products of K and D loci of the Stimulationby acceptorlipids isolated from liver, 2574 H-2 complex, 625 Characterizationof collagensynthesized by endothelialcells in culture, Cells that express viral antigens but lack H-2 determinants are not lysed 2361 by immune thymus-derived lymphocytes but are lysed by other Aortic endothelium antiviral immune attack mechanisms, 3666 Replicatingcells cluster in aortic endothelium,651 Detergent-soluble HLA antigens contain hydrophilic region at the Aphagia COOH-terminus and penultimate hydrophobic region, 2481 Bandage-backfallreaction: Occurs in infancy,hypothalamic damage, and HLA membrane antigens: Sequencing by intrinsic radioactivity, 4487 catalepsy,3311 Interferon treatment of mice: Enhanced expression of histocompatibility Aphanocapsa antigens on lymphoid cells, 1284 CyanobacterialDNA-binding protein related to Escherichiacoli HU, Papain cleavage site of H-2 glycoproteins, 915 1917 Partial amino-acid sequence of H-2K molecule, 905 Aplastic anemia Protein products of murine chromosome 17: Partial amino acid sequence Aplasticanemia: Presence in humanbone marrowof cells that suppress of H-2Kb molecule, 3661 myelopoiesis,2890 Structure and evolution of transplantation antigens: Partial amino-acid Aplastidic mutant sequences of H-2K and H-2D alloantigens, 599 Largesubunit ribulosebisphosphatecarboxylase messenger RNA from Structure of HLA antigens: Amino-acid and carbohydrate compositions Euglena chloroplasts, 722 and NH2-terminal sequences of four antigen preparations, 910 Aplysia Subunit structure, cell surface orientation, and partial amino-acid Intraneuronal guanylyl-imidodiphosphate injection mimics long-term sequences of murine histocompatibility antigens, 118 synaptic hyperpolarization in Aplysia, 4689 Antigen, idiotypic Apolipoprotein Idiotypic antigen on monoclonal cold agglutinin and on its isolated heavy see also Lipoprotein and light chains, 1702 Apolipoproteins in rat serum and renal lymph, 1757 Antigen, murine leukemia virus Human blood plasma protein, rich in proline, with lipid-binding Changes in expression of murine leukemia virus antigens and production properties, 1063 of xenotropic virus in the late preleukemic period in AKR mice, 4680 Solid phase synthesis of protein activator for lecithin-cholesterol Antigen, P acyltransferase corresponding to human plasma apoC-I, 1422 Glycosphingolipid content of human pk and p erythrocytes, 3263 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4721

Apomorphine Rat sympathetic neurons and cardiac myocytes developing in Dopaminereceptors in humanand calf brains,using [3H]apomorphine microcultures: Correlation of fine structure of endings with and an antipsychoticdrug, 4354 neurotransmitter function in single neurons, 4220 Appliedmathematical sciences Authors' statement Inverseproblem for convex bodies, 1377 In vivo splicingof protein:One continuouspolypeptide from two Appliedmathematics independently functioning (correction), 661 Evolution,population dynamics, and stability,665 Autoimmune disease Appliedphysical sciences Experimental myasthenia in Balb/c mice immunized with rat Equilibriumand stability code for a diffuse plasma,984 acetylcholine receptor from rat denervated muscle, 2872 Soft polymers:Time-dependent response in moderatelylarge Human myasthenia gravis: Electrophysiological and ultrastructural deformations,981 evidence compatible with antibody attachment to acetylcholine van der Waals-typeequation of state for fluids with associating receptor complex, 4584 molecules,1773 Autoimmunity Arachidonicacid Abnormal response to minor histocompatibility antigens in Obese strain Inhibitionof arachidonicacid release from cells as biochemicalaction of chickens, 2877 anti-inflammatorycorticosteroids, 1730 Diet: Influence on survival of mice, 1279 Arginineesterase Automorphic forms Inductionof humanfibroblast proliferation by epidermalgrowth factor Relation between automorphic forms on GL(2) and GL(3), 3348 (EGF):Enhancement by EGF-bindingarginine esterase and by Autonomic nervous system ascorbate,183 Innervation of heart cells in culture by endogenous source of cholinergic Argiope neurons, 4506 Ploy and counterployin predator-preyinteractions: Orb-weaving spiders Avian myeloblastosis virus versus bombardierbeetles, 1365 Anticomplementary nature of smaller DNA produced during synthesis of Artemiasalina extensive DNA copies of poliovirus RNA, 3408 Polypeptidechain initiationin eukaryotes:Initiation factor requirements Circularization of avian oncornavirus RNA genome during proviral DNA for translationof naturalmessengers, 44 synthesis studied by reverse transcription in vitro, 1329 Polypeptidechain initiationin eukaryotes:Mechanism of formationof DNA copies of poliovirus RNA synthesized in high yields and at high initiationcomplex, 298 specific activities, 2191 Protein bindingmethylated 5'-terminal sequence, m7GpppN, of Stepwise biosynthesis in vitro of globin genes from globin mRNA by eukaryoticmessenger RNA, 1559 DNA polymerase of avian myeloblastosis virus, 3418 Arterialperfusion pressure Tandem integration of avian myeloblastosis virus DNA with endogenous Renal CO2production from glutamine and lactate as functionof arterial provirus in leukemic chicken cells, 1749 perfusionpressure in dog, 4235 Avidin Arteryocclusion Targeted attachment of peptides and proteins to solid supports, 3516 Effect of main arteryocclusion of one kidneyon blood pressureof dogs, Axon 1722 Spike-forming model of neural membrane: Computer simulation of Arylamineglass additional perfused axon experiments, 100 Immobilizationof bacterialluciferase and FMN reductaseon glass rods, Azapetine, dihydro- 3848 Binding of [3H]dihydroazapetine to alpha-adrenoreceptor-related Aryl hydrocarbonhydroxylase proteins from rat vas deferens, 2730 see Flavoprotein-linkedmonooxygenase Azathioprine Aryl 4-monooxygenase(EC 1.14.14.1) Prevention and suppression by azathioprine of venom-induced Aryl 4-monooxygenaseand cytochromeP-450 in aorta:Role in protein-losing gastropathy in dogs, 968 atherosclerosis,3723 Azurin Ascorbate Applications of synchrotron radiation to protein crystallography, 128 Gene for L-gulono--y-lactoneoxidase is not expressedin animalssubject Blue copper centers in proteins, spectroscopic studies and structural to scurvy:Immunologic evidence, 2066 model, 1389 Inductionof humanfibroblast proliferation by epidermalgrowth factor (EGF):Enhancement by EGF-bindingarginine esterase and by ascorbate,183 Bacillus Calmette-Guerin Simultaneoussynthesis of types I and III collagenby fibroblastsin Partial purification of serum factor that causes necrosis of tumors, 381 culture,4037 Bacillus licheniformis Supplementalascorbate in supportivetreatment of cancer:Prolongation Membrane penicillinase of Bacillus licheniformis 749/C: Sequence and of survivaltimes in terminalhuman cancer, 3685 possible repeated tetrapeptide structure of phospholipopeptide region, Asparaginase(EC 3.5.1.1) 1457 Antibody-producingcells: Virus-inducedalteration of responseto Bacillus megaterium antigen, 1707 Fusion of protoplasts of Bacillus megaterium, 2147 Asplanchnasieboldi Oligomeric intermediate in peptidoglycan biosynthesis in Bacillus Selective cannibalismin rotiferAsplanchna sieboldi: Contact recognition megaterium, 4200 of morphotypeand clone, 3233 Bacillus stearothermophilus Astronomy Lack of ribosomal protein S1 in Bacillus stearothermophilus, 767 Allendemeteorite: Isotopically anomalous xenon is accompaniedby Bacillus subtilis normalosmium, 4253 Altered penicillin-binding components in penicillin-resistant mutants of Chronometriccosmology, theoretical foundations, 669 Bacillus subtilis, 1816 Solarabundance of iridium,269 Control of development: Role of regulatory nucleotides synthesized by Solarabundance of osmium,1382 membranes of Bacillus subtilis in initiation of sporulation, 331 Unstablespiral modes in disk-shapedgalaxies, 1379 Fusion of bacterial protoplasts, 2151 Unstable spiralmodes in disk-shapedgalaxies: Enhancement of growth Helical growth of Bacillus subtilis: Model of cell growth, 1740 rate, 3785 Bacterial division septum Atherosclerosis Morphogenesis of bacterial division septum: Class of septation-defective Alterationsin cell surfaceglycosphingolipids and other lipid classes of mutants, 1882 fibroblastsin familialhypercholesterolemia, 4339 Bacterial envelope Aryl 4-monooxygenaseand cytochromeP-450 in aorta:Role in Cellulose biosynthesis in Acetobacter xylinum: Visualization of site of atherosclerosis,3723 synthesis and direct measurement of in vivo process, 4565 Cellularcholesterol ester accumulationinduced by free cholesterol-rich fl lipid dispersions,3680 Origin and direction of synthesis of bacteriophage fl DNA, 2341 Fatty acyl-CoAoxidizing system in rat liver peroxisomes:Enhancement Bacteriophage F2 by clofibrate,a hypolipidemicdrug, 2043 Lack of ribosomal protein SI in Bacillus stearothermophilus, 767 Geneticvariation in serumlow density lipoproteinsand lipid levels in Bacteriophage fd man, 937 DNA fragment from origin of single-strand to double-strand DNA Replicatingcells clusterin aortic endothelium,651 replication of bacteriophage fd, 49 Atomicabsorption Psoralen-crosslinked secondary structure map of single-stranded virus Ability of insulin to increasecalcium binding by adipocyteplasma DNA, 2649 membranes,1542 Bacteriophage G4 ATP:citrate(pro-3S)-lyase (EC 4.1.3.8) Kinetics of branch migration in double-stranded DNA, 2299 Klebsiellaaerogenes citrate (pro-3S)-lyase:Structure of prosthetic Bacteriophage, hybrid group, 1872 mot gene product identified with Escherichia col-lambda hybrids, 3126 Auger electron emission Bacteriophage inactivation Extended x-ray-absorption fine structure-Auger process for surface Immunological crossreactivity of antibodies to synthetic undecapeptide structure analysis: Proposed experiment, 2550 analogous to amino-terminal segment of carcinoembryonic antigen, Aurintricarboxylic acid with intact protein and with human sera, 2123 Polynucleotide secondary structure altered by ribosomal protein S1, 1824 Bacteriophage X Autapse Construction and propagation of defective simian virus 40 genome Chemical transmission between rat sympathetic neurons and cardiac bearing operator from bacteriophage A, 1068 myocytes developing in microcultures: Evidence for cholinergic, adrenergic, and dual-function neurons, 4225 Downloaded by guest on October 5, 2021 4722 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Construction of plasmids carrying the cI gene of bacteriophage X, 4174 Base pairing, mismatched Deletions of lambda phage locating a prm mutation within rightward Mismatched base-pair-regions in polyoma heteroduplex DNA: Fate operator, 712 during infection of mouse cells, 3073 DNA-binding protein with characteristics expected for Cro protein of Base stacking bacteriophage X, a repressor essential for lytic growth, 2249 Ultraviolet photoelectron studies of biological purines: Valence electronic Identification of recombinants of phage X, 3394 .structure of adenine, 2966 Induction of synthesis in Escherichia coli by the N gene Bedload measurement product of bacteriophage lambda, 4405 Bedload measurements, East Fork River, Wyoming, 1000 Prokaryotic DNA visualized in a regularly condensed chromatin-like Beetle, bombardier fiber, 563 see Brachinus Repair tracts in mismatched DNA heteroduplexes, 4135 Beetle, flour Restriction assay for integrative recombination of bacteriophage X DNA see Tribolium in vitro: Requirement for closed circular DNA substrate, 3524 Behavior Restriction endonuclease isolated from Haemophilus parahaemolyticus, Anesthetic stimulation of insect water receptors, 3315 293 Chemo-anemotaxis: Behavioral response to sex pheromone in nonflying Significance of constitutive integrase synthesis, 887 insects, 2524 Single burst study of rec- and red-mediated recombination in Multiple pheromone system controlling mating in Drosophila bacteriophage lambda, 4613 melanogaster, 591 Specialized transduction of colicin E1 DNA in Escherichia coli K-12 by Behavioral mutant phage lambda, 3238 Neurophysiological defects in temperature-sensitive paralytic mutants of Transposition of R factor genes to bacteriophage X (correction), 977 Drosophila melanogaster, 3253 Bacteriophage M13 Behavior, genetics Asymmetric orientation of phage M13 coat protein in Escherichia coli Courtship in Drosophila mosaics: Sex-specific foci for sequential action cytoplasmic membranes and in synthetic lipid vesicles, 1159 patterns, 4154 Bacteriophage MS2 dunce, a mutant of Drosophila deficient in learning, 1684 Antiviral effect on MS-2 coliphage obtained with synthetic antigen, 4636 Behavior, mating Secondary structure of single-stranded RNA from bacteriophage MS2 by Ethological isolation and mating experience in Drosophila paulistorum, electron microscopy, 307 975 Bacteriophage 080 Behavior, sexual Ribonuclease P substrate specificity: Cleavage of bacteriophage Courtship in Drosophila mosaics: Sex-specific foci for sequential action 080-induced RNA, 1912 patterns, 4154 Bacteriophage 4-3-T Beneekea harveyi Expression of thymidylate synthetase gene of Bacillus subtilis Inhibition and stimulation of development of bioluminescent system in bacteriophage Phi-3-T in Escherichia coli, 4145 Beneckea harveyi by cyclic GMP, 4454 Bacteriophage OX174 Benz[a]anthracene, 7,12-dimethyl- DNA synthesis in vitro dependent upon XX174 replicative form I DNA, DimethylsUlfoxide-induced differentiation and hemoglobin synthesis in 1887 tissue cultures of rat erythroleukemia cells transformed by Enzymatic replication of viral and complementary strands of duplex 7,12-dimethylbenz(a)anthracene, 1237 DNA of phage bX174 proceeds by separate mechanisms, 3151 High blood pressure related to carcinogen-induced unscheduled DNA Enzyme system for replication of duplex circular DNA: Replicative form synthesis, DNA carcinogen binding, and chromosomal aberrations in of phage bX174, 1594 human lymphocytes, 2496 Intermediate isolated which precedes dnaG RNA polymerase Prophage A induction in Escherichia coli K12 envA uvrB: Sensitive test participation in enzymatic replication of bacteriophage 4X174 DNA, for potential carcinogens, 3700 752 Structure of 7,12-dimethylbenz[a]anthracene-guanosine adducts, 2311 Isolation and characterization of protein coded by gene A of Benzo[a]pyrene bacteriophage 5X174 DNA, 2669 Control of growth of benzo[a]pyrene-transformed 3T3 cells, 3229 Mapping of in vivo messenger RNAs for bacteriophage 4X174, 3519 ( ? ) -7a,8/-Dihydroxy-9/?,10#-epoxy-7,8,9,10-tetrahydrobenzo[a] pyrene is Mapping of in vivo messenger RNAs for bacteriophage qX174 an intermediate in metabolism and binding to DNA of benzo[a]pyrene, (correction), 4247 2679 Recombination promoted by superhelical DNA and recA gene of Enzymatic conversion of benzofalpyrene leading predominantly to the Efcherichia coli, 3910 diol-epoxide r-7-t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo- Bacteriophage Q. [a]-pyrene through a single enantiomer of Qo RNA replicase reconstituted from covalently bonded elongation r-7,t-8-dihydroxy-7,8-dihydrobenzo[a]pyrene, 2594 factor Tu-Ts complex, 1131 Enzyme catalyzed covalent binding of benzo[a]pyrene to poly(G), 1117 Bacteriophage SPOI Hydrocarbon structure in enzyme-catalyzed benzo[a]pyrene-poly(G) Conversion of Bacillus subtilis'RNA polymerase activity in vitro by a covalent complex, 1437 protein induced by phage SPOI (correction), 661 Metabolism of benzo[a]pyrene: Conversion of Bacteriophage T3 (::)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly Bacteriophage T3 and T7 early RNAs are translated by eukaryotic 80S mutagenic 7,8-diol-9,10-epoxides, 3381 ribosomes: Active phage T3 coded S-adenosylmethionine cleaving Mutagenic metabolites of benzo[a]pyrene identified in mammalian cells, enzyme is synthesized, 2752 607 Bacteriophage T4 Prophage A;induction in Escherichia coli Ki2 envA uvrB: Sensitive test Bacteriophage T4 gene whose product prevents true late transcription on for potential carcinogens, 3700 -containing T4 DNA, 3098 (+-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a] pyrene: Potent skin Heat mutagenesis in bacteriophage T4: Transition pathway, 1269 carcinogen when applied topically to mice, 3867 Heat mutagenesis in bacteriophage T4: Transversion pathway, 4159 Benzo[a]pyrene, arene oxides of Induction of delayed early RNA of bacteriophage T4 in vitro, 2569 Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse Protein cleavage during virus assembly: Specificity of assembly skin, 243 dependent cleavage in bacteriophage T4, 4205 Benzomorphan Simultaneous initiation of synthesis of bacteriophage T4 DNA and of Opiate receptor: Model explaining structure-activity relationships of deoxyribonucleotides, 757 opiate agonists and antagonists, 4215 Transcription-translation and translation-messenger RNA decay Bergman metric coupling: Separate mechanisms for different messengers, 1126 Completeness of Bergman metric and its subordinate metric, 4294 Bacteriophage T5. Bernstein polynomials Bacteriophage T5-induced endonucleases that introduce site-specific Bernstein polynomials and Milnor algebras, 2546 single-chain interruptions in duplex DNA, 1576 Beryllium Bacteriophage T7 Metal-induced infidelity during DNA synthesis, 2331 Bacteriophage T3 and T7 early RNAs are translated by eukaryotic 80S Beta sheet ribosomes: Active phage T3 coded S-adenosylmethionine cleaving Handedness of crossover connections in d sheets, 2619 enzyme is synthesized, 2752 Biholomorphism Escherichia coli thioredoxin: Subunit of bacteriophage T7 DNA Structure of complete simply-connected Kahler manifolds with polymerase, 780 nonpositive curvature, 1008 Genetic recombination of bacteriophage T7 DNA in vitro, 692 Bilinear organic addition compound Molecular cloning of DNA from F sex factor of Escherichia coli K-12, 64 Conductivity and structure of bilinear organic addition compounds, 3820 Polycistronic and overlapping bacteriophage T7 late transcripts detected Biliprotein by in vitro translation, 312 Biliproteins of cyanobacteria and Rhodophyta: Homologous family of Bandage-backfall reaction photosynthetic accessory pigments, 428 Bandage-backfall reaction: Occurs in infancy, hypothalamic damage, and Binding site, FdUMP catalepsy, 3311 Amino acid sequence at FdUMP binding site of thymidylate synthetase, Barium 1848 Free acid, anion, alkali, and alkaline earth complexes of lasalocid A Binding site, mercaptide (X537A) in methanol: Structural and kinetic studies at monomer level, Amino-acid sequence of equine renal metallothionein-lB, 3413 4277 Binding site, toxin Base pairing Photoaffinity labeling and quaternary structure of acetylcholine receptor Crystal structure of complex between lumiflavin and from Torpedo californica, 2624 2,6-diamino-9-ethylpurine: Flavin adenine dinucleotide model Bioactivation exhibiting charge-transfer interactions, 3807 Aryl 4-monooxygenase and cytochrome P-450 in aorta: Role in Base pairing, intramolecular atherosclerosis. 3723 Double-stranded RNA in chromatin transcripts formed by exogenous RNA polymerase, 1121 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4723

Biochemicalkinetic diagram Biotinyl protein Free energylevels and entropyproduction associated with biochemical Targetedattachment of peptides and proteinsto solid supports,3516 kinetic diagrams,95 Birds Biochemicalmarker see also Chicken;Darwin's finches; Solomon Archipelago, birds of Elevatedserum ribonuclease in patients with pancreaticcancer, 2308 Birds on islands in the sky: Originof montaneavifauna of Northern Biocontrol Melanesia,1765 Chemo-anemotaxis:Behavioral response to sex pheromonein nonflying Calculationof immigrationand extinction curvesfrom insects, 2524 species-area-distancerelation, 4130 Bioelectricity Species-distancerelation for birds of SolomonArchipelago, and paradox Transductionof chemicalinto electricalenergy, 82 of great speciators,2160 Bioenergetics BK virus Bioenergeticsin clinicalmedicine: Prevention by formsof coenzymeQ of BK virus DNA occursin DNA obtainedfrom certain humantumors, inhibitionby adriamycinof coenzymeQio-enzymes in mitochondriaof 4662 myocardium,4653 Blastocladiellazoospore germination Chargepair model of bioenergetics:Redox enzymes,2392 Chitin biosynthesisduring Blastocladiella zoosporegermination: Chargepair model of bioenergetics:Energy transfer, 2770 Hexosaminebiosynthetic pathway is post-translationallyactivated Biogenesis duringcell differentiation,534 Biogenesisof mitochondria:Molecular mapping of mitochondrialgenome Blastogenesis of yeast, 2082 y-Glutamyltranspeptidase, a lymphoidcell-surface marker: Relationship Biogeography to blastogenesis,differentiation, and neoplasia,2414 Birds on islands in the sky: Originof montaneavifauna of Northern Blind spot Melanesia,1765 Metabolicmapping of primaryvisual system of monkeyby Calculationof immigrationand extinctioncurves from autoradiographic[14C]deoxyglucose technique, 4230 species-area-distancerelation, 4130 Blood-aqueousbarrier Species-arearelation for birds of SolomonArchipelago, 262 Blood-aqueousbarrier can be circumventedby loweringintraocular Species-distancerelation for birds of SolomonArchipelago, and paradox pressure,638 of great speciators,2160 Blood coagulation Bioluminescence Involvementof high molecularweight kininogenin surface-dependent Immobilizationof bacterialluciferase and FMN reductaseon glass rods, reactionsof Hagemanfactor, 2554 3848 Blood, peripheral Inhibitionand stimulationof developmentof bioluminescentsystem in Polyclonalactivation of bone-marrow-derivedlymphocytes from human Beneckea harveyi by cyclic GMP, 4454 peripheralblood measuredby direct plaque-formingcell assay, 3676 Biophotolysisof water Blood plasma,human Separationof hydrogenase-catalyzedhydrogen-evolution system from Humanblood plasmaprotein, rich in proline,with lipid-binding electron-donatingsystem by enzymicelectric cell technique,2947 properties,1063 Biophysics Blood pressure Affinityof myosin S-1 for F-actin, measuredby time-resolved Effect of main arteryocclusion of one kidney on blood pressureof dogs, fluorescenceanisotropy, 133 1722 Affinityof myosin S-1 for F-actin, measuredby time-resolved Bloodstreamtrypanosome fluorescenceanisotropy (correction), 2527 Immunologicand fine structureevidence of avidly bound host serum Analoguesolution for electricalcapacity of membrane-coveredcubes in proteinsin surfacecoat of bloodstreamtrypanosome, 1222 cubic arrayat high concentration,4003 Blood substitute Applicationof polarizationeffects in light scattering,486 Solubledextran-hemoglobin complex: Potential blood substitute, 2128 Applicationsof synchrotronradiation to proteincrystallography, 128 Blowfly Catalasemonolayers inactivated by irradiationwith 100 keV electrons, see Phormiaregina 823 Blue-greenalgae Chargepair model of bioenergetics:Redox enzymes,2392 see Cyanobacteria Chargepair model of bioenergetics:Energy transfer, 2770 B-lymphocyte Conformationalflexibility and protein folding:Rigid structural see Lymphocyte,bone-marrow-derived; Lymphocyte, bursa-dependent fragmentsconnected by flexiblejoints in subtilisinBPN, 1974 Bond orbital,hybrid Conformationof deazapurinenucleosides and of commonpurine Correlationof nonorthogonalityof best hybridbond orbitalswith bond nucleosides:Study by circulardichroism, 2384 strengthof orthogonalorbitals, 274 DNA strand breaks,repair, and survivalin x-irradiatedmammalian cells, Metal-metal bond lengths in complexesof transitionmetals, 4290 809 Bond orbital,orthogonal Electronprobe x-ray analysisof single ferritinmolecules, 1193 Anglesbetween orthogonal spd bond orbitalswith maximumstrength, Electrophoreticdistributions of humanperipheral blood mononuclear 1403 white cells from normalsubjects and from patients with acute Correlationof nonorthogonalityof best hybridbond orbitalswith bond lymphocyticleukemia, 2388 strengthof orthogonalorbitals, 274 "Energyupconversion" theory for green plant photosynthesis,2773 Bone Erythrocytemembranes undergo cooperative, pH-sensitive state -y-Carboxyglutamicacid-containing protein from bone, 1447 transitionsin physiologicaltemperature range: Evidence from Raman ^-Carboxyglutamicacid-containing protein from bovine bone:Primary spectroscopy,3558 structure,3374 Erythrocytephosphate transport inhibited by high pressures,2767 Controlof renal vitaminD hydroxylasesin birds by sex hormones,2701 Inelasticelectron tunneling spectroscopy of nucleic acid derivatives,1598 Bone marrow Isolatedacetylcholine receptor protein: Kinetics of bindingof Aplasticanemia: Presence in humanbone marrowof cells that suppress acetylcholineand Ca ions, 3994 myelopoiesis,2890 Kinetic evidencefor hapten-inducedconformational transition in Bordetellapertussis immunoglobulinMOPC 460, 3549 Extracytoplasmicadenylate cyclase of Bordetellapertussis, 1926 Low resolutionmodel for 50S subunit of Escherichiacoli ribosomes, Botany 2379 Euglena chloroplasttRNAs: Transcriptional origin, 1984 Molecularmechanism of inhibitionof firefly luminescenceby local Growthconditions influence number of chloroplastDNA moleculesin anesthetics,481 Euglena gracilis, 2401 Molecularweights determined by fluctuationspectroscopy: Application Hydrogenevolution affects efficiencyof nitrogenfixation in nodulated to DNA, 2776 symbionts,1207 Nuclearmagnetic resonance studies of interactionof generalanesthetics Localizationof phytochromein etioplasts and its regulationin vitro of with 1,2-dihexadecyl-sn-glycero-3-phosphorylcholinebilayer, 3999 gibberellinlevels, 138 Postreplicationrepair enhanced in Chinesehamster cells, 2396 Metabolicindicator of photoperiodictiming, 501 Pro-Leu-Gly-NH2conformation, 1203 Neoplasticstate suppressedwith acquisitionof specializedfunctions in Proton relaxationand chargeaccumulation during oxygen evolutionin cells, tissues, and organsof crowngall teratomasof tobacco,496 photosynthesis,1196 Path of electronsin photosynthesis,4502 Rate of quaternarystructure change in hemoglobinmeasured by Recoveryof crowngall tumorcells, 3562 modulatedexcitation, 4497 Reserveprotein metabolism in cotyledonsof mung bean seedlings,3168 Responsesof Phycomycesindicating optical excitationof lowest triplet Serinolas an activatorof toxin productionin attenuatedcultures of state of riboflavin,1969 Helminthosporiumsacchari, 4007 Sequence-specificrecognition of double helical nucleic acids by proteins, Boundarycondition 804 Inverseproblem for convex bodies, 1377 Solid tumor models for assessment of different treatment modalities: Brachinus Systematics of response to radiotherapy and chemotherapy, 818 Ploy and counterployin predator-preyinteractions: Orb-weaving spiders Somatostatin conformation: Stable intramolecular structure by circular versusbombardier beetles, 1365 dichroism,diffusion, and sedimentationequilibrium, 1199 Bradykinin Structure-functionrelations in hemoglobinas determinedby x-ray Prekallikreinand high-molecular-weightkininogen: A complexin human absorptionspectroscopy, 491 plasma,4179 Temperaturedependence of four ionic processesof spike electrogenesis ProstaglandinE synthesis in culturedhuman umbilical vein smooth in eel electroplaques,3554 muscle cells, 1617 Transientchange in Na ion conductivityof excitablemembranes, 4492 Brain X-ray diffractionof actively shorteningmuscle, 813 see also Caudatenucleus; Cell, brain;Cerebellum; Cerebral cortex; Biosynthesis, error rate in Cerebraltissue; Hypothalamus Kinetic proofreadingin amino acylationof tRNAIle,1164 Downloaded by guest on October 5, 2021 4724 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Choline synthesized from ethanolamine in rat brain, 2181 Calcium-dependentregulatory protein Clathrin: Protein associated with intracellular transfer of membrane by Calcium-dependentregulatory protein of cyclic nucleotidemetabolism in coated vesicles, 1255 normaland transformedchicken embryo fibroblasts, 2711 Dopamine receptors in human and calf brains, using [3H]apomorphine Calciumgate and an antipsychotic drug, 4354 Presynapticcalcium currents and relationto synaptictransmission: /-Lipotropin: Prohormone for morphinomimetic peptides endorphins Voltageclamp study in squid giant synapseand theoreticalmodel for and enkephalins, 2156 calciumgate, 2918 Metabolic mapping of primary visual system of monkey by Calcium-sensitivedye autoradiographic [14C]deoxyglucose technique, 4230 Membraneperturbation: Calcium-sensitive dye, arsenazoIII, used in Morphine-like peptides in mammalian brain: Isolation, structure liposomes,510 elucidation, and interactions with opiate receptor, 2515 Calorimetry Neurofilament protein localized in neuroblastoma cells by Calorimetricstudies of in vitro polymerizationof braintubulin, 3565 immunofluorescent staining, 3192 Camphormonooxygenase Opiate receptor: Autoradiographic localization in rat brain, 3729 Thermodynamicmodel of regulation:Modulation of redox equilibriain Triiodothyronine localized in nerve ending fractions of rat brain, 941 camphormonoxygenase, 1078 Brain filament Cancer Biochemistry of filaments of brain, 529 see also Carcinogenesis;specific cancers;specific cell cultures;specific Branch migration cells Kinetics of branch migration in double-stranded DNA, 2299 Antibody-producingcells: Virus-inducedalteration of responseto Bulawayan stromatolite antigen, 1707 Fossil microorganisms from 2800 to 2500 million-year-old Bulawayan BK virus DNA occursin DNA obtainedfrom certain humantumors, stromatolite: Ultramicrochemical analyses, 2973 4662 Bungarotoxin Cancer-associatedisoenzyme of serumgalactosyltransferase, 1319 Acetylcholine receptors: Localization during synaptogenesis in retina, Carcinogensas mutagensin Salmonella/microsometest: Assay of 300 1806 chemicals,950 l-Bungarotoxin, pre-synaptic toxin with enzymatic activity, 178 Do highly oncogenicgroup A humanadenoviruses cause humancancer? Lateral motion of fluorescently labeled acetylcholine receptors in Analysisof humantumors for adenovirus12 transformingDNA membranes of developing muscle fibers, 4594 sequences,4657 Mechanism of action of 0f-bungarotoxin on synaptosomal preparations, Elevatedserum ribonuclease in patients with pancreaticcancer, 2308 2664 y-Glutamyltranspeptidase, a lymphoidcell-surface marker: Relationship Burkitt's lymphoma to blastogenesis,differentiation, and neoplasia,2414 Alkaline phosphatase activity in lymphocyte, mitogen-induced blasts, Hormoneresponsive human breast cancer in long-termtissue culture: lymphoblastoid cell lines, acute myeloid leukemia, and chronic Effect of insulin, 4536 lymphatic leukemia cells, 1432 Inhibitorof DNA synthesis isolated specific for normaland malignant Surface marker characteristics and Epstein-Barr virus studies of two mammarycells, 2196 established North American Burkitt's lymphoma cell lines, 228 In vivo rates of methioninebiosynthesis in transformedhuman and Butaclamol malignantrat cells auxotrophicfor methionine,1523 Dopamine receptors in human and' calf brains, using [3H]apomorphine Isolationfrom patients with breast cancerof antibodiesspecific for and an antipsychotic drug, 4354 antigensassociated with breastcancer and other malignantdiseases, 2101 Murinetype-C RNA virogenessuppressed by type-specificoncornavirus vaccines:Prospects for preventionof cancer,620 Rheumatoidfactor and tumor-hostinteraction, 2106 Cadmium Supplementalascorbate in supportivetreatment of cancer:Prolongation Amino-acid sequence of equine renal metallothionein-lB, 3413 of survivaltimes in terminalhuman cancer, 3685 Caecilian Tumorcell proliferationinhibited by dimerizedribonuclease, 573 Caecilian ear, 3744 Cannibalism Calcitonin Selective cannibalismin rotiferAsplanchna sieboldi: Contact recognition Distribution of calcitonin-sensitive adenylate cyclase activity along of morphotypeand clone, 3233 rabbit kidney tubule, 3608 Cap formation Calcium Nucleus-membraneinteraction in cappingof surfacemembrane Ability of insulin to increase calcium binding by adipocyte plasma receptors,4580 membranes, 1542 Carassius auratus ATP binding to protease-resistant core of actin, 2742 Phylogeneticorigins of immunerecognition: Lymphocyte surface Ca2+ and adenylate and guanylate cyclases in control of platelet immunoglobulins in goldfish, Carassius auratus, 2476 secretion and aggregation, 1829 Caratheodory differential metric Calcium binding in cerebral tissue: Sensitivity to weak environmental Completenessof Bergmanmetric and its subordinatemetric, 4294 electric fields oscillating at low frequency, 1999 Carbamoylphosphate synthetase, glutamine-dependent Calcium control of actin-activated myosin adenosine triphosphatase from Enzyme-boundactivated CO2 is carbonic-phosphoricanhydride: Dictyostelium discoideum, 2321 Isolationof correspondingtrimethyl derivative from active site of Control of renal vitamin D hydroxylases in birds by sex hormones, 2701 glutamine-dependentcarbamyl phosphate synthetase, 3020 Cross inhibitory interactions of potential mediators of hormone and Carbohydrate neurotransmitter action, 2982 Kineticsof glucagonin man:Effects of starvation,1735 Development of action potential mechanism of amphibian neurons Carbohydrate, surface-membrane isolated in culture, 1641 Surfacemembrane carbohydrate alterations of flagellatedprotozoan Different calcium requirements for proliferation of conditionally and mediatedby bacterialendosymbiotes, 852 unconditionally tumorigenic mouse cells, 1651 Carbondioxide Does somatostatin inhibition of insulin secretion involve two Renal CO2production from glutamineand lactate as functionof arterial mechanisms of action? 248 perfusionpressure in dog, 4235 Dynamic properties of isolated acetylcholine receptor proteins: Release Carbon dioxide, activated of calcium ions caused by acetylcholine binding, 3364 Enzyme-boundactivated CO2 is carbonic-phosphoricanhydride: Elimination of rotating carrier mechanism for active transport of Ca ion Isolationof correspondingtrimethyl derivative from active site of in sarcoplasmic reticulum membranes, 1532 glutamine-dependentcarbamyl phosphate synthetase, 3020 Force-velocity characteristics for calcium-activated mammalian Carbonic-phosphoricanhydride slow-twitch and fast-twitch skeletal fibers from the guinea pig, 4693 Enzyme-boundactivated CO2 is carbonic-phosphoricanhydride: Intrinsic transglutaminase in Ca2+-mediated crosslinking of erythrocyte Isolationof correspondingtrimethyl derivative from active site of proteins, 4479 glutamine-dependentcarbamyl phosphate synthetase, 3020 Ion distribution in subcellular myocardial particulates separated by Carbonmonoxide density gradient centrifugation with nonpolar liquid under ion Anaerobic growth of a Rhodopseudomonoas species in dark with carbon immobilization conditions, 1754 monoxideas sole carbonand energysubstrate, 3298 Iso(',eod-ctv-lchlinie receptor protein: Kinetics of binding of Carbonmonoxide binding to pentacoordinatemercaptide-heme .At,. '. !li. .:l:l;:: ?l , (': ions, 3994 complexes:Kinetic study on models for cytochromeP-450, 3338 Mutual potentiation by magnesium and calcium of growth in animal Nature of 02 and CO binding to metalloporphyrins and heme proteins, cells, 168 3333 Myosin-mediated Ca++-regulaton of Carbonyl molecule actomyosin-adenosinetriphosphatase from porcine aorta, 2706 Magnetic circular dichroism of molecules in dense media: Spin-forbidden Proliferation of Rous sarcoma virus-infected, but not of normal, chicken transitions of carbonyl molecules, 2964 fibroblasts in oxygen-enriched environment, 1265 Carboxyglutamicacid Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells, 2520 -y-Carboxyglutamic acid-containing protein from bone, 1447 Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells --Carboxyglutamic acid-containing protein from bovine bone: Primary (correction), 4247 structure, 3374 Tropomyosin-binding component of rabbit skeletal muscle troponin: Carboxylgroup Amino-acid sequence, 1902 Hen egg-white lysozyme: Individual carboxyl groups seen by high field Tropomyosin-binding component of rabbit skeletal muscle troponin: nuclear magnetic resonance, 1979 Amino-acid sequence (correction), 4711 Carboxypeptidase Calcium-bindingprotein Homologous inhibitors from potato tubers of serine endopeptidases and Regulation of dopamine stimulation of striatal adenylate cyclase by an metallocarboxypeptidases, 1941 endogenous Ca++-binding protein, 3887 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4725

Carboxypeptidase A (EC 3.4.12.2) Catalytic hydrogenation Mechanism of action of carboxypeptidase A in ester hydrolysis, 3882 Modulation of membrane fluidity: Homogeneous catalytic hydrogenation Carcinoembryonic antigen of phospholipids and phospholipid-water model biomembranes, 3971 see also Antigen, embryonal carcinoma Cataract Immunological crossreaction between alpha-fetoprotein and albumin, Absence of low-molecular-weight alpha crystallin in nuclear region of old 4641 human lenses, 3484 Immunological crossreactivity of antibodies to synthetic undecapeptide Catecholamine analogous to amino-terminal segment of carcinoembryonic antigen, see also Receptor, catecholamine with intact protein and with human sera, 2123 Bandage-backfall reaction: Occurs in infancy, hypothalamic damage, and Carcinogenesis, chemical catalepsy, 3311 see also Hydrocarbon, polycyclic, carcinogenic; specific chemicals Biological activity of catecholamines covalently linked to synthetic Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse polymers: Immobilized drug theory, 1009 skin, 243 Biological activity of catecholamines covalently linked to synthetic Carcinogens as mutagens in Salmonella/microsome test: Assay of 300 polymers: Immobilized drug theory (correction), 2939 chemicals, 950 Catecholamine-stimulated cyclic GMP accumulation in rat pineal: Detection of different types of damage in alkylated DNA by human Apparent presynaptic site of action, 3398 corrective endonuclease (correndonuclease), 2629 Desensitization of 1-adrenergicreceptors by 3-adrenergic agonists in (+)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[aJpyrene: Potent skin cell-free system: Resensitization by guanosine carcinogen when applied topically to mice, 3867 5'-(l,-y-imino)triphosphate and other purine nucleotides, 1494 ( + )-7,8/-Dihydroxy-93, 10l3-epoxy-7,8,9,10-tetrahydrobenzo[a] pyrene is Hormone and neurotransmitter receptors in established vascular an intermediate in metabolism and binding to DNA of benzo[a]pyrene, endothelial cell line, 1612 2679 Noradrenergic clonal line of rat adrenal pheochromocytoma cells Endonuclease II, apurinic acid endonuclease, and exonuclease III, 4324 established which respond to nerve growth factor, 2424 Enzymatic conversion of benzo[a]pyrene leading predominantly to the Subcellular distribution of protein carboxymethylase and its endogenous diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo- substrates in adrenal medulla: Role in excitation-secretion coupling, [a]pyrene through a single enantiomer of 4050 r-7,t-8-dihydroxy-7,8-dihydrobenzo[a]pyrene, 2594 Triiodothyronine localized in nerve ending fractions of rat brain, 941 Enzyme catalyzed covalent binding of benzo[a]pyrene to poly(G), 1117 Caudate nucleus High blood pressure related to carcinogen-induced unscheduled DNA Dopamine receptors in human and calf brains, using [3H]apomorphine synthesis, DNA carcinogen binding, and chromosomal aberrations in and an antipsychotic drug, 4354 human lymphocytes, 2496 Caulobacter crescentus Metabolic activation of aromatic hydrocarbons in purified rat liver 3':5'-Cyclic GMP derivatives: Effect on formation of Caulobacter surface nuclei: Induction of enzyme activities and binding to DNA with and structures, 3303 without monooxygenase-catalyzed formation of active oxygen, 457 Celiac disease Metabolism of benzo[a]pyrene: Conversion of Gliadin protein components: Relationship to chromosomes in hexaploid (+) -trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly wheats (Triticum aestivum L.), 3646 mutagenic 7,8-diol-9,10-epoxides, 3381 Cell Mutagenicity of aflatoxins related to their metabolism and carcinogenic see also Cell culture potential, 2241 Cell adhesion Mutagenic metabolites of benzo[a]pyrene identified in mammalian cells, Active cell edge and movements of concanavalin A receptors of surface of 607 epithelial and fibroblastic cells, 4085 Prevention of viral-chemical co-carcinogenesis in vitro by type-specific Adhesion among cells from neural tissues of chick embryo, 577 anti-viral antibody, 152 Cell surface protein partially restores morphology, adhesiveness, and Prophage X induction in Escherichia coli K12 envA uvrB: Sensitive test contact inhibition of movement to transformed fibroblasts, 1217 for potential carcinogens, 3700 Gradient of adhesive specificity in developing avian retina, 410 Structure of 7,12-dimethylbenz[a]anthracene-guanosine adducts, 2311 Cell, adipose Synthesis of nuclear proteins during DNA repair synthesis in human Conversion of 3T3 fibroblasts into adipose cells: Triggering of diploid fibroblasts damaged with ultraviolet radiation or differentiation by prostaglandin F2,, and 1-methyl-3-isobutyl xanthine, N-acetoxy-2-acetylaminofluorene, 1466 4516 Carcinogenesis, viral Cell agglutination Prevention of viral-chemical co-carcinogenesis in vitro by type-specific Human lymphocyte stimulation by concanavalin A: Role of valence and anti-viral antibody, 152 surface binding sites, 2118 Carcinoma, embryonal Monovalent derivatives of concanavalin A, 790 Totipotency and normal differentiation of single teratocarcinoma cells Cell aggregation cloned by injection into blastocysts, 549 Acrasin of cellular slime mold Polysphondylium violaceum, 795 Cardiac tissue Retina-specific cell-.f.nre.atin. factor isolated from membranes of Phosphorus nuclear magnetic resonance studies on normoxic and embryonic neural 't.'i i i;i i--ii, 3594 ischemic cardiac tissue, 4446 Cell, brain Cardiotoxicity Adhesion among cells from neural tissues of chick embryo, 577 Bioenergetics in clinical medicine: Prevention by forms of coenzyme Q of Cell, chick inhibition by adriamycin of coenzyme Qo1-enzymes in mitochondria of Insulin effect on cell cycle: Kinetics of growth parameters in confluent myocardium, 4653 chick cells, 3173 Cardiovascular disease Cell, chick embryo Phosphorus nuclear magnetic resonance studies on normoxic and Quantitation of b-crystallin messenger RNA during lens induction in ischemic cardiac tissue, 4446 chick embryos, 2808 Carotene diode Cell, chick embryo tendon, matrix-free Path of electrons in photosynthesis, 4502 Carbohydrate moieties of procollagen: Incorporation of isotopically Carotenoid pigment labeled mannose and glucosamine into propeptides of procollagen Photoprotection by carotenoid pigments in copepod Diaptomus secreted by matrix-free chick embryo tendon cells, 34 nevadensis, 971 Cell, Chinese hamster Carrier protein, lac Mutability of different genetic loci in mammalian cells by metabolically Energy-dependent binding of dansylgalactoside to lac carrier protein: activated carcinogenic polycyclic hydrocarbons, 188 Direct binding measurements, 109 Postreplication repair enhanced in Chinese hamster cells, 2396 Cartilage Cell, Chinese hamster lung Amplification of moderately repetitive DNA sequences during chick Resting state in normal and simian virus 40 transformed Chinese cartilage differentiation, 3428 hamster lung cells, 1655 5-Bromodeoxyuridine and thymidine distribution in DNA of developing Cell, Chinese hamster ovary chick cartilage, 1019 Switches in polarity of chromosomal DNA, 877 Growth of transplanted tails of infant rats in adolescent allogeneic Cell, clonal myogenic recipients, 3283 Phenotypic transformation of clonal myogenic cells to cells resembling Nonsuppressible insulin-like activity and thyroid hormones: Major chondrocytes, 1989 pituitary-dependent sulfation factors for chick embryo cartilage, 2904 Cell culture, adrenal pheochromocytoma Catabolite modulator factor Noradrenergic clonal line of rat adrenal pheochromocytoma cells Catabolite modulator factor: Mediator of catabolite repression in established which respond to nerve growth factor, 2424 bacteria, 3476 Cell culture, bone marrow Catabolite repression Fetal hemoglobin synthesis stimulated in bone marrow cultures from Catabolite modulator factor: Mediator of catabolite repression in adult individuals, 2033 bacteria, 3476 Cell culture, calf muscle Catalase monolayer Protein synthesis and actin heterogeneity in calf muscle cells in culture, Catalase monolayers inactivated by irradiation with 100 keV electrons, 2018 823 Cell culture, Chinese hamster Catalepsy 5-Bromodeoxyuridine-DNA strand symmetry and repair of photolytic Bandage-backfall reaction: Occurs in infancy, hypothalamic damage, and breaks in Chinese hamster cell chromosomes, 3905 catalepsy, 3311 Cell culture, endothelial Catalysis Characterization of collagen synthesized by endothelial cells in culture, Metal cluster in catalysis: Hydrocarbon reactions, 4274 2361 Modulation of membrane fluidity: Homogeneous catalytic hydrogenation Hormone and neurotransmitter receptors in established vascular of phospholipids and phospholipid-water model biomembranes, 3971 endothelial cell line, 1612 Downloaded by guest on October 5, 2021 4726 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Cell culture, erythroleukemia Lymphocyte stimulation: Rapid multiparameter analysis, 2881 Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in Quantized generation time in mammalian cells as expression of cellular tissue cultures of rat erythroleukemia cells transformed by , 4012 7,12-dimethylbenz(a)anthracene, 1237 Resting state in normal and simian virus 40 transformed Chinese Erythroid cell differentiation: Murine erythroleukemia cell variant with hamster lung cells, 1655 unique pattern of induction by polar compounds, 1232 Yeast : Synthesis in cell cycle, 1863 Cell culture, fibroblast Cell, D- Alterations in cell surface glycosphingolipids and other lipid classes of Hypertrophy and hyperplasia of somatostatin-containing D-cells in fibroblasts in familial hypercholesterolemia, 4339 diabetes, 1338 Enveloped virus acquires membrane defect when passaged in fibroblasts Cell damage from I-cell disease patients, 2443 Radiation effects in living cells: Structural model, 3360 Polypeptide of 18,000 molecular weight induces early events and Cell division stimulates DNA synthesis in cultured cells, 4555 Changes in type of collagen synthesized as clones of chick chondrocytes Proliferation of Rous sarcoma virus-infected, but not of normal, chicken grow and lose division capacity, 1674 fibroblasts in oxygen-enriched environment, 1265 Cloning of Escherichia coli DNA that controls cell division and capsular Relationship between in vitro cellular aging and in vivo human age, 3584 polysaccharide synthesis, 697 Cell culture, heart Control of cell division in Saccharomyces cerevisiae by methionyl-tRNA, Innervation of heart cells in culture by endogenous source of cholinergic 1664 neurons, 4506 Morphogenesis of bacterial division septum: Class of septation-defective Cell culture, hepatoma mutants, 1882 a-Methylornithine, potent competitive inhibitor of ornithine Cell, endocrine decarboxylase, blocks proliferation of rat hepatoma cells in culture, Vasoactive intestinal polypeptide localized to central and peripheral 1626 neurons, 3197 Vitamin K-dependent synthesis and modification of precursor Cell, epithelial prothrombin in cultured H-35 hepatoma cells, 2803 Active cell edge and movements of concanavalin A receptors of surface of Cell culture, human breast cancer epithelial and fibroblastic cells, 4085 Hormone responsive human breast cancer in long-term tissue culture: Cell, epithelial nasopharyngeal carcinoma Effect of insulin, 4536 Epithelial nasopharyngeal carcinoma cells superinfected with Cell culture, kidney Epstein-Barr virus, 960 Biphasic stimulation of polyamine biosynthesis in primary mouse kidney Cell, erythroid cells by infection with polyoma virus: Uncoupling from DNA and Fetal hemoglobin synthesis stimulated in bone marrow cultures from rRNA synthesis, 4022 adult individuals, 2033 Reversion from transformed to normal phenotype by inhibition of Cell, erythroleukemia protein synthesis in rat kidney cells infected with Potent of differentiation in murine erythroleukemia cells, 862 temperature-sensitive mutant of Rous sarcoma virus, 3603 Cell fractionation Cell culture, liver Fatty acyl-CoA oxidizing system in rat liver peroxisomes: Enhancement Induction and decay of glucagon-induced amino acid transport in by clofibrate, a hypolipidemic drug, 2043 primary cultures of adult rat liver cells: Paradoxical effects of Subcellular localization of S-adenosyl-L-methionine:tRNA cycloheximide and puromycin, 4511 methyltransferases with aminoacyl-tRNA synthetases in human and Cell culture, lymphoid mouse: Normal and leukemic leukocytes, 3857 Interferon treatment of mice: Enhanced expression of histocompatibility Cell, Friend antigens on lymphoid cells, 1284 Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in Cell culture, macrophage tissue cultures of rat erythroleukemia cells transformed by Phagosome-lysosome fusion in cultured macrophages prevented by 7,12-dimethylbenz(a)anthracene, 1237 sulfatides of Mycobacterium tuberculosis, 2510 Erythroid cell differentiation: Murine erythroleukemia cell variant with Secretion of macrophage neutral proteinase enhanced by colchicine, 872 unique pattern of induction by polar compounds, 1232 Cell culture, mammalian Cell fusion Antigens and antibodies crossreactive with type C viruses of woolly Coupling of catecholamine receptor from one cell with adenylate cyclase monkey and gibbon ape in animal models and in humans, 1725 from another cell by cell fusion, 4410 Cytoplasmic microtubules in tissue culture cells appear to grow from Fusion of bacterial protoplasts, 2151 organizing structure towards plasma membrane, 867 Fusion of protoplasts of Bacillus megaterium, 2147 DNA strand breaks, repair, and survival in x-irradiated mammalian cells, Long-chain neutral glycolipids and gangliosides of murine fibroblast 809 lines and their low- and high-tumorigenic hybrids, 1568 Isolation and characterization of unsaturated fatty acid-requiring mutant Cell genetics, somatic mammalian of cultured mammalian cells, 24 5-Bromodeoxyuridine-DNA strand symmetry and repair of photolytic Quantized generation time in mammalian cells as expression of cellular breaks in Chinese hamster cell chromosomes, 3905 clock, 4012 Genetics of somatic mammalian cells: Genetic, immunologic, and Cell culture, muscle biochemical analysis with Chinese hamster cell hybrids containing Synthesis of polypeptides with properties of myosin light chains directed selected human chromosomes, 193 by RNA extracted from muscle cultures, 4599 Cell, glial Cell culture, pituitary Reversible in vitro polymerization of tubulin from cultured cell clone Dose-dependent depletion of nuclear receptors by L-triiodothyronine: (rat glial cell clone C6), 1227 Role in induction of growth hormone synthesis in cultured GH1 cells, Cell growth 3877 Amino-terminal sequences of two polypeptides from human serum with Thyroid hormone stimulates de novo growth hormone synthesis in nonsuppressible insulin-like and cell-growth-promoting activities: cultured GH1 cells: Accumulation of rate limiting RNA species in Structural homology with insulin B chain, 4379 induction, 3369 Growth of human diploid fibroblasts in absence of glucose utilization, Cell culture, renal epithelium 4110 Transepithelial transport in cell culture, 1212 Cell, HeLa Cell culture, smooth muscle Analysis of HeLa cell hypoxanthine phosphoribosyltransferase mutants Prostaglandin E synthesis in cultured human umbilical vein smooth and revertants by two-dimensional polyacrylamide gel electrophoresis: muscle cells, 1617 Silent gene activation, 4589 Cell culture, 3T3 Incorporation of 5-fluorocytidine in RNA of 5-fluorouracil-treated Different calcium requirements for proliferation of conditionally and eukaryotic cells, 1528 unconditionally tumorigenic mouse cells, 1651 Poliovirus-induced inhibition of polypeptide initiation in vitro on native Lipid vesicles as carriers for introducing materials into cultured cells: polyribosomes, 1834 Influence of vesicle lipid composition on mechanism(s) of vesicle Temporal relationships of chromatin protein synthesis, DNA synthesis, incorporation into cells, 1603 and assembly of deoxyribonucleoprotein, 2270 Sodium-stimulated amino acid uptake into isolated membrane vesicles Cell, hepatoma from Balb/c 3T3 cells transformed by simian virus 40, 1631 Cellular cholesterol ester accumulation induced by free cholesterol-rich Cell culture, tumor lipid dispersions, 3680 Cultured tumor cells: Affinity isolation by drugs and hormones Clonal variation in albumin messenger RNA activity in hepatoma cells, covalently bound to glass and Sepharose beads, 2013 2056 Cell culture, Xenopus laevis Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Development of action potential mechanism of amphibian neurons hepatoma cells grown in vivo and n vitro, 2735 isolated in culture, 1641 Cell hybrid Cell cycle see Hybrid cell Activity of yeast extracts in cell-free stimulation of DNA replication, Cell, L 3933 Chromosome-mediated gene transfer between closely related strains of Cell cycle analysis and X-chromosome inactivation in developing mouse, cultured mouse cells, 2838 1608 Interferon-induced inhibition of protein synthesis in L-cell extracts: Human chromosome 3 releases block at G1 of cell cycle, in hybrids ATP-dependent step in activation of inhibitor by double-stranded between tsAF8 hamster and human cells, 2052 RNA, 3136 Initiation of replication in chromosomal DNA induced by extracts from Cell, leukemic proliferating cells, 2231 Ia-like molecules on surface of normal and leukemic human cells, 1288 Insulin effect on cell cycle: Kinetics of growth parameters in confluent Modifications of purified glucose-6-phosphate dehydrogenase and other chick cells, 3173 enzymes by a factor of low molecular weight abundant in some leukemic cells, 77 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4727

Tandem integration of avian myeloblastosis virus DNA with endogenous Retina-specific cell-aggregating factor isolated from membranes of provirus in leukemic chicken cells, 1749 embryonic neural retina tissue, 3594 Cell, lymphaticleukemia Specificity of synapse formation, 3544 Alkaline phosphatase activity in lymphocyte, mitogen-induced blasts, Synapse formation between clonal neuroblastoma x glioma hybrid cells lymphoblastoid cell lines, acute myeloid leukemia, and chronic and striated muscle cells, 123 lymphatic leukemia cells, 1432 Cell replication Cell, lymphoblastoid Decreased fidelity of DNA polymerase activity isolated from aging Alkalinephosphatase activity in lymphocyte,mitogen-induced blasts, . human fibroblasts, 2818 lymphoblastoid cell lines, acute myeloid leukemia, and chronic Deposition of histone onto replicating chromosome: Newly synthesized lymphatic leukemia cells, 1432 histone is not found near replication fork' 2266 Cell, lymphoma Replicating cells cluster in aortic endothelium, 651 Clathrin: Protein associated with intracellular transfer of membrane by Cell, retinal coated vesicles, 1255 Adhesion among cells from neural tissues of chick embryo, 577 Cell, mammalian Retina-specific cell-aggregating factor isolated from membranes of Diadenosine 5',5"'-Pl,p4-tetraphosphate (Ap4A) in mammalian cells in embryonic neural retina tissue, 3594 levels varying widely with proliferative activity of tissue: Possible Cell, rheumatoidsynovial positive "pleiotypic activator", 3984 Collagenaseand prostaglandinsproduced by isolated adherent Cell, mammary rheumatoid synovial cells, 945 Inhibitor of DNA synthesis isolated specific for normal and malignant Cell secretion mammary cells, 2196 Subcellular distribution of protein carboxymethylase and its endogenous Cell, mast substrates in adrenal medulla: Role in excitation-secretion coupling, Freeze-fracture study of mast cell secretion, 2823 4050 Cell-mediatedresponse Cell, somatic Antigen stimulation of prostaglandin synthesis and control of immune Chromosome-mediated gene transfer between closely related strains of responses, 1300 cultured mouse cells, 2838 Cell, melanoma Transfer of tRNAs to somatic cells mediated by Sendai-virus-induced Cell surface receptors for melanotropin associated with Golgi region in fusion, 2793 mouse melanoma cells, 559 Cell, suppressor Cell metabolism Aplastic anemia: Presence in human bone marrow of cells that suppress Relation between oxidative metabolism and slow rhythmic potentials in myelopoiesis, 2890 mammalian intestinal muscle, 4239 Cell surface Cell, monkeykidney see also Antigen, cell surface; Receptor, cell surface Segment of simian virus 40 genome containing origin of DNA replication: Active cell edge and movements of concanavalin A receptors of surface of Isolation and propagation, 1513 epithelial and fibroblastic cells, 4085 Cell, mononuclearwhite Differential labeling of cell surface of single ciliary ganglion neurons in Electrophoretic distributions of human peripheral blood mononuclear vitro, 4100 white cells from normal subjects and from patients with acute Lipid vesicles as carriers for introducing materials into cultured cells: lymphocytic leukemia, 2388 Influence of vesicle lipid composition on mechanism(s) of vesicle Cell morphology incorporation into cells, 1603 Microfilament organization and surface topography: Changes upon Long-chain neutral glycolipids and gangliosides of murine fibroblast transformation of chick embryo fibroblasts with Rous sarcoma virus, lines and their low- and high-tumorigenic hybrids, 1568 4065 Cell surfacemacromolecule Structural (shape-maintaining) role of cell surface glycoprotein of Magnetic resonance studies of concanavalin A: Binding site of Halobacterium salinarium, 2687 a-methyl-D-mannopyranoside, 322 Cell morphotype Cell surfaceorganization Selective cannibalism in rotifer Asplanchna sieboldi: Contact recognition Helical growth of Bacillus subtilis: Model of cell growth, 1740 of morphotype and clone, 3233 Cell surface,protein Cell, mouse Adhesion among cells from neural tissues of chick embryo, 577 Mismatched base-pair regions in polyoma heteroduplex DNA: Fate Cell surface protein partially restores morphology, adhesiveness, and during infection of mouse cells, 3073 contact inhibition of movement to transformed fibroblasts, 1217 Mouse A9 cell clones differing in malignancy derived in vitro: Analysis Y-Glutamyl transpeptidase, a lymphoid cell-surface marker: Relationship by somatic cell hybridization with YACIR lymphoma cell clones, 2004 to blastogenesis, differentiation, and neoplasia, 2414 Cell, mouse A9 Mutants of Balb/c 3T3 fibroblasts defective in adhesiveness to Mouse A9 cell clones differing in malignancy derived in vitro: Analysis substratum: Alteration in cell surface proteins, 544 by somatic cell hybridization with YACIR lymphoma cell clones, 2004 Structural (shape-maintaining) role of cell surface glycoprotein of Cell movement Halobacterium salinarium, 2687 Calcium control of actin-activated myosin adenosine triphosphatase from Tumor induction and large external transformation sensitive protein on Dictyostelium discoideum, 2321 cell surface, 3570 Cell, Muller Cell synchrony Muller cell function during spreading depression in frog retina, 1351 Resting state in normal and simian virus 40 transformed Chinese Cell, muscle hamster lung cells, 1655 Immunological characterization of subunit of 100 A filaments from Cell, 3T3 muscle cells, 4344 Control of growth of.benzo[a]pyrene-transformed 3T3 cells, 3229 Cell mutant Conversion of 3T3 fibroblasts into adipose cells: Triggering of Isolation and characterization of unsaturated fatty acid-requiring mutant differentiation by prostaglandin F2,, and 1-methyl-3-isobutyl xanthine, of cultured mammalian cells, 24 4516 Cell, neoplastic Regulation of guanylate and adenylate cyclase activities by lysolecithin, Initiation of replication in chromosomal DNA induced by extracts from 1586 proliferating cells, 2231 Cell, teratocarcinoma Temperature-sensitive changes in surface modulating assemblies of Totipotency and normal differentiation of single teratocarcinoma cells fibroblasts transformed by mutants of Rous sarcoma virus, 2047 cloned by injection into blastocysts, 549 Cell, neuroblastoma Cellularclock Maturation of neuroblastoma cells in presence of dimethylsulfoxide, 462 Quantized generation time in mammalian cells as expression of cellular Membrane potential dependent binding of scorpion toxin to action clock, 4012 potential Na+ ionophore, 2682 Cellulose Neurofilament protein localized in neuroblastoma cells by Cellulose biosynthesis in Acetobacter xylinum: Visualization of site of immunofluorescent staining, 3192 synthesis and direct measurement of in vivo process, 4565 Cell, Novikoffhepatoma Cellulose microfibrils: Visualization of biosynthetic and orienting Fetal protein in chromatin of Novikoff hepatoma and Walker 256 complexes in association with plasma membrane, 143 carcinosarcoma tumors that is absent from normal and regenerating Cell, vascular endothelial rat liver, 3258 Clonal growth of bovine vascular endothelial cells: Fibroblast growth Cell, oxyntic factor as survival agent, 4120 Actin-like filaments and membrane rearrangement in oxyntic cells, 4032 Cell wall Cell, pancreaticacinar Oligomeric intermediate in peptidoglycan biosynthesis in Bacillus Cellular cyclic nucleotides and enzyme secretion in pancreatic acinar cell, megaterium, 4200 156 Cell wall formation Cell proliferation Chitiri biosynthesis during Blastocladiella zoospore germination: Different calcium requirements for proliferation of conditionally and Hexosamine biosynthetic pathway is post-translationally activated unconditionally tumorigenic mouse cells, 1651 during cell differentiation, 534 Effects of concanavalin A and succinylated derivative on lymphocyte Centralnervous system proliferation and cyclic nucleotide levels, 1717 Antibodiesas a means of isolatingand characterizingbiologically active Proliferation of Rous sarcoma virus-infected, but not of normal, chicken substances: Nonpeptide, morphine-like compound in central nervous fibroblasts in oxygen-enriched environment, 1265 system, 2132 Tumor cell proliferation inhibited by dimerized ribonuclease, 573 Centrosphere Cell recognition Cytoplasmic microtubules in tissue culture cells appear to grow from Cell recognition in plants: Determinants of stigma surface and pollen organizing structure towards plasma membrane, 867 interactions, 2788 Downloaded by guest on October 5, 2021 4728 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Ceramidedecasaccharide Nature of 02 and CO binding to metalloporphyrins and heme proteins, Long-chain neutral glycolipids and gangliosides of murine fibroblast 3333 lines and their low- and high-tumorigenic hybrids, 1568 15N nuclear magnetic resonance investigations on amino acids, 1409 Cerebellardevelopment Nuclear magnetic resonance description of molecular motion and phase Purkinje cell degeneration, neurological mutation in mouse, 208 separations of cholesterol in lecithin dispersions, 3812 Cerebellum Nuclear magnetic resonance studies of helix-coil transition of Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells, 2520 poly(dA-dT) in aqueous solution, 674 Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells Nuclear magnetic resonance studies of slowly exchanging peptide (correction), 4247 protons in cytochrome c in aqueous solution, 1398 Cerebralcortex Platinum binds selectively to phosphorothioate groups in mono- and Cytoarchitectonic mapping by microdensitometry, 2928 polynucleotides: General method for heavy metal staining of specific Cerebraltissue nucleotides, 2536 Calcium binding in cerebral tissue: Sensitivity to weak environmental Polymerization of deoxygenated sickle cell hemoglobin: Thermodynamic electric fields oscillating at low frequency, 1999 studies, 990 Chalone Prediction of three-dimensional structures of enzyme-substrate and Inhibitor of DNA synthesis isolated specific for normal and malignant enzyme-inhibitor complexes of lysozyme, 4261 . mammary cells, 2196 Rapid-flow resonance Raman spectroscopy of photolabile molecules: Characeanalga Rhodopsin and isorhodopsin, 1 Polarity of actin filaments in Characean algae, 165 Resonance enhanced coherent anti-Stokes Raman scattering, 3798 Chargeaccumulation Retinal has highly dipolar vertically excited singlet state: Implications Proton relaxation and charge accumulation during oxygen evolution in for vision, 2169 photosynthesis, 1196 Screening by negative chemical ionization mass spectrometry for Charge-transferinteraction environmental contamination with toxic residues: Application to Crystal structure of complex between lumiflavin and human urines, 1777 2,6-diamino-9-ethylpurine: Flavin adenine dinucleotide model Separation of hydrogenase-catalyzed hydrogen-evolution system from exhibiting charge-transfer interactions, 3807 electron-donating system by enzymic electric cell technique, 2947 Chelatingagent Simple synthesis of 4a-hydroperoxy adduct of 1,5-dihydroflavine: Model Covalent attachment of metal chelates to proteins: Stability in vivo and for bacterial luciferase, 995 in uitro of conjugate of albumin with chelate of Il"indium, 3803 Structural characterization of bridged 99Tc-Sn-dimethylglyoxime Chemicalenergy complex: Chemistry of 99mTc-radiopharmaceuticals prepared by Sn(II) Transduction of chemical into electrical energy, 82 reduction of pertechnetate, 4287 Chemicalrelaxation Structure of special-pair chlorophyll, 1791 Kinetic evidence for hapten-induced conformational transition in Subunit interfaces: Role in allosteric mechanism of hemoglobin, 3793 immunoglobulin MOPC 460, 3549 Ultraviolet photoelectron studies of biological purines: Valence electronic Chemicalsense structure of adenine, 2966 Anesthetic stimulation of insect water receptors, 3315 Uncoupling of local field spectra in nuclear magnetic resonance: Chemicalshift anisotropy Determination of atomic positions in solids, 1394 Nuclear magnetic resonance description of molecular motion and phase Viscosity of liquid metal, 988 separations of cholesterol in lecithin dispersions, 3812 Volume changes in binding of ligands to methemoglobin and Chemistry metmyoglobin, 4271 see also Cosmochemistry; Cytochemistry; Immunochemistry X-ray absorption edges in iron compounds and proteins, 1384 Amine-catalyzed hydrolyses of cyclodextrin cinnamates, 2969 Chemistry, analytical Angles between orthogonal spd bond orbitals with maximum strength, Electron probe x-ray analysis of single ferritin molecules, 1193 1403 Chemo-anemotaxis Assignment of locus required for flavoprotein-linked monooxygenase Chemo-anemotaxis: Behavioral response to sex pheromone in nonflying expression to human chromosome 2, 4266 insects, 2524 Blue copper centers in proteins, spectroscopic studies and structural Chemoeffector-receptor complex model, 1389 Receptor interactions in signalling system: Competition between ribose Carbon monoxide binding to pentacoordinate mercaptide-heme receptor and galactose receptor in chemotaxis response, 762 complexes: Kinetic study on models for cytochrome P-450, 3338 Chemotaxis Coherent anti-Stokes Raman scattering spectra, with resonance Acrasin of cellular slime mold Polysphondylium violaceum, 795 enhancement, of cytochrome c and vitamin B12 in dilute aqueous Change in membrane potential during bacterial chemotaxis, 4387 solution, 3329 Methylation of a membrane protein involved in bacterial chemotaxis Conformational properties of ribavirin, 4257 (correction), 977 Conformation of uncomplexed [Phe4,Val6]antamanide crystallized from mot gene product identified with Escherich;': ',?'- l,l.'.l( l .brid-., '126 nonpolar solvents, 1782 Receptor interactions in signalling system: ('o:ipt.lilioilIo blvewl< W ri:)o-t- Correlation of nonorthogonality of best hybrid bond orbitals with bond receptor and galactose receptor in chemotaxis response, 762 strength of orthogonal orbitals, 274 Role of peptidase in phagocyte chemotaxis, 2439 Covalent attachment of metal chelates to proteins: Stability in vivo and Chemotherapy in vitro of conjugate of albumin with chelate of mlindium, 3803 Solid tumor models for assessment of different treatment modalities: Covalently linked chlorophyll a dimer: Biomimetic model of special pair Systematics of response to radiotherapy and chemotherapy, 818 chlorophyll, 4282 Chicken Crystal structure of complex between lumiflavin and Abnormal response to minor histocompatibility antigens in Obese strain 2,6-diamino-9-ethylpurine: Flavin adenine dinucleotide model chickens, 2877 exhibiting charge-transfer interactions, 3807 RNA-dependent DNA polymerase, different from known viral reverse Dependence of interferon induction on nucleic acid conformation, 3788 transcriptases, in chicken system, 3025 2-Diazo-3,3,3-trifluoropropionyl chloride: Reagent for photoaffinity Chitin labeling, 1406 Chitin biosynthesis during Blastocladiella zoospore germination: Diffusion frequency factors in some simple examples of transition-state Hexosamine biosynthetic pathway is post-translationally activated rate theory, 679 during cell differentiation, 534 Double-stranded polynucleotides: Possible conformation, 2959 Structure and transformation of chitin synthase particles (chitosomes) Equation of state describing hydrophobic interactions, 2955 during microfibril synthesis in vitro, 4570 Ethidium bromide-(dC-dG-dC-dG)2 complex in solution: Intercalation Chitin synthase (EC 2.4.1.16) and sequence specificity of drug binding at tetranucleotide duplex Structure and transformation of chitin synthase particles (chitosomes) level, 3343 during microfibril synthesis in vitro, 4570 Favorskii-Nazarov reaction of dicyclopropyl ketone, 2945 Chitin synthetase Fluorescence-detected magnetic circular dichroism of fluorescent and see Chitin synthase nonfluorescent molecules, 276 Chitosome Fossil microorganisms from 2800 to 2500 million-year-old Bulawayan Structure and transformation of chitin synthase particles (chitosomes) stromatolite: Ultramicrochemical analyses, 2973 during microfibril synthesis in vitro, 4570 Free acid, anion, alkali, and alkaline earth complexes of lasalocid A Chlamydomonas reinhardi (X537A) in methanol: Structural and kinetic studies at monomer level, Putative sigma factor from Chlamydomonas reinhardi: Purification and 4277 characterization, 3961 Intramolecular energy transfer and molecular conformation, 271 Chloramphenicol Lasalocid A (X537A) and its silver, sodium, and barium salts: Structural Induction of delayed early RNA of bacteriophage T4 in vitro, 2569 and kinetic studies in nonpolar solvents, 1786 Chlorophyll Magnetic circular dichroism of ferrous carbonyl adducts of cytochromes Covalently linked chlorophyll a dimer: Biomimetic model of special pair P-450 and P-420 and their synthetic models: Mercaptide as fifth chlorophyll, 4282 ligand to iron, 6 Efficiency of energy transfer from photosystem II to photosystem I in Magnetic circular dichroism of molecules in dense media: Spin-forbidden Porphyridium cruentum, 3957 transitions of carbonyl molecules, 2964 "Energy upconversion" theory for green plant photosynthesis, 2773 Medium-induced radiationless transitions and effect of solvent on Path of electrons in photosynthesis, 4502 radiationless transitions, 2533 Structure of special-pair chlorophyll, 1791 Metal cluster in catalysis: Hydrocarbon reactions, 4274 Chloroplast Metalloprotein electron transfer reactions: Reactivity of horse heart Endonuclease recognition sites mapped on Zea mays chloroplast DNA, cytochrome c with inorganic complexes, 2950 4309 Metal-metal bond lengths in complexes of transition metals, 4290 "Energy upconversion" theory for green plant photosynthesis, 2773 Model membranes: Lateral hapten mobility and immunochemistry, 2977 Euglena chloroplast tRNAs: Transcriptional orilin, 1984 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4729

Large subunit ribulosebisphosphate carboxylase messenger RNA from Chromaffingranule Euglena chloroplasts, 722 Adenylatecyclase fromsecretory vesicle membranescontrolled by Photosynthetic unit in lettuce, 4560 f-adrenergicagents and nerve growthfactor, 771 Proton relaxation and charge accumulation during oxygen evolution in Chromaffinvesicle photosynthesis, 1196 Subcellulardistribution of protein carboxymethylaseand its endogenous Transitory tight binding of ATP and of committed Pi and ADP during substratesin adrenalmedulla: Role in excitation-secretioncoupling, ATP synthesis by chloroplasts, 4314 4050 Chloroplastcoupling factor 1 Chromatin Chloroplast coupling factor 1: Species-specific receptor for tentoxin, 2245 Acceptorproteins in rat androgenictissue chromatin,1954 Choleragen Activationof chromatinby acetylationof histone side chains, 3937 Choleragen-mediated release of trapped glucose from liposomes Chromatin:Solenoidal model for superstructure,1897 containing ganglioside GM1,3480 Dephosphorylationof nonhistoneproteins specifically alters patternof Cholera toxin interactions with thyrotropin receptors on thyroid plasma gene transcriptionin reconstitutedchromatin, 1174 membranes, 1679 Depositionof histone onto replicatingchromosome: Newly synthesized Effects of cholera toxin on cochlear endolymph production: Model for histone is not found near replicationfork, 2266 endolymphatic hydrops, 1761 DNA unwindingcomponent of nonhistonechromatin proteins, 4364 Functional incorporation of ganglioside into intact cells: Induction of Double-strandedRNA in chromatintranscripts formed by exogenous choleragen responsiveness, 1034 RNA polymerase,1121 Hydrolysis of nicotinamide adenine dinucleotide by choleragen and its A "Early"simian-virus-40-specific RNA containsinformation for tumor protomer: Role in activation of adenylate cyclase, 4424 antigen formationand chromatinreplication, 366 Relationship of gangliosides to structure and function of thyrotropin Fetal protein in chromatinof Novikoffhepatoma and Walker256 receptors: Their absence on plasma membranes of thyroid tumor carcinosarcomatumors that is absent from normaland regenerating defective in thyrotropin receptor activity, 4060 rat liver, 3258 Small fragments from A subunit of cholera toxin capable of activating Histones H3 and H4 interactwith the ends of nucleosomeDNA, 4400 adenylate cyclase, 2654 Messengerspecifying sequences in DNA of chromatinsubunits, 1572 Thyrotropin and cholera toxin used to probe mechanism by which Nonhistonechromatin proteins identified in chromatinsubunits, 3458 interferon initiates antiviral activity, 3695 Nuclease limit digestionpattern of chromatin,3391 Thyrotropin-ganglioside interactions and relationship to structure and Organizationof DNA in chromatin,3068 function of thyrotropin receptors, 842 Subnuclearsystems for synthesis of simian virus 40 DNA in vitro, 4392 Choleratoxin Subunit organizationin chickenerythrocyte chromatin, 505 see Choleragen Temporalrelationships of chromatinprotein synthesis, DNA synthesis, Cholesterol and assemblyof deoxyribonucleoprotein,2270 Adrenal cholesterol uptake from plasma lipoproteins: Regulation by Transcriptionin vitro of chromatinin presenceof mercurated corticotropin, 4329 nucleotide,1564 Analysis of membrane halves: Cholesterol, 173 Transcriptionin vitro of immunoglobulinkappa light chain genes in Binding, internalization, and degradation of low density lipoprotein by isolated mouse myelomanuclei and chromatin,775 normal human fibroblasts and by fibroblasts from homozygous familial Variabilityin DNA repeat length in chromatinof highereukaryotes, hypercholesterolemia, 14 4382 Cellular cholesterol ester accumulation induced by free cholesterol-rich Chromatography,affinity lipid dispersions, 3680 Affinitypurification of synthetic peptides,3160 Degradation of cationized low density lipoprotein and regulation of Alteredpenicillin-binding components in penicillin-resistantmutants of cholesterol metabolism in homozygous familial hypercholesterolemia Bacillus subtilis, 1816 fibroblasts, 3178 ATP-PPi exchangeactivity of progesteronereceptor, 3443 Genetic variation in serum low density lipoproteins and lipid levels in BacteriophageT5-induced endonucleases that introducesite-specific man, 937 single-chaininterruptions in duplex DNA, 1576 Low density lipoprotein receptors localized on plasma membrane of Calciumcontrol of actin-activatedmyosin adenosine triphosphatase from normal human fibroblasts and their absence in cells from familial Dictyosteliumdiscoideum, 2321 hypercholesterolemia homozygote, 2434 3':5'-CyclicGMP-dependent protein kinase: Purification and Nuclear magnetic resonance description of molecular motion and phase characterization,3918 separations of cholesterol in lecithin dispersions, 3812 Dietaryand hormonalregulation of content of acetyl coenzymeA Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity carboxylase-synthesizingpolysomes in rat liver, 2304 and cholesterol synthesis in nonhepatic tissues of rat, 2564 DNA unwindingcomponent of nonhistonechromatin proteins, 4364 Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Idiotypicantigen on monoclonalcold agglutininand on its isolated heavy hepatoma cells grown in vivo and in vitro, 2735 and light chains, 1702 Transbilayer distribution and movement of cholesterol and phospholipid Negative homotropiccooperativity and affinity heterogeneity: in membrane of influenza virus, 391 Preparationof yeast glyceraldehyde-3-phosphatedehydrogenase with Vertical displacement of membrane proteins mediated by changes in maximalaffinity homogeneity,3928 microviscosity, 4526 Restorationof oxidativephosphorylation by purified Choline N,N'-dicyclohexylcarbodiimide-sensitivelatent Choline synthesized from ethanolamine in rat brain, 2181 adenosinetriphosphatasefrom Mycobacteriumphlei, 3050 Nuclear magnetic resonance studies of interaction of general anesthetics Targetedattachment of peptides and proteinsto solid supports,3516 with 1,2-dihexadecyl-sn-glycero-3-phosphorylcholine bilayer, 3999 Chromatography,high-pressure liquid Cholinergic synapse Enzymaticconversion of benzo[a]pyreneleading predominantly to the Rat sympathetic neurons and cardiac myocytes developing in diol-epoxider-7t -8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo- microcultures: Correlation of fine structure of endings with [a]-pyrenethrough a single enantiomerof neurotransmitter function in single neurons, 4220 r-7,t-8-dihydroxy-7,8-dihydrobenzola]pyren&, 2594 Cholinesterase (EC 3.1.1.8) Hvdroc.nrhontrulcture in enzyme-catalyzedbenzo[a]pyrene-poly(G) Effects of persistent selective suppression of ganglionic ..i-E,iil(it-;:i:)ipi( . 1437 butyrylcholinesterase on steady state and regenerating levels of Metabolismof benzo[alpyrene:Conversion of acetylcholinesterase: Function of butyrylcholinesterase and regulation (?)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyreneto highly of protein synthesis, 2936 mutagenic7,8-diol-9,10-epoxides, 3381 Chondroblast Chromatography,oligo(dT)-cellulose Sulfated proteoglycans synthesized in nonchondrogenic cells, Mammalianmessenger RNA lackingpolyadenylate segment, 3088 presumptive chondroblasts, and chondroblasts, 3224 Partialpurification and characterizationof mRNA for rat preproinsulin, Chondrocyte 3539 Changes in type of collagen synthesized as clones of chick chondrocytes Unequalaccumulation of a- and f-globin mRNA in erythropoieticmouse grow and lose division capacity, 1674 spleen, 1811 Phenotypic transformation of clonal myogenic cells to cells resembling Chromatography,reversed phase column chondrocytes, 1989 Preparativefractionation of DNA restrictionfragments by reversed Chondrogenesis phase columnchromatography, 3117 Sulfated proteoglycans synthesized in nonchondrogenic cells, Chromosomalaberration presumptive chondroblasts, and chondroblasts, 3224 High blood pressurerelated to carcinogen-inducedunscheduled DNA Chondroitin ABC lyase (EC 4.2.2.4) synthesis,DNA carcinogenbinding, and chromosomalaberrations in Differential labeling of cell surface of single ciliary ganglion neurons in humanlymphocytes, 2496 vitro, 4100 Chromosome Sulfated proteoglycans synthesized in nonchondrogenic cells, see also Adenoviruschromosome; Protein, chromosomal presumptive chondroblasts, and chondroblasts, 3224 Chromosome,bacterial Choriogonadotropin F prime factors able to replicate in Escherichia coli Hfr strains, 198 Gonadotropin from nonpregnant subjects that has physical, Chromosome,Chinese hamster immunological, and biological similarities to human chorionic 5-Bromodeoxyuridine-DNA strand symmetry and repair of photolytic gonadotropin, 2885 breaks in Chinese hamster cell chromosomes, 3905 Isoimmunization against human chorionic gonadotropin with conjugates Chromosome, human of processed d-subunit of hormone and tetanus toxoid, 218 AKi:Np:ABO linkage group assigned to human chromosome 9, 895 Thyrotropin-ganglioside interactions and relationship to structure and Expression of human and suppression of mouse nucleolus organizer function of thyrotropin receptors, 842 activity in mouse-human somatic cell hybrids, 4531 Chorionicgonadotropin Genetics of somatic mammalian cells: Genetic, immunologic, and see Choriogonadotropin biochemical analysis with Chinese hamster cell hybrids containing selected human chromosomes, 193 Downloaded by guest on October 5, 2021 4730 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Human chromosome 3 releases block at Gi of cell cycle, in hybrids mot gene product identified with Escherichia coli-lambda hybrids, 3126 between tsAF8 hamster and human cells, 2052 Clostridium sticklandii Locus required for flavoprotein-linked monooxygenase expression Chemical characterization of selenoprotein component of clostridial assigned to human chromosome 2, 4628 glycine reductase: Selenocysteine is the organoselenium moiety, 2659 Chromosome, mouse Coagulation factor XI Chromosome-mediated gene transfer between closely related strains of Involvement of high molecular weight kininogen in surface-dependent cultured mouse cells, 2838 reactions of Hageman factor, 2554 Expression of human and suppression of mouse nucleolus organizer Coagulation factor XII activity in mouse-human somatic cell hybrids, 4531 Involvement of high molecular weight kininogen in surface-dependent Protein products of murine chromosome 17: Partial amino acid sequence reactions of Hageman factor, 2554 of H-2Kb molecule, 3661 Prekallikrein and high-molecular-weight kininogen: A complex in human Chromosome number plasma, 4179 Rates of evolution in seed plants: Net increase in diversity of Cobalt chromosome numbers and species numbers through time, 2086 Cobalt inhibition of synthesis and induction of 1-aminolevulinate Chromosome, polytene synthase in liver, 1499 Chromosomal proteins: Locations in polytene chromosomes, 2038 Metal-metal bond lengths in complexes of transition metals, 4290 Chromosome recombination Zn2+ as inhibitor and activator of fructose 1,6-bisphosphatase of rat Fusion of bacterial protoplasts, 2151 liver, 2692 Chromosome replication Cobalt enzyme Deposition of histone onto replicating chromosome: Newly synthesized Chemical reactivities of catalytic and noncatalytic zinc or cobalt atoms of histone is not found near replication fork, 2266 horse liver alcohol dehydrogenase: Differentiation by thermodynamic Chromosome, ring and kinetic properties, 344 Switches in polarity of chromosomal DNA, 877 Cobb-Douglas function Chromosome segregation Homogeneous functions and extended Cobb-Douglas forms, 3747 Loss of mouse chromosomes in somatic cell hybrids between HT-1080 Cobra venom human fibrosarcoma cells and mouse peritoneal macrophages, 3248 Prevention and iipnnreQ;q'nby azathioprine of venom-induced Chromosome, sex protein-losing .-..,-l?l')t, \:'. in dogs, 968 Abnormal ornithine carbamoyltransferase in mice having sparse-fur Cochlear potential mutation, 1693 Caecilian ear, 3744 Cell cycle analysis and X-chromosome inactivation in developing mouse, Ear and hearing in Sphenodon punctatus, 4244 1608 Cockroach dunce, a mutant of Drosophila deficient in learning, 1684 see Periplaneta americana Chromosome structure Coenzyme Chromosomal proteins: Locations in polytene chromosomes, 2038 Crystal structure of complex between lumiflavin and Determination of in situ distribution of chromosomal proteins, 423 2,6-diamino-9-ethylpurine: Flavin adenine dinucleotide model Linking numbers and , 2639 exhibiting charge-transfer interactions, 3807 Prokaryotic DNA visualized in a regularly condensed chromatin-like Coenzyme A fiber, 563 Klebsiella aerogenes citrate (pro-3S)-lyase: Structure of prosthetic Chromosome, wheat group, 1872 Gliadin protein components: Relationship to chromosomes in hexaploid Coenzyme Qlo wheats (Triticum aestivum L.), 3646 see Ubiquinone Chromosome, yeast Coherent anti-Stokes Raman scattering Chromosomal gene required for killer plasmid expression, mating, and Coherent anti-Stokes Raman scattering spectra, with resonance spore maturation in Saccharomyces cerevisiae, 2061 enhancement, of cytochrome c and vitamin B12 in dilute aqueous Chronometric cosmology solution, 3329 Chronometric cosmology, theoretical foundations, 669 Resonance enhanced coherent anti-Stokes Raman scattering, 3798 Chronometric principle Colchicine Interacting quantum fields and chronometric principle, 3355 Secretion of macrophage neutral proteinase enhanced by colchicine, 872 Chylomicron Tubulin aggregation and disaggregation: Mediation by two distinct Human blood plasma protein, rich in proline, with lipid-binding vinblastine-binding sites, 2375 properties, 1063 Colchicine-binding activity Chymotrypsin Antisera against electrophoretically purified tubulin stimulate ATP binding to protease-resistant core of actin, 2742 colchicine-binding activity, 1246 Carbohydrate moieties of procollagen: Incorporation of isotopically Coliphage labeled mannose and glucosamine into propeptides of procollagen see Bacteriophage secreted by matrix-free chick embryo tendon cells, 34 Collagen Homologous inhibitors from potato tubers of serine endopeptidases and see also Connective tissue; Procollagen metallocarboxypeptidases, 1941 Carbohydrate moieties of procollagen: Incorporation of isotopically Cibacron blue F3GA labeled mannose and glucosamine into propeptides of procollagen Cibacron blue F3GA binds to proteins containing dinucleotide fold, 361 secreted by matrix-free chick embryo tendon cells, 34 Cigarette Changes in type of collagen synthesized as clones of chick chondrocytes Hypersensitivity to tobacco antigen, 1712 grow and lose division capacity, 1674 Cilium Characterization of collagen synthesized by endothelial cells in culture, Cytoplasmic microtubules in tissue culture cells appear to grow from 2361 organizing structure towards plasma membrane, 867 Collagen fibrillogenesis: Intermediate aggregates and suprafibrillar order, Circadian rhythm 4027 Circadian organization of estrous cycle of golden hamster, 2923 D;pbervlhvdantnoin (Dilantin) gingival hyperplasia: Drug-induced Metabolic indicator of photoperiodic timing, 501 )i.i'... !',: i i?. "I , onnective tissue, 2909 Temperature dependence of cycloheximide-sensitive phase of circadian Dipnenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced cycle in Acetabularia mediterranea, 3216 abnormality of connective tissue (correction), 4247 Circular dichroism Fetal membrane collagens: Two new collagen alpha chains, 2579 Blue copper centers in proteins, spectroscopic studies and structural Simultaneous synthesis of types I and III collagen by fibroblasts in model, 1389 culture, 4037 Conformational changes in poly[d(A-T)-d(A-T)] in premelting region, Synthesis of type II collagen in vitro by embryonic chick neural retina 3453 tissue, 4420 Conformation of deazapurine nucleosides and of common purine Type I and type III collagens increased in human alcoholic liver nucleosides: Study by circular dichroism, 2384 cirrhosis, 539 Dependence of interferon induction on nucleic acid conformation, 3788 Vitamin A corta:ni-i. lipocytes and formation of type III collagen in Human pituitary growth hormone: Restoration of full biological activity liver injuly, j', 1J by noncovalent interaction of two fragments of hormone, 1476 Collagenase Solid phase synthesis of protein activator for lecithin-cholesterol Carbohydrate moieties of procollagen: Incorporation of isotopically acyltransferase corresponding to human plasma apoC-I, 1422 labeled mannose and glucosamine into propeptides of procollagen Somatostatin conformation: Stable intramolecular structure by circular secreted by matrix-free chick embryo tendon cells, 34 dichroism, diffusion, and sedimentation equilibrium, 1199 Collagenase (EC 3.4.24.3) Cirrhosis Collagenase and prostaglandins produced by isolated adherent Type I and type III collagens increased in human alcoholic liver rheumatoid synovial cells, 945 cirrhosis, 539 Secretion of macrophage neutral proteinase enhanced by colchicine, 872 Citrate (pro-3S)-lyase (EC 4.1.3.6) Colonization Klebsiella aerogenes citrate (pro-3S)-lyase: Structure of prosthetic Group selection among laboratory populations of Tribolium castaneum, group, 1872 4604 Clathrin Compensatory renal hypertrophy Clathrin: Protein associated with intracellular transfer of membrane by Cyclic nucleotide metabolism in compensatory renal hypertrophy and coated vesicles, 1255 neonatal kidney growth, 524 Clofibrate Competing risk Fatty acyl-CoA oxidizing system in rat liver peroxisomes: Enhancement Bounds for joint distribution function with fixed sub-distribution by clofibrate, a hypolipidemic drug, 2043 functions: Application to competing risks, 11 Cloning, molecular Competitive indeterminacy Method for cloning eukaryotic structural gene sequences, 3146 Competitive interdeterminacy in Tribolium, 1368 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4731

Complement Copperprotein see also Receptor, complement Blue copper centers in proteins, spectroscopic studies and structural Amplification convertase of complement is controlled by plasma protein model, 1389 1IH, 3268 Cordycepin Increased ion permeability of planar lipid bilayer membranes after Translational control in regulation of ferritin synthesis by iron, 857 treatment with C5b-9 cytolytic attack mechanism of complement, 2852 Corrections Molecular concept of properdin pathway, 612 Affinity of myosin S-1 for F-actin, measured by time-resolved Complementarity-determiningsegment fluorescence anisotropy, 2527 Correlations between specificity and sequence of first Antigen stimulation of prostaglandin synthesis and control of immune complementarity-determining segments of human kappa light chains, responses, 2527 4471 Assay of ribonuclease H, endoribonucleases, and phosphatases, 4711 Complementfixation Biological activity of catecholamines covalently linked to synthetic Model membranes: Lateral hapten mobility and immunochemistry, 2977 polymers: Immobilized drug theory, 2939 ComplexEuclidean space Control of oscillating glycolysis of yeast by stochastic periodic, and Structure of complete simply-connected Kahler manifolds with steady source of substrate: A model and experimental study, 661 nonpositive curvature, 1008 Conversion of Bacillus subtilis RNA polymerase activity in vitro by a Computer protein induced by phage SPOI, 661 Cytoarchitectonic mapping by microdensitometry, 2928 Determination of number of superhelical turns in simian virus 40 DNA Computersimulation by gel electrophoresis, 2527 Spike-forming model of neural membrane: Computer simulation of Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced additional perfused axon experiments, 100 abnormality of connective tissue, 4247 ConcanavalinA Escherichia coli dnaZ gene product involved in DNA elongation in vitro, see also Lectin; Receptor, concanavalin A 2939 Cell recognition in plants: Determinants of stigma surface and pollen Evoked neurotransmitter release: Statistical effects of nonuniformity and interactions, 2788 nonstationarity, 3320 Clustering and endocytosis of membrane, receptors can be induced in Free energy levels and entropy production in muscle contraction and in mature erythrocytes of neonatal but not adult humans, 4075 related solution systems, 2165 Concanavalin A affects expression of cell surface sialyltransferase Growth and differentiation in culture of leukemic leukocytes from a activity of mouse thymocytes, 837 patient with acute myelogenous leukemia and re-identification of Concanavalin-A-induced transmembrane linkage of concanavalin A type-C virus, 977 surface receptors to intracellular myosin-containing filaments, 4575 15-Hydroxyprostaglandin dehydrogenase specific for prostaglandin A in Effects of concanavalin A and succinylated derivative on lymphocyte rabbit kidney, 2528 proliferation and cyclic nucleotide levels, 1717 Immunogenicity: Immunon model of immune response, 4247 Human lymphocyte stimulation by concanavalin A: Role of valence and Initiation of in vitro mRNA synthesis from the wild-type lac , surface binding sites, 2118 1373 Magnetic resonance studies of concanavalin A: Binding site of Intramolecular crosslinking of tropomyosin via disulfide bond formation: cs-methyl-D-mannopyranoside, 322 Evidence for chain register, 2527 Monovalent derivatives of concanavalin A, 790 In vivo splicing of protein: One continuous polypeptide from two Surface membrane carbohydrate alterations of flagellated protozoan independently functioning operons, 661 mediated by bacterial endosymbiotes, 852 Mapping of in vivo messenger RNAs for bacteriophage 4X174, 4247 Virus and lectin agglutination of erythrocytes: Spin label study of Methylation of a membrane protein involved in bacterial chemotaxis, membrane lipid-protein interactions, 3497 977 Conformationalchange Morphine-like peptides in mammalian brain: Isolation, structure Isolated acetylcholine receptor protein: Kinetics of binding of elucidation, and interactions with opiate receptor, 4247 acetylcholine and Ca ions, 3994 Mucopolysaccharidoses (a review), 2165 Rate of quaternary structure change in hemoglobin measured by Preparation and microbial decomposition of synthetic [14C]lignins, 1373 modulated excitation, 4497 Primate type-C virus nucleic acid sequences (wooly monkey and baboon Conformationalenergy types) in tissues from patient with acute myelogenous leukemia and in Prediction of three-dimensional structures of enzyme-substrate and viruses isolated from cultured cells of same patient, 3320 enzyme-inhibitor complexes of lysozyme, 4261 Relativistic spherical vortex, 2527 Conformationalflexibility Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells, 4247 Conformational flexibility and protein folding: Rigid structural Transposition of R factor genes to bacteriophage X, 977 fragments connected by flexible joints in subtilisin BPN, 1974 Tropomyosin-binding component of rabbit skeletal muscle troponin: Conformationalmobility Amino-acid sequence, 4711 Charge pair model of bioenergetics: Redox enzymes, 2392 Correctiveendonuclease Conformationaltransition Detection of different types of damage in alkylated DNA by human Kinetic evidence for hapten-induced conformational transition in corrective endonuclease (correndonuclease), 2629 immunoglobulin MOPC 460, 3549 Corticosteroid-bindingglobulin Congressionalapportionment Photoaffinity site-specific covalent labeling of human House monotone apportionment schemes, 684 corticosteroid-binding globulin, 4462 Conjugatepoints Corticotropin Conjugate points on a limiting extremal, 1800 Adrenal cholesterol uptake from plasma lipoproteins: Regulation by Connectivetissue corticotropin, 4329 see also Collagen Cultured tumor cells: Affinity isolation by drugs and hormones Copper-induced activation of aortic lysyl oxidase in vivo, 371 covalently bound to glass and Sepharose beads, 2013 Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced Large product of cell-free translation of messenger RNA coding for abnormality of connective tissue, 2909 corticotropin, 4319 Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced Targeted attachment of peptides and proteins to solid supports, 3516 abnormality of connective tissue (correction), 4247 Cortisone Simultaneous synthesis of types I and III collagen by fibroblasts in Interferon treatment of mice: Enhanced expression of histocompatibility culture, 4037 antigens on lymphoid cells, 1284 Constantregion sequence Cosmochemistry Immunoglobulin allotypes of rabbit kappa chains: Polymorphism of Solar abundance of iridium, 269 control mechanism regulating closely linked duplicated genes? 1293 Solar abundance of osmium, 1382 Convergencealmost everywhere Cotton Maximal functions associated to smooth curves, 4295 see Gossypium barbadense Maximal functions: Homogeneous curves, 2176 Cotyledon Maximal functions: Spherical means, 2174 Reserve protein metabolism in cotyledons of mung bean seedlings, 3168 Vector-valued asymptotic martingales, 1798 Coumermycin Convexbody Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by Inverse problem for convex bodies, 1377 DNA gyrase, 4474 Cooperativeinteraction Couplingfactor Calcium binding in cerebral tissue: Sensitivity to weak environmental Transitory tight binding of ATP and of committed Pi and ADP during electric fields oscillating at low frequency, 1999 ATP synthesis by chloroplasts, 4314 Tetrahydrofolate: Cooperative interaction with pig kidney serine Courtship transhydroxymethylase and loss of cooperativity in L1210 tumors and Courtship in Drosophila mosaics: Sex-specific foci for sequential action in tissues of mice bearing these tumors, 1950 patterns, 4154 Cooperativity,negative homotropic Crayfishreceptor organ Negative homotropic cooperativity and affinity heterogeneity: Effects of deuterium oxide on mechano-sensory receptor, 4703 Preparation of yeast glyceraldehyde-3-phosphate dehydrogenase with Creutzfeldt-Jakob disease maximal affinity homogeneity, 3928 Serial propagation of Creutzfeldt-Jakob disease in guinea pigs, 223 Copperenzyme Crithidia oncopelti Copper-induced activation of aortic lysyl oxidase in vivo, 371 Surface membrane carbohydrate alterations of flagellated protozoan Coppermetabolism mediated by bacterial endosymbiotes, 852 Menkes disease: Biochemical abnormality in cultured human fibroblasts, Cross-bridgeproperties 604 Force-velocity characteristics for calcium-activated mammalian slow-tWitch and fast-twitch skeletal fibers from the guinea pig, 4693 Downloaded by guest on October 5, 2021 4732 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Crosslinking Induction and decay of glucagon-induced amino acid transport in Intrinsic transglutaminase in Ca2+-mediated crosslinking of erythrocyte primary cultures of adult rat liver cells: Paradoxical effects of proteins, 4479 cycloheximide and puromycin, 4511 Crossover connection Paradoxical effects of cycloheximide and cytochalasin B on hamster cell Handedness of crossover connections in 0 sheets, 2619 hexose uptake, 2429 Crossreacting material Temperature dependence of cycloheximide-sensitive phase of circadian Binding of.Triton X-100 to diphtheria toxin, crossreacting material 45, cycle in Acetabularia mediterranea, 3216 and their fragments, 4449 Cyclopropyl bond cleavage Crown gall teratoma of tobacco Favorskii-Nazarov reaction of dicyclopropyl ketone, 2945 Neoplastic state suppressed with acquisition of specialized functions in Cystamine cells, tissues, and organs of crown gall teratomas of tobacco, 496 Inhibition of erythrocyte sickling by cystamine, a thiol reagent, 3288 Recovery of crown gall tumor cells, 3562 Cysteine, seleno- Cryobiology. Chemical characterization of selenoprotein component of clostridial Survival of fetal rat pancreases frozen to -78 and -196?, 4105 glycine reductase: Selenocysteine is the organoselenium moiety, 2659 Crystallin Cystic fibrosis Absence of low-molecular-weight alpha crystallin in nuclear region of old Abnormal levels of 3':5'-cyclic AMP in isoproterenol-stimulated human lenses, 3484 fibroblasts from patients with cystic fibrosis, 2899 Quantitation of b-crystallin messenger RNA during lens induction in Cytoadsorption chick embryos, 2808 Detection and characterization of cell surface receptors for insulin by Crystal structure means of 125I-labeled autoantibodies against insulin receptor, 4115 Conductivity and structure of bilinear organic addition compounds, 3820 Cytoarchitectonic mapping Structural characterization of bridged 99Tc-Sn-dimethylglyoxime Cytoarchitectonic mapping by microdensitometry, 2928 complex: Chemistry of 99mTc-radiopharmaceuticals prepared by Sn(II) Cytochalasin B reduction of pertechnetate, 4287 Paradoxical effects of cycloheximide and cytochalasin B on hamster cell Uncoupling of local field spectra in nuclear magnetic resonance: hexose uptake, 2429 Determination of atomic positions in solids, 1394 Secretion of macrophage neutral proteinase enhanced by colchicine, 872 C-type virus Cytochemistry see also Antibody, C-type virus; Antigen, C-type virus Endoplasmic reticulum: A cytochemist's view (A Review), 2781 Antigen related to mammalian type-C RNA viral p30 proteins is located Cytochrome c in renal glomeruli in human systemic lupus erythematosus, 233 Coherent anti-Stokes Raman scattering spectra, with resonance Bvr-1, a restriction locus of a type-C RNA virus in feline cellular enhancement, of cytochrome c and vitamin B12 in dilute aqueous genome: Identification, location, and phenotypic characterization in solution, 3329 cat X mouse somatic cell hybrids, 4618 Fluorescence-detected magnetic circular dichroism of fluorescent and C-type virus particle formation in erythroblastic islands in spleens of nonfluorescent molecules, 276 C3Hf mice injected with erythropoietin, 3710 Interaction of integral and peripheral membrane proteins: Affinity Endogenous mouse type C virus activated by ultraviolet-irradiated labeling of yeast cytochrome oxidase by modified yeast cytochrome c, herpes simplex virus types I and 2, 646 4334 Growth and differentiation in culture of leukemic leukocytes from a Metalloprotein electron transfer reactions: Reactivity of horse heart patient with acute myelogenous leukemia and re-identification of cytochrome c with inorganic complexes, 2950 type-C virus (correction), 977 Nuclear magnetic resonance studies of slowly exchanging peptide Induction of mouse type-C virus by translational inhibitors: protons in cytochrome c in aqueous solution, 1398 Transcriptional derepression of specific class of endogenous virus, 4541 Primary structure of two cytochromes c2: Close similarity to functionally Murine type-C RNA virogenes suppressed by type-specific oncornavirus unrelated mitochondrial cytochrome c, 472 vaccines: Prospects for prevention of cancer, 620 Cytochrome c2. Natural antibodies in sera from healthy humans to antigens on surfaces Primary structure of two cytochromes c2: Close similarity to functionally of type C RNA viruses and cells from primates, 2491 unrelated mitochondrial cytochrome c, 472 Prevention of spontaneous leukemia in AKR mice by type-specific Cytochrome c, ferro- immunosuppression of endogenous ecotropic virogenes, 4633 Oxidation of ferrocytochrome c by mitochondrial cytochrome c oxidase, Primate type-C virus nucleic acid sequences (woolly monkey and baboon 113 types) in tissues from patient with acute myelogenous leukemia and in Cytochrome c3 hydrogenase (EC 1.12.2.1) viruses isolated from cultured cells of same patient, 2113 Separation of hydrogenase-catalyzed hydrogen-evolution system from Primate type-C virus nucleic acid sequences (wooly monkey and baboon electron-donating system by enzymic electric cell technique, 2947 types) in tissues from patient with acute myelogenous leukemia and in Cytochrome c oxidase (EC 1.9.3.1) viruses isolated from cultured cells of same patient (correction), 3320 Interaction of integral and peripheral membrane proteins: Affinity Radiation leukemia virus: Biological and serological characterization, labeling of yeast cytochrome oxidase by modified yeast cytochrome c, 4675 4334 Curvature decay Mitochondrial protein synthesis regulated by cytoplasmic proteins, 3947 Structure of complete simply-connected Kahler manifolds with Model for cytochrome oxidase, 2206 nonpositive curvature, 1008 Oxidation of ferrocytochrome c by mitochondrial cytochrome c oxidase, Cyanobacteria 113 Biliproteins of cyanobacteria and Rhodophyta: Homologous family of Cytochrome P-420 photosynthetic accessory pigments, 428 Magnetic circular dichroism of ferrous carbonyl adducts of cytochromes Cyanobacterial DNA-binding protein related to Escherichia coli HU, P-450 and P-420 and their synthetic models: Mercaptide as fifth 1917 ligand to iron, 6 Cyanocobalamin Cytochrome P-450 Coherent anti-Stokes Raman scattering spectra, with resonance Aryl 4-monooxygenase and cytochrome P-450 in aorta: Role in enhancement, of cytochrome c and vitamin B12 in dilute aqueous atherosclerosis, 3723 solution, 3329 Carbon monoxide binding to pentacoordinate mercaptide-heme Cyanogen bromide peptide complexes: Kinetic study on models for cytochrome P-450, 3338 Amino acid sequence at FdUMP binding site of thymidylate synthetase, Interactions between nutritional factors and drug biotransformations in 1848 man, 2501 Fetal membrane collagens: Two new collagen alpha chains, 2579 Magnetic circular dichroism of ferrous carbonyl adducts of cytochromes Cyclic AMP P-450 and P-420 and their synthetic models: Mercaptide as fifth see Adenosine 3':5'-cyclic monophosphate ligand to iron, 6 3':5'-Cyclic AMP phosphodiesterase Metabolic activation of aromatic hydrocarbons in purified rat liver see 3':5'-Cyclic-nucleotide phosphodiesterase nuclei: Induction of enzyme activities and binding to DNA with and Cyclic GMP without monooxygenase-catalyzed formation of active oxygen, 457 see Guanosine 3':5'-cyclic monophosphate Metabolism of benzo[a]pyrene: Conversion of Cyclic nucleotide metabolism (?)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly Calcium-dependent regulatory protein of cyclic nucleotide metabolism in mutagenic 7,8-diol-9,10-epoxides, 3381 normal and transformed chicken embryo fibroblasts, 2711 Cytochrome P-450 monooxygenase 3':5'-Cyclic-nucleotide phosphodiesterase (EC 3.1.4.17) Thermodynamic model of regulation: Modulation of redox equilibria in Calcium-dependent regulatory protein of cyclic nucleotide metabolism in camphor monoxygenase, 1078 normal and transformed chicken embryo fibroblasts, 2711 Cytochrome P-700 Conversion of 3T3 fibroblasts into adipose cells: Triggering of Structure of special-pair chlorophyll, 1791 differentiation by prostaglandin F2, and 1-methyl-3-isobutyl xanthine, Cytofluorometry 4516 Lymphocyte stimulation: Rapid multiparameter analysis, 2881 Regulation of dopamine stimulation of striatal adenylate cyclase by an Cytolysis, inhibition of endogenous Ca++-binding protein, 3887 Cell-mediated cytolysis of trinitrophenyl-derivatized target cells Sugars affect early biochemical events in development of Dictyostelium inhibited by alloantisera directed to products of K and D loci of the discoideum, 3183 H-2 complex, 625 Cyclodextrin cinnamate Cytoplasmic inheritance Amine-catalyzed hydrolyses of cyclodextrin cinnamates, 2969 Mitochondrial translation products in yeast: Location of determinants on Cycloheximide mitochondrial DNA, 1083 Biphasic stimulation of polyamine biosynthesis in primary mouse kidney Cytoplasmic streaming cells by infection with polyoma virus: Uncoupling from DNA and Polarity of actin filaments in Characean algae, 165 rRNA synthesis, 4022 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4733

Cytoplast Putative sigma factor from Chlamydomonas reinhardi: Purification and Nucleus-membraneinteraction in cappingof surfacemembrane characterization, 3961 receptors,4580 Deoxyribonucleic acid, chromatin subunit Cytosinedeamination Messenger specifying sequences in DNA of chromatin subunits, 1572 Heat mutagenesisin bacteriophageT4: Transitionpathway, 1269 Nuclease limit digestion pattern of chromatin, 3391 Variability in DNA repeat length in chromatin of higher eukaryotes, 4382 Dansylgalactoside Deoxyribonucleicacid, chromosomal Energy-dependentbinding of dansylgalactosideto lac carrierprotein: Switches in polarity of chromosomal DNA, 877 Direct bindingmeasurements, 109 Deoxyribonucleicacid, circular Dark adaptation Circular DNA of yeast episome with two inverted repeats: Structural Distributionof 3':5'-cyclicAMP and 3':5'-cyclicGMP in rabbitretina in analysis by restriction enzyme and electron microscopy, 3030 vivo:Effects of darkand light adaptationand ischemia,4442 Enzyme system for replication of duplex circular DNA: Replicative form Darwin'sfinches of phage ?X174, 1594 Darwin'sfinches: Population variation and naturalselection, 257 Superstructure of linear duplex DNA, 4125 Deacylation Deoxyribonucleicacid, cloningof Amine-catalyzedhydrolyses of cyclodextrincinnamates, 2969 Cloning of Escherichia coli DNA that controls cell division and capsular Deazapurinenucleoside polysaccharide synthesis, 697 Conformationof deazapurinenucleosides and of commonpurine Functional genetic expression of eukaryotic DNA in Escherichia coli, nucleosides:Study by circulardichroism, 2384 1471 Decayingstate, lifetime-widthrelation Molecular cloning of DNA fragments produced by restriction Lifetime-widthrelation for a decayingstate and the uncertainty endonucleases SalIl and BamI, 1537 principle,283 Molecular cloning of DNA from F sex factor of Escherichia coli K-12, 64 Decay kinetics Deoxyribonucleic acid, closed circular Short-livedmethylated messenger RNA in mouse kidney,2609 Restriction assay for integrative recombination of bacteriophage X DNA Decay law in vitro: Requirement for closed circular DNA substrate, 3524 Lifetime-widthrelation for a decayingstate and the uncertainty. Deoxyribonucleicacid, complementary principle,283 Anticomplementary nature of smaller DNA produced during synthesis of Deep inelasticscattering extensive DNA copies of poliovirus RNA, 3408 Deep inelastic scatteringof chargedleptons, 3816 Dephosphorylation of nonhistone proteins specifically alters pattern of Deep inelasticscattering of leptons, 3351 gene transcription in reconstituted chromatin, 1174 Defense mechanism DNA copies of poliovirus RNA synthesized in high yields and at high Ploy and counterployin predator-preyinteractions: Orb-weaving spiders specific activities, 2191 versusbombardier beetles, 1365 Method for cloning eukaryotic structural gene sequences, 3146 Deformation,moderately large mRNA sequences in nuclear 30S ribonucleoprotein subcomplexes, 2725 Soft polymers:Time-dependent response in moderatelylarge Sequences related to immunoglobulin kappa chain messenger RNA in T deformations,981 cells, 2467 Deletion mapping Stepwise biosynthesis in vitro of globin genes from globin mRNA by Modifiedrecombination and transmissionof mitochondrialgenetic DNA polymerase of avian myeloblastosis virus, 3418 markersin rho minus mutants of Saccharomycescerevisiae, 4608 Transcription in vitro of chromatin in presence of mercurated Denaturinggel nucleotide, 1564 Primarytranscripts in Ehrlichascites cells measuredby tetraphosphate Deoxyribonucleicacid crosslinking determination,1994 DNA single-strand breaks during repair of UV damage in human Dendriticspike fibroblasts and abnormalities of repair in xeroderma pigmentosum, 39 Tetrodotoxin-resistantdendritic spikes in avian Purkinjecells, 2520 Deoxyribonucleicacid damage Density gradientcentrifugation Deficiency of gamma-ray excision repair in skin fibroblasts from patients Ion distributionin subcellularmyocardial particulates separated by with Fanconi's anemia, 2419 density gradientcentrifugation with nonpolarliquid under ion Deoxyribonucleicacid double helix immobilizationconditions, 1754 Linking numbers and nucleosomes, 2639 Density labeling Deoxyribonucleicacid, double-strandbreaks Phytochrome-mediatedde novo synthesis of phenylalanine DNA strand breaks, repair, and survival in x-irradiated mammalian cells, ammonia-lyase:An approachusing pre-induced mustardseedlings, 809 4017 Segment of simian virus 40 genome containing origin of DNA replication: Density wave Isolation and propagation, 1513 Unstablespiral modes in disk-shapedgalaxies, 1379 Deoxyribonucleicacid, double-stranded Deoxycorticosterone,21-diazo-21- see also Polynucleotide, double-stranded Photoaffinitysite-specific covalent labeling of human Hybridization of RNA to double-stranded DNA: Formation of R-loops, corticosteroid-bindingglobulin, 4462 2294 Deoxyhemoglobin Kinetics of,branch migration in double-stranded DNA, 2299 see also Hemoglobin Deoxyribonucleicacid elongation Spectraldifferences between a and ,3 heme groupswithin human Escherichia coli dnaZ gene product involved in DNA elongation in vitro, deoxyhemoglobin,1140 1053 DeoxyhemoglobinS Escherichia coli dnaZ gene product involved in DNA elongation in vitro Polymerizationof deoxygenatedsickle cell hemoglobin:Thermodynamic (correction), 2939 studies, 990 Mechanism of DNA elongation catalyzed by Escherichia coli DNA DeoxyribonucleaseI (EC 3.1.4.5) polymerase III, dnaZ protein, and DNA elongation factors I and III, Covalentmodification of proteinsby metabolitesof NAD+, 3131 3511 Selective digestionof transcriptionallyactive ovalbumingenes from Deoxyribonucleic acid, episomal oviductnuclei, 3966 Characterization of 2-,m DNA of Saccharomyces cerevisiae by Deoxyribonucleicacid restriction fragment analysis and integration in an Escherichia coli L-Arabinoseoperon: Electron microscopy of gene regulation,1518 plasmid, 2072 Subunitorganization in chickenerythrocyte chromatin, 505 Deoxyribonucleicacid gyrase Deoxyribonucleicacid annealingkinetics DNA gyrase introduces superhelical turns into DNA, 3872 AKR-specificsequences increased in tumor tissues of leukemicAKR Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by mice, 2448 DNA gyrase, 4474 Germline integrationand Mendeliantransmission of exogenous Deoxyribonucleicacid heteroduplex Moloneyleukemia virus, 1260 Repair tracts in mismatched DNA heteroduplexes, 4135 Deoxyribonucleicacid, apurinic Deoxyribonucleicacid in chromatin Alteredapurinic DNA endonucleaseactivity in groupA and groupD Organization of DNA in chromatin, 3068 xerodermapigmentosum fibroblasts, 1169 Deoxyribonucleicacid, invertedrepeat sequence Deoxyribonucleicacid binding Electron microscopy of DNA crosslinked with trimethylpsoralen: Metabolicactivation of aromatichydrocarbons in purifiedrat liver Secondary structure of eukaryotic inverted repeat sequences, 2644 nuclei:Induction of enzymeactivities and bindingto DNA with and Deoxyribonucleicacid ligase without monooxygenase-catalyzedformation of active oxygen,457 see Polydeoxyribonucleotide synthetase (ATP) Deoxyribonucleicacid-binding protein Deoxyribonucleic acid, mammalian Cyanobacterial DNA-binding protein related to Escherichia coli HU, Intracellular precursor to DNA excreted by human lymphocytes, 3211 1917 Lymphocyte stimulation: Rapid multiparameter analysis, 2881 DNA-binding protein with characteristics expected for Cro protein of Deoxyribonucleicacid metabolism bacteriophage X, a repressor essential for lytic growth, 2249 Genetic controls of meiotic recombination and somatic DNA metabolism Deoxyribonucleic acid, bound to benzo[a]pyrene in Drosophila melanogaster, 4140 ( ? ) -7a,8(3-Dihydroxy-9(3,10,-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene is Deoxyribonucleicacid methylation an intermediate in metabolism and binding to DNA of benzo[a]pyrene, DNA methylation in adenovirus, adenovirus-transformed cells, and host 2679 cells, 3923 Deoxyribonucleicacid, chloroplast Deoxyribonucleicacid, mitochondrial Endonuclease recognition sites mapped on Zea mays chloroplast DNA, Mitochondrial translation products in yeast: Location of determinants on 4309 mitochondrial DNA, 1083 Growth conditions influence number of chloroplast DNA molecules in Structural heterogeneity of mitochondrial DNA molecules within the Euglena gracilis, 2401 genus Drosophila, 3623 Downloaded by guest on October 5, 2021 4734 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Deoxyribonucleic acid, molecular weight synvlthesis, IDNA carcinogen binlinig, and( chromnosomnal alberrations in Molecular weighlts determinie(d by fluctuation sp)ectroscopy: App)licati(on hIuman lymphocytes, 2496( to l)NA, 277(6 Recom(lbinatio( illn Saccharomyce's ('erul'si(ae: DNA repair rnut ation Structuiral hltcrogencity of nlitochondrial I)NA molecules within the associateil with elevate mitotiic gene coniversionI, 2828 gentis l)rosophiln, 3623 Repair tracts in mismatched IDNA heterotduplexes, 4135 Deoxyribonucleic acid, mouse Deoxyribonucleic acid, repetitive sequences Nucleotide sequences in mouise I)NA and RNA sl)ecific for Moloney \mpli!';c:1(;tn of mnllerate(ily repetitive I)DNA sequences (luring chick sarcomniavirus, 3705 ,.~~~~~:~'~.;, !,!.'.~;: ,:. 3428 Deoxyribonucleic acid nucleotidyltransferase Deoxyribonucleic acid replication Malpping oligonucleotides of Rous sarcomnaviruis RNA that segregate (Cell cycle analysis anmdX-chr(omosome inactivation in dtevel()ping moluse, withI plolymnerase and gro)up-sp)ecific antigen markers in recombinants, 1608 1952 (()nciatemers (f alternating plus ani minuls striands arte intermeidiates in Sinlultlaneolus initiation of synthesis of lbacterioplhage 'I4 I)NA and of adeni(ovirus-associatedi virus IDNA synithesis, 742 d(eoxyri)honucleotides, 757 IDNA fragment froim ()rigin ()f single-stranl t() double-strand IDNA Deoxyribonucleic acid nucleotidyltransferase (EC 2.7.7.7) retplicatin (f bacteri(ophage t fd, 419 lDecreased fidelity ('f 1)NA polyinerase activity isolated from aging n.zyme systemn for replicatio( ()f (duhplex circulair IDNA: lReplicative f(rm human fibroblasts, 2818 (f phage (XI 74,1,1.594 Esclhcri(clia (col dnaZ gene proiduct involved in I)NA elongation in vitro, Intermediate iso(late(t which preced(es dina(; RNA polymnerase 1115:1 lparticilpatio(I in eniz/ymatic repllicati(mi (f bacteriophage' (/X 174 1)NA. Esc?heric?hiacoli dnaZ gene product involved in D)NA elongation uiin tro 752 (correction), 2)939 Intterme(niate withI sinigle-stran(i break inllreacti(ln catalyze(t ly IDNA Eschcrichi'a co1 thi1redoxin: Sulunit olf bacteriophlage T7 D)NA untwisting en/iyme, 3488 polymerase, 780 Mechaniisinm (f IDNA elongatiom catalyzedl by Escherichia cloi I)NA Intracellular localization o(if motise I)NA polymerase-(, 1136 jpolymerase III, dnaZ proteiin, and IiDNA elonhmgationfactors I and III, Mechanism of I)NA elongation catalyzed bly Escherichia coli D)NA 3511 )o(lymerase III11,dnaZ protein. and I)NA elongation factors I and III, Nov()obiocin anid c(umiermycin inhibit I)NA superc()ilinig catalyze(l by 3511 DNA gyrase, 4474 Metal-induced infidelity during I)NA synthesis, 2331 Nuclear DINA repllicatioi in radicles (f germinating c(ottin, 3220 Nmucleotide sequences beyond sites of transcriptional termination, 717 Scgmient ()f simian virus .1(0genio-me c(intaininlig ()rigiln (f ID)NA repllication: Stepwise biosynthesis in 'itro oft glohbin genes frominglobin mRNA l)y Isolati(n a(ndp1ropagation, 1513:1 I)NA (polymerase' of avian nmyvelo)blastosis virus, 3418 Simian viruis 40 IDNA: In litlro repllication in nucle()lprotein complex, Variations of I)NA lpolymerases-a aind -(i during prolonged stimulation 3.166 of human lymihl(ocytes, 785 Structure ait 5'-en(Is (f nasceint I)NA chains, :13438 Deoxyribonucleic acid nucleotidyltransferase, ribonucleic acid-dependent Variations (f DNA polyreerases-i and( -fi (luring prolomge(d stimtulation Ant ic(miletmientary naturie (of smaller I)NA l)r(oducedi dutring synthesis (of (If human lympinilocytes, 785 extensive 1)NA ((copies (f t(li(ovirus RNA, 3,108 Deoxyribonucleic acid, replicative form I)NA'copies (f ()oli(ovirusIRNA synthesized in high yields and att high IDNA syn(thesis in tlitro (lepe(lndentt u1p(n1,1 X 17-1 repllicative f(rm I I)NA, specific activities, 2191 1887 RNA-dependent I)NA p(lymierase, different from known viral reverse l,nzymatic replicatin (If viral and co(mlplemeneitary strands (If dulplex tiranIscriptases. in chicken system1, 13025 I)NA (f plhage (/4X17i proc(ee(is by separate mi(chanismis, 3151 Simultane(ous detection (f reverse transcrilI)tase and high molecular Interm1 e(1iate is()late(t which pIreced(es dInaG ItNA p()lymerase weighlt RINA in tissue (otfpatients withl Hodgkin's disease and in human lparticipati(n in elnzymatic repllication (If bacteriophage (/ X 174 DINA, 1latients with leukemia, 4649 7(2 Synthesis of miurine leukemia viruis r(oteins associated with virions tRecombtination pr(om(IIteld by superhelical IDNA aind r(e(A gene (f assemibled in actilln(omycin I)D-treated cells: Persistence (of viral s'h crichlia coli, 3910 imessenger RNA, 1154 Replicatio( n (f mycoplasmavirus MVI 51: At tachmiient (f MVlI51 Ilpareital Deoxyribonucleic acid nucleotidyltransferase, ribonucleic acid dependent IDNA to h(ost celI memblrane, 14189 (EC 2.7.7.7) Deoxyribonucleic acid, ribosomal Circularization (f avian ((onco(rnavirus RNA genonme during plr(oviral I)NA l.calizatio( })y in sifn hylbri(tizatiin of amplified( rib()somal DNA (luring synthesis st(udied l)y reverse transcription iln nitro, 1329 X'cnopuls la,'l'is ocyte( maturation (light anti electro)n microsc()py Il'1heasantvirus: New class (of ribodeoxyvirus, 1333 stlludIy), 8133 Deoxyribonucleic acid of developing chick cartilage Deoxyribonucleic acid sequence 5-Blromtode(oxyuridincand thymidine distribution in I)NA of developing sete also Nucleotitle seqiiuence chick cartilage, (119 iochehmical mappiing (If eukaryotic viral IDNA by linikedi Deoxyribonucleic acid of t rans(1ril)tioIn-tranIslaition cell-free1- systemI, 2747 Ilistones 113 and H4 interact with the ends (of nucleosome I)NA, 4400 IDNA sequetnce organizaition in lepidi(I)pteran Anthueraca pe'rnvi, 2289 Deoxyribonucleic acid, postreplication repair Isolatiin (if inverted( repleat se(qutmces, incluiinig IS I, IS2, and IS3, in (Post replicati(on rep)air enhlanced in (ChIinese hamster cells, 2396 Esch'richia codl plasmids, 2:316 Deoxyribonucleic acid-protein complex Nucleot i(e seque:n-es beyoi(d sites ()f traiinscripti(mal termination, 717 Nicked I)NA lprotein co(nmplex froim simian virus 40: Covalent iPrep(arative fracti(nati(n (f I)NA restricrtiIn fragmenits by reverse(t attacl(ihmient of )rotein to INA and nick specificity, 1945 phase c(lumn chromat)graphy, 31 17 Deoxyribonucleic acid, proviral Restriction endomntclease isolate( frrom aci('mon)hihus p)araha(m.lvti(' Ctls, c''- 1 gene lr((oduct: ffeTct on lproviral I)NA f(ormiation and integration in 29:1 cells infected with murine leukemia viruses, 2236 Deoxyribonucleic acid, single-strand breaks Deoxyribonucleic acid reassociation Bacteri()phage T5-indwuce(t en(h)nucleases that intro)(uce site-specific Nucleic acid reassociation kinetics: Emplirical equations descrilbing I)NA single-chain interruptions in (duplex DNA, 1576 reassociation, 4154 I)NA single-strandi breaks (iluring repair ()f UV (taimage inll humana Selective digest(ion (of transcript i(onally active (ovalxilmin genes from fibr()oblasts 1and alnormalities (f repair in xerxliermia pigmentio)sulI, 319 oviduct nuclei, 3966 DNA strand breaks, repair, and survival in x-irradiate(d mammalian cells, Deoxyribonucleic acid, recombinant 809 see also ((enetic Ii r-ecolmlbinallti InterIle(Iliate with sinlgle-strand break in reactioin c(atalyzt.e(d I)v IDNA liochemicnial co(nstruction (f specific chimeric plasmids fromIiIColE I I)NA untwistinmg einymne, 3488 1andunnfractionated iIsclhcriclia ('oli I)NA, :13838 Nicked DNA protein cmnplex from simian virus 40: (ovalent ('(onstruct.ion and1)r(1)lagationO (f defective simianiii virus 40 genotime attachmint ()f protein to IDNA and niick specificity, 1945 be((aring (oleratolr fr(m1bacterio)lphage X, 10(68 Deoxyribonucleic acid, single-strand, circular (Constructioll (of plasmlids carrying the cl gene (of bacteriophage X, 4174 IPsoralen-cr)sslinke(Id sec(mi(iary structurte map (of single-stran(tded virius Exp)ression (f t lhymlidylatesynthetase gene (Iftacillus su btilis IDNA, 26.19 bacteriopliage Plhi :3-T in Escl('riclhil col, 4145 Replication ()f ()plasmavirus MVI,51: Attachment ()f MVI.51 parental Identification (f reco(mlbinants (f phage X, 3394 IDNA t.() host cell memibratne, 1,189 Methi((od f(r clo(ning eukaryotlic structural gene sequences, 3146i Deoxyribonucleic acid, single-stranded 11of gItreneproduct identified witih Ks(chl'richia col-lambda hybrids, 3126 IDNA Iunwinding c(impi(nent (If nlohistone chrmatin iproteins, 413641 Plasmid cl(oning vehicle allowing regulated expression (of eukaryotic I)NA Deoxyribonucleic acid structure in bacteria, .3900 seet also P(olynucleotide sect ndary strucltlure Specializted transdiucti(on (f colicin ElI )NA in Escherichia co( K-12 lby IDNA gyrase intro(duccs superhelical turnis inito IDNA, :1872 pliage lamnbda,3238 Ilouble-st randedpIt lynucleo(tides: I'Possible conf(ormatimi, 2959 Deoxyribonucleic acid repair Mechani sm(i f gentetic recmnbiination: Electron microsc()pic ()bsetrvati(n1 s11( als(o excision tep)air o,f recomlbinatio)nintermediates, ;30001 5-llroimnodeo(:(xyuridine-l)NA strand symmetry and repair of pholtolytic Nucl-har magne:tic resonance studies (If helix colil transiti(on (If breaks in (Chines hamster cell chfrolmoIsomnues,3905 po)ly(dtA-d!rT)in aqtueo)ussol[ution, 674 IIefective ihyminh dimer excision by cell-free extracts of xeroderma mIrokarvo1ticIDNA visualiized in a regularly co(nhensedI chrolmatin-like p)i.,.men)to)iinicel:ls, 2757 fi11r, 56.3 ID(.lIt(' (llo I ilIt ereni lypes oIf damage in alkylated I)NA by human Superstructure (of linear dtup)lex I)NA, -1i25 coIrrIective endonucl ease (c(orrenionuiclease), 2629 Deoxyribonucleic acid synthesis t"ndoIlnu(lehase: II, aptarin'i acill endi(nuclease, and exoluc.llease III, 4324 Activity (of yeast extracts in cell-free stimIulation o(f I)NA repili'atlion, (;(inet-it' (co1ntro(lso1 meif(ticf recombinatio n and solmatic I)NA metabolism in )'ro.sophi( m'hlnogastfr, 411,-I) Amino) acids and controil (f nuc:le(lar size, the activity (If ItNA 11gigh fbloohd p1r1essurereirated ti carcin(ogen-inducetl unscht'tduled D)NA po{)lymeras(e [, and 1DNA synthesis in liver, :3201 I, iphasil stimulation ofpolyamineI(If }bio)synthesis in primary not)use-kidney Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4735

cells by infection with polyoma virus: Uncoupling from DNA and Deoxyuridine,5-bromo- rRNA synthesis, 4022 Amplification of, moderately repetitive DNA sequences during chick Circularization of avian oncornavirus RNA genome ddiring proviral DNA cartilage differentiation, 3428 synthesis studied by reverse transcription in vitro, 1329 5-Bromodeoxyuridine and thymidine distribution in DNA of developing Concatemers of alternating plus and minus strands are intermediates in chick cartilage, 1019 adenovirus-dssociated virus DNA synthesis, 742 5-Bromodeoxyuridine-DNA strand symmetry and repair of photolytic Control of growth of benzo[a]pyrene-transformed 3T3 cells, 3229 breaks in Chinese hamster cell chromosomes, 3905 Deposition of histone onto replicating chromosome: Newly synthesized Deoxyuridine, 5-fluoro- histone is not found near replication fork, 2266 Biphasic stimulation of polyamine biosynthesis in primary mouse kidney Different calcium requirements for proliferation of conditionally and cells by infection with polyoma virus: Uncoupling from DNA and unconditionally tumorigenic mouse cells, 1.651 rRNA. synthesis, 4022 Differential effect of phosphonoacetic acid on.expression of Deoxyuridine,5-iodo- Epstein-Barr viral antigens and virus production, 1745 Differential effect of phosphonoacetic acid on expression of Epstein-Barr DNA synthesis in vitro dependent upon 4X174 replicative form I DNA, viral antigens and virus production, 1745 1887 de Sanctis-Cacchionesyndrome "Early" simian-virus-40-specific RNA contains information for tumor Altered apurinic DNA endonuclease activity in group A and group D antigen formation and chromatin replication, 366 xeroderma pigmentosum fibroblasts, 1169 Escherichia coli thioredoxin: Subunit of bacteriophage T7 DNA Detergent polymerase, 780 see also Triton X-100 F prime factors able to replicate in Escherichia coli Hfr strains, 198 Detergentbinding Hormonal stimulation of DNA synthesis in primary cultures of adult rat Molecular weight of protein moiety in protein-detergent complexes hepatocytes, 3589 determined without direct knowledge of detergent binding, 4467 Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate Deuterium oxide reductase dependent upon glutathione, 2275 Effects of deuterium oxide on mechano-sensory receptor, 4703 Inhibitor of DNA synthesis isolated specific for normal and malignant Developmentalbiology mammary cells, 2196 RNase sensitivity of anterior morphogenetic determinant in insect egg Initiation of replication in chromosomal DNA induced by extracts from (Smittia sp., Chironomidae, Diptera), 3739 proliferating cells, 2231 Development,human Metal-induced infidelity during DNA synthesis, 2331 Bandage-backfall reaction: Occurs in infancy, hypothalamic damage, and (-Methylornithine, potent competitive inhibitor of ornithine catalepsy, 3311 decarboxylase, blocks proliferation of rat hepatoma cells in culture, Dexamethasone 1626 Induction and decay of glucagon-induced amino acid transport in Origin and direction of synthesis of bacteriophage fl DNA, 2341 primary cultures of adult rat liver cells: Paradoxical effects of Polypeptide of 18,000 molecular weight induces early events and cycloheximide and puromycin, 4511 stimulates DNA synthesis in cultured cells, 4555 Dextran,soluble Simultaneous initiation of synthesis of bacteriophage T4 DNA and of Soluble dextran-hemoglobin complex: Potential blood substitute, 2128 deoxyribonucleotides, 757' Dextrin dextranase (EC 2.4.1.2) Subnuclear systems for synthesis of simian virus 40 DNA in vitro, 4392 Transcription-translation and translation-messenger RNA decay Synthesis of nuclear proteins during DNA repair synthesis in human coupling: Separate mechanisms for different messengers, 1126 diploid fibroblasts damaged with ultraviolet radiation or Diabetes N-acetoxy-2-acetylaminofluorene, 1466 see also Alloxan-diabetes; Diabetes mellitus; Diabetogenic peptide Temporal relationships of chromatin protein synthesis, DNA synthesis, Detection and characterization of cell surface receptors for insulin by and assembly of deoxyribonucleoprotein, 2270 means of 125I-labeled autoantibodies against insulin receptor, 4115 Xenopus laevis oocyte extract affects supercoiled simian virus 40 DNA: Hvnertr,,phy and hyperplasia of somatostatin-containing D-cells in Formation of complex DNA, 554 Deoxyribonucleic acid, synthetic Survival of fetal rat pancreases frozen to -78 and -196?, 4105 Conformational changes in poly[d(A-T)-d(A-T)] in premelting region, Diabetes mellitus 3453 Glycosylation of hemoglobin in vitro: Affinity labeling of hemoglobin by Deoxyribonucleic acid untwisting enzyme glucose-6-phosphate, 3534 Intermediate with single-strand break in reaction catalyzed by DNA Diabetogenicpeptide untwisting enzyme, 3488 Diabetogenic peptide from human growth hormone: Partial purification Deoxyribonucleic acid unwinding protein from peptic digest and long-term action in ob/ob mice, 4706 Intermediate isolated which precedes dnaG RNA polymerase Diadenosine 5',5"'-P1,P4-tetraphosphate participation in enzymatic replication of bacteriophage 4X174 DNA, Diadenosine 5',5`'-P1,P4-tetraphosphate (Ap4A) in mammalian cells in 752 levels varying widely with proliferative activity of tissue: Possible Deoxyribonucleic acid, viral positive "pleiotypic activator", 3984 Bacteriophage T4 gene whose product prevents true late transcription on Dianion intermediate cytosine-containing T4 DNA, 3098 Favorskii-Nazarov reaction of dicyclopropyl ketone, 2945 Biochemical mapping of eukaryotic viral DNA by linked Diaptomus nevadensis transcription-translation cell-free system, 2747 Photoprotection by carotenoid pigments in copepod Diaptomus BK virus DNA occurs in DNA obtained from certain human tumors, nevadensis, 971 4662 2-Diazo-3,3,3-trifluoropropionylchloride Chromatin-like organization of adenovirus chromosome, 401 2-Diazo-3,3,3-trifluoropropionyl chloride: Reagent for photoaffinity Determination of number of superhelical turns in simian virus 40 DNA - labeling, 1406 by gel electrophoresis (correction), 2527 Dichloromethane DNA fragment from originrof single-strand to double-strand DNA . Dichloromethane as antisickling agent in sickle cell hemoglobin, 4195 replication of bacteriophage fd, 49 Dictyostelium discoideum DNA-relaxing activity and endonuclease activity in Xenopus laevis Calcium control of actin-activated myosin adenosine triphosphatase from oocytes, 4551 Dictyostelium discoideum, 2321 Do highly oncogenic group A human adenoviruses cause human cancer? Differentiation stimulating factor induces cell sensitivity to 3':5'-cyclic Analysis of human tumors for adenovirus 12 transforming DNA AMP pulses in Dictyostelium discoideum, 1250 sequences, 4657 Sugars affect early biochemical events in development of Dictyostelium Escherichia coli dnaZ gene product involved in DNA elongation in vitro, discoideum, 3183 1053 Dicyclohexylcarbodiimide,N,N'- Escherichia coli dnaZ gene product involved in DNA elongation in vitro Restoration of oxidative phosphorylation by purified (correction), 2939 N,N'-dicyclohexylcarbodiimide-sensitive latent Genetic recombination of bacteriophage T7 DNA in vitro, 692 adenosinetriphosphatase from Mycobacterium phlei, 3050 Host restriction of Friend leukemia virus: Synthesis and integration of Dicyclopropyl ketone provirus, 2356 Favorskii-Nazarov reaction of dicyclopropyl ketone, 2945 Human papilloma virus DNA: Physical mapping and genetic Diet heterogeneity, 1310 see also Nutrition Integrated simian virus 40 sequences in transformed cell DNA: Analysis Dietary and hormonal regulation of content of acetyl coenzyme A using restriction endonucleases, 1102 carboxylase-synthesizing polysomes in rat liver, 2304 Intracellular forms of adenovirus DNA: Integrated form of adenovirus Diet: Influence on survival of mice, 1279 DNA appears early in productive infection, 1043 Interactions between nutritional factors and drug biotransformations in Isolation and characterization of protein coded by gene A of man, 2501 bacteriophage $X174 DNA, 2669 Differential scanning calorimetry Localization of gene functions in polyoma virus DNA, 4169 Subcellular localization of S-adenosyl-L-methionine:tRNA Mismatched base-pair regions in polyoma heteroduplex DNA: Fate methyltransferases with aminoacyl-tRNA synthetases in human and during infection of mouse cells, 3073 mouse: Normal and leukemic leukocytes, 3862 Replication ofmycoplasmavirus MVL51: Attachment of MVL51 parental Differentiation, antibody DNA to host cell membrane, 1489 Antibody differentiation: Apparent sequence identity between variable Simian virus 40 DNA: In vitro replication in nucleoprotein complex, regions shared by IgA and IgG immunoglobulins, 923 3466 Differentiation, cell Single-stranded complementary ends appear in viuo on parental Amplification of moderately repetitive DNA sequences during chick herpesvirus DNA, 2674 cartilage differentiation, 3428 Deoxyribonucleoprotein Aplastic anemia: Presence in human bone marrow of cells that suppress Temporal relationships of chromatin protein synthesis, DNA synthesis, myelopoiesis, 2890 and assembly of deoxyribonucleoprotein, 2270 5-Bromodeoxyuridine and thymidine distribution in DNA of developing chick cartilage, 1019 Downloaded by guest on October 5, 2021 4736 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Chitin biosynthesis during Blastocladiella zoospore germination: -dependent GTPase from yeast distinct from elongation factor Hexosamine biosynthetic pathway is post-translationally activated 2, 73 during cell differentiation, 534 Dipole moment Clonal variation in albumin messenger RNA activity in hepatoma cells, Retinal has highly dipolar vertically excited singlet state: Implications 2056 for vision, 2169 Control of development: Role of regulatory nucleotides synthesized by Diprenorphine membranes of Bacillus subtilis in initiation of sporulation, 331 Opiate receptor: Autoradiographic localization in rat brain, 3729 Conversion of 3T3 fibroblasts into adipose cells: Triggering of Discrete Fourier Transform differentiation by prostaglandin F2,, and 1-methyl-3-isobutyl xanthine, Computing the Discrete Fourier Transform, 1005 4516 Discrete groups Differentiation stimulating factor induces cell sensitivity to 3':5'-cyclic High dimensional cohomology of discrete groups, 1795 AMP pulses in Dictyostelium discoideum, 1250 Diseases of human beings Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in See end of this listing for diseases about which there are more than one tissue cultures of rat erythroleukemia cells transformed by paper; see also Genetic disease; Metabolic disease; specific diseases 7,12-dimethxylbenz(a)anthracene. 1237 Abnormal levels of 3':5'-cyclic AMP in isoproterenol-stimulated Erythroid (ell (iilcrl-llatr llio: M.tirine erythroleukemia cell variant with fibroblasts from patients with cystic fibrosis, 2899. unique pattern of induction by polar compounds, 1232 Alterations in cell surface glycosphingolipids and other lipid classes of ^y-Glutamyltranspeptidase, a lymphoid cell-surface marker: Relationship fibroblasts in familial hypercholesterolemia, 4339 to blastogenesis, differentiation, and neoplasia, 2414 Androgen insensitivity in man: Genetic heterogeneity, 891 Growth of transplanted tails of infant rats in adolescent allogeneic Antigen related to mammalian type-C RNA viral p30 proteins is located recipients, 3283 in renal glomeruli in human systemic lupus erythematosus, 233 Noradrenergic clonal line of rat adrenal pheochromocytoma cells Aplastic anemia: Presence in human bone marrow of cells that suppress established which respond to nerve growth factor, 2424 myelopoiesis, 2890 Ontogeny of mouse B lymphocytes and inactivation by antigen of early B Collagenase and prostaglandins produced by isolated adherent 'v-nh.l.octoe. 2462 rheumatoid synovial cells, 945 :,.;.I~ -,,l 'i:urine B lymphocytes: Sequence of B-cell differentiation Elevated angiotensin converting enzyme in lymph nodes containing from surface-immunoglobulin-negative precursors to plasma cells, 2008 non-necrotizing granulomas in sarcoidosis, 2137 Photoreceptor pigment that induces differentiation in slime mold Enveloped virus acquires membrane defect when passaged in fibroblasts Physarum polycephalum, 3896 from I-cell disease patients, 2443 Potent inducers of differentiation in murine erythroleukemia cells, 862 Enzyme replacement therapy in Gaucher's disease: Purification of Quantitation of 5-crystallin messenger RNA during lens induction in glucocerebrosidase, 4672 chick embryos, 2808 Genetic variation in serum low density lipoproteins and lipid levels in Sulfated proteoglycans synthesized in nonchondrogenic cells, man, 937 presumptive chondroblasts, and chondroblasts, 3224 Hepatitis B vaccine trial, study design, 955 Totipotency and normal differentiation of single teratocarcinoma cells High blood pressure related to carcinogen-induced unscheduled DNA cloned by injection into blastocysts, 549 synthesis, DNA carcinogen binding, and chromosomal aberrations in Differentiation, electrical human lymphocytes, 2496 Maturation of neuroblastoma cells in presence of dimethylsulfoxide, 462 Human myasthenia gravis: Electrophysiological and ultrastructural Differentiation, sexual evidence compatible with antibody attachment to acetylcholine Circadian organization of estrous cycle of golden hamster, 2923 receptor complex, 4584 Obligatory role of hypophysis in sexual differentiation of hepatic Human papilloma virus DNA: Physical mapping and genetic metabolism in rats, 1462 heterogeneity, 1310 Tissue interaction in androgen response of embryonic mammary Hypersensitivity to tobacco antigen, 1712 rudiment of mouse: Identification of target tissue for testosterone, Hypertrophy and hyperplasia of somatostatin-containing D-cells in 4041 diabetes, 1338 Diffusion Immunoglobulin variant: y3 heavy chain disease protein CHI, 1552 Somatostatin conformation: Stable intramolecular structure by circular Measles virus-specific IgD antibodies in patients with subacute dichroism, diffusion, and sedimentation equilibrium, 1199 sclerosing panencephalitis, 1297 Diffusion frequency factor Menkes disease: Biochemical abnormality in cultured human fibroblasts, Diffusion frequency factors in some simple examples of transition-state 604 rate theory, 679 Molecular abnormality of human alphal-antitrypsin variant (Pi-ZZ) (-)Dihydroalprenolol associated with plasma activity deficiency, 1324 Desensitization of 3-adrenergic receptors by (-adrenergic agonists in Mouse amyloid protein AA: Homology with nonimmunoglobulin protein cell-free system: Resensitization by guanosine of human and monkey amyloid substance, 964 5'-((3,-y-imino)triphosphate and other purine nucleotides, 1494 Porphyria variegata and porphyria cutanea tarda in siblings: Chemical 1,5-Dihydroflavine, 4a-hydroperoxy adduct of and genetic aspects (Addendum), 1323 , Simple synthesis of 4a-hydroperoxy adduct of 1,5-dihydroflavine: Model Serial propagation of Creutzfeldt-Jakob disease in guinea pigs, 223 for bacterial luciferase, 995 Type I and type III collagens increased in human alcoholic liver Dihydrotestosterone cirrhosis, 539 see also Receptor, dihydrotestosterone Diseases of human beings (cancer) Acceptor proteins in rat androgenic tissue chromatin, 1954 Cancer-associated isoenzyme of serum galactosyltransferase, 1319 Dimethylglyoxime Cell surface antigens of human malignant melanoma: Mixed Structural characterization of bridged 99Tc-Sn-dimethylglyoxime hemadsorption assays for humoral immunity to cultured autologous complex: Chemistry of 99mTc-radiopharmaceuticals prepared by Sn(II) melanoma cells, 3278 reduction of pertechnetate, 4287 Do highly oncogenic group A human adenoviruses cause human cancer? Dimethyl suberimidate Analysis of human tumors for adenovirus 12 transforming DNA Functional repressor parts of tetrameric -(-galactosidase sequences, 4657 chimera are organized as dimers, 3529 Electrophoretic distributions of human peripheral blood mononuclear Q( RNA replicase reconstituted from covalently bonded elongation white cells from normal subjects and from patients with acute factor Tu-Ts complex, 1131 lymphocytic leukemia, 2388 Dimethylsulfoxide Elevated serum ribonuclease in patients with pancreatic cancer, 2308 Brain tubulin polymerization in absence of microtubule associated Growth and differentiation in culture of leukemic leukocytes from a proteins, 4397 patient with acute myelogenous leukemia and re-identification of DI;-..'.- il..-ii,.x;lt- 'imi: t ' differentiation and hemoglobin synthesis in type-C virus (correction), 977 :' '-..l- .l.I 'I\ I: hroleukemia cells transformed by Isolation from patients with breast cancer of antibodies specific for 7,12-dimethylbenz(a)anthracene, 1237 antigens associated with breast cancer and other malignant diseases, Erythroid cell differentiation: Murine erythroleukemia cell variant with 2101 unique pattern of induction by polar compounds, 1232 Rheumatoid factor and tumor-host interaction, 2106 Maturation of neuroblastoma cells in presence of dimethylsulfoxide, 462 Simultaneous detection of reverse transcriptase and high molecular 2,4-Dinitrophenyl-cadaverine weight RNA in tissue of patients with Hodgkin's disease and in human Elimination of rotating carrier mechanism for active transport of Ca ion patients with leukemia, 4649 in sarcoplasmic reticulum membranes, 1532 Supplemental ascorbate in supportive treatment of cancer: Prolongation Dinucleotide fold of survival times in terminal human cancer, 3685 Cibacron blue F3GA binds to proteins containing dinucleotide fold, 361 Surface marker characteristics and Epstein-Barr virus studies of two Diphenylhydantoin established North American Burkitt's lymphoma cell lines, 228 Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced Diseases of human beings (Fanconi's anemia) abnormality of connective tissue, 2909 Deficieni-y of gammia ray excision repair in skin fibroblasts from patients Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced with ;-ailm'l.is ai,emlia. 2419 abnormality of connective tissue (correction), 4247 Hemoglobin Wayne: Frameshift mutation detected in human 2,3-Diphosphoglycerate hemoglobin alpha chains, 882 Sherpas living permanently at high altitude: Pattern of adaptation, 747 Diseases of human beings (homozygous familial hypercholesterolemia) Diphtheria toxin Binding, internalization, and degradation of low density lipoprotein by Amino-acid sequence of Fragment A, enzymically active fragment from normal human fibroblasts and by fibroblasts from homozygous familial diphtheria toxin, 69 hypercholesterolemia, 14 Binding of Triton X-100 to diphtheria toxin, crossreacting material 45, Degradation of cationized low density lipoprotein and regulation of and their fragments, 4449 cholesterol metabolism in homozygous familial hypercholesterolemia Cultured tumor cells: Affinity isolation by drugs and hormones fibroblasts, 3178 covalently bound to glass and Sepharose beads, 2013 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4737

Low density lipoprotein receptors localized on plasma membrane of Ecology normal human fibroblasts and their absence in cells from familial see also Environment hypercholesterolemia homozygote, 2434 Calculationof immigrationand extinctioncurves from Diseases of humanbeings (mucopolysaccharidosis) species-area-distancerelation, 4130 MucoDolvsaccharidoses (A Review), 630 Darwin'sfinches: Population variation and naturalselection, 257 Mucopolysaccharidoses (A Review) (correction), 2165 Evolution,population dynamics, and stability, 665 Diseases of humanbeings (severecombined immunodeficiency) Species-arearelation for birds of SolomonArchipelago, 262 Normal level of adenosine deaminase activity in red cell lysates of Economicsciences carriers and patients with severe combined immunodeficiency disease, Homogeneousfunctions and extended Cobb-Douglasforms, 3747 104 Eel electroplaques Residual enzyme activity in fibroblasts from patients with adenosine Temperaturedependence of four ionic processesof spike electrogenesis deaminase deficiency and combined immunodeficiency: Evidence for in eel electroplaques,3554 mutant enzyme, 213 Eel esophagus Diseases of humanbeings (sickle cell disease) Eel esophagusas osmoregulatoryorgan, 1348 Dichloromethane as antisickling agent in sickle cell hemoglobin, 4195 Egg endoplasm Supersaturation in sickle cell hemoglobin solutions, 3035 Maturation(meiosis) in small Xenopus laevis oocytes inducedby Diseases of humanbeings (xerodermapigmentosum) injectionof maturationpromoting factor, 2028 Altered apurinic DNA endonuclease activity in group A and group D Eggplantmosaic virus xeroderma pigmentosum fibroblasts, 1169 Structureof amino-acidaccepting 3'-end of high-molecular-weight Defective thymine dimer excision by cell-free extracts of xeroderma eggplantmosaic virus RNA, 737 pigmentosum cells, 2757 Egg zona pellucida Dissipativesystem Immunologicalblock to mammalianfertilization: Survival and organ Kinetic theory and ergodic properties, 1802 distributionof immunoglobulinwhich inhibits fertilizationin vivo, Disulfidebond 2405 Segment-long-spacing aggregates and isolation of COOH-terminal Ehrlichascites cell peptides from type I procollagen, 4304 Interferon,double-stranded RNA, and proteinphosphorylation, 3107 Disulfidebond formation Primarytranscripts in Ehrlichascites cells measuredby tetraphosphate Intramolecular crosslinking of tropomyosin via disulfide bond formation: determination,1994 Evidence for chain register (correction), 2527 Elastase (EC 3.4.21.11) Diureticagent Secretionof macrophageneutral proteinase enhanced by colchicine,872 15-Hydroxyprostaglandin dehydrogenase specific for prostaglandin A in Elastomer rabbit kidney, 1107 Soft polymers:Time-dependent response in moderatelylarge Dopamine deformations,981 Dopamine receptors in human and calf brains, using [3H]apomorphine Electricalcapacity and an antipsychotic drug, 4354 Analoguesolution for electricalcapacity of membrane-coveredcubes in Regulation of dopamine stimulation of striatal adenylate cyclase by an cubic arrayat high concentration,4003 endogenous Ca++-binding protein, 3887 Electricalenergy Drosophila Transductionof chemicalinto electricalenergy, 82 Courtship in Drosophila mosaics: Sex-specific foci for sequential action Electricfield effect patterns, 4154 Retinal has highly dipolarvertically excited singlet state: Implications Structural heterogeneity of mitochondrial DNA molecules within the for vision, 2169 genus Drosophila, 3623 Electricfield, weak en'fironmental Drosophilamelanogaster Calciumbinding in cerebraltissue: Sensitivity to weak environmental Determination of in situ distribution of chromosomal proteins, 423 electric fields oscillatingat low frequency,1999 dunce, a mutant of Drosophila deficient in learning, 1684 Electrochemicalgradient of protons Genetic controls of meiotic recombination and somatic DNA metabolism Electrochemicalgradient of protonsand its relationshipto active in Drosophilamelanogaster, 4140 transportin Escherichiacoli membranevesicles, 1892 Molecular cloning of DNA fragments produced by restriction Electrodynamics endonucleases SalIl and BamI; 1537 Deep inelasticscattering of chargedleptons, 3816 Multiple pheromone system controlling mating in Drosophila Deep inelasticscattering of leptons, 3351 melanogaster,591 Electrogenicpump Neurophysiological defects in temperature-sensitive paralytic mutants of Neurosporaplasma membrane ATPase is an electrogenicpump, 1485 Drosophilamelanogaster, 3253 Electrolyteanalogue Drosophilapaulistorum Analoguesolution for electricalcapacity of membrane-coveredcubes in Ethological isolation and mating experience in Drosophila paulistorum, cubic arrayat high concentration,4003 975 Electromagneticwave Drosophilapseudoobscura Inverseproblem for convexbodies, 1377 Allelic heterogeneity within allozymes separated by electrophoresis in Electron Drosophilapseudoobscura, 4150 Path of electronsin photosynthesis,4502 Drug action Electrondonation Biological activity of catecholamines covalently linked to synthetic Separationof hydrogenase-catalyzedhydrogen-evolution system from polymers: Immobilized drug theory, 1009 electron-donatingsystem by enzymicelectric cell technique,2947 Biological activity of catecholamines covalently linked to synthetic Electronicanalog model polymers: Immobilized drug theory (correction), 2939 Oscillatoryneuronal circuit generating locomotory rhythm, 3734 Drug biotransformation Electronicrelaxation Interactions between nutritional factors and drug biotransformations in Medium-inducedradiationless transitions and effect of solvent on man, 2501 radiationlesstransitions, 2533 Drug,immobilized Electronicstate Cultured tumor cells: Affinity isolation by drugs and hormones X-ray absorptionedges in iron compoundsand proteins, 1384 covalently bound to glass and Sepharose beads, 2013 Electronmicroprobe Drug-inducedabnormality Fossil microorganismsfrom 2800 to 2500 million-year-oldBulawayan Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced stromatolite:Ultramicrochemical analyses, 2973 abnormality of connective tissue, 2909 Electronmicroscopy Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced see also Freeze-fractureelectron microscopy; Scanning electron abnormality of connective tissue (correction), 4247 microscopy Drug intercalation Adenovirusmessenger RNA mappedby electronmicroscopy, 2069 Ethidium bromide-(dC-dG-dC-dG)2 complex in solution: Intercalation L-Arabinoseoperon: Electron microscopy of gene regulation,1518 and sequence specificity of drug binding at tetranucleotide duplex Catalasemonolayers inactivated by irradiationwith 100 keV electrons, level, 3343 823 Organization of DNA in chromatin, 3068 Cellulosebiosynthesis in Acetobacterxylinum: Visualization of site of Drug metabolism synthesis and direct measurementof in vivo process,4565 Activation of 3':5'-cyclic AMP-dependent protein kinase and induction CircularDNA of yeast episomewith two invertedrepeats: Structural of ornithine decarboxylase as early events in induction of analysisby restrictionenzyme and electronmicroscopy, 3030 mixed-function oxygenases, 1241 Collagenfibrillogenesis: Intermediate aggregates and suprafibrillarorder, Drugresistance 4027 Mouse A9 cell clones differing in malignancy derived in vitro: Analysis Distribution of anionic sites in glomerular basement membranes: Role in by somatic cell hybridization with YACIR lymphoma cell clones, 2004 filtration and attachment, 1646 Duality groups Electron microscopic x-ray microanalysis of normal and leukemic human High dimensional cohomology of discrete groups, 1795 lymphocytes, 3690 Dynamo Electron microscopy of DNA crosslinked with trimethylpsoralen: Moment equation description of magnetic reversals in the earth, 4297 Secondary structure of eukaryotic inverted repeat sequences, 2644 Endoplasmic reticulum: A cytochemist's view (A Review), 2781 Mechanism of genetic recombination: Electron microscopic observation Ear of recombination intermediates, 3000 Caecilian ear, 3744 Nuclear DNA replication in radicles of germinating cotton, 3220 Ear and hearingin Sphenodonpunctatus, 4244 Platinum binds selectively to phosphorothioate groups in mono- and Earth polynucleotides: General method for heavy metal staining of specific Moment equation description of magnetic reversals in the earth, 4297 nucleotides, 2536 Downloaded by guest on October 5, 2021 4738 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Psoralen-crosslinked secondary structure map of single-stranded virus Endorphin DNA, 2649 see also Enkephalin Structural heterogeneity of mitochondrial DNA molecules within the Isolation, primary structure, and synthesis of a-endorphin and genus Drosophila, 3623 -y-endorphin, two peptides of hypothalamic-hypophysial origin with Structure and transformation of chitin synthase particles (chitosomes) morphinomimetic activity, 3942 during microfibril synthesis in vitro, 4570 (-Lipotropin: Prohormone for morphinomimetic peptides endorphins Superstructure of linear duplex DNA, 4125 and enkephalins, 2156 Viroids are single-stranded covalently closed circular RNA molecules M'.-,' ii, nii -ii . ic activity of synthetic fragments of 3-lipotropin and existing as highly base-paired rod-like structures, 3852 Electron probe x-ray analysis (-Endorphin Electron probe x-ray analysis of single ferritin molecules, 1193 (-Endorphin: Cross tolerance to and cross physical dependence on Electron spin resonance morphine, 4187 "Energy upconversion" theory for green plant photosynthesis, 2773 f-Endorphin is a potent analgesic agent, 2895 Electron transfer Opioid activity of a peptide, ,/-lipotropin-(61-91), derived from Charge pair model of bioenergetics: Redox enzymes, 2392 (-lipotropin, 1821 Metalloprotein electron transfer reactions: Reactivity of horse heart Untriakontapeptide with opiate activity from camel pituitary glands, cytochrome c with inorganic complexes, 2950 1145 Model for cytochrome oxidase, 2206 Endosymbiote, bacterial Oxidation of ferrocytochrome c by mitochondrial cytochrome c oxidase, Surface membrane carbohydrate alterations of flagellated protozoan 113 mediated by bacterial endosymbiotes, 852 Electron, valence Energy Ultraviolet photoelectron studies of biological purines: Valence electronic see also Free energy structure of adenine, 2966 Energy gap shift Electrophoresis Medium-induced radiationless transitions and effect of solvent on Allelic heterogeneity within allozymes separated by electrophoresis in radiationless transitions, 2533 Drosophila pseudoobscura, 4150 Energy metabolism Electrophoretic mobility Metabolic mapping of primary visual system of monkey by Electrophoretic distributions of human peripheral blood mononuclear autoradiographic [14C]deoxyglucose technique, 4230 white cells from normal subjects and from patients with acute Energy transduction lymphocytic leukemia, 2388 Electrochemical gradient of protons and its relationship to active Electrophysiology transport in Escherichia coli membrane vesicles, 1892 Innervation of heart cells in culture by endogenous source of cholinergic Energy transfer neurons, 4506 Charge pair model of hbneneretics: Energy transfer, 2770 ' Electrostatic interaction Efficiency of i e .:i; ,i:' i,'ti- i-,i photosystem II to photosystem I in Metalloprotein electron transfer reactions: Reactivity of horse heart Porphyridium cruentum, 3957 cytochrome c with inorganic complexes, 2950 Intramolecular energy transfer and molecular conformation, 271 Elongation factor Radiation effects in living cells: Structural model, 3360 Mechanism of DNA elongation catalyzed by Escherichia coli DNA "Energy upconversion" theory polymerase III, dnaZ protein, and DNA elongation factors I and III, "Energy upconversion" theory for green plant photosynthesis, 2773 3511 Enkephalin Mutant of Escherichia coli with altered elongation factor Tu, 1698 see also (-Endorphin; Endorphin Q3 RNA replicase reconstituted from covalently bonded elongation Antibodies as a means of isolating and characterizing biologically active factor Tu-Ts complex, 1131 substances: Nonpeptide, morphine-like compound in central nervous Rh-^b rr.:rdcn-nident GTPase from yeast distinct from elongation factor system, 2132 Z, it Endogenous opiate analgesic isolated from human blood, 2226 Embryogenesis (-Endorphin: Cross tolerance to and cross physical dependence on Cell cycle analysis and X-chromosome inactivation in developing mouse, morphine, 4187 1608 (-Endorphin is a potent analgesic agent, 2895 Embryonic mammary rudiment (-Lipotropin: Prohormone for morphinomimetic peptides endorphins Tissue interaction in androgen response of embryonic mammary and enkephalins, 2156 rudiment of mouse: Identification of target tissue for testosterone, Morphine-like peptides in mammalian brain: Isolation, structure 4041 elucidation, and interactions with opiate receptor, 2515 Embryo, preimplantation Morphine-like peptides in mammalian brain: Isolation, structure Embryonal carcinoma antigen and T/t locus of mouse, 4080 elucidation, and interactions with opiate receptor (correction), 4247 Encephalomyocarditis virus Morphinomimetic activity of synthetic fragments of (-lipotropin and Competition between cellular and viral mRNAs in vitro is regulated by analogs, 3308 mic.r^-.c-r dizcrimr'nVnoryinitiation factor, 3040 Opioid activity of a peptide, (-lipotropin-(61-91), derived from l]:i.:-'(";:'::il-

Enzyme deficiency Hormonal control of pyruvate kinase activity and of gluconeogenesis in Normal level of adenosine deaminase activity in red cell lysates of isolated hepatocytes, 2762 carriers and patients with severe combined immunodeficiency disease, Episome 104 see also Plasmid Enzyme homogeneity Episome, yeast Negative homotropic cooperativity and affinity heterogeneity: Circular DNA of yeast episome with two inverted repeats: Structural Preparation of yeast glyceraldehyde-3-phosphate dehydrogenase with analysis by restriction enzyme and electron microscopy, 3030 maximal affinity homogeneity, 3928 Epithelium Enzyme, immobilized Distribution of anionic sites in glomerular basement membranes: Role in Immobilization of bacterial luciferase and FMN reductase on glass rods, filtration and attachment, 1646 3848 Epoxide Enzyme induction Enzyme catalyzed covalent binding of benzo[a]pyrene to poly(G), 1117 Metabolic activation of aromatic hydrocarbons in purified rat. liver Hydrocarbon structure in enzyme-catalyzed benzo[a]pyrene-poly(G) nuclei: Induction of enzyme activities and binding to DNA with and covalent complex, 1437 without monooxygenase-catalyzed formation of active oxygen, 457 Epoxide hydratase (EC 4.2.1.63) the Enzyme kinetics Enzymatic conversion of benzo[a]pyrene leading predominantly to Catalytic reaction of penicillinase: Acquisition of substrate-specific diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo- parameters, 1048 [ a]pyrene through a single enantiomer of Defective function of microsomal UDP-glucuronyltransferase in Gunn r-7,t-8-dihydroxy-7,8-dihydrobenzo[a]pyrene, 2594 rats, 289 Epstein-Barr virus Free energy levels and entropy production associated with biochemical Differential effect of phosphonoacetic acid on expression of kinetic diagrams, 95 Epstein-Barr viral antigens and virus production, 1745 Free energy levels and entropy production in muscle contraction and in Epithelial nasopharyngeal carcinoma cells superinfected with related solution systems, 336 Epstein-Barr virus, 960 Free energy levels and entropy production in muscle contraction and in Surface marker characteristics and Epstein-Barr virus studies of two related solution systems (correction), 2165 established North American Burkitt's lymphoma cell lines, 228 Glutamine synthetase from Escherichia coli: Kinetic evidence for two Equation, Laplace reaction intermediates in biosynthetic reaction, 476 Analogue solution for electrical capacity of membrane-covered cubes in Mechanism of action of carboxypeptidase A in ester hydrolysis, 3882 cubic array at high concentration, 4003 Tetrahydrofolate: Cooperative interaction with pig kidney serine Equation of state transhydroxvmethvlase and loss of cooperativity in L1210 tumors and Equation of state describing hydrophobic interactions, 2955 i t issules Iof mice hI'alring these tumors, 1950 van der Waals-type equation of state for fluids with associating Enzyme localization molecules, 1773 Endoplasmic reticulum: A cytochemist's view (A Review), 2781 Erabutoxin b Enzyme marker Three-dimensional structure of erabutoxin b neurotoxic protein: AK1:Np:ABO linkage group assigned to human chromosome 9, 895 Inhibitor of acetylcholine receptor, 2991 Enzyme mechanisms Ergodic theory Mechanism of action of carboxypeptidase A in ester hydrolysis, 3882 Kinetic theory and ergodic properties, 1802 Enzyme microdetermination Erythroblast Distribution of calcitonin-sensitive adenylate cyclase activity along C-type virus particle formation in erythroblastic islands in spleens of rabbit kidney tubule, 3608 C3Hf mice injected with erythropoietin, 3710 Enzyme model Erythrocyte Amine-catalyzed hydrolyses of cyclodextrin cinnamates, 2969 Affinity label for (-adrenergic receptor in turkey erythrocytes, 1921 oscillation Asynchronous synthesis of erythrocyte membrane proteins, 3206 Enzyme be induced in Quantized generation time in mammalian cells as expression of cellular Clustering and endocytosis of membrane receptors can clock, 4012 mature erythrocytes of neonatal but not adult humans, 4075 Erythrocyte membranes undergo cooperative, pH-sensitive state Enzyme polymorphism Evidence from Raman (enetic variability in krill, 658 transitions in physiological temperature range: spectroscopy, 3558 Enzyme, proteolytic inhibited 2767 Role of proteolytic enzymes in biological regulation (A Review), 3825 Erythrocyte phosphate transport by high pressures, Glycosphingolipid content of human pk and p erythrocytes, 3263 Enzyme regulation in Ca2+-mediated crosslinking of erythrocyte Biphasic stimulation of polyamine biosynthesis in primary mouse kidney Intrinsic transglutaminase with virus: from DNA and proteins, 4479 cells by infection polyoma Uncoupling fraction from rRNA 4022 Reconstitution of D-glucose transport catalyzed by protein synthesis, 396 Guanosine 3':5'-cyclic monophosphate binding proteins in rat tissues, human erythrocytes in sonicated liposomes, 2559 Reconstitution of intramembrane particles in recombinants of Effects of Model for hormone-activated adenylate cyclase systems, 1189 erythrocyte protein Band 3 and lipid: spectrin-actin Protein inhibitor to ornithine decarboxylase induced by end products of association, 3891 Sendai-virus-induced its reaction, 1858 Transfer of tRNAs to somatic cells mediated by of coenzyme A reductase activity fusion, 2793 Regulation 3-hydroxy-3-methylglutaryl label of and cholesterol synthesis in nonhepatic tissues of rat, 2564 Virus and lectin agglutination of erythrocytes: Spin study membrane interactions, 3497 Enzyme replacement therapy lipid-protein Enzyme replacement therapy in Gaucher's disease: Purification of Erythrocyte sickling of a thiol reagent, 3288 glucocerebrosidase, 4672 Inhibition erythrocyte sickling by cystamine, Enzyme subunit Erythropoiesis of hexosaminidases A and B: Confirmation of common Asynchronous synthesis of erythrocyte membrane proteins, 3206 Interrelationship formation in islands in of and unique subunit theory, 2833 C-type virus particle erythroblastic spleens C3Hf mice injected with erythropoietin, 3710 Enzyme synthesis differentiation and in Lack of feedback regulation of gene activity and absence of subunit Dimethylsulfoxide-induced hemoglobin synthesis rat cells transformed by exchange between lactate dehydrogenase tetramers in vivo, 3618 tissue cultures of erythroleukemia de novo synthesis of phenylalanine 7,12-dimethylbenz(a)anthracene, 1237 Phytochrome-mediated mouse ammonia-lyase: An approach using pre-induced mustard seedlings, Unequal accumulation of a- and (-globin mRNA in erythropoietic 4017 spleen, 1811 Reserve protein metabolism in cotyledons of mung bean seedlings, 3168 Escherichia coli electric cell Activation of long chain fatty acids with acyl carrier protein: New Enzymic in Escherichia 4374 Separation of hydrogenase-catalyzed hydrogen-evolution system from enzyme, acyl-acyl carrier protein synthetase, coli, electron-donating system by enzymic electric cell technique, 2947 Amplification in Escherichia coli of enzymes involved in genetic Enzymology recombination: Construction of hybrid ColEl plasmids carrying Subcellular localization of S-adenosyl-L-methionine:tRNA structural gene for exonuclease I, 3492 methyltransferases with aminoacyl-tRNA synthetases in human and Bacteriophage T5-induced endonucleases that introduce site-specific mouse: Normal and leukemic leukocytes, 3857 single-chain interruptions in duplex DNA, 1576 from ColEl DNA Epidermal growth factor Biochemical construction of specific chimeric plasmids Hormonal stimulation of DNA synthesis in primary cultures of adult rat and unfractionated Escherichia coli DNA, 3838 hepatocytes, 3589 Change in membrane potential during bacterial chemotaxis, 4387 Induction of human fibroblast proliferation by epidermal growth factor Chemical and enzymatic synthesis of lactose operator of Escherichia coli (EGF): Enhancement by EGF-binding arginine esterase and by and its binding to lactose repressor, 91 ascorbate, 183 Conditional lethal mutants of Escherichia coli defective in transcription Epigenetic control rho, 1959 Clonal variation in albumin messenger RNA activity in hepatoma cells, Cyanobacterial DNA-binding protein related to Escherichia coli HU, 2056 1917 Epilepsy Denatured tRNA2GlUfrom Escherichia coli, 2216 Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced DNA dependent synthesis of protein L12 from Escherichia coli abnormality of connective tissue, 2909 ribosomes, in vitro, 3156 Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced Functional genetic expression of eukaryotic DNA in Escherichia coli, abnormality of connective tissue (correction), 4247 1471 Glutamine synthetase from Escherichia coli: Kinetic evidence for two Epinephrine 476 see also Adrenergic reaction intermediates in biosynthetic reaction, Downloaded by guest on October 5, 2021 4740 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Growth delay induced in Escherichia'coli by near ultraviolet radiation, Primary structure of two cytochromes c2: Close similarity to functionally 59 unrelated mitochondrial cytochrome c, 472 Incorporation of fatty acids containing photosensitive groups into Evolution rate phospholipids of Escherichia coli, 86 Heat mutagenesis in bacteriophage T4: Transition pathway, 1269 Induction of sigma factor synthesis in Escherichia coli by the N gene Excision repair product of bacteriophage lambda, 4405 Deficiency of gamma-ray excision repair in skin fibroblasts from patients Low resolution model for 50S subunit of Escherichia coli ribosomes, with Fanconi's anemia, 2419 2379 Recombination in 'a, ,rkrf^.'-. rQ cerevisiae: DNA repair mutation Mutant of Escherichia coli with altered elongation factor Tu, 1698 associated with (.l.xIi(.I ( il ic:.; gene conversion, 2828 Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by Excited singlet state DNA gyrase, 4474 Retinal has highly dipolar vertically excited singlet state: Implications Prokaryotic DNA visualized in a regularly condensed chromatin-like for vision, 2169 fiber, 563 Exocytosis recA protein of Escherichia coli K-12: Identification and radiochemical Freeze-fracture study of mast cell secretion, 2823 purification, 3979 Exonuclease Recombination promoted by superhelical DNA and recA gene of Amplification in Escherichia coli of enzymes involved in genetic Escherichia coli, 3910 recombination: Construction of hybrid COlEI plasmids carrying Regulation of ornithine decarboxylase activity by guanine nucleotides: In structural gene for exonuclease 1, 3492 vivo test in potassium-depleted Escherichia coli, 3502 Endonuclease II, apurinic acid endonuclease, and exonuclease III, 4324 Ribosomal proteins of Escherichia coli that stimulate Extinction stringent-factor-mediated pyrophosphoryl transfer in vitro, 1839 Calculation of immigration and extinction curves from Specialized transduction of colicin El DNA in Escherichia coli K-12 by species-area-distance relation, 4130 phage lambda, 3238 Group selection among laboratory populations of Tribolium castaneum, Specific in situ cleavage of 16S ribosomal RNA of Escherichia coli 4604 interferes with function of initiation factor IF-1, 702 Eye Stereochemistry of polymerization by DNA-dependent RNA polymerase see also Cell, retinal; Lens; Optic Retina, Visual Escherichia coli: of nerve; embryonic; from Use diastereomeric ATP-analogue, 2987 pigment; Visual system factor from Escherichia coli directs ribosomal and Stringent binding Blood-aqueous barrier can be circumvented by lowering intraocular release of uncharged tRNA, 0707 pressure, 638 Structure of L-arabinose-binding protein from Escherichia coli at 5 A Synthesis of type II collagen in vitro by embryonic chick neural retina resolution and preliminary results at 3.5 A, 2186 tissue, 4420 Suppression of lytic effect of beta lactams on Escherichia coli and other bacteria, 3293 Escherichia coli Hfr F prime factors able to replicate in Escherichia coli Hfr strains, 198 Facultative methylotrophy Escherichia coli K-12 Anaerobic growth of a Rhodopseudomonoas species in dark with carbon Molecular cloning of DNA from F sex factor of Escherichia coli K-12, 64 monoxide as sole carbon and energy substrate, 3298 Escherichia coli minicell Familial hypercholesterolemia Synthesis of R plasmid protein associated with tetracycline resistance is see also Homozygous familial hypercholesterolemia negatively regulated, 1509 Alterations in cell surface glycosphingolipids and other lipid classes of Esterase-5 fibroblasts in familial hypercholesterolemia, 4339 Allelic heterogeneity within allozymes separated by electrophoresis in Fanconi's anemia Drosophila pseudoobscura, 4150 Deficiency of gamma-ray excision repair in skin fibroblasts from patients Ester hydrolysis with Fanconi's anemia, 2419 Mechanism of action of carboxypeptidase A in ester hydrolysis, 3882 Hemoglobin Wayne: Frameshift mutation detected in human Estrogen hemoglobin alpha chains, 882 Alpha-fetoprotein: Major high-affinity estrogen binder in rat uterine Fate mapping cytosols, 1452 Courtship in Drosophila mosaics: Sex-specific foci for sequential action Induction of vitellogenin synthesis by estrogen in avian liver: patterns, 4154 Relationship between level of vitellogenin mRNA and vitellogenin Fatty acid synthesis, 1442 Activation of long chain fatty acids with acyl carrier protein: New Estrous cycle enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli, 4374 Circadian organization of estrous cycle of golden hamster, 2923 Acyl coenzyme A synthetase activity is required for repression of yeast Ethanolamine acetyl coenzyme A carboxylase by exogenous fatty acids, 386 Choline synthesized from ethanolamine in rat brain, 2181 Adenylate cyclase activity in LM cells by modified manipulation of Ethenonucleotide membrane phospholipid composition in vivo, 4482 l,NA-Etheno-AMP and 1,N6-etheno-2'-deoxy-AMP as probes of activator Incorporation of fatty acids containing photosensitive groups into site of glycogen phosphorylase from rabbit skeletal muscle, 2696 phospholipids of Escherichia coli, 86 Ethidium bromide Influence of polyunsaturated fatty acids on survival of skin allografts Ethidium bromide.(dC-dG-dC-dG)2 complex in solution: Intercalation and tumor incidence in mice, 928 and sequence specificity of drug binding at tetranucleotide duplex Modulation of membrane fluidity: Homogeneous catalytic hydrogenation level, 3343 of phospholipids and phospholipid-water model biomembranes, 3971 Superstructure of linear duplex DNA, 4125 Fatty acid synthetase Ethylpurine, 2,6-diamino-9- Specific release of thioesterase component of fatty acid synthetase Crystal structure of complex between lumiflavin and multienzyme complex by limited trypsinization, 1184 2,6-diamino-9-ethylpurine: Flavin adenine dinucleotide model Fatty acyl-CoA exhibiting charge-transfer interactions, 3807 Fatty acyl-CoA oxidizing system in rat liver peroxisomes: Enhancement Etioplast by clofibrate, a hypolipidemic drug, 2043 Localization of phytochrome in etioplasts and its regulation in vitro of Favorskii-Nazarov reaction gibberellin levels, 138 Favorskii-Nazarov reaction of dicyclopropyl ketone, 2945 Euclidean harmonic analysis Feedback regulation Maximal function associated to curve (t, t2), 1416 Lack of feedback regulation of gene activity and absence of subunit Euglena exchange between lactate dehydrogenase tetramers in vivo, 3618 Euglena chloroplast tRNAs: Transcriptional origin, 1984 Fermi golden rule Euglena gracilis Medium-induced radiationless transitions and effect of solvent on Growth conditions influence number of chloroplast DNA molecules in radiationless transitions, 2533 Euglena gracilis, 2401 Ferritin Evolution Differential labeling of cell surface of single ciliary ganglion neurons in Biliproteins of cyanobacteria and Rhodophyta: Homologous family of vitro, 4100 photosynthetic accessory pigments, 428 Electron probe x-ray analysis of single ferritin molecules, 1193 Evolution of continuous variation: Direct approach through joint Translational conitrol in regulation of ferritin synthesis by iron, 857 distribution of genotypes and phenotypes. 1689 Ferritin-lectin conjugate Evolution, population dynamics, 1and stllailily. 665 Clustering and endocytosis of membrane receptors can be induced in Fossil microorganisms from 2800 to 2500 million-year-old Bulawayan mature erythrocytes of neonatal but not adult humans, 4075 stromatolite: Ultramicrochemical analyses, 2973 Fertility control Evolution, chromosomal Immunological block to mammalian fertilization: Survival and organ Rates of evolution in seed plants: Net increase in diversity of distribution of immunoglobulin which inhibits fertilization in vivo chromosome numbers and species numbers through time, 2086 2405 Evolution,gene Fertilization, mammalian Genetically transmitted retravirus isolated from Mus cervicolor, 3579 Immunological block to mammalian fertilization: Survival and organ Nucleotide sequences in mouse DNA and RNA specific for Moloney distribution of immunoglobulin which inhibits fertilization in vivo sarcoma virus, 3705 2405 Evolution,human Fertilization,self Rates, patterns, and effectiveness of evolution in multi-level situations, Homozygous mutants isolated after induced self-fertilization in 1360 Tetrahymena, 3243 Evolution,molecular Fetal development Characterization of 80-million-year-old mollusk shell proteins, 2541 Inhibitory effect of human alpha-fetoprotein on in vitro transformation of human lymphocytes, 2857 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4741

a-Fetoprotein Flagellin Alpha-fetoprotein:Major high-affinity estrogen binder in rat uterine 3':5'-CyclicGMP derivatives:Effect on formationof Caulobactersurface cytosols, 1452 structures,3303 Humanalpha-fetoprotein as modulatorof humanlymphocyte Flagellum transformation:Correlation of biologicalpotency with electrophoretic Tubulin requirestau for growthonto microtubuleinitiating sites, 4070 variants,4645 Flavin adeninedinucleotide Immunologicalcrossreaction between alpha-fetoprotein and albumin, Crystalstructure of complexbetween lumiflavin and 4641 2,6-diamino-9-ethylpurine:Flavin adeninedinucleotide model Inhibitoryeffect of humanalpha-fetoprotein on in vitro transformation exhibitingcharge-transfer interactions, 3807 of humanlymphocytes, 2857 Flavin mononucleotidereductase Fetus Immobilizationof bacterialluciferase and FMN reductaseon glass rods, Changes in levels of cellular retinol- and retinoic-acid-binding proteins of 3848 liver and lung duringperinatal development of rat, 3976 Flavoprotein-linkedmonooxygenase (EC 1.14.14.1) Feulgen-positivegranule Locusrequired for flavoprotein-linkedmonooxygenase expression Localizationby in situ hybridizationof amplifiedribosomal DNA during assignedto humanchromosome 2, 4628 Xenopus laevis oocyte maturation(light and electronmicroscopy Flowering study), 833 Metabolicindicator of photoperiodictiming, 501 Fibrinolysis Fluctuationspectroscopy Involvementof high molecularweight kininogenin surface-dependent Molecularweights determinedby fluctuationspectroscopy: Application reactionsof Hagemanfactor, 2554 to DNA, 2776 Fibroblast Fluidity see also Cell culture,fibroblast Viscosityof dilute gases and vapors,4302 Abnormallevels of 3':5'-cyclicAMP in isoproterenol-stimulated Fluids with associatingmolecules fibroblastsfrom patients with cystic fibrosis,2899 van der Waals-typeequation of state for fluids with associating Active cell edge and movementsof concanavalinA receptorsof surfaceof molecules,1773 epithelialand fibroblasticcells, 4085 Fluorescamine Adenylatecyclase activity in LM cells by modifiedmanipulation of Diabetogenicpeptide from humangrowth hormone: Partial purification membranephospholipid composition in vivo, 4482 from peptic digest and long-termaction in ob/ob mice, 4706 Alteredapurinic DNA endonucleaseactivity in groupA and groupD Fluorescence xerodermapigmentosum fibroblasts, 1169 See also Cytofluorometry;Immunofluorescence Calcium-dependentregulatory protein of cyclic nucleotidemetabolism in Biologicalmolecules identified in situ at high resolutionvia fluorescence normaland transformedchicken embryo fibroblasts, 2711 excited by scanningelectron beam, 317 Cell surfaceprotein partially restores morphology, adhesiveness, and Choleratoxin interactionswith thyrotropinreceptors on thyroidplasma contact inhibitionof movementto transformedfibroblasts, 1217 membranes,1679 Decreasedfidelity of DNA polymeraseactivity isolated from aging Energy-dependentbinding of dansylgalactosideto lac carrierprotein: humanfibroblasts, 2818 Direct bindingmeasurements, 109 Deficiencyof gamma-rayexcision repairin skin fibroblastsfrom patients 1,N6-Etheno-AMPand 1,N6-etheno-2'-deoxy-AMPas probesof activator with Fanconi'sanemia, 2419 site of glycogenphosphorylase from rabbitskeletal muscle, 2696 Functionalincorporation of gangliosideinto intact cells: Inductionof Fluorescence-detectedmagnetic circular dichroism of fluorescentand choleragenresponsiveness, 1034 nonfluorescentmolecules, 276 Humanchromosome 3 releasesblock at Gi of cell cycle, in hybrids Hydrocarbonstructure in enzyme-catalyzedbenzo[a]pyrene-poly(G) betweentsAF8 hamsterand humancells, 2052 covalentcomplex, 1437 Inductionof humanfibroblast proliferation by epidermalgrowth factor Hydrolysisand transpeptidationof peptide substratesby acetyl-pepsin, (EGF):Enhancement by EGF-bindingarginine esterase and by 3915 ascorbate,183 Lateralmotion of fluorescentlylabeled acetylcholinereceptors in Inhibitionof arachidonicacid release fromcells as biochemicalaction of membranesof developingmuscle fibers, 4594 anti-inflammatorycorticosteroids, 1730 Redox titrationof fluorescenceyield of photosystemII, 2211 Interferon:Purification and initial characterizationfrom humandiploid Solid phase synthesis of proteinactivator for lecithin-cholesterol cells, 520 acyltransferasecorresponding to humanplasma apoC-I, 1422 Long-chainneutral glycolipids and gangliosidesof murinefibroblast Verticaldisplacement of membraneproteins mediated by changesin lines and their low- and high-tumorigenichybrids, 1568 microviscosity,4526 Low density lipoproteinreceptors localized on plasmamembrane of Fluorescenceanisotropy normalhuman fibroblasts and their absencein cells from familial Affinityof myosin S-1 for F-actin, measuredby time-resolved hypercholesterolemiahomozygote, 2434 fluorescenceanisotropy, 133 Menkesdisease: Biochemical abnormality in culturedhuman fibroblasts, Affinity of myosinS-1 for F-actin, measuredby time-resolved 604 fluorescenceanisotropy (correction), 2527 MessengerRNA competitionin shutoff of humaninterferon production, Fluorescencedepolarization 1621 Affinity of myosin S-1 for F-actin, measuredby time-resolved Microfilamentorganization and surfacetopography: Changes upon fluorescenceanisotropy, 133 transformationof chick embryofibroblasts with Rous sarcomavirus, Affinityof myosinS-1 for F-actin,measured by time-resolved 4065 fluorescenceanisotropy (correction), 2527 Mutantsof Balb/c 3T3 fibroblastsdefective in adhesivenessto Fluorinemagnetic resonance substratum:Alteration in cell surfaceproteins, 544 Innerand outer hydrocarbonchains of lipid bilayervesicles: Direct Organizationand energy-dependentgrowth of microtubulesin cells, 2798 spectroscopicobservation, 2716 Purineauxotroph deficient in phosphoribosylpyrophosphate Fluorocarbonfluid amidotransferaseand phosphoribosylpyrophosphateaminotransferase Direct determinationof surfacetension in lung, 4698 activities with normalactivity of ribose-5-phosphateaminotransferase, 5-Fluorocytidine 2458 Incorporationof 5-fluorocytidinein RNA of 5-fluorouracil-treated Regulationof active a-aminoisobutyricacid transportexpressed in eukaryoticcells, 1528 membranevesicles frommouse fibroblasts,2614 Fluorometricassay Selenium:Essential trace nutrient for growthof WI-38diploid human Fluorometricassay of vasopressinand oxytocin:Assay of peptides in fibroblasts,2023 tissues, 1314 Simultaneoussynthesis of types I and III collagenby fibroblastsin 5-Fluorouracil culture,4037 Incorporationof 5-fluorocytidinein RNA of 5-fluorouracil-treated Synthesis of nuclearproteins during DNA repairsynthesis in human eukaryoticcells, 1528 diploid fibroblastsdamaged with ultravioletradiation or Fluvial geomorphology N-acetoxy-2-acetylaminofluorene,1466 Bedload measurements,East Fork River,Wyoming, 1000 Temperature-sensitivechanges in surfacemodulating assemblies of Folate bindingfactor fibroblaststransformed by mutants of Rous sarcomavirus, 2047 Purificationof folate bindingfactor in normalumbilical cord serum, Fibroblast-derivedgrowth factor 2527 Clonalgrowth of bovine vascularendothelial cells: Fibroblastgrowth Folic acid factoras survivalagent, 4120 see also Tetrahydrofolate Polypeptideof 18,000molecular weight inducesearly events and In vivo rates of methioninebiosynthesis in transformedhuman and stimulatesDNA synthesis in culturedcells, 4555 malignantrat cells auxotrophicfor methionine,1523 Fibroblast,Lesch-Nyhan Food contamination Growthof humandiploid fibroblastsin absenceof glucoseutilization, Screeningby negativechemical ionization mass spectrometryfor 4110 environmentalcontamination with toxic residues:Application to Fibrosis humanurines, 1777 Diphenylhydantoin(Dilantin) gingival hyperplasia: Drug-induced Fossil microorganism abnormalityof connectivetissue, 2909 Fossil microorganismsfrom 2800 to 2500 million-year-oldBulawayan Diphenylhydantoin(Dilantin) gingival hyperplasia: Drug-induced stromatolite:Ultramicrochemical analyses, 2973 abnormalityof connectivetissue (correction),4247 Fossil protein VitaminA-containing lipocytes and formationof type III collagenin Characterizationof 80-million-year-oldmollusk shell proteins,2541 liver injury,3719 Fossil record Filament,muscle Rates of evolutionin seed plants:Net increasein diversityof Immunologicalcharacterization of subunit of 100 A filamentsfrom chromosomenumbers and species numbersthrough time, 2086 muscle cells, 4344 Free energy Chargepair model of bioenergetics:Redox enzymes,2392 Free energylevel Free energylevels and entropyproduction associated with biochemical Downloaded by guest on October 5, 2021 4742 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

kinetic diagrams, 95 Interrelationship of hexosaminidases A and B: Confirmation of common Free energy levels and entropy production in muscle contraction and in and unique subunit theory, 2833 related solution systems, 336 Gas Free energy levels and entropy production in muscle contraction and in Viscosity of dilute gases and vapors, 4302 related solution systems (correction), 2165 Gastrointestinal nerve Free energy transduction Vasoactive intestinal polypeptide localized to central and peripheral Ct,i-,O,-^,tc- kinetic formalism applied to multienzyme complexes, neurons, 3197 . -' ;(:;i'ix phosphorylation, and interacting enzymes, 4432 Gaucher's disease Freeze-etching Enzyme replacement therapy in Gaucher's disease: Purification of Cellulose microfibrils: Visualization of biosynthetic and orienting glucocerebrosidase, 4672 complexes in association with plasma membrane, 143 Gauss-Manin connection Freeze-fracture Bernstein polynomials and Milnor algebras, 2546 Analysis of membrane halves: Cholesterol, 173 Gel electrophoresis Fluidity in mitochondrial membranes: Thermotropic lateral translational Determination of number of superhelical turns in simian virus 40 DNA motion of intramembrane particles, 1636 by gel electrophoresis (correction), 2527 Photosynthetic unit in lettuce, 4560 Gene A Freeze-fracture electron microscopy Alterations in surface glycoproteins and level of sialyltransferase of cells Freeze-fracture study of mast cell secretion, 2823 transformed by temperature-sensitive mutant of simian virus 40, 4090 Freezing of organs Autoregulation of simian virus 40 gene A by T antigen, 3083 Survival of fetal rat pancreases frozen to -78 and -196?, 4105 Isolation and characterization of protein coded by gene A of Friend virus bacteriophage 4X174 DNA, 2669 see also Leukemia virus, Friend Gene, Adh I)imethylsulfoxide-induced differentiation and hemoglobin synthesis in Regulation of expression of Adh genes in maize, 582 tissue cultures of rat erythroleukemia cells transformed by Gene Bvr-1 7,12-dimethylbenz(a)anthracene, 1237 Bvr-1, a restriction locus of a type-C RNA virus in feline cellular Frog genome: Identification, location, and phenotypic characterization in see Rana pipiens cat X mouse somatic cell hybrids, 4618 Fructose 1,6-bisphosphatase (EC 3.1.3.11) Gene cI Zn2+ as inhibitor and activator of fructose 1,6-bisphosphatase of rat Construction of plasmids carrying the cI gene of bacteriophage X, 4174 liver, 2692 Gene dnaZ a-L-Fucosidase (EC 3.2.1.51) Escherichia coli dnaZ gene product involved in DNA elongation in vitro, Specific recognition sites mediating clearance of lysosomal enzymes in 1053 vivo, 4045 Escherichia coli dnaZ gene product involved in DNA elongation in vitro Fuel, nonpolluting (correction), 2939 Separation of hydrogenase-catalyzed hydrogen-evolution system from Gene Fv-1 electron-donating system by enzymic electric cell technique, 2947 Fv-1 gene product: Effect on proviral DNA formation and integration in g-Function cells infected with murine leukemia viruses, 2236 Maximal functions: Homogeneous curves, 2176 Host restriction of Friend leukemia virus: Synthesis and integration of Maximal functions: Spherical means, 2174 provirus, 2356 Relation between automorphic forms on GL(2) and GL(3), 3348 Gene, H-2 Papain cleavage site of H-2 glycoproteins, 915 Gene, mot ,-D-1,6-Galactans mot gene product identified with Escherichia coli-lambda hybrids, 3126 Subunit interactions in mouse myeloma proteins with anti-galactan gene, recA activity, 932 recA protein of Escherichia coli K-12: Identification and radiochemical Galactic dynamics purification, 3979 Unstable spiral modes in disk-shaped galaxies: Enhancement of growth Recombination promoted by superhelical DNA and recA gene of rate, 3785 Escherichia coli, 3910 Galactokinase (EC 2.7.1.6) Gene src Two linked human genes cotransfer red into cultured mouse cells, 1274 Microfilament organization and surface topography: Changes upon Galactose oxidase transformation of chick embryo fibroblasts with Rous sarco-ma virus, Alterations in cell surface glycosphingolipids and other lipid classes of 4065 fibroblasts in familial hypercholesterolemia, 4339 Gene, suA Galactose oxidase (EC 1.1.3.9) Regulation of p and a subunit of RNA polymerase in Relationship of gangliosides to structure and function of thyrotropin Escherichia coli B/r, 2285 receptors: Their absence on plasma membranes of thyroid tumor Gene activity defective in thyrotropin receptor activity, 4060 Lack of feedback regulation of gene activity and absence of subunit (3-Galactosidase exchange between lactate dehydrogenase tetramers in vivo, 3618 Catabolite modulator factor: Mediator of catabolite repression in Gene amplification bacteria, 3476 AKR-specific sequences increased in tumor tissues of leukemic AKR Functional repressor parts of tetrameric lac repressor-,f-galactosidase mice, 2448 chimera are organized as dimers, 3529 Germ line integration and Mendelian transmission of exogenous Identification of recombinants of phage X, 3394 Moloney leukemia virus, 1260 (3-Galactosidase (EC 3.2.1.23) Intracellular precursor to DNA excreted by human lymphocytes, 3211 (-Galactosidase converted to membrane-bound state by gene fusion, Gene competition 3423 Regulation of expression of Adh genes in maize, 582 Specific binding of formylated initiator-tRNA to Escherichia coli RNA Gene conversion polymerase, 3064 Repair tracts in mismatched DNA heteroduplexes, 4135 Galactosyltransferase Gene conversion, mitotic Cancer-associated isoenzyme of serum galactosyltransferase, 1319 Recombination in Saccharomyces cerevisiae: DNA repair mutation Galaxy associated with elevated mitotic gene conversion, 2828 Unstable spiral modes in disk-shaped galaxies, 1379 Gene, duplicated Unstable spiral modes in disk-shaped galaxies: Enhancement of growth Hydrophobicity of NH2-terminal extra piece of immunoglobulin rate, 3785 light-chain precursors: Physiological functions of extra piece, 3273 Ganglion Immunoglobulin allotypes of rabbit kappa chains: Polymorphism of Effects of persistent selective suppression of ganglionic control mechanism regulating closely linked duplicated genes? 1293 butyrylcholinesterase on steady state and regenerating levels of Gene expression acetylcholinesterase: Function of butyrylcholinesterase and regulation Nitrofurans, a group of synthetic antibiotics, with a new mode of action: of protein synthesis, 2936 Discrimination of specific messenger RNA classes, 3386 Ganglioside Plasmid cloning vehicle allowing regulated expression of eukaryotic DNA Choleragen-mediated release of trapped glucose from liposomes in bacteria, 3900 containing ganglioside GMl, 3480 Gene function Cholera toxin interactions with thyrotropin receptors on thyroid plasma Localization of gene functions in polyoma virus DNA, 4169 membranes, 1679 Gene fusion Functional incorporation of ganglioside into intact cells: Induction of 3-Galactosidase converted to membrane-bound state by gene fusion, choleragen responsiveness, 1034 3423 Long-chain neutral glycolipids and gangliosides of murine fibroblast Gene, hemagglutinin lines and their low- and high-tumorigenic hybrids, 1568 Mapping of influenza virus genome: Identification of hemagglutinin and Relationship of gangliosides to structure and function of thyrotropin neuraminidase genes, 2142 receptors: Their absence on plasma membranes of thyroid tumor Gene, human defective in thyrotropin receptor activity, 4060 Two linked human genes cotransfer red into cultured mouse cells, 1274 Thyrotropin and cholera toxin used to probe mechanism by which Gene, immunoglobulin interferon initiates antiviral activity, 3695 Somatic rearrangement of immunoglobulin genes coding for variable and Thyrotropin-ganglioside interactions and relationship to structure and constant regions, 3628 function of thyrotropin receptors, 842 Gene, immunoglobulin heavy chain Gangliosidosis Immunoglobulin variant: -y3 heavy chain disease protein CHI, 1552 Heteropolymeric hexosaminidase A in human x mouse hybrid cells, 3637 Gene, immunoglobulin kappa light chain Transcription in vitro of immunoglobulin kappa light chain genes in Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4743

isolated mouse myelomanuclei and chromatin,775 Genetic deletion Gene, immunoglobulinlight chain HemoglobinWayne: Frameshift mutation detected in human Reiterationfrequency of immunoglobulinlight chain genes:Somatic hemoglobinalpha chains,882 generationof antibodydiversity, 203 Genetic disease Gene insertion Abnormallevels of 3':5'-cyclicAMP in isoproterenol-stimulated Idiotypicantigen on monoclonalcold agglutininand on its isolatedheavy fibroblastsfrom patients with cystic fibrosis,2899 and light chains, 1702 Abnormalornithine carbamoyltransferase in mice havingsparse-fur Molecularcloning of DNA fragmentsproduced by restriction mutation,1693 endonucleasesSalIl and BamI, 1537 Androgeninsensitivity in man:Genetic heterogeneity,891 Gene isolation Defective thymine dimerexcision by cell-freeextracts of xeroderma Methodfor cloningeukaryotic structural gene sequences,3146 pigmentosumcells, 2757 Gene localization Mucopolysaccharidoses(A Review),630 AK1:Np:ABOlinkage group assigned to humanchromosome 9, 895 Mucopolysaccharidoses(A Review) (correction),2165 Gene mapping Normallevel of adenosinedeaminase activity in red cell lysates of Adenovirusmessenger RNA mappedby electronmicroscopy, 2069 carriersand patients with severe combinedimmunodeficiency disease, Envelope-specificand sarcoma-specificnucleotide sequences from 104 differentparents in RNAs of avian tumor virus recombinants,1073 Purine metabolismin adenosinedeaminase deficiency, 2867 Genetic analysisof transposablesuppressor gene in Saccharomyces Geneticdistance cerevisiae,4623 Infinite allele model with varyingmutation rate, 4164 Hybridizationof RNA to double-strandedDNA: Formationof R-loops, Geneticfounder effect 2294 Competitiveinterdeterminacy in Tribolium,1368 Locationof envelope-specificand sarcoma-specificoligonucleotides on Geneticheterogeneity RNA of Schmidt-RuppinRous sarcomavirus, 447 Humanpapilloma virus DNA: Physical mappingand genetic Mappingof influenzavirus genome:Identification of hemagglutininand heterogeneity,1310 neuraminidasegenes, 2142 Porphyriavariegata and porphyriacutanea tarda in siblings:Chemical Gene, mitochondrial and genetic aspects (Addendum),1323 Biogenesisof mitochondria:Molecular mapping of mitochondrialgenome Geneticlinkage of yeast, 2082 Heredityof Gix thymocyteantigen associatedwith murineleukemia Gene, neuraminidase virus:Segregation data simulatinggenetic linkage,2077 Mappingof influenzavirus genome:Identification of hemagglutininand Geneticmosaicism neuraminidasegenes, 2142 Totipotencyand normaldifferentiation of single teratocarcinomacells Gene, ovalbumin cloned by injectioninto blastocysts,549 Selective digestionof transcriptionallyactive ovalbumingenes from Geneticpolymorphism oviduct nuclei, 3966 Allelic heterogeneitywithin allozymesseparated by electrophoresisin Gene product Drosophilapseudoobscura, 4150 Humanliver and placentalalkaline phosphatase isoenzymes are coded Genetic polymorphismof IgD-likecell surfaceimmunoglobulin in mouse, by differentgenes, 2201 1305 Generationtime Geneticrecombination Quantizedgeneration time in mammaliancells as expressionof cellular Amplificationin Escherichiacoli of enzymesinvolved in genetic clock, 4012 recombination:Construction of hybridColEl plasmidscarrying Gene regulation structuralgene for exonucleaseI, 3492 Amplificationof moderatelyrepetitive DNA sequencesduring chick Geneticrecombination of bacteriophageT7 DNA in vitro, 692 , .!.:-l < i!lii ,(-i:( l iil. . 3428 Mechanismof genetic recombination:Electron microscopic observation L-Arabinoseoperon: Electron microscopy of gene regulation,1518 of recombinationintermediates, 3000 Chemicaland enzymaticsynthesis of lactose operatorof Escherichiacoli Modifiedrecombination and transmissionof mitochondrialgenetic and its bindingto lactose repressor,91 markersin rho minus mutants of Saccharomycescerevisiae, 4608 Expressionof humanand suppressionof mouse nucleolusorganizer Restrictionassay for integrativerecombination of bacteriophageX DNA activity in mouse-humansomatic cell hybrids,4531 in vitro:Requirement for closed circularDNA substrate,3524 Independentregulation of endogenousand exogenousavian RNA tumor Single burst study of rec- and red-mediatedrecombination in virus genes, 2259 bacteriophagelambda, 4613 Inductionof mouse type-C virus by translationalinhibitors: Genetics Transcriptionalderepression of specific class of endogenousvirus, 4541 see also Populationgenetics; Somatic cell genetics Gene, regulatory Genetics,developmental Deficiencyin plasmaprotein synthesis causedby x-ray-inducedlethal Embryonalcarcinoma antigen and Tit locus of mouse, 4080 albino alleles in mouse,3376 Genetic selection Gene reiteration Evolutionof continuousvariation: Direct approachthrough joint No detectablereiteration of genes coding for mouse MOPC41 distributionof genotypesand phenotypes,1689 immunoglobulinlight-chain mRNA, 727 Genetictransmission Gene, R factor Germline integrationand Mendeliantransmission of exogenous Transpositionof R factorgenes to bacteriophageX (correction),977 Moloneyleukemia virus, 1260 Gene selection Modifiedrecombination and transmissionof mitochondrialgenetic Functionalgenetic expressionof eukaryoticDNA in Escherichiacoli, markersin rho minus mutants of Saccharomycescerevisiae, 4608 1471 Geneticvariability Gene, silent Androgeninsensitivity in man:Genetic heterogeneity, 891 Analysisof HeLa cell hypoxanthinephosphoribosyltransferase mutants Genetic variabilityin krill, 658 and revertantsby two-dimensionalpolyacrylamide gel electrophoresis: Geneticvariation in serumlow density lipoproteinsand lipid levels in Silent gene activation,4589 man, 937 Gene, structural Multiplepheromone system controllingmating in Drosophila Amplificationin Escherichiacoli of enzymesinvolved in genetic melanogaster,591 recombination:Construction of hybridColEl plasmidscarrying Gene transcription structuralgene for exonucleaseI, 3492 Dephosphorylationof nonhistoneproteins specifically alters patternof Chickcytoplasmic actin and muscle actin have differentstructural genes, gene transcriptionin reconstitutedchromatin, 1174 2346 Orderof transcriptionof genes of vesicularstomatitis virus,442 Method for cloningeukaryotic structural gene sequences,3146 Sequentialtranscription of genes of vesicularstomatitis virus, 1504 Gene, suppressor Gene transfer Geneticanalysis of transposablesuppressor gene in Saccharomyces BacteriophageT3 and T7 early RNAs are translatedby eukaryotic80S cerevisiae,4623 ribosom'es:Active phageT3 coded S-adenosylmethioninecleaving Gene, tandemduplication of enzymeis synthesized,2752 Radiation-inducedmutations at mouse hemoglobinloci, 2843 Chromosome-mediatedgene transferbetween closely related strainsof Gene, thymidylatesynthetase culturedmouse cells, 2838 Expressionof thymidylatesynthetase gene of Bacillus subtilis Two linked humangenes cotransferred into culturedmouse cells, 1274 bacteriophagePhi-3-T in Escherichiacoli, 4145 Gene, variableregion Geneticcode Humanand murinephosphorylcholine-binding immunoglobulins: Evolutionof universalgenetic code, 2336 Conservedsubgroup and first hypervariableregion of heavy chains, Geneticcontrol of susceptibilityto virus 2096 Gene locus modifyingsusceptibility to certainB-tropic murineleukemia Gene, viral viruses,585 Orderof transcriptionof genes of vesicularstomatitis virus,442 Geneticdefect Sequentialtranscription of genes of vesicularstomatitis virus, 1504 Carcinogensas mutagensin Salmonella/microsometest: Assay of 300 Genotypicmarker chemicals,950 Mismatchedbase-pair regions in polyomaheteroduplex DNA: Fate Molecularabnormality of humanalphal-antitrypsin variant (Pi-ZZ) duringinfection of mouse cells, 3073 associatedwith plasmaactivity deficiency,1324 Geology Residualenzyme activity in fibroblastsfrom patients with adenosine Bedload measurements,East Fork River,Wyoming, 1000 deaminasedeficiency and combinedimmunodeficiency: Evidence for Characterizationof 80-million-year-oldmollusk shell proteins, 2541 mutant enzyme,213 Geophysics Geneticdeficiency, mammalian Momentequation description of magneticreversals in the earth,4297 Defectivefunction of microsomalUDP-glucuronyltransferase in Gunn Germline integration rats, 289 Germline integrationand Mendeliantransmission of exogenous Downloaded by guest on October 5, 2021 4744 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Moloney leukemia virus, 1260 -y-Glutamylcycle Gibberellin Glutathioneand -y-glutamylcycle enzymesin crypt and villus tip cells of Localization of phytochrome in etioplasts and its regulation in vitro of rat jejunalmucosa, 420 gibberellin levels, 138 -y-Glutamylcyclotransferase Gibbonape Glutathioneand y-glutamylcycle enzymesin crypt and villus tip cells of see Hylobates lar rat jejunalmucosa, 420 Giemsabanding -y-Glutamyl-cysteinesynthetase Human chromosome 3 releases block at G1 of cell cycle, in hybrids Glutathioneand -y-glutamylcycle enzymesin crypt and villus tip cells of between tsAF8 hamster and human cells, 2052 rat jejunalmucosa, 420 Gingivalhyperplasia y-Glutamyltranspeptidase Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced y-Glutamyltranspeptidase, a lymphoidcell-surface marker: Relationship abnormality of connective tissue, 2909 to blastogenesis,differentiation, and neoplasia,2414 Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced Subunit structureand isozymicforms of -y-glutamyltranspeptidase, 2599 ;lI)roi llillii' yl connective( tissue (correction), 4247 Glutathione Gliadinprotein component Glutathioneand -y-glutamylcycle enzymesin crypt and villus tip cells of Gliadin protein components: Relationship to chromosomes in hexaploid rat jejunalmucosa, 420 wheats (Triticum aestivum L.), 3646 Hydrogendonor system for Escherichiacoli ribonucleoside-diphosphate Globin reductasedependent upon glutathione,2275 Stepwise biosynthesis in vitro of globin genes from globin mRNA by Subunitstructure and isozymicforms of -y-glutamyltranspeptidase, 2599 DNA polymerase of avian myeloblastosis virus, 3418 Glutathionesynthetase Globin synthesis Glutathioneand -y-glutamylcycle enzymesin crypt and villus tip cells of Erythroid cell differentiation: Murine erythroleukemia cell variant with rat jejunalmucosa, 420 unique pattern of induction by polar compounds, 1232 Glyceraldehyde-phosphatedehydrogenase (EC 1.2.1.12) Trimodality in proportion of hemoglobin G Philadelphia in Negativehomotropic cooperativity and affinity heterogeneity: heterozygotes: Heterogeneity in number of human alpha chain loci, Preparationof yeast glyceraldehyde-3-phosphatedehydrogenase with 3633 maximalaffinity homogeneity,3928 Globoside Glycine Glycosphingolipid content of human pk and p erythrocytes, 3263 Proline and glycine uptake by renal brushbordermembrane vesicles, Glomerularfiltration 4521 Distribution of anionic sites in glomerular basement membranes: Role in Glycinereductase filtration and attachment, 1646 Chemicalcharacterization of selenoproteincomponent of clostridial Solute and water movement in kidney, 252 glycinereductase: Selenocysteine is the organoseleniummoiety, 2659 Glucagon Glycogen Binding of insulin to isolated nuclei, 1427 Hepaticglycogen synthesis stimulatedby amino acids, 3433 Hormonal control of pyruvate kinase activity and of gluconeogenesis in Glycolipid isolated hepatocytes, 2762 Long-chainneutral glycolipids and gangliosidesof murinefibroblast Hormonal stimulation of DNA synthesis in primary cultures of adult rat lines and their low- and high-tumorigenichybrids, 1568 hepatocytes, 3589 Glycolysis,oscillating Hypertrophy and hyperplasia of somatostatin-containing D-cells in Controlof oscillatingglycolysis of yeast by stochasticperiodic, and diabetes, 1338 steady sourceof substrate:A model and experimentalstudy Induction and decay of glucagon-induced amino acid transport in (correction),661 primary cultures of adult rat liver cells: Paradoxical effects of Glycoprotein cycloheximide and puromycin, 4511 Alterationsin surfaceglycoproteins and level of sialyltransferaseof cells Kinetics of glucagon in man: Effects of starvation, 1735 transformedby temperature-sensitivemutant of simian virus 40, 4090 Model for hormone-activated adenylate cyclase systems, 1189 Asynchronoussynthesis of erythrocytemembrane proteins, 3206 Glucocerebrosidase (EC 3.2.1.45) Biosynthesisof lipid-linkedoligosaccharides and glycoproteinin aorta: Enzyme replacement therapy in Gaucher's disease: Purification of Stimulationby acceptorlipids isolated from liver, 2574 glucocerebrosidase, 4672 Changesin cellularglycoproteins after transformation:Identification of Gluconeogenesis specificglycoproteins and antigensin sodium dodecylsulfate gels, 4457 Hepatic glycogen synthesis stimulated by amino acids, 3433 Detergent-solubleHLA antigenscontain hydrophilicregion at the Hormonal control of pyruvate kinase activity and of gluconeogenesis in COOH-terminusand penultimatehydrophobic region, 2481 isolated hepatocytes, 2762 Fetal proteinin chromatinof Novikoffhepatoma and Walker256 Kinetics of glucagon in man: Effects of starvation, 1735 carcinosarcomatumors that is absent from normaland regenerating Zn2+ as inhibitor and activator of fructose 1,6-bisphosphatase of rat rat liver, 3258 liver, 2692 Hepaticreceptor of avian origincapable of bindingspecifically modified Glucose glycoproteins,341 see also Sugar Humanalpha-fetoprotein as modulatorof humanlymphocyte Choleragen-mediated release of trapped glucose from liposomes transformation:Correlation of biologicalpotency with electrophoretic containing ganglioside GM1,3480 variants,4645 Growth of human diploid fibroblasts in absence of glucose utilization, Interferon:Purification and initial characterizationfrom humandiploid 4110 cells, 520 Hormonal control of pyruvate kinase activity and of gluconeogenesis in Papain cleavagesite of H-2 glycoproteins,915 isolated hepatocytes, 2762 Partial purificationof serumfactor that causes necrosisof tumors,381 Kinetics of glucagon in man: Effects of starvation, 1735 Specific recognitionsites mediatingclearance of lysosomalenzymes in Paradoxical effects of cycloheximide and cytochalasin B on hamster cell vivo, 4045 hexose uptake, 2429 Structural(shape-maintaining) role of cell surfaceglycoprotein of Reconstitution of D-glucose transport catalyzed by protein fraction from Halobacteriumsalinarium, 2687 human erythrocytes in sonicated liposomes, 396 Structureof HLA antigens:Amino-acid and carbohydratecompositions Glucose, deoxy- and NH2-terminalsequences of four antigenpreparations, 910 Metabolic mapping f : ii'i .!' \ i-:.,ml system of monkey by Glycoproteinprecursor autoradiographic 'l 'j(! .x'.:;: l ,'?.-^ technique, 4230 Fucose-deficientglycoprotein precursor to Rauscherleukemia virus Glucose intolerance gp69/71,2326 Diabetogenic peptide from human growth hormone: Partial purification Glycosaminoglycan from peptic digest and long-term action in ob/ob mice, 4706 Mucopolysaccharidoses(A Review),630 Glucose-6-phosphate Mucopolysaccharidoses(A Review)(correction), 2165 Glycosylation of hemoglobin in vitro: Affinity labeling of hemoglobin by Glycosphingolipid glucose-6-phosphate, 3534 Alterationsin cell surfaceglycosphingolipids and other lipid classes of Glucose-6-phosphatedehydrogenase (EC 1.1.1.49) fibroblastsin familialhypercholesterolemia, 4339 Modifications of purified glucose-6-phosphate dehydrogenase and other Glycosphingolipidcontent of humanpk and p erythrocytes,3263 enzymes by a factor of low molecular weight abundant in some Goldfish leukemic cells, 77 see Carassiusauratus Regulation of induction of T and B cell colonies in vitro by normal Golgi complex human lymphocytes, 4546 Cell surfacereceptors for melanotropinassociated with Golgiregion in ca-Glucosyltransferase mouse melanomacells, 559 see Dextrin dextranase Endoplasmicreticulum: A cytochemist'sview (A Review),2781 see Dextrin dextranase Gonadotropin ,B-Glucuronidase (EC 3.2.1.31) Circadian organization of estrous cycle of golden hamster, 2923 Specific recognition sites mediating clearance of lysosomal enzymes in Gonochore vivo, 4045 Sex ratio, sex change, and natural selection, 3656 Glutamine Gossypium barbadense Growth of human diploid fibroblasts in absence of glucose utilization, Nuclear DNA replication in radicles of germinating cotton, 3220 4110 Granuloma Hepatic glycogen synthesis stimulated by amino acids, 3433 Elevated angiotensin converting enzyme in lymph nodes containing Renal CO2 production from glutamine and lactate as function of arterial non-necrotizing granulomas in sarcoidosis, 2137 perfusion pressure in dog, 4235 Grayanotoxin Glutamine synthetase (EC 6.3.1.2) Pharmacologic characterization of Na+ ionophores in L6 myotubes, 1355 Glutamine svnthetaqe from Escherichia coli: Kinetic evidence for two Growth,anaerobic reaction ::l.lr:ml?(:,' a(- in biosynthetic reaction, 476 Anaerobic growth of a Rhodopseudomonoas species in dark with carbon Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4745

monoxideas sole carbonand energysubstrate, 3298 Stringentfactor from Escherichiacoli directs ribosomalbinding and Growth,bacterial releaseof unchargedtRNA, 0707 Helicalgrowth of Bacillus subtilis: Model of cell growth,1740 Guanosine5'- (,,y-imino)triphosphate Growth,clonal Desensitizationof (-adrenergicreceptors by f-adrenergicagonists in Selenium:Essential trace nutrientfor growthof WI-38diploid human cell-freesystem: Resensitization by guanosine fibroblasts,2023 5'-(3,^y-imino)triphosphateand other purinenucleotides, 1494 Growthcontrol Guanosine,7-methyl- Activity of yeast extractsin cell-freestimulation of DNA replication, BacteriophageT3 and T7 early RNAs are translatedby eukaryotic80S 3933 ribosomes:Active phageT3 coded S-adenosylmethioninecleaving Cell surfaceprotein partially restores morphology, adhesiveness, and enzymeis synthesized,2752 contact inhibitionof movementto transformedfibroblasts, 1217 Differentialsynthesis of blockedand unblocked5'-termini in reovirus Hormoneresponsive human breast cancerin long-termtissue culture: mRNA:Effect of pyrophosphateand pyrophosphatase,3448 Effect of insulin,4536 Guanosine-5'-monophosphate,7-methyl- Mutantsof Balb/c 3T3 fibroblastsdefective in adhesivenessto Inhibitionof initiationof proteinsynthesis by substratum:Alteration in cell surfaceproteins, 544 7-methylguanosine-5'-monophosphate,19 Polypeptideof 18,000molecular weight inducesearly events and Guanosinenucleotides stimulatesDNA synthesis in culturedcells, 4555 Model for hormone-activatedadenylate cyclase systems, 1189 Growthcurve, computer-derived Regulationof ornithinedecarboxylase activity by guaninenucleotides: In Solid tumor models for assessmentof differenttreatment modalities: vivo test in potassium-depletedEscherichia coli, 3502 Systematicsof responseto radiotherapyand chemotherapy,818 Guanosinetriphosphatase,elongation factor G dependent Growthfactor Role of 5S RNA in assemblyand functionof 50S subunit from see also Epidermalgrowth factor; Fibroblast-derived growth factor; Escherichiacoli, 2221 Nerve growthfactor Guanosine5'-triphosphatase, ribosome-dependent Polypeptideswith nonsuppressibleinsulin-like and cell-growth Ribosome-dependentGTPase from yeast distinct from elongationfactor promotingactivities in humanserum: Isolation, chemical 2, 73 characterization,and biologicalproperties of forms I and II, 2365 Guanosine5'-triphosphate 3'-diphosphate Growthfactor, insulin-like Ribosomalproteins of Escherichiacoli that stimulate Amino-terminalsequences of two polypeptidesfrom humanserum with stringent-factor-mediatedpyrophosphoryl transfer in vitro, 1839 nonsuppressibleinsulin-like and cell-growth-promotingactivities: Stringentfactor fromEscherichia coli directs ribosomalbinding and Structuralhomology with insulinB chain, 4379 releaseof unchargedtRNA, 0707 Growthhormone Guanylatecyclase (EC 4.6.1.2) see Somatotropin Ca2+and adenylateand guanylatecyclases in controlof platelet Growthhormone release inhibitory factor secretionand aggregation,1829 see Somatostatin Cyclicnucleotide metabolism in compensatoryrenal hypertrophyand Growthinhibition neonatalkidney growth,524 Growthdelay inducedin Escherichiacoli by near ultravioletradiation, Regulationof guanylateand adenylatecyclase activities by lysolecithin, 59 1586 Growthkinetics Guanylyl-imidodiphosphate Insulin effect on cell cycle:Kinetics of growthparameters in confluent Intraneuronalguanylyl-imidodiphosphate injection mimics long-term chick cells, 3173 synaptichyperpolarization in Aplysia, 4689 Growth,lytic Guineapig DNA-bindingprotein with characteristicsexpected for Cro proteinof Force-velocitycharacteristics for calcium-activatedmammalian bacteriophageX, a repressoressential for lytic growth,2249 slow-twitchand fast-twitchskeletal fibers from the guinea pig, 4693 Growthregulation L-Gulonolactoneoxidase (EC 1.1.3.8) Alterationsin surfaceglycoproteins and level of sialyltransferaseof cells Gene for L-gulono-y-lactoneoxidase is not expressedin animalssubject transformedby temperature-sensitivemutant of simian virus 40, 4090 to scurvy:Immunologic evidence, 2066 Controlof cell division in Saccharomycescerevisiae by methionyl-tRNA, Gynandromorph 1664 Courtshipin Drosophilamosaics: Sex-specific foci for sequentialaction Diadenosine5',5`'-P1,P,4-tetraphosphate (Ap4A) in mammaliancells in patterns,4154 levels varyingwidely with proliferativeactivity of tissue: Possible positive "pleiotypicactivator", 3984 Initiationof replicationin chromosomalDNA inducedby extracts from Hagemanfactor proliferatingcells, 2231 see Coagulationfactor XII Mutualpotentiation by magnesiumand calciumof growthin animal Halobacteriumsalinarium cells, 168 Structural(shape-maintaining) role of cell surfaceglycoprotein of Temperature-sensitivechanges in surfacemodulating assemblies of Halobacteriumsalinarium, 2687 fibroblaststransformed by mutants of Rous sarcomavirus, 2047 Halogenhalogenide Growthresponse Anglesbetween orthogonal spd bond orbitalswith maximumstrength, Responsesof Phycomycesindicating optical excitationof lowest triplet 1403 state of riboflavin,1969 Halothane Guanosine3':5'-cyclic mononucleotide in animalcells Nuclearmagnetic resonance studies of interactionof generalanesthetics 3':5'-CyclicGMP-dependent protein kinase: Purification and with 1,2-dihexadecyl-sn-glycero-3-phosphorylcholinebilayer, 3999 characterization,3918 Hamster Guanosine3':5'-cyclic monophosphate see Mesocricetusauratus see also Cyclicnucleotide metabolism Hapten binding Crossinhibitory interactions of potential mediatorsof hormoneand Kinetic evidencefor hapten-inducedconformational transition in neurotransmitteraction, 2982 immunoglobulinMOPC 460, 3549 Guanosine3':5'-cyclic monophosphate binding protein Hapten mobility Guanosine3':5'-cyclic monophosphate binding proteins in rat tissues, Model membranes:Lateral hapten mobilityand immunochemistry,2977 2559 Harmonicfunction Guanosine3':5'-cyclic monophosphate in animalcells Maximalfunctions: Poisson integralson symmetricspaces, 2547 Ca2+and adenylateand guanylatecyclases in controlof platelet Hearing secretionand aggregation,1829 Caecilianear, 3744 Catecholamine-stimulatedcyclic GMP accumulationin rat pineal: Ear and hearingin Sphenodonpunctatus, 4244 Apparentpresynaptic site of action, 3398 Heavy meromyosin Cellularcyclic nucleotidesand enzymesecretion in pancreaticacinar cell, Myosin-paramyosincofilaments: Enzymatic interactions with F-actin, 156 3015 Cyclicnucleotide metabolism in compensatoryrenal hypertrophyand Heavy metal staining neonatalkidney growth, 524 Platinumbinds selectivelyto phosphorothioategroups in mono- and Distributionof 3':5'-cyclicAMP and 3':5'-cyclicGMP in rabbit retina in polynucleotides:General method for heavy metal stainingof specific vivo:Effects of dark and light adaptationand ischemia,4442 nucleotides,2536 Intraneuronalguanylyl-imidodiphosphate injection mimics long-term Heidenhainpouch synaptichyperpolarization in Aplysia, 4689 Preventionand suppressionby azathioprineof venom-induced Guanosine3':5'-cyclic monophosphate in culturedanimal cells protein-losinggastropathy in dogs, 968 Effects of concanavalinA and succinylatedderivative on lymphocyte Helix-coil transition proliferationand cyclic nucleotidelevels, 1717 Ethidiumbromide.(dC-dG-dC-dG)2 complex in solution:Intercalation Hormoneand neurotransmitterreceptors in establishedvascular and sequencespecificity of drug bindingat tetranucleotideduplex endothelialcell line, 1612 level, 3343 Guanosine3':5'-cyclic monophosphate in microorganisms Nuclearmagnetic resonance studies of helix-coil transitionof 3':5'-CyclicGMP derivatives:Effect on formationof Caulobactersurface poly(dA-dT)in aqueoussolution, 674 structures,3303 Helminthosporiumsacchari Inhibitionand stimulationof developmentof bioluminescentsystem in Serinol as an activatorof toxin productionin attenuatedcultures of Beneckeaharveyi by cyclic GMP, 4454 Helminthosporiumsacchari, 4007 Guanosine-5'-diphosphate-3'-diphosphate Hemagglutinin,amino-terminal sequence DNA dependentsynthesis of proteinL12 from Escherichiacoli Chromatographicisolation of hemagglutininpolypeptides from influenza ribosomes,in vitro, 3156 virus vaccine and determinationof amino-terminalsequences, 238 Ribosomalproteins of Escherichiacoli that stimulate Hemagglutininpolypeptide stringent-factor-mediatedpyrophosphoryl transfer in vitro, 1839 Chromatographicisolation of hemagglutininpolypeptides from influenza Downloaded by guest on October 5, 2021 4746 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

virus vaccine and determination of amino-terminal sequences, 238 synthase in liver, 1499 Hematoside Magnetic circular dichroism of ferrous carbonyl adducts of cytochromes Long-chain neutral glycolipids and gangliosides of murine fibroblast P-450 and P-420 and their synthetic models: Mercaptide as fifth lines and their low- and high-tumorigenic hybrids, 1568 ligand to iron, 6 Heme Hemostasis Carbon monoxide binding to pentacoordinate mercaptide-heme Antagonism of 5-hydroxykynurenamine against serotonin action on complexes: Kinetic study on models for cytochrome P-450, 3338 platelet aggregation, 643 Mechanism of delayed inhibition of protein synthesis in heme-deficient Multiple active forms of thrombin: Binding to platelets and effects on rabbit reticulllocytelysates, 3506 platelet function, 1660 Nature of () and (CO()binding to metalloporphyrins and heme proteins, Heparitensulfate lyase (EC 4.2.2.8) 3333 Sulfated proteoglycans synthesized in nonchondrogenic cells, Protein synthesis in reticulocyte lysates: Phosphorylation of presumptive chondroblasts, and chondroblasts, 3224 mnethioivlI-tRNA, binding factor by protein kinase activity of Hepatitis B It(-ll?l.al,i((l;I i'libiltoi isolated from heme-deficient lysates, 3112 Hepatitis B vaccine trial, study design, 955 Selenium regulation of hepatic heme metabolism: Induction of Hepatocyte 6-aminolevulinate synthase and heme oxygenase, 4428 Hepatic glycogen synthesis stimulated by amino acids, 3433 Heme-deficiency inhibitor Hormonal control of pyruvate kinase activity and of gluconeogenesis in Protein synthesis in rabbit reticulocyte lysates: Inhibition of protein isolated hepatocytes, 2762 synthesis by translational inhibitor from heme-deficient lysates and Hormonal stimulation of DNA synthesis in primary cultures of adult rat relationship to initiation factor that binds Met-tRNAf, 2720 hepatocytes, 3589 Heme oxygenase (decyclizing) (EC 1.14.99.3) Sex differences in binding of human growth hormone to isolated rat Cobalt inhibition of synthesis and induction of 1-aminolevulinate hepatocytes, 847 synthase in liver, 1499 Hepatoma Selenium regulation of hepatic heme metabolism: Induction of Hummanalpha-fetoprotein as modulator of human lymphocyte (5-aminolevulinate synthase and heme oxygenase, 4428 1iiiioi';,Ol i(,ln:Correlation of biological potency with electrophoretic Heme-regulated translational inhibitor variants, 4645 Regulation of protein synthesis in rabbit reticulocyte lysates: Herbicide residue Purification and initial characterization of cyclic 3':5'-AMP Screening by negative chemical ionization mass spectrometry for independent protein kinase of heme-regulated translational inhibitor, environmental contamination with toxic residues: Application to 4349 human urines, 1777 Hemerythrin Heritable disease Structure of iron complex in methemerythrin, 349 Simultaneous synthesis of types I and III collagen by fibroblasts in Hemin culture, 4037 Protein kinase activity associated with hemin-controlled repressor of Hermaphrodite, sequential rabbit reticulocyte, 3078 Sex ratio, sex change, and natural selection, 3656 Hemin regulation Herpes simplex virus Protein synthesis in reticulocyte lysates: Effects of 3:5'-cyclic AMP, Endogenous mouse type C virus activated by ultraviolet-irradiated ATP, and GTP on inhibitions induced by heme-deficiency, herpes simplex virus types 1 and 2, 646 double-stranded RNA, and a reticulocyte translational inhibitor, 1112 Herpesvirus Hemoglobin Single-stranded complementary ends appear in vivo on parental see also Deoxyhemoglobin; Leghemoglobin; Methemrnof!ob;r herpesvirus DNA, 2674 Glycosylation of hemoglobin in vitro: Affinil l.imeli,:. . : Im.'moglobinby Heterokaryon glucose-6-phosphate, 3534 Homozygous mutants isolated after induced self-fertilization in Nature of 02 and CO binding to metalloporphyrins and heme proteins, Tetrahymena, 3243 3333 Heterozygosity Radiation-induced mutations at mouse hemoglobin loci, 2843 Infinite allele model with varying mutation rate, 4164 Rate , 0l,-i1ern-'r.v r':rcture change in hemoglobin measured by Heterozygosity, double -:: !.. .I . !-.,-x I ..l,I -:;, 4497 Porphyria variegata and porphyria cutanea tarda in siblings: Chemical Sherpas living permanently at high altitude: Pattern of adaptation, 747 and genetic aspects (Addendum), 1323 Soluble dextran-hemoglobin complex: Potential blood substitute, 2128 Hexamethylene-tetraselenafulvalinium Structure-function relations in hemoglobin as determined by x-ray Conductivity and structure of bilinear organic addition compounds, 3820 absorption spectroscopy, 491 Hexosamine biosynthetic pathway Subunit interfaces: Role in allosteric mechanism of hemoglobin, 3793 Chitin biosynthesis during Blastocladiella zoospore germination: Hemoglobin alpha chain Hexosamine biosynthetic pathway is post-translationally activated Hemoglobin Wayne: Frameshift mutation detected in human during cell differentiation, 534 hemoglobin alpha chains, 882 Hexosaminidase Hemoglobin, fetal see 3-N-Acetylglucosaminidase Fetal hemoglobin synthesis stimulated in bone marrow cultures from Hexose uptake adult individuals, 2033 Paradoxical effects of cycloheximide and cytochalasin B on hamster cell Hemoglobin G Philadelphia hexose uptake, 2429 Trimodality in proportion of hemoglobin G Philadelphia in High blood pressure heterozygotes: Heterogeneity in number of human alpha chain loci, see Hypertension 3633 High dimensional cohomology Hemoglobin H disease High dimensional cohomology of discrete groups, 1795 Trimodality in proportion of hemoglobin G Philadelphia in High pressure heterozygotes: Heterogeneity in number of human alpha chain loci, Erythrocyte phosphate transport inhibited by high pressures, 2767 3633 Hirudo medicinalis Hemoglobin M Milwaukee Oscillatory neuronal circuit generating locomotory rhythm, 3734 Nuclear magnetic resonance stuldy of heme-heme interaction in Histamine hemoglobin M Milwaukee: \Ilcll(-(li: li of cooperative ligand binding in Prostaglandin E synthesis in cultured human umbilical vein smooth normal hemoglobin, 1581 muscle cells, 1617 Hemoglobinopathy Histidine binding protein J Fetal hemoglobin synthesis stimulated in bone marrow cultures from Protein-protein interaction in transport: Periplasmic histidine-binding adult individuals, 2033 protein J interacts with P protein' 1877 Hemoglobin oxidation Bohr effect Histidine, 3-phospho- Linearity of hemoglobin oxidation Bohr effect, 800 3-P!^-.>h-!i=t]m'ni. isolated from phosphorylated pyruvate, phosphate Hemoglobin S Dichloromethane as antisickling agent in sickle cell hemoglobin, 4195 Histochemical stain Inhibition of erythrocyte sickling by cystamine, a thiol reagent, 3288 Expression of human and suppression of mouse nucleolus organizer Polvmeri7.at-r. of deoxygenated sickle cell hemoglobin: Thermodynamic activity in mouse-human somatic cell hybrids, 4531 * ;I;!-;., .':" i Histocompatibility antigen Supersaturation in sickle cell hemoglobin solutions, 3035 see Antigen, histocompatibility Hemoglobin subunit Histocompatibility complex Spectral differences between a and 3 heme groups within human Determinants of antigenic molecules responsible for genetically deoxyhemoglobin, 1140 controlled regulation of immune responses, 2862 Hemoglobin synthesis Histone Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in Activation of chromatin by acetylation of histone side chains, 3937 tissue cultures of rat erythroleukemia cells transformed by Covalent modification of proteins by metabolites of NAD+, 3131 7,12-dirnmeth,lhbon?7t.nthracooe. 1237 Histones H3 and H4 interact with the ends of nucleosome DNA, 4400 Potent mI','..-. .. li':,?.?' , i '.iii! i n murine erythroleukemia cells, 862 Subunit organization in chicken erythrocyte chromatin, 505 Hemoglobin Wayne Synthesis of nuclear proteins during DNA repair synthesis in human Hemoglobin Wayne: Frameshift mutation detected in human diploid fibroblasts damaged with ultraviolet radiation or hemoglobin alpha chains, 882 N-acetoxy-2-acetylaminofluorene, 1466 Hemolysis Yeast histones: Synthesis in cell cycle, 1863 Polyclonal activation of bone-marrow-derived lymphocytes from human Histone acetylation peripheral blood measured by direct plaque-forming cell assay, 3676 Deficiency in histone acetylation in nontransforming host range mutants Hemoprotein of polyoma virus, 1092 Cobalt inhibition of synthesis and induction of 1-aminolevulinate Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4747

Histone-likeprotein betweentsAF8 hamsterand humancells, 2052 Cyanobacterial DNA-binding protein related to Escherichia coli HU, Hybridcell, human X mouse 1917 Expressionof humanand suppressionof mouse nucleolusorganizer Histone synthesis activity in mouse-humansomatic cell hybrids,4531 Deposition of histone onto replicating chromosome: Newly synthesized Heteropolymerichexosaminidase A in human X mouse hybridcells, 3637 histone is not found near replication fork, 2266 Locus requiredfor flavoprotein-linkedmonooxygenase expression Hodgkin'sdisease assignedto humanchromosome 2, 4628 Simultaneous detection of reverse transcriptase and high molecular Loss of mouse chromosomesin somaticcell hybridsbetween HT-1080 weight RNA in tissue of patients with Hodgkin's disease and in human humanfibrosarcoma cells and mouse peritonealmacrophages, 3248 patients with leukemia, 4649 Two linked humangenes cotransferred into culturedmouse cells, 1274 Homocyst(e)ine Hybridcell, mouse X mouse In vivo rates of methionine biosynthesis in transformed human and Long-chainneutral glycolipids and gangliosidesof murinefibroblast malignant rat cells auxotrophic for methionine, 1523 lines and their low- and high-tumorigenichybrids, 1568 Homogeneouscurves Hybridcell, neuroblastomaX glioma Maximal functions: Homogeneous curves, 2176 Specificityof synapse formation,3544 Homomorphism Synapseformation between clonal neuroblastomaX gliomahybrid cells Relativized problems with abelian phase group in topological dynamics, and striated muscle cells, 123 1007 Toleranceand dependenceevoked by endogenousopiate peptide, 3165 Homozygousfamilial hypercholesterolemia Hybridization,molecular see also Familial hypercholesterolemia see Molecularhybridization Binding, internalization, and degradation of low density lipoprotein by Hybridization,nucleic acid normal human fibroblasts and by fibroblasts from homozygous familial Anticomplementarynature of smallerDNA producedduring synthesis of hypercholesterolemia, 14 extensiveDNA copies of poliovirusRNA, 3408 Degradation of cationized low density lipoprotein and regulation of Autoregulationof simian virus 40 gene A by T antigen,3083 cholesterol metabolism in homozygous familial hypercholesterolemia Geneticallytransmitted retravirus isolated from Mus cervicolor,3579 fibroblasts, 3178 Identificationof recombinantsof phage X,3394 Low density lipoprotein receptors localized on plasma membrane of Nucleotidesequences in mouse DNA and RNA specific for Moloney normal human fibroblasts and their absence in cells from familial sarcomavirus, 3705 hypercholesterolemia homozygote, 2434 Hybridization,ribonucleic acid.deoxyribonucleic acid Hormone Adenovirusmessenger RNA mappedby electronmicroscopy, 2069 see also Isohormones; Prohormone; Protein hormone; Receptor, DNA copies of poliovirusRNA synthesizedin high yields and at high hormone; Steroid hormone; specific hormones specific activities, 2191 Binding of insulin to isolated nuclei, 1427 Hybridizationof potato spindle tuber viroid to cellularDNA of normal Cross inhibitory interactions of potential mediators of hormone and plants, 2453 neurotransmitter action, 2982 Hybridizationof RNA to double-strandedDNA: Formationof R-loops, Cultured tumor cells: Affinity isolation by drugs and hormones 2294 covalently bound to glass and Sepharose beads, 2013 Mappingof in vivo messengerRNAs for bacteriophage4X174, 3519 Maturation (meiosis) in small Xr,nop:rs laovis oocytes induced by Mappingof in vivo messengerRNAs for bacteriophage4X174 injection of maturation pthri,Iiil i' !;,M, ,'r.2028 (correction),4247 Synthesis and activities of neurotensin, and its acid and amide analogs: Mappingof three species of polyomamRNA, 1480 Possible natural occurrence of [Gln4]-neurotensin, 3833 Messengerspecifying sequences in DNA of chromatinsubunits, 1572 Hormoneaction RNA-dependentDNA polymerase,different from knownviral reverse Hormone responsive human breast cancer in long-term tissue culture: transcriptases,in chickensystem, 3025 Effect of insulin, 4536 Sequencesrelated to immunoglobulinkappa chain messengerRNA in T Third amino acid residue of oxytocin is important for action on isolated cells, 2467 rat uterus: Relationship between hormone conformation and activity, Somaticrearrangement of immunoglobulingenes codingfor variableand 3054 constant regions,3628 Hormone,activation by Tandem integrationof avian myeloblastosisvirus DNA with endogenous Model for hormone-activated adenylate cyclase systems, 1189 provirusin leukemicchicken cells, 1749 Hormone,gastrointestinal Transcriptionin vitro of chromatinin presenceof mercurated Vasoactive intestinal polypeptide localized to central and peripheral nucleotide,1564 neurons, 3197 Viraltranscription and tumor antigen expressionregulated in cells Hormone,glycoprotein transformedby simian virus 40, 1931 Cholera toxin interactions with thyrotropin receptors on thyroid plasma Hybridnuclease (EC 3.1.4.34) membranes, 1679 Assay of ribonucleaseH, endoribonucleases,and phosphatases,1556 Relationship of gangliosides to structure and function of thyrotropin Assay of ribonucleaseH, endoribonucleases,and phosphatases receptors: Their absence on plasma membranes of thyroid tumor (correction),4711 defective in thyrotropin receptor activity, 4060 RibonucleaseH of calf thymus:Substrate specificity, activation, Hormonemechanism inhibition,1087 Thyrotropin-ganglioside interactions and relationship to structure and Hydrocarbon function of thyrotropin receptors, 842 Equationof state describinghydrophobic interactions, 2955 Hormoneprecursor Hydrocarbon,aromatic mRNA-dependent synthesis of authentic precursor to human placental Metabolicactivation of aromatichydrocarbons in purifiedrat liver lactogen: Conversion to mature hormone form in ascites cell-free nuclei:Induction of enzymeactivities and bindingto DNA with and extracts, 1179 without monooxygenase-catalyzedformation of active oxygen,457 Hormone,sex Hydrocarbonchain Control of renal vitamin D hydroxylases in birds by sex hormones, 2701 Innerand outer hydrocarbonchains of lipid bilayervesicles: Direct Hormonestimulation spectroscopicobservation, 2716 Adenylate cyclase activity in LM cells by modified manipulation of Hydrocarbon,polycyclic membrane phospholipid composition in vivo, 4482 Aryl 4-monooxygenaseand cytochromeP-450 in aorta:Role in Hormoneturnover atherosclerosis,3723 Kinetics of glucagon in man: Effects of starvation, 1735 Hydrocarbon,polycyclic, carcinogenic Host restriction Mutabilityof differentgenetic loci in mammaliancells by metabolically Host restriction of Friend leukemia virus: Synthesis and integration of activatedcarcinogenic polycyclic hydrocarbons, 188 provirus, 2356 Mutagenicmetabolites of benzo[a]pyreneidentified in mammaliancells, House monotoneapportionment 607 House monotone apportionment schemes, 684 Structureof 7,12-dimethylbenz[a]anthracene-guanosineadducts, 2311 Humanpapilloma virus Hydrocarbonreaction Human papilloma virus DNA: Physical mapping and genetic Metal cluster in catalysis:Hydrocarbon reactions, 4274 heterogeneity, 1310 Hydrogenbonding Humoralresponse Crystalstructure of complexbetween lumiflavin and Antigen stimulation of prostaglandin synthesis and control of immune 2,6-diamino-9-ethylpurine:Flavin adeninedinucleotide model responses, 1300 exhibitingcharge-transfer interactions, 3807 Hyaluronidase Sequence-specificrecognition of double helical nucleic acids by proteins, see Hyaluronoglucosaminidase 804 Hyaluronoglucosaminidase(EC 3.2.1.35) Hydrogenevolution Differential labeling of cell surface of single ciliary ganglion neurons in Hydrogen evolution affects efficiency of nitrogen fixation in nodulated vitro, 4100 symbionts, 1207 Hybridcell, cat X mouse Separation of hydrogenase-catalyzed hydrogen-evolution system from Bvr-1, a restriction locus of a type-C RNA virus in feline cellular electron-donating system by enzymic electric cell technique, 2947 genome: Identification, location, and phenotypic characterization in Hydrogenproduction cat x mouse somatic cell hybrids, 4618 Anaerobic growth of a Rhodopseudomonoas species in dark with carbon Hybrid cell, hamster X human monoxide as sole carbon and energy substrate, 3298 AK1:Np:ABO linkage group assigned to human chromosome 9, 895 Hydrolysis Genetics of somatic mammalian cells: Genetic, immunologic, and Hydrolysis and transpeptidation of peptide substrates by acetyl-pepsin, biochemical analysis with Chinese hamster cell hybrids containing 3915 selected human chromosomes, 193 Hydrophobicinteraction Human chromosome 3 releases block at G1 of cell cycle, in hybrids Equation of state describing hydrophobic interactions, 2955 Downloaded by guest on October 5, 2021 4748 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Hydrophobicity Immune recognition Binding of Triton X-100 to diphtheria toxin, crossreacting material 45, Phylogenetic origins of immune recognition: Lymphocyte surface and their fragments, 4449 immunoglobulins in goldfish, Carassius auratus, 2476 Hydroxyapatite Immune response y-Carboxyglutamic acid-containing protein from bone, 1447 Antigen stimulation of prostaglandin synthesis and control of immune 25-Hydroxycholecalciferol responses, 1300 Control of renal vitamin D hydroxylases in birds by sex hormones, 2701 Antigen stimulation of prostaglandin synthesis and control of immune 25-Hydroxycholecalciferol 1-monooxygenase (EC 1.14.13.13) responses (correction), 2527 Control of renal vitamin D hydroxylases in birds by sex hormones, 2701 Determinants of antigenic molecules responsible for genetically 5-Hydroxykynurenamine controlled regulation of immune responses, 2862 Antagonism of 5-hydroxykynurenamine against serotonin action on Immune response modulated by synthetic adjuvant and analogs, 2472 platelet aggregation, 643 Immunogenicity: Immunon model of immune response, 3671 Hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) Immunogenicity: Immunon model of immune response (correction), 4247 Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity Immunochemistry and cholesterol synthesis in nonhepatic tissues of rat, 2564 Model membranes: Lateral hapten mobility and immunochemistry, 2977 Regulation of 3-hydroxy-3-methylglultaryl coenzyme A reductase in Immunocytochemistry hepatoma cells grown in vivo and in vitro, 2735 Intracellular site of synthesis and localization of leghemoglobin in root Hydroxyproline nodules, 3843 --Carboxvglutamic acid-containing protein from bovine bone: Primary Immunodeficiency structure, 3374 Purine metabolism in adenosine deaminase deficiency, 2867 15-Hydroxyprostaglandin dehydrogenase Immunodiffusion 15-Hydroxyprostaglandin dehydrogenase specific for prostaglandin A in eS-Adrenergicregulation of secretion of mouse saliva rich in nerve growth rabbit kidney, 1107 factor, 4210 15-Hydroxyprostaglandin dehydrogenase specific for prostaglandin A in Immunologic and fine structure evidence of avidly bound host serum rabbit kidney (correction), 2528 proteins in surface coat of bloodstream trypanosome, 1222 Hylobates lar Immunoelectrophoresis Antigens and antibodies crossreactive with type C viruses of woolly Immunologic and fine structure evidence of avidly bound host serum monkey and gibbon ape in animal models and in humans, 1725 proteins in surface coat of bloodstream trypanosome, 1222 Hyperlipidemia Immunofluorescence Alterations in cell surface glycosphingolipids and other lipid classes of Antisera against electrophoretically purified tubulin stimulate fibroblasts in familial hypercholesterolemia, 4339 colchicine-binding activity, 1246 Hypersensitivity, delayed-type Chromosomal proteins: Locations in polytene chromosomes, 2038 Role of major histocompatibility complex gene products in delayed-type Cytoplasmic microtubules in tissue culture cells appear to grow from hypersensitivity, 2486 organizing structure towards plasma membrane, 867 Hypertension Determination of in situ distribution of chromosomal proteins, 423 Effect of main artery occlusion of one kidney on blood pressure of dogs, Hypertrophy and hyperplasia of somatostatin-containing D-cells in 1722 diabetes, 1338 High blood pressure related to carcinogen-induced unscheduled DNA Immunological characterization of subunit of 100 A filaments from synthesis, DNA carcinogen binding, and chromosomal aberrations in muscle cells, 4344 human lymphocytes, 2496 Microfilament organization and surface topography: Changes upon 15-Hydroxyprostaglandin dehydrogenase specific for prostaglandin A in transformation of chick embryo fibroblasts with Rous sarcoma virus, rabbit kidney, 1107 4065 Hypervariable region Neurofilament protein localized in neuroblastoma cells by Human and murine phosphorylcholine-binding immunoglobulins: immunofluorescent staining, 3192 Conserved subgroup and first hypervariable region of heavy chains, Organization and energy-dependent growth of microtubules in cells, 2798 2096 Phylogenetic origins of immune recognition: Lymphocyte surface Size differences among immunoglobulin heavy chains from immunoglobulins in goldfish, Carassius auratus, 2476 phosphorylcholine-binding proteins, 2109 Vitamin A-containing lipocytes and formation of type III collagen in Hypolipidemic drug liver injury, 3719 Fatty acyl-CoA oxidizing system in rat liver peroxisomes: Enhancement Immunogenetics by clofibrate, a hypolipidemic drug, 2043 Determinants of antigenic molecules responsible for genetically Hypophosphatemia controlled regulation of immune responses, 2862 Hypophosphatemia: Mouse model for human familial hypophosphatemic Immunogenicity (vitamin D-resistant) rickets, 4667 Immunogenicity: Immunon model of immune response, 3671 Hypophysis Immunogenicity: Immunon model of immune response (correction), 4247 Obligatory role of hypophysis in sexual differentiation of hepatic Isoimmunization against human chorionic gonadotropin with conjugates metabolism in rats, 1462 of processed 3-subunit of hormone and tetanus toxoid, 218 Hypothalamic damage Immunoglobulin Bandage-backfall reaction: Occurs in infancy, hypothalamic damage, and Antibody differentiation: Apparent sequence identity between variable catalepsy, 3311 regions shared by IgA and IgG immunoglobulins, 923 Hypothalamic factor Measles virus-specific IgD antibodies in patients with subacute Pro-Leu-Gly-NH2 conformation, 1203 sclerosing panencephalitis, 1297 Somatostatin conformation: Stable intramolecular structure by circular Ontogeny of lymphocyte subpopulations in human fetal liver, 919 dichroism, diffusion, and sedimentation equilibrium, 1199 Immunoglobulin allotype Hypothalamus Genetic polymorphism of IgD-like cell surface immunoglobulin in mouse, Morphinomimetic activity of synthetic fragments of (-lipotropin and 1305 analogs, 3308 Immunoglobulin allotypes of rabbit kappa chains: Polymorphism of Synthesis and activities of neurotensin, and its acid and amide analogs: control mechanism regulating closely linked duplicated genes? 1293 Possible natural occurrence of [Gln4]-neurotensin, 3833 Immunoglobulin, heavy chain Vasoactive intestinal polypeptide localized to central and peripheral Human and murine phosphorylcholine-binding immunoglobulins: neurons, 3197 Conserved subgroup and first hypervariable region of heavy chains, Hypothalamus-hypophysis 2096 Isolation, primary structure, and synthesis of a-endorphin and Immunoglobulin variant: 'y3 heavy chain disease protein CHI, 1552 -y-endorphin, two peptides of hypothalamic-hypophysial origin with Si7e differenceQ .mronurimnrunoglobulin heavy chains from morphinomimetic activity, 3942 ?)?l.I)..lI'..., .. - i, ' i'lii., :. proteins, 2109 Hypoxanthine guanine phosphoribosyltransferase Immunoglobulin kappa chain see Hypoxanthine phosphoribosyltransferase Correlations between specificity and sequence of first Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) complementarity-determining segments of human kappa light chains, Analysis of HeLa cell hypoxanthine phosphoribosyltransferase mutants 4471 and revertants by two-dimensional polyacrylamide gel electrophoresis: Immunoglobulin allotypes of rabbit kappa chains: Polymorphism of Silent gene activation, 4589 control mechanism regulating closely linked duplicated genes? 1293 Chromosome-mediated gene transfer between closely related strains of Immunoglobulin light chain cultured mouse cells, 2838 Hydrophobicity of NH2-terminal extra piece of immunoglobulin Hypoxia light-chain precursors: Physiological functions of extra piece, 3273 Sherpas living permanently at high altitude: Pattern of adaptation, 747 No detectable reiteration of genes coding for mouse MOPC 41 immunoglobulin light-chain mRNA, 727 Partial amino-acid sequence of precursor of immunoglobulin light chain I-cell disease containing NH2-terminal pyroglutamic acid, 2604 see Mucolipidosis Reiteration frequency of immunoglobulin light chain genes: Somatic I-cell virus generation of antibody diversity, 203 Enveloped virus acquires membrane defect when passaged in fibroblasts Transcription in vitro of immunoglobulin kappa light chain genes in from I-cell disease patients, 2443 isolated mouse myeloma nuclei and chromatin, 775 Imidazoleglycerolphosphate dehydratase (EC 4.2.1.19) Immunoglobulin, membrane Functional genetic expression of eukaryotic DNA in Escherichia coli, Phylogenetic origins of immune recognition: Lymphocyte surface 1471 immunoglobulins in goldfish, Carassius auratus, 2476 Immigration Immunoglobulin MOPC 460 Calculation of immigration and extinction curves from Kinetic evidence for hapten-induced conformational transition in species-area-distance relation, 4130 immunoglobulin MOPC 460, 3549 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 738(1976) SuibjectIndex 4749

Immunoglobulin,surface for translationof naturalmessengers, 44 Ontogenyof murineB lymphocytes:Sequence of B-cell differentiation Polypeptidechain initiation in eukaryotes:Mechanism of formationof from surface-immunoglobulin-negativeprecursors to plasmacells, 2008 initiationcomplex, 298 Immunologicalcrossreaction Protein synthesis in rabbitreticulocyte lysates: Inhibition of protein Immunologicalcrossreaction between alpha-fetoprotein and albumin, synthesis by translationalinhibitor from heme-deficientlysates and 4641 relationshipto initiationfactor that binds Met-tRNAf,2720 Immunologicalcrossreactivity Purificationand characterizationof two initiation factorsrequired for Specific releaseof thioesterasecomponent of fatty acid synthetase maximalactivity of highly fractionatedglobin mRNA translation multienzymecomplex by limited trypsinization,1184 system, 2584 Immunologicalsuppression of gene expression Specific in situ cleavageof 16S ribosomalRNA of Escherichiacoli Murinetype-C RNA virogenessuppressed by type-specificoncornavirus interfereswith functionof initiationfactor IF-1, 702 vaccines:Prospects for preventionof cancer,620 Initiation,synchronized Immunologicaltolerance Sequentialtranslation of nonstructuralproteins in cells infected with Inductionof immunologicaltolerance to majorantigenic determinant of SemlikiForest virus mutant, 1936 penicillin:Therapeutic approach to penicillinallergy, 2091 Inosine 5'-phosphatedehydrogenase (EC 1.2.1.14) Immunology Conformationalproperties of ribavirin,4257 Embryonalcarcinoma antigen and T/t locus of mouse,4080 Insect egg Immunoprecipitation RNase sensitivity of anteriormorphogenetic determinant in insect egg Deficiencyin plasmaprotein synthesis causedby x-ray-inducedlethal (Smittia sp., Chironomidae,Diptera), 3739 albino alleles in mouse, 3376 Insect genome Largeproduct of cell-freetranslation of messengerRNA coding for DNA sequenceorganization in lepidopteranAntheraea pernyi, 2289 corticotropin,4319 Insect, nonflying Monomermolecular weight of T antigen from simian virus 40-infected Chemo-anemotaxis:Behavioral response to sex pheromonein nonflying and transformedcells, 2254 insects, 2524 Partial amino-acidsequence of H-2K molecule,905 Insertionsequences Proteinproducts of murinechromosome 17: Partial amino acid sequence Isolationof invertedrepeat sequences,including IS1, IS2, and IS3, in of H-2Kbmolecule, 3661 Escherichiacoli plasmids,2316 Simian virus 40 tumor-specificproteins in nucleus and plasma Insulin membraneof HeLa cells infected by adenovirus2-SV40 hybrid virus see also Preproinsulin;Proinsulin; Receptor, insulin Ad2+ND2, 2505 Ability of insulin to increasecalcium binding by adipocyteplasma Immunoregulation membranes,1542 Influenceof polyunsaturatedfatty acids on survivalof skin allografts Amino-terminalsequences of two polypeptidesfrom humanserum with and tumor incidencein mice, 928 nonsuppressibleinsulin-like and cell-growth-promotingactivities: Immunosuppression Structuralhomology with insulin B chain, 4379 Preventionand suppressionby azathioprineof venom-induced Bindingof insulin to isolated nuclei, 1427 protein-losinggastropathy in dogs, 968 Dietaryand hormonalregulation of content of acetyl coenzymeA Preventionof spontaneousleukemia in AKR mice by type-specific carboxylase-synthesizingpolysomes in rat liver, 2304 immunosuppressionof endogenousecotropic virogenes, 4633 Does somatostatininhibition of insulin secretioninvolve two Immunotherapy mechanismsof action? 248 Inductionof immunologicaltolerance to majorantigenic determinant of Effect of 3':5'-cyclicAMP on glucosetransport in rat adipocytes,4359 penicillin:Therapeutic approach to penicillinallergy, 2091 Hormonalcontrol of pyruvatekinase activity and of gluconeogenesisin Indium-111 isolatedhepatocytes, 2762 Covalentattachment of metal chelates to proteins:Stability in vivo and Hormonalstimulation of DNA synthesis in primarycultures of adult rat in vitro of conjugateof albuminwith chelate of 1lindium, 3803 hepatocytes,3589 Indomethacin Hormoneresponsive human breast cancer in long-termtissue culture: ProstaglandinE synthesis in culturedhuman umbilical vein smooth Effect of insulin,4536 musclecells, 1617 Hypertrophyand hyperplasiaof somatostatin-containingD-cells in Inductionof surfacemarker diabetes, 1338 Ontogenyof murineB lymphocytes:Sequence of B-cell differentiation Insulin effect on cell cycle:Kinetics of growthparameters in confluent from surface-immunoglobulin-negativeprecursors to plasma cells, 2008 chick cells, 3173 Inelasticelectron tunneling spectroscopy Insulinrelease and phosphateion efflux from rat pancreaticislets Inelasticelectron tunneling spectroscopy of nucleic acid derivatives,1598 inducedby L-leucineand its nonmetabolizableanalogue, Inertialframe 2-aminobicyclo[2.2.1]heptane-2-carboxylicacid, 3403 Inertialframe and Lorentztransformation, 1418 Tubulin synthesis in islets of Langerhans,3188 Infection,kinetics of Insulin-likeactivity Simultaneousinitiation of synthesis of bacteriophageT4 DNA and of Nonsuppressibleinsulin-like activity and thyroid hormones:Major deoxyribonucleotides,757 pituitary-dependentsulfation factors for chick embryocartilage, 2904 Infinite-dimensionalBanach spaces Polypeptideswith nonsuppressibleinsulin-like and cell-growth Vector-valuedasymptotic martingales, 1798 promotingactivities in humanserum: Isolation, chemical Influenzavirus characterization,and biologicalproperties of forms I and II, 2365 Chromatographicisolation of hemagglutininpolypeptides from influenza Integerprogramming virus vaccineand determinationof amino-terminalsequences, 238 House monotoneapportionment schemes, 684 Influenzavirus genomeconsists of eight distinct RNA species, 3045 Integrase Mappingof influenzavirus genome:Identification of hemagglutininand Significanceof constitutiveintegrase synthesis, 887 neuraminidasegenes, 2142 Interferon Transbilayerdistribution and movementof cholesteroland phospholipid Dependenceof interferoninduction on nucleic acid conformation,3788 in membraneof influenzavirus, 391 Interferon,double-stranded RNA, and proteinphosphorylation, 3107 Virusand lectin agglutinationof erythrocytes:Spin label study of Interferon-inducedinhibition of proteinsynthesis in L-cell extracts: membranelipid-protein interactions, 3497 ATP-dependentstep in activationof inhibitorby double-stranded Inhibitorkinetics RNA, 3136 Combinedeffects of dissociableand undissociablelocal anestheticsupon Interferon:Purification and initial characterizationfrom humandiploid ATP-inducedfirefly bioluminescence,1868 cells, 520 Inhibitorof deoxyribonucleicacid synthesis Interferontreatment of mice:Enhanced expression of histocompatibility Inhibitorof DNA synthesis isolatedspecific for normaland malignant antigenson lymphoidcells, 1284 mammarycells, 2196 MessengerRNA competitionin shutoff of humaninterferon production, Inhibitorof proteinsynthesis 1621 Regulationof protein synthesis in rabbit reticulocytelysates: Thyrotropinand choleratoxin used to probe mechanismby which Purificationand initial characterizationof cyclic 3':5'-AMP interferoninitiates antiviralactivity, 3695 independentprotein kinaseof heme-regulatedtranslational inhibitor, Interganglioniccoordination 4349 Oscillatoryneuronal circuit generating locomotory rhythm, 3734 Inhibitorof proteolysis Intertwiningoperator Monomermolecular weight of T antigen from simianvirus 40-infected Classificationof irreducibletempered representations of semisimpleLie and transformedcells, 2254 groups, 2178 Inhibitor,polypeptide Intramembraneparticle Homologousinhibitors from potato tubers of serine endopeptidasesand Reconstitutionof intramembraneparticles in recombinantsof metallocarboxypeptidases,1941 erythrocyteprotein Band 3 and lipid: Effects of spectrin-actin Initiatingfactor association,3891 Molecularconcept of properdinpathway, 612 Intramolecularcrosslinking Initiationcomplex Intramolecularcrosslinking of tropomyosinvia disulfidebond formation: Polypeptidechain initiationin eukaryotes:Mechanism of formationof Evidencefor chain register(correction), 2527 initiationcomplex, 298 Intraocularpressure Initiationfactor Blood-aqueousbarrier can be circumventedby loweringintraocular Competitionbetween cellular and viral mRNAs in vitro is regulatedby pressure,638 messengerdiscriminatory initiation factor,3040 Inverseproblem Initiationfactor IF-E3 from rabbitreticulocytes: Purification and Inverseproblem for convexbodies, 1377 characterization,3005 Iodinationof protein Polypeptidechain initiation in eukaryotes:Initiation factor requirements Nicked DNA-protein complexfrom simian virus 40: Covalent attachmentof proteinto DNA and nick specificity, 1945 Downloaded by guest on October 5, 2021 4750 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Iodinationof ribonucleicacid Isorhodopsin Euglena chloroplast tRNAs: Transcriptional origin, 1984 Rapid-flow resonance Raman spectroscopy of photolabile molecules: Iodohydroxybenzylpindolol Rhodopsin and isorhodopsin, 1 (-Adrenergic receptors in rat liver: Effects of adrenalectomy, 1343 Isotachophoresis Ion binding Gram-preparative protein fractionation by isotachophoresis: Human Sequence-specific recognition of double helical nucleic acids by proteins, growth hormone isohormones isolated, 732 804 Isozyme Ion distribution Human liver and placental alkaline phosphatase isoenzymes are coded Ion distribution in subcellular myocardial particulates separated by by different genes, 2201 density gradient centrifugation with nonpolar liquid under ion Interrelationship of hexosaminidases A and B: Confirmation of common immobilization conditions, 1754 and unique subunit theory, 2833 Ionophore Lack of feedback regulation of gene activity and absence of subunit see also Sodium ionophore exchange between lactate dehydrogenase tetramers in vivo, 3618 Free acid, anion, alkali, and alkaline earth complexes of lasalocid A Loss of mouse chromosomes in somatic cell hybrids between HT-1080 (X537A) in methanol: Structural and kinetic studies at monomer level, human fibrosarcoma cells and mouse peritoneal macrophages, 3248 4277 Peroxidase complex with concomitant anodal and cathodal variation in Lasalocid A (X537A) and its silver, sodium, and barium salts: Structural red-fruited tomato species, 900 and kinetic studies in nonpolar solvents, 1786 Subunit structure and isozymic forms of -y-glutamyl transpeptidase, 2599 Potassium ionophore (valinomycin) inhibits lymphocyte proliferation by Iterativeextended Huckeltheory its effects on cell membrane, 3599 Conformational properties of ribavirin, 4257 Uncoupling in mitochondria: Uncouplers as ionophores for cycling cations and protons, 3141 Ionophoriccomplex Charge pair model of bioenergetics: Energy transfer, 2770 Jejunalmucosa, rat Ion permeability Glutathione and -y-glutamyl cycle enzymes in crypt and villus tip cells of Eel esophagus as osmoregulatory organ, 1348 rat jejunal mucosa, 420 Increased ion permeability of planar lipid bilayer membranes after Joint distributionfunction treatment with C5b-9 cytolytic attack mechanism of complement, 2852 Bounds for joint distribution function with fixed sub-distribution Iridium functions: Application to competing risks, 11 Metal cluster in catalysis: Hydrocarbon reactions, 4274 Solar abundance of iridium, 269 Iron Translational control in regulation of ferritin synthesis by iron, 857 Kahlermanifold, complete simply-connected Iron compound Structure of complete simply-connected Kahler manifolds with X-ray absorption edges in iron compounds and proteins, 1384 nonpositive curvature, 1008 Iron protein Karyoplast X-ray absorption edges in iron compounds and proteins, 1384 Nucleus-membrane interaction in capping of surface membrane Irradiation,electron receptors, 4580 Catalase monolayers inactivated by irradiation with 100 keV electrons, Ketone, neutral 823 Favorskii-Nazarov reaction of dicyclopropyl ketone, 2945 Irradiation,near ultraviolet Kidney Growth delay induced in Escherichia coli by near ultraviolet radiation, see also Cell culture, kidney 59 Effect of main artery occlusion of one kidney on blood pressure of dogs, Irradiation,ultraviolet 1722 Defective thymine dimer excision by cell-free extracts of xeroderma 15-Hydroxyprostaglandin dehydrogenase specific for prostaglandin A in pigmentosum cells, 2757 rabbit kidney, 1107 DNA single-strand breaks during repair of UV damage in human 15-Hydroxyprostaglandin dehydrogenase specific for prostaglandin A in fibroblasts and abnormalities of repair in xeroderma pigmentosum, 39 rabbit kidney (correction), 2528 Endogenous mouse type C virus activated by ultraviolet-irradiated Proline and glycine uptake by renal brushborder membrane vesicles, herpes simplex virus types I and 2, 646 4521 Postreplication repair enhanced in Chinese hamster cells, 2396 Solute and water movement in kidney, 252 Sequential transcription of genes of vesicular stomatitis virus, 1504 Kidney growth,neonatal Irradiation, x- Cyclic nucleotide metabolism in compensatory renal hypertrophy and Deficiency in plasma protein synthesis caused by x-ray-induced lethal neonatal kidney growth, 524 albino alleles in mouse, 3376 Kidney tubule DNA strand breaks, repair, and survival in x-irradiated mammalian cells, Distribution of calcitonin-sensitive adenylate cyclase activity along 809 rabbit kidney tubule, 3608 Solid tumor models for assessment of different treatment modalities: Kinetic analysis Systematics of response to radiotherapy and chemotherapy, 818 Transient change in Na ion conductivity of excitable membranes, 4492 Ischemia Kinetic formalism,steady-state Distribution of 3':5'-cyclic AMP and 3':5'-cyclic GMP in rabbit retina in Steady-state kinetic formalism applied to multienzyme complexes, vivo: Effects of dark and light adaptation and ischemia, 4442 oxidative phosphorylation, and interacting enzymes, 4432 Phosphorus nuclear magnetic resonance studies on normoxic and Kinetic proofreading ischemic cardiac tissue, 4446 Kinetic proofreading in amino acylation of tRNAIle, 1164 Island Kinetics Calculation of immigration and extinction curves from see also Enzyme kinetics species-area-distance relation, 4130 Kinetics,association Species-distance relation for birds of Solomon Archipelago, and paradox Integration of murine leukemia virus after exogenous infection, 4095 of great speciators, 2160 Kinetics, biphasic,of transport Islets of Langerhans Sodium-stimulated a-aminoisobutyric acid transport by membrane Cell-free synthesis of rat preproinsulins: Characterization and partial vesicles from simian virus-transformed mouse cells, 1907 amino acid sequence, 1964 Kinetics, chemical Insulin release and phosphate ion efflux from rat pancreatic islets Rate of quaternary structure change in hemoglobin measured by induced by L-leucine and its nonmetabolizable analogue, modulated excitation, 4497 2-lmlm;mI'!)in'i~cxi...i.1'ln !)i.iim' ?. ,?;l?x),?x]imacid, 3403 Kinetics, nucleation Partia:l pi"';-!: ali;miilil I mnRNAfor rat preproinsulin, Supersaturation in sickle cell hemoglobin solutions, 3035 3539 Kinetics, reassociation Tubulin synthesis in islets of Langerhans, 3188 DNA sequence organization in lepidopteran Antheraea pernyi, 2289 Isoenzyme Kinetics, relaxation see Isozyme Denatured tRNA2Glu from Escherichia coli, 2216 Isohormones Isolated acetylcholine receptor protein: Kinetics of binding of Gram-preparative protein fractionation by isotachophoresis: Human acetylcholine and Ca ions, 3994 growth hormone isohormones isolated, 732 Kinetics,stopped-flow Isolated singularity Hydrolysis and transpeptidation of peptide substrates by acetyl-pepsin, Bernstein polynomials and Milnor algebras, 2546 3915 Isoleucyl-tRNAsynthetase (EC 6.1.1.5) Kinetic theory Kinetic proofreading in amino acylation of tRNAIe, 1164 Kinetic theory and ergodic properties, 1802 Isoproterenol Kininogen,high-molecular-weight Abnormal levels of 3':5'-cyclic AMP in isoproterenol-stimulated Involvement of high molecular weight kininogen in surface-dependent fibroblasts from patients with cystic fibrosis, 2899 reactions of Hageman factor, 2554 Cultured tumor cells: Affinity isolation by drugs and hormones Prekallikrein and high-molecular-weight kininogen: A complex in human covalently bound to glass and Sepharose beads, 2013 plasma, 4179 Desensitization of 3-adrenergic receptors by (-adrenergic agonists in Klebsiella aerogenes cell-free system: Resensitization by guanosine Klebsiella aerogenes citrate (pro-3S)-lyase: Structure of prosthetic 5'-((,-y-imino)triphosphate and other purine nucleotides, 1494 group, 1872 Krill Genetic variability in krill, 658 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4751

Lactate patient with acute myelogenous leukemia and re-identification of Renal CO2 production from glutamine and lactate as function of arterial type-C virus (correction), 977 perfusion pressure in dog, 4235 Primate type-C virus nucleic acid sequences (woolly monkey and baboon Lactate dehydrogenase (EC 1.1.1.27) types) in tissues from patient with acute myelogenous leukemia and in Cibacron blue F3GA binds to proteins containing dinucleotide fold, 361 viruses isolated from cultured cells of same patient; 2113 Lack of feedback regulation of gene activity and absence of subunit Primate type-C virus nucleic acid sequences (wooly monkey and baboon exchange between lactate dehydrogenase tetramers in vivo, 3618 types) in tissues from patient with acute myelogenous leukemia and in Lactate dehydrogenase-elevatingvirus viruses isolated from cultured cells of same patient (correction), 3320 Antibody-producing cells: Virus-induced alteration of response to Leukemia,acute myeloid antigen, 1707 Alkaline phosphatase activity in lymphocyte, mitogen-induced blasts, Lactoperoxidase(EC 1.11.1.7) lymphoblastoid cell lines, acute myeloid leukemia, and chronic Structu'ral (shape-maintaining) role of cell surface glycoprotein of lymphatic leukemia cells, 1432 Halobacterium salinarium, 2687 LeukemiaIa antigens Lagrangianrepresentation Ia-like molecules on surface of normal and leukemic human cells, 1288 Equilibrium and stability code for a diffuse plasma, 984 Leukemia,lymphocytic LasalocidA Electron microscopic x-ray microanalysis of normal and leukemic human Free acid, anion, alkali, and alkaline earth complexes of lasalocid A lymphocytes, 3690 (X537A) in methanol: Structural and kinetic studies at monomer level, Leukemiavirus, bovine 4277 Bovine leukemia virus: Exogenous RNA oncogenic virus, 1014 Lasalocid A (X537A) and its silver, sodium, and barium salts: Structural Leukemiavirus, feline and kinetic studies in nonpolar solvents, 1786 Bur-1, a restriction locus of a type-C RNA virus in feline cellular Laser genome: Identification, location, and phenotypic characterization in Responses of Ph^-rr-cr-.-cr indicating optical excitation of lowest triplet cat X mouse somatic cell hybrids, 4618 state of r-ilt!'lm,xiil. I!iW' Leukemiavirus, Friend Laticauda semifasciata see also Friend virus Three-dimensional structure of erabutoxin b neurotoxic protein: Host restriction of Friend leukemia virus: Synthesis and integration of Inhibitor of acetylcholine receptor, 2991 provirus, 2356 Lecithin Leukemiavirus, Gross Choline synthesized from ethanolamine in rat brain, 2181 Radioimmunoassay for intact Gross mouse leukemia virus, 2847 Nuclear magnetic resonance description of molecular motion and phase Leukemiavirus, Moloney separations of cholesterol in lecithin dispersions, 3812 Alkaline phosplhatase activity in lymphocyte, mitogen-induced blasts, Lecithinacyltransferase (EC 2.3.1.43) 'lymphoblastoid cell lines, acute myeloid leukemia, and chronic Solid phase synthesis of protein activator for lecithin-cholesterol, lymphatic leukemia cells, 1432 acyltransferase corresponding to human plasma apoC-I, 1422 Germ line integration and Mendelian transmission of exogenous Lecithin-cholesterolacyltransferase Moloney leukemia virus, 1260 see Lecithin acyltransferase Mouse A9 cell clones differing in malignancy derived in vitro: Analysis Lectin by somatic cell hybridization with YACIR lymphoma cell clones, 2004 see also Concanavalin A; Phytohemagglutinin Leukemiavirus, murine Changes in cellular glycoproteins after transformation: Identification of AKR-specific sequences increased in tumor tissues of leukemic AKR specific glycoproteins and antigens in sodium dodecyl sulfate gels, 4457 mice, 2448 Effects of concanavalin A and succinylated derivative on lymphocyte Bvur-1,a restriction locus of a type-C RNA virus in feline cellular proliferation and cyclic nucleotide levels, 1717 genome: Identification, location, and phenotypic characterization in Magnetic resonance studies of concanavalin A: Binding site of cat X mouse somatic cell hybrids, 4618 Y-methyl-D-mannopyranoside, 322 Changes in expression of murine leukemia virus antigens and production Regulation of induction of T and B cell colonies in vitro by normal of xenotropic virus in the late preleukemic period in AKR mice, 4680 human lymphocytes, 4546 Fv-1 gene product: Effect on proviral DNA formation and integration in Surface membrane carbohydrate alterations of flagellated protozoan cells infected with murine leukemia viruses, 2236 mediated by bacterial endosymbiotes, 852 Gene locus modifying susceptibility to certain B-tropic murine leukemia Leech viruses, 585 see Hirudo medicinalis Heredity of Gix thymocyte antigen associated with murine leukemia Leghemoglobin virus: Segregation data simulating genetic linkage, 2077 Intracellular site of synthesis and localization of leghemoglobin in root Integration of murine leukemia virus after exogenous infection, 4095 nodules, 3843 Replication of murine leukemia virus in bone marrow-derived Legume lymphocytes, 3714 Hydrogen evolution affects efficiency of nitrogen fixation in nodulated Synthesis of murine leukemia virus proteins associated with virions symbionts, 1207 assembled in actinomycin D-treated cells: Persistence of viral Lens messenger RNA, 1154 Absence of low-molecular-weight alpha crystallin in nuclear region of old Leukemiavirus, murine, Rauscher human lenses, 3484 Fucose-deficient glycoprotein precursor to Rauscher leukemia virus Enzymatic NH2-terminal acetylation of proteins with gp69/71, 2326 des-N"l-acetyl-a-melanotropin as substrate, 3010 Radioimmunoassay for intact Gross mouse leukemia virus, 2847 Quantitation of &-crystallin messenger RNA during lens induction in Rauscher murine leukemia virus-specific polypeptides synthesized in chick embryos, 2808 vitro, 356 Lepton Leukemiavirus, radiation Deep inelastic scattering of charged leptons, 3816 Radiation leukemia virus: Biological and serological characterization, Deep inelastic scattering of leptons, 3351 4675 LETS protein Leukocyte,leukemia see Protein, large external transformation-sensitive Growth and differentiation in culture of leukemic leukocytes from a Lettuce patient with acute myelogenous leukemia and re-identification of Photosynthetic unit in lettuce, 4560 type-C virus (correction), 977 L-Leucine Subcellular localization of S-adenosyl-L-methionine:tRNA Insulin release and phosphate ion efflux from rat pancreatic islets methyltransferases with aminoacyl-tRNA synthetases in human and induced by L-leucine and its nonmetabolizable analogue, mouse: Normal and leukemic leukocytes, 3857 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid, 3403 Leukosis-virus-freeegg Leukemia RNA-dependent DNA polymerase, different from known viral reverse AKR-specific sequences increased in tumor tissues of leukemic AKR transcriptases, in chicken system, 3025 mice, 2448 Lie group Bovine leukemia virus: Exogenous RNA oncogenic virus, 1014 Classification of irreducible tempered representations of semisimple Lie Germ line integration and Mendelian transmission of exogenous groups, 2178 Moloney leukemia virus, 1260 Lifting derivation -y-Glutamyl transpeptidase, a lymphoid cell-surface marker: Relationship Lifting derivations from quotients of separable C*-algebras, 1414 to blastogenesis, differentiation, and neoplasia, 2414 Ligandbinding Modifications of purified glucose-6-phosphate dehydrogenase and other Nuclear magnetic resonance study of heme-heme interaction in enzymes by a factor of low molecular weight abundant in some hemoglobin M Milwaukee: Mechanism of cooperative ligand binding in leukemic cells, 77 normal hemoglobin, 1581 Prevention of spontaneous leukemia in AKR mice by type-specific Spectral differences between a and (3heme groups within human immunosuppression of endogenous ecotropic virogenes, 4633 deoxyhemoglobin, 1140 Simultaneous detection of reverse transcriptase and high molecular Volume changes in binding of ligands to methemoglobin and weight RNA in tissue of patients with Hodgkin's disease and in human metmyoglobin, 4271 patients with leukemia, 4649 Light adaptation Leukemia,acute lymphocytic Distribution of 3':5'-cyclic AMP and 3':5'-cyclic GMP in rabbit retina in Electrophoretic distributions of human peripheral blood mononuclear vivo: Effects of dark and light adaptation and ischemia, 4442 white cells from normal subjects and from patients with acute Light scattering lymphocytic leukemia, 2388 Application of polarization effects in light scattering, 486 Leukemia,acute myelogenous Lignin Growth and differentiation in culture of leukemic leukocytes from a Preparation and microbial decomposition of synthetic [14C]lignins (correction), 1373 Downloaded by guest on October 5, 2021 4752 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Limiting extremal erythrocyte protein Band 3 and lipid: Effects of spectrin-actin Conjugate points on a limiting extremal, 1800 association, 3891 Limits of discrete series /-Lipotropin Classification of irreducible tempered representations of semisimple Lie (-Lipotropin: Prohormone for morphinomimetic peptides endorphins groups, 2178 and enkephalins, 2156 Linoleic acid Morphinomimetic activity of synthetic fragments of (-lipotropin and Influence of polyunsaturated fatty acids on survival of skin allografts analogs, 3308 and tumor incidence in mice, 928 Opioid activity of a peptide, /-lipotropin-(61-91), derived from Linolenic acid (-lipotropin, 1821 Adenosine 3':5'-cyclic monophosphate deficiency in Neurospora crassa, Untriakontapeptide with opiate activity from camel pituitary glands, 2995 1145 Lipid bilayer Liver Increased ion permeability of planar lipid bilayer membranes after Changes in levels of cellular retinol- and retinoic-acid-binding proteins of treatment with C5b-9 cytolytic attack mechanism of complement, 2852 liver and lung during perinatal development of rat, 3976 Membrane perturbation: Calcium-sensitive dye, arsenazo III, used in Cobalt inhibition of synthesis and induction of 6-aminolevulinate liposomes, 510 synthase in liver, 1499 Subcellular localization of S-adenosyl-L-methionine:tRNA Fetal protein in chromatin of Novikoff hepatoma and Walker 256 methyltransferases with aminoacyl-tRNA synthetases in human and carcinosarcoma tumors that is absent from normal and regenerating mouse: Normal and leukemic leukocytes, 3862 rat liver, 3258 Lipid bilayer vesicle Hepatic phenylalanine 4-monooxygenase is a phosphoprotein, 1591 Inner and outer hydrocarbon chains of lipid bilayer vesicles: Direct Induction of vitellogenin synthesis by estrogen in avian liver: spectroscopic observation, 2716 Relationship between level of vitellogenin mRNA and vitellogenin Lipid fluidity synthesis, 1442 Modulation of membrane fluidity: Homogeneous catalytic hydrogenation Obligatory role of hypophysis in sexual differentiation of hepatic of' phospholipids and phospholipid-water model biomembranes, 3971 metabolism in rats, 1462 Lipid-linked oligosaccharide Vitamin A-containing lipocytes and formation of type III collagen in Biosynthesis of lipid-linked oliosr.-ach.ri:rde and glycoprotein in aorta: liver injury, 3719 Stimulation by acceptor i.ili:(!.. -.iil ii li.:: liver, 2574 Locus, T/t Lipid metabolism Embryonal carcinoma antigen and T/t locus of mouse, 4080 Fatty acyl-CoA oxidizing system in rat liver peroxisomes: Enhancement Longevity by clofibrate, a hypolipidemic drug, 2043 see also Aging Lipid-requiring auxotroph Diet: influence on survival of mice, 1279 Isolation and characterization of unsaturated fatty acid-requiring mutant Lorentz transformation of cultured mammalian cells, 24 Inertial frame and Lorentz transformation, 1418 Lipid vesicle Luciferase Asymmetric orientation of phage M13 coat protein in Escherichia coli Immobilization of bacterial luciferase and FMN reductase on glass rods, cytoplasmic membranes and in synthetic lipid vesicles, 1159 3848 Lipid vesicles as carriers for introducing materials into cultured cells: Inhibition and stimulation of development of bioluminescent system in Influence of vesicle lipid composition on mechanism(s) of vesicle Beneckea harveyi by cyclic GMP, 4454 incorporation into cells, 1603 Molecular mechanism of inhibition of firefly luminescence by local Lipocyte anesthetics, 481 Vitamin A-containing lipocytes and formation of type III collagen in Simple synthesis of 4a-hydroperoxy adduct of 1,5-dihydroflavine: Model liver imnjury,3719 for bacterial luciferase, 995 Lipolysis Luciferin Effect of 3':5'-cyclic AMP on glucose transport in rat adipocytes, 4359 Molecular mechanism of inhibition of firefly luminescence by local Lipopolysaccharide anesthetics, 481 Polyclonal activation of bone-marrow-derived lymphocytes from human Lumiflavin peripheral blood measured by direct plaque-forming cell assay, 3676 Crystal structure of complex between lumiflavin and Regulation of induction of T and B cell colonies in vitro by normal 1 di(ni.mii 09 1ill)tlri:oi': Flavin adenine dinucleotide model human lymphocytes, 4546 (xh]i)iitm hlgi- imn'ii-(lrx interactions, 3807 Replication of murine leukemia virus in bone marrow-derived Luminescence lymphocytes, 3714 Combined effects of dissociable and undissociable local anesthetics upon Lipoprotein ATP-induced firefly bioluminescence, 1868 see also Apolipoprotein Molecular mechanism of inhibition of firefly luminescence by local Cellular cholesterol ester accumulation induced by free cholesterol-rich anesthetics, 481 lipid dispersions, 3680 Simple synthesis of 4a-hydroperoxy adduct of 1,5-dihydroflavine: Model Human blood plasma protein, rich in proline, with lipid-binding for bacterial luciferase, 995 properties, 1063 Lung Molecular. weight of protein moiety in protein-detergent complexes Changes in levels of cellular retinol- and retinoic-acid-binding proteins of determined without direct knowledge of detergent binding, 4467 liver and lung during perinatal development of rat, 3976 Morphogenesis of bacterial division septum: Class of septation-defective Direct determination of surface tension in lung, 4698 mutants, 1882 Luteinizing hormone Lipoprotein, high density see Lutropin Adrenal cholesterol uptake from plasma lipoproteins: Regulation by Lutropin corticotropin, 4329 Gonadotropin from nonpregnant subjects that has physical, Apolipoproteins in rat serum and renal lymph, 1757 immunological, and biological similarities to human chorionic Lipoprotein, low density gonadotropin, 2885 Adrenal cholesterol uptake from plasma lipoproteins: Regulation by Thyrotropin-ganglioside interactions and relationship to structure and corticotropin, 4329 function of thyrotropin receptors, 842 Apolipoproteins in rat serum and renal lymph, 1757 Lycopersicon Binding, internalization, and degradation of low density lipoprotein by Peroxidase complex with concomitant anodal and cathodal variation in normal human fibroblasts and by fibroblasts from homozygous familial red-fruited tomato species, 900 hypercholesterolemia, 14 Lymph nqde Degradation of cationized low density lipoprotein and regulation of Elevated angiotensin converting enzyme in lymph nodes containing cholesterol metabolism in homozygous familial hypercholesterolemia non-necrotizing granulomas in sarcoidosis, 2137 fibroblasts, 3178 Lymphocyte Genetic variation in serum low density lipoproteins and lipid levels in Alkaline phosphatase activity in lymphocyte, mitogen-induced blasts, man, 937 lymphoblastoid cell lines, acute myeloid leukemia, and chronic Low density lipoprotein receptors localized on plasma membrane of lymphatic leukemia cells, 1432 normal human fibroblasts and their absence in cells from familial Antibody-producing cells:, Virus-induced alteration of response to hypercholesterolemia homozygote, 2434 antigen, 1707 Lipoprotein metabolism Differential effect of phosphonoacetic acid on expression of Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity Epstein-Barr viral antigens and virus, production, 1745 and cholesterol synthesis in nonhepatic tissues of rat, 2564 Effects of concanavalin A and succinylated derivative on lymphocyte Lipoprotein, very low density proliferation and cyclic nucleotide levels, 1717 Apolipoproteins in rat serum and renal lymph, 1757 Electron microscopic x-ray microanalysis of normal and leukemic human Solid phase synthesis of protein activator for lecithin-cholesterol lymphocytes, 3690 acyltransferase corresponding to human plasma apoC-I, 1422 High blood pressure related to carcinogen-induced unscheduled DNA Liposome synthesis, DNA carcinogen binding, and chromosomal aberrations in Choleragen-mediated release of trapped glucose from liposomes human lymphocytes, 2496 containing ganglioside GM1,3480 Human alpha-fetoprotein as modulatolr of human lymphocyte Membrane perturbation: Calcium-sensitive dye, arsenazo III, used in transformation: Correlation of biological potency with electrophoretic liposomes, 510 variants, 4645 Nuclear magnetic resonance studies of interaction of general anesthetics Human lymphocyte stimulation by concanavalin A: Role of valence and with 1,2-dihexadecyl-sn-glycero-3-phosphorylcholine bilayer, 3999 surface binding sites, 2118 Reconstitution of D-glucose transport catalyzed by protein fraction from Inhibitory effect of human alpha-fetoprotein on in vitro transformation human erythrocytes in sonicated liposomes, 396 of human lymphocytes, 2857 Reconstitution of intramembrane particles in recombinants of Intracellular precursor to DNA excreted by human lymphocytes, 3211 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4753

Messenger specifying sequences in DNA of chromatin subunits, 1572 ligaind to ironl, 6 Ontogetny of lymphocyte subpopulations in human fetal liver, 919 Magnetic circular dichroism of molecules in dense media: Spin-forbidden Potassium ionophore (valinomycin) inhibits lymphocyte proliferation by transitionis of carbonyl molecuiles, 2964 its effects on cell membrane, :3599 Model for cytochrome oxidase, 2206i Variations of DNA polymerases-( and -fl during prolonged stimulation Magnetic reversal of human lymphocytes, 785 Momneit equmationdescription of maginetic reversals in the earth, 4297 Lymphocyte,bone-marrow-derived Magnetic susceptibility --G(lutamyl transpeptidase, a lymphoid cell-surface marker: Relationship Model for cytochrome oxidase, 2206 to blastogenesis, differentiation, and neoplasia, 2414 Magnetohydrodynamics Induction of immunological tolerance to major antigenic determinant of Equilibrium and stability code ftr a diffuse plasma, 984 penicillin: Therapeutic approach to penicillin allergy, 2091 Maize Ontogeny of mouse B lymphocytes and inactivation by antigen of early B . Regulation of expression otf AdI gemnesin maize, 582 lymphocytes, 2462 Maize endosperm Ontogeny of murine B lymphocytes: Sequence of B-cell differentiation Zein synthesis in maize endosperm by polyribosomes attached to protein from surface-immunoglobulin-negative precursors to plasma cells, 2008 bodies, 515 Polyclonal activation of bone-marrow-derived lymphocytes from human Major histocompatibility complex peripheral blood measured by direct plaque-forming cell assay, 3676 Role of major histocompatibility complex gene products in delayed-type Regulation of induction of T and B cell colonies in vitro by normal hypersensitivity, 2486 human lymphocytes, 4546 Malate dehydrogenase (EC 1.1.1.37) Replication of murine leukemia virus in bone marrow-derived Extracytoplasmic adenylate cyclase of Bordetella pertussis, 1926 lymphocytes, 3714 Mammary gland Role of antigenic structure in cell to cell cooperation, 4184 Humani somatotropin: Biological characterization of recombinant Lymphocyte,bursa-dependent molecule, :346:3 Sequences related to immunoglobulin kappa chain messenger RNA in T Manganese cells, 2467 Proton relaxation and charge accumulation during oxygen evolution in Lymphocyte stimulation photosynthesis, 1196 l,ymphocyte stimulation: Rapid multiparameter analysis, 2881 D-Mannopyranoside, a-methyl Lymphocyte,thymus-derived Magnetic resonance studies of concanlavalin A: Binding site of Aplastic anemia: Presence in human bone marrow of cells that suppress (r-methyl-l)-mannopyranoside, :322 myelopoiesis, 2890 Mannose transfer Cells that express viral antigens but lack H-2 determinants are not lysed Biosynthesis of lipid-linked oligosaccharides and glycoprotein in aorta: by immune thymus-derived lymphocytes but are lysed by other Stimulation by acceptor lipids isolated from liver, 2574 antiviral immune attack mechanisms, 3666 a-Mannosidase (EC 3.2.1.24) -'-(Glutamyl transpeptidase, a lymphoid cell-surface marker: Relationship Specific recognition sites mediating clearance of lysosomal enzymes in to blastogenesis, differentiation, and neoplasia, 2414 tit'o, 4045 Phylogenetic origins of immune recognition: Lymphocyte surface Martensitic transformation immunoglobulins in goldfish, Carassius auratus, 2476 Conductivity and structure of bilinear organic addition compounds, 3820 Regulation of induction of T and B cell colonies in vitro by normal Mathematics human lymphocytes, 4546 see also Applied mathematical sciences Role of major histocompatibility complex gene products in delayed-type Bernstein polynomials and Milnor algebras, 2546 hypersensitivity, 2486 Classification of irreducible tempered representations of semisimple Lie Sequences related to immunoglobulin kappa chain messenger RNA in T groups, 2178 cells, 2467 (Completeness of Bergman metric and its subordinate metric, 4294 Lymphoma Conjugate points on a limiting extremal, 1800 Mouse A9 cell clones differing in malignancy derived in vitro: Analysis Delayed singularity formation for solutions of nonlinear partial by somatic cell hybridization with YACIR lymphoma cell clones, 2004 differential equations in higher dimensions, 281 Lysis Equilibrium and stability code for a diffuse plasma, 984 Suppression of lytic effect of beta lactams on Escherichia coli and other High dimensional cohomology otfdiscrete groups, 1795 bacteria, 3293 House monotone apportionment schemes, 684 Lysogeny Iifting derivations from quotients of separable C*-algebras, 1414 Significance of constitutive integrase synthesis, 887 Maximal function associated to curve (t, t'2), 1416 Lysolecithin Maximal functions associated to smooth curves, 4295 Regulation of guanylate and adenylate cyclase activities by lysolecithin, Maximal functions: Homogeneouts curves, 2176 1586 Maximal functions: Poisson integrals on symmetric spaces, 2547 Lysosome Maximal fulnctions: Spherical means, 2174 Degradation of cationized low density lipoprotein and regulation of Relation between automorphic forms on (;L(2) and GL(3), 3348 cholesterol metabolism in homozygous familial hypercholesterolemia Relativized problems with abelian phase group in topological dynamics, fibroblasts, 3178 1007 Phagosome-lysosorne fusion in cultured macrophages prevented by Structure o( complete simply-connected Kahler manif'olds with sulfatides of Mycobacterium tuberculosis, 2510 nlonpositive curvature, 1008 Specific recognition sites mediating clearance of lysosomal enzymes in Vector-valtued asymptotic martingales, 1798 vivo, 4045 Maturation promoting factor Tuimor cell proliferation inhibited by dimerized ribonuclease, 57:3 Maturation (meiosis) in small Xenopus laot,is oocytes induced by Lysozyme injection of matutration plromoting factor, 2028 Collagenase and prostaglandins produced by isolated adherent Maximal functions rheumatoid synovial cells, 945 Maximal functions associated to smooth curves, 4295 Prediction of three-dimensional structures of enzyme-substrate and Maximal functions: Homogetneotuscurves, 2176 enzyme-inhibitor complexes of lysozyme, 4261 Maximal functi ions: Poisson integrals (on symninetric spaces, 2547 Lysozyme(EC 3.2.1.17) Maximal fulnctionts: Spherical nmeanls, 2174 D)istribution of anionic sites in glomerular basement membranes: Role in Mean field equation filtration aIndattachment, 1646 Moment equation descripti(m (of magnetic reversals in the earth, 4297 Hen egg-white lysozyme: Individual carboxyl groups seen by high field Measles virus 1nuclearmagnetic resonance, 1979 Measles virus-specific IgI) anltibo)(liesitn patients with subacute Secretion of macrophage neutral proteinase enhanced by colchicine, 872 sclerosinig panencephalit is, 1297 Lysyl oxidase Medullospinal pathway Copper-induced activation of aortic lysyl oxidase in vivo, :371 ()piate a(nd stimulus-plroduced analgesia: Functiomal ailatomlivof Lytechinus pictus medull)oslinal pathway, 4685 Translation of nonpolyadenylylated messenger RNA of sea tirchin Meiosis erthbryos, 148 ('hromlosolmalgene required for killer p)lasmid expression, natinmg, aind spl)re Inaturafttion in ,Sa(clt'h(lrorm ('lS r('re(i.sia(t, 2061 Hiormonmalconltrol ()t meio)sis: Specilicity oft I-methyladeninle receptors in Macrophage start'ish mooytes, 1669 Orgailization and energy-dependent growth of microtubutles in cells, 2798 Maturatiom (mneiMsis)in small Xc'noi)s la.t's ()oo(ytesinduced I)v Magnesium injectiOIl ot' maturation promoting factor, 2()'28 Ability of insulin to increase calcium binding by adipocyte plasma lRectovery (If crown gall ttumor cells, :3562 membranes, 1542 Meiotic recombination lon distribution in subcellular myocardial particulates separated by (;enetic conlltrols of meiotic recmlltbinatioln and somatic Dl)NA metalolism density gradient centrifugation with nonpolar liquid utinderion in l)ro..op/milra oetlamno,uster, 4141) immoblilization conditions, 1754 Melanocyte stimulating hormone Mutual potentiation by magnesium and calcium of growth in animal see Melanomtropin cells, 168 Melanoma Magnetic circular dichroism ('ell surface antigens o(f human malignant melanmlna: Mixed Blue copper centers in proteins, spectroscoplic studies and structural hemadsorption assays for humoral immllnity to cultured autologous model, 1389 mllelanoma(cells, :3278 Fluorescence-detected magnetic circular dichroism of fluorescent and Melanostatin nontfluorescent molecules, 276 lPro-l,eu-(Gly-NH2 coinformation, 12):13 Magnetic circular dichroism of ferrous carbonyl adducts of cytochromes a-Melanotropin, des-Na-acetyl- P-450 and P-420 and their synthetic models: Mercaptide as fifth Enzymatic NH,-terminal acetylation oIf proteins with Downloaded by guest on October 5, 2021 4754 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

des-Nl-acetyl-o(-melanotropin as substrate, 3010 Membrane integration (-Melanotropin Detergent-soluble HLA antigens contain hydrophilic region at the Cell surface receptors for melanotropin associated with Golgi region in COOH-terminus and penultimate hydrophobic region, 2481 mouse melanoma cells, 559 Membrane, lipid Melanotropin release inhibiting factor Increased ion peoreahilitv of planar lipid bilayer membranes after see Melanostatin treatment wi: ' t -.., :' 'ytolytic attack mechanism of complement, 2852 Membrane Membrane lipid biogenesis Is(-i'lr ..^-''vch-.l]'nc- receptor protein: Kinetics of binding of Isolation and characterization of unsaturated fatty acid-requiring mutant ..l.i.. il'. , .(il, I (a ions, 3994 of cultured mammalian cells, 24 Nuclear magnetic resonance description of molecular motion and phase Membrane, mammalian separations of cholesterol in lecithin dispersions, 3812 Properties of. toxin from sea anemone Stoichactis helianthus, including Steady-state kinetic formalism applied to multienzyme complexes, specific binding to sphingomyelin, 467 oxidative phosphorylation, and interacting enzymes, 4432 Membrane methylation Subcellular localization of S-adenosyl-L-methionine:tRNA Subcellular distribution of protein carboxymethylase and its endogenous methyltransferases with aminoacyl-tRNA synthetases in human and substrates in adrenal medulla: Role in excitation-secretion coupling, mouse: Normal and leukemic leukocytes, 3862 4050 Membrane, bacterial Membrane, mitochondrial Control of development: Role of regulatory nucleotides synthesized by Antibody evidence for different conformational states of ADP,ATP membranes of Bacillus subtilis in initiation of sporulation, 331 translocator protein isolated from mitochondria, 2280 Morphogenesis of bacterial division septum: Class of septation-defective Fluidity in mitochondrial membranes: Thermotropic lateral translational mutants, 1882 motion of intramembrane particles, 1636 Membrane, basement Membrane mobility Characterization of collagen synthesized by endothelial cells in culture, Reversion from transformed to normal phenotype by inhibition of 2361 protein synthesis in rat kidney cells infected with Distribution of anionic sites in glomerular basement membranes: Role in temperature-sensitive mutant of Rous sarcoma virus, 3603 filtration and attachment, 1646 Membrane model Membrane, cell Catalase monolayers inactivated by irradiation with 100 keV electrons, see also Receptor, cell membrane 823 Coupling of catecholamine receptor from one cell with adenylate cyclase Model membranes: Lateral hapten mobility and immunochemistry, 2977 from another cell by cell fusion, 4410 Membrane mutant Lateral transport on cell membranes: Mobility of concanavalin A Mutants of Balb/c 3T3 fibroblasts defective in adhesiveness to receptors on myoblasts, 2409 substratum: Alteration in cell surface proteins, 544 Lipid vesicles as carriers for introducing materials into cultured cells: Membrane, myotube Influence of vesicle lipid composition on mechanism(s) of vesicle Lateral motion of fluorescently labeled acetylcholine receptors in incorporation into cells, 1603 membranes of developing muscle fibers, 4594 Papain cleavage site of H-2 glycoproteins, 915 Membrane, neural Potassium ionophore (valinomycin) inhibits lymphocyte proliferation by Spike-forming model of neural membrane: Computer simulation of its effects on cell membrane, 3599 additional perfused axon experiments, 100 Regulation of guanylate and adenylate cyclase activities by lysolecithin, Spike-forming model of neural membrane: Improvement in parameter 1586 values, 2264 Replication of mycoplasmavirus MVL51: Attachment of MVL51 parental Membrane, neuronal DNA to host cell membrane, 1489 Calcium binding in cerebral tissue: Sensitivity to weak environmental Retina-specific cell-aggregating factor isolated from membranes of electric fields oscillating at low frequency, 1999 embryonic neural retina tissue, 3594 Membrane particle Membrane, chloroplast Small fragments from A subunit of cholera toxin capable of activating Transitory tight binding of ATP and of committed Pi and ADP during adenylate cyclase, 2654 ATP synthesis by chloroplasts, 4314 Membrane penicillinase Membrane conductance Membrane penicillinase of Bacillus licheniformis 749/C: Sequence and Spike-forming model of neural membrane: Computer simulation of possible repeated tetrapeptide structure of phospholipopeptide region, additional perfused axon experiments, 100 1457 Spike-forming model of neural membrane: Improvement in parameter Membrane peptide values, 2264 Photosynthetic unit in lettuce, 4560 Membrane-covered cube Membrane permeability Analogue solution for electrical capacity of membrane-covered cubes in Chol!era.er- medr,^od release of trapped glucose from liposomes cubic array at high concentration, 4003 ,-'.-.iiii" . I;..I... i-' GM1,3480 Membrane, cytoplasmic Erythrocyte phosphate transport inhibited by high pressures, 2767 Asymmetric orientation of phage M13 coat protein in Escherichia coli Localization of phytochrome in etioplasts and its regulation in vitro of cytoplasmic membranes and in synthetic lipid vesicles, 1159 gibberellin levels, 138 (3-Galactosidase converted to membrane-bound state by gene fusion, Membrane, plasma 3423 Ability of insulin to increase calcium binding by adipocyte plasma Membrane defect membranes, 1542 Enveloped virus acquires membrane defect when passaged in fibroblasts Adenylate cyclase activity in LM cells by modified manipulation of from I-cell disease patients, 2443 membrane phospholipid composition in vivo, 4482 Membrane enzyme Binding of insulin to isolated nuclei, 1427 Subunit structure and isozymic forms of --glutamyl transpeptidase, 2599 Binding of Triton X-100 to diphtheria toxin, crossreacting material 45, Membrane, erythrocyte and their fragments, 4449 Erythrocyte membranes undergo cooperative, pH-sensitive state Cellulose microfibrils: Visualization of biosynthetic and orienting transitions in physiological temperature range: Evidence from Raman complexes in association with plasma membrane, 143 spectroscopy, 3558 Cholera toxin interactions with thyrotropin receptors on thyroid plasma Reconstitution of intramembrane particles in recombinants of membranes, 1679 erythrocyte protein Band 3 and lipid: Effects of spectrin-actin Concanavalin A affects expression of cell surface sialyltransferase association, 3891 activity of mouse thymocytes, 837 Virus and lectin agglutination of erythrocytes: Spin label study of Cytoplasmic microtubules in tissue culture cells appear to grow from membrane lipid-protein interactions, 3497 organizing structure towards plasma membrane, 867 Membrane excitability Low density lipoprotein receptors localized on plasma membrane of Amphipathic amines affect membrane excitability in Paramecium normal human fibroblasts and their absence in cells from familial aurelia: Role for bilayer couple, 452 hypercholesterolemia homozygote, 2434 Pharmacologic characterization of Na+ ionophores in L6 myotubes, 1355 Neurospora placumamnepmbrane ATPase is an electrogenic pump, 1485 Membrane, excitable Relationship - - ; i..,i. (ll1 - to structure and function of thyrotropin Transient change in Na ion conductivity of excitable membranes, 4492 receptors: Their absence on plasma membranes of thyroid tumor Membrane, fetal defective in thyrotropin receptor activity, 4060 Fetal membrane collagens: Two new collagen alpha chains, 2579 Simian virus 40 tumor-specific proteins in nucleus and plasma Membrane, fibroblast membrane of HeLa cells infected by adenovirus 2-SV40 hybrid virus Adenylate cyclase activity in LM cells by modified manipulation of Ad2+ND2, 2505 membrane phospholipid composition in uivo, 4482 Thyrotropin and cholera toxin used to probe mechanism by which Membrane fluidity interferon initiates antiviral activity, 3695 Model membranes: Lateral hapten mobility and immunochemistry, 2977 Membrane potential Modulation of membrane fluidity: Homogeneous catalytic hydrogenation Change in membrane potential during bacterial chemotaxis, 4387 of phospholipids and phospholipid-water model biomembranes, 3971 Electrochemical gradient of protons and its relationship to active Membrane, frog erythrocyte transport in Escherichia coli membrane vesicles, 1892 Desensitization of (3-adrenergic receptors by (-adrenergic agonists in Membrane potential dependent binding of scorpion toxin to action cell-free system: Resensitization by guanosine potential Na+ ionophore, 2682 5'-((,-y-imino)triphosphate and other purine nucleotides, 1494 Neurospora plasma membrane ATPase is an electrogenic pump, 1485 Membrane fusion Temperature dependence of four ionic processes of spike electrogenesis Freeze-fracture study of mast cell secretion, 2823 in eel electroplaques, 3554 Membrane, half- Membrane protein Analysis of membrane halves: Cholesterol, 173 Asynchronous synthesis of erythrocyte membrane proteins, 3206 Clustering and endocytosis of membrane, receptors can be induced in Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4755

mature erythrocytes of neonatal but not adult humans, 4075 and kinetic properties, 344 Interaction of integral and peripheral membrane proteins: Affinity Copper-induced activation of aortic lysyl oxidase in vivo, 371 labeling of yeast cytochrome oxidase by modified yeast cytochrome c, Interactions of heterologous nitrogenase components that generate 4334 catalytically inactive complexes, 4369 Methylation of a membrane protein involved in bacterial chemotaxis Metalloprotein electron transfer reactions: Reactivity of horse heart (correction), 977 cytochrome c with inorganic complexes, 2950 Molecular weight of protein moiety in protein-detergent complexes Structure of iron complex in methemerythrin, 349 determined without direct knowledge of detergent binding, 4467 Metallothionein mot gene product identified with Escherichia coli-lambda hybrids, 3126 Amino-acid sequence of equine renal metallothionein-IB, 3413 Reconstitution of D-glucose transport catalyzed by protein fraction from Metal, transition human erythrocytes in sonicated liposomes, 396 Metal-metal bond lengths in complexes of transition metals, 4290 Vertical displacement of membrane proteins mediated by changes in Metarhodopsin microviscosity, 4526 Assignment of locus required for flavoprotein-linked monooxygenase Membrane,sarcoplasmic reticulum expression to human chromosome 2, 4266 Elimination of rotating carrier mechanism for active transport of Ca ion Meteorite,Allende in sarcoplasmic reticulum membranes, 1532 Allende meteorite: Isotopically anomalous xenon is accompanied by Membrane, secretory vesicle normal osmium, 4253 Adenylate cyclase from secretory vesicle membranes controlled by Methanol (-adrenergic agents and nerve growth factor, 771 Free acid, anion, alkali, and alkaline earth complexes of lasalocid A Membranesplitting (X537A) in methanol: Structural and kinetic studies at monomer level, Analysis of membrane halves: Cholesterol, 173 4277 Membranestructure Methemerythrin Fluidity in mitochondrial membranes: Thermotropic lateral translational Structure of iron complex in methemerythrin, 349 motion of intramembrane particles, 1636 Methemoglobin Incorporation of fatty acids containing photosensitive groups into Volume changes in binding of ligands to methemoglobin and phospholipids of Escherichia coli, 86 metmyoglobin, 4271 Photoaffinity labeling and quaternary structure of acetylcholine receptor Methionine from Torpedo californica, 2624 Amino acids and control of nucleolar size, the activity of RNA Membrane,surface polymerase I, and DNA synthesis in liver, 3201 Surface membrane carbohydrate alterations of flagellated protozoan In vivo rates of methionine biosynthesis in transformed human and mediated by bacterial endosymbiotes, 852 malignant rat cells auxotrophic for methionine, 1523 Membranetransfer Methionyl-tRNAf binding factor Clathrin: Protein associated with intracellular transfer of membrane by Mechanism of delayed inhibition of protein synthesis in heme-deficient coated vesicles, 1255 rabbit reticulocyte lysates, 3506 Membranetranslocation Protein synthesis in reticulocyte lysates: Effects of 3':5'-cyclic AMP, Actin-like filaments and membrane rearrangement in oxyntic cells, 4032 ATP, and GTP on inhibitions induced by heme-deficiency, Membranevesicle double-stranded RNA, and a reticulocyte translational inhibitor, 1112 Electrochemical gradient of protons and its relationship to active Protein synthesis in reticulocyte lysates: Phosphorylation of transport in Escherichia coli membrane vesicles, 1892 methionyl-tRNAf binding factor by protein kinase activity of Energy-dependent binding of dansylgalactoside to lac carrier protein: translational inhibitor isolated from heme-deficient lysates, 3112 Direct binding measurements, 109 Methodology Neurospora plasma membrane ATPase is an electrogenic pump, 1485 Affinity of myosin S-1 for F-actin, measured by time-resolved Proline and glycine uptake by renal brushborder membrane vesicles, fluorescence anisotropy, 133 4521 Affinity of myosin S-1 for F-actin, measured by time-resolved Regulation of active . ..limiiiii-.li t r'it- ac'id transport expressed in fluorescence anisotropy (correction), 2527 membrane vesicles I'ro!l ll)ii- X'ill)mrl)m

autoradiographic [14C]deoxyglucose technique, 4230 microviscosity, 4526 Method for cloning eukaryotic structural gene sequences, 3146 Mitochondria Modulation of membrane fluidity: Homogeneous catalytic hydrogenation see also Deoxyribonucleic acid, mitochondrial of phospholipids and phospholipid-water model biomembranes, 3971 Antibody evidence for different conformational states of ADP,ATP Molecular weight of protein moiety in protein-detergent complexes translocator protein isolated from mitochondria, 2280 determined without direct knowledge of detergent binding, 4467 Bioenergetics in clinical medicine: Prevention by forms of coenzyme Q of Molecular weights determined by fluctuation spectroscopy: Application inhibition by adriamycin of coenzyme Q1o-enzymes in mitochondria of to DNA, 2776 myocardium, 4653 Monovalent derivatives of concanavalin A, 790 Biogenesis of mitochondria: Molecular mapping of mitochondrial genome Negative homotropic cooperativity and affinity heterogeneity: of yeast, 2082 Preparation of yeast glyceraldehyde-3-phosphate dehydrogenase with Fluidity in mitochondrial membranes: Thermotropic lateral translational maximal affinity homogeneity, 3928 motion of intramembrane particles, 1636 Nucleotide sequences beyond sites of transcriptional termination, 717 Interaction of integral and peripheral membrane proteins: Affinity Phytochrome-mediated de novo synthesis of phenylalanine labeling of yeast cytochrome oxidase by modified yeast cytochrome c, ammonia-lyase: An approach using pre-induced mustard seedlings, 4334 4017 Mitochondrial protein synthesis regulated by cytoplasmic proteins, 3947 Platinum binds selectively to phosphorothioate groups in mono- and Modified recombination and transmission of mitochondrial genetic polynucleotides: General method for heavy metal staining of specific markers in rho minus mutants of Saccharomyces cerevisiae, 4608 nucleotides, 2536 Oxidation of ferrocytochrome c by mitochondrial cytochrome c oxidase, Polyclonal activation of bone-marrow-derived lymphocytes from human 113 peripheral blood measured by direct plaque-forming cell assay, 3676 Primary structure of two cytochromes c2: Close similarity to functionally Primary transcripts in Ehrlich ascites cells measured by tetraphosphate unrelated mitochondrial cytochrome c, 472 determination, 1994 Proliferation of Rous sarcoma virus-infected, but not of normal, chicken Prophage X induction in Escherichia coli K12 envA uvrB: Sensitive test fibroblasts in oxygen-enriched environment, 1265 for potential carcinogens, 3700 Stoichiometric relationship between energy-dependent proton ejection Radioimmunoassay for intact Gross mouse leukemia virus, 2847 and electron transport in mitochondria, 437 Rapid-flow resonance Raman spectroscopy of photolabile molecules: Uncoupling in mitochondria: Uncouplers as ionophores for cycling Rhodopsin and isorhodopsin, I cations and protons, 3141 Resonance enhanced coherent anti-Stokes Raman scattering, 3798 Mitogenesis Restriction assay for integrative recombination of bacteriophage X DNA Alkaline phosphatase activity in lymphocyte, mitogen-induced blasts, in vitro: Requirement for closed circular DNA substrate, 3524 lymphoblastoid cell lines, acute myeloid leukemia, and chronic Screening by negative chemical ionization mass spectrometry for lymphatic leukemia cells, 1432 environmental contamination with toxic residues: Application to Insulin effect on cell cycle: Kinetics of growth parameters in confluent human urines, 1777 chick cells, 3173 Subnuclear systems for synthesis of simian virus 40 DNA in vitro, 4392 Monovalent derivatives of concanavalin A, 790 Targeted attachment of peptides and proteins to solid supports, 3516 Potassium ionophore (valinomycin) inhibits lymphocyte proliferation by Transfer of tRNAs to somatic cells mediated by Sendai-virus-induced its effects on cell membrane, 3599 fusion, 2793 Mitotic drugs Methoxyflurane Cytoplasmic microtubules in tissue culture cells appear to grow from Nuclear magnetic resonance studies of interaction of general anesthetics organizing structure towards plasma membrane, 867 with 1,2-dihexadecyl-sn-glycero-3-phosphorylcholine bilayer, 3999 Modulated excitation 1-Methyladenine Rate of quaternary structure change in hemoglobin measured by Hormonal control of meiosis: Specificity of 1-methyladenine receptors in modulated excitation, 4497 starfish oocytes, 1669 Molal volume 3-Methylcholanthrene Viscosity of dilute gases and vapors, 4302 Activation of 3':5'-cyclic AMP-dependent protein kinase and induction Molecular cluster of ornithine decarboxylase as early events in induction of van der Waals-type equation of state for fluids with associating mixed-function oxygenases, 1241 molecules, 1773 Enzyme catalyzed covalent binding of benzo[a]pyrene to poly(G), 1117 Molecular conformation Methyl methanesulfonate Intramolecular energy transfer and molecular conformation, 271 Recombination in Saccharomyces cerevisiae: DNA repair mutation Molecular hybridization associated with elevated mitotic gene conversion, 2828 Biogenesis of mitochondria: Molecular mapping of mitochondrial genome Metmyoglobin of yeast, 2082 Volume changes in binding of ligands to methemoglobin and Induction of mouse type-C virus by translational inhibitors: metmyoglobin, 4271 Transcriptional derepression of specific class of endogenous virus, 4541 Microdensitometry Lack of feedback regulation of gene activity and absence of subunit Cytoarchitectonic mapping by microdensitometry, 2928 exchange between lactate dehydrogenase tetramers in vivo, 3618 Microdomain Primate type-C virus nucleic acid sequences (woolly monkey and baboon Conductivity and structure of bilinear organic addition compounds, 3820 types) in tissues from patient with acute myelogenous leukemia and in Microfibril viruses isolated from cultured cells of same patient, 2113 Cellulose biosynthesis in Acetobacter xylinum: Visualization of site of Primate type-C virus nucleic acid sequences (wooly monkey and baboon synthesis and direct measurement of in vivo process, 4565 types) in tissues from patient with acute myelogenous leukemia and in Structure and transformation of chitin synthase particles (chitosomes) viruses isolated from cultured cells of same patient (correction), 3320 during microfibril synthesis in vitro, 4570 Molecular motion Microfilament Nluclo,.r rrinr. tic resonance description of molecular motion and phase Microfilament organization and surface topography: Changes upon h?l :;tl i .::-, I c'holesterol in lecithin dispersions, 3812 transformation of chick embryo fibroblasts with Rous sarcoma virus, Molecular orbital 4065 Magnetic circular dichroism of molecules in dense media: Spin-forbidden Reversion from transformed to normal phenotype by inhibition of transitions of carbonyl molecules, 2964 protein synthesis in rat kidney cells infected with Ultraviolet photoelectron studies of biological purines: Valence electronic temperature-sensitive mutant of Rous sarcoma virus, 3603 structure of adenine, 2966 Temperature-sensitive changes in surface modulating assemblies of Molecular orbital method fibroblasts transformed by mutants of Rous sarcoma virus, 2047 Molecular orbital studies of enzyme activity: Catalytic mechanism of (32-Microglobulin serine proteinases, 432 Structure of HLA antigens: Amino-acid and carbohydrate compositions Molecular weight determination and NH2-terminal sequences of four antigen preparations, 910 Molecular weight of protein moiety in protein-detergent complexes Microsome, liver determined without direct knowledge of detergent binding, 4467 Hydrocarbon structure in enzyme-catalyzed benzo[a]pyrene-poly(G) Molecular weights determined by fluctuation spectroscopy: Application covalent complex, 1437 to DNA, 2776 Microtubule Mollusk shell protein Cytoplasmic microtubules in tissue culture cells appear to grow from Characterization of 80-million-year-old mollusk shell proteins, 2541 organizing structure towards plasma membrane, 867 Moment equation Enhanced labeling of retinal protein during regeneration of optic nerve Moment equation description of magnetic reversals in the earth, 4297 in goldfish, 828 Morphine Organization and energy-dependent growth of microtubules in cells, 2798 see also Antibody against morphine; Apomorphine P,l-c.nir-. 'nd:^cd assembly of purified tubulin, 2813 Antibodies as a means of isolating and characterizing biologically active l, '.?'-:.'..-i : .," polymerization of tubulin from cultured cell clone substances: Nonpeptide, morphine-like compound in central nervous (rat glial cell clone C6), 1227 system, 2132 Tubulir evothe-ic in ;l]et of Langerhans, 3188 Endogenous opiate analgesic isolated from human blood, 2226 Virus ;:!:il !-i ',l

Preliminary analysis of 1H and 13C spectral and relaxation behavior in mammalianintestinal muscle,4239 methionine-enkephalin, 2589 Mushroom Untriakontapeptide with opiate activity from camel pituitary glands, see Amanitaphalloides 1145 Mustardseedling Morphine-likeactivity Phytochrome-mediatedde novo synthesis of phenylalanine Isolation, primary structure, and synthesis of cy-endorphin and ammonia-lyase:An approachusing pre-induced mustardseedlings, -y-endorphin, two peptides of hypothalamic-hypophysial origin with 4017 morphinomimetic activity, 3942 Mutagen Morphinomimetic activity of synthetic fragments of (-lipotropin and Carcinogensas mutagensin Salmonella/microsometest: Assay of 300 analogs, 3308 chemicals,950 Morphine-likecompound Geneticcontrols of meiotic recombinationand somatic DNA metabolism Morphine-like peptides in mammalian brain: Isolation, structure in Drosophilamelanogaster, 4140 elucidation, and interactions with opiate receptor, 2515 Mutagenesis,acid Morphine-like peptides in mammalian brain: Isolation, structure Heat mutagenesisin bacteriophageT4: Transversionpathway, 4159 elucidation, and interactions with opiate receptor (correction), 4247 Mutagenesis,chemical Morphogenesis Incorporationof 5-fluorocytidinein RNA of 5-fluorouracil-treated Collagen fibrillogenesis: Intermediate aggregates and suprafibrillar order, eukaryoticcells, 1528 4027 Mutabilityof differentgenetic loci in mammaliancells by metabolically Retina-specific cell-aggregating factor isolated from membranes of activatedcarcinogenic polycyclic hydrocarbons, 188 embryonic neural retina tissue, 3594 Mutagenicityof aflatoxinsrelated to their metabolismand carcinogenic Motility potential, 2241 mot gene product identified with Escherichia coli-lambda hybrids, 3126 Mutagenesis,heat Mountains Heat mutagenesisin bacteriophageT4: Transitionpathway, 1269 Birds on islands in the sky: Origin of montane avifauna of Northern Heat mutagenesisin bacteriophageT4: Transversionpathway, 4159 Melanesia, 1765 Mutagenicity,environmental Mouse Aryl 4-monooxygenaseand cytochromeP-450 in aorta:Role in see Mus cervicolor atherosclerosis,3723 Mouse,AKR Mutagenicityof cations Changes in expression of murine leukemia virus antigens and production Metal-inducedinfidelity during DNA synthesis, 2331 of xenotropic virus in the late preleukemic period in AKR mice, 4680 Mutant, hypoxanthinephosphoribosyltransferase Mouse, ob/ob Analysisof HeLa cell hypoxanthinephosphoribosyltransferase mutants Diabetogenic peptide from human growth hormone: Partial purification and revertantsby two-dimensionalpolyacrylamide gel electrophoresis: from peptic digest and long-term action in ob/ob mice, 4706 Silent gene activation,4589 Mucolipidosis Mutation Enveloped virus acquires membrane defect when passaged in fibroblasts Evolutionof continuousvariation: Direct approachthrough joint from I-cell disease patients, 2443 distributionof genotypesand phenotypes,1689 Mucopolysaccharidosis Mutation,deletion Mucopolysaccharidoses (A Review), 630 Deletionsof lambdaphage locating a prm mutationwithin rightward Mucopolysaccharidoses (A Review) (correction), 2165 operator, 712 Mucor rouxii Independentregulation of endogenousand exogenousavian RNA tumor Structure and transformation of chitin synthase particles (chitosomes) virus genes, 2259 during microfibril synthesis in vitro, 4570 Mutation,Drosophila Multienzymecomplex dunce, a mutant of Drosophiladeficient in learning,1684 Specific release of thioesterase component of fatty acid synthetase Geneticcontrols of meiotic recombinationand somatic DNA metabolism multienzyme complex by limited trypsinization, 1184 in Drosophilamelanogaster, 4140 Steady-state kinetic formalism applied to multienzyme complexes, Mutation,Escherichia coli oxidative phosphorylation, and interacting enzymes, 4432 Mutant of Escherichiacoli with altered elongationfactor Tu, 1698 Mung bean Mutation,frameshift see Phaseolus aureus, Roxb. HemoglobinWayne: Frameshift mutation detected in human Muramidase hemoglobinalpha chains, 882 Oligomeric intermediate in peptidoglycan biosynthesis in Bacillus Mutation,lethal albino megaterium, 4200 Deficiencyin plasmaprotein synthesis caused by x-ray-inducedlethal Murein albino alleles in mouse,3376 Morphogenesis of bacterial division septum: Class of septation-defective Mutation,mouse mutants, 1882 Abnormalornithine carbamoyltransferase in mice havingsparse-fur Mureinhydrolases mutation,1693 Suppression of lytic effect of beta lactams on Escherichia coli and other Purkinjecell degeneration,neurological mutation in mouse, 208 bacteria, 3293 Mutation,radiation-induced Mus cervicolor Radiation-inducedmutations at mouse hemoglobinloci, 2843 Genetically transmitted retravirus isolated from Mus cervicolor, 3579 Mutationrate Muscle Infinite allele model with varyingmutation rate, 4164 see also Cell culture, smooth muscle; Cell, muscle; Filament, muscle Mutation,somatic Musclecell, striated Carcinogensas mutagensin Salmonella/microsometest: Assay of 300 Synapse formation between clonal neuroblastoma X glioma hybrid cells chemicals,950 and striated muscle cells, 123 Mutation,spontaneous Musclecontraction Heat mutagenesisin bacteriophageT4: Transitionpathway, 1269 Free energy levels and entropy production associated with biochemical Heat mutagenesisin bacteriophageT4: Transversionpathway, 4159 kinetic diagrams, 95 Mutation,temperature-sensitive Free energy levels and entropy production in muscle contraction and in Alterationsin surfaceglycoproteins and level of sialyltransferaseof cells related solution systems, 336 transformedby temperature-sensitivemutant of simian virus 40, 4090 Free energy levels and entropy production in muscle contraction and in Coordinateregulation of synthesis of eukaryoticribosomal proteins, 1547 related solution systems (correction), 2165 Myastheniagravis Muscle,denervated Experimentalmyasthenia in Balb/c mice immunizedwith rat Experimental myasthenia in Balb/c mice immunized with rat acetylcholinereceptor from rat denervatedmuscle, 2872 acetylcholine receptor from rat denervated muscle, 2872 Humanmyasthenia gravis: Electrophysiological and ultrastructural Muscle, denervated mouse extensor digitorum longus evidencecompatible with antibodylabeling of acetylcholinereceptor Synthesis of acetylcholine receptors by cultured chick myotubes and complex,4584 denervated mouse extensor digitorum longus muscles, 161 Mycobacterium phlei Muscle fiber Restorationof oxidativephosphorylation by purified Force-velocity characteristics for calcium-activated mammalian N,N'-dicyclohexylcarbodiimide-sensitivelatent slow-twitch and fast-twitch skeletal fibers from the guinea pig, 4693 adenosinetriphosphatasefrom Mycobacteriumphlei, 3050 Lateral motion of fluorescently labeled acetylcholine receptors in Mycobacterium tuberculosis membranes of developing muscle fibers, 4594 Phagosome-lysosomefusion in culturedmacrophages prevented by Reciprocal reactivities of specific thiols when actin binds to myosin, 302 sulfatides of Mycobacteriumtuberculosis, 2510 Muscle, frog sartorius Mycoplasma X-ray diffraction of' actively shortening muscle, 813 MouseA9 cell clones differingin malignancyderived in vitro:Analysis Muscle,mammalian intestinal by somatic cell hybridizationwith YACIRlymphoma cell clones, 2004 Relation between oxidative metabolism and slow rhythmic potentials in MycoplasmavirusMVL51 mammalian intestinal muscle, 4239 Replicationof mycoplasmavirusMVL51: Attachment of MVL51parental Muscle,skeletal DNA to host cell membrane,1489 l,N6-Etheno-AMP and 1,N5-etheno-2'-deoxy-AMP as probes of activator Mycovirusexclusion site of glycogen phosphorylase from rabbit skeletal muscle, 2696 Inheritanceof killer phenotypesand double-strandedRNA in Ustilago Muscle,smooth maydis, 594 Myosin-mediated Ca++-regulaton of Myeloma actomyosin-adenosinetriphosphatase from porcine aorta, 2706 y-Glutamyltranspeptidase, a lymphoidcell-surface marker: Relationship Prostaglandin E synthesis in cultured human umbilical vein smooth to blastogenesis,differentiation, and neoplasia,2414 muscle cells, 1617 Partialamino-acid sequence of precursorof immunoglobulinlight chain Relationbetween oxidative metabolism and slow rhythmicpotentials in containingNH2-terminal pyroglutamic acid, 2604 Downloaded by guest on October 5, 2021 4758 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Myeloma MOPC 41, mouse Negative chemical ionization mass spectrometry No detectable reiteration of genes coding for mouse MOPC 41 Screening by negative chemical ionization mass spectrometry for immunoglobulin light-chain mRNA, 727 environmental contamination with toxic residues: Application to Myeloma protein human urines, 1777 Subunit interactions in mouse myeloma proteins with anti-galactan Neoplasia activity, 932 -y-Glutamyl transpeptidase, a lymphoid cell-surface marker: Relationship Myeloma protein, phosphorylcholine-binding to blastogenesis, differentiation, and neoplasia, 2414 Attempts to locate residues in complementarity-determining regions of Nerve conduction antibody combining sites that make contact with antigen, 617 Sea anemone toxin: Molecular mechanisms of nerve conduction and Myelopoiesis excitation-secretion coupling, 4055 Aplastic anemia: Presence in human bone marrow of cells that suppress Nerve ending myelopoiesis, 2890 Catecholamine-stimulated cyclic GMP accumulation in rat pineal: Myenteric plexus Apparent presynaptic site of action, 3398 Morphinomimetic activity of synthetic fragments of (-lipotropin and Nerve excitability analogs, 3308 Transduction of chemical into electrical energy, 82 Myoblast Nerve excitation Lateral transport on cell membranes: Mobility of concanavalin A Transient change in Na ion conductivity of excitable membranes, 4492 receptors on myoblasts, 2409 Nerve growth factor Phenotypic transformation of clonal myogenic cells to cells resembling Adenylate cyclase from secretory vesicle membranes controlled by chondrocytes, 1989 3-adrenergic agents and nerve growth factor, 771 Myocardium ce-Adrenergic regulation of secretion of mouse saliva rich in nerve growth Ion distribution in subcellular myocardial particulates separated by factor, 4210 density gradient centrifugation with nonpolar liquid under ion Applications of synchrotron radiation to protein crystallography, 128 immobilization conditions, 1754 Noradrenergic clonal line of rat adrenal pheochromocytoma cells Myocyte established which respond to nerve growth factor, 2424 Chemical transmission between rat sympathetic neurons and cardiac Nerve terminal myocytes developing in microcultures: Evidence for cholinergic, Evoked neurotransmitter release: Statistical effects of nonuniformity and adrenergic, and dual-function neurons, 4225 nonstationarity, 2913 Rat sympathetic neurons and cardiac myocytes developing in Evoked neurotransmitter release: Statistical effects of nonuniformity and microcultures: Correlation of fine structure of endings with nonstationarity (correction), 3320 neurotransmitter function in single neurons, 4220 Nervous system Myofilament lattice see also Adrenergic nervous system; Autonomic nervous system; Central X-ray diffraction of actively shortening muscle, 813 nervous system Myogenesis Genetically determined protein polymorphism in rabbit nervous system, Chick cytoplasmic actin and muscle actin have different structural genes, 3641 2346 Gradient of adhesive specificity in developing avian retina, 410 Protein synthesis and actin heterogeneity in calf muscle cells in culture, Neuraminidase (EC 3.2.1.18) 2018 Differential labeling of cell surface of single ciliary ganglion neurons in Synthesis of polypeptides with properties of myosin light chains directed vitro, 4100 by RNA extracted from muscle cultures, 4599 Neurite Myosin Noradrenergic clonal line of rat adrenal pheochromocytoma cells see also Heavy meromyosin; Paramyosin; Tropomyosin established which respond to nerve growth factor, 2424 Calcium control of actin-activated myosin adenosine triphosphatase from Neurobiology Dictyostelium discoideum, 2321 e(-Adrenergic regulation of secretion of mouse saliva rich in nerve growth Concanavalin-A-induced transmembrane linkage of concanavalin A factor, 4210 surface receptors to intracellular myosin-containing filaments, 4575 Chemical transmission bet.ween rot ^y-mpatihtic neurons and cardiac Free energy levels and entropy production in muscle contraction and in myocytes developing in i:i, r'i, il ir-: I:-'.I.., l for cholinergic, related solution systems, 336 adrenergic, and dual-function neurons, 4225 Free energy levels and entropy production in muscle contraction and in Metabolic mapping of primary visual system of monkey by related solution systems (correction), 2165 autoradiographic [14C]deoxyglucose technique, 4230 Myosin-mediated Ca++-regulaton of Opiate and stimulus-produced analgesia: Functional anatomy of actomyosin-adenosinetriphosphatase from porcine aorta, 2706 medullospinal pathway, 4685 Myosin-paramyosin cofilaments: Enzymatic interactions with F-actin, Opiate receptor: Model explaining structure-activity relationships of 3015 opiate agonists and antagonists, 4215 Reciprocal reactivities of specific thiols when actin binds to myosin, 302 Rat sympathetic neurons and cardiac myocytes developing in Synthesis of polypeptides with properties of myosin light chains directed microcultures: Correlation of fine structure of endings with by RNA extracted from muscle cultures, 4599 neurotransmitter function in single neurons, 4220 Myosin subfragment 1 Neurofilament Affinity of myosin S-1 for F-actin, measured by time-resolved Biochemistry of filaments of brain, 529 fluorescence anisotropy, 133 Neurofilament protein localized in neuroblastoma cells by Affinity of myosin S-1 for F-actin, measured by time-resolved immunofluorescent staining, 3192 fluorescence anisotropy (correction), 2527 Neurogenetics Myotube Neurophysiological defects in temperature-sensitive paralytic mutants of Lateral motion of fluorescently labeled acetylcholine receptors in Drosophila melanogaster, 3253 membranes of developing muscle fibers, 4594 Neurohypophyseal hormone Pharmacologic characterization of Na+ ionophores in L6 myotubes, 1355 Third amino acid residue of oxytocin is important for action on isolated Synthesis of acetylcholine receptors by cultured chick myotubes and rat uterus: Relationship between hormone conformation and activity, denervated mouse extensor digitorum longus muscles, 161 3054 Neuroleptic Dopamine receptors in human and calf brains, using [3H]apomorphine NADH-oxidase and an antipsychotic drug, 4354 Bioenergetics in clinical medicine: Prevention by forms of coenzyme Q of Neuromuscular development inhibition by adriamycin of coenzyme Qo1-enzymes in mitochondria of Lateral motion of fluorescently labeled acetylcholine receptors in myocardium, 4653 membranes of developing muscle fibers, 4594 Naja naja Neuromuscular junction Prevention and suppression by azathioprine of venom-induced Experimental myasthenia in Balb/c mice immunized with rat protein-losing gastropathy in dogs, 968 acetylcholine receptor from rat denervated muscle, 2872 Naloxone Human myasthenia gravis: Electrophysiological and ultrastructural Opiate receptor: Model explaining structure-activity relationships of evidence compatible with antibody attachment to acetylcholine opiate agonists and antagonists, 4215 receptor complex, 4584 Naphila clavipes N.r!'- ..j-: ,I,i-.:i-:" d(-ftl '- in temperature-sensitive paralytic mutants of Ploy and counterploy in predator-prey interactions: Orb-weaving spiders !? - :,; : - .': .. -.' -, 3253 versus bomblardier beetles, 1365 Neuron Narcotic dependence Acetylcholine receptors: Localization during synaptogenesis in retina, Tolerance and dependence evoked by endogenous opiate peptide, 3165 1806 National Academy of Sciences USA Development of action potential mechanism of amphibian neurons National Academy of Sciences USA: Annual meeting, April 1976, isolated in culture, 1641 scientific program, 3325 Synapse and acetylcholine receptor synthesis by neurons dissociated National Academy of Sciences USA: Classes, council, members, officers, from retina, 2370 sections, 3750 Vasoactive intestinal polypeptide localized to central and peripheral Natural selection neurons, 3197 Darwin's finches: Population variation and natural selection, 257 Neuron, adrenergic Evolution of universal genetic code, 2336 Chemical transmission between rat sympathetic neurons and cardiac Sex ratio, sex change, and natural selection, 3656 myocytes developing in microcultures: Evidence for cholinergic, Near-infrared spectra adrenergic, and dual-function neurons, 4225 Blue copper centers in proteins, spectroscopic studies and structural Neuronal circuit, oscillatory model, 1389 Oscillatory neuronal circuit generating locomotory rhythm, 3734 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4759

Neuronal photoresponse Apparent presynaptic site of action, 3398 Parietal eye of lizard: Neuronal photoresponses and feedback from Norm estimate pineal gland, 654 Maximal function associated to curve (t, t2), 1416 Neuron, cholinergic Novobiocin Chemical transmission between rat sympathetic neurons and cardiac Novobiocinand coumermycininhibit DNA supercoilingcatalyzed by myocytes developing in microcultures: Evidence for cholinergic, DNA gyrase,4474 adrenergic, and dual-function neurons, 4225 Nuclearfusion Innervation of heart cells in culture by endogenous source of cholinergic Saccharomycescerevisiae mutant defective for nuclearfusion, 3651 neurons, 4506 Nuclearmagnetic relaxation time Neuron, ciliary ganglion Magneticresonance studies of concanavalinA: Bindingsite of Differential labeling of cell surface of single ciliary ganglion neurons in iv-methyl-D-mannopyranoside,322 vitro, 4100 Nuclearmagnetic resonance Neuron, dorsal horn DenaturedtRNA2Gl" from Escherichiacoli, 2216 Opiate and stimulus-produced analgesia: Functional anatomy of Hen egg-whitelysozyme: Individual carboxyl groups seen by high field medullospinal pathway, 4685 nuclearmagnetic resonance, 1979 Neuron, sympathetic lac repressor:3-Fluorotyrosine substitution for nuclearmagnetic Central regulation of sympathetic neuron development, 3575 resonancestudies, 3471 Chemical transmission between rat sympathetic neurons and cardiac LasalocidA (X537A)and its silver,sodium, and bariumsalts: Structural myocytes developing in microcultures: Evidence for cholinergic, and kinetic studies in nonpolarsolvents, 1786 adrenergic, and dual-function neurons, 4225 15N nuclearmagnetic resonance investigations on amino acids, 1409 Rat sympathetic neurons and cardiac myocytes developing in Nuclearmagnetic resonance description of molecularmotion and phase microcultures: Correlation of fine structure of endings with separationsof cholesterolin lecithin dispersions,3812 neurotransmitter function in single neurons, 4220 Nuclearmagnetic resonance studies of helix-coil transitionof Neurospora crassa poly(dA-dT)in aqueoussolution, 674 Adenosine 3':5'-cyclic monophosphate deficiency in Neurospora crassa, Nuclearmagnetic resonance studies of slowly exchangingpeptide 2995 protonsin cytochromec in aqueoussolution, 1398 Neurospora plasma membrane ATPase is an electrogenic pump, 1485 Nuclearmagnetic resonance studies of interactionof generalanesthetics Neurotensin with 1,2-dihexadecyl-sn-glycero-3-phosphorylcholinebilayer, 3999 Synthesis and activities of neurotensin, and its acid and amide analogs: Nuclearmagnetic resonance study of heme-heme interactionin Possible natural occurrence of [Gln4]-neurotensin, 3833 hemoglobinM Milwaukee:Mechanism of cooperativeligand bindingin normalhemoglobin, 1581 Neurotoxin normoxicand 3-Bungarotoxin, pre-synaptic toxin with enzymatic activity, 178 Phosphorusnuclear magnetic resonance studies on Mechanism of action of (-bungarotoxin on synaptosomal preparations, ischemiccardiac tissue, 4446 2664 Preliminaryanalysis of 1H and l3C spectraland relaxationbehavior in Sea anemone toxin: Molecular mechanisms of nerve conduction and methionine-enkephalin,2589 excitation-secretion coupling, 4055 Uncouplingof local field spectrain nuclearmagnetic resonance: Three-dimensional structure of erabutoxin b neurotoxic protein: Determinationof atomic positions in solids, 1394 Inhibitor of acetylcholine receptor, 2991 Nuclear medicine Neurotransmitter Structuralcharacterization of bridged99Tc-Sn-dimethylglyoxime Chemical transmission between rat sympathetic neurons and cardiac complex:Chemistry of 99mTc-radiopharmaceuticalsprepared by Sn(II) myocytes developing in microcultures: Evidence for cholinergic, reductionof pertechnetate,4287 adrenergic, and dual-function neurons, 4225 Nuclear particle Cross inhibitory interactions of potential mediators of hormone and mRNA sequencesin nuclear30S ribonucleoproteinsubcomplexes, 2725 neurotransmitter action, 2982 Nuclease Evoked neurotransmitter release: Statistical effects of nonuniformity and see also Endonuclease nonstationarity, 2913 Nucleaselimit digestionpattern of chromatin,3391 Evoked neurotransmitter release: Statistical effects of nonuniformity and Nucleic acid analog nonstationarity (correction), 3320 Dependenceof interferoninduction on nucleic acid conformation,3788 Hormone and neurotransmitter receptors in established vascular Nucleic acid conformation endothelial cell line, 1612 Dependenceof interferoninduction on nucleic acid conformation,3788 Rat sympathetic neurons and cardiac myocytes developing in Nucleic acid derivative microcultures: Correlation of fine structure of endings with Inelasticelectron tunneling spectroscopy of nucleic acid derivatives,1598 neurotransmitter function in single neurons, 4220 Nucleic acid, double helical Sea anemone toxin: Molecular mechanisms of nerve conduction and Sequence-specificrecognition of double helical nucleic acids by proteins, excitation-secretion coupling, 4055 804 Triiodothyronine localized in nerve ending fractions of rat brain, 941 Nucleic acid structure Neutron low angle scattering Conformationalchanges in poly[d(A-T).d(A-T)]in premeltingregion, Low resolution model for 50S subunit of Escherichia coli ribosomes, 3453 2379 Nucleofilament Nicotinamide adenine dinucleotide Chromatin:Solenoidal model for superstructure,1897 of nicotinamide adenine dinucleotide by choleragen and its A Nucleolus Hydrolysis of RNA protomer: Role in activation of adenylate cyclase, 4424 Aminoacids and controlof nucleolarsize, the activity Nicotinamide-adenine dinucleotide (oxidized) polymeraseI, and DNA synthesis in liver, 3201 Covalent modification of proteins by metabolites of NAD+, 3131 Expressionof humanand suppressionof mouse nucleolusorganizer Negative homotropic cooperativity and affinity heterogeneity: activity in mouse-humansomatic cell hybrids,4531 Preparation of yeast glyceraldehyde-3-phosphate dehydrogenase with Nucleoprotein maximal affinity homogeneity, 3928 Simianvirus 40 DNA: In vitro replicationin nucleoproteincomplex, Nicotinamide adenine dinucleotide (reduced) 3466 Immobilization of bacterial luciferase and FMN reductase on glass rods, Nucleoproteinstructure 3848 Chromatin-likeorganization of adenoviruschromosome, 401 Nucleosidemonophosphatekinase (EC 2.7.4.4) Nicotinamide analogue RNA Phenotypic transformation of clonal myogenic cells to cells resembling Transcription-translationand translation-messenger decay chondrocytes, 1989 coupling:Separate mechanisms for differentmessengers, 1126 Nitrofurans Nucleoside phosphorothioate Nitrofurans, a group of synthetic antibiotics, with a new mode of action: Platinumbinds selectivelyto phosphorothioategroups in mono- and Discrimination of specific messenger RNA classes, 3386 polynucleotides:General method for heavy metal staining of specific Nitrogenase nucleotides,2536 Interactions of heterologous nitrogenase components that generate Nucleosome catalytically inactive complexes, 4369 Histones H3 and H4 interactwith the ends of nucleosomeDNA, 4400 Nitrogen fixation Linkingnumbers and nucleosomes,2639 Hydrogen evolution affects efficiency of nitrogen fixation in nodulated Nucleaselimit digestionpattern of chromatin,3391 symbionts, 1207 Selective digestionof transcriptionallyactive ovalbumingenes from Nitrogen metabolism oviduct nuclei, 3966 Metabolic indicator of photoperiodic timing, 501 Variabilityin DNA repeat length in chromatinof highereukaryotes, Nonisotropic dilation 4382 Maximal functions: Homogeneous curves, 2176 Nucleosynthesis Nonlinearpartial differential equation Allende meteorite: Isotopically anomalous xenon is accompanied by Delayed singularity formation for solutions of nonlinear partial normal osmium, 4253 differential equations in higher dimensions, 281 Nucleotidebinding Nonlinear wave propagation Transitory tight binding of ATP and of committed Pi and ADP during Delayed singularity formation for solutions of nonlinear partial ATP synthesis by chloroplasts, 4314 differential equations in higher dimensions, 281 Nucleotide,mercurated Nonsuppressibleinsulin-like activity Transcription in vitro of chromatin in presence of mercurated Amino-terminal sequencesof two polypeptides from human serum with nucleotide, 1564 nonsuppressible insulin-like and cell-growth-promoting activities: Transcription in vitro of immunoglobulin kappa light chain genes in Structural homology with insulin B chain, 4379 isolated mouse myeloma nuclei and chromatin, 775 Norepinephrine Nucleotide,methylated Catecholamine-stimulated cyclic GMP accumulation in rat pineal: Inhibition of initiation of protein synthesis by Downloaded by guest on October 5, 2021 4760 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

7-methylguanosine-5'-monophosphate, 19 Discrimination of specific messenger RNA classes, 3386 Nucleotide,regulatory , lac Control of development: Role of regulatory nucleotides synthesized by Plasmid cloning vehicle allowing regulated expression of eukaryotic DNA membranes of Bacillus subtilis in initiation of sporulation, 331 in bacteria, 3900 Nucleotide sequence Operon, tra see also Deoxyribonucleic acid sequence Molecular cloning of DNA from F sex factor of Escherichia coli K-12, 64 Deletions of lambda phage locating a prm mutation within rightward Operon, trp operator, 712 Nitrofurans, a group of synthetic antibiotics, with a new mode of action: Envelope-specific and sarcoma-specific nucleotide sequences from Discrimination of specific messenger RNA classes, 3386 different parents in RNAs of avian tumor virus recombinants, 1073 Nucleotide sequence of region preceding trp mRNA initiation site and Influenza virus genome consists of eight distinct RNA species, 3045 role in promoter and operator function, 2351 Nucleotide sequence of region preceding trp mRNA initiation site and Opiate role in promoter and operator function, 2351 see Endorphin: Enkephalin; Morphine; Receptor, opiate Nucleotide sequences beyond sites of transcriptional termination, 717 Isolation, primary structure, and synthesis of a-endorphin and Nucleotide sequences in mouse DNA and RNA specific for Moloney -y-endorphin, two peptides of hypothalamic-hypophysial origin with sarcoma virus, 3705 morphinomimetic activity, 3942 Nucleotide,signal Opiate and stimulus-produced analgesia: Functional anatomy of Diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) in mammalian cells in medullospinal pathway, 4685 levels varying widely with proliferative activity of tissue: Possible Opiate receptor: Model explaining structure-activity relationships of positive "pleiotypic activator", 3984 opiate agonists and antagonists, 4215 Nucleotide,tetra- Opiate activity Ethidium bromide-(dC-dG-dC-dG)2 complex in solution: Intercalation Tolerance and dependence evoked by endogenous opiate peptide, 3165 and sequence specificity of drug binding at tetranucleotide duplex Untriakontapeptide with opiate activity from camel pituitary glands, level, 3343 1145 Nucleus Opiate-like peptide Binding of insulin to isolated nuclei, 1427 (3-Endorphin is a potent analgesic agent, 2895 Nucleus-membrane interaction in capping of surface membrane Preliminary analysis of 1H and '3C spectral and relaxation behavior in receptor-. 4.560 methionine-enkephalin, 2589 S. in!lmi:, i . )f iii-1 ;.ir proteins during DNA repair synthesis in human Opioid activity ?)i1i,i! lil)lr,lbim,i-Idamaged with ultraviolet radiation or Opioid activity of a peptide, (-lipotropin-(61-91), derived from N-acetoxy-2-acetylaminofluorene, 1466 3-lipotropin, 1821 Nucleus raphe magnus Optical rotation Opiate and stimulus-produced analgesia: Functional anatomy of Double-stranded polynucleotides: Possible conformation, 2959 medullospinal pathway, 4685 Optic nerve Nutrition Enhanced labeling of retinal protein during regeneration of optic nerve see also Diet; Trace metal nutrition; Trace nutrient in goldfish, 828 Amino acids and control of nucleolar size, the activity of RNA Organic mercurials Polymerase I, and DNA synthesis in liver, 3201 Affinity purification of synthetic peptides, 3160 Control of cell division in Saccharomyces cerevisiae by methionyl-tRNA, Maturation (meiosis) in small Xenopus laevis oocytes induced by 1664 injection of maturation promoting factor, 2028 Diet: Influence on survival of mice, 1279 Ornithine carbamoyltransferase (EC 2.1.3.3) Interactions between nutritional factors and drug biotransformations in Abnormal ornithine carbamoyltransferase in mice having sparse-fur man, 2501 mutation, 1693 Kinetics of glucagon in man: Effects of starvation, 1735 Ornithine decarboxylase (EC 4.1.1.17) Selenium: Essential trace nutrient for growth of WI-38 diploid human Activation of 3':5'-cyclic AMP-dependent protein kinase and induction fibroblasts, 2023 of ornithine decarboxylase as early events in induction of mixed-function oxygenases, 1241 Biphasic stimulation of polyamine biosynthesis in primary mouse kidney Ocular dominance column cells by infection with polyoma virus: Uncoupling from DNA and Metabolic mapping of primary visual system of monkey by rRNA synthesis, 4022 autoradiographic [14C]deoxyglucose technique, 4230 Human somatotropin: Biological characterization of recombinant Olefaction molecule, 3463 dunce, a mutant of Drosophila deficient in learning, 1684 (V-Methylornithine, potent competitive inhibitor of ornithine Oligonucleotide synthesis decarboxylase, blocks proliferation of rat hepatoma cells in culture, Chemical and enzymatic synthesis of lactose operator of Escherichia coli 1626 and its binding to lactose repressor, 91 Protein inhibitor to ornithine decarboxylase induced by end products of Oncogenesis its reaction, 1858 Prevention of spontaneous leukemia in AKR mice by type-specific Regulation of ornithine decarboxylase activity by guanine nucleotides: In immunosuppression of endogenous ecotropic virogenes, 4633 vivo test in potassium-depleted Escherichia coli, 3502 Oncornavirus Ornithine, a-methyl- Fucose-deficient glycoprotein precursor to Rauscher leukemia virus o-Methylornithine, potent competitive inhibitor of ornithine gp69/71, 2326 decarboxylase, blocks proliferation of rat hepatoma cells in culture, Independent regulation of endogenous and exogenous avian RNA tumor 1626 virus genes, 2259 Osmium Oncornavirus-like particle Allende meteorite: Isotopically anomalous xenon is accompanied by Simultaneous detection of reverse transcriptase and high molecular normal osmium, 4253 weight RNA in tissue of patients with Hodgkin's disease and in human Metal cluster in catalysis: Hydrocarbon reactions, 4274 patients with leukemia, 4649 Solar abundance of osmium, 1382 One-center integrals Osmoregulation Magnetic circular dichroism of molecules in dense media: Spin-forbidden Eel esophagus as osmoregulatory organ, 1348 transitions of carbonyl molecules, 2964 Ovary Oocyte, starfish Immunological block to mammalian fertilization: Survival and organ Hormonal control of meiosis: Specificity of 1-methyladenine receptors in distribution of immunoglobulin which inhibits fertilization in vivo, starfish oocytes, 1669 2405 Oocyte, Xenopus laevis . Oviduct nucleus DNA-relaxing activity and endonuclease activity in Xenopus laevis Selective digestion of transcriptionally active ovalbumin genes from oocytes, 4551 oviduct nuclei, 3966 Localization by in situ hybridization of amplified ribosomal DNA during Oxidative metabolism Xenopus laevis oocyte maturation (light and electron microscopy Relation between oxidative metabolism and slow rhythmic potentials in study), 833 mammalian intestinal muscle, 4239 Maturation (meiosis) in small Xenopus laevis oocytes induced by Oxidative phosphorylation injection of maturation promoting factor, 2028 Restoration of oxidative phosphorylation by purified Operator N,N'-dicyclohexylcarbodiimide-sensitive latent Construction and propagation of defective simian virus 40 genome adenosinetriphosphatase from Mycobacterium phlei, 3050 bearing operator from bacteriophage X, 1068 Steady-state kinetic formalism applied to multienzyme complexes, Isolation of hybrid lac made in vitro between normal lac oxidative phosphorylation, and interacting enzymes, 4432 repressor and its homogeneous tryptic core, 3103 Stoichiometric relationship between energy-dependent proton ejection Operator, lac and electron transport in mitochondria, 437 Chemical and enzymatic synthesis of lactose operator of Escherichia coli Oxygenation, cooperative and its binding to lactose repressor, 91 Structure-function relations in hemoglobin as determined by x-ray Operon absorption spectroscopy, 491 Construction of plasmids carrying the cI gene of bacteriophage A, 4174 Oxygen binding Operon, L-arabinose Nature of 02 and CO binding to metalloporphyrins and heme proteins, L-Arabinose operon: Electron microscopy of gene regulation, 1518 3333 Operon, gal Soluble dextran-hemoglobin complex: Potential blood substitute, 2128 Conditional lethal mutants of Escherichia coli defective in transcription Oxygen evolution termination factor rho, 1959 Proton relaxation and charge accumulation during oxygen evolution in Nitrofurans, a group of synthetic antibiotics, with a new mode of action: photosynthesis, 1196 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4761

Oxypressin Mutant of Escherichia coli with altered elongation factor Tu, 1698 Third amino acid residue of oxytocin is important for action on isolated Simian virus 40 tumor-specific proteins in nucleus and plasma rat uterus: Relationship between hormone conformation and activity, membrane of HeLa cells infected by adenovirus 2-SV40 hybrid virus 3054 Ad2+NDY2,2505 Oxytocin Peptide phosphorylation Fluorometric assay of vasopressin and oxytocin: Assay of peptides in Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic tissues, 1314 AMP-dependent protein kinase, 1038 Third amino acid residue of oxytocin is important for action on isolated Peptide protons rat uterus: Relationship between hormone conformation and activity, Nuclear magnetic resonance studies of slowly exchanging peptide 3054 protons in cytochrome c in aqueous solution, 1398 Peptides, assay of Fluorometric assay of vasopressin and oxytocin: Assay of peptides in Pactamycin tissues, 1314 Sequential translation of nonstructural proteins in cells infected with Peptide synthesis Semliki Forest virus mutant, 1936 Antiviral effect on MS-2 coliphage obtained with synthetic antigen, 4636 Pancreas Crystalline semisynthetic ribonuclease-S', 1844 Elevated serum ribonuclease in patients with pancreatic cancer, 2308 Hydrolysis and transpeptidation of peptide substrates by acetyl-pepsin, Survival of fetal rat pancreases frozen to -78 and -196?, 4105 3915 Pancreatic secretion Solid phase synthesis of protein activator for lecithin-cholesterol Cellular cyclic nucleotides and enzyme secretion in pancreatic acinar cell, acyltransferase corresponding to human plasma apoC-I, 1422 156 Peptide, synthetic Papain cleavage site Affinity purification of synthetic peptides, 3160 Papain cleavage site of H-2 glycoproteins, 915 Enzymatic NH2-terminal acetylation of proteins with Paralysis des-NAl-acetyl-a-melanotropin as substrate, 3010 Neurophysiological defects in temperature-sensitive paralytic mutants of Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic Drosophila melanogaster, 3253 AMP-dependent protein kinase, 1038 Paramecium aurelia Peptidoglycan Amphipathic amines affect membrane excitability in Paramecium Oligomeric intermediate in peptidoglycan biosynthesis in Bacillus aurelia: Role for bilayer couple, 452 megaterium, 4200 Paramyosin Peptidyltransferase (EC 2.3.2.12) Myosin-paramyosin cofilaments: Enzymatic interactions with F-actin, Role of 5S RNA in assembly and function of 50S subunit from 3015 Escherichia coli, 2221 Parasite, intracellular Perinatal development Phagosome-lysosome fusion in cultured macrophages prevented by Changes in levels of cellular retinol- and retinoic-acid-binding proteins of sulfatides of Mycobacterium tuberculosis, 2510 liver and lung during perinatal development of rat, 3976 Parietal eye of lizard Periodate oxidation Parietal eye of lizard: Neuronal photoresponses and feedback from Assay of ribonuclease H, endoribonucleases, and phosphatases, 1556 pineal gland, 654 Assay of ribonuclease H, endoribonucleases, and phosphatases Partial retention of diatomic differential overlap (correction), 4711 Molecular orbital studies of enzyme activity: Catalytic mechanism of Periplaneta americana serine proteinases, 432 Chemo-anemotaxis: Behavioral response to sex pheromone in nonflying Pathology insects, 2524 Aryl 4-monooxygenase and cytochrome P-450 in aorta: Role in Peroxidase atherosclerosis, 3723 Peroxidase complex with concomitant anodal and cathodal variation in Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced red-fruited tomato species, 900 abnormality of connective tissue, 2909 Peroxisome Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced Fatty acyl-CoA oxidizing system in rat liver peroxisomes: Enhancement abnormality of connective tissue (correction), 4247 by clofibrate, a hypolipidemic drug, 2043 Hypertrophy and hyperplasia of somatostatin-containing D-cells in Pertechnetate diabetes, 1338 Structural characterization of bridged 99Tc-Sn-dimethylglyoxime Mouse amyloid protein AA: Homology with nonimmunoglobulin protein complex: Chemistry of 99mTc-radiopharmaceuticals prepared by Sn(II) of human and monkey amyloid substance, 964 reduction of pertechnetate, 4287 Phagosome-lysosome fusion in cultured macrophages prevented by Pesticide residue sulfatides of Mycobacterium tuberculosis, 2510 Screening by negative chemical ionization mass spectrometry for Vitamin A-containing lipocytes and formation of type III collagen in environmental contamination with toxic residues: Application to liver injury, 3719 human urines, 1777 Penicillin Phagocyte Induction of immunological tolerance to major antigenic determinant of Role of peptidase in phagocyte chemotaxis, 2439 penicillin: Therapeutic approach to penicillin allergy, 2091 Phagocytosis Suppression of lytic effect of beta lactams on Escherichia coli and other Collagenase and prostaglandins produced by isolated adherent bacteria, 3293 rheumatoid synovial cells, 945 Penicillinase (EC 3.5.2.6) Phagosome Catalytic reaction of penicillinase: Acquisition of substrate-specific Phagosome-lysosome fusion in cultured macrophages prevented by parameters, 1048 sulfatides of Mycobacterium tuberculosis, 2510 Membrane penicillinase of Bacillus licheniformis 749/C: Sequence and Phase diagram possible repeated tetrapeptide structure of phospholipopeptide region, Subcellular localization of S-adenosyl-L-methionine:tRNA 1457 methyltransferases with aminoacyl-tRNA synthetases in human and Penicillin-binding component mouse: Normal and leukemic leukocytes, 3862 Altered penicillin-binding components in penicillin-resistant mutants of Phaseolus aureus, Roxb. Bacillus subtilis, 1816 Reserve protein metabolism in cotyledons of mung bean seedlings, 3168 Penicillin-resistant mutants Phase transition Altered penicillin-binding components in penicillin-resistant mutants of Erythrocyte phosphate transport inhibited by high pressures, 2767 Bacillus subtilis, 1816 Subcellular localization of S-adenosyl-L-methionine:tRNA Pentachlorophenol methyltransferases with aminoacyl-tRNA synthetases in human and Screening by negative chemical ionization mass spectrometry for mouse: Normal and leukemic leukocytes, 3862 environmental contamination with toxic residues: Application to van der Waals-type equation of state for fluids with associating human urines, 1777 molecules, 1773 Pepsin, acetyl- Pheasant virus Hydrolysis and transpeptidation of peptide substrates by acetyl-pepsin, Pheasant virus: New class of ribodeoxyvirus, 1333 3915 Phenobarbital Peptidase Activation of 3':5'-cyclic AMP-dependent protein kinase and induction Role of peptidase in phagocyte chemotaxis, 2439 of ornithine decarboxylase as early events in induction of Peptide bond, cis- and trans- mixed-function oxygenases, 1241 Conformation of uncomplexed [Phe4,Val6]antamanide crystallized from Phenylalanine ammonia-lyase (EC 4.3.1.5) nonpolar solvents, 1782 Phytochrome-mediated de novo synthesis of phenylalanine Peptide, cyclic ammonia-lyase: An approach using pre-induced mustard seedlings, Conformation of uncomplexed [Phe4,Val6]antamanide crystallized from 4017 nonpolar solvents, 1782 Phenylalanine 4-monooxygenase (EC 1.14.16.1) Peptide, N-formylmethionyl Hepatic phenylalanine 4-monooxygenase is a phosphoprotein, 159i Role of peptidase in phagocyte chemotaxis, 2439 Pheromone Peptide isolation Chemo-anemotaxis: Behavioral response to sex pheromone in nonflying Targeted attachment of peptides and proteins to solid supports, 3516 insects, 2524 Peptide mapping Chromosomal gene required for killer plasmid expression, mating, and see also Amino-acid sequence spore maturation in Saccharomyces cerevisiae, 2061 Clathrin: Protein associated with intracellular transfer of membrane by Multiple pheromone system controlling mating in Drosophila coated vesicles, 1255 melanogaster, 591 Human liver and placental alkaline phosphatase isoenzymes are coded Phormia regina by different genes, 2201 Anesthetic stimulation of insect water receptors, 3315 Downloaded by guest on October 5, 2021 4762 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Phosgene. Photolabile molecule 2-Diazo-3,3,3-trifluoropropionyl chloride: Reagent for photoaffinity Rapid-flow resonance Raman spectroscopy of photolabile molecules: labeling, 1406 Rhodopsin and isorhodopsin, I Phosphatase Photomorphogenesis Assay of ribonuclease H, endoribonucleases, and phosphatases, 1556 Localization of phytochrome in etioplasts and its regulation in vitro of Assay of ribonuclease H, endoribonucleases, and phosphatases gibberellin levels, 138 (correction), 4711 Photophosphorylation Phosphate ion Chloroplast coupling factor 1: Species-specific receptor for tentoxin, 2245 Insulin release and phosphate ion efflux from rat pancreatic islets Redox titration of fluorescence yield of photosystem II, 2211 induced by L-leucine and its nonmetabolizable analogue, Photoprotection 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid, 3403 Photoprotection by carotenoid pigments in copepod Diaptomus Phosphatidylcholine nevadensis, 971 Inner and outer hydrocarbon chains of lipid bilayer vesicles: Direct Photoreceptor pigment spectroscopic observation, 2716 Photoreceptor pigment that induces differentiation in slime mold Phosphatidylserine Physarum polycephalum, 3896 Membrane penicillinase of Bacillus licheniformis 749/C: Sequence and Photosynthesis possible repeated tetrapeptide structure of phospholipopeptide region, Covalently linked chlorophyll a dimer: Biomimetic model of special pair 1457 chlorophyll, 4282 Phosphodiesterase Efficiency of energy transfer from photosystem II to photosystem I in see also 3':5'-Cyclic-nucleotide phosphodiesterase Porphyridium cruentum, 3957 Assay of ribonuclease H, endoribonucleases, and phosphatases, 1556 "Energy upconversion" theory for green plant photosynthesis, 2773 Assay of ribonuclease H, endoribonucleases, and phosphatases Path of electrons in photosynthesis, 4502 (correction), 4711 Proton relaxation and charge accumulation during oxygen evolution in Phosphoenolpyruvate pl ,osynthesis, 1196 3-Phosphohistidine isolated from phosphorylated pyruvate, phosphate Redox titration of fluorescence yield of photosystem II, 2211 Idikinase, 4415 Structure of special-pair chlorophyll, 1791 Phosphoglycerate kinase (EC 2.7.2.3) Temperature dependence of cycloheximide-sensitive phase of circadian Cibacron blue F3GA binds to proteins containing dinucleotide fold, 361 cycle in Acetabularia mediterranea, 3216 Phospholipase A2 (EC 3.1.1.4) Photosynthetic bacteria /3-Bungarotoxin, pre-synaptic toxin with enzymatic activity, 178 Primary structure of two cytochromes c,2:Close similarity to functionally Phospholipid unrelated mitochondrial cytochrome c, 472 Activation of long chain fatty acids with acyl carrier protein: New Photosynthetic unit enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli, 4374 Photosynthetic unit in lettuce, 4560 Adenylate cyclase activity in LM cells by modified manipulation of Photosystem I membrane phospholipid composition in vivo, 4482 Efficiency of energy transfer from photosystem II to photosystem I in Alterations in cell surface glycosphingolipids and other lipid classes of Porphyridium cruentum, 3957 fibroblasts in familial hypercholesterolemia, 4339 Photosystem II Incorporation of fatty acids containing photosensitive groups into Biliproteins of cyanobacteria and Rhodophyta: Homologous family of phospholipids of Escherichia coli, 86 photosynthetic accessory piF-1.,lt;. l^ Inhibition of arachidonic acid release from cells as biochemical action of Efficiency of energy transfel I i:. I::,!-..-i -.': II to photosystem I in anti-inflammatory corticosteroids, 1730 Porphyridium cruentum, 3957 I,ipid vesicles as carriers for introducing materials into cultured cells: Redox titration of fluorescence yield of photosystem II, 2211 Influence of vesicle lipid composition on mechanism(s) of vesicle Phycobilin incorporation into cells, 1603 Efficiency of energy transfer from photosystem II to photosystem I in Modulation of membrane fluidity: Homogeneous catalytic hydrogenation Porphyridium cruentum, 3957 of phospholipids and phospholipid-water model biomembranes, 3971 Phycoerythrin Solid phase synthesis of protein activator for lecithin-cholesterol Efficiency of energy transfer from photosystem II to photosystem I in acyltransferase corresponding to human plasma apoC-I, 1422 Porphyridium cruentum, 3957 Transbilayer distribution and movement of cholesterol and phospholipid Phycomyces in membrane of influenza virus, 391 Responses of Phycomyces indicating optical excitation of lowest triplet Phospholipopeptide state of riboflavin, 1969 Membrane penicillinase of Bacillus licheniformis 749/C: Sequence and Phylloquinone possible repeated tetrapeptide structure of phospholipopeptide region, m-Carboxyglutamic acid-containing protein from bone, 1447 1457 -y-Carboxyglutamic acid-containing protein from bovine bone: Primary Phosphonoacetic acid structure, 3374 Differential effect of phosphonoacetic acid on expression of Vitamin K-dr.-cndcrn- ^.:n:ho':^ and modification of precursor Epstein-Barr viral antigens and virus production, 1745 prothrom !-:m ' - i. r,-' II .. hepatoma cells, 2803 Phosphopantetheine Physarum polycephalum Klebsiella aerogenes citrate (pro-3S)-lyase: Structure of prosthetic Photoreceptor pigment that induces differentiation in slime mold group, 1872 Physarum polycephalum, 3896 Phosphoribosylamine synthesis Physics Purine auxotroph deficient in phosphoribosylpyrophosphate see also Applied physical sciences amidotransferase and phosphoribosylpyrophosphate aminotransferase Conductivity and structure of bilinear organic addition compounds, 3820 activities with normal activity of ribose-5-phosphate aminotransferase, I)eep inelastic scattering of charged leptons, 3816 2458 Deep inelastic scattering of leptons, 3351 Phosphoribosylpyrophosphate amidotransferase Extended x-ray-absorption fine structure-Auger process for surface see Amidophosphoribosyltransferase structure analysis: Proposed experiment, 2550 Phosphoribosylpyrophosphate aminotransferase Inertial frame. and Lorentz transformation, 1418 Purine auxotroph deficient in phosphoribosylpyrophosphate Interacting quantum fields and chronometric principle, 3355 amidotransferase and phosphoribosylpyrophosphate aminotransferase Kinetic theory and ergodic properties, 1802 activities with normal activity of ribose-5-phosphate aminotransferase, Lifetime-width relation for a decaying state and the uncertainty 2458 principle, 283 Phosphorylase (EC 2.4.1.1) Moment equation description of magnetic reversals in the earth, 4297 1,N6-Etheno-AMP and 1,N6-etheno-2'-deoxy-AMP as probes of activator Relativistic spherical vortex (correction), 2527 site of glycogen phosphorylase from rabbit skeletal muscle, 2696 Stringent factor from Escherichia coli directs ribosomal binding and Phosphorylcholine release of uncharged tRNA, 687 Attempts to locate residues in complementarity-determining regions of Viscosity of dilute gases and vapors, 4302 antibody combining sites that make contact with antigen, 617 Physiology Human and murine phosphorylcholine-binding immunoglobulins: Apolipoproteins in rat serum and renal lymph, 1757 Conserved subgroup and first hypervariable region of heavy chains, Circadian organization of estrous cycle of golden hamster, 2923 2096 (vt,^.rchit-cptric mapping by microdensitometry, 2928 Size differences among immunoglobulin heavy chains from I )<,1:.. l:.. l it itidei from human growth hormone: Partial purification phosphorylcholine-binding proteins, 2109 from peptic digest and long-term action in ob/ob mice, 4706 Phosphorylcholine, 1,2-dihexadecyl-sn-glycero-3- Direct determination of surface tension in lung, 4698 Nuclear magnetic resonance studies of interaction of general anesthetics Ear and hearing in Sphenodon punctatus, 4244 with 1,2-dihexadecyl-sn-glycero-3-phosphorylcholine bilayer, 3999 Effects of cholera toxin on cochlear endolymph production: Model for Photoaffinity labeling endolymphatic hydrops, 1761 2-Diazo-3,3,3-trifluoropropionyl chloride: Reagent for photoaffinity Effects of deuterium oxide on mechano-sensory receptor, 4703 labeling, 1406 Effects of persistent selective suppression of ganglionic Monovalent derivatives of concanavalin A, 790 butyrylcholinesterase on steady stner :.rd r.::e..^cra.^t-llevels of Photoaffinity labeling and quaternary structure of acetylcholine receptor acetylcholinesterase: Function of :) :l '.'.-: -ii:i -'i* ' and regulation from Torpedo californica, 2624 of protein synthesis, 2936 Photoaffinity site-specific covalent labeling of human Evoked neurotransmitter release: Statistical effects of nonuniformity and corticosteroid-binding globulin, 4462 nonstationarity, 2913 Photobleaching recovery Evoked neurotransmitter release: Statistical effects of nonuniformity and Lateral transport on cell membranes: Mobility of concanavalin A nonstationarity (correction), 3320 receptors on myoblasts, 2409 Force-velocity characteristics for calcium-activated mammalian slow-twitch and fast-twitch skeletal fibers from the guinea pig, 4693 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4763

Intraneuronal guanylyl-imidodiphosphate injection mimics long-term Escherichia coli plasmids, 2316 synaptic hyperpolarization in Aplysia, 4689 Plasmid, colicin El Ion distribution in subcellular myocardial particulates separated by Amplification in Escherichia coli of enzymes involved in genetic density gradient centrifugation with nonpolar liquid under ion recombination: Construction of hybrid ColEl plasmids carrying immobilization conditions, 1754 structural gene for exonuclease I, 3492 Localization and specificity of binding of subprimate placental lactogen Biochemical construction of specific chimeric plasmids from ColEl DNA in rabbit tissues, 2932 and unfractionated Escherichia coli DNA, 3838 Morphine-like peptides in mammalian brain: Isolation, structure Colicin E2 is a DNA endonuclease, 3989 elucidation, and interactions with opiate-receptor, 2515 Mechanism of genetic recombination: Electron microscopic observation Morphine-like peptides in mammalian brain: Isolation, structure of recombination intermediates, 3000 elucidation, and interactions with opiate receptor (correction), 4247 Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by Morphinomimetic activity of synthetic fragments of (-lipotropin and DNA gyrase, 4474 analogs, 3308 Specialized transduction of colicin El DNA in Escherichia coli K-12 by Multiple factor analysis of action of local anesthetics, 3726 phage lambda, 3238 Opiate receptor: Autoradiographic localization in rat brain, 3729 Plasmid F Oscillatory neuronal circuit generating locomotory rhythm, 3734 Molecular cloning of DNA from F sex factor of Escherichia coli K-12, 64 Presynaptic calcium currents and relation to synaptic transmission: Plasmid, F' Voltage clamp study in squid giant synapse and theoretical model for F prime factors able to replicate in Escherichia coli Hfr strains, 198 calcium gate, 2918 Plasmid, hybrid Prevention and suppression by azathioprine of venom-induced Biochemical construction of specific chimeric plasmids from ColEl DNA protein-losing gastropathy in dogs, 968 and unfractionated Escherichia coli DNA, 3838 Relation between oxidative metabolism and slow rhythmic potentials in Cloning of Escherichia coli DNA that controls cell division and capsular mammalian intestinal muscle, 4239 polysaccharide synthesis, 697 Renal CO2 production from glutamine and lactate as function of arterial Expression of thymidylate synthetase gene of Bacillus subtilis perfusion pressure in dog, 4235 bacteriophage Phi-3-T in Escherichia coli, 4145 Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells, 2520 Plasmid cloning vehicle allowing regulated expression of eukaryotic DNA Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells in bacteria, 3900 (correction), 4247 Plasmid, killer Phytochrome Chromosomal gene required for killer plasmid expression, mating, and Localization of phytochrome in etioplasts and its regulation in vitro of spore maturation in Saccharomyces cerevisiae, 2061 gibberellin levels, 138 Plasmid pCR1 Phytochrome-mediated de novo synthesis of phenylalanine Characterization of 2-,um DNA of Saccharomyces cerevisiae by ammonia-lyase: An approach using pre-induced mustard seedlings, restriction fragment analysis and integration in an Escherichia coli 4017 plasmid, 2072 Phytohemagglutinin Plasmid pML21 Intracellular precursor to DNA excreted by human lymphocytes, 3211 Molecular cloning of DNA fragments produced by restriction Regulation of induction of T and B cell colonies in vitro by normal endonucleases SalIl and BamI, 1537 human lymphocytes, 4546 Plasmid pSC101 Variations of DNA polymerases-a and -( during prolonged stimulation Molecular cloning of DNA fragments produced by restriction of human lymphocytes, 785 endonucleases SalIl and BamI, 1537 Phytomitogen Plasmid, R222 Human alpha-fetoprotein as modulator of human lymphocyte Synthesis of R plasmid protein associated with tetracycline resistance is transformation: Correlation of biological potency with electrophoretic negatively regulated, 1509 variants, 4645 Plasminogen activator Inhibitory effect of human alpha-fetoprotein on in vitro transformation Rous-sarcoma-virus-transformed fibroblasts having low levels of of human lymphocytes, 2857 plasminogen activator, 3613 Phytotoxin Plastocyanin Chloroplast coupling factor 1: Species-specific receptor for tentoxin, 2245 Blue copper centers in proteins, spectroscopic studies and structural Pili, F model, 1389 Molecular cloning of DNA from F sex factor of Escherichia coli K-12, 64 Platelet Pineal gland Antagonism of 5-hydroxykynurenamine against serotonin action on Catecholamine-stimulated cyclic GMP accumulation in rat pineal: platelet aggregation, 643 Apparent presynaptic site of action, 3398 Ca2+ and adenylate and guanylate cyclases in control of platelet Parietal eye of lizard: Neuronal photoresponses and feedback from secretion and aggregation, 1829 pineal gland, 654 Multiple active forms of thrombin: Binding to platelets and effects on Pinocytosis platelet function, 1660 Specific recognition sites mediating clearance of lysosomal enzymes in Platinum vivo, 4045 Platinum binds selectively to phosphorothioate groups in mono- and Pituitary gland polynucleotides: General method for heavy metal staining of specific see also Cell culture, pituitary nucleotides, 2536 Fluorometric assay of vasopressin and oxytocin: Assay of peptides in Podophyllotoxin tissues, 1314 Tubulin aggregation and disaggregation: Mediation by two distinct Human pituitary growth hormone: Restoration of full biological activity vinblastine-binding sites, 2375 by noncovalent interaction of two fragments of hormone, 1476 Poisson integrals Large product of cell-free translation of messenger RNA coding for Maximal functions: Poisson integrals on symmetric spaces, 2547 corticotropin, 4319 Pokeweed mitogen i3-Lipotropin: Prohormone for morphinomimetic peptides endorphins Polyclonal activation of bone-marrow-derived lymphocytes from human and enkephalins, 2156 peripheral blood measured by direct plaque-forming cell assay, 3676 Obligatory role of hypophysis in sexual differentiation of hepatic Regulation of induction of T and B cell colonies in vitro by normal metabolism in rats, 1462 human lymphocytes, 4546 Untriakontapeptide with opiate activity from camel pituitary glands, Polarity suppressor mutant 1145 Conditional lethal mutants of Escherichia coli defective in transcription Placental lactogen termination factor rho, 1959 Localization and specificity of binding of subprimate placental lactogen Polarization in rabbit tissues, 2932 Application of polarization effects in light scattering, 486 mRNA-dependent synthesis of authentic precursor to human placental Deep inelastic scattering of charged leptons, 3816 lactogen: Conversion to mature hormone form in ascites cell-free Poliovirus extracts, 1179 Anticomplementary nature of smaller DNA produced during synthesis of Plant disease extensive DNA copies of poliovirus RNA, 3408 Serinol as an activator of toxin production in attenuated cultures of DNA copies of poliovirus RNA synthesized in high yields and at high Helminthosporium sacchari, 4007 specific activities, 2191 Plants 5' End of poliovirus mRNA is not capped with m7G(5')ppp(5')Np, 375 Cell recognition in plants: Determinants of stigma surface and pollen Poliovirus-induced inhibition of polypeptide initiation in vitro on native interactions, 2788 polyribosomes, 1834 Plasma, defibrinogenated 5'-Terminal structure of poliovirus polyribosomal RNA is pUp, 327 Proliferation of Rous sarcoma virus-infected, but not of normal, chicken Pollen fibroblasts in oxygen-enriched environment, 1265 Cell recognition in plants: Determinants of stigma surface and pollen Plasma, diffuse interactions, 2788 Equilibrium and stability code for a diffuse plasma, 984 Pollination Plasma expander Cell recognition in plants: Determinants of stigma surface and pollen Soluble dextran-hemoglobin complex: Potential blood substitute, 2128 interactions, 2788 Plasma, human Polyacrylamide Prekallikrein and high-molecular-weight kininogen: A complex in human Immunogenicity: Immunon model of immune response, 3671 plasma, 4179 Immunogenicity: Immunon model of immune response (correction), 4247 Plasmid Polyadenylate see also Episome Intracellular site of synthesis and localization of leghemoglobin in root Construction of plasmids carrying the cI gene of bacteriophage A, 4174 nodules, 3843 Isolation of inverted repeat sequences, including IS1, IS2, and IS3, in Downloaded by guest on October 5, 2021 4764 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Large product of cell-free translation of messenger RNA coding for Population size corticotropin, 4319 Groupselection amonglaboratory populations of Triboliumcastaneum, Mammalian messenger RNA lacking polyadenylate segment, 3088 4604 Messenger specifying sequences in DNA of chromatin subunits, 1572 Population structure mRNA sequences in nuclear 30S ribonucleoprotein subcomplexes, 2725 Multiple pheromone system controlling mating in Drosophila Short-lived methylated messenger RNA in mouse kidney, 2609 melanogaster, 591 Polyamine Rates of evolution in seed plants: Net increase in diversity of Activation of 3':5'-cyclic AMP-dependent protein kinase and induction chromosome numbers and species numbers through time, 2086 of ornithine decarboxylase as early events in induction of Population variation mixed-function oxygenases, 1241 Darwin'sfinches: Population variation and naturalselection, 257 Biphasic stimulation of polyamine biosynthesis in primary mouse kidney Porphyria cells by infection with polyoma virus: Uncoupling from DNA and see also Protocoproporphyria; Uroisocoproporphyria rRNA synthesis, 4022 Porphyria cutanea tarda Polyamine Schiff base Porphyria variegata and porphyria cutanea tarda in siblings: Chemical Covalent modification of proteins by metabolites of NAD+, 3131 and genetic aspects (Addendum), 1323 Polyatomic molecule Porphyria, hepatic Viscosity of dilute gases and vapors, 4302 Cobalt inhibition of synthesis and induction of 1-aminolevulinate Polycation synthase in liver, 1499 Polycation-induced assembly of purified tubulin, 2813 Porphyria variegata Polycytidylate Porphyria variegata and porphyria cutanea tarda in siblings: Chemical Messenger RNA competition in shutoff of human interferon production, and genetic aspects (Addendum),1323 1621 Porphyridium cruentum Poly(dA-dT) Efficiency of energy transfer from photosystem II to photosystem I in Nuclear magnetic resonance studies of helix-coil transition of Porphyridium cruentum, 3957 poly(dA-dT) in aqueous solution, 674 Post-translational modification Polydeoxyribonucleotide synthetase (ATP) (EC 6.5.1.1) Modifications of purified glucose-6-phosphate dehydrogenase and other Biochemical construction of specific chimeric plasmids from ColEl DNA enzymes by a factor of low molecular weight abundant in some and unfractionated Escherichia coli DNA, 3838 leukemiccells, 77 Polyguanylate Potassium Enzyme catalyzed covalent binding of benzo[a]pyrene to poly(G), 1117 Mullercell functionduring spreading depression in frog retina, 1351 Hydrocarbon structure in enzyme-catalyzed benzo[a]pyrene-poly(G) Potassiumionophore (valinomycin) inhibits lymphocyteproliferation by covalent complex, 1437 its effects on cell membrane, 3599 Structure of 7,12-dimethylbenz[a]anthracene-guanosine adducts, 2311 Regulation of ornithine decarboxylase activity by guanine nucleotides: In Polyinosine vivo test in potassium-depleted Escherichia coli, 3502 Messenger RNA competition in shutoff of human interferon production, Temperature dependence of four ionic processes of spike electrogenesis 1621 in eel electroplaques, 3554 Polymerization Potato spindle tuber viroid Calorimetric studies of in vitro polymerization of brain tubulin, 3565 Hybridization of potato spindle tuber viroid to cellular DNA of normal Polymer, soft plants, 2453 Soft polymers: Time-dependent response in moderately large Potato tuber deformations, 981 Homologous inhibitors from potato tubers of serine endopeptidases and Polymorphism metallocarboxypeptidases, 1941 Selective cannibalism in rotifer Asplanchna sieboldi: Contact recognition Precambrian microfossil of morphotype and clone, 3233 Fossil microorganisms from 2800 to 2500 million-year-old Bulawayan Polymyxin B stromatolite: Ultramicrochemical analyses, 2973 Freeze-fracture study of mast cell secretion, 2823 Predation Polynucleotide, double-stranded Ploy and counterploy in predator-prey interactions: Orb-weaving spiders Double-stranded polynucleotides: Possible conformation, 2959 versus bombardier beetles, 1365 Polynucleotide secondary structure Predator-prey relationship Polynucleotide secondary structure altered by ribosomal protein Si, 1824 Evolution, population dynamics, and stability, 665 Polyoma virus Selective cannibalism in rotifer Asplanchna sieboldi: Contact recognition Biphasic stimulation of polyamine biosynthesis in primary mouse kidney of morphotype and clone, 3233 cells by infection with polyoma virus: Uncoupling from DNA and Prekallikrein rRNA synthesis, 4022 Involvement of high molecular weight kininogen in surface-dependent Deficiency in histone acetylation in nontransforming host range mutants reactions of Hageman factor, 2554 of polyoma virus, 1092 Prekallikrein and high-molecular-weight kininogen: A complex in human Localization of gene functions in polyoma virus DNA, 4169 plasma, 4179 Mapping of three species of polyoma mRNA, 1480 Preproinsulin Mismatched base-pair regions in polyoma heteroduplex DNA: Fate Cell-free synthesis of rat preproinsulins: Characterization and partial during infection of' mouse cells, 3073 amino acid sequence, 1964 Polypeptide Partial purification and characterization of mRNA for rat preproinsulin, Synthesis of polypeptides with properties of myosin light chains directed :3539 by RNA extracted from muscle cultures, 4599 Preprothrombin Polypeptide chain initiation Vitamin K-dependent synthesis and modification of precursor Polypeptide chain initiation in eukaryotes: Initiation factor requirements prothrombin in cultured H-35 hepatoma cells, 2803 for translation of natural messengers, 44 Primate Polypeptide chain initiation in eukaryotes: Mechanism of formation of Natural antibodies in sera from healthy humans to antigens on surfaces initiation complex, 298 of type C RNA viruses and cells from primates, 2491 Polypeptide initiation Procollagen Poliovirus-induced inhibition of polypeptide initiation in vitro on native Carbohydrate moieties of procollagen: Incorporation of isotopically polyribosomes, 1834 labeled mannose and glucosamine into propeptides of procollagen Polypeptide splicing secreted by matrix-free chick embryo tendon cells, 34 In vivo splicing of protein: One continuous polypeptide from two Segment-long-spacing aggregates and isolation of COOH-terminal independently functioning operons (correction), 661 peptides from type I procollagen,4304 Polypeptide synthesis Production theory Rauscher murine leukemia virus-specific polypeptides synthesized in Homogeneous functions and extended Cobb-Douglas forms, 3747 vitro, 356 Progesterone Polyploidy ATP-PPi exchange activity of , 3443 Rates of evolution in seed plants: Net increase in diversity of Prohormone chromosome numbers and species numbers through time, 2086 (3-Lipotropin: Prohormone for morph,inomimetic peptides endorphins Polyribosome and enkephalins, 2156 see also Ribosome Opioid activity of a peptide, ,B-lipotropin-(61-91), derived from Dietary and hormonal regulation of content of acetyl coenzyme A 3-lipotropin, 1821 carboxylase-synthesizing polysomes in rat liver, 2304 Proinsulin Intracellular site of synthesis and localization of leghemoglobin in root Cell-free synthesis of rat preproinsulins: Characterization and partial nodules, 3843 amino acid sequence, 1964 Poliovirus-induced inhibition of polypeptide initiation in vitro on native Prolactin polyribosomes, 1834 Binding of insulin to isolated nuclei, 1427 Polysaccharide synthesis, capsular Human pituitary growth hormone: Restoration of full biological activity Cloning of Escherichia coli DNA that controls cell division and capsular by noncovalent interaction of two fragments of hormone, 1476 polysaccharide synthesis, 697 Localization and specificity of binding of subprimate placental lactogen Polysphondylium violaceum in rabbit tissues, 2932 Acrasin of cellular slime mold Polysphondylium violaceum, 795 Sex differences in binding of human growth hormone to isolated rat Population dynamics hepatocytes, 847 Evolution, population dynamics, and stability, 665 Proline Population genetics Proline and glycine uptake by renal brushborder membrane vesicles, Sex ratio, sex change, and natural selection, 3656 4521 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4765

Proline hydroxylation Protein, contractile Induction of human fibroblast proliferation by epidermal growth factor Myosin-mediated Ca++-regulaton of (EGF): Enhancement by EGF-binding arginine esterase and by actomyosin-adenosinetriphosphatase from porcine aorta, 2706 ascorbate, 183 Protein, covalent modification of Promoter, lac Covalent modification of proteins by metabolites of NAD+, 3131 Initiation of in vitro mRNA synthesis from the wild-type lac promoter Protein, Cro (correction), 1373 DNA-binding protein with characteristics expected for Cro protein of Properdin bacteriophage X, a repressor essential for lytic growth, 2249 Amplification convertase of complement is controlled by plasma protein Protein crystallography 31H, 3268 Applications of synchrotron radiation to protein crystallography, 128 Molecular concept of properdin pathway, 612 Protein, C-type viral p30 Prophage X Antigen related to mammalian type-C RNA viral p30 proteins is located Prophage X induction in Escherichia coli K12 envA uvrB: Sensitive test in renal glomeruli in human systemic lupus erythematosus, 233 for potential carcinogens, 3700 Protein,cytoplasmic Prophage excision Mitochondrial protein synthesis regulated by cytoplasmic proteins, 3947 Significance of constitutive integrase synthesis, 887 Protein degradation Prostaglandin Degradative rates of proteins correlated with parameter calculated from Antigen stimulation of prostaglandin synthesis and control of immune amino acid composition and subunit size, 3093 responses, 1300 Protein denaturation Antigen stimulation of prostaglandin synthesis and control of immune Conformational flexibility and protein folding: Rigid structural responses (correction), 2527 fragments connected by flexible joints in subtilisin BPN, 1974 Collagenase and prostaglandins produced by isolated adherent Protein-detergent complex rheumatoid synovial cells, 945 Molecular weight of protein moiety in protein-detergent complexes Inhibition of arachidonic acid release from cells as biochemical ack n of determined without direct knowledge of detergent binding, 4467 anti-inflammatory corticosteroids, 1730 Protein, dnaZ Prostaglandin A Mechanism of DNA elongation catalyzed by Escherichia coli DNA 15-Hydroxyprostaglandin dehydrogenase specific for prostaglandin A in polymerase III, dnaZ protein, and DNA elongation factors I and III, rabbit kidney, 1107 3511 15-Hydroxyprostaglandin dehydrogenase specific for prostaglandin A in Protein, fetal rabbit kidney (correction), 2528 see also a-Fetoprotein Prostaglandin E Fetal protein in chromatin of Novikoff hepatoma and Walker 256 Prostaglandin E synthesis in cultured human umbilical vein smooth carcinosarcoma tumors that is absent from normal and regenerating muscle cells, 1617 rat liver, 3258 Prostaglandin E1 Protein folding Adenylate cyclase activity in LM cells by modified manipulation of Conformational flexibility and protein folding: Rigid structural membrane phospholipid composition in vivo, 4482 fragments connected by flexible joints in subtilisin BPN, 1974 Ca2+ and adenylate and guanylate cyclases in control of platelet Ribonuclease A: Guanidine-unfolded state contains fast- and secretion and aggregation, 1829 slow-refolding species, 1853 Prostaglandin F2a Protein fractionation Conversion of 3T3 fibroblasts into adipose cells: Triggering of Gram-preparative protein fractionation by isotachophoresis: Human differentiation by prostaglandin F2,, and 1-methyl-3-isobutyl xanthine, growth hormone isohormones isolated, 732 4516 Protein, globular Protein, acceptor Handedness of crossover connections in ( sheets, 2619 Acceptor proteins in rat androgenic tissue chromatin, 1954 Thermodynamic fluctuations in protein molecules, 2740 Protein activator Protein hormone Solid phase synthesis of protein activator for lecithin-cholesterol Human pituitary growth hormone: Restoration of full biological activity acyltransferase corresponding to human plasma apoC-I, 1422 by noncovalent interaction of two fragments of hormone, 1476 Protein, ADP,ATP translocator mRNA-dependent synthesis of authentic precursor to human placental Antibody evidence for different conformational states of ADP,ATP lactogen: Conversion to mature hormone form in ascites cell-free translocator protein isolated from mitochondria, 2280 extracts, 1179 Protein, L-arabinose-binding Protein, host serum Structure of L-arabinose-binding protein from Escherichia coli at 5 A Immunologic and fine structure evidence of avidly bound host serum resolution and preliminary results at 3.5 A, 2186 proteins in surface coat of bloodstream trypanosome, 1222 Protein, araC Protein isomerism L-Arabinose operon: Electron microscopy of gene regulation, 1518 Ribonuclease A: Guanidine-unfolded state contains fast- and Protein band 3 slow-refolding species, 1853 Reconstitution of intramembrane particles in recombinants of Protein kinase erythrocyte protein Band 3 and lipid: Effects of spectrin-actin 3':5'-Cyclic GMP-dependent protein kinase: Purification and association, 3891 characterization, 3918 Protein fIlH Guanosine 3':5'-cyclic monophosphate binding proteins in rat tissues, Amplification convertase of complement is controlled by plasma protein 2559 31H, 3268 Proteini kinase activity associated with hemin-controlled repressor of Protein, cap binding rabbit reticulocyte, 3078 Protein binding methylated 5'-terminal sequence, m7GpppN, of Protein synthesis in reticulocyte lysates: Effects of 3':5'-cyclic AMP, eukaryotic messenger RNA, 1559 ATP, and GTP on inhibitions induced by heme-deficiency, Protein, y-carboxyglutamic acid-containing double-stranded RNA, and a reticulocyte translational inhibitor, 1112 -y-Carboxyglutamic acid-containing protein from bone, 1447 Protein kinase (EC 2.7.1.37) Protein carboxymethylase Activation and nuclear translocation of protein kinase during see Protein O-methyltransferase transsynaptic induction of tyrosine 3-monooxygenase, 1058 Protein CHI Activation of 3':5'-cyclic AMP-dependent protein kinase and induction Immunoglobulin variant: y3 heavy chain disease protein CHI, 1552 of ornithine decarboxylase as early events in induction of Protein chimera mixed-function oxygenases, 1241 Functional repressor parts of tetrameric lac repressor-3-galactosidase Radioimmunoassay of bovine heart protein kinase, 54 chimera are organized as dimers, 3529 Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic Protein, chromatin AMP-dependent protein kinase, 1038 Temporal relationships of chromatin protein synthesis, DNA synthesis, Transsynaptically elicited increase of 3':5'-cyclic AMP regulated by and assembly of deoxyribonucleoprotein, 2270 endogenous phosphodiesterase activator, 352 Protein, chromosomal Protein kinase,adenosine 3':5'-cyclic monophosphate-independent Chromosomal proteins: Locations in polytene chromosomes, 2038 Regulation of protein synthesis in rabbit reticulocyte lysates: Determination of in situ distribution of chromosomal proteins, 423 Purification and initial characterization of cyclic 3':5'-AMP Protein cleavage independent protein kinase of heme-regulated translational inhibitor, Protein cleavage during virus assembly: Specificity of assembly 4349 dependent cleavage in bacteriophage T4, 4205 Protein L12 Protein cleavage in vitro DNA dependent synthesis of protein L12 from Escherichia coli mRNA-dependent synthesis of authentic precursor to human placental ribosomes, in vitro, 3156 lactogen: Conversion to mature hormone form in ascites cell-free Protein, large externaltransformation-sensitive extracts, 1179 Changes in cellular glycoproteins after transformation: Identification of Protein, coat specific glycoproteins and antigens in sodium dodecyl sulfate gels, 4457 Antiviral effect on MS-2 coliphage obtained with synthetic antigen, 4636 Protein localization Translation of turnip yellow mosaic virus RNA in vitro: A closed and an (-Galactosidase converted to membrane-bound state by gene fusion, open coat protein cistron, 4437 3423 Protein conformation Protein-losinggastropathy Antibody evidence for different conformational states of ADP,ATP Prevention and suppression by azathioprine of venom-induced translocator protein isolated from mitochondria, 2280 protein-losing gastropathy in dogs, 968 Dynamic properties of isolated acetylcholine receptor proteins: Release Protein, M13 coat of calcium ions caused by acetylcholine binding, 3364 Asymmetric orientation of phage M13 coat protein in Escherichia coli Handedness of crossover connections in d sheets, 2619 cytoplasmic membranes and in synthetic lipid vesicles, 1159 Downloaded by guest on October 5, 2021 4766 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Protein metabolism Nuclear magnetic resonance studies of slowly exchanging peptide Reserve protein metabolism in cotyledons of mung bean seedlings, 3168 protons in cytochrome c in aqueous solution, 1398 Protein-metalconjugate Prediction of three-dimensional structures of enzyme-substrate and Covalent attachment of metal chelates to proteins: Stability in vivo and enzyme-inhibitor complexes of lysozyme, 4261 in vitro of conjugate of albumin with chelate of 'llindium, 3803 Structure of L-arabinose-binding protein from Escherichia coli at 5 A Protein, methyl-acceptor resolution and preliminary results at 3.5 A, 2186 Subcellular distribution of protein carboxymethylase and its endogenous Three-dimensional structure of erabutoxin b neurotoxic protein: substrates in adrenal medulla: Role in excitation-secretion coupling, Inhibitor of acetylcholine receptor, 2991 4050 X-ray absorption edges in iron compounds and proteins, 1384 Protein O-methyltransferase(EC 2.1.1.24) Protein subunit Subcellular distribution of protein carboxymethylase and its endogenous Allelic heterogeneity within allozymes separated by electrophoresis in substrates in adrenal medulla: Role in excitation-secretion coupling, Drosophila pseudoobscura, 4150 4050 Subunit interfaces: Role in allosteric mechanism of hemoglobin, 3793 Protein modification Protein synthesis Simian-virus-40-specific T-antigen: Two forms in abortive and lytic see also Peptide synthesis; Polypeptide synthesis infection, 1097 Competition between cellular and viral mRNAs in vitro is regulated by Protein, nonhistone messenger discriminatory initiation factor, 3040 Acceptor proteins in rat androgenic tissue chromatin, 1954 Control of cell division in Saccharomyces cerevisiae by methionyl-tRNA, Chromosomal proteins: Locations in polytene chromosomes, 2038 1664 Dephosphorylation of nonhistone proteins specifically alters pattern of Coordinate regulation of synthesis of eukaryotic ribosomal proteins, 1547 gene transcription in reconstituted chromatin, 1174 Deficiency in plasma protein synthesis caused by x-ray-induced lethal DNA unwinding component of nonhistone chromatin proteins, 4364 albino alleles in mouse, 3376 Nonhistone chromatin proteins identified in chromatin subunits, 3458 Intracellular site of synthesis and localization of leghemoglobin in root Synthesis of nuclear proteins during DNA repair synthesis in human nodules, 3843 diploid fibroblasts damaged with ultraviolet radiation or Maturation (meiosis) in small Xenopus laevis oocytes induced by N-acetoxy-2-acetylaminofluorene, 1466 injection of maturation promoting factor, 2028 Protein, nonstructural Polypeptide chain initiation in eukaryotes: Initiation factor requirements Sequential translation of nonstructural proteins in cells infected with for translation of natural messengers, 44 Semliki Forest virus mutant, 1936 Position of aminoacylation of individual Escherichia coli and yeast Protein, p30 tRNAs, 405 Synthesis of murine leukemia virus proteins associated with virions Protein kinase activity associated with hemin-controlled repressor of assembled in actinomycin D-treated cells: Persistence of viral rabbit reticulocyte, 3078 messenger RNA, 1154 Purification and characterization of two initiation factors required for Protein phosphorylation maximal activity of highly fractionated globin mRNA translation Dephosphorylation of nonhistone proteins specifically alters pattern of system, 2584 gene transcription in reconstituted chromatin, 1174 Reversion from transformed to normal phenotype by inhibition of Hepatic phenylalanine 4-monooxygenase is a phosphoprotein, 1591 protein synthesis in rat kidney cells infected with Interferon, double-stranded RNA, and protein phosphorylation, 3107 temperature-sensitive mutant of Rous sarcoma virus, 3603 Regulation of dopamine stimulation of striatal adenylate cyclase by an Ribosome-dependent GTPase from yeast distinct from elongation factor endogenous Ca++-binding protein, 3887 2, 73 Steroid hormones regulate phosphorylation of specific protein common Synthesis of murine leukemia virus proteins associated with virions to several target organs, 568 assembled in actinomycin D-treated cells: Persistence of viral Protein, phosphorylcholine-binding messenger RNA, .1154 Size differences among immunoglobulin heavy chains from Synthesis of nuclear proteins during DNA repair synthesis in human phosphorylcholine-binding proteins, 2109 diploid fibroblasts damaged with ultraviolet radiation or Protein polymorphism N-acetoxy-2-acetylaminofluorene, 1466 Genetically determined protein polymorphism in rabbit nervous system, Synthesis of R plasmid protein associated with tetracycline resistance is 3641 negatively regulated, 1509 Infinite allele model with varying mutation rate, 4164 Temperature dependence of cycloheximide-sensitive phase of circadian Protein, precursor cycle in Acetabularia mediterranea, 3216 Cell-free synthesis of rat preproinsulins: Characterization and partial Zein svnthesis in maize endosperm by polyribosomes attached to protein amino acid sequence, 1964 tbodlies,:15 Protein, recA Protein synthesis, cell-free recA protein of Escherichia coli K-12: Identification and radiochemical Cell-free synthesis of rat preproinsulins: Characterization and partial purification, 3979 amino acid sequence, 1964 Proteinrecombination Induction of vitellogenin synthesis by estrogen in avian liver: Human pituitary growth hormone: Restoration of full biological activity Relationship between level of vitellogenin mRNA and vitellogenin by noncovalent interaction of two fragments of hormone, 1476 synthesis, 1442 Human somatotropin: Biological characterization of recombinant Inlitiation factor IF-E3 from rabbit reticulocytes: Purification and molecule, 3463 characterization, 3005 Subunit interactions in mouse myeloma proteins with anti-galactan Initiation of translation directed by 42S and 26S RNAs from Semliki activity, 932 Forest virus in vitro, 3059 Protein refolding Interferon-induced inhibition of nr,te^ synthesis in L-cell extracts: ATP bindingto protease-resistantcore of actin, 2742 ATP-dependent step in w'! -i: .'- .; inhibitor by double-stranded Protein, ribosomal RNA, 3136 Ribosomal proteins of Escherichia coli that stimulate Large subunit ribulosebisphosphate carboxylase messenger RNA from stringent-factor-mediated pyrophosphoryl transfer in vitro, 1839 Euglena chloroplasts, 722 Protein, ribosomal,S1 Mechanism of delayed inhibition of protein synthesis in heme-deficient Lack of ribosomal protein S1 in Bacillus stearothermophilus, 767 rabbit reticulocyte lysates, 3506 Polynucleotide secondary structure altered by ribosomal protein S1, 1824 Mitochondrial protein synthesis regulated by cytoplasmic proteins, 3947 Protein, ribosomal,S6 Monomer molecular weight of T antigen from simian virus 40-infected Regulation of transcription factor p and a subunit of RNA polymerase in and transformed cells, 2254 Escherichia coli B/r, 2285 Poliovirus-induced inhibition of polypeptide initiation in vitro on native Protein, secretory polyribosomes, 1834 Hydrophobicity of NH2-terminal extra piece of immunoglobulin Polypeptide chain initiation in eukaryotes: Mechanism of formation of light-chain precursors: Physiological functions of extra piece, 3273 initiation complex, 298 Protein self-assembly Protein synthesis and actin heterogeneity in calf muscle cells in culture, Brain tubulin polymerization in absence of microtubule associated 2018 proteins, 4397 Protein synthesis in rabbit reticulocyte lysates: Inhibition of protein Protein sequence synthesis by translational inhibitor from heme-deficient lysates and -y-Carboxyglutamic acid-containing protein from bovine bone: Primary relationship to initiation factor that binds Met-tRNAf, 2720 structure, 3374 Protein synthesis in reticulocyte lysates: Effects of 3':5'-cyclic AMP, Hemoglobin Wayne: Frameshift mutation detected in human ATP, and GTP on inhibitions induced by heme-deficiency, hemoglobin alpha chains, 882 double-stranded RNA, and a reticulocyte translational inhibitor, 1112 Membrane penicillinase of Bacillus licheniformis 749/C: Sequence and Protein synthesis in reticulocyte lysates: Phosphorylation of possible repeated tetrapeptide structure of phospholipopeptide region, methionyl-tRNAr binding factor by protein kinase activity of 1457 translational inhibitor isolated from heme-deficient lysates, 3112 Protein solubility Regulation of protein synthesis in rabbit reticulocyte lysates: Supersaturation in sickle cell hemoglobin solutions, 3035 Purification and initial characterization of cyclic 3':5'-AMP Protein, steroid-binding independent protein kinase of heme-regulated translational inhibitor, Photoaffinity site-specific covalent labeling of human 4349 corticosteroid-binding globulin, 4462 Specific in situ cleavage of 16S ribosomal RNA of Escherichia coli Protein structure interferes with function of initiation factor IF-1, 702 see also Beta sheet; Protein folding Translation of turnip yellow mosaic virus RNA in vitro: A closed and an Amin. .... 'elolen.ce f en:.irnerenal rnetallothionein-lB, 3413 open coat protein cistron, 4437 -. Crystc..ii-:, hill' i-l!' .-, :i'.i,-:i-l' tm. m. S', 1844 Protein synthesis, de novo Hen e . .:m ',,,: !:..?. I:ii t':.il ,-:;boxyl groups seen by high field Synthesis of acetylcholine receptors by cultured chick myotubes and nluclear magnetic resonance, 1979 denervated mouse extensor digitorum longuls muscles, 161 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4767

Protein synthesis, inhibition of Qf3ribonucleic acid replicase Induction of mouse type-C virus by translational inhibitors: Q3 RNA replicasereconstituted from covalentlyborided elongation Transcriptional derepressionriof specific class of endogenous virus, 4541 factorTu-Ts complex,1131 Protein synthesis, initiationof Quantumfield theory Inhibition of initiation of protein synthesis by Interactingquantum fields and chronometricprinciple, 3355 7-methylgutanosine-5'-monophosphate, 19 Quasi-linkage Protein synthesis' mitochondrial Heredityof Gix thymocyteantigen associated with murineleukemia Mitochondrial translation products in yeast: Location of determinants on virus:Segregation data simulatinggenetic linkage,2077 mitochondrial DNA, 1083 Protein turnover Degradative rates of proteins correlated with parameter calculated from Radiationdamage amino acid composition and subunit size, 3093 Catalasemonolayers inactivated by irradiationwith 100 keV electrons, Protein, viral 823 Fucose-deficient glycoprotein precursor to Rauscher leukemia virus Radiationeffects in living cells: Structuralmodel, 3360 gp69/71, 2326 Sequentialtranscription of genes of vesicularstomatitis virus, 1504 Pheasant virus: New class of ribodeoxyvirus, 1333 Synthesis of nuclearproteins during DNA repairsynthesis in human Plasma levels of viral protein as diagnostic signal for presence of tumor: diploid fibroblastsdamaged with ultravioletradiation or Murine mammary tumor model, 4190 N-acetoxy-2-acetylaminofluorene, 1466 Proteolysis, limited Radiationlesstransition Role of proteolytic enzymes in biological regulation (A Review), 3825 Medium-inducedradiationless transitions and effect of solvent on Prothrombin radiationlesstransitions, 2533 -y-Carboxyglutamic acid-containing protein from bone, 1447 Radioimmunoassay Protocoproporphyria Antigensand antibodiescrossreactive with type C virusesof woolly Porphyria variegata and porphyria cutanea tarda in siblings: Chemical monkeyand gibbonape in animal models and in humans,1725 and genetic aspects (Addendum), 1323 Gonadotropinfrom nonpregnartsubjects that has physical, Protomer, A immunological,and biologicalsimilarities to human chorionic Hydrolysis of nicotinamide adenine dinucleotide by choleragen and its A gonadotropin, 2885 protomer: Role in activation of adenylate cyclase, 4424 Humansomatotropin: Biological characterization of recombinant Proton relaxation molecule, 3463 Proton relaxation and charge accumulation during oxygen evolution in Radioimmunoassayfor intact Grossmouse leukemiavirus, 2847 photosynthesis, 1196 Radioimmunoassayof bovine heart protein kinase,54 Protoplast, bacterial VitaminK-dependent synthesis and modificationof precursor Fusion of bacterial protoplasts, 2151 prothrombinin culturedH-35 hepatomacells; 2803 Fusion of protoplasts of Bacillus megaterium, 2147 Radiopharmaceutical Provirus Covalentattachment of metal chelates to proteins.Stability in vivo and Fv-I gene product: Effect on proviral DNA formation and integration in in vitro of conjugateof albuminwith chelate of lllindium, 3803 cells infected with murine leukemia viruses, 2236 Structuralcharacterization of bridged99Tc-Sn-dimethylglyoxime Host restriction of Friend leukemia virus: Synthesis and integration of complex:Chemistry of 99mTc-radiopharmaceuticalsprepared by Sn(II) provirus, 2356 reductionof pertechnetate,4287 Integration of murine leukemia virus after exogenous infection, 4095 Radiotherapy Psychology Solid tumormodels for assessmentof differenttreatment modalities: Bandage-backfall reaction: Occurs in infancy, hypothalamic damage, and Systematicsof responseto radiotherapyand chemotherapy,818 catalepsy, 3311 Ramanspectioscopy Pulmonary emphysema Erythrocytemembranes undergo cooperative, pH-sensitive state Molecular abnormality of human alphal-antitrypsin variant (Pi-ZZ) transitionsin physiologicaltemperature range: Evidence from Raman associated with plasma activity deficiericy, 1324 spectroscopy, 3558 Purine Resonanceenhanced coherent anti-Stokes Raman scattering, 3798 Growth of human diploid fibroblasts in absence of glucose utilization, Rana pipiens 4110 Mullercell functionduring spreading depression in frog retina, 1351 Purine biosynthesis Randomvariable, maximally dependent Purine auxotroph deficient in phosphoribosylpyrophosphate Maximallydependent random variables, 286 amidotransferdse and phosphoribosylpyrophosphate aminotransferase Rat activities with normal activity of ribose-5-phosphate amiuiotransferase, Growthof transplantedtails of infant rats in adolescentallogeneic 2458 recipients,3283 Purine metabolism Rat, Gunnstrain Purine metabolism in adenosine deaminase deficiency, 2867 I)efectivefunction of microsomalUDP-glucuronyltransferase in Gunn Purine nucleoside . rats, 289 Conformation of deazapurine.nucleosides and of common purine Reassociationkinetics nucleosides: Study by circular dichroism, 2384 Intracellularforms of adenovirusDNA: Integratedform of adenovirus Purkinje cell DNA appearsearly in productiveinfection, 1043 Purkinje cell degeneration, neurological mutation in mouse, 208 Receptor Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells, 2520 see.also Antigenreceptor, lymphocyte Puromycin Receptor,acetylcholine Induction and decay of glucagon-induced amino acid transport in Acetylcholinereceptors: Localization during synaptogenesis in retina, primary cultures of adult rat liver cells: Paradoxical effects of 1806 cycloheximide arid puromycin, 4511 Dynamicproperties of isolatedacetylcholine receptor proteins: Release Putrescine of calciumions caused by acetylcholinebiinding, 3364 o-Methylornithine, potent competitive inhibitor of ornithine Experimentalmyasthenia in Balb/c mice immunizedwith rat decarboxylase, blocks proliferation of rat hepatoma cells in culture, acetylcholinereceptor from rat denervatedmuscle, 2872 1626 Humanniyasthenia gravis: Electrophysiological and ultrastructural Protein inhibitor to ornithine decarboxylase induced by end products of evidencecompatible with antibodyattachment to acetylcholinereceptor its reaction, .1858 complex, 4584 Regulation of ornithine decarboxylase activity by guanine nucleotides: In Innervationof heart cells in cultureby endogenoussource of cholinergic vivo test in potassium-depleted Escherichia coli, 3502 neurOns, 4506 Pyrimidine Isolatedacetylcholine receptor protein: Kinetics of bindingof Growth of human diploid fibroblasts in absence of glucose utilization, acetylcholineand Ca ions, 3994 4110 Lateralmotion of fluorescentlylabeled acetylcholinereceptors in Pyrimidine analog membranesof developingmuscle fibers, 4594 Incorporation of 5-fluorocytidine in RNA of 5-fluorouracil-treated Photoaffinitylabeling and quaternarystructure of acetylcholinereceptor eukaryotic cells, 1528 from Torpedo, californica, 2624 Pyroglutamic acid Synapseand acetylcholinereceptor synthesis by neuronsdissociated Partial amino-acid sequence of precursor of immumtlnoglotllimilight chain from retina, 2370 c(intaining NH2-termrhinalpyroglutamic acid, 2604 Synapse formationbetween clonal neuroblastomaX gliomahybrid cells Pyrophosphetase and.striatedmuscle cells, 123 Differential synthesis of blocked and unblocked 5'-termini in reovirus Synthesis of acetylcholinereceptors by culturedchick myotubesand mRNA: Effect of pyrophosphate and pyrophosphatase, 3448 denervatedmouse extensordigitorum longus muscles, 161 Pyrophosphoryltransfer Three-dimensional structure of erabutoxin b neurotoxic protein: Ribosomal proteins of Escherichia coli that stimulate Inhibitor of acetylcholine receptor, 299i stringent-factor-mediated pyrophosphoryl transfer in vitro, 1839 Transient change in Na ion conductivity of excitable membranes, 4492 Pyruvate kinase (EC 2.7.1.40) Receptor, (v-adrenergic Hormonal control of pyruvate kinase activity and of gluiconeogenesis in (v-Adrenergic regulation of secretion of mouse saliva rich in nerve growth isolated hepatocytes, 2762 factor, 4210 Pyruvate,orthophosphate dikinase (EC 2.7.9.1) Receptor,/-adrehergic 3-Phosphohistidine isolated from phosphorylated pyruvate, phosphate (-Adrenergic receptors in rat liver: Effects of adrenalectomy, 1343 dikinase, 4415 Affinity label for 3-adrenergic receptor in turkey erythrocytes, 1921 Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion, 4410 Desensitization of 3-adrenergic receptors by 3-adrenergic agonists in cell-free system: Resensitization by guanosine Downloaded by guest on October 5, 2021 4768 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

5'-(3,-y-imino)triphosphate and other purine nucleotides, 1494 Tolerance and dependence evoked by endogenous opiate peptide, 3165 Receptor binding Receptor potential Binding of [:H]dihydroazapetine to alpha-adrenoreceptor-related Effects of deuterium oxide on mechano-sensory receptor, 4703 proteins from rat vas deferens, 2730 Receptor, progesterone Receptor, catecholamine ATP-PPi exchange activity of progesterone receptor, 3443 Coupling of catecholamine receptor from one cell with adenylate cyclase Receptor, ribose from another cell by cell fusion, 4410 Receptor interactions in signalling system: Competition between ribose Receptor, cell membrane receptor and galactose receptor in chemotaxis response, 762 Binding, internalization, and degradation of low density lipoprotein by Receptor, thyrotropin normal human fibroblasts and by fibroblasts from homozygous familial Cholera toxin interactions with thyrotropin receptors on thyroid plasma hypercholesterolemia, 14 membranes, 1679 Concanavalin-A-induced transmembrane linkage of concanavalin A Relationship of gangliosides to structure and function of thyrotropin surface receptors to intracellular myosin-containing filaments, 4575 receptors: Their absence on plasma membranes of thyroid tumor Nucleus-membrane interaction in capping of surface membrane defective in thyrotropin receptor activity, 4060 receptors, 4580 Thyrotropin-ganglioside interactions and relationship to structure and Receptor, cell surface function of thyrotropin receptors, 842 Cell recognition in plants: Determinants of stigma surface and pollen Receptor, water interactions, 2788 Anesthetic stimulation of insect water receptors, 3315 Cultured tumor cells: Affinity isolation by drugs and hormones Recombination covalently bound to glass and Sepharose beads, 2013 see also Deoxyribonucleic acid, recombinant; Genetic recombination; Degradation of cationized low density lipoprotein and regulation of Protein recombination cholesterol metabolism in homozygous familial hypercholesterolemia Kinetics of branch migration in double-stranded DNA, 2299 fibroblasts, 3178 Recombination promoted by superhelical DNA and recA gene of Detection and characterization of cell surface receptors for insulin by Escherichia coli, 3910 means of 125I-labeled autoantibodies against insulin receptor, 4115 Recombination intermediate Low density lipoprotein receptors localized on plasma membrane of Mechanism of genetic recombination: Electron microscopic observation normal human fibroblasts and their absence in cells from familial of recombination intermediates, 3000 hypercholesterolemia homozygote, 2434 Redox enzymes Receptor, complement Charge pair model of bioenergetics: Energy transfer, 2770 Ontogeny of lymphocyte subpopulations in human fetal liver, 919 Charge pair model of bioenergetics: Redox enzymes, 2392 Receptor, concanavalin A Redox equilibrium Active cell edge and movements of concanavalin A receptors of surface of Thermodynamic model of regulation: Modulation of redox equilibria in epithelial and fibroblastic cells, 4085 camphor monoxygenase, 1078 Lateral transport on cell membranes: Mobility of concanavalin A Redox titration receptors on myoblasts, 2409 Redox titration of fluorescence yield of photosystem II, 2211 Reversion from transformed to normal phenotype by inhibition of Redshift protein synthesis in rat kidney cells infected with Chronometric cosmology, theoretical foundations, 669 temperature-sensitive mutant of Rous sarcoma virus, 3603 Reductive alkylation Receptor, dihydrotestosterone Initiation factor IF-E3 from rabbit reticulocytes: Purification and Androgen insensitivity in man: Genetic heterogeneity, 891 characterization, 3005 Receptor, dopamine Regulation, biochemical Dopamine receptors in human and calf brains, using [3H]apomorphine Synthesis of R plasmid protein associated with tetracycline resistance is and an antipsychotic drug, 4354 negatively regulated, 1509 Receptor, estrogen Thermodynamic model of regulation: Modulation of redox equilibria in Alpha-fetoprotein: Major high-affinity estrogen binder in rat uterine camphor monoxygenase, 1078 cytosols, 1452 Regulation, biological Receptor, galactose Role of proteolytic enzymes in biological regulation (A Review), 3825 Receptor interactions in signalling system: Competition between ribose Relativistic hydrodynamics receptor and galactose receptor in chemotaxis response, 762 Relativistic spherical vortex (correction), 2527 Receptor, hepatic, avian Stringent factor from Escherichia coli directs ribosomal binding and Hepatic receptor of avian origin capable of binding specifically modified release of uncharged tRNA, 687 glycoproteins, 341 Relativistic spherical vortex Receptor, hormone Relativistic spherical vortex (correction), 2527 Coupling of catecholamine receptor from one cell with adenylate cyclase Stringent factor from Escherichia coli directs ribosomal binding and from another cell by cell fusion, 4410 release of uncharged tRNA, 687 Dose-dependent depletion of nuclear receptors by L-triiodothyronine: Renal blood flow Role in induction of growth hormone synthesis in cultured GH1 cells, Solute and water movement in kidney, 252 3877 Renal glomeruli Hormonal control of meiosis: Specificity of 1-methyladenine receptors in Antigen related to mammalian type-C RNA viral p30 proteins is located starfish oocytes, 1669 in renal glomeruli in human systemic lupus erythematosus, 233 Hormone and neurotransmitter receptors in established vascular Renal lymph endothelial cell line, 1612 Apolipoproteins in rat serum and renal lymph, 1757 Sex differences in binding of human growth hormone to isolated rat Renal metabolism hepatocytes, 847 Renal CO2 production from glutamine and lactate as function of arterial Targeted attachment of peptides and proteins to solid supports, 3516 perfusion pressure in dog, 4235 Receptor, insulin Reovirus Binding of insulin to isolated nuclei, 1427 Differential synthesis of blocked and unblocked 5'-termini in reovirus Detection and characterization of cell surface receptors for insulin by mRNA: Effect of pyrophosphate and pyrophosphatase, 3448 means of 125I-labeled autoantibodies against insulin receptor, 4115 Repressor Receptor, mechano-sensory Construction and propagation of defective simian virus 40 genome Effects of deuterium oxide on mechano-sensory receptor, 4703 bearing operator from bacteriophage X, 1068 Receptor, membrane Construction of plasmids carrying the cI gene of bacteriophage X, 4174 Clustering and endocytosis of membrane, receptors can be induced in Repressor, Cro protein mature erythrocytes of neonatal but not adult humans, 4075 DNA-binding protein with characteristics expected for Cro protein of Receptor, 1-methyladenine bacteriophage X, a repressor essential for lytic growth, 2249 Hormonal control of meiosis: Specificity of 1-methyladenine receptors in Repressor, hemin-controlled starfish oocytes, 1669 Protein kinase activity associated with hemin-controlled repressor of Receptor mobility rabbit reticulocyte, 3078 Lateral motion of fluorescently labeled acetylcholine receptors in Repressor, lac membranes of developing muscle fibers, 4594 Chemical and enzymatic synthesis of lactose operator of Escherichia coli Lateral transport on cell membranes: Mobility of concanavalin A and its binding to lactose repressor, 91 receptors on myoblasts, 2409 Functional repressor parts of tetrameric lac repressor-3-galactosidase Receptor, nicotinic acetylcholine chimera are organized as dimers, 3529 Specificity of synapse formation, 3544 Isolation of hybrid lac repressors made in vitro between normal lac Receptor, opiate repressor and its homogeneous tryptic core, 3103 Endogenous opiate analgesic isolated from human blood, 2226 lac repressor: 3-Fluorotyrosine substitution for nuclear magnetic -F-Endorphinis . p',-tcn ,ana!:cs.ci .1-Tent,2895 resonance studies, 3471 MNIorphinle-like ; l)' ifi - ii.i,l; 'liill.,:lill' brain: Isolation, structure Reproductive isolation elucidation, cm..ii '"lI',', 't- :;-.. .1. - .-piate receptor, 2515 Ethological isolation and mating experience in Drosophila paulistorum, Morphine-like peptides in mammalian brain: Isolation, structure 975 elucidation, and interactions with opiate receptor (correction), 4247 Reserpine Opiate receptor: Autoradiographic localization in rat brain, 3729 Activation and nuclear translocation of protein kinase during Opiate receptor: Model explaining structure-activity relationships of transsynaptic induction of tyrosine 3-monooxygenase, 1058 opiate agonists and antagonists, 4215 Resonance enhancement Opioid activity of a peptide, ,B-lipotropin-(61-91), derived from Resonance enhanced coherent anti-Stokes Raman scattering, 3798 (-lipotropin, 1821 Resonance Raman spectroscopy Preliminary analysis of 1H and :1'Cspectral and relaxation behavior in Assignment of locus required for flavoprotein-linked monooxygenase methionine-enkephalin, 2589 expression to human chromosome 2, 4266 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4769

Rapid-flow resonance Raman spectroscopy of photolabile molecules: Retinal Rhodopsin and isorhodopsin, 1 Retinal has highly dipolarvertically excited singlet state: Implications Respiration for vision, 2169 Proliferation of Rous sarcoma virus-infected, but not of normal, chicken Retinal degeneration fibroblasts in oxygen-enriched environment, 1265 Purkinjecell degeneration,neurological mutation in mouse, 208 Restricted convergence Retinal protein Maximal functions: Poisson integrals on symmetric spaces, 2547 Enhancedlabeling of retinal proteinduring regeneration of optic nerve Restriction in goldfish,828 Radiation leukemia virus: Biological and serological characterization, Retina, neural 4675 Synthesis of type II collagenin vitro by embryonicchick neuralretina Restriction endonuclease tissue, 4420 Amplification in Escherichia coli of enzymes involved in genetic Retinoic acid recombination: Construction of hybrid ColEl plasmids carrying Changesin levels of cellularretinol- and retinoic-acid-bindingproteins of structural gene for exonuclease I, 3492 liver and lung duringperinatal development of rat, 3976 Biochemical mapping of eukaryotic viral DNA by linked Retinol transcription-translation cell-free system, 2747 Changesin levels of cellularretinol- and retinoic-acid-bindingproteins of Characterization of 2-gm DNA of Saccharomyces cerevisiae by liver and lung duringperinatal development of rat, 3976 restriction fragment analysis and integration in an Escherichia coli Retinyl acetate plasmid, 2072 VitaminA-containing lipocytes and formationof type III collagenin Circular DNA of yeast episome with two inverted repeats: Structural liver injury, 3719 analysis by restriction enzyme and electron microscopy, 3030 Retinylidenechromophore Constructio,l am(1dpi-opa.I'atioiii if defective simian virus 40 genome Assignmentof locus requiredfor flavoprotein-linkedmonooxygenase bearing opl'irllor I'rmoiln)i('tliriophage X, 1068 expressionto humanchromosome 2, 4266 Human papilloma virus DNA: Physical mapping and genetic Retravirus heterogeneity, 1310 Geneticallytransmitted retravirus isolated from Mus cervicolor,3579 Hybridization of RNA to double-stranded DNA: Formation of R-loops, Reversetranscriptase 2294 see Deoxyribonucleicacid nucleotidyltransferase,ribonucleic acid Integrated simian virus 40 sequences in transformed cell DNA: Analysis dependent using restriction endonucleases, 1102 Review Mapping of in vivo messenger RNAs for bacteriophage 4X174, 3519 Endoplasmicreticulum: A cytochemist'sview (A Review),2781 Mapping of in vivo messenger RNAs for bacteriophage ibX174 Mucopolysaccharidoses(A Review),630 (correction), 4247 Mucopolysaccharidoses(A Review) (correction),2165 Mismatched base-pair regions in polyoma heteroduplex DNA: Fate Role of proteolyticenzymes in biologicalregulation (A Review),3825 during infection of mouse cells,' 3073 Rheumatoid arthritis Preparative fractionation of DNA restriction fragments by reversed Collagenaseand prostaglandinsproduced by isolated adherent phase column chromatography, 3117 rheumatoidsynovial cells, 945 Restriction assay for integrative recombination of bacteriophage X DNA Rheumatoidfactor in vitro: Requirement for closed circular DNA substrate, 3524 Rheumatoidfactor and tumor-hostinteraction, 2106 Somatic rearrangement of immunoglobulin genes coding for variable and Rhodium constant regions, 3628 Modulationof membranefluidity: Homogeneous catalytic hydrogenation Restriction endonuclease BamI of phospholipidsand phospholipid-watermodel biomembranes,3971 Molecular cloning of DNA fragments produced by restriction Rhodophyta endonucleases SalIl and BamI, 1537 Biliproteinsof cyanobacteriaand Rhodophyta:Homologous family of Restriction endonuclease, EcoRI photosyntheticaccessory pigments, 428 Biochemical construction of specific chimeric plasmids from ColEl DNA Rhodopseudomonas and unfractionated Escherichia coli DNA, 3838 Anaerobicgrowth of a Rhodopseudomonasspecies in darkwith carbon Intracellular forms of adenovirus DNA: Integrated form of adenovirus monoxideas sole carbonand energysubstrate, 3298 DNA appears early in productive infection, 1043 Rhodopsin Molecular cloning of DNA from F sex factor of Escherichia coli K-12, 64 see also Isorhodopsin Restriction endonuclease, HpaII Assignmentof locus requiredfor flavoprotein-linkedmonooxygenase Mapping of three species of polyoma mRNA, 1480 expressionto humanchromosome 2, 4266 Restriction endonuclease Hph Rapid-flowresonance Raman spectroscopy of photolabilemolecules: Restriction endonuclease isolated from Haemophilus parahaemolyticus, Rhodopsinand isorhodopsin,1 293 Retinal has highly dipolarvertically excited singlet state: Implications Restriction endonuclease SalIl for vision, 2169 Molecular cloning of DNA fragments produced by restriction Rho factor endonucleases SalI and BamI, 1537 Conditionallethal mutants of Escherichiacoli defective in transcription Restriction enzyme terminationfactor rho, 1959 Plasmid cloning vehicle allowing regulated expression of eukaryotic DNA Inductionof sigma factorsynthesis in Escherichiacoli by the N gene in bacteria, 3900 productof bacteriophagelambda, 4405 Restriction mapping Regulationof transcriptionfactor p and a subunit of RNA polymerasein Origin and direction of synthesis of bacteriophage fl DNA, 2341 Escherichiacoli B/r, 2285 Reticulocyte Ribavirin Initiation factor IF-E3 from rabbit reticulocytes: Purification and Conformationalproperties of ribavirin,4257 characterization, 3005 Riboflavin Protein kinase activity associated with hemin-controlled repressor of Responsesof Phycomycesindicating optical excitationof lowest triplet rabbit reticulocyte, 3078 state of riboflavin,1969 Purification and characterization of two initiation factors required for 1-j-D-Ribofuranosylbenzimidazole,5,6-dichloro- maximal activity of highly fractionated globin mRNA translation MessengerRNA competitionin shutoff of humaninterferon production, system, 2584 1621 Transcription in vitro of chromatin in presence of mercurated RibonucleaseA (EC 3.1.4.22) nucleotide, 1564 RibonucleaseA: Guanidine-unfoldedstate containsfast- and Reticulocyte lysate slow-refoldingspecies, 1853 Mechanism of delayed inhibition of protein synthesis in heme-deficient RibonucleaseH rabbit reticulocyte lysates, 3506 see Hybridnuclease Protein synthesis in reticulocyte lysates: Effects of 3':5'-cyclic AMP, RibonucleaseI (EC 3.1.4.22) ATP, and GTP on inhibitions induced by heme-deficiency, RNase sensitivity of anteriormorphogenetic determinant in insect egg double-stranded RNA, and a reticulocyte translational inhibitor, 1112 (Smittia sp., Chironomidae,Diptera), 3739 Protein synthesis in reticulocyte lysates: Phosphorylation of Tumorcell proliferationinhibited by dimerizedribonuclease, 573 methionyl-tRNAf binding factor by protein kinase activity of Ribonuclease P translational inhibitor isolated from heme-deficient lysates, 3112 RibonucleaseP substratespecificity: Cleavage of bacteriophage Regulation of protein synthesis in rabbit reticulocyte lysates: 4080-inducedRNA, 1912 Purification and initial characterization of cyclic 3':5'-AMP RibonucleaseS' independent protein kinase of heme-regulated translational inhibitor, Crystallinesemisynthetic ribonuclease-S', 1844 4349 Ribonuclease,serum Retina Elevated serum ribonuclease in patients with pancreatic cancer, 2308 Acetylcholine receptors: Localization during synaptogenesis in retina, Ribonucleicacid, analogincorporation 1806 Incorporation of 5-fluorocytidine in RNA of 5-fluorouracil-treated Distributionof 3':5'-cyclicAMP and 3':5'-cyclicGMP in rabbitretina in eukaryotic cells, 1528 vivo: Effects of dark and light adaptation and ischemia, 4442 Ribonucleicacid, bacteriophageT7 Gradient of adhesive specificity in developing avian retina, 410 Polycistronic and overlapping bacteriophage T7 late transcripts detected Muller cell function during spreading depression in frog retina, 1351 by in vitro translation, 312 Synapse and acetylcholine receptor synthesis by neurons dissociated Ribonucleicacid, double-stranded from retina, 2370 Chromosomal gene required for killer plasmid expression, mating, and Retina, embryonic spore maturation in .Sc.,r:".r-^.re cerevisiae, 2061 Retina-specific cell-aggregating factor isolated from membranes of Dependence of ill.'lt r.-mmlilm[;. I: 'iil .n nucleic acid conformation, 3788 embryonic neural retina tissue, 3594 Double-stranded RNA in chromatin transcripts formed by exogenous RNA polymerase, 1121 Downloaded by guest on October 5, 2021 4770 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Inheritance (f killer phenotypes and doulle-stranded RNA in U stilago Ribonucleic acid, messenger, synthesis mayvdis, 594 Initiation of in iitro mRNA synthesis from the wild-type lac promoter Intfernfer1, douhmlle-stranded RNA, and protein phosphorylation, 3107 (correction), 1373 lProtein synthesis in reticuilocyte lysates: Effects of 3':5'-cyclic AMII, Transcription in uitro of chromatin in presence of mercurated A'T'. and (GTIP on inhibitions induced lby hemne:-deficiency, nucleotide, 1564 doiiile-stranded INA, and a reticulocyte translational inhibitor, 1112 Transcription-translation and translation-messenger RNA decay Ribonucleic acid, helical coupling: Separate mechanisms for differenit mnessengers, 1126 Ivdrolvtic stability of helical RNA: Selective advantage for natural Ribonucleic acid, messenger, 5-terminal structure :1,5'-i)ond. 1149 5' End of lpoliovirus mRNA is inot capped with m'G(5')ppp(5')Np, 375 Ribonucleic acid, heterogeneous nuclear Protein binding methylated 5'-terminal sequence, m7GpppN, of lPrimary transcripts in Ehrlich 1ascites cells measured by tetral)hosphate eukarvotic messenger RNA, 1559 determinafion, 1994 5' -Terminal structutre of poliovirus polyribosomal RNA is piUp, 327 Ribonucleic acid, high-molecular-weight Ribonucleic acid, messenger, translation Simultianeomisdletection of reverse transcriptase and high molecular uPolypeptide chain initiation in eukaryotes: Initiation factor requirements weighlt RNA in tissue of patients with Hodgkin's disease and in human for translation uofniatural messengers, 44 patients with leukemia, 4(649 Ribonucleic acid, messenger, Ribonucleic acid, mammalian Nucleotide sequence of region preceding trp mRNA initiation site aind ILymphocyte stimulation: Rapid multiparameter analysis, 2881 role in promoter anid operator function, 2351 Thyroid horrmniIe stimulates de no,o growth hormone synthesis in Ribonucleic acid, messenger, viral cultured GHi( cells: Accumulation of rate limiting RNA species in Adenovirus messenger RNA mapped by electron microscopy, 2069 induction, 3369 (Competition between cellular and viral mRNAs in vitro is regulated by Ribonucleic acid, messenger messenger discriminatory initiation factor, :3040 Messenger specifying sequences in DNA of chromatin subunits, 1572 D)ifferential synthesis of blocked and unblocked 5'-termini in reovirus Niri':r:m'-. ;- ,',iirm o f synthetic antibiotics, with a new mode of action: mRNA: Effect of pyrophosphate and pyrophosphatase, 3448 ,' I)i., ' i'ii' ...i.:I specific messenger RNA classes, 3386 I)NA copies of poliovirus RNA synthesized in high yields and at high Ribonucleic acid, messenger, actin specific activities, 2191 ('hick cytoplasmic actin and muscle actin have different structural genes, Mapping of in viuo messenger RNAs for bacteriophage OXX174, 3519 2:346 Mapping of in vivo messenger RNAs for bacteriophage ?X174 Ribonucleic acid, messenger, albumin (correction), 4247 (mClonalvariation in albumnin messenger RNA activity in hepatoma cells, Mapping of three species of polyoma mRNA, 1480 20(56( Rauscher nmurine leukemia virus-specific polypeptides synthesized in Ribonucleic acid, messenger, chloroplast t'itro, 356 Large subunit ribulosehisphosphate carboxylase messenger RNA from Sequential transcription of genes of vesicular stomatitis virus, 1504 ;ugh 'na chloroplasts, 722 Synvthesis of murine leukemia virus proteins associated with virions Ribonucleic acid, messenger, &-crystallin assembled in actinomycin D)-treated cells: Persistence of viral Quantitation of i-crystallin messenger RNA during lens induction in messenger RNA, 1154 chick em1bryos, 2808 Ribonucleic acid, messenger, vitellogenin Ribonucleic acid, messenger, ferritin Induction of vitellogenin synthesis by estrogen in aviani liver: Translational control in regiulation of ferritin synthesis by iron, 857 Relationship between level of vitellogenin mRNA anid vitellogenin Ribonucleic acid, messenger, globin synthesis, 1442 Erythroid cell differentiation: Murine erythroleukemia cell variant with Ribonucleic acid, mouse unili(itue pattern of induction by polar complounds, 12:32 Nucleotide sequences in mouse IDNA and RNA specific for Moloney Purification and characterization of two initiation factors required for sarcoma virus, 3705 maximal activity of highly fractionated globin mRNA translation Ribonucleic acid nucleotidyltransferase system, 2584 l,-Arabinose operon: Electron microscopy of gene regulation, 1518 Stepwise biosynthesis in vitro of glohbin genes from globin mRNA by Molecular structure of yeast RNA polymerase III: Tripartite IDNA polymerase of avian myeloblastosis virus, 3418 transcriptive system in lower eukaryotes, 1024 Transcriptio n 0 itro of chromatin in presence of mercurated 'Transcription in yeast: (i-Amanitin sensitivity andI other properties nucleot ide, 1564 which distinguish between RNA polymerases I and III, 1029 Unequal accumulation of(va- and 3-globin mRNA in erythropoietic mouse Ribonucleic acid nucleotidyltransferase (EC 2.7.7.6) slpleen, 1811 Conversion of Bacillus subtilis RNA polymerase activity in uitro by a Ribonucleic acid, messenger, immunoglobulin kappa chain protein induticedby phage SPOI (correction), 661 Sequences related to immunoglhobulin kappa chain messenger RNA in T IDNA fragment from origin of single-strand to double-strand D)NA cells, 2467 replication of bacteriophage fd, 49 Somatic rearrangement of immunoglobulin genes coding for variable and D)oufble-stranded RNA in chromatin transcripts formed by exogenous constant regions, 3628 RNA polymerase, 1121 Ribonucleic acid, messenger, immunoglobulin light chain Inductioni of sigma factor synithesis in Escherichia coli by the N gene Hydrophobicity of NH,)-terminal extra piece of immunoglobulin product of bacteriophage lambda, 4405 light-chain precursors: Physiological functions of extra piece, 3273 IPutative sigma factor from Chlamydomonas reinhardi: Purification and No detectiable reiteration of genes coding for mouse MOPC 41 characterization, 3961 immunioglobulin light-chain mRNA, 727 Regulation of transcriptioni factor p anami subunit of RNA polymerase in coli lPartial aminmo-acid sequence of precursor of immutnoglobulin light chain Es-cherichia B/r, 2285 crtalining NH-)-termninal pyrogtlutamic acid, 2604 Specific binding of formylated initiator-tRNA to Escherichia colt RNA Reiteratimon frequenicy of immunoglohbulin light chain genes: Somatic polymerase, 3064 RNA generation of antibiody diversity, 203 Stereochemistry of polymerization by I)NA-dependent polymerase Ribonucleic acid, messenger, interferon from Escherichia coli: Use of diastereomeric ATP-analogue, 2987 nitro of chainll in Messenger RNA competition in shutoff of human interferon production, Transcription in immunoglobulin kappa light genes 1621 isolated mouse myeloma nuclei and chromatin, 775 Ribonucleic acid, messenger, mammalian Ribonucleic acid nucleotidyltransferase I D)ifferential degradation of messenger RNAs in mammalian cells, 2634 Amino acids and control of inucleolar size, the activity of RNA 3201 large product of cell-free translation of messenger RNA coding for polymerase I, and D)NA synthesis in liver, corticotropin, 4319 Ribonucleic acid nucleotidyltransferase, ribonucleic acid dependent Mammalian messenger RNA lacking polyadenylate segment, 3088 Q(3 RNA replicase reconstituted from covalently bonded elongation mRNA sequences in nuclear 30S ribonucleoprotein suibcomplexes, 2725 factor 'II'Ts complex, 1131 Ptartial lpurification andI characterization of mRNA for rat preproinsutlin, Ribonucleic acid oncogenic virus 3539 Bovine leukemia virus: Exogenous RNA oncogenic virus, 1014 Synthesis of with of light chains directed Ribonucleic acid-protein interaction polypeptides properties myosin 1824 by RNA extracted from muscle cultures, 4599 Polynucleotide seconidary structure altered by ribosomal protein SI, Ribonucleic acid, messenger, map Ribonuclease P) substrate specificity: Cleavage of bacteriophage Mapping of three species of polyoma mRNA, 1480 ,80-induced RNA, 1912 Ribonucleic acid, messenger, methylated Ribonucleic acid, ribosomal of in mouise Dlifferential synthesis of blocked and unblocked 5'-termini in reovirus Biphasic stimulation polyamine biosynthesis primary kidniey mRNA: Effect of pyrophosphate and pyrophosphatase, 3448 cells by infection with polyoma virus: Uncoupling from D)NA aind Short-lived methylated messenger RNA in mouse kidney, 2609 rRNA synthesis, 4022 Ribonucleic acid, messenger, nonpolyadenylylated Expression of human and suppression of mouse nucleolus organizer lranslation of nonpolyadenylylated messenger RNA of sea urchin activity in mouse--human somatic cell hybrids, 4531 embryos, 148 Specific in situ cleavage of 16S rilbosomal RNA of Escherichia noli Ribonucleic acid, messenger, penicillinase interferes with function of initiatiun factor IF-1, 702 Memnbrane t)enicillinase of Bacillus lichoniformis 749/C: Sequence and Ribonucleic acid, 5S possible repeated tetrapeptide structure of pihospholipopeptide region, Role of 5S RNA in assembly and function of 50S subunit from 1457 EIslchtrichia colt, 2221 Ribonucleic acid, messenger, ribosomal protein Ribonucleic acid, secondary structure ('uCuordinate regulation of synthesis of eukaryotic rihosomal proteins, 1547 Secondary structure of single-stranded RNA from iacteriophage MS2 fly Ribonucleic acid, messenger, somatotropin electron microscoipy, 307 lPr-growth hormone: Product of translation in Ivitro of messenger RNA Ribonucleic acid, single-stranded coding fimrgrowth hormone, 29 Secuoniary structure of single-stranded RNA from bacteriophage MS2 fiy electron microscopy, 307 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4771

Viroids are single-stranded covalently closed circular RNA molecules activities with normal activity of ribose-5-phosphate aminotransferase, existing as highly base-paired rod-like structures, 3852 2458 Ribonucleicacid structure Ribosomal subunit, 50S see also Polynucleotide secondary structure Low resolution model for 50S subunit of Escherichia coli ribosomes, Platinum binds selectively to phosphorothioate groups in mono- and 2379 polynucleotides: General method for heavy metal staining of specific Role of 5S RNA in assembly and function of 50S subunit from nucleotides, 2536 Escherichia coli, 2221 Ribonucleic acid synthesis Ribosome Activation of chromatin by acetylation of histone side chains, 3937 see also Polyribosome; Protein, ribosomal Induction of delayed early RNA of bacteriophage T4 in vitro, 2569 Ribosome acceptor site Ribonucleic acid, transfer, aminoacylation Stringent factor from Escherichia coli directs ribosomal binding and Kinetic proofreading in amino acylation of tRNAII, 1164 release of uncharged tRNA, 707 Position of aminoacylation of individual Escherichia coli and yeast Ribosomepeptidyl site tRNAs, 405 Stringent factor from Escherichia coli directs ribosomal binding and Ribonucleicacid, transfer,chloroplast release of uncharged tRNA, 707 Euglena chloroplast tRNAs: Transcriptional origin, 1984 Ribulosebisphosphatecarboxylase (EC 4.1.1.39) Ribonucleicacid, transfer,conformation Large subunit ribulosebisphosphate carboxylase messenger RNA from Denatured tRNA21u" from Escherichia coli, 2216 Euglena chloroplasts, 722 Ribonucleicacid, transfer,formylmethionyl- Rickets Protein synthesis in rabbit reticulocyte lysates: Inhibition of protein Hypophosphatemia: Mouse model for human familial hypophosphatemic synthesis by translational inhibitor from heme-deficient lysates and (vitamin D-resistant) rickets, 4667 relationship to initiation factor that binds Met-tRNAf, 2720 Riemannianmanifolds Regulation of protein synthesis in rabbit reticulocyte lysates: Conjugate points on a limiting extremal, 1800 Purification and initial characterization of cyclic 3':5'-AMP Rifampicin independent protein kinase of heme-regulated translational inhibitor, Putative sigma factor from Chlamydomonas reinhardi: Purification and 4349 characterization, 3961 Specific binding of formylated initiator-tRNA to Escherichia coli RNA Riverbed polymerase, 3064 Bedload measurements, East Fork River, Wyoming, 1000 Ribonucleic acid, transfer, glutamic acid Rohon-Beardcell Denatured tRNA2c-lu from Escherichia coli, 2216 Development of action potential mechanism of amphibian neurons Ribonucleicacid, transfer,isoleucine isolated in culture, 1641 Kinetic proofreading in amino acylation of tRNAIIe, 1164 Root nodule Ribonucleicacid, transfer,methionine Intracellular site of synthesis and localization of leghemoglobin in root Control of cell division in Saccharomyces cerevisiae by methionyl-tRNA, nodules, 3843 1664 Rotifer Ribonucleicacid, transfer,nonacylated see Asplanchna sieboldi Stringent factor from Escherichia coli directs ribosomal binding and Rubber release of uncharged tRNA, 0707 Soft polymers: Time-dependent response in moderately large Ribonucleicacid, transfer,synthesis deformations, 981 Growth delay induced in Escherichia coli by near ultraviolet radiation, Rubredoxin 59 Applications of synchrotron radiation to protein crystallography, 128 Ribonucleic acid, transfer, yeast Ruthenium Genetic analysis of transposable suppressor gene in Saccharomyces Metal cluster in catalysis: Hydrocarbon reactions, 4274 cerevisiae, 4623 Transfer of tRNAs to somatic cells mediated by Sendai-virus-induced fusion, 2793 Saccharomycescerevisiae Ribonucleicacid tumorvirus Activity of yeast extracts in cell-free stimulation of DNA replication, see also Tumor virus; specific viruses 3933 Genetically transmitted retravirus isolated from Mus cervicolor, 3579 Acyl coenzyme A synthetase activity is required for repression of yeast Independent regulation of endogenous and exogenous avian RNA tumor acetyl coenzyme A carboxylase by exogenous fatty acids, 386 virus genes, 2259 Biogenesis of mitochondria: Molecular mapping of mitochondrial genome Nucleotide sequences in mouse DNA and RNA specific for Moloney of yeast, 2082 sarcoma virus, 3705 Characterization of 2-pm DNA of Saccharomyces cerevisiae by Primate type-C virus nucleic acid sequences (woolly monkey and baboon restriction fragment analysis and integration in an Escherichia coli types) in tissues from patient with acute myelogenous leukemia and in plasmid, 2072 viruses isolated from cultured cells of same patient, 2113 Chromosomal gene required for killer plasmid expression, mating, and Primate type-C virus nucleic acid sequences (wooly monkey and baboon spore maturation in Saccharomyces cerevisiae, 2061 types) in tissues from patient with acute myelogenous leukemia and in Circular DNA of yeast episome with two inverted repeats: Structural viruses isolated from cultured cells of same patient (correction), 3320 analysis by restriction enzyme and electron microscopy, 3030 RNA-dependent DNA polymerase, different from known viral reverse Control of cell division in Saccharomyces cerevisiae by methionyl-tRNA, transcriptases, in chicken system, 3025 1664 Synthesis of murine leukemia virus proteins associated with virions Coordinate regulation of synthesis of eukaryotic ribosomal proteins, 1547 assembled in actinomycin D-treated cells: Persistence of viral Functional genetic expression of eukaryotic DNA in Escherichia coli, messenger RNA, 1154 1471 Ribonucleic acid, viral Genetic analysis of transposable suppressor gene in Saccharomyces Anticomplementary nature of smaller DNA produced during synthesis of cerevisiae, 4623 extensive DNA copies of poliovirus RNA, 3408 Modified recombination and transmission of mitochondrial genetic 4608 Bacteriophage T3 and T7 early RNAs are translated by eukaryotic 80S markers in rho minus mutants of Saccharomyces cerevisiae, ribosomes: Active phage T3 coded S-adenosylmethionine cleaving Recombination in Saccharomyces cerevisiae: DNA repair mutation enzyme is synthesized, 2752 associated with elevated mitotic gene conversion, 2828 Circularization of avian oncornavirus RNA genome during proviral DNA Saccharomyces cerevisiae mutant defective for nuclear fusion, 3651 synthesis studied by reverse transcription in vitro, 1329 Yeast histones: Synthesis in cell cycle, 1863 Influenza virus genome consists of eight distinct RNA species, 3045 Saliva Interferon-induced inhibition of protein synthesis in L-cell extracts: (Y-Adrenergicregulation of secretion of mouse saliva rich in nerve growth ATP-dependent step in activation of inhibitor by double-stranded factor, 4210 RNA, 3136 Salmonella/microsome test Location of envelope-specific and sarcoma-specific oligonucleotides on Carcinogens as mutagens in Salmonella/microsome test: Assay of 300 RNA of Schmidt-Ruppin Rous sarcoma virus, 447 chemicals, 950 Mapping of influenza virus genome: Identification of hemagglutinin and Salmonella typhimurium neuraminidase genes, 2142 Morphogenesis of bacterial division septum: Class of septation-defective Mapping oligonucleotides of Rous sarcoma virus RNA that segregate mutants, 1882 with polymerase and group-specific antigen markers in recombinants, Protein-protein interaction in transport: Periplasmic histidine-binding 3952 protein J interacts with P protein, 1877 Structure of amino-acid accepting 3'-end of high-molecular-weight Receptor interactions in signalling system: Competition between ribose eggplant mosaic virus RNA, 737 receptor and galactose receptor in chemotaxis response, 762 Translation of turnip yellow mosaic virus RNA in vitro: A closed and an Sarcoidosis open coat protein cistron, 4437 Elevated angiotensin converting enzyme in lymph nodes containing Ribonucleoproteinparticle non-necrotizing granulomas in sarcoidosis, 2137 RNase sensitivity of anterior morphogenetic determinant in insect egg Sarcomavirus, Moloney (Smittia sp., Chironomidae, Diptera), 3739 Nucleotide sequences in mouse DNA and RNA specific for Moloney Ribonucleoproteinsubcomplexes sarcoma virus, 3705 mRNA sequences in nuclear 30S ribonucleoprotein subcomplexes, 2725 Sarcomavirus, Rous Ribonucleoside-diphosphatereductase (EC 1.17.4.1) Calcium-dependent regulatory protein of cyclic nucleotide metabolism in Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate normal and transformed chicken embryo fibroblasts, 2711 reductase dependent upon glutathione, 2275 Mapping oligonucleotides of Rous sarcoma virus RNA that segregate Ribose-5-phosphateaminotransferase with polymerase and group-specific antigen markers in recombinants, Purine auxotroph deficient in phosphoribosylpyrophosphate 3952 amidotransferase and phosphoribosylpyrophosphate aminotransferase Microfilament organization and surface topography: Changes upon Downloaded by guest on October 5, 2021 4772 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

transformation of chick embryo fibroblasts with Rous sarcoma virus, Serotonin 4065 Antagonismof 5-hydroxykynurenamineagainst serotonin action on Proliferation of Rous sarcoma virus-infected, but not of normal, chicken platelet aggregation,643 fibroblasts in oxygen-enriched environment, 1265 Serum Reversion from transformed to normal phenotype by inhibition of Inhibitionof arachidonicacid releasefrom cells as biochemicalaction of protein synthesis in rat kidney cells infected with anti-inflammatorycorticosteroids, 1730 temperature-sensitive mutant of Rous sarcoma virus, 3603 Severe combinedimmunodeficiency Rous-sarcoma-virus-transformed fibroblasts having low levels of Normallevel of adenosinedeaminase activity in red cell lysates of plasminogen activator, 3613 carriersand patients with severe combinedimmunodeficiency disease, Temperature-sensitive changes in surface modulating assemblies of 104 fibroblasts transformed by mutants of Rous sarcoma virus, 2047 Residualenzyme activity in fibroblastsfrom patients with adenosine Saxitoxin deaminasedeficiency and combinedimmunodeficiency: Evidence for Pharmacologic characterization of Na+ ionophores in L6 myotubes, 1355 mutant enzyme,213 Scanningelectron microscopy Sex ratio Biological molecules identified in situ at high resolution via fluorescence Sex ratio,sex change,and naturalselection, 3656 excited by scanning electron beam, 317 Sherpas Fossil microorganisms from 2800 to 2500 million-year-old Bulawayan Sherpasliving permanentlyat high altitude:Pattern of adaptation,747 stromatolite: Ultramicrochemical analyses, 2973 Sialic acid Scatteringtheory Humanalpha-fetoprotein as modulatorof humanlymphocyte Inverse problem for convex bodies, 1377 transformation:Correlation of biologicalpotency with electrophoretic Schizophrenia variants,4645 Dopamine receptors in human and calf brains, using [3H]apomorphine Sialyltransferase(EC 2.4.99.1) and an antipsychotic drug, 4354 Alterationsin surfaceglycoproteins and level of sialyltransferaseof cells Schlemmcanal transformedby temperature-sensitivemutant of simian virus 40, 4090 Blood-aqueous barrier can be circumvented by lowering intraocular ConcanavalinA affects expressionof cell surfacesialyltransferase pressure, 638 activity of mouse thymocytes,837 Schmidt-Ruppin Rous sarcoma virus Sickle cell disease Location of envelope-specific and sarcoma-specific oligonucleotides on Dichloromethaneas antisicklingagent in sickle cell hemoglobin,4195 RNA of Schmidt-Ruppin Rous sarcoma virus, 447 Inhibitionof erythrocytesickling by cystamine,a thiol reagent,3288 Scorpiontoxin Supersaturationin sickle cell hemoglobinsolutions, 3035 Membrane potential dependent binding of scorpion toxin to action Sickle cell hemoglobin potential Na+ ionophore, 2682 see HemoglobinS Scurvy Sigma factor Gene for L-gulono--y-lactone oxidase is not expressed in animals subject Inductionof sigma factorsynthesis in Escherichiacoli by the N gene to scurvy: Immunologic evidence, 2066 productof bacteriophagelambda, 4405 Sea anemone Putative sigma factor from Chlamydomonasreinhardi: Purification and see Anemonia sulcata characterization,3961 Sea snake Specific bindingof formylatedinitiator-tRNA to Escherichiacoli RNA see Laticauda semifasciata polymerase,3064 Sea urchin Simianvirus 40 see Lytechinus pictus Alterationsin surfaceglycoproteins and level of sialyltransferaseof cells Seawateradaptation transformedby temperature-sensitivemutant of simian virus 40, 4090 Eel esophagus as osmoregulatory organ, 1348 Autoregulationof simian virus 40 gene A by T antigen,3083 Sedimentationequilibrium Biochemicalmapping of eukaryoticviral DNA by linked Somatostatin conformation: Stable intramolecular structure by circular transcription-translationcell-free system, 2747 dichroism, diffusion, and sedimentation equilibrium, 1199 Constructionand proparationof defectivesimian virus 40 genome Sediment transport bearing .1m'm rm,r 111ini>; ,t'(riophage X, 1068 Bedload measurements, East Fork River, Wyoming, 1000 Deficiencyin histone acetylationin nontransforminghost rangemutants Seed plants of polyomavirus, 1092 Rates of evolution in seed plants: Net increase in diversity of Determinationof numberof superhelicalturns in simian virus 40 DNA chromosome numbers and species numbers through time, 2086 by gel electrophoresis(correction), 2527 Segregation DNA-relaxingactivity and endonucleaseactivity in Xenopus laevis Heredity of Gix thymocyte antigen associated with murine leukemia oocytes, 4551 virus: Segregation data simulating genetic linkage, 2077 "Early"simian-virus-40-specific RNA containsinformation for tumor Selenium antigen formationand chromatinreplication, 366 Selenium: Essential trace nutrient for growth of WI-38 diploid human Integratedsimian virus 40 sequencesin transformedcell DNA: Analysis fibroblasts, 2023 using restrictionendonucleases, 1102 Selenium regulation of hepatic heme metabolism: Induction of Intermediatewith single-strandbreak in reactioncatalyzed by DNA 5-aminolevulinate synthase and heme oxygenase, 4428 untwistingenzyme, 3488 Selenoprotein Linkingnumbers and nucleosomes,2639 see also Cysteine, seleno- Monomermolecular weight of T antigen from simian virus 40-infected Chemical characterization of selenoprotein component of clostridial and transformedcells, 2254 glycine reductase: Selenocysteine is the organoselenium moiety, 2659 Nicked DNA-proteincomplex from simian virus 40: Covalent Semiconductor attachmentof proteinto DNA and nick specificity,1945 Path of electrons in photosynthesis, 4502 Regulationof active a-aminoisobutyricacid transportexpressed in Semliki Forest virus membranevesicles from mouse fibroblasts,2614 Initiation of translation directed by 42S and 26S RNAs from Semliki Regulationof guanylateand adenylatecyclase activities by lysolecithin, Forest virus in vitro, 3059 1586 Sequential translation of nonstructural proteins in cells infected with Resting state in normaland simian virus 40 transformedChinese Semliki Forest virus mutant, 1936 hamsterlung cells, 1655 Sendai virus Segmentof simian virus 40 genomecontaining origin of DNA replication: Transfer of tRNAs to somatic cells mediated by Sendai-virus-induced Isolationand propagation,1513 fusion, 2793 Simian virus 40 DNA: In vitro replicationin nucleoproteincomplex, Virus and lectin agglutination of erythrocytes: Spin label study of 3466 membrane lipid-protein interactions, 3497 Simian-virus-40-specificT-antigen: Two formsin abortiveand lytic Sensory coding infection, 1097 Anesthetic stimulation of insect water receptors, 3315 Simian virus 40 tumor-specificproteins in nucleus and plasma Sequence-specific recognition membraneof HeLa cells infected by adenovirus2-SV40 hybridvirus Sequence-specific recognition of double helical nucleic acids by proteins, Ad2+ND2, 2505 804 Sodium-stimulatedamino acid uptake into isolated membranevesicles Serine endopeptidase from Balb/c 3T3 cells transformedby simian virus 40, 1631 Homologous inhibitors from potato tubers of serine endopeptidases and Sodium-stimulatedna-aminoisobutyric acid transportby membrane metallocarboxypeptidases, 1941 vesicles from simian virus-transformedmouse cells, 1907 Serine hydroxymethyltransferase (EC 2.1.2.1) Subnuclearsystems for synthesisof simian virus 40 DNA in vitro, 4392 Teta-hv-drofol,te: Coonertrive interaction with pig kidney serine Viraltranscription and tumorantigen expressionregulated in cells 1:';11.:!'.nl,'t \ I-|\ui::i1.- <(l loss of cooperativity in L1210 tumors and transformed by simian virus 40, 1931 in tissues of mice bearing these tumors, 1950 Xenopus laevis oocyte extract affects supercoiled simian virus 40 DNA: Serine proteinases Formation of complex DNA, 554 Molecular orbital studies of enzyme activity: Catalytic mechanism of Sindbis virus serine proteinases, 432 Enveloped virus acquires membrane defect when passaged in fibroblasts Serinol from I-cell disease patients, 2443 Serinol as an activator of toxin production in attenuated cultures of Slime mold Helminthosporium sacchari, 4007 see Dictyostelium discoideum; Physarum polycephalum; Serology Polysphondylium violaceum Cell surface antigens of human malignant melanoma: Mixed Smooth curve hemadsorption assays for humoral immunity to cultured autologous Maximal functions associated to smooth curves, 4295 melanoma cells, 3278 Snake venom Three-dimensional structure of erabutoxin b neurotoxic protein: Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4773

Inhibitor of acetylcholine receptor, 2991 Speciation Sodium Rates of evolutionin seed plants:Net increasein diversityof Development of action potential mechanism of amphibian neurons chromosomenumbers and species numbersthrough time, 2086 isolated in culture, 1641 Rates, patterns,and effectivenessof evolutionin multi-levelsituations, Free acid, anion, alkali, and alkaline earth complexes of lasalocid A 1360 (X537A) in methanol: Structural and kinetic studies at monomer level, Species-distancerelation for birds of SolomonArchipelago, and paradox 4277 of great speciators,2160 Sodium-stimulated amino acid uptake into isolated membrane vesicles Species-area-distancerelation from Balb/c 3T3 cells transformed by simian virus 40, 1631 Calculationof immigrationand extinctioncurves from Temperature dependence of four ionic processes of spike electrogenesis species-area-distancerelation, 4130 in eel electroplaques, 3554 Spectrin Transient change in Na ion conductivity of excitable membranes, 4492 Asynchronoussynthesis of erythrocytemembrane proteins, 3206 Sodium gradient Reconstitutionof intramembraneparticles in recombinantsof Proline and glycine uptake by renal brushborder membrane vesicles, erythrocyteprotein Band 3 and lipid: Effects of spectrin-actin 4521 association,3891 Regulation of active a-aminoisobutyric acid transport expressed in Spermidine membrane vesicles from mouse fibroblasts, 2614 (v-Methylornithine,potent competitiveinhibitor of ornithine Sodium ionophore decarboxylase,blocks proliferation of rat hepatomacells in culture, Membrane potential dependent binding of scorpion toxin to action 1626 poteintial Na+ ionophore, 2682 Protein inhibitorto ornithinedecarboxylase induced by end productsof Pharmacologic characterization of Na+ ionophores in L6 myotubes, 1355 its reaction,1858 Sodium pump Spermine Spike-forming model of neural membrane: Improvement in parameter Protein inhibitorto ornithinedecarboxylase induced by end productsof values, 2264 its reaction,1858 Solanaceae Spermstorage Hybridization of potato spindle tuber viroid to cellular DNA of normal Ethologicalisolation and matingexperience in Drosophilapaulistorum, plants, 2453 975 Solar nebula Sphenodonpunctatus Allende meteorite: Isotopically anomalous xenon is accompanied by Ear and hearingin Sphenodonpunctatus, 4244 normal osmium, 4253 Sphericalmeans Solar spectrum Maximalfunctions: Spherical means, 2174 Solar abundance of iridium, 269 Sphingomyelin SolomonArchipelago, birds of Propertiesof toxin from sea anemoneStoichactis helianthus, including Calculation of immigration and extinction curves from specific bindingto sphingomyelin,467 species-area-distance relation, 4130 Spiders,orb-weaving Species-area relation for birds of Solomon Archipelago, 262 see Argiope;Nephila clavipes Species-distance relation for birds of Solomon Archipelago, and paradox Spike electrogenesis of great speciators, 2160 Temperaturedependence of four ionic processesof spike electrogenesis Solution conformation in eel electroplaques,3554 Lasalocid A (X537A) and its silver, sodium, and barium salts: Structural Spinal cord and kinetic studies in nonpolar solvents, 1786 Centralregulation of sympatheticneuron development, 3575 Solution, dilute Spin-forbiddentransition Resonance enhanced coherent anti-Stokes Raman scattering, 3798 Magneticcircular dichroism of moleculesin dense media:Spin-forbidden Solvent effect transitionsof carbonylmolecules, 2964 Medium-induced radiationless transitions and effect of solvent on Spin label radiationless transitions, 2533 Virusand lectin agglutinationof erythrocytes:Spin label study of Solvent, nonpolar membranelipid-protein interactions, 3497 Conf'ormation of uncomplexed [Phe4,Val6]antamanide crystallized from Spin-labelhapten nonpolar solvents, 1782 Model membranes:Lateral hapten mobilityand immunochemistry,2977 Lasalocid A (X537A) and its silver, sodium, and barium salts: Structural Spiral arm and kinetic studies in nonpolar solvents, 1786 Unstablespiral modes in disk-shapedgalaxies: Enhancement of growth Somaticcell genetics rate, 3785 Heteropolymeric hexosaminidase A in human X mouse hybrid cells, 3637 Spiral mode Two linked human genes cotransferred into cultured mouse cells, 1274 Unstable spiral modes in disk-shapedgalaxies, 1379 Somatic crossing-over Spleen endonuclease(EC 3.1.4.7) Genetic controls of meiotic recombination and somatic DNA metabolism Chromatin-likeorganization of adenoviruschromosome, 401 in Drosophila melanogaster, 4140 Variabilityin DNA repeat length in chromatinof highereukaryotes, Somatomedin 4382 Amino-terminal sequences of two polypeptides from human serum with Spleen phosphodiesterase(EC 3.1.4.18) nonsuppressible insulin-like and cell-growth-promoting activities: Structureat 5'-ends of nascent DNA chains,3438 Structural homology with insulin B chain, 4379 Spongiformvirus encephalopathy Polypeptides with nonsuppressible insulin-like and cell-growth Serial propagationof Creutzfeldt-Jakobdisease in guinea pigs, 223 promoting activities in human serum: Isolation, chemical Spore maturation characterization, and biological properties of forms I and II, 2365 Chromosomalgene requiredfor killer plasmidexpression, mating, and Somatostatin spore maturationin Saccharomycescerevisiae, 2061 Does somatostatin inhibition of insulin secretion involve two Sporulation mechanisms of action? 248 Controlof development:Role of regulatorynucleotides synthesized by Hypertrophy and hyperplasia of somatostatin-containing D-cells in membranesof Bacillus subtilis in initiation of sporulation,331 diabetes, 1338 Photoreceptorpigment that inducesdifferentiation in slime mold Somatostatin conformation: Stable intramolecular structure by circular Physarumpolycephalum, 3896 dichroism, diffusion, and sedimentation equilibrium, 1199 Spreadingdepression Somatotropin Mullercell functionduring spreading depression in frog retina, 1351 Binding of insulin to isolated nuclei, 1427 Squid giant synapse Diabetogenic peptide from human growth hormone: Partial purification Presynapticcalcium currents and relationto synaptictransmission: from peptic digest and long-term action in ob/ob mice, 4706 Voltageclamp study in squid giant synapseand theoreticalmodel for Dose-dependent depletion of nuclear receptors by L-triiodothyronine: calciumgate, 2918 Role in induction of growth hormone synthesis in cultured GH1 cells, Staphylococcalprotein A 3877 Geneticpolymorphism of IgD-likecell surfaceimmunoglobulin in mouse, Gram-preparative protein fractionation by isotachophoresis: Human 1305 growth hormone isohormones isolated, 732 Statistical mechanics Human pituitary growth hormone: Restoration of full biological activity Kinetic theory and ergodicproperties, 1802 by noncovalent interaction of two fragments of hormone, 1476 Statistics Human somatotropin: Biological characterization of recombinant Boundsfor joint distributionfunction with fixed sub-distribution molecule, 3463 functions:Application to competingrisks, 11 Nonsuppressible insulin-like activity and thyroid hormones: Major Maximallydependent random variables, 286 pituitary-dependent sulfation factors for chick embryo cartilage, 2904 Radiationeffects in living cells: Structuralmodel, 3360 Pregrowth hormone: Product of translation in vitro of messenger RNA Statistics, binomial coding for growth hormone, 29 Evokedneurotransmitter release: Statistical effects of nonuniformityand Sex differences in binding of human growth hormone to isolated rat nonstationarity,2913 hepatocytes, 847 Evokedneurotransmitter release: Statistical effects of nonuniformityand Thyroid hormone stimulates de novo growth hormone synthesis in nonstationarity(correction), 3320 cultured GH1 cells: Accumulation of rate limiting RNA species in Stearoyl-CoAdesaturase induction, 3369 Isolationand characterizationof unsaturatedfatty acid-requiringmutant Somatotropinprecursor of culturedmammalian cells, 24 Pregrowth hormone: Product of translation in vitro of messenger RNA Stellacyanin coding for growth hormone, 29 Blue coppercenters in proteins,spectroscopic studies and structural model, 1389 Downloaded by guest on October 5, 2021 4774 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Steroid hormone Synapse formation between clonal neuroblastoma X glioma hybrid cells Inhibitionof arachidonicacid releasefrom cells as biochemicalaction of and striated muscle cells, 123 anti-inflammatorycorticosteroids, 1730 Synaptichyperpolarization Membraneperturbation: Calcium-sensitive dye, arsenazoIII, used in Intraneuronal guanylyl-imidodiphosphate injection mimics long-term liposomes,510 synaptic hyperpolarization in Aplysia, 4689 Steroid hormonesregulate phosphorylation of specific protein common Synaptic transmission to severaltarget organs,568 /3-Bungarotoxin, pre-synaptic toxin with enzymatic activity, 178 Stigma Evoked neurotransmitter release: Statistical effects of nonuniformity and Cell recognitionin plants:Determinants of stigma surfaceand pollen nonstationarity, 2913 interactions,2788 Evoked neurotransmitter release: Statistical effects of nonuniformity and Stochastic competitiontheory nonstationarity (correction), 3320 Competitiveinterdeterminacy in Tribolium,1368 Presynaptic calcium currents and relation to synaptic transmission: Stoichactis helianthus toxin Voltage clamp study in squid giant synapse and theoretical model for Propertiesof toxin from sea anemoneStoichactis helianthus, including calcium gate, 2918 specific bindingto sphingomyelin,467 Synaptogenesis Storagedisease Acetylcholine receptors: Localization during synaptogenesis in retina, Envelopedvirus acquiresmembrane defect when passagedin fibroblasts 1806 from I-cell disease patients, 2443 Synaptosome Strain measure Mechanism of action of (-bungarotoxin on synaptosomal preparations, Soft polymers:Time-dependent response in moderatelylarge 2664 deformations,981 Triiodothyronine localized in nerve ending fractions of rat brain, 941 Stringentfactor Synchrotronradiation Ribosomalproteins of Escherichiacoli that stimulate Applications of synchrotron radiation to protein crystallography, 128 .tr:n:rcnt rfactr rmcd:ated pyrophosphoryl transfer in vitro, 1839 Synchrotronspectroscopy ii::I t.',ti lit-:n/t.n-.: .'. --richia coli directs ribosomal binding and Extended x-ray-absorption fine structure-Auger process for surface releaseof unchargedtRNA, 0707 structure analysis: Proposed experiment, 2550 Subacutesclerosing panencephalitis Synthesis,cell-free Measlesvirus-specific IgD antibodiesin patients with subacute Synthesis of polypeptides with properties of myosin light chains directed sclerosingpanencephalitis, 1297 by RNA extracted from muscle cultures, 4599 Substrateconformation Systemic lupus erythematosus,human Conformationalproperties of ribavirin,4257 Antigen related to mammalian type-C RNA viral p30 proteins is located RibonucleaseP substratespecificity: Cleavage of bacteriophage in renal glomeruli in human systemic lupus erythematosus, 233 ?i80-inducedRNA, 1912 Substratecontrol Controlof oscillatingglycolysis of yeast by stochasticperiodic, and T-antigen steady source of substrate:A model and experimentalstudy see Antigen, tumor (correction),661 Tate cohomology Subtilisin High dimensional cohomology of discrete groups, 1795 Conformationalflexibility and proteinfolding: Rigid structural Tau factor fragmentsconnected by flexiblejoints in subtilisin BPN, 1974 Polycation-induced assembly of purified tubulin, 2813 Succinoxidase Tubulin requires tau for growth onto microtubule initiating sites, 4070 Bioenergeticsin clinicalmedicine: Prevention by forms of coenzymeQ of Technetium inhibitionby adriamycinof coenzymeQlo-enzymes in mitochondriaof Structural characterization of bridged 99Tc-Sn-dimethylglyoxime myocardium,4653 complex: Chemistry of 99mTc-radiopharmaceuticals prepared by Sn(II) Sugar reduction of pertechnetate, 4287 Sugarsaffect early biochemicalevents in developmentof Dictyostelium Teichmuller space discoideum,3183 Completeness of Bergman metric and its subordinate metric, 4294 Sugaruptake Tentoxin Structureof L-arabinose-bindingprotein from Escherichiacoli at 5 A Chloroplast coupling factor 1: Species-specific receptor for tentoxin, 2245 resolutionand preliminaryresults at 3.5 A, 2186 Testicularfeminization Sulfated proteoglycans Androgen insensitivity in man: Genetic heterogeneity, 891 Sulfated proteoglycanssynthesized in nonchondrogeniccells, Tissue interaction in androgen response of embryonic mammary presumptivechondroblasts, and chondroblasts,3224 rudiment of mouse: Identification of target tissue for testosterone, Sulfatide 4041 Phagosome-lysosomefusion in culturedmacrophages prevented by Testosterone sulfatides of Mycobacteriumtuberculosis, 2510 Control of renal vitamin D hydroxylases in birds by sex hormones, 2701 Sulfation factor Tissue interaction in androgen response of embryonic mammary Nonsuppressibleinsulin-like activity and thyroid hormones:Major rudiment of mouse: Identification of target tissue for testosterone, pituitary-dependentsulfation factorsfor chick embryocartilage, 2904 4041 Sulfhydrylreactivity Tetanus toxoid Interactionof integraland peripheralmembrane proteins: Affinity Isoimmunization against human chorionic gonadotropin with conjugates labelingof yeast cytochromeoxidase by modifiedyeast cytochromec, of processed (-subunit of hormone and tetanus toxoid, 218 4334 Tetracyanoquinodemethane Sulfurbinding Conductivity and structure of bilinear organic addition compounds, 3820 Platinum binds selectivelyto phosphorothioategroups in mono- and Tetracycline polynucleotides:General method for heavy metal staining of specific Synthesis of R plasmid protein associated with tetracycline resistance is nucleotides,2536 negatively regulated, 1509 Sun Tetrahydrofolate Solar abundanceof osmium, 1382 Tetrahydrofolate: Cooperative interaction with pig kidney serine Superheavyelements transhydroxymethylase and loss of cooperativity in L1210 tumors and Allende meteorite:Isotopically anomalous xenon is accompaniedby in tissues of mice bearing these tumors, 1950 normalosmium, 4253 Tetrahydropteroylglutamatetransferase (EC 2.1.9.13) Suppression In viuvorates of methionine biosynthesis in transformed human and Transferof tRNAs to somaticcells mediatedby Sendai-virus-induced malignant rat cells auxotrophic for methionine, 1523 fusion, 2793 Tetrahymenapyriformis Surfacebinding site Homozygous mutants isolated after induced self-fertilization in Human lymphocytestimulation by concanavalinA: Role of valenceand Tetrahymena, 3243 surfacebinding sites, 2118 Tetraphosphatedetermination Surfacemodulating assembly Primary transcripts in Ehrlich ascites cells measured by tetraphosphate Temperature-sensitivechanges in surfacemodulating assemblies of determination, 1994 fibroblaststransformed by mutants of Rous sarcomavirus, 2047 Tetrathiafulvalene Surfacestructure analysis Conductivity and structure of bilinear organic addition compounds, 3820 Extendedx-ray-absorption fine structure-Auger processfor surface Tetrodotoxin structureanalysis: Proposed experiment, 2550 Pharmacologic characterization of Na+ ionophores in L6 myotubes, 1355 Surfacetension Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells, 2520 Direct determination of surface tension in lung, 4698 a-Thalassemia Survival,differential Trimodality in proportion of hemoglobin G Philadelphia in Darwin's finches: Population variation and natural selection, 257 heterozygotes: Heterogeneity in number of human alpha chain loci, Survivalfunction 3633 Bounds for joint distribution function with fixed sub-distribution Theophylline functions: Application to competing risks, 11 Adenosine 3':5'-cyclic monophosphate deficiency in Neurospora crassa, Symbiont, nodulated 2995 Hydrogen evolution affects efficiency of nitrogen fixation in nodulated Interactions between nutritional factors and drug biotransformations in symbionts, 1207 man, 2501 Symmetricspaces Thermaldenaturation Maximal functions: Poisson integrals on symmetric spaces, 2547 Viroids are single-stranded covalently closed circular RNA molecules Synapse formation existing as highly base-paired rod-like structures, 3852 Specificity of synapse formation, 3544 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4775

Thermodynamic fluctuation Tomato 'l'hermodyniamic fluctuations in protein molecutles, 2740 see l,ycopersicon Thermodynamics Tonofilament ('aloritnitric studies of in Litro polymerization of })rain tubulin, 3565 Immuinological characterization of subunit of 100 A filaments from C I l)nl muonoxidebinding to pentacoordinalte mercaptide-heme muscle cells, 4:344 complexes: Kinetic stutdy on models for cytochrome P'-450, 3338 Topological dynamics Thioester Relativized problems with abelian phase group) in topological dynamics, 2-I)iazo-:3,:3,:3-trifluoropropionylchloride: Reagent for photouaf'finity 1007 labeling, 1406 Torpedo californica Thioesterase Plhotoaffinity labeling an(d quaternary structure of acetylcholine receptor Specific release of thioesterase component of fatty acid synthetase ft'romTorpedo californica, 2624 mutiltienzymecomplex by limited trypsinization, 1184 Toxin Thiol, reactive see also Biniding site, toxin; Scorpion toxin Reciprocal reactivities of specific thiols when actin binds to myosin, 302 Serinol as anl activator of' toxin production in attenuated cultures of Thiophosphoric acid thioesters Helminthosporium sacchari, 4007 Alkaline phosphatase activity in lymphocyte, mitogen-induced blasts, Toxin, presynaptic lymphoblastoid cell linies, acutte myeloid letukemia, and chronic ;-Bungarotoxin, pre-synaptic toxin with enzymatic activity, 178 lymphatic letikemia cells, 1432 Toxin, sea anemone Thioredoxin Sea aniemone toxin: Molecular mechanisms of nierve cotnduictionand E,'scherichiacoli thioredoxin: Su)bunit of bacteriophage T7 I)NA excitationi-secretionl coutipling,4055 polymerase, 780 Trace metal nutrition Hydrogen donuorsystem for Escherichia coi ril)onutlccoside-diphosphate Copper-induced activation of aortic lysyl oxidase in vivo, 371 redtictase dependent upon gluttathione, 2275 Trace nutrient Thrombin Selenitum: Essential trace nutrient for growth of WI-38 diploid human see also P'reprothrombin; Prothrombin fibroblasts, 202:3 active fuormsof thrombin: Binding to platelets and effects on Transcription Multiple 1518 platelet function, 1660 L-Arabinose operon: Electron microscopy of gene regulation, Thrombogenesis Bacteriophage T4 gene whose product prevents true late transcription on Antagonism of 5-hydroxykynurenamine against serotonin action on cytosine-containiing T4 I)NA, :1098 a platelet aggregatioun,643: Conversion of Bacillus subtilis RNA polymerase activity in vitro by Thymidine protein induced by phage SPOI (correction), 661 5-Bromodeoxyturidinie and thymidine distribution in l)NA of developing I)eletions of lambda phage locating a prm mutation within rightward chick cartilage, 1019 operator, 712 Thymidine kinase (EC 2.7.1.75) Euglena chloroplast tRNAs: I'ranscriptional origin, 1984 Initracellutlarlocalization of moutiseI)NA polymerase-(o, 11:136 Iniduction of sigma factor synthesis in Escherichia coli by the N gene T'I'wolinked hutman genes cotransferred into cultured moutsecells, 1274 product of bacteriophage lambda, 4405 Thymidylate synthetase Molecular structure of yeast RNA polymerase III: Tripartite Amino acid sequence at FdUMP bindinig site of thymidylate synthetase, transcriptive system in lower eukaryotes, 1024 1848 Nucleotide sequmenceof region preceding trp mRNA iniitiation site and Thymine dimer excision role in promoter anid operator function, 2:351 I)efective thymine dimer excision by cell-free extracts of xeroderma Numcleotidesequences beyond sites of transcriptional termination, 717 pigmentosum cells, 2757 Rlegulation of transcription factor p and sutbunit of RNA polymerase in Thymocyte fscherichia coli B/r, 2285 Anitibody-producing cells: Virus-induced alteration of response to Selective digestion of transcriptionally active ovalbumin genes from antigen, 1707 oviduct nuclei, :13966 (Concanavalin A affects expression of cell surface sialyltransferase Specific )inding of formylated initiator-tRNA to Escherichia coli RNA activity of mouse thymocytes, 837 polymerase, :13064 Thymus Transcription in vitro of chromatin in presence of mercurated Abnormal response to minor histocompatihility antigens in Obese strain mnucleotide,1564 chickens, 2877 lranscription in vitro of immunioglobulin kappa light chain genes in Anitibody-produicing cells: Virus-induced alteration of response to isolated mouse myeloma niuclei and chromatin, 775 anitigenl, 1707 Transcription in yeast: (Y-Amanitin sensitivity and other properties Changes in expression of murinle leukemia virus antigens and production which distinguish between RNA polymerases I anid III, 1029 of xenotropic virus in the late preletikemic period in AKR mice, 4680 Viral transcription and tumor antigen expression regulated in cells Thyroid transf'ormed by simian virus 40, 19:31 Cholera toxin interactions with thyrotropin receptors on thyroid plasma Transcriptional derepression membranes, 1679 Induction otf mouse type-C virus by translational inhibitors: Thyroid hormone 'ranscriptional derepression of specific class of endogenous virus, 4541 see Triiodothyronine Transcription-translation cell-free system Thyroiditis Biochemical mapping of eukaryotic viral DNA by linked Abnormal response to minor histocompatibility antigens in Obese strain transcription-traniislation cell-free system, 2747 chickens, 2877 Transduction Thyroid stimulating hormone Specialized transduction of colicin El I)NA in Escherichia coli K-12 by see Thyrotropin phage lambda, .3238 Thyrotropin Transformation Binidinigof' insutlin to isolated nuclei, 1427 Expression of thymidylate synthetase gene of Bacillus subtilis Cholera toxin interactions with thyrotropin receptors on thyroid plasma bacteriophage Phi-3-T in Escherichia coli, 4145 membranes, 1679 I,ocalization of gene functions in polyoma virus I)NA, 4169 Relationship of gangliosides to structutre and function of thyrotropin Transformation of cells, chemical receptors: Their absence on plasma membranes of thyroid tumor Control of growth of benzola]pyrene-transformed 3T3 cells, :3229 (ef'ective in thyrotropin receptor activity, 4060 D)imethylsulfoxide-induced differentiation and hemoglobin synthesis in Ihyrotropin and cholera toxin uised to probe mechanism by which tissue cultures of rat erythroleukemia cells transf'ormed by interferonl initiates antiviral activity, 3695 7,12-dimethyllenz(a)anthracene, 1237 Thyvrotropin-ganglioside interactions and relationship to structure and Inihibitory effect of human alpha-fetoprotein on in vitro transformation fu'nction of thyrotropin receptors, 842 oft hutman lymphocytes, 2857 Tin Prevention otf viral-chemical co-carcinogenesis in vitro by type-specific Structural characterization of bridged :':)Tc-Sn-dimethylglyoxime aniti-viral antibody, 152 complex: Chemistry of'u')imTl'c-radiopharmaceuticals prepared by Snl(II) Transformation of cells, viral reduction oufpertechnetate, 4287 Alterations in surface glycoproteins and level of sialyltransferase of cells Tissue, cubic transformed by temperature-sensitive mutant of simian virus 40, 4090 Anialogue solution for electrical capacity of membrane-covered cubes in Cell surface protein partially restores morphology, adhesiveness, and cufbic array at high concenitration, 400:3 contact inhibition of movement to transformed fibroblasts, 1217 Tissue culture D)eficiency in histone acetylation in nontransforming host range mutants Cell suLrfaceantigens of human malignant melanoma: Mixed of polyoma viruts, 1092 hemadsorptionmassays for humoral immuinity to cumltturedauitologous D)ifferent calcium requirements for proliferation of conditionally and melanoma cells, 3278 unconditionally tumorigenic mouse cells, 1651 Tissue transplant I)ifferential effect of phosphonoacetic acid on expression of Growth of transplanted tails of infant rats in adolescent allogeneic Epsteiln Barr viral antigens and virus productionl, 1745 recip)ients, 3283 I)NA methylation in adenovirus, adenovirus-transf'ormed cells, and host T-lymphocyte (ells, :3923 see I,ympho(cyte, thymus-derived Integrated simian virus 40(sequences in transformed (:ell DNA: Analysis Tobacco mosaic virus using restriction endonucleases, 11(02 Inlcorporation of 5-fluorocytidine in RNA oft 5-fluorouracil-trcated In -ivi'orates of methionine biosynthesis in transformed human and eukaryotic cells, 1528 malignant rat cells auxotrophic for methionine, 1523 Tolerance Mic rofilament organization and surface topography: Changes upon Ontolgeny of mouse B lymphocytes and inactivation by antigen of early B transformation of chick embryo fibroblasts with Rous sarcoma virus, lymphocytes, 2462 4165i Downloaded by guest on October 5, 2021 4776 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

Monomer molecular weight of T antigen from simian virus 40-infected Sodium-stimulated amino acid uptake into isolated membrane vesicles and transformed cells, 2254 from Balb/c 3T3 cells transformed by simian virus 40, 1631 Regulation of active cv-aminoisobutyric acid transport expressed in Transport, a-aminoisobutyric acid membrane vesicles from mouse fibroblasts, 2614 Regulation of active a(-aminoisobutyric acid transport expressed in Regulation of guanylate and adenylate cyclase activities by lysolecithin, membrane vesicles from mouse fibroblasts, 2614 1586 Sodium-stimulated oa-aminoisobutyric acid transport by membrane Resting state in normal and simian virus 40 transformed Chinese vesicles from simian virus-transformed mouse cells, 1907 hamster lung cells, 1655 Transport, cation Reversion from transformed to normal phenotype by inhibition of Stoichiometric relationship between energy-dependent proton ejection protein synthesis in rat kidney cells infected with and electron transport in mitochondria, 437 temperature-sensitive mutant of Rous sarcoma virus, 3603 Transport, electron Rous-sarcoma-virus-transformed fibroblasts having low levels of Restoration of oxidative phosphorylation by purified plasminogen activator, 3613 N,N'-dicyclohexylcarbodiimide-sensitive latent Sodium-stimulated amino acid uptake into isolated membrane vesicles adenosinetriphosphatase from Mycobacterium phlei, 3050 from Balb/c 3T3 cells transformed by simian virus 40, 1631 Stoichiometric relationship between energy-dependent proton ejection Sodium-stimulated aY-aminoisobutyricacid transport by membrane and electron transport in mitochondria, 437 vesicles from simian virus-transformed mouse cells, 1907 Transport, glucose Tcmnrrrat"<:r ^ -^it:ve in surface assemblies of Effect of AMP on in rat 4359 ? changes modulating 3':5'-cyclic glucose transport adipocytes, ,i ,'- .-- ',..!-i?,?..: tby mutants of Rous sarcoma virus, 2047 Reconstitution of I)-glucose transport catalyzed by protein fraction from 'fTumorinduction and large external transformation sensitive protein on human erythrocytes in sonicated liposomes, 396 cell surface, 3570 Transport, histidine Viral transcription and tumor antigen expression regulated in cells Protein-protein interaction in transport: Periplasmic histidine-binding transformed by simian virus 40, 1931 protein J interacts with P protein, 1.877 Transglutaminase Transport, hormone Elimination of rotating carrier mechanism for active transport of Ca ion Localization of phytochrome in etioplasts and its regulation in vitro of in sarcoplasmic reticulum membranes, 1532 gibberellin levels, 138 Intrinsic transglutaminase in Ca'+-mediated crosslinking of erythrocyte Transport, hydrogen proteins, 4479 Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate Transition metal reductase dependent upon glutathione, 2275 Correlation of nonorthogonality of best hybrid bond orbitals with bond Transport, ion strength of' orthogonal orbitals, 274 Membrane potential dependent binding of scorpion toxin to action Transition-state rate theory potential Na+ ionophore, 2682 Diffusion frequency factors in some simple examples of transition-state Transport, lipoprotein rate theory, 679 Apolipoproteins in rat serum and renal lymph, 1757 Translation Transport, maltose Chick cytoplasmic actin and muscle actin have different structural genes, (-Galactosidase converted to membrane-bound state by gene fusion, 2346 3423 Competition between cellular and viral mRNAs in vitro is regulated by Transport, phosphate messenger discriminatory initiation factor, 3040 Erythrocyte phosphate transport inhibited by high pressures, 2767 I)ifferential degradation of messenger RNAs in mammalian cells, 2634 Hypophosphatemia: Mouse model for human familial hypophosphatemic Evolution of universal genetic code, 2336 (vitamin D-resistant) rickets, 4667 Initiation of translation directed by 42S and 26S RNAs from Semliki Stoichiometric relationship between energy-dependent proton ejection Forest virus in vitro, 3059 and electron transport in mitochondria, 437 Large product of cell-free translation of messenger RNA coding for Transport regulation corticotropin, 4319 Paradoxical effects of cycloheximide and cytochalasin B on hamster cell Mammalian messenger RNA lacking polyadenylate segment, 3088 hexose uptake, 2429 Specific binding of formylated initiator-tRNA to Escherichia coli RNA Transport system polymerase, 3064 Structure of L-arabinose-binding protein from Escherichia coli at 5 A Translation of nonpolyadenylylated messenger RNA of sea urchin resolution and preliminary results at 3.5 A, 2186 embryos, 148 Transport, transepithelial Translational control Transepithelial transport in cell culture, 1212 Iniduction of vitellogenin synthesis by estrogen in avian liver: Transversion Relationship between level of vitellogenin mRNA and vitellogenin Heat mutagenesis in bacteriophage T4: Transversion pathway, 4159 synthesis. 1442 Tribolium Protein kinase activity associated with hemin-controlled repressor of Competitive interdeterminacy in Tribolium, 1368 rabbit reticulocyte, 3078 Tribolium castaneum Protein synthesis in reticulocyte lysates: Effects of 3':5'-cyclic AMP, Group selection among laboratory populations of Tribolium castaneum, ATP, and GTP on inhibitions induced by heme-deficiency, 4604 double-stranded RNA, and a reticulocyte translational inhibitor, 1112 Trifluorodiazoethane Translational heterogeneity 2-Diazo-3,3,3-trifluoropropionyl chloride: Reagent for photoaffinity Nitrofurans, a group of synthetic antibiotics, with a new mode of action: labeling, 1406 Discrimination of specific messenger RNA classes, 3386 Trigeminal system Translational inhibitor Opiate and stimulus-produced analgesia: Functional anatomy of Iniduction of mouse type-C virus by translational inhibitors: medullospinal pathway, 4685 Transcriptional derepression of specific class of endogenous virus, 4541 Triglyceride Protein synthesis in rabbit reticulocyte lysates: Inhibition of protein Conversion of 3T3 fibroblasts into adipose cells: Triggering of synthesis by translational inhibitor from heme-deficient lysates and differentiation by prostaglandin F^, and 1-methyl-3-isobutyl xanthine, relationship to initiation factor that binds Met-tRNAf, 2720 4516 Protein synthesis in reticulocyte lysates: Phosphorylation of Genetic variation in serum low density lipoproteins and lipid levels in methionyl-tRNAf binding factor by protein kinase activity of man, 937 translational inhibitor isolated from heme-deficient lysates, 3112 Trigoniacea Translational regulation Characterization of 80-million-year-old mollusk shell proteins, 2541 Mechanism of delayed inhibition of protein synthesis in heme-deficient Trihexosyl ceramide rabbit reticulocyte lysates, 3506 Glycosphingolipid content of human pk and p erythrocytes, 3263 Translation, sequential Triiodothyronine Sequential translation of nonstructural proteins in cells infected with Cultured tumor cells: Affinity isolation by drugs and hormones Semliki Forest virus mutant, 1936 covalently bound to glass and Sepharose beads, 2013 Transpeptidation Dose-dependent depletion of nuclear receptors by L-triiodothyronine: Hydrolysis and transpeptidation of peptide substrates by acetyl-pepsin, Role in induction of growth hormone synthesis in cultured GHi cells, '3915 :3877 Transphosphorylation Nonsuppressible insulin-like activity and thyroid hormones: Major 3-Phosphohistidine isolated from phosphorylated pyruvate, phosphate pituitary-dependent sulfation factors for chick embryo cartilage, 2904 dikinase, 4415 Thyroid hormone stimulates de novo growth hormone synthesis in Transport, active cultured GH1 cells: Accumulation of rate limiting RNA species in Electrochemical gradient of protons and its relationship to active induction, 3369 transport in Escherichia coli membrane vesicles, 1892 Triiodothyronine localized in nerve ending fractions of rat brain, 941 Elimination of rotating carrier mechanism for active transport of Ca ion Trimethylpsoralen in sarcoplasmic reticulum membranes, 1532 Electron microscopy of DNA crosslinked with trimethylpsoralen: Energy-dependent binding of dansylgalactoside to lac carrier protein: Secondary structure of eukaryotic inverted repeat sequences, 2644 Direct binding measurements, 109 Psoralen-crosslinked secondary structure map of single-stranded virus Free energy levels and entropy production associated with biochemical DNA, 2649 kinetic diagrams, 95 Trinitrophenyl-derivatized target cell Transport, amino-acid Cell-mediated cytolysis of trinitrophenyl-derivatized target cells Glutathione and -y-glutamyl cycle enzymes in crypt and villus tip cells of inhibited by alloantisera directed to products of K and D loci of the rat jejunal mucosa, 420 H-2 complex, 625 Induction and decay of glucagon-induced amino acid transport in Triphenylmethylphosphonium ion primary cultures of adult rat liver cells: Paradoxical effects of Change in membrane potential during bacterial chemotaxis, 4387 cycloheximide and puromycin, 4511 Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4777

Triticum aestivum L. Simultaneous detection of reverse transcriptase and high molecular (;liadin protein components: Relationship to chromosomes in hexaploid weight RNA in tissue of patients with Hodgkin's disease and in human wheats (Triticum aestiVum I,.), :3646 patients with leukemia, 4649 Triton X-100 Tumorvirus, avian Binding of' Triton X-100 to diphtheria toxin, crossreacting material 45, Envelope-specific and sarcoma-specific nucleotide sequences from iand their fragments, 4449 dif'feremntparents in RNAs of avian tumor virus recombinants, 107:3 Tropomyosin Tumorvirus, murinemammary Intramolecular crosslinking ot'ftropomyosin via disulfide bond formation: Plasma levels of viral protein as diagnostic signal for presence of tumor: Evidenice for chain register (correction), 2527 Murine mammary tumor model, 4190 Neuirofilament protein localized in neuroblastoma cells by Tumorvolume change immunmofluorescentstaining, 3:1192 Solid tumor models for assessment of different treatment modalities: Tropomyosin-binding componenlt of rabbit skeletal muscle troponimn: Systematics of response to radiotherapy and chemotherapy, 818 Amino-acid sequience, 1902 Turnipyellow mosaicvirus Tropomyosin-binding component of rabbit skeletal muscle troponin: 'l'ranslation of turnip yellow mosaic virus RNA in vitro: A closed and an Amino-acid sequence (correction), 4711 open coat protein cistron, 4437 Troponin C-like protein Type C virus Calcium-dependent regulatory protein of cyclic niucleotide metabolism in see C-type virus normal and transf'ormed chicken embryo fibroblasts, 2711 Tyrosineaminotransferase (EC 2.6.1.5) Troponin, rabbit skeletal muscle I)ifferential degradation of messenger RNAs in mammalian cells, 2634 'I'ropomyosin-binding component of rabbit skeletal muscle troponin: Tyrosine, 3-fluoro- Amino-acid sequmence,1902 lac repressor: 3-Fluorotyrosine substitution for nuclear magnetic T'I'ropomyosin-bindingcomponent of rabbit skeletal muscle troponin: resonance studies, 3471 Amino-acid sequence (correction), 4711 Tyrosine hydroxylase Trypanosoma lewisi see Tyrosine 3-monooxygenase Immunologic and fine structure evidence of avidly bound host serum Tyrosine3-monooxygenase (EC 1.14.16.2) proteins in surface coat of bloodstream trypanosome, 1222 Activation and nuclear translocation of protein kinase during Trypsin transsynaptic induction of tyrosine 3-monooxygenase, 1058 ATP binding to protease-resistant core of actin, 2742 Central regulation of sympathetic neuron development, 3575 Molecutlar abnormality of human alphal-antitrypsin variant (Pi-ZZ) associated with plasma activity deficiency, 1324 Tryptophan Ubiquinone Fluorescence-detected magnetic circular dichroism of fluorescent and Bioenergetics in clinical medicine: Prevention by forms of coenzyme Q of nonfluorescent molecules, 276 inhibition by adriamycin of coenzyme Qlo-enzymes in mitochondria of Nucleotide sequence of region preceding trp mRNA initiation site and myocardium, 4653 role in promoter and operator function, 2351 UDPglucuronyltransferase(EC 2.4.1.17) Tubulin Defective function of microsomal UDP-glucuronyltransferase in Gunn see also Antibody, tubulin rats, 289 Antisera against electrophoretically purified tubulin stimulate Umbilicalcord serum colchicine-binding activity, 1246 Purification of folate binding factor in normal umbilical cord serum, Biochemistry of filaments of brain, 529 2527 Brain tubulin polymerization in absence of microtubule associated Uncertaintyprinciple proteins, 4:397 Lifetime-width relation for a decaying state and the uncertainty Calorimetric studies of in vitro polymerization of brain tubulin, :3565 principle, 283 Enhanced labeling of retinal protein during regeneration of optic nerve Uncoupling in goldfish, 828 tJncoupling in mitochondria: Uncouplers as ionophores for cycling Neurofilament protein localized in neutroblastoma cells by cations and protons, 3141 immunof'luorescent staining, 3192 Unitaryrepresentation Polycation-induced assembly of purified tubulin, 2813 Classification of irreducible tempered representations of semisimple Lie Reversible in vitro polymerization of tubulin from cultured cell clone groups, 2178 (rat glial cell clone C6), 1227 Uranylacetate Secretion of macrophage neutral proteinase enhanced by colchicine, 872 Assay of ribonuclease H, endoribonucleases, and phosphatases, 1556 'tlbillin a_gregation and disaggregation: Mediation by two distinct Assay of ribonuclease H, endoribonucleases, and phosphatases iii,l;?-li. i(hildmli:.:sites, 2375 (correction), 471 1 Tubulin requires tau foirgrowth onto microtubule initiating sites, 4070 Urea cycle Tubulin synthesis in islets of Langerhans, 3188 Abnormal ornithine carbamoyltransferase in mice having sparse-fur Tumor mutation, 1693 see also Cell culture, tumor Uridine2':3'-cyclic phosphorothioate Tumor, animal Stereochemistry of polymerization by DNA-dependent RNA polymerase AKR-specific sequences increased in tumor tissues of leukemic AKR from Escherichia coli: Use of diastereomeric ATP-analogue, 2987 mice, 2448 Urine, human Inicorporation of adenosine into ATP: Formation of compartmentalized Screening by negative chemical ionization mass spectrometry for ATP, :3122 environmental contamination with toxic residues: Application to Tetrahydrof'olate: Cooperative interaction with pig kidney serine human urines, 1777 transhydroxymethylase and loss of cooperativity in L1210 tumors and Urogonadotropin in tissues of mice bearing these tumors, 1950 Gonadotropin from nonpregnant subjects that has physical, Tumor-host interaction immunological, and biological similarities to human chorionic Rheumatoid factor and tumor-host interaction, 2106 gonadotropin, 2885 Tumor, human Uroisocoproporphyria BK virus DNA occutrs in DNA obtained from certain human tumors, Porphyria variegata and porphyria cutanea tarda in siblings: Chemical 4662 and genetic aspects (Addendum), 1:32:3 D)ohighly oncogenic group A human adenoviruses cause human cancer? Ustilago maydis Anialysis of human tumors for adenovirus 12 transforming I)NA Inmheritanceof killer phenotypes and double-stranded RNA in Ustilago sequences, 4657 maydis, 594 Tumorincidence Uterus Iniflumenceof polyunsaturated fatty acids on survival of skin allografts Alpha-fetoprotein: Major high-affinity estrogen binder in rat uterine and tumor inicidence in mice, 928 cytosols, 1452 Tumorinduction Third amino acid residue of oxytocin is important for action on isolated TI'umorinduction anld large external transformation sensitive protein on rat uterus: Relationship between hormone conformation and activity, cell surface, :3570 :3054 Tumor, murinemammary Plasma levels of viral protein as diagnostic signal for presence of tumor: MuLrimnemammary tumor model, 4190 Vaccine, hepatitis B Tumornecrosis factor Hepatitis B vaccine trial, study design, 955 Partial purification of serum factor that causes necrosis of tumors, 381 Vaccine, influenza virus Tumor,plant Chromatographic isolation of hemagglutinin polypeptides from influenza Neoplastic state suppressed with acquisition of specialized funmctionsin virus vaccine and determination of amino-terminal sequences, 2:38 (ells, tissues, and organs of crown gall teratomas of tobacco, 496 Vaccine, oncornavirus Recovery of curown gall tumor cells, 3562 Murine type-C RNA virogenes suppressed by type-specific oncornavirus Tumor therapy vaccines: Prospects for prevention of cancer, 620 Rheumatoid factor and tumor-host interaction, 2106 Valence bond Tumor, thyroid Angles between orthogonal spd bond orbitals with maximum strength, Rlelationship of gangliosides to structure and function of thyrotropin 1403 receptors: Their absence on plasma memb)ranes of thyroid tumor (Correlation of nonorthogonality of best hybrid bond orbitals with bond defective in thyrotropin receptor activity, 40(60 strength of orthogonal orbitals, 274 Tumor virus Metal-metal bond lengths in complexes of transition metals, 4290 see also Ribonucleic acid tumor virus Valinomycin In vivo rates of methionine biosynthesis in transformed human and lPotassium ionophore (valinomycin) inhibits lymphocyte proliferation by malignant rat cells auxotrophic for methioniine, 1523 its effects on cell membrane, :3599 Downloaded by guest on October 5, 2021 4778 Subject Index Proc. Natl. Acad. Sci. USA 73 (1976)

van der Waals theory Vitellogenin van der Waals-type equation of state for fluids with associating Induction of vitellogenin synthesis by estrogen in avian liver: molecules, 1773 Relationship between level of vitellogenin mRNA and vitellogenin Vas deferens synthesis, 1442 Binding of [:H]dihydroazapetine to alpha-adrenoreceptor-related Vitreous body proteins from rat vas deferens, 2730 Synithesis of type II collagen in vitro by embryonic chick neural retina Vasoactive intestinal polypeptide tissue, 4420 Vasoactive intestinal polypeptide localized to central and peripheral Voltage clamp neurons, :3197 Spike-forming model of neural membrane: Computer simulation of Vasopressin additional perfused axon experiments, 100 Fluorometric assay of vasopressin and oxytocin: Assay of peptides in Spike-forming model of neural membrane: Improvement in parameter tissues, 1314 values, 2264 Vector-valued asymptotic martingale lTranisientchange in Na ion conductivity of excitable membranes, 4492 Vector-valued asymptotic martingales, 1798 Voltage clamp study Veratridine Presyniaptic calcium currents and relation to synaptic transmission: Pharmacologic characterization of Na+ ionophores in L6 myotubes, 1355 Voltage clamp study in squid giant synapse and theoretical model for Vertical migration calcium gate, 2918 Photoprotection by carotenoid pigments in copepod Diaptomus nevadensis, 971 Vesicle, coated Walker 256 carcinosarcoma Clathrin: Protein associated with intracellular transfer of membrane by Fetal protein in chromatin of Novikoff hepatoma and Walker 256 coated vesicles, 1255 carcinosarcoma tumors that is absent from normal and regenerating Vesicular stomatitis virus rat liver, 3258 Order of transcription of genes of vesicular stomatitis virus, 442 Wart Sequential transcription of genes of vesicular stomatitis virus, 1504 Human papilloma virus DNA: Physical mapping and genetic Vibrational spectra heterogeneity, 1310 Inielastic electron tunneling spectroscopy of nucleic acid derivatives, 1598 Water permeability Vinblastine Eel esophagus as osmoregulatory organ, 1348 Enhanced labeling of retinal protein during regeneration of optic nerve Water structure in goldfish, 828 Equation of state describing hydrophobic interactions, 2955 Tubulin aggregation and d',:^-.,::?ti?'?- Mediation by two distinct Wave equation vinblastine-binding site,, ,;. Maximal functions: Spherical means, 2174 Virazole Weierstrass integral Conformational properties of ribavirin, 4257 Conjugate points on a limiting extremal, 1800 Virial coefficient Weil-Petersson metric van der Waals-type equation of state for fluids with associating Completeness of Bergman metric and its subordinate metric, 4294 molecules, 1773 Wheat Viroid see Triticum aestivum L. Viroids are single-stri-d rd -c.ru1-.!'^' closed circular RNA molecules Wheat germ agglutinin existing as highly ' i-. !,.:uir-,.\.. s: i: structures, 3852 see also Agglutinin Virus Virus and lectin agglutination of erythrocytes: Spin label study of see also Bacteriophage; Provirus; Viroid; specific viruses membrane lipid-protein interactions, 3497 Virus assembly Wolff rearrangement Protein cleavage during virus assembly: Specificity of assembly 2-Diazo-3,3,3-trifluoropropionyl chloride: Reagent for photoaffinity dependent cleavage in bacteriophage T4, 4205 labeling, 1406 Virus infection Woolly monkey Cells that express viral antigens but lack H-2 determinants are not lysed Antigens and antibodies crossreactive with type C viruses of woolly by immune thymus-derived lymphocytes but are lysed by other monkey and gibbon ape in animal models and in humans, 1725 antiviral immune attack mechanisms, 3666 Virus-like particle Inheritance of killer phenotypes and double-stranded RNA in Ustilago Xanthine, 1-methyl-3-isobutyl maydis, 594 Conversion of 3T3 fibroblasts into adipose cells: Triggering of Virus production differentiation by prostaglamndinF2,, and 1-methyl-3-isobutyl xanthine, Differential effect of phosphonoacetic acid on expression of 4516 Epstein-Barr viral antigens and virus production, 1745 Induction and decay of :l:c.i::-'n i:d,lnicedamino acid transport in Virus, recombinant primary cultures of a:ci.'';;i , -(,?!-.I Paradoxical effects of Envelope-specific and sarcoma-specific nucleotide sequences from cycloheximide and puromycin, 4511 different parents in RNAs of avian tumor virus recombinants, 1073 Xanthosine 5'-monophosphate aminase Mapping oligonucleotides of Rous sarcoma virus RNA that segregate Specialized transduction of colicin El DNA in Escherichia coli K-12 by with polymerase and group-specific antigen markers in recombinants, phage lambda, 3238 '3952 Xenon Virus replication Allende meteorite: Isotopically anomalous xenon is accompanied by Replication of imnoplI;ism,lvinii: MVL51: Attachment of MVL51 parental normal osmium, 4253 DNA to host cell membrane, 1489 Xenon fluoride Virus structure Anigles between orthogonal spd bond orbitals with maximum strength, Asymmetric orientation of phage M13 coat protein in Escherichia coli 1403 cytoplasmic membranes and in synthetic lipid vesicles, 1159 Xenopus laevis Viscoelasticity Development of action potential mechanism of amphibian neurons Sof't polymers: Time-dependent response in moderately large isolated in culture, 1641 deformations, 981 DNA-relaxing activity and endonuclease activity in Xenopus laevis Viscosity oocytes, 4551 Viscosity of dilute gases and vapors, 4302 Xenopus laevis oocyte extract affects supercoiled simian virus 40 DNA: Viscosity of liquid metal, 988 Formation of complex DNA, 554 Visual cortex Xeroderma pigmentosum Cytoarchitectonic mapping by microdensitometry, 2928 Altered apurinic DNA endonuclease activity in group A and group D Visual excitation xeroderma pigmentosum fibroblasts, 1169 Rapid-flow resonance Raman spectroscopy of photolabile molecules: DNA single-strand breaks during repair of UV damage in human Rhodopsin and isorhodopsin, 1 fibroblasts and abnormalities of repair in xeroderma pigmentosum, 39 Retinal has highly dipolar vertically excited singlet state: Implications X-linked inheritance for vision, 2169 Menkes disease: Biochemical abnormality in cultured human fibroblasts, Visual pigment 604 Assignment of locus required for flavoprotein-linked monooxygenase X-ray expression to human chromosome 2, 4266 see also Irradiation, x- Visual system X-ray absorption spectroscopy Metabolic mapping of primary visual system of monkey by Structure-function relations in hemoglobin as determined by x-ray autoradiographic [l4C]deoxyglucose technique, 4230 absorption spectroscopy, 491 Vitamin A X-ray absorption edges in iron compounds and proteins, 1384 see Retinal; Retinoic acid; Retinol; Retinyl acetate X-ray crystallography Vitamin B-12 Crystal structure of complex between lumiflavin and see Cyanocobalamin 2,6-diamino-9-ethylpurine: Flavin adenine dinucleotide model Vitamin C exhibiting charge-transfer interactions, 3807 see Ascorbate Structure of L-arabinose-binding protein from Escherichia coli at 5 A Vitamin D resolution and preliminary results at 3.5 A, 2186 see 25-Hydroxycholecalciferol Three-dimensional structure of erabutoxin b neurotoxic protein: Vitamin D hydroxylase Inhibitor of acetylcholine receptor, 2991 see 25-Hydroxycholecalciferol 1-monooxygenase X-ray diffraction Vitamin K Applications of synchrotron radiation to protein crystallography, 128 see Phylloquinone Downloaded by guest on October 5, 2021 Proc. Natl. Acad. Sci. USA 73 (1976) Subject Index 4779

Conformation of uncomplexed [Phe4,Val6]antamanide crystallized from Zinc enzyme nonpolar solvents, 1782 Chemicalreactivities of catalyticand noncatalyticzinc or cobalt atoms of Crystalline semisynthetic ribonuclease-S', 1844 horse liver alcoholdehydrogenase: Differentiation by thermodynamic Double-stranded polynucleotides: Possible conformation, 2959 and kinetic properties,344 Structure of iron complex in methemerythrin, 349 Zone electrophoresis X-ray diffraction of actively shortening muscle, 813 Gram-preparativeprotein fractionation by isotachophoresis:Human X-ray photoabsorption growthhormone isohormones isolated, 732 Extended x-ray-absorption fine structure-Auger process for surface Zoology structure analysis: Proposed experiment, 2550 Anestheticstimulation of insect waterreceptors, 3315 Birds on islands in the sky: Originof montaneavifauna of Northern Melanesia,1765 Caecilianear, 3744 Yeast Chemo-anemotaxis:Behavioral response to sex pheromonein nonflying see Saccharomyces cerevisiae insects, 2524 Ethologicalisolation and matingexperience in Drosophilapaulistorum, 975 Groupselection amonglaboratory populations of Triboliumcastaneum, Zea mays 4604 Endonuclease recognition sites mapped on Zea mays chloroplast DNA, Photoprotectionby carotenoidpigments in copepodDiaptomus 4309 nevadensis,971 Zein RNase sensitivity of anteriormorphogenetic determinant in insect egg Zein synthesis in maize endosperm by polyribosomes attached to protein (Smittia sp., Chironomidae,Diptera), 3739 bodies, 515 Zooplankton Zinc Photoprotectionby carotenoidpigments in copepodDiaptomus Amino-acid sequence of equine renal metallothionein-lB, 3413 nevadensis,971 Electron microscopic x-ray microanalysis of normal and leukemic human Zygote,defective lymphocytes, 3690 Saccharomycescerevisiae mutant defective for nuclearfusion, 3651 Zn2+ as inhibitor and activator of fructose 1,6-bisphosphatase of rat Zymogen liver, 2692 Role of proteolyticenzymes in biologicalregulation (A Review),3825 Downloaded by guest on October 5, 2021