Journal of Clinical Medicine Review Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases María Magallón 1,2, Ana Esther Carrión 1,2, Lucía Bañuls 1,2, Daniel Pellicer 1,2 , Silvia Castillo 2,3 , Sergio Bondía 2, María Mercedes Navarro-García 2 , Cruz González 2,4 and Francisco Dasí 1,2,* 1 Research Group on Rare Respiratory Diseases (ERR), Department of Physiology, School of Medicine, University of Valencia, Avda. Blasco Ibáñez, 15, 46010 Valencia, Spain;
[email protected] (M.M.);
[email protected] (A.E.C.);
[email protected] (L.B.);
[email protected] (D.P.) 2 Research Group on Rare Respiratory Diseases (ERR), Instituto de Investigación Sanitaria INCLIVA, Fundación Investigación Hospital Clínico Valencia, Avda. Menéndez y Pelayo, 4, 46010 Valencia, Spain;
[email protected] (S.C.);
[email protected] (S.B.);
[email protected] (M.M.N.-G.);
[email protected] (C.G.) 3 Paediatrics Unit, Hospital Clínico Universitario de Valencia, Avda. Blasco Ibáñez, 17, 46010 Valencia, Spain 4 Pneumology Unit, Hospital Clínico Universitario de Valencia, Avda. Blasco Ibáñez, 17, 46010 Valencia, Spain * Correspondence:
[email protected]; Tel.: +34-67-651-5598 Abstract: Several studies have shown that some rare respiratory diseases, such as alpha-1 antitrypsin deficiency (AATD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and primary ciliary dysk- inesia (PCD) present oxidative stress (OS) and endoplasmic reticulum (ER) stress. Their involvement in these pathologies and the use of antioxidants as therapeutic agents to minimize the effects of OS are discussed in this review. Citation: Magallón, M.; Carrión, Keywords: oxidative stress; endoplasmic reticulum stress; antioxidant therapies; rare respiratory A.E.; Bañuls, L.; Pellicer, D.; Castillo, diseases; Alpha-1 antitrypsin deficiency; idiopathic pulmonary fibrosis; cystic fibrosis; primary S.; Bondía, S.; Navarro-García, M.M.; ciliary dyskinesia González, C.; Dasí, F.