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Tailored Optical Materials Newsletter Tailored Optical Materials David Böhnisch Dezember 2017 Thomas Jüstel Volume 11 Issue 12 Research & Latest Novel Development Publications Patents Boosting Antibiotic Potency with Light Conception: Prof. Dr. rer. nat.Thomas Jüstel Edited by: David Böhnisch Contact: [email protected] Research & Development ....................................................................................................................... 3 Boosting Antibiotic Potency with Light ........................................................................................... 3 Eviyos LED Prototype Revolutionizes Smart Headlights ................................................................ 5 Hailux Lighting unveils tunableGROW horticultural grow light .................................................... 6 LED business news: Seoul Semi, Cree, and Philips Lighting financial results ............................... 7 Osram will weave IoT lighting into clothing ................................................................................... 9 Velodyne LiDAR Launches the World’s Highest Resolution LiDAR for Autonomous Vehicles 11 Latest Publications ................................................................................................................................ 13 Particulate photocatalysts for overall water splitting ..................................................................... 13 Na3Tb(PO4)2: Synthesis, crystal structure and greenish emitting properties ................................. 13 3+ Structural and Optical Properties of Yellow-Emitting CaGd2ZrSc(AlO4)3:Ce Phosphor for Solid-State Lighting ....................................................................................................................... 13 3+ K7Ca9[Si2O7]4F:Ce : a novel blue-emitting phosphor with good thermal stability for ultraviolet- excited light emitting diodes .......................................................................................................... 14 3+ A broad-band orange-yellow-emitting Lu2Mg2Al2Si2O12:Ce phosphor for application in warm white light-emitting diodes ............................................................................................................. 14 Novel Patents ......................................................................................................................................... 15 Solid state lighting devices utilizing memristors ........................................................................... 15 A quantum dot and yag phosphor mixed doped for liquid crystal display device ......................... 15 Wavelength conversion members including phosphors having different thermal conductivities and volumes and projectors containing such converters ................................................................ 16 Lighting device including a phosphor light emitter and light projector, a vehicle headlamp using the same .......................................................................................................................................... 16 Film thickness measuring device ................................................................................................... 17 Volume 11 Issue 11 November 2017 Research & Development Boosting Antibiotic Potency with Light Multidrug-resistant (MDR) bacterial antioxidant defense; such oxidative stress is infections are a growing cause of concern toxic and causes damage to the bacterium’s worldwide. The World Health Organization DNA. highlighted the severity of this problem by designating drug-resistant strains of The method of Chatterjee and her colleagues Escherichia coli and Klebsiella pneumoniae exploits ROS toxicity by using engineered “priority 1 critical class bacterial pathogens in QDs to produce, on-demand, an urgent need of effective antibiotics.” overwhelming amount of intracellular superoxide (a particularly harmful ROS). That Now, a team of researchers from the superoxide flood, they say, weakens MDR University of Colorado Boulder, USA, reports bacteria and makes the bugs more susceptible that it has developed a platform based on to existing antibiotics. intracellular light-activated quantum dots (QDs) that could help address the problem. In The group’s “tailored redox potential” QDs the method, the QDs work inside living cells are made of cadmium telluride and are small to generate a superoxide that acts as a kind of enough (less than 3 nm in diameter) to easily sucker punch, weakening the bacteria and enter bacteria through holes in the cell wall. making the superbugs more vulnerable to The QDs can be turned on and off with a existing antibiotics (Sci. Adv., doi: specific wavelength of light, and their 10.1126/sciadv.1701776). oxidation potential is tuned for superoxide radicals from molecular oxygen. According to the Boulder team, its QD platform reduced antibiotic resistance by a Delivering the punch factor of 1,000 in in vitro multidrug-resistant (MDR) isolate infections. In animal model During in vitro tests with clinical MDR demonstrations with Caenorhabditis elegans isolates in E. coli, K. pneumoniae and (a microscopic worm), the combination of Salmonella enterica, the researchers found superoxide-generating QDs with the antibiotic that combining their superoxide-producing ciprofloxacin reduced the bacterial load in the QDs with antibiotics produced a synergistic worm’s gut more than treatment with the interaction in more than 75 percent of the antibiotic alone. Team lead Anushree tests. Within those synergistic combinations, Chatterjee says that the QD platform could they observed a reduction in the effective someday offer clinicians “an adaptable, antibiotic resistance of the clinical isolate multifaceted approach to fighting infections infections by a factor of 1,000. During animal that are already straining the limits of current model demonstrations with C. elegans, the treatments.” researchers found that a worm’s chance of surviving an MDR bacterial infection Overwhelming bacterial defenses increased when it was treated with a combination of superoxide-generating QDs Reactive oxygen species (ROS) are present in and ciprofloxacin compared to only low levels during normal bacterial aerobic ciprofloxacin. respiration. Bacteria control ROS levels by producing antioxidants. However, elevated The team says the results from its tests on ROS levels can overwhelm a bacterium’s clinical MDR isolates and demonstrations 3 Volume 11 Issue 11 November 2017 with C. elegans “highlight the ability to big advantage over conventional small- engineer superoxide generation to potentiate molecule-based antibiotics. The team sees its antibiotic activity and combat highly drug- QDs eventually being used as a technology resistant bacterial pathogens.” platform for treating a wide variety of infections and for other therapeutic The researchers say that their QD technology, applications. unlike previous antibiotic treatments, can work intracellularly with a high level of Source: specificity. Chatterjee adds that the QDs are https://www.osa- inexpensive, don’t require developing new opn.org/home/newsroom/2017/october/boosti antibiotics, and are very easily scaled up—a ng_antibiotic_potency_with_light/ 4 Volume 11 Issue 11 November 2017 Eviyos LED Prototype Revolutionizes Smart Headlights The Eviyos prototype developed by Osram of 3 lm at 11 mA. Initial prototypes have Opto Semiconductors is the world’s first already exhibited more than 4.6 lm per pixel. hybrid LED and represents major progress Customers can vary the number of hybrid toward the first market-ready smart LEDs in their applications and supplement controllable high-resolution LED. As soon as them with conventional LEDs, depending on oncoming traffic is detected the appropriate the particular requirements that need to be pixels are automatically switched off so met. drivers of oncoming vehicles are not dazzled. The prototype, integrated in a demonstrator “The hybrid LED is another example of our from Osram Specialty Lighting, were on show products making a major contribution to for the first time at ISAL from September 25 improving the quality of life in many different through 27, 2017 in Darmstadt. areas. With Eviyos we are helping to make the roads safer and improve comfort and convenience for drivers. We are proud that we can present the first prototype so soon after completing the research project. We are now another stage further toward series production”, said Thomas Christl, Marketing Manager at Osram Opto Semiconductors. Eviyos is not only compact and powerful but also energy-efficient thanks to the precise control and dimmability of the individual pixels. The only pixels that are ever on are the Eviyos illuminates surroundings in high-beam ones that are actually needed at the time. quality, ensures other road users and drivers are not dazzled. The prototype is the first integrated -structured LED-chip with 1,000+ At its planned launch at the start of 2020 pixel. Eviyos will form a separate product family hybrid LED of a μ offering a wide range of possible applications. Eviyos has its basis in the μAFS research Smart headlights are just one of the potential project which was completed in the fall of areas in which intelligent selective pixel 2016. The project involved various partners control can be applied. from the industrial sector and was coordinated by Osram Opto Semiconductors. The Source: prototype combines two technologies in one https://www.led- component: a light emitting chip and professional.com/technology/light-
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