DOCSLIB.ORG

Photo-Enhanced Modification of Human Skin Elastin in Actinic Elastosis by NE-(Carboxymethyl)Lysine, One of the Glycoxidation Products of the Maillard Reaction

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Photo-Enhanced Modification of Human Skin Elastin in Actinic Elastosis by NE-(Carboxymethyl)Lysine, One of the Glycoxidation Products of the Maillard Reaction Photo-Enhanced Modification of Human Skin Elastin in Actinic Elastosis by NE-(Carboxymethyl)lysine, One of the Glycoxidation Products of the Maillard Reaction Kurniko M.izutari, ';' Tomomichi 011.0, * Kazuyoshi Ikeda, t Ken-ichi Kayashima, * and Seikoh Horiuchit ' Department of Dermatology, Kumamoto University School of Medicin c, and i"Departmcnt of Biochcmistry. Kumamoto Uni\'crsity School of Medici ne, HOllj O, Kumamoto. Japan Long- term incubation of proteins with glucose leads were modified by CML. Further immunohistochemi­ to the formation of advanced glycation end products cal and immunoelectron microscopic examination (AGEs), which are characterized by fluorescence, with 6D12 demonstrated CML accumulates pre­ brown color, and cross-linking. Formation of AGEs ill dominantly in elastic fibers especially in the amor­ vitro requires oxygen and is dependent on transition phous electron-dense materials corresponding to metal- catalyzed oxidation of glucose or Amadori photo-induced degenerated area rather than the products. AGEs are thought to be involved in aging electron-lucent region. Imnlunochelnical analyses and age-enhanced diseases such as diabetic compli­ with enzyme-linked il11munosorbent assay (ELISA) of cations, atherosclerosis, dialysis- related amyloidosis, elastase-soluble fractions delnonstrated that the CML and Alzheimer's disease. Chronic exposure of the levels of the sun-exposed area were significantly skin to sunlight induces hyperplasia of the elastic higher than those of the sun-unexposed area. We tissue in the upper dermis known as actinic elastosis. conclude that ultraviolet-induced oxidation l11ay ac­ Herein we used a monoclonal anti- AGE antibody celerate CML formation in actinic elastosis of photo­ (6D12) whose epitope is NE-(carboxymethyl)lysine aged skin. Key 1UD/'ds: plrotoagillgladval/.ced giycatioll e/ld (CML) , one of the glycoxidation products of AGEs, p,'odllctS. ] I,west Del'l/Iatoi 108:797-802, 1997 and demonstrated that the lesions of actinic elastosis ong-term incubation of proteins with glucose ill III'lro Several AGE Structures have been identified including pyrraline leads, through early-stage products such as a Schiff base (Hayase et ai, 1989), pentosidine (Sell el al 1989), NE-(carboxy_ and Amadori rearr~ngem e nt products, to the formation m ethyl)lysine (CML) (Ahmed et ai, 1986). and crosslines (Naka­ of advanced glycatlon end products (AGEs), wluch are mura et ai, 1992). It is still not known, however, whetber one of characterized by fluorescence, brown color, and cross­ these compounds contributes, as a major AGE structure. to the Llinking (Maillard, 1912). We prepared an anti-AGE monoclonal pathogenesis of these diseases or whetber otber structure(s) may antibody (6D12) in mice (Horiuchi et ai, 1991). Immunologic be involved in this process. Although the presence of AGEs in studies using 6D12 not only demonstrated the presence of AGEs in several human tissues was successfully demonstrated by our several human tissues but also suggested a potential link of AGEs to anti-AGE monoclonal antibody (6D12) as described above. no aging (Araki et ai, 1992; Kimura el ai, 1995, 1996) and age­ info rmatio n was available until quite recently about its AGE enhanced diseases such as diabetic complica tions (Yamada cl ai, structure. Our recent study revealed that 6D12 is able to 1994; Makino 1995), atherosclerosis (Kume 1995; et ai, ct ai, recognize a CML-protein adduct as an epitope (Ikeda et ai, Horiu chi, 1996; Meng et ai, 1996), and dialysis-related amyloidosis 1996), stro ngly suggesting an ill lIillO importan ce of CML among (Miyata et 1993, 1996). Immunologic studies using anti-AGE ai, AGE structures. polyclonal antibodies were also performed in other laboratories, In the skin after chronic exposure to sunlight, especially in demonstrating the presence of AGEs in h uman plasma (Makita et nl, persons with a fair complexion, hyperplasia of the ela sti c tissue is 1992a; Bucala et ai, 1993), hemoglobin (Makita et ai, 1992b), usually evident in the upper dermis by the age of30. These changes atherosclerotic coronal'Y artery (Nakamura ef ai, 1993), and lesions found in the photoaged skin are ca ll ed actinic elastosis (Kligman. of Alzheimer's disease (Smith ct ai, 1994; Vitek el al . 1994) . 1969). Accumulated elastotic materials are thought to be derived from elastic fibers because of their reacti vity WitIl the anti-elastin I, 8, Manuscript received October 1996; revised Jan uar)' 1997; accepted antibody and sellSitivi ry to elastase digestion (Pieraggi, 1988). for publication Jalluary 13. 1997. Although it has no t been clear how chronic solar exposure can Reprint requests to: Dr. TOlllomichi OliO, Departlllent of Dermatology. Kumamoto University School of Medicine, Honj o, 1-1-1 . Kumamoto 860. induce accumulation of elastic fibers, deleterious efFects of sunlight japaJl. could often be attributed to oxidation by fi'ee radical intermediates Abbreviations: AGE(s). advanced glycation clld prodllct(s); CML, N <­ (Sugiyama et ai, 1984; Buettner el al. 1987; Miyachi, 1993; Pent­ (carboxymethyl)l ysi ne . land, 1994). It is therefore possible that ultravio let-induced o xida- 0022-202X/ 97 IS1 0.50 • Copyright © 1997 by The Society for In vestiga ti ve Dermarology, Inc. 797 798 MIZUTARI ET AL THE JOURNAL OF INVESTIGATIVE DERMATOLOGY tive stress may have some role in the pathogenesis of actinic One of thesc scctions was used to observe under a confocal laser scanning elastosis through the formation of oxidation products. microscope (MRC~1024; BioRad. Heme! Hempstead, U.K.). A yellow CML is formed ill IJilrO by oxidative cleavage of Amadori addu cts fluorescence occurs when botlt green alld !"ed staills bind to the same location. Nonirnl11unc rabbit alld mOllse serum (Cappel. West Chester, PAl (Ahmed et al. 1986; Dunn et ai, 1991) OJ" Scbitr bases (Glomb and were used as negative control. No il11l1lulJoreactiOll was observed in Monnier, 1995) or by modification with glyoxal gen erated directly formalin-fixed and paraffin-embedded specimens. through autoxidation of g lucose (Wells-Knecht ct ai, 1995) and h as been proposed as a potential biomarker of oxidative damage of Immunoelectron Microscopy T he specimens fi'oll1 the face of patien ~ tissu e proteins ill Pi/)O (Baynes, 199t; Fu et ai, 1994). CML is 48, 49, and 51 were s ul~jccted to il11l11unoelectron microscopic study by a therefore termed a "glycoxidation product" among AGE structures. post-embedding method Ll sing anti-elastin antibody and 6D12. The tis ue There is currently no evidence that AGEs result from UV-induced sa mples were fixed with Karnovsky fixati ve lor 24 h at 4°C, washed with PBS. dehydrated ill a graded scries of ethanol, and embedded in LR White oxidation. To test this hypothesis, we h ave attempted to determine resin (London Resin, Berkshire, U.K.). Ultrathin sections were floated ou whether CML modification could occur in the lesions of actinic drops of buffer A (0.5% BSA. 0.1·y" gelatin, and 20 111M NaN., in PBS) for elastosis. Immuno logic studies using 6D12, a monoclonal antibody 15 min and incubated for 1 h at room temperature with either the specific for CML structure, demonstrated CML accumulation anti-ela sci1l antibody (1 :500 dilution) or 6012 (5 !Lg per ml). The sections predominantly in elastic Etbers especially in the amorphous elec­ were washed with bllffer and further incubated for 3(l min with 15-.I1Ill tron-dense material corresponding to photo-induced degenerated colloidal gold-conjugated goat anti-mouse IgG antibody (Aurioll, area. T h ese results indicate tbat ultraviolet-induced oxidation may Wageningen, Netherlands) ill bulrer A. These sections were washed with accelerate CML formation in actinic elastosis of t he photoaged skin. buffer A, PBS, and distilled water, stained with lIranyl acetate, and observed tinder a Hitachi H300 electron microscope. For double labeling with MATERIALS AND METHODS different size of gold particles. 6- and 15-nm coll oidal gold-conjugated goat Tissue Preparation Fifry-seven specimens were obtained fi'om S'I Japanese anti-mouse IgG antibodies wel'c uscd to locali ze the bound anti-elastin patients undergoing del111atologi c surgery for the treatment of benign and antibody and 6D12, respectively. matignallt epith eli al tllmors at Kumamoto University School of Medicine Biochenlical Analysis We studied skin tissues obtain ed fj'om skin Hospital (Table 1). Specimens were obtai ned ti'om various sires including lace surgery of sun-exposed and sun-unexposed area in 18 individuals. Elastin (cheek, forehead, and nose), neck, back of the hand, fo rearm, shoulder, chest, was solubilized with clastose (Fleischl11,~jer mId Lara. 1966), a1ld its immu­ abdomen, back, groin , and sale of botb male and female patients. Their "ges noreactivity to 6D 12 wa s derermined by noncompetitive enzyme-linked ranged frOI11 9 to 100 y. The peripheral tissues sllrrounding the tumor were il11l'l1unosorbcnt assay (ELISA) using the fo ll owing procedure (Horiu chi II procUl'cd at the time of surgery. Prior informed conse nt. WllS obtained in all (/1 . 1991). Ea ch skin specimen was rapidly fj'ozen and sli ced in to 10-I.t.rn cases. W hen the subjects were juveniles, informed consent was obtained fi'ol11 sections. Skin sections wcrc washed t.hree times with PBS and incubated their parents. Specimens utilized in the srudy were all hi stologica ll y tumor-free overnight with elastase (W,lko Chemica l, Osaka. JapHlI) in 0.1 M Tris(hr­ and contained epidemlis and underl ying dennis. Tire samples were sectioned droxymethyl)arninomethane hydrochloride bulter (pH 8.8) at 3 rc. The and processed in two ways: one W,IS fOt11ralitl-f,xed and paraffin-embedded and elastase-soluble fraction was collected as "peptide fraction. " Protein COll­ the other WaS rapidly frozen lind stored at - BO °C. Paraffll1-embedded samples centrations were dcrcrnlincd by bicincboninic acid protein assay reClgent ill 6-I.UTI sections were staiJ1Cd with henlatoxylin and eosi.n for diagnosis and the (Pierce.
Load more

Recommended publications
  • Glossary for Narrative Writing
    Periodontal Assessment and Treatment Planning Gingival description Color: o pink o erythematous o cyanotic o racial pigmentation o metallic pigmentation o uniformity Contour: o recession o clefts o enlarged papillae o cratered papillae o blunted papillae o highly rolled o bulbous o knife-edged o scalloped o stippled Consistency: o firm o edematous o hyperplastic o fibrotic Band of gingiva: o amount o quality o location o treatability Bleeding tendency: o sulcus base, lining o gingival margins Suppuration Sinus tract formation Pocket depths Pseudopockets Frena Pain Other pathology Dental Description Defective restorations: o overhangs o open contacts o poor contours Fractured cusps 1 ww.links2success.biz [email protected] 914-303-6464 Caries Deposits: o Type . plaque . calculus . stain . matera alba o Location . supragingival . subgingival o Severity . mild . moderate . severe Wear facets Percussion sensitivity Tooth vitality Attrition, erosion, abrasion Occlusal plane level Occlusion findings Furcations Mobility Fremitus Radiographic findings Film dates Crown:root ratio Amount of bone loss o horizontal; vertical o localized; generalized Root length and shape Overhangs Bulbous crowns Fenestrations Dehiscences Tooth resorption Retained root tips Impacted teeth Root proximities Tilted teeth Radiolucencies/opacities Etiologic factors Local: o plaque o calculus o overhangs 2 ww.links2success.biz [email protected] 914-303-6464 o orthodontic apparatus o open margins o open contacts o improper
    [Show full text]
  • Actinic Keratoses Final Report
    Actinic Keratoses Final Report Mark Helfand, MD, MPH Annalisa K. Gorman, MD Susan Mahon, MPH Benjamin K.S. Chan, MS Neil Swanson, MD Submitted to the Agency for Healthcare Research and Quality under contract 290-97-0018, task order no. 6 Oregon Health & Science University Evidence-based Practice Center 3181 SW Sam Jackson Park Road Portland, Oregon 97201 May 19, 2001 Actinic Keratoses Structured Abstract Objective: To examine evidence about the natural history and management of actinic keratoses (AKs). Search Strategy: We searched the MEDLINE database from January 1966 to January 2001, the Cochrane Controlled Trials Registry, and a bibliographic database of articles about skin cancer. We identified additional articles from reference lists and experts. Selection Criteria: We selected 45 articles that contained original data relevant to treatment of actinic keratoses, progression of AKs to squamous cell cancer (SCC ), means of identifying a high-risk group, or surveillance of patients with AKs to detect and treat SCCs early in their course. Data Collection and Analysis: We abstracted information from these studies to construct evidence tables. We also developed a simple mathematical model to examine whether estimates of the rate of progression of AK to SCC were consistent among studies. Finally, we analyzed data from the Medicare Statistical System to estimate the frequency of procedures attributable to AK among elderly beneficiaries. Main Results: The yearly rate of progression of an AK in an average-risk person in Australia is between 8 and 24 per 10,000. High-risk individuals with multiple AKs have progression rates as high as 12-30 percent over 3 years.
    [Show full text]
  • Advanced Technology with Maximum Versatility for Dermatology & Aesthetic Procedures
    ADVANCED TECHNOLOGY WITH MAXIMUM VERSATILITY FOR DERMATOLOGY & AESTHETIC PROCEDURES Fractional and Non-Fractional Applications Skin Resurfacing Skin Rejuvenation Skin Tightening Scar Remodeling Skin Tags & Benign Skin Lesion Skin Imperfections “The Pixel CO2 is brilliant; it is a must - have device for all dermatologists and plastic surgeons.” Dr. Michael Shochat, MD, Dermatologist. 2 | ALMA Pixel CO2 ALMA The carbon dioxide (CO2) laser has been known to provide some of the most dramatic, age-defying results in the treatment of challenging skin imperfections including wrinkles, fine lines, photodamage, uneven skin tone and skin laxity, as well as in scar treatment, skin tags and benign tumors. Using the power of the CO2 laser, the optimal mix of ablative and thermal effects and an array of applicators and treatment modes for highly tailored procedures, Alma’s Pixel CO2 brings unparalleled precision and innovation to the field of dermatology and plastic surgery. Alma Pixel CO2 is a highly flexible system for char-free tissue ablation, vaporization, excision, incision and coagulation of soft tissue. It allows physicians full control of treatment parameters, including level and depth of ablation and thermal control via pulse duration and mode of energy delivery. This versatility maximizes precision and treatment results while minimizing unnecessary tissue damage. The CO2 laser uses a 10,600nm wavelength, which is ideal for collagen matrix renewal and an optimal choice for treating an extensive range of dermatological issues. The CO2 laser has the ability to perform efficient, highly precise fractional and non-fractional laser treatments using the widest assortment of advanced applicators. With powerful performance and hundreds of treatment options, Alma Pixel CO2 opens the door to new possibilities in dermatological and surgical treatments.
    [Show full text]
  • Copyrighted Material
    Trim size: Trim Size: 216mm x 279mm Holm bindex.tex V3 - 05/25/2015 11:50 A.M. Page 361 Index figures are in italics; tables/boxes are in bold aging and periodontal disease anticoagulant therapy epidemiology, 212–213 ADP anticoagulant platelet inhibitor, A periodontal inflammation, systemic 257–258 acetaminophen (paracetamol), 92, 95, 99, 270, diseases and aging, 218 cyclooxygenase inhibitors, 257 275 risk indicators/population, 213–215 warfarin, 257 acidulated phosphate fluoride (AFP), 195 susceptibility, 215–218 antihistamines, 256 actinic cheilitis (solar cheilitis), 72 alcohol aphasia, 345 Actinic elastosis of lower lip, 235 dementia, 112 Appletree dental truck, 330 Actinomyces gerencseriae, 186 mouth cancer, 158 apraxia, 345 Actinomyces Israelii, 186 oral cancer, 136, 236 Arthritis and oral hygiene/denture insertion,72 Active coronal/root caries in mandibular sugars, 138 ‘artificial salivas’, 251 anterior teeth,74 tooth wear, 139 Assessment tools for oral examination,76 activities of daily living (ADL), 64, 70, 121–122, alendronate see bisphosphonate asthma 315 allergy dental management, 97–98 acupuncture (salivary stimulation), 251 dental management, 82–83 overview, 97 adaptation overview, 82 Atrophic mandibular posterior ridge,75 aging, 56 aloe vera, 251 attrition (occlusal wear), 73–74 response, 13 Alveolar bone loss prevention, 160 Attrition (occlusal wear), 74 theories, 7 alveolar ridge, 75, 142 atypical presentation of disease, 62 Addison’s disease, 72, 94 Alzheimer’s disease (AD) auditory function ADP antagonist platelet inhibitor,
    [Show full text]
  • UV Radiation Exposure in Welders: Impact on the Skin and Eyes
    CASE REPORT UV Radiation Exposure in Welders: Impact on the Skin and Eyes D. Michael Piernick II, MD; Marla N. Jahnke, MD; Alice C. Watson, MD protection. We report 3 welders with skin disease attrib- PRACTICE POINTS uted to occupational exposure to UVR. • Arc welding can be a major source of UV radiation exposure. Case Reports • Welders should be advised to work with proper Patient 1—A 41-year-oldcopy man presented for evalua- ventilation and with welding masks, clothing, tion of treatment-resistant cutaneous lupus. During the and gloves that not only are fire retardant but 10-year disease course, the patient was treated by both also are UV resistant. dermatologists and rheumatologists with frequent exac- erbations and poor disease control. At the time of presen- tation,not treatment with hydroxychloroquine 200 mg twice daily, azathioprine 50 mg twice daily, intramuscular Arc welding is an occupation with exposure to intense bursts of methylprednisolone acetate injectable suspension 40 mg, UV radiation (UVR). Although industrial settings may be aware of and prednisone 20 mg daily was failing. Physical exami- UV light exposure during welding, physicians may be unaware ofDo this source. We report 3 welders with skin diseases that may have been nation revealed polycyclic erythematous plaques typi- caused or exacerbated by occupational UV light exposure: refractory cal of subacute cutaneous lupus erythematosus. A skin subacute cutaneous lupus erythematosus, diffuse actinic damage biopsy confirmed the diagnosis. Upon further discus- spared by the area protected by safety goggles, and squamous sion of exacerbating risk factors, the patient noted UVR cell carcinoma developed outside of the area protected by a face exposure while working as a welder.
    [Show full text]
  • Dermatopathology of the Degenerative, Metabolic, and Storage Diseases
    DERMATOPATHOLOGY OF THE DEGENERATIVE, METABOLIC AND STORAGE DISEASES (Nobody wants this lecture) Daniel J. Santa Cruz St Louis, MO, USA Thanks to: Dr Franco Rongioletti, Naples, Italy Dr Mario Marini, Buenos Aires, Argentina Dr Susan Mallory, St Louis, MO DERMATOPATHOLOGY OF THE ELASTIC FIBERS Daniel J. Santa Cruz Cutaneous Pathology St Louis, MO, USA ELASTIC FIBERS Oxytalan Elaunin Elastic fibers Elastic tendons of the arrectore pilori ELASTIC TISSUE STAINS Verhoff-Van Giesson Orcein (Orcein-Giemsa) Aldehide fucsin (Gomori) Iron galein (Churukian) Fucsin resorcin (Weigert) AUTOFLUORESCENCE ELASTOTIC PROCESSES Actinic elastosis Coloid milium Elastotic papules of the ear Linear focal elastosis Acrokeratoelastoidosis Elastofibroma ELASTOSIS Morphea ELASTOTIC PAPULE OF THE EAR ACROKERATOELASTOIDOSIS ELASTOFIBROMA ELASTIC NEVUS Isolated Multiple Associated with osteopoikilosis (Buschke-Ollendorf syndrome) BUSCHKE-OLLENDORF SYNDROME University of Miami . Autosomal dominant . Osteopoikilosis . Dermatofibrosis lenticularis disseminata TRANSEPIDERMAL MIGRATION OF ELASTIC FIBERS . Discoid lupus erytemathosus . Keratoacanthoma . Scar KERATOACANTHOMA PSEUDOXANTHOMA ELASTICUM Primary Acquired Post treatment Perforative post pregnancy Fertilizer (Salt peter) PSEUDOXANTHOMA ELASTICUM PSEUDOXANTHOMA ELASTICUM PSEUDOXANTHOMA ELASTICUM ELASTIC DERMATOSES SUI GENERIS Elastosis perforans serpiginosa Elastolytic (actinic) granuloma ELASTOSIS PERFORANS SERPIGINOSA ELASTOSIS PERFORANS SERPIGINOSA ELASTOLYTIC PROCESSES Stria Cutis
    [Show full text]
  • Visualization and Treatment of Subclinical Actinic Keratoses with Topical Imiquimod 5% Cream: an Observational Study
    Hindawi Publishing Corporation BioMed Research International Volume 2014, Article ID 135916, 4 pages http://dx.doi.org/10.1155/2014/135916 Clinical Study Visualization and Treatment of Subclinical Actinic Keratoses with Topical Imiquimod 5% Cream: An Observational Study Daisy Kopera and Helmut Kerl Department of Dermatology, Medical University Graz, Auenbruggerplatz 89, 8036 Graz, Austria Correspondence should be addressed to Daisy Kopera; [email protected] Received 4 February 2014; Revised 19 March 2014; Accepted 31 March 2014; Published 11 May 2014 Academic Editor: Tadamichi Shimizu Copyright © 2014 D. Kopera and H. Kerl. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Imiquimod 5% is licensed for the treatment of external genital warts, superficial basal cell carcinoma, and actinic keratosis (AK) and is being used experimentally in various other dermato-oncological conditions. Objective. This observational study shall show that nonmelanoma skin cancer can be detected at its earliest subclinical stage by its reaction with imiquimod and can be cleared by finishing the course of treatment. Material and Methods. In this single arm trial 15 patients with chronically sun- exposed skin who had no clinical evidence of AK were treated with 5% imiquimod cream on the face or scalp for 4 weeks three times per week. Results. During treatment, all patients developed multiple areas with mild to moderate inflammatory skin reactions, such as erythema, induration, and scaling. Biopsies obtained from 12 patients prior to treatment revealed no malignancies. However, in cases with more pronounced inflammation during treatment, targeted biopsies indicated very early malignant alterations.
    [Show full text]
  • Views in Allergy and Immunology
    CLINICAL REVIEWS IN ALLERGY AND IMMUNOLOGY Dermatology for the Allergist Dennis Kim, MD, and Richard Lockey, MD specific laboratory tests and pathognomonic skin findings do Abstract: Allergists/immunologists see patients with a variety of not exist (Table 1). skin disorders. Some, such as atopic and allergic contact dermatitis, There are 3 forms of AD: acute, subacute, and chronic. are caused by abnormal immunologic reactions, whereas others, Acute AD is characterized by intensely pruritic, erythematous such as seborrheic dermatitis or rosacea, lack an immunologic basis. papules associated with excoriations, vesiculations, and se- This review summarizes a select group of dermatologic problems rous exudates. Subacute AD is associated with erythematous, commonly encountered by an allergist/immunologist. excoriated, scaling papules. Chronic AD is associated with Key Words: dermatology, dermatitis, allergy, allergic, allergist, thickened lichenified skin and fibrotic papules. There is skin, disease considerable overlap of these 3 forms, especially with chronic (WAO Journal 2010; 3:202–215) AD, which can manifest in all 3 ways in the same patient. The relationship between AD and causative allergens is difficult to establish. However, clinical studies suggest that extrinsic factors can impact the course of disease. Therefore, in some cases, it is helpful to perform skin testing on foods INTRODUCTION that are commonly associated with food allergy (wheat, milk, llergists/immunologists see patients with a variety of skin soy, egg, peanut, tree nuts, molluscan, and crustaceous shell- Adisorders. Some, such as atopic and allergic contact fish) and aeroallergens to rule out allergic triggers that can dermatitis, are caused by abnormal immunologic reactions, sometimes exacerbate this disease.
    [Show full text]
  • Skin Aging Handbook
    SKIN AGING HANDBOOK An Integrated Approach to Biochemistry and Product Development Edited by Nava Dayan Norwich, NY, USA Copyright © 2008 by William Andrew Inc. No part of this book may be reproduced or utilized in any form or by any means, electronic or me- chanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the Publisher. ISBN: 978-0-8155-1584-5 Library of Congress Cataloging-in-Publication Data Skin aging handbook : an integrated approach to biochemistry and product development / edited by Nava Dayan. p. ; cm. -- (Personal care and cosmetic technology) Includes bibliographical references and index. ISBN 978-0-8155-1584-5 (alk. paper) 1. Skin--Aging. 2. Cosmetics. 3. Dermatologic agents. 4. Cosmetic industry. 5. Dermatologic agents industry. I. Dayan, Nava. II. Series. [DNLM: 1. Skin Physiology--drug effects. 2. Aging--drug effects. 3. Chemistry, Pharmaceutical. 4. Cosmetics--economics. 5. Cosmetics--pharmacology. 6. Cosmetics--therapeutic use. WR 102 S62715 2008] QP88.5.S553 2008 612.7’9--dc22 2008009757 Printed in the United States of America This book is printed on acid-free paper. 10 9 8 7 6 5 4 3 2 1 Published by: William Andrew Inc. 13 Eaton Avenue Norwich, NY 13815 1-800-932-7045 www.williamandrew.com Cover Design by Russell Richardson ENVIRONMENTALLY FRIENDLY This book has been printed digitally because this process does not use any plates, ink, chemicals, or press solutions that are harmful to the environment. The paper used in this book has a 30% recycled content. NOTICE To the best of our knowledge the information in this publication is accurate; however the Publisher does not assume any responsibility or liability for the accuracy or completeness of, or consequences arising from, such information.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 7,359,748 B1 Drugge (45) Date of Patent: Apr
    USOO7359748B1 (12) United States Patent (10) Patent No.: US 7,359,748 B1 Drugge (45) Date of Patent: Apr. 15, 2008 (54) APPARATUS FOR TOTAL IMMERSION 6,339,216 B1* 1/2002 Wake ..................... 250,214. A PHOTOGRAPHY 6,397,091 B2 * 5/2002 Diab et al. .................. 600,323 6,556,858 B1 * 4/2003 Zeman ............. ... 600,473 (76) Inventor: Rhett Drugge, 50 Glenbrook Rd., Suite 6,597,941 B2. T/2003 Fontenot et al. ............ 600/473 1C, Stamford, NH (US) 06902-2914 7,092,014 B1 8/2006 Li et al. .................. 348.218.1 (*) Notice: Subject to any disclaimer, the term of this k cited. by examiner patent is extended or adjusted under 35 Primary Examiner Daniel Robinson U.S.C. 154(b) by 802 days. (74) Attorney, Agent, or Firm—McCarter & English, LLP (21) Appl. No.: 09/625,712 (57) ABSTRACT (22) Filed: Jul. 26, 2000 Total Immersion Photography (TIP) is disclosed, preferably for the use of screening for various medical and cosmetic (51) Int. Cl. conditions. TIP, in a preferred embodiment, comprises an A6 IB 6/00 (2006.01) enclosed structure that may be sized in accordance with an (52) U.S. Cl. ....................................... 600/476; 600/477 entire person, or individual body parts. Disposed therein are (58) Field of Classification Search ................ 600/476, a plurality of imaging means which may gather a variety of 600/162,407, 477, 478,479, 480; A61 B 6/00 information, e.g., chemical, light, temperature, etc. In a See application file for complete search history. preferred embodiment, a computer and plurality of USB (56) References Cited hubs are used to remotely operate and control digital cam eras.
    [Show full text]
  • Periorbital and Tragal Cutaneous Lesions
    PHOTO CHALLENGE Periorbital and Tragal Cutaneous Lesions Alexander Mounts, DO, MA; Kristopher M. Peters, DO A 91-year-old White man with no personal or family history of skin cancer presented to the der- matology clinic for a total-body skin examination. A 6×5-cm grouped cluster of open comedones in the periorbital region and on the left tragus as well as surrounding actinic damaged skin with coarse rhytides, dyschromia,copy and lentigines were seen. He had a history of excessive UV exposure and noted that the lesions had been present for approximately 10 years. They were asymptomatic andnot remained unchanged since their onset. WHAT’S YOUR DIAGNOSIS? a. actinic granuloma b. basal cell carcinoma Doc. chloracne d. erosive pustular dermatosis e. Favre-Racouchot syndrome PLEASE TURN TO PAGE E28 FOR THE DIAGNOSIS CUTIS Dr. Mounts is from the Naval Medical Center Pensacola, Florida. Dr. Peters is from Madigan Army Medical Center, Joint Base-Lewis McChord, Washington. The authors report no conflict of interest. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Navy, US Army, US Department of Defense, or the US government. Correspondence: Alexander Mounts, DO, MA ([email protected]). doi:10.12788/cutis.0278 WWW.MDEDGE.COM/DERMATOLOGY VOL. 107 NO. 5 I MAY 2021 E27 Copyright Cutis 2021. No part of this publication may be reproduced, stored, or transmitted without the prior written permission of the Publisher. PHOTO CHALLENGE DISCUSSION THE DIAGNOSIS: Favre-Racouchot Syndrome avre-Racouchot syndrome, also known as nodu- Treatment consists of typical comedonal therapies such as lar elastosis with cysts and comedones, is seen in tretinoin or comedone extraction.
    [Show full text]
  • UC Davis Dermatology Online Journal
    UC Davis Dermatology Online Journal Title Elastolytic giant cell granuloma: clinic-pathologic review of twenty cases Permalink https://escholarship.org/uc/item/80q2b8gb Journal Dermatology Online Journal, 19(10) Authors Gutierrez-Gonzalez, Enrique Gomez-Bernal, Silvia Alvarez-Perez, Adriana et al. Publication Date 2013 DOI 10.5070/D31910020019 License https://creativecommons.org/licenses/by-nc-nd/4.0/ 4.0 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Volume 19 Number 10 October 2013 Case Report Elastolytic giant cell granuloma: clinic-pathologic review of twenty cases Enrique Gutierrez-Gonzalez MD, Silvia Gomez-Bernal MD, Adriana Alvarez-Perez MD, Dolores Sanchez- Aguilar PhD, Jaime Toribio PhD Dermatology Online Journal 19 (10): 3 Department of Dermatology, Complejo Hospitalario Universitario. Faculty of Medicine. Santiago de Compostela, La Coruna, Spain Correspondence: Enrique Gutierrez-Gonzalez, MD Department of Dermatology, Complejo Hospitalario Universitario Faculty of Medicine, Santiago de Compostela ABSTRACT Background: O’Brien described four histopathological patterns of actinic granuloma (AG). Since then, only single cases and a few series have been reported in the literature, most corresponding to cases of the giant cell type. Methods: We reviewed all the cases diagnosed as AG or elastolytic giant cell granuloma (EGCG) in our department from 1988 until 2010. The biopsies were classified into the four patterns previously described. Results: Giant cell pattern was found to be the most frequent (70% of the cases). In four cases, the biopsies showed more than one histopathologic pattern. All the lesions were located on sun-exposed areas or were related to chronic heat exposure. Diabetes mellitus was associated in 40 % of the cases.
    [Show full text]