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Fact Sheet on Solar Elastosis

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Fact Sheet on Solar Elastosis Cancer Association of South Africa (CANSA) Fact Sheet on Solar Elastosis Introduction Solar elastosis (also known as Actinic Elastosis) is an accumulation of abnormal elastin (elastic tissue) in the dermis of the skin, and in the conjunctiva of the eye, which occurs as a result of the cumulative effects of prolonged and excessive sun exposure, a process known as photoaging. It is most commonly found on the face, lips, ears, back of the hands, forearms, scalp or neck. [Picture Credit: Solar Elastosis] Solar Elastosis Solar elastosis is a medical condition in which the skin modifies its colour (often times it is yellowish) and it becomes thicker, as a direct result of sun damage. It is especially encountered in people with fair complexion. In the case of elastosis, the collagen layer is damaged and the elastic layer overcompensates by accumulating elastin excessively. The accumulation of abnormal elastin is not only noticed on the skin but also on the eye conjunctiva. It would seem that prolonged and excessive exposure to the sun is the main culprit behind solar elastosis. Gonzaga, A.K.G., Mafra, R.P., da Silva, L.P., de Almeida Freitas, R., de Souza, L.B. & Pinto, L.P. 2020. “Actinic cheilitis (AC) is a potentially malignant lesion caused by chronic sun exposure. This study aimed to evaluate the relationship between the degree of epithelial dysplasia and morphometric findings in AC. Sixty-eight slides of AC cases were selected and classified according to the grade of epithelial dysplasia, following morphologic criteria of World Health Organization. For morphometric analysis, the slides were scanned and images were analyzed using Pannoramic Viewer software. We obtained vertical measurements of the parameters: thicknesses of the keratin layer, lamina propria and zone of solar elastosis in three selected fields. Thirty-seven (54.4%) of the analyzed cases were classified as none/mild dysplasia and 31 (45.6%) as moderate/severe epithelial dysplasia. Cases with a moderate/severe dysplasia exhibited a thicker layer of keratin (median = 0.055 mm) than none/mild dysplasia (median = 0.045 mm) (p = 0.033). No significant differences in the thicknesses of lamina propria and zone of solar elastosis were observed according to the grade of epithelial Researched and Authored by Prof Michael C Herbst [D Litt et Phil (Health Studies); D N Ed; M Art et Scien; B A Cur; Dip Occupational Health; Dip Genetic Counselling; Diagnostic Radiographer; Dip Audiometry and Noise Measurement; Medical Ethicist] Approved by Ms Elize Joubert, Chief Executive Officer [BA Social Work (cum laude); MA Social Work] May 2021 Page 1 dysplasia. A positive significant correlation between keratin layer and lamina propria thicknesses was found (p = 0.019). Based on our findings, rigorous clinical follow-up should be recommended for patients whose histopathological examination shows a greater thickness of the keratin layer.” Incidence of Solar Elastosis in South Africa The National Cancer Registry (2017) does not furnish any information regarding the incidence of Solar Elastosis. Pathophysiology of Solar Elastosis Cells within Solar Elastosis show characteristic UV-induced gene mutations. [Picture Credit: Solar Elastosis 2] Histologically Solar Elastosis share features with squamous cell carcinoma (SCC). It is an epidermal lesion characterised by: • Collections of atypical, pleomorphic keratinocytes in the basal layer which can extend to the upper granular and cornified layers. • The epidermis being abnormal in architecture, with acanthosis, parakeratosis, and dyskeratoses. Cellular atypia is present with keratinocytes varying in size and shape. • Mitotic figures being present. It has features of Bowen's disease or carcinoma in situ: • They can be distinguished more by the degree of cellular change and the extent of the lesions rather than differences in the features of individual cells. • Often, marked hyperkeratosis and areas of parakeratosis with loss of the granular layer are present. • A dense inflammatory infiltrate is usually present. Causes of Solar Elastosis Solar elastosis affects people who have had long term sun exposure and is a feature of photoageing. It affects individuals of all skin types but its yellow hue is more obvious in fair skin individuals. Solar elastosis is also a manifestation of premature skin ageing caused by smoking. Treatment of Solar Elastosis The best treatment of solar elastosis is prevention. One can prevent sunburn and the related skin conditions by protecting one’s skin whenever outdoors by wearing a broad rim hat, protective clothing, and sunscreen with SPF of at least 30. However, if one sees signs of solar elastosis, there are antiaging skin care products and treatment available. Researched and Authored by Prof Michael C Herbst [D Litt et Phil (Health Studies); D N Ed; M Art et Scien; B A Cur; Dip Occupational Health; Dip Genetic Counselling; Diagnostic Radiographer; Dip Audiometry and Noise Measurement; Medical Ethicist] Approved by Ms Elize Joubert, Chief Executive Officer [BA Social Work (cum laude); MA Social Work] May 2021 Page 2 Charles-de-Sá, L., Gontijo-de-Amorim, N.F., Rigotti, G., Sbarbati, A., Bernardi, P., Benati, D., Bizon Vieira Carias, R., Maeda Takiya, C. & Borojevic, R. 2020. Background: The major intrinsic cause of facial skin degeneration is age, associated with extrinsic factors such as exposure to sun. Its major pathologic causes are degeneration of the elastin matrix, with loss of oxytalan and elaunin fibers in the subepidermal region, and actinic degeneration of elastin fibers that lose their functional properties in the deep dermis. Therapy using autologous adipose mesenchymal stem cells for regeneration of extracellular matrix in patients with solar elastosis was addressed in qualitative and quantitative analyses of the dermal elastic fiber system and the associated cells. Methods: Mesenchymal stem cells were obtained from lipoaspirates, expanded in vitro, and introduced into the facial skin of patients submitted after 3 to 4 months to a face-lift operation. In the retrieved skin, immunocytochemical analyses quantified elastic matrix components; cathepsin K; matrix metalloproteinase 12 (macrophage metalloelastase); and the macrophage M2 markers CD68, CD206, and hemeoxygenase-1. Results: A full de novo formation of oxytalan and elaunin fibers was observed in the subepidermal region, with reconstitution of the papillary structure of the dermal-epidermal junction. Elastotic deposits in the deep dermis were substituted by a normal elastin fiber network. The coordinated removal of the pathologic deposits and their substitution by the normal ones was concomitant with activation of cathepsin K and matrix metalloproteinase 12, and with expansion of the M2 macrophage infiltration. Conclusion: The full regeneration of solar elastosis was obtained by injection of in vitro expanded autologous adipose mesenchymal stem cells, which are appropriate, competent, and sufficient to elicit the full structural regeneration of the sun-aged skin. Medical Disclaimer This Fact Sheet is intended to provide general information only and, as such, should not be considered as a substitute for advice, medically or otherwise, covering any specific situation. Users should seek appropriate advice before taking or refraining from taking any action in reliance on any information contained in this Fact Sheet. So far as permissible by law, the Cancer Association of South Africa (CANSA) does not accept any liability to any person (or his/her dependants/ estate/heirs) relating to the use of any information contained in this Fact Sheet. Whilst CANSA has taken every precaution in compiling this Fact Sheet, neither it, nor any contributor(s) to this Fact Sheet can be held responsible for any action (or the lack thereof) taken by any person or organisation wherever they shall be based, as a result, direct or otherwise, of information contained in, or accessed through, this Fact Sheet. Sources and References Consulted or Utilised Charles-de-Sá, L., Gontijo-de-Amorim, N.F., Rigotti, G., Sbarbati, A., Bernardi, P., Benati, D., Bizon Vieira Carias, R., Maeda Takiya, C. & Borojevic, R. 2020. Photoaged skin therapy with adipose-derived stem cells. Plast Reconstr Surg. 2020 Jun;145(6):1037e-1049e. Researched and Authored by Prof Michael C Herbst [D Litt et Phil (Health Studies); D N Ed; M Art et Scien; B A Cur; Dip Occupational Health; Dip Genetic Counselling; Diagnostic Radiographer; Dip Audiometry and Noise Measurement; Medical Ethicist] Approved by Ms Elize Joubert, Chief Executive Officer [BA Social Work (cum laude); MA Social Work] May 2021 Page 3 Gonzaga, A.K.G., Mafra, R.P., da Silva, L.P., de Almeida Freitas, R., de Souza, L.B. & Pinto, L.P. 2020. Actinic cheilitis: morphometric parameters and its relationship with the degree of epithelial dysplasia. Acta Histochem. 2020 Jan;122(1):151452. Epub 2019 Sep 23. DermNet NZ http://www.dermnetnz.org/dermal-infiltrative/solar-elastosis.html Konopinski, J.C., Danialan, R., Torres-Cabala, C.A., Tetzlaff,M.T., Nagarajan, P., Curry, J.L., Ivan, D., Prieto, V.G. & Aung, P.P. 2018. Melanoma coexisting with solar elastosis: a potential pitfall in the differential diagnosis between nevus and melanoma. Hum Pathol. 2018 Oct 22. pii: S0046-8177(18)30397-6. doi: 10.1016/j.humpath.2018.10.010. [Epub ahead of print] Mayo Clinic http://www.mayoclinic.org/diseases-conditions/actinic-keratosis/home/ovc-20263959 Medical Point http://medicalpoint.org/solar-elastosis/ Pain, S., Berthélémy, N., Naudin, C., Degrave, V. &
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