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United States Patent 19 11 Patent Number: 5,968,488 Wachter Et Al

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United States Patent 19 11 Patent Number: 5,968,488 Wachter Et Al USOO5968488A United States Patent 19 11 Patent Number: 5,968,488 Wachter et al. (45) Date of Patent: Oct. 19, 1999 54) DEODORIZING PREPARATIONS 5,442,048 8/1995 Meister et al. ............................ 536/20 CONTAINING CATIONIC BIOPOLYMERS, ALUMINUM HYDROCHLORATE AND FOREIGN PATENT DOCUMENTS ESTERASE INHIBITORS 0 382 150 8/1990 European Pat. Off.. 75 Inventors: Rolf Wachter, Duesseldorf, Rudolf 63/290.8082. 635 11/1988I JFishbourg Lehmann, Leichlingen; Claudia WO87/06827 11/1987 WIPO. Panzer, Grevenbroich, all of Germany WO91/O5808 5/1991 WIPO. WO91/07165 5/1991 WIPO. 73 Assignee: Henkel Kommanditgesellschaft auf Aktien, Duesseldorf, Germany OTHER PUBLICATIONS 21 Appl. No.: 09/066,358 W. Umbach, “Kosmetik”, Thieme Verlag, p. 141, et seq., 22 PCT Filed: Oct. 21, 1996 New York (1998). 86 PCT No.: PCT/EP96/04563 Gesslein, et al., HAPPI 27: 57 (1990). S371 Date: Apr. 28, 1998 O. Skaugua, d. DUrug Ccosm. InInd. 148: 24 (May,(Mav, 1991).1991) E. Onsoyen, et al., Seifen-Ole-Fette-Wachse 117: 633–37 S 102(e) Date: Apr. 28, 1998 (1991). 87 PCT Pub. No.: WO97/16164 Tronnier, et al., J. Soc. Cosm. Chem. 24; 281–290 (1973). PCT Pub. Date: May 9, 1997 Graham, et al., J. Pharm. Pharmacol. 26: 531-534 (1974). 51.51 InInt. Cl. ............................... A61A61K K 2.7/32: CO8BA61K 3,Os7/38: Primary Examiner. Shelley A. Dodson 52 U.S. Cl. .............................. 424/65. 424,68; 424400, ESEPC, "''' Szoke; Wayne C. 424/401; 536/20 s 58 Field of Search ................................ 424/65, 68,400, 57 ABSTRACT 424/401; 536/20 Adeodorant composition containing: (a) a cationic biopoly 56 References Cited mer; (b) an aluminum chlorohydrate, and (c) an esterase inhibitor. U.S. PATENT DOCUMENTS 5,411,731 5/1995 Tanaka et al. ....................... 424/78.02 19 Claims, No Drawings 5,968,488 1 2 DEODORIZING PREPARATIONS molecular weights which contain the-idealized-monomer CONTAINING CATIONIC BIOPOLYMERS, unit (I): ALUMINUM HYDROCHLORATE AND ESTERASE INHIBITORS CH2OH OH NH2 BACKGROUND OF THE INVENTION O O O Field of the Invention O This invention relates to deodorizing formulations con OH NH CH2OH taining cationic biopolymers, aluminium chlorohydrate and esterase inhibitors. In contrast to most hydrocolloids, which are negatively Discussion of Related Art charged at biological pH values, the chitosans preferably In the field of personal hygiene, deodorants are used to used are cationic compounds under these conditions. The eliminate troublesome body odors. Body odors are formed 15 positively charged chitosans are capable of interacting with by the bacterial decomposition of basically odorless oppositely charged Surfaces and, accordingly, are used in perspiration, particularly in the damp underarm regions or cosmetic hair-care and body-care formulations. Overviews under Similar conditions favorable to microorganism on this subject have been published, for example, by B. growth. Body odors can be masked by Suitable perfumes. Gesslein et al. in HAPPI 27 57 (1990), by O Skaugrud in They can also be controlled by using formulations which Drug Cosm. Ind. 148, 24 (1991) and by E. Onsoyen et al. in inhibit the actual Secretion of perspiration or its decompo Seifen-Ole-Fette-Wachse 117 633 (1991). Chitosans are Sition (so-called antihydrotics, antiperspirants or produced from chitin, preferably from the shell remains of antitranspirants). Typical examples of Such Substances are crustaceans which are available in large quantities as inex aluminium compounds, Such as aluminium Sulfate or alu pensive raw materials. Normally, the chitin is first depro minium chlorohydrate, Zinc Salts and citric acid compounds. 25 teinized by addition of bases, demineralized by addition of An Overview of these agents was published, for example, in mineral acids and, finally, deacetylated by addition of Strong Umbach (Ed.), “Kosmetik, pages 141 et seq., Thieme bases, the molecular weights being spread over a broad Verlag, Stuttgart, 1988. range. Chitosans Subsequently degraded with hydrogen per However, it is clear from everyday living that the problem oxide are preferred. Corresponding processes for the pro of odor inhibition, particularly in heat or in the event of duction of microcrystalline-chitosan are described, for bodily activity, has by no means been completely Solved. example, in WO 91105808 (Firextra Oy) and in EP-B10382 Commercial products are unable permanently to SuppreSS 150 (Hoechst). the secretion of perspiration or the formation of odors. Instead, their inhibiting effect is of limited duration and is Aluminium chlorohydrate also dependent on the extent to which perspiration is 35 The aluminium chlorohydrates of component (b) are Secreted. Accordingly, there is a constant need for improved colorless hygroscopic crystals which readily coalesce in air products which minimize the Secretion of perspiration and and which accumulate during the concentration of aqueous reduce the formation of body odors and which, at the same aluminium chloride Solutions by evaporation. Aluminium time, show increased dermatological compatibility, i.e. chlorohydrate is used for the production of antiperspirant reduced irritation potential towards particularly Sensitive 40 and deodorizing formulations and probably acts by contract skin. The problem addressed by the present invention was to ing or blocking the Sweat glands by protein precipitation provide Such products. and/or removal of moisture cf. J. Soc. Cosm. Chem. 24, 281 (1973). An aluminium chlorohydrate which corresponds to DESCRIPTION OF THE INVENTION the formula Al(OH)3Cl2.5H2O is commercially avail The present invention relates to deodorizing formulations 45 able under the name of Locrono from Hoechst AG of containing Frankfurt, FRG. This aluminium chlorohydrate is particu (a) cationic biopolymers, larly preferred for the purposes of the invention cf. J. (b) aluminium chlorohydrate and/or Pharm. Pharmacol. 26, 531(1974). (c) esterase inhibitors. 50 Esterase inhibitors The use of aluminium chlorohydrates and esterase inhibi tors of the triethyl citrate type for producing deodorizing When perspiration is present in and around the underarm and/or antiperSpirant compositions is known from the prior region, enzymes (esterases) which cleave esters and thus art. It has Surprisingly been found that cationic biopolymers, emit odor-forming Substances are activated by bacteria and preferably of the chitosan type, inhibit the activity of 55 released into the extracellular Space. The esterase inhibitors esterase-producing bacteria and that a Synergistic deodoriz of component (c), preferably trialkyl citrates, Such as trim ing effect is obtained in conjunction with the two compo ethyl citrate, tripropyl citrate, tributyl citrate and, in nents mentioned above. The biopolymers have a bacterio particular, triethyl citrate (Hydagen(R) CAT, Henkel KGaA, Static effect, i.e. the population of the germs in question is Dusseldorf, FRG) inhibit the enzyme activity and thus controlled, but not destroyed in order not to impair the 60 reduce odor formation. The free acid is probably released by biological equilibrium of the dermal flora. At the Same time, the cleavage of the citric acid ester, reducing the pH value the use of the cationic biopolymers leads to an improvement on the skin to Such an extent that the enzymes are blocked. in the dermatological compatibility of the products. Other Substances Suitable for use as esterase inhibitors are dicarboxylic acids and esters thereof Such as, for example, Cationic biopolymers 65 glutaric acid, glutaric acid monoethyl ester, glutaric acid Cationic biopolymers Suitable for use as component (a) diethyl ester, adipic acid, adipic monoethyl ester, adipic acid are preferably partly deacetylated chitins with various diethyl ester, malonic acid and malonic acid diethyl ester, 5,968,488 3 4 hydroxycarboxylic acids and esters thereof Such as, for EXAMPLES example, citric acid, malic acid, tartaric acid or tartaric acid diethyl ester. 5-Chloro-2-(2,4-dichlorophenoxy)-phenol, I. Ingredients which is marketed by Ciba-Geigy of Basel, Switzerland under the name of Irgasan(R), has also proved to be particu A) Cationic biopolymer of the chitosan type (Hydagen(R) larly effective. CMF, Henkel KGaA); 1% by weight in 0.4% by weight aqueous glycolic acid Commercial Applications B) Aluminium chlorohydrate (Locron(R) L, Hoechst AG) Cationic biopolymers have proved to be bacteriostatic for C) Triethyl citrate (Hydagen(R) CAT, Henkel KGaA) the described application. Accordingly, the present invention II. Performance tests also relates to their use-either on their own or in the form of mixtures with aluminium chlorohydrates and/or esterase The effectiveness of the formulations according to the inhibitors—for the production of deodorizing formulations. invention was representatively determined as their esterase In one preferred embodiment of the invention, the com 15 inhibiting effect. To this end, the residual activity of the test positions according to the invention may contain compo mixtures after acting on the esterase for 15 minutes in nents (a), (b) and (c) advantageously in the following quantities of 2000 ppm at pH 6 was determined parallel to an uninhibited esterase (standard=100%). Formulations F1, quantities, based on their Solids content: F2, F4, F6 and F7 correspond to the invention while for (a) 0.01 to 50, preferably 2 to 5% by weight of cationic mulations F3, F5 and F8 are intended for comparison. The biopolymers, results are set out in Table 1 below (quantities in % by (b) 1 to 50, preferably 10 to 50% by weight of aluminium weight). chlorohydrate and (c) 0.01 to 20, preferably 1 to 5% by weight of esterase TABLE 1. inhibitors, with the proviso that the quantities shown 25 add up to 100% by weight. The above figures apply to Formulations and esterase inhibition the active Substance content of the components. Components F1 F2 F3 F4 F5 F6 F7 F8 A. 4 4 4 4 4 Germ-inhibiting agents B 50 1O 50 50 50 C 6 5 5 5 5 The formulations according to the invention may contain Ethanol 2O 2O 2O 2O 2O 2O 2O Glycolic acid O.O16 O.O16 - 0.016 - 0.016 0.016 known germ inhibitors as further additives.
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