DOCSLIB.ORG

Bauabschnitt 1

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

xuT Wartenberg-Marzahn 26. 8. 2019 (Mo) – 4. 10. 2019 (Fr) 4 Uhr 1.30 Uhr Ersatzverkehr mit Bussen Replacement service by bus Bauabschnitt 1 Kalender Einschränkungen August September 2019 26 27 28 29 30 31 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Mo Di Mi Do Fr Sa So Mo Di Mi Do Fr Sa So Mo Di Mi Do Fr Sa So Wartenberg <> Springpfuhl kein S-Bahnverkehr b 0 S75 Wartenberg <> Hohenschönhausen <> Marzahn Ahrensfelde <> Springpfuhl kein S-Bahnverkehr b 0 S7 Ahrensfelde <> Marzahn <> Springpfuhl Wartenberg <> Hohenschönhausen <> Marzahn 0b S75 <> Springpfuhl Einschränkungen September 2019 Oktober 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 1 2 3 4 5 6 Mo Di Mi Do Fr Sa So Mo Di Mi Do Fr Sa So Mo Di Mi Do Fr Sa So Wartenberg <> Springpfuhl kein S-Bahnverkehr b 0 S75 Wartenberg <> Hohenschönhausen <> Marzahn Ahrensfelde <> Springpfuhl kein S-Bahnverkehr b 0 S7 Ahrensfelde <> Marzahn <> Springpfuhl b Wartenberg <> Hohenschönhausen <> Marzahn 0 S75 <> Springpfuhl Ahrensfelde/Wartenberg <> kein S-Bahnverkehr Lichtenberg <> Nöldnerplatz 0b S7 Ahrensfelde <> Marzahn <> Landsberger Allee Wartenberg <> Hohenschönhausen <> Marzahn 0b S75 <> Springpfuhl <> Lichtenberg <> Rummelsburg <> Ostkreuz Bitte beachten Sie: vom 31.08. (Sa) ca. 15 Uhr durchgehend bis 02.09.2019 (Mo) 1:30 Uhr fährt die S7 im Abschnitt Ahrensfelde <> Lichtenberg nur im 20-Minutentakt. Die S7 fährt (auch im Nachtverkehr Sa/So) von Ahrensfelde bis Springpfuhl 8 Minuten früher, hat in Springpfuhl 5 Minuten Aufenthalt und fährt von Springpfuhl bis Lichtenberg 3 Minuten früher. In der Gegenrichtung (jedoch nicht im Nachtverkehr Sa/So) hat die S7 nach Lichtenberg/Ahrensfelde in Ostbahnhof 5 Minuten Aufenthalt, fährt von Ostbahnhof bis Lichtenberg 5 Minuten später, hat in Lichtenberg weitere 3 Minuten Aufenthalt und fährt von Lichtenberg bis Ahrensfelde 8 Minuten später. In der Nacht 01./02.09. (So/Mo) bestehen von ca. 21 Uhr bis 1:30 Uhr umfangreichen Einschränkungen zwischen Friedrichstraße <> Olympiastadion/Potsdam Hbf. 2 Inhalt Seite 4 Sehr geehrte Fahrgäste, Seite 5 Dear Passengers, Seite 6 Einschränkungen im S-Bahnverkehr (S75) Seite 7 Linienführung und Haltestellen des Ersatzverkehr mit Bussen Bus S75 Seite 7 Umfahrungsmöglichkeiten Seite 8 weitere zeitweisen Einschränkungen im S-Bahnverkehr (S7) Seite 9 Linienführung und Haltestellen des Ersatzverkehr mit Bussen Bus S7 und S75 Seite 10 Ausblick auf weitere Bauarbeiten in diesem Bereich Haltestellen des Ersatzverkehrs mit Bussen (Karten) Seite 11 Wartenberg Seite 12 Hohenschönhausen Seite 13 Gehrenseestraße Seite 14 Raoul-Wallenberg-Straße Seite 15 Marzahn Seite 16 Ahrensfelde Seite 17 Mehrower Allee Seite 18 Poelchaustraße Seite 19 Springpfuhl Tarifhinweis: Fahrausweise des Kurzstreckentarifs werden auf dem Streckenabschnitt Raoul-Wallenberg-Straße <> Marzahn <> Poelchaustraße <> Springpfuhl <> Friedrichsfelde Ost <> Lichtenberg bis zu maximal 5 Stationen sowie zusätzlich im Ersatzverkehr Bus S75 anerkannt. Die Entwertung muss dabei zwingend in Raoul-Wallenberg-Straße, Marzahn, Poelchaustraße, Springpfuhl, Friedrichsfelde Ost oder Lichtenberg bzw. Wartenberg, Hohenschönhausen oder Gehrenseestraße erfolgen. 3 Sehr geehrte Fahrgäste, vom 26.08. (Mo) 4 Uhr durchgehend bis 14.11.2019 (Do) 1:30 Uhr wird der Streckenabschnitt Wartenberg <> Hohenschönhausen <> Springpfuhl für den S-Bahnverkehr gesperrt. In dieser Zeit werden die Gleise erneuert und moderne Zugsicherungstechnik (ZBS) installiert. Dafür sind umfangreiche Arbeiten, wie z.B. das Aufstellen von Signalen und der Einbau von Achszählern erforderlich. Die S75 fährt bis 04.10.2019 (Fr) 1:30 Uhr als S7 Ahrensfelde <> Ostbahnhof, zusammen mit der regulären S7 besteht dadurch tagsüber bis ca. 21 Uhr ein 5-Minutentakt. Im Abendverkehr wird der Abschnitt Ahrensfelde <> Ostbahnhof durch eine zusätzliche Fahrt innerhalb von 20 Minuten, im Nachtverkehr Fr/Sa und Sa/So der Abschnitt Springpfuhl <> Lichtenberg auf einen ungefähren 15-Minutentakt verdichtet. Ersatzverkehr mit Bussen wird zwischen Wartenberg <> Marzahn eingerichtet, nutzen Sie bitte zwischen Marzahn <> Ostbahnhof die S7. Logistikfahrten zur und von der Baustelle erfolgen mit Arbeitszügen über Ahrensfelde. Dafür ist an zahlreichen Tagen (siehe Kalender) zusätzlich der Abschnitt Ahrensfelde <> Marzahn <> Springpfuhl zeitweise (Mo-Fr jeweils 10:30 bis 13 Uhr, Sa+So jeweils 10 bis 15 Uhr) sowie an zwei Tagen (14.09. und 15.09. (Sa+So)) ganztägig gesperrt. Die S7 fährt dann Springpfuhl <> Potsdam Hbf (im 10-Minutentakt), die S75 entfällt. Ersatzverkehr mit Bussen (Bus S7) wird auf der Strecke Ahrensfelde <> Springpfuhl eingerichtet, der bestehende Ersatzverkehr (Bus S75) Wartenberg <> Marzahn wird bis/ab Springpfuhl verlängert. Wir empfehlen, auch die zahlreichen Umfahrungsmöglichkeiten mit dem Bahnregionalverkehr (RB12, RB24, RB25), TRAM (M4, M6, M8, M17, 16) oder Buslinien zu nutzen (siehe Seite 7). Über die Einschränkungen und Ersatzverkehrsangebote im Zeitraum bis 04.10.2019 (Fr) 1:30 Uhr informiert dieser Bauflyer. Ab 04.10.2019 (Fr) 4 Uhr wird die Baustelle wesentlich erweitert, dann sind auch die S5 auf dem Abschnitt Wuhletal <> Ostkreuz, die S7 auf dem Abschnitt Ahrensfelde <> Nöldnerplatz und die S75 auf gesamter Linie betroffen. Ein weiterer Bauflyer informiert ab September über die Einschränkungen und Ersatzverkehre. Einen Ausblick auf weitere Bauarbeiten in diesem Bereich enthält auf dieser Bauflyer auf Seite 10. Es kommen überwiegend barrierefreie Busse zum Einsatz. Bitte haben Sie Verständnis, sollten einzelne Fahrten nicht barrierefrei angeboten werden können. Die Beförderung von Kinderwagen, Rollstühlen und Fahrrädern, ist nur im Rahmen vorhandener Kapazitäten möglich. Dabei haben Kinderwagen und Rollstühle Vorrang. Bitte erwerben Sie Ihre Fahrausweise möglichst vor Fahrtantritt, in den Bussen ist leider kein Erwerb von Fahrausweisen möglich. Wir empfehlen, kurz vor Fahrtantritt eine Reiseverbindung aus den elektronischen Fahrplanauskunftsprogrammen unter sbahn.berlin, www.vbb.de oder www.bahn.de abzurufen. Die Daten sind auch per App verfügbar. Hier werden Ihnen alternative Routen angezeigt. Ihre S-Bahn Berlin GmbH 4 Dear Passengers, The line between Wartenberg <> Hohenschönhausen <> Springpfuhl will be completely closed from 4 am on 26 August (Monday) until 1.30 am on 14 November 2019 (Thursday). S-Bahn services will not run during this period, as we are renovating the tracks and installing a modern train protection system (Berlin S-Bahn train control system). This work includes a large number of measures, such as the installation of signals and axle counters. S75 services will run as S7 trains between Ahrensfelde <> Ostbahnhof until 1.30 am on 4 October 2019 (Friday). Together with regular S7 trains, this will create a service frequency of every 5 minutes until approx. 9 pm. There will be one additional train within a 20-minute period during the evening on the Ahrensfelde <> Ostbahnhof section of the route, and trains will run on the Springpfuhl <> Lichtenberg section roughly every 15 minutes during the night from Friday - Saturday and Saturday - Sunday. There will be a rail replacement service with buses S7 between Wartenberg <> Marzahn. Please use the S7 between Marzahn <> Ostbahnhof. Work trains providing logistics services to and from the construction site will be routed via Ahrensfelde. As a result, the Ahrensfelde <> Marzahn <> Springpfuhl section of the route will also be closed on a considerable number of days (see calendar). The closures are as follows: 10.30 am – 1 pm on Monday - Friday, 10 am – 3 pm on Saturday - Sunday, and all day on 14 September (Saturday) and 15 September (Sunday). At these times, the S7 will run between Springpfuhl <> Potsdam Hbf (10-minute service frequency), and there will be no S75 service. There will be a rail replacement service with buses for the S7 on the Ahrensfelde <> Springpfuhl route, and the existing rail replacement service for the S75 between Wartenberg <> Marzahn will be extended to/from Springpfuhl. We recommend that passengers use the many alternative transport options, such as the RB12, RB24 and RB25 local trains, M4, M6, M8, M17 and 16 trams, and bus lines (see p. 7). This flyer provides information about restrictions to services and alternative transport options in the period until 3 October 2019 (Thursday). More extensive construction work is planned as of 4 October 2019 (Friday), affecting the S5 between Wuhletal <> Ostkreuz, the S7 between Ahrensfelde <> Nöldnerplatz and the entire S75 route. We will publish another flyer with information about the resulting transport restrictions and alternative options. A look ahead at further upcoming construction work in the area is available on p. 10 of this flyer. Mainly barrier-free vehicles will be used for replacement services. We ask for your understanding should barrier- free vehicles be unavailable for any part of your journey. Transporting pushchairs, wheelchairs and bicycles is only possible where there is space on the bus, with priority being given to pushchairs and wheelchairs. Please purchase your ticket prior to travelling, since tickets are not available for purchase on the buses. Before you start your journey, we recommend that you check service availability in the electronic timetable information at sbahn.berlin, www.vbb.de or www.bahn.de. The information you need is also available on the corresponding apps and mobil.s-bahn-berlin.de. These online resources can show you alternative routes to your destination. S-Bahn Berlin GmbH 5 26.8. (Mo) 4 Uhr durchgehend bis 4.10.2019 (Fr) 1:30 Uhr gesperrt
Recommended publications
  • Author Index

    Author Index

    Neuropsychopharmacology (2011) 36, S450–S482 & 2011 American College of Neuropsychopharmacology. All rights reserved 0893-133X/11 S450 www.neuropsychopharmacology.org Author Index A Alcantara, Lyonna F. S431 Alda, Martin . S391 Aarde, Shawn A. S441 Alegria, Dylan . S398 Abazyan, Bagrat. S214 Alexander, Kathleen S . S209 Abazyan, Sofya . S214 Alexander-Bloch, Aaron F . S272 Abbott, Chris. S386 Al-Hasani, Ream . S440 Abbs, Brandon. S314 Alia-Klein, Nelly . S376 Abdallah, Chadi G . S139 Alim, Tanya. S304 Abdel-Hamid, Mona. .S135 Allard, Carolyn B. S139 Abel, Ted . S223 Allen, John . S185, S186, S394 Abelson, James . S144, S406 Allen, Katherine. S134 Abend, Rany . S110 Allen, Wade M . .S171 Abercrombie, Heather C. S158 Almeida, Jorge RC . S290 Aberdam, Daniel . S218 Almli, Lynn M. S256 Abi-Dargham, Anissa . .S20, S282 Almog, Orna . S429 Abrams, Debra J . S129 Altshuler, Lori . S116, S248, S396 Abulseoud, Osama A . S343 Aluisio, Leah . .S191 Aceti, Max. S84 Alvarez-Estrada, Miguel . S179 Acheson, Shawn K . S306 Aman, Michael G. S228 Achtyes, Eric . S232 Amar, Shirly . S414 Adams, David H . .S132 Amaral, David . S31 Adams, Matthew . .S331 Amir, Nader . S143 Addington, Jean. .S10, S240 Amita, Hidetoshi . S447 Adelekun, Adesewa E . S436 Amy, Easton . S182 Adleman, Nancy E . S386 Anand, Amit . .S153 Adler, Caleb M . S159, S297 Anand, Reena . S391 Adler, Lenard . S230 Anastasio, Noelle . S19, S310 Adli, Mazda. .S161 Anders, Martin . S167 Agam, Galila . .S85, S414, S429 Andersen, Susan . .S50, S439 Agarwal, Vishesh . S167 Anderson, Adam . .S171 Aghajanian, George . S62 Anderson, Colleen . .S353 Agid, Ofer . S103 Anderson, George . S198 Agster, Kara L . S83 Anderson, Jeffery . .S153 Ahmari, Susanne E . S75 Anderson, Stewart J . .S115 Ahmed, Saeeduddin .
  • Train Simulator - Right Through Berlin

    Train Simulator - Right Through Berlin

    Train Simulator - Right through Berlin © Historical S-Bahn Berlin e.V. 2020 Page 1 Train Simulator - Right through Berlin Manual "Mitten durch Berlin" - Operation Series 476 Table of contents Table of contents ....................................................................................................... 2 0. authors ................................................................................................................ 3 1. introduction .......................................................................................................... 3 2. system requirements .............................................................................................. 4 3. the driver's cab ..................................................................................................... 5 4. upgrading .......................................................................................................... 10 4.1 Train is cold (full upgrade) .............................................................................. 10 4.2 Transfer of trains from other Tf ......................................................................... 10 4.3 Train is fully upgraded .................................................................................... 10 4.4 Change of driver's cab ................................................................................... 11 5. door control ....................................................................................................... 11 6. driving and braking ...........................................................................................
  • ICON S Conference 17 – 19 June 2016 Humboldt University Berlin

    ICON S Conference 17 – 19 June 2016 Humboldt University Berlin

    Berlin Berlin 2016 ICON S CONFERENCE 17 – 19 JUNE 2016 HUMBOLDT UNIVERSITY BERLIN We extend a warm welcome to all participants in the 2016 Annual Meeting of ICON S, the International Society of Public Law. This will be our largest Annual Meeting since the foundation of the Society in 2013. The panels, roundtables and plenary events address the Conference’s overarching theme of “Borders, Otherness and Public Law” and other topics at the heart of contemporary public law inquiry. We are grateful to our Berlin hosts for their relentless hard work and creativity in putting together such a mega-sized event, and we thank our sponsors for their generous support. Most of all, we thank you, the ICON S members, for your overwhelmingly positive response to the call for papers this year, and for volunteering your time and energy to promote the success of the Society and its annual conference. Together, we have created what we believe is a first-rate, intellectually appealing program featuring scholars, jurists and policy makers from various disciplines and from literally four corners of the world. We hope that you enjoy it thoroughly! Gráinne de Búrca ( New York University ) and Ran Hirschl ( University of Toronto ) Co-Presidents, ICON S, the International Society of Public Law S Conference ICON WElcomE statEMEnts 1 I WELcoME STATEMENTS 1 II ICON S INAUGURAL GOVERNANCE 3 III SCHEDULE 4 IV MAP OF CONFERENCE VENUES 6 V PLENARY EVENTS 7 VI CONCURRING PANELS 15 a OVERVIEW 16 b PANEls SEssion I 26 c PANEls SEssion II 43 D PANEls SEssion III 77 E PANEls SEssion IV 110 F PANEls SEssion V 143 VII ICON S WP CONFERENCE ProcEEDINGS SERIES 179 VIII SERVICE 180 IX PARTICIPANTS 190 ICON S CONFERENCE 17 – 19 JUNE 2016 HUMBOLDT UNIVERSITY BERLIN We extend a warm welcome to all participants in the 2016 Annual Meeting of ICON S, the International Society of Public Law.

  • HERCULES2021 22 February > 26 March, 2021

    http://hercules-school.eu/ nd th HERCULES2021 22 February > 26 March, 2021 CONTENTS ORGANISATION ………………………………………………………………………… p. 3 GENERAL INFORMATION ……………………………………………………….... p. 7 PRACTICAL INFORMATION ………………………………………………………. p. 8 PROGRAMME OF GRENOBLE Planning Session A - Physics and chemistry of condensed matter - general schedule ………........................................................................ p. 15 - practicals / labs / tutorials ……………………………………………………………… p. 19 Planning Session B - Biomolecular structure and dynamics - general schedule ………........................................................................ p. 25 - practicals / labs / tutorials ……………………………………………………………… p. 29 PROGRAMME OF PARTNERS SITES ALBA + European XFEL ……………………………………………………………………………. p. 36 Elettra/FERMI ……………………………………………………………………………………….... p. 39 SLS/SINQ …………………………………………………………………………………………………. p. 43 KIT + European XFEL ……………………………………………………………………………..… p. 46 LECTURERS Lecturers of Grenoble’s programme…………………………………………………………. p. 49 Lecturers of Partners’ programme……………………………………………………………. p. 50 INSTRUCTORS OF PRACTICALS Instructors of Grenoble’s programme……………………………………………………….. p. 51 Instructors of Partners’ programme………………………………………………………….. p. 53 2 HERCULES2021 22nd February > 26th March, 2021 ORGANISATION ORGANISED BY: Université Grenoble Alpes (UGA) Grenoble INP SCIENTIFIC ADVISORY COMMITTEE M. ALTARELLI, DESY Hamburg P. KING, ISIS Didcot M. A. G. ARANDA, ALBA Barcelona G. MARGARITONDO, EPF Lausanne M. BALLAUF, University of Bayreuth Y. PETROFF,
  • TS2020 – Class 481

    TS2020 – Class 481

    TS2020 – Class 481 Typ Train Simulator 2020 - Addon Autor Benjamin Ebrecht Version 1.04 Datum 01.08.2020 Kontakt [email protected] Preface Dear Customer, thank you for your interest in our product “Die Baureihe 481”. With this Add-on you have purchased a very special realisation, as it is our very first to be based upon a vehicle model series made from scratch in the DTG Train Simulator. We have created a completely new, modular script- system to replicate the specific functions of the Berlin S-Bahn, following in an appropriately long time of development. The time was well spent: next to many very detailed characteristics like flickering lights and correctly calculated switching sparks, we also could implement entirely new systems such as an independent simulation of passengers for realistically packed trains and an extendable, fully functioning IBIS (Integrated-Board-Information-System) for the destination display and announcements. Another specialty is the fact that, in addition to the vehicle, we also managed to put a whole route into the package. Cheers to Jan Bleiß! He allowed us take the S25 part of his Add-on route “Berlin- Leipzig” and fit it to our needs for this package. Together with him, we look forward to see the fully finished S25 (to Henningsdorf); announced for 2020, with this route our vehicle will be able to fully play its potential… As usually, we have added some local colour to our scenarios and as a further addition the S-Bahn classes 475 (“Stadtbahner) and 480 (“Toaster”) are included in the package. Please note the extensive contents and complex vehicle functions of this manual.
  • 2021 GL RE Roll Before OB

    2021 GL RE Roll Before OB

    City of Berlin, Green Lake County 2021 Completed Real Estate Assessment Roll Manufacturing values suppressed Sorted by tax key number Owner Property Description Districts Class Acres Land Impts Total 206-00001-0000 179 N Adams Ave School 0434 G1 0.000 $13,900 $113,300 $127,200 Moraine Park Kenneth J. Kudlak LOT 1 CERTIFIED SURVEY MAP 2678 Totals 0.000 $13,900 $113,300 $127,200 Nina M. Kudlak 179 N Adams Ave Berlin, WI 54923 Section: 3 Acres: 0.000 206-00002-0000 175 N Adams Ave School 0434 G1 0.000 $15,100 $140,500 $155,600 Moraine Park Ashley K. Pirkey ORIGINAL PLAT S 66' OF LOT 1 & 2 W 14' OF N 72.5' Totals 0.000 $15,100 $140,500 $155,600 Zebulun L. Pirkey LOT 2 BLK 1 175 N Adams Ave Berlin, WI 54923 Section: 3 Acres: 0.000 206-00003-0000 106 E Moore St School 0434 G1 0.000 $14,200 $67,000 $81,200 Moraine Park Catherine E. Switon ORIGINAL PLAT N1/2 LOTS 3 & 4 BLK 1 Totals 0.000 $14,200 $67,000 $81,200 106 E Moore St Berlin, WI 54923 Section: 3 Acres: 0.000 206-00004-0000 180 N Wisconsin St School 0434 G1 0.000 $14,200 $70,800 $85,000 Moraine Park David C. Hardel ORIGINAL PLAT S1/2 OF LOTS 3 & 4 BLK 1 Totals 0.000 $14,200 $70,800 $85,000 420 River Dr Berlin, WI 54923 Section: 3 Acres: 0.000 206-00005-0000 170 N Wisconsin St School 0434 G1 0.000 $22,100 $160,800 $182,900 Moraine Park Jerry J.
  • O-Ring Guide

    O-Ring Guide

    O-RING GUIDE // ZATKOFF.COM Failure, improper selection or improper use of products or systems, the user, through his or her the products and/or systems described herein or own analysis and testing, is solely responsible related items may cause death, personal injury or for making the final selection of the products and property damage. systems and assuring that all performance, safety and warning requirements of the application are met. This document and other information from Zatkoff Seals & Packings provides product and/or system The products described herein, including without options for further investigation by users having limitation, product features, specifications, designs, technical expertise. It is important that you analyze availability and pricing, are subject to change by all aspects of your application and review the Zatkoff Seals & Packings at any time. information concerning the product or system in the current product catalog. Due to the variety of operating conditions and applications for these OFFER OF SALE The items described in this document are hereby Copyright © 2019, Zatkoff Seals & Packings, offered for sale by Zatkoff Seals & Packings. This Farmington Hills, MI. All rights reserved. offer and its acceptance are governed exclusively by the provisions contained in Zatkoff Seals & Packings’ “Offer of Sale” located at www.zatkoff.com/terms. WARNING: These products can expose you to chemicals including carbon black (airborne and extracts), antimony trioxide, titanium dioxide, silica (crystalline), di(2-ethylhexyl)phthalate,
  • Detailed Venue Information

    Detailed Venue Information

    HOw TO gET TO THE TU BERLIN conference Venues how to get to the tu BerlIn from hAnnoVer (A2) AnD leIpzIg, nuremBerg: Take the motorway A10 (Berlin Ring) to the Drewitz The 7th SIIT conference and the BITKOM Reception will be ... By puBlIc trAnsport motorway junction, then the AVUS (A 115) to Berlin- hosted at the faculty of Architecture | Berlin Institute of Berlin has multiple means of public transport, which might Zentrum. At the Funkturm follow the signs to wedding, but Technology (TU Berlin) | A 151 and Foyer of the Architecture be confusing for first-time visitors. generally, four means of then take the first exit to Kaiserdamm. Turn left at the end Building | Straße des 17. Juni 152 transport are relevant to know: of the slip road to turn onto the Kaiserdamm boulevard (later Bismarckstrasse). Continue over the traffic island into Lunch Break will be at café campus | Berlin Institute of U-Bahn: The Berlin U-Bahn is an equivalent to the Strasse des 17 Juni, and the Main Building of the TU Berlin Technology (TU Berlin) | Marchstraße 6 - 8 Paris Metro or the London Underground. As the is on your right after 100 yards. name implies it mostly travels underground. Sta- The DIn-DKe reception will be hosted at the roof terrace of tions and trains can be identified by a large blue U. the DIN building | Burggrafenstraße 6 ... By trAIn S-Bahn: The Berlin S-Bahn is a complementary means At Berlin Central station take a regional train (RE1, RE2, of transport. It is *not* the subway even though RE7, RB10, RB14) or S-Bahn (S5, S7, S75, S9) to Zoologischer the S might imply this.
  • Existing Pond Preliminary Plat Of

    Existing Pond Preliminary Plat Of

    PRELIMINARY PLAT Survey No. 17-0034 OF 1.25" Rebar (Set) Part of the Southeast 1/4, Northeast 1/4, Northwest 1/4, and Southwest 1/4 of the Found 1" Iron Pipe Southeast 1/4 of Section 31 and part of the Northwest 1/4 of the Southwest 1/4 of Section 32, Township 6 North, Range 20 East, City of New Berlin, Waukesha County, Wisconsin. Set 1" Iron Pipe Found - 3/4" Rebar Telephone Pedestal N89°07'07"E 2634.90' MON. TO MON. Water Valve NORTH LINE OF SE 1/4 SEC. 31 EAST 1/4 COR. SEC. 31-6-20 197.99' 765.22' CONC. MON. W/BRASS CAP 1671.69' 118.43' Hydrant LANDSCAPING N 347,023.36 N0°54'07"E CENTER 1/4 COR. SEC. 31-6-20 1. Landscaping within the Right of Way shall be the E 2,490,498.91 General Manhole 123.64' 114.10' CONC. MON. W/SEWRPC BRASS CAP responsibility of the Homeowner's Association. N 346,982.83 60' x 60' VISION 2. Landscaping within the Right of Way is at risk of Sanitary Sewer Manhole E 2,487,864.32 N41°21'32"W 216.19'CORNER removal without replacement by the city. 66.00' EASEMENT Water Manhole or Well 333.57' LAWRENCE L. & NANCY A. S41°21'32"E 216.19' SCHMIDT Wetlands NBC 1279999 V.C. 60'x60' Vision Corner 15' UTILITY EASEMENT Indicates NO ACCESS R/W VARIES 66.00' N48°38'28"E 808.08 Soil Boring FLIPCO INC. N89°20'48"E 440.50 CTH ES (NATIONAL AVE) 536.00 S0°32'58"E NBC 1276994 TREE 618.44' C26 PRESERVATION C10 EASEMENT THE PUBLIC THE 202.28' DEDICATED TO DEDICATED S15°12'35"W 615.78 FND.
  • Structure–Activity Relationships of Benzothiazole-Based Hsp90 C

    Structure–Activity Relationships of Benzothiazole-Based Hsp90 C

    pharmaceutics Article Structure-Activity Relationships of Benzothiazole-Based Hsp90 C-Terminal-Domain Inhibitors Jaka Dernovšek, Živa Zajec, Martina Durcik , Lucija Peterlin Mašiˇc,Martina Gobec, Nace Zidar and Tihomir Tomašiˇc* Faculty of Pharmacy, University of Ljubljana, AškerˇcevaCesta 7, 1000 Ljubljana, Slovenia; [email protected] (J.D.); [email protected] (Ž.Z.); [email protected] (M.D.); [email protected] (L.P.M.); [email protected] (M.G.); [email protected] (N.Z.) * Correspondence: [email protected] Abstract: Heat shock protein 90 (Hsp90) is a chaperone responsible for the maturation of many cancer-related proteins, and is therefore an important target for the design of new anticancer agents. Several Hsp90 N-terminal domain inhibitors have been evaluated in clinical trials, but none have been approved as cancer therapies. This is partly due to induction of the heat shock response, which can be avoided using Hsp90 C-terminal-domain (CTD) inhibition. Several structural features have been shown to be useful in the design of Hsp90 CTD inhibitors, including an aromatic ring, a cationic center and the benzothiazole moiety. This study established a previously unknown link between these structural motifs. Using ligand-based design methodologies and structure-based pharmacophore models, a library of 29 benzothiazole-based Hsp90 CTD inhibitors was prepared, and their antiproliferative activities were evaluated in MCF-7 breast cancer cells. Several showed Citation: Dernovšek, J.; Zajec, Ž.; low-micromolar IC , with the most potent being compounds 5g and 9i (IC , 2.8 ± 0.1, 3.9 ± 0.1 µM, Durcik, M.; Mašiˇc,L.P.; Gobec, M.; 50 50 Zidar, N.; Tomašiˇc,T.