Index

AA, see Arachidonic acid AMP, see Adenosine monophosphate Abortion Anaphylaxis, 2, 13, 264 and prostaglandin, 177-178 Angiotensin, 16, 18 4-Acetamidophenol, 8, 9,219,220, 321 Anoxia, 28 Acetylcholine, 27, 30,61 Antibody, humoral response, 283-285 Acid phosphatase, 14, 258 Antihistamine, 18 Acidic nonsteroidal anti-inflammatory drug Antimycin, 301 (AID), see Aspirin, Indomethacin, Antioxidants, 262 Phenylbutazone Antipyrine, 222 Adenosine diphosphate (ADP), 224-225, Arachidonic acid (AA), 2-5, 15,26, 248,297-301,305,313,315,329 163-165,206,215,220,225-242, competition with prostaglandin E" 306- 299,328-329,333-334 307 and lipoperoxidation, 228 and platelets, 224 and platelets, 234-242 Adenosine mono phosphate (AMP), cyclic, Aspirin, 69, 84, 222, 235, 320-322, 327 49,51-55,59,87-89,277,281, action, mechanism of, 2-3 285,286 in vivo, 323-324 inhibition, 314 and prostaglandins, 1-47 phosphodiesterase, 309-31 ° prostaglandin synthetase inhibited, 2, 4 and prostaglandins, 51-55 and teratogenicity, 193 regulation, 307-311 ATP, see Adenosine triphosphate significance, 311-315 Atropine, 18,27 Adenosine nucleotide, 224 Avoidance behavior, 164 Adenosine triphosphatase (ATPase), 84-87 Aziothioprine, 9 Adenosine triphosphate (ATP), 53, 55, 84-87,220,223,311,319 Bee venom, 209, 210, 213, 226 Adenylate cyclase, 49, 51-55, 87, 88, 307 Behavior and prostaglandins, 51-55 and prostaglandins, 159-169 Adenylate kinase, 85 Blastocyst Adjuvant, Freund's, 255 and prostaglandins, 176 ADP, see Adenosine diphosphate Blood flow Adrenaline, 30, 314 autoregulation, 35-36 AID, see Acidic nonsteroidal anti- inflam• local regulation, 34-38 matory drugs Bothrops jaracana venom, 207, 213, 217, Aldosterone, 9 228, 246

345 Index

Bradykinin, 12, 13, 16, 18-21,206,208, 2,3-Dimercaptopropanol, 222 219-224,245 Dinitrophenol, 30 Brain Direct lytic factor (DLF), 215, 216 function and prostaglandins, 158 Dithiothreitol, 220 prostaglandin metabolism in, 159 DLF, see Direct lytic factor Brunchoconstriction, 219, 255 D.L substance, 208 in guinea pig in vitro, 221-222 DPN-hydroxyprostanoate oxidoreductase in vivo, 219-221,224,230 (pGDH), see Prostaglandin dehy• drogenase Calcium depletion, 83 Eicosapentaenoic acid, 164,165 flux, 87 5,8,11, 14-Eicosatetraynoic acid, (ETA), 33 pool,83 Eicosatrienoic acid, 164, 165 Candida albicans, 285 Endoperoxidase, cyclic, 330-332 Carcinoma Endoperoxide, cyclic, 11, 12 medullary of thyroid gland, 50-51 Endotoxin, 37 Cardiotoxin, 215 Enterotoxin Carrageenin, 13,24,211-213,224,243-244 of Escherichia coli, 61 edema by, 260, see Rat paw edema Epinephrine, 11, 16,88,298 Cation Erythema, 18 divalent, 81-84 ultraviolet, 218 monovalent, 81 Erythrocyte, 248-252 Cellulose sulfate, 13 cation exchange, 81-84 2-Chloroadenosine, 301 deformability, 77-80, 88 Chloroquine, 10, 216 hemoglobin, 89-91 Chlorpromazine, 163 hemolysis, 80, 251 Chymotrypsin, 210, 245 induced, 249 Clofibrate, 9 mature, 75-98 Cobra venom, 207, 209 pathology, 91-93 Collagen, 225, 252, 299, 317, 318, 322-323 properties, mechanical, 77-80 and platelets, 248 and prostaglandins, 76-77, 84-89 and thrombocytopenia, 248 sensitivity to prostaglandin, 79 Compound 48/80, 13,209,210 sickling, 89-91 Contact dermatitis, 14 ET A, see 5,8,11 ,14-Eicosatetraynoic acid Crotalus venom, 226 Ethanol,23 Curcumin,218 N-Ethylmaleimide, 301, 311 Cyproheptadiene, 214, 217 DL-Cysteine, 237 Fenamate, 24 Fenclozic acid, 8 2- Deoxy-D-glucose, 301 Fever, 15, 22-24 Development Flagellin, bacterial, 32, 49 early conceptus, 176-178 cleavage, 34-35 embryonic, 175-203 Fludrocortisone, 9 fetal, 175-203 Flufenamic acid, 6, 222 human, 188-190 Fluorindomethacin, 5 and prostaglandins, 175-203 Freund's adjuvant, 255 teratogenicity, 178-188 Dexamethasone, 9 Diarrhea, 50 Glucose oxidation, 58-60 Diferuloylmethane, 218 and prostaglandins, 60 Digitonin, 23 iJ-Glucuronidase, 10, 11, 14, 258 Dihomo"'}'-linolenic acid, 238 Granuloma formation, 22

346 Index

Hemoglobin, 89-91 Kallikrein, 206, 207, 210, 224, 243 sickling, 89-93 Kidney, 34-36 Hemolysis, 80, 251 Kininogen, 224 Hexobarbi tone Kininogenase, 223 sleep-time in mice, 160 Histamine, 13, 18-22, 29, 210-211, 252,254 and immunoglobin E,280-282 Labor nascent, 13 induced by prostaglandins, 175, 189 Histidine decarboxylase, 2, 12 Lactic dehydrogenase, 258 Hormone, luteinizing, 68 Leptazo1, see Pentylenetetrazol Hyaluronidase, 215 Leukocyte migration, 22 Hydrocortisone, 9 Linoleic acid, 261 Hydroquinone,220 Lipid peroxide, 218 Hydroxybenzoic acid, 9 Lipolysis, 32-33 15-Hydroxy(15-0H)prostaglandin dehy- Lipoperoxidation, 238-239 drogenase, see Prostaglandin dehy• and inflammation, 218 drogenase Lipoperoxide,234-242 5-Hydroxytryptamine, 12,13,19,20,23, aliphatic, 261 24,314 generation, 261 Hyperalgesia, 20 hypothesis, 260-262 Hypersensitivity Luteolysin,32 immediate, 280 Luteolysis,191 type III immune complex, 285 Lymphocyte Hypotension, 222, 231 B, 278, 279, 283 cytolytic activity, 282-283 proliferation, 286-287 T, 278, 279,284,286 Ibuprofen, 6 Lysolecithin, 207,208,215 Immunoglobulin E, 252 release of histamine, 280-282 Immunology Macrophage function, 285-286 and prostaglandins, 277-291 Malonaldialdehyde, 239 speculations on, 287-289 Indomethacin, 2-11, 27-32, 35, 37, 69, 84, Malondialdehyde, 11 Mast cell, 252-257 222,235,240,320,321,327 Meclofenamic acid, 6, 9, 30, 35, 222, 224, and pregnancy, 193 321 and tetratogenicity, 193 Inflammation, 1-47,286 Mefenamic acid, 6, 9 anti-inflammatory agents, 3-12, see 2-Mercaptoethanol, 220, 223 Aspirin, Indomethacin, Phenyl• Methylsergide, 18 butazone Muscle tone, 27-30 and Iipoperoxida tion, 218 by prostaglandins, 12- 23 Inflammatory mediator, putative, 205-275 Naja naja venom, 207-209, 246 anti-inflammatory drugs, 248-263 Naja nigricollis venom, 16,213, 216, 226, and drugs, 210-248 246 history, 207-210 Naproxen, 6, 7 Inhibition, paradoxical, 220, 221 Nephrotoxicity, 26 Iodine Neurotransmission and prostaglandin, 56-59 and prostaglandins, 158 and thyroid hormone, 55-58 Neutrophil function, 285-286 Iodoprotein, 59 Niflumic acid, 6, 9 Isobutylphenylacetic acid, 222 Nociception, 21 Isoprenaline, 22 Noradrenaline, 18,33,35

347