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Inflammatory Drug Abbreviations used: AR(s), adverse hepatotoxicity, 17 reaction(s); ADR(s), adverse drug manufacturers, 9 reaction(s); NSAID(s), non-steroid anti­ amorfazone, trade mark names and inflammatory drug(s) manufacturers, 9 Amuno, generic name and manufacturer, 12 anaemia absorption interactions, drug, 180-1 aplastic, 83 acemetacin, trade mark names and report rate, 33 manufacturers, 8 haemolytic, 84-5 acetyl salicylic acid, see Aspirin in rheumatoid patients, inappropriate action, drug, ~ pharmacoactivity therapy, 250 activation (of drugs), 243-5, 246, 247 anaphylaxis/anaphylactoid reactions, 17, pathway, 244 81 Actol, generic name and manufacturer, 13 Anaprox, generic name and manufacturer, Actosal, generic name and manufacturer, 13 9 angioedema, 6 acyl-coenzyme A formation, 221-2 angiotensin-converting enzyme, 195, 196 adjuvant induced arthritis, ~ inhibitors arthritis function, 195 Af1oxan, generic name and manufacturer, NSAID interactions with, 195-200 14 animal(s) age see also elderly experimentation, ethics of, 267 gastrointestinal susceptibility re­ inter species differences in lated to, 164, 286-8 propionate chiral inversion, use of anti-arthritics correlated 222-3, 223 with, 152 Ansaid, generic name and manufacturer, aged, the, ~ elderly 11 agranulocytosis antacids, 292 incidence, 7, 100-2 passim effect on drug absorption, 180, 181 in Sweden, 66, 67 NSAID interactions with, 185, 193 pyrazolone-induced, 7, 99-104 anthranilic acid, relative safety, 18 analytical epidemiological anti-arthritic drugs, ~ antirheumatic studies, 101-3 drugs assessment of previous case anticoagulants, NSAID interactions with, reports, 100-1 183, 184 registry data, 101 antidiuretics, NSAID interactions with, report rate, 33 88 Alrheumat, generic name and manufac­ antihypertensives, NSAID interactions turer, 12 with, 185, 192, 196-7, 198-9, Alrheumun, generic name and manufac­ 204-10, see also beta blockers; turer, 12 diuretics albumin levels in the elderly, 7 antimalarials, conditional activity, 262 alclofenac antipyretics, conditional activity, 261 ARs with, 8 • antirheumatic (antiarthritic) drugs, 22- manufacturers, 8 3 aldosterone, 195, 196 patient drug preferences, 139, 140, allergic reactions, see hypersensitivity 142, 143 alminoprofen, trade mark names and slow acting, 22 manufacturers, 8 anti-ulcer drugs, 307-8 Alnovin, generic name and manufacturer, antrafenine, trade mark names and 10 manufacturers, 9 alpha-methine proton exchange, 222 Anturan, generic name and manufacturer, amfenac sodium 14 315 SIDE-EFFECTS OF ANTI-INFLAMMATORY DRUGS aplastic anaemia, ~ anaemia aurothiomalate, conditional activity, arachidonic acid cyclo-oxygenase, 233 261, 263 Archless, generic name and manufacturer, azapropazone 11 ARs, 19 Arlef, generic name and manufacturer, 11 number of reports of, 64 Arquel, generic name and manufacturer, interactions with other drugs, 182-3, 13 184 Arret, generic name and manufacturer, 9 sales, 71 arthritis and rheumatism trade mark names and manufacturers, 9 adjuvant-induced, rats with, 256-7 cytochrome levels in, 249, 250 NSAID gastrotoxicity in, 265, 266- Banamine, generic name and manufacturer, 7 11 collagen induced, 272-3 Benalgin, generic name and manufacturer, historical aspects of treatment, 5 9 osteo-, 292-3 bendroflumethiazide, indomethacin inter­ patient drug preferences, 139, 140 actions with, 205-6 perforated ulcers in patients with, benefit vs. risk, evaluating,S, 298 291 Benoral, generic name and manufacturer, psoriatic, patient drug preferences, 9 140, 142 benorylate, trade mark names and rheumatoid, ~ rheumatoid arthritis manufacturers, 9 seronegative, patient drug benoxaprofen preferences, 143 ARs, 7, 21 Arthrocine, generic name and manufac­ detection, 75-6 turer, 14 failure in detection, 120 Arthropan, generic name and manufac­ hepatic, 86 turer, 9 in the elderly, 7, 277-9 Artiflam, generic name and manufacturer, pharmacokinetic profile of, 277-9 15 prescription--event monitoring of, Artrinivo, generic name and manufac­ 112-23 passim turer, 12 trade mark names and manufacturers, 9 Artrivia, generic name and manufacturer, benzoic acid, structure--side-effects 12 relationship, 18 aryl acetic acids, derivatives and benzydamine hydrochloride, trade mark precursors of, 234 names and manufacturers, 9 aryl propionic acids, 2-, ~ Benzyrin, generic name and manufacturer, propionates 9 aseptic meningitis, 87 beta-blockers, NSAID interactions with, aseptic necrosis, 80 204-10 aspirin (acetyl salicylic acid) Biarison, generic name and manufacturer, activity, conditional, 262-3 14 agranulocytosis, association with, Biarson, generic name and manufacturer, 100 14 antiplatelet effect, 193 biases formulation, problems with, 7 affecting data interpretation from interactions with other drugs, 184, ADR reports, 105-10 185, 186, 188 in patient drug prefernce studies, sensitivity, 80 148 side-effects (general features), 127 bicarbonate, sodium, therapy, 6 in children with rheumatoid binding sites arthritis, 125-32 cyclo-oxygenase, drug interactions gastrointestinal, 311-13 at, 193 hepatic, 86 protein, ~ protein binding sites historical aspects, 6, 7 bleeding, ~ gastrointestinal tract incidence, 50, 135 blood dyscrasias, 19, 83-5 tolerance, 130 in the elderly, 157, 166 trade mark names and manufacturers, 8 incidence, 7, 65, 66 transacetylation potential, 235 report rate, 33 Aspirin, generic name and manufacturer, reports from Sweden, 62, 65, 66 8 blood pressure, drug interactions and, assays, anti-inflammatory activity, 229 196, 197, 199, 200, 204-10 association/dissociation constants, con­ passim ditional, 259 bowel disease, drug histories of asthma, 80 patients with, 304 in the elderly, 156-7 BPPC, manufacturers, 9 Atilan, generic name and manufacturer, Britai, generic name and manufacturer, 11 10 Atophan, generic name and manufacturer, Britain, ~ United Kingdom 9 bronchial constriction, 128 Atrobione, generic name and manufac­ Brufen turer, 9 generic name and manufacturer, 11 316 INDEX Brufen (continued) Clozic overdosage, 174-5 ARs, 8 Bufenid, generic name and manufacturer, generic name and manufacturer, 12 10 coenzyme A, esterification with, 221-2 bufexamic acid, trade mark names and cohort studies, 48 manufacturers, 9 collagen-induced arthritis, 272-3 Buss, Dr Carl, salicylate toxicity coma, 4 reports by, 5-6 Combec, generic name and manufacturer, 9 Butacote, generic name and manufacturer, Committee on Safety of Medicines, ADR 13 reports to/from, 300, 301 Butazolidin, generic name and manufac­ common side-effects, 76-8 turer, 13 concentration--effect relationships of Butazolidine, generic name and manufac­ the propionates, 223-4 turer, 13 conditional drug activity, 259-73 butazones, ARs to, 7, 19 factors determining, 269, 270 reported numbers of, 61, 64 Conforted, generic name and manufac­ butyl fenamate turer, 12 development, 20 Coslan, generic name and manufacturer, trade mark names and manufacturers, 9 13 BW755c, effect on prostaglandin syn­ Coxigon, 21 thesis, 20 generic name and manufacturer, 9 CS-600, manufacturers, 10 cutaneous reactions, ~ Skin captopril, NSAID interactions with, 196, cyclo-oxygenase 197 arachidonic acid-, inhibition, 233 carboxyl derivatives of NSAIDs, 233-4 binding sites, drug interactions at, carcinogen activation, 249 193 carcinogenicity of NSAIDs, 21 inhibitors, 237, 240, 309 cardiovascular system, see also heart cytochromes, 249-52, 254-6 ARs, 82-3 differences between, 243, 256 events with five NSAIDs, 116, 117, induction, 245 118 P-448, 243, 244, 245 protective effect of NSAIDs, 121 chemical activation by, 245, 246, carprofen, trade mark names and manufac­ 247, 248-9, 251 turers, 9 conditions increasing activities Cebutid, generic name and manufacturer, of, 251 11 roles, 248 central nervous system P-450, 243, 244, 245 ARs, 87, 144-5, 233 activity in rheumatoid patients, in the elderly, 157-8, 166 249-52 patients withdrawn from studies destruction, 255 due to, 128 isoenzymes of, 248 events with five NSAIDs, 116, 117, roles, 242, 250-1 118 children with rheumatoid arthritis, side-effects in, 125-35 Daital, generic name and manufacturer: chiral properties of the 'profens', ~ 10 propionates Danfenona, generic name and manufac­ chloroquine absorption, effect of ant­ turer, 11 acids on, 180, 181 data choline salicylate, trade mark names and interpretation from ADR reports, manufacturers, 9 biases affecting, 105-10 cimetidine, 292 patient, linking ADRs with other, 40 effect on cytochromes, 254-5 databases used in identifying ADRs, 48-9 cincophen in the elderly, 155-6 toxicity, 18 deaths, ~ fatalities trade mark names and manufacturers, 9 debrisoquine metabolism, genetic Cindomet, generic name and manufacturer, polymorphism, 248 9 Deflogix, generic name and manufacturer, cinmetacin, trade mark names and 14 manufacturers, 9 demographic data, importance, 41 Cinopal, generic name and manufacturer, denominators 10 chOice, incidence of ADR reports de­ clearance, enantioselective, 220-1, 223, pendent on, 67-8 281-2 factors affecting, 106 clidanac, trade mark names and manufac­ issues/concerns, 45-6 turers, 10 post-marketing, 44-5 Clinoril, generic name and manufacturer, pre-marketing, 41-2 14 depression, salicylate induced, 5 Clotam, generic name and manufacturer, dermatological ARs, ~ skin reactions 15 detection/identification of side- cloximate, manufacturers, 10 effects/ADRs, 75-6 317 SIDE-EFFECTS OF ANTI-INFLAMMATORY DRUGS detection/identification (oontiDued) data, importance, 41 in the elderly, 156-66 frequency, patient preferences, 149 detoxification of drugs, 243-5 historical aspects, 5 conpromised,
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