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(12) United States Patent (10) Patent No.: US 7,795,503 B2 Apuya Et Al

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(12) United States Patent (10) Patent No.: US 7,795,503 B2 Apuya Et Al US007795.503B2 (12) United States Patent (10) Patent No.: US 7,795,503 B2 Apuya et al. (45) Date of Patent: Sep. 14, 2010 (54) MODULATING PLANT ALKALOIDS 6,013,863 A 1/2000 Lundquist et al. 6,087,558 A 7/2000 Howard et al. (75) Inventors: Nestor Apuya, Culver City, CA (US); 6,093,874 A 7/2000 Jofuku et al. Steven Craig Bobzin, Malibu, CA (US); 6,136,320 A 10/2000 Arntzen et al. Joon-Hyun Park, Oak Park, CA (US) 6,235,975 B1 5, 2001 Harada et al. 6.255,562 B1 7/2001 Heyer et al. (73) Assignee: Ceres, Inc., Thousand Oaks, CA (US) 6,271,016 B1 8/2001 Anderson et al. 6,294,717 B1 9, 2001 Xie (*) Notice: Subject to any disclaimer, the term of this 6,303,341. B1 102001 Hiatt et al. patent is extended or adjusted under 35 6,326,527 B1 12/2001 Kirihara et al. U.S.C. 154(b) by 824 days. 6,329,567 B1 12/2001 Jofuku et al. 6,329,571 B1 12/2001 Hiei (21) Appl. 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