Letter to the Editor http://dx.doi.org/10.5021/ad.2015.27.5.637 Hypertrichosis and Hyperpigmentation in the Periocular Area Associated with Travoprost Treatment Hae-Eul Lee, Seul-Ki Lim, Myung Im, Chang-Deok Kim, Young-Joon Seo, Jeung-Hoon Lee, Young Lee Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea Dear Editor: of systemic adverse effects1,2. Among the three commer- Travoprost is one of the prostaglandin analogues (PGAs) cially available PGAs, bimatoprost and travoprost have re- used as powerful topical ocular hypotensive agents for the cently been shown to be more effective and with fewer treatment of open-angle glaucoma, and has a near absence adverse effects than latanoprost3. Commonly reported lo- Fig. 1. (A) At the time of the first visit, the primary complaints were hyperpigmentation and hypertricho- sis in the periocular area. Also note the increased length of the eyela- shes. (B) Six months after disconti- nuation of travoprost. Note the de- creased pigmentation in the perio- cular area. Also, the length and den- sity of both the hairs of the periocular area and the eyelashes are reduced. Received October 7, 2014, Revised November 28, 2014, Accepted for publication January 16, 2015 Corresponding author: Young Lee, Department of Dermatology, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea. Tel: 82-42-280-7706, Fax: 82-42-280-8459, E-mail:
[email protected] This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, pro- vided the original work is properly cited.