CORE Metadata, citation and similar papers at core.ac.uk Provided by Kyoto University Research Information Repository Title TRP channels as sensors of oxygen availability. Numata, Tomohiro; Ogawa, Nozomi; Takahashi, Nobuaki; Author(s) Mori, Yasuo Pflügers Archiv : European journal of physiology (2013), Citation 465(8): 1075-1085 Issue Date 2013-08 URL http://hdl.handle.net/2433/189741 The final publication is available at Springer via Right http://dx.doi.org/10.1007/s00424-013-1237-9 Type Journal Article Textversion author Kyoto University TRP channels as sensors of oxygen availability Tomohiro Numata1,2, Nozomi Ogawa1, Nobuaki Takahashi1,3 and Yasuo Mori1,2,4* 1Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan 2Laboratory of Environmental Systems Biology, Department of Technology and Ecology, Hall of Global Environmental Studies, Kyoto University, Kyoto, Japan 3Advanced Biomedical Engineering Research Unit, Kyoto University, Kyoto, Japan 4CREST, Japan Science and Technology Agency, Chiyoda-ku, Tokyo, Japan *Correspondence: Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, and Laboratory of Environmental Systems Biology, Department of Technology and Ecology, Hall of Global Environmental Studies, Kyoto University, Kyoto 615-8510, Japan E-mail:
[email protected] Tel: +81-75-383-2761 Fax: +81-75-383-2765 1 Abstract An ability to adapt to changes in oxygen availability is essential for survival in both prokaryotic and eukaryotic organisms. Recently, cation channels encoded by the transient receptor potential (trp) gene superfamily have been recognized as multimodal sensors of a wide variety of factors inside the cells and in the extracellular environment, and also as transducers of electrical and chemical signals mediated by ions such as Ca2+.