Covert Bacteriuria of Childhood a Clinical and Epidemiological Study D

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Covert Bacteriuria of Childhood a Clinical and Epidemiological Study D Arch Dis Child: first published as 10.1136/adc.48.1.8 on 1 January 1973. Downloaded from Archives of Disease in Childhood, 1973, 48, 8. Covert bacteriuria of childhood A clinical and epidemiological study D. C. L. SAVAGE, M. I. WILSON, M. McHARDY, D. A. E. DEWAR, and W. M. FEE From the Departments of Child Health, Bacteriology, and Radiology, University of Dundee, and the Child Health Services, City of Dundee Savage, D. C. L., Wilson, M. I., McHardy, M., Dewar, D. A. E., and Fee, W. M. (1973). Archives of Disease in Childhood, 48, 8. Covert bacteriuria of childhood: a clinical and epidemiological study. A 4-year screening pro- gramme for covert bacteriuria in Dundee primary schoolgirl entrants showed a prevalence of 1 6% and an annual incidence of 0 °9%. Among 109 children with bacteriuria, 70% had symptoms of lower urinary tract infection, 35% had vesico- ureteric reflux, and 23% radiological evidence of pyelonephritis. Both pyuria and a past history of urinary infection were related to radiological evidence of reflux or pyelonephritis. Covert bacteriuria was found more frequently in children from social classes IV and V; and their housing, home circumstances, and home care were worse than a control group, even when allowance was made for their social class differences. The children appeared generally healthy but were smaller than a control group. copyright. The data suggest that the great majority of these children are not seriously at risk and that there is at present not sufficient evidence to warrant prescriptive screening. Most publications on urinary tract infection higher in the younger Caucasian girls, and for this during childhood have been concerned with overt reason we decided in Dundee to screen primary infection, that is infection recognized by the symp- schoolgirl entrants (Savage et al., 1969). This toms it has caused. The clinical, laboratory, and study has continued and the present report details http://adc.bmj.com/ radiological findings in this group of children are the clinical, laboratory, bacteriological, and radio- well known, and the short and long-term prognoses logical findings. The epidemiological aspects are are now more clearly understood (Smellie and discussed and the case for prescriptive screening* Normand, 1968; MacGregor, 1970; Savage, 1971). for covert bacteriuria of childhood is appraised. Recently there has been interest in asympto- matic bacteriuria, that is significant bacteriuria Material and method detected during screening programmes. In these Study area. Dundee is an industrial city in Eastern on September 25, 2021 by guest. Protected surveys many of those found to have bacteriuria Scotland. The population of about 182,000 consists had symptoms referable to the lower urinary tract, largely of native-born Scots, and the main industries are and we believe the description asymptomatic to be jute and light engineering. inappropriate and have preferred the term 'covert'. Covert bacteriuria, therefore, is defined as signifi- Study population. From 1967 to 1970 the majority cant bacteriuria detected during a screening pro- of 5-year-old girls entering the Dundee Education gramme. Though adult populations, particularly Authority primary schools were screened for covert during pregnancy, have been extensively investi- bacteriuria (Table I). Those screened in 1967 were reported in a pilot study (Savage et al., 1969). During gated, there is little information about covert 1968 and 1969 almost all the schoolgirls had their bacteriuria during childhood. urine examined, but in 1970 a smaller number were In the only large survey during childhood examined primarily to collect more cases for a random- (Kunin, Deutscher, and Paquin, 1964) the rate of infection and radiological abnormalities was *Defined as a screening programme which has as its primary aim a direct contribution to the health of the individual (McKeown, Received 23 May 1972. 1968). 8 Arch Dis Child: first published as 10.1136/adc.48.1.8 on 1 January 1973. Downloaded from Covert bacteriuria of childhood 9 TABLE I Covert bacteriuria in Dundee schoolgirl entrants Prevalence 5-year-old Girls Incidence (1968 cohort re-examined) 1969 1443 99 3-3 8 0-6 1970 1323 99 31 16 12 Prevalence 13-year-old girls 1969 1455* 82 2-8 10 0-7 *Not all schools included. ized control trial of therapy. The incidence of a positive urine culture by this screening method had covert bacteriuria in the 1968 cohort was determined by further urine specimens examined by the plating-out rescreening them in 1969 and 1970. method used for colony counts in a diagnostic laboratory During 1969, 1455 13- to 14-year-old schoolgirls (Urquhart and Gould, 1965). Horse blood agar and copyright. (Table I) had their urine examined to determine the McConkey agar plates were seeded with a standard prevalence of bacteriuria in an older age group. loopful of urine ( 001* ml) from well-mixed but uncentri- fuged urine samples. The bacterial colony count was Presentation of programme to the community. expressed as the number of viable organisms per ml This has been detailed in a previous publication (Savage urine after the plates had been incubated at 37 °C et al., 1969). We have found no difficulty in obtaining overnight. the fullest co-operation from the schools, medical a programme Criteria for establishment of a case. 100,000 or personnel, and parents. Evidently http://adc.bmj.com/ intended to improve the health of the children in a more viable bacteria per ml urine on three consecutive community has found general acceptance. occasions was regarded as indicating significant bac- teriuria. Urine collections. Urine was collected at school Dip-slide culture. Specimens of urine from the either the school nurses or one of us (M.McH.). by final 300 schoolgirls aged 5 years were examined by the There was no previous cleansing of the extemal genitals Uricult* dip-slide method in parallel with the swab nor were was not a mid- the labia spread. The urine method used in this screening survey. Any specimen stream specimen and was collected in a disposable i.e. or semi- been in the that gave a positive result, confluent on September 25, 2021 by guest. Protected sterile aluminium bowl which had placed confluent growth, with either the dip-slide or swab child's pot. The urine was then poured into a disposable was examined by Uricult was sealed and culture, or both, again (1) sterile polythene container which (2) the swab method of plating out, (3) the in an insulated standard portable blood trans- dip-slide, placed standard loop method of plating out, and (4) pour fusion box maintained at between 4 to 6 °C by a water- filled container which had been frozen ovemight. plate culture. The urine was transported back to the laboratory within Urological investigation. Children whose first 3 hours of collection. urine specimen was positive had 2 further midstream specimens of urine collected under the supervision of a Bacteriological methods. On arrival at the nurse. Initially if these contained a significant number laboratory the specimens of urine were placed in a of bacteria the child was admitted for investigation of refrigerator maintained at 6 °C and examined within 1 renal finction. Over the last 2 years, however, the hour. The urine was cultured by the swab method children have been investigated as outpatients. described by Bradley, Crowley, and Darrell (1967). The plasma urea, creatinine, electrolytes, and the A pure, or nearly pure, and confluent, or semiconfluent, growth was indicative of bacteriuria. Any child with *Bristol Laboratories, Stamford House, Langley, England. Arch Dis Child: first published as 10.1136/adc.48.1.8 on 1 January 1973. Downloaded from 10 Savage, Wilson, McHardy, Dewar, and Fee serum calcium, phosphate, alkaline phosphatase, and gramme. One child's parents refused to allow her proteins were determined, and the ESR, haemoglobin, ot attend the clinic and she has not been included in and blood film were routinely examined. The children the data except as one of the total with covert had an intravenous pyelogram, micturating cystogram, bacteriuria. The parents of 3 children refused a chest x-ray, and a left wrist x-ray for determination of radiological investigation in their child and 2 bone age. Intravenous pyelography (IVP) included tomography cystograms were not completed for technical ofthe kidneys in those children in whom the renal cortical reasons. Therefore 106 children are detailed with outline could not be clearly defined on the routine the result of their intravenous pyelogram but only films. During micturating cystography there was no 104 children had a micturating cystogram completed screening and three films only were taken. The first satisfactorily. followed bladder filling, the second was taken after 20 Further data on the 10 girls aged 13 years are minutes' delay with push-back into the catheter which detailed separately. was connected to a reservoir, and the third was a mictura- ting film. Children with significant urological abnor- malities were examined by cystoscopy. Primary schoolgirl entrants History and symptoms in children with Results covert bacteriuria. There was a past history of urinary infection in 20% of the children. Urinary Participation. During 1968 and 1969, 96% infection had been diagnosed in 1 child during of the Dundee primary schoolgirl entrants had infancy, in 8 in their third year, in 5 in their fourth their urine examined. 99 % of the available 1968 year, and in the remainder (8) in the year before cohort of schoolgirls had their urine re-examined primary school entry. None of these children was in 1969 and again in 1970 (Table I). regarded by her parents or general practitioners as having a urinary infection at the time of screening Screening level for significant bacteriuria. nor were any on therapy. Those children with semiconfluent or confluent In over a quarter of the children there was a growth had a repeat urine examination, and with family history of urinary infection.
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