www.oncotarget.com Oncotarget, 2019, Vol. 10, (No. 39), pp: 3939-3951 Research Paper Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas Richard Glenn C. Delacruz1, Imelda T. Sandoval1, Kyle Chang2,7, Braden N. Miller1,8, Laura Reyes-Uribe2, Ester Borras2, Patrick M. Lynch3,6, Melissa W. Taggart4, Ernest T. Hawk2, Eduardo Vilar2,5,6,7,* and David A. Jones1,* 1Functional and Chemical Genomics, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA 2Department of Clinical Cancer Prevention, The University of Texas UTHealth MD Anderson Cancer Center, Houston, TX, USA 3Department of Gastroenterology, Hepatology and Nutrition, The University of Texas UTHealth MD Anderson Cancer Center, Houston, TX, USA 4Department of Pathology, The University of Texas UTHealth MD Anderson Cancer Center, Houston, TX, USA 5Department of GI Medical Oncology, The University of Texas UTHealth MD Anderson Cancer Center, Houston, TX, USA 6Clinical Genetics Program, The University of Texas UTHealth MD Anderson Cancer Center, Houston, TX, USA 7Graduate School of Biomedical Sciences, The University of Texas UTHealth MD Anderson Cancer Center, Houston, TX, USA 8College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA *These authors contributed equally to this work Correspondence to: David A. Jones, email:
[email protected] Eduardo Vilar, email:
[email protected] Keywords: familial adenomatous polyposis; colon cancer; APC; CNOT3; CtBP1 Received: April 16, 2019 Accepted: May 20, 2019 Published: June 11, 2019 Copyright: Delacruz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.