Interrupting Prolonged Sitting in Type 2 Diabetes: Nocturnal Persistence of Improved Glycaemic Control
Diabetologia (2017) 60:499–507 DOI 10.1007/s00125-016-4169-z ARTICLE Interrupting prolonged sitting in type 2 diabetes: nocturnal persistence of improved glycaemic control Paddy C. Dempsey1,2 & Jennifer M. Blankenship3 & Robyn N. Larsen1 & Julian W. Sacre1 & Parneet Sethi1 & Nora E. Straznicky1 & Neale D. Cohen1 & Ester Cerin1,4,5 & Gavin W. Lambert1,2 & Neville Owen1,2,6,7 & Bronwyn A. Kingwell1,2 & David W. Dunstan1,2,8,9,10,11 Received: 25 August 2016 /Accepted: 4 November 2016 /Published online: 9 December 2016 # Springer-Verlag Berlin Heidelberg 2016 Abstract every 30 min. In the present study, continuous glucose mon- Aims/hypothesis We aimed to examine the effect of itoring was performed for 22 h, encompassing the 7 h labora- interrupting 7 h prolonged sitting with brief bouts of walking tory trial, the evening free-living period after leaving the lab- or resistance activities on 22 h glucose homeostasis (including oratory and sleeping periods. Meals and meal times were nocturnal-to-following morning hyperglycaemia) in adults standardised across conditions for all participants. with type 2 diabetes. Results Compared with SIT, both LW and SRA reduced 22 h Methods This study is an extension of a previously published glucose [SIT: 11.6 ± 0.3 mmol/l, LW: 8.9 ± 0.3 mmol/l, SRA: randomised crossover trial, which included 24 inactive 8.7 ± 0.3 mmol/l; p < 0.001] and nocturnal mean glucose con- overweight/obese adults with type 2 diabetes (14 men; 62 centrations [SIT: 10.6 ± 0.4 mmol/l, LW: 8.1 ± 0.4 mmol/l, ± 6 years) who completed three 7 h laboratory conditions, SRA: 8.3 ± 0.4 mmol/l; p < 0.001].
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