Asymmetric Synthesis Using a Camphene-Derived Chiral Auxiliary
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Aldrich Raman
Aldrich Raman Library Listing – 14,033 spectra This library represents the most comprehensive collection of FT-Raman spectral references available. It contains many common chemicals found in the Aldrich Handbook of Fine Chemicals. To create the Aldrich Raman Condensed Phase Library, 14,033 compounds found in the Aldrich Collection of FT-IR Spectra Edition II Library were excited with an Nd:YVO4 laser (1064 nm) using laser powers between 400 - 600 mW, measured at the sample. A Thermo FT-Raman spectrometer (with a Ge detector) was used to collect the Raman spectra. The spectra were saved in Raman Shift format. Aldrich Raman Index Compound Name Index Compound Name 4803 ((1R)-(ENDO,ANTI))-(+)-3- 4246 (+)-3-ISOPROPYL-7A- BROMOCAMPHOR-8- SULFONIC METHYLTETRAHYDRO- ACID, AMMONIUM SALT PYRROLO(2,1-B)OXAZOL-5(6H)- 2207 ((1R)-ENDO)-(+)-3- ONE, BROMOCAMPHOR, 98% 12568 (+)-4-CHOLESTEN-3-ONE, 98% 4804 ((1S)-(ENDO,ANTI))-(-)-3- 3774 (+)-5,6-O-CYCLOHEXYLIDENE-L- BROMOCAMPHOR-8- SULFONIC ASCORBIC ACID, 98% ACID, AMMONIUM SALT 11632 (+)-5-BROMO-2'-DEOXYURIDINE, 2208 ((1S)-ENDO)-(-)-3- 97% BROMOCAMPHOR, 98% 11634 (+)-5-FLUORODEOXYURIDINE, 769 ((1S)-ENDO)-(-)-BORNEOL, 99% 98+% 13454 ((2S,3S)-(+)- 11633 (+)-5-IODO-2'-DEOXYURIDINE, 98% BIS(DIPHENYLPHOSPHINO)- 4228 (+)-6-AMINOPENICILLANIC ACID, BUTANE)(N3-ALLYL)PD(II) CL04, 96% 97 8167 (+)-6-METHOXY-ALPHA-METHYL- 10297 ((3- 2- NAPHTHALENEACETIC ACID, DIMETHYLAMINO)PROPYL)TRIPH 98% ENYL- PHOSPHONIUM BROMIDE, 12586 (+)-ANDROSTA-1,4-DIENE-3,17- 99% DIONE, 98% 13458 ((R)-(+)-2,2'- 963 (+)-ARABINOGALACTAN BIS(DIPHENYLPHOSPHINO)-1,1'- -
C-Metalated Nitriles: Diastereoselective Alkylations and Arylations
Duquesne University Duquesne Scholarship Collection Electronic Theses and Dissertations Fall 12-20-2019 C-Metalated Nitriles: Diastereoselective Alkylations and Arylations Robert John Mycka Duquesne University Follow this and additional works at: https://dsc.duq.edu/etd Part of the Organic Chemistry Commons Recommended Citation Mycka, R. J. (2019). C-Metalated Nitriles: Diastereoselective Alkylations and Arylations (Doctoral dissertation, Duquesne University). Retrieved from https://dsc.duq.edu/etd/1851 This Immediate Access is brought to you for free and open access by Duquesne Scholarship Collection. It has been accepted for inclusion in Electronic Theses and Dissertations by an authorized administrator of Duquesne Scholarship Collection. C-METALATED NITRILES: DIASTEREOSELECTIVE ALKYLATIONS AND ARYLATIONS A Dissertation Submitted to the Bayer School of Natural and Environmental Sciences Duquesne University In partial fulfillment of the requirements for the degree of Doctor of Philosophy By Robert J. Mycka December 2019 Copyright by Robert J. Mycka 2019 C-METALATED NITRILES: DIASTEREOSELECTIVE ALKYLATIONS AND ARYLATIONS By Robert J. Mycka Approved November 13, 2019 ________________________________ ________________________________ Dr. Bruce D. Beaver Dr. Jeffrey D. Evanseck Professor of Chemistry and Biochemistry Professor of Chemistry and Biochemistry (Committee Chair) (Committee Member) ________________________________ ________________________________ Dr. Shahed U. M. Khan Dr. Patrick T. Flaherty Associate Professor of Chemistry and -
Chemical Resistance of Plastics
(c) Bürkle GmbH 2010 Important Important information The tables “Chemical resistance of plastics”, “Plastics and their properties” and “Viscosity of liquids" as well as the information about chemical resistance given in the particular product descriptions have been drawn up based on information provided by various raw material manufacturers. These values are based solely on laboratory tests with raw materials. Plastic components produced from these raw materials are frequently subject to influences that cannot be recognized in laboratory tests (temperature, pressure, material stress, effects of chemicals, construction features, etc.). For this reason the values given are only to be regarded as being guidelines. In critical cases it is essential that a test is carried out first. No legal claims can be derived from this information; nor do we accept any liability for it. A knowledge of the chemical and mechanical Copyright This table has been published and updated by Bürkle GmbH, D-79415 Bad Bellingen as a work of reference. This Copyright clause must not be removed. The table may be freely passed on and copied, provided that Extensions, additions and translations If your own experiences with materials and media could be used to extend this table then we would be pleased to receive any additional information. Please send an E-Mail to [email protected]. We would also like to receive translations into other languages. Please visit our website at http://www.buerkle.de from time to Thanks Our special thanks to Franz Kass ([email protected]), who has completed and extended these lists with great enthusiasm and his excellent specialist knowledge. -
Development of Palladium-Catalyzed Decarboxylative Allylation of Electron-Deficient Sulfones: Method Development and Mechanistic Studies
Development of Palladium-Catalyzed Decarboxylative Allylation of Electron-Deficient Sulfones: Method Development and Mechanistic Studies by Monica Anne Gill A thesis submitted to the Faculty of Graduate and Postdoctoral Affairs in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Chemistry Carleton University Ottawa, Ontario © 2015, Monica Anne Gill Abstract Palladium-catalyzed decarboxylative allylation is a powerful method of carbon-carbon bond construction. This methodology relies on an electron- withdrawing group to promote the reaction. The use of sulfones in decarboxylative allylation has been explored using the trifluoromethylsulfonyl (triflyl) group, as well as the bis(3,5-trifluoromethyl)phenylsulfonyl (BTMP) group. These substrates are highly reactive at room temperature (triflyl) and 50 oC (BTMP sulfones). A detailed mechanistic study using deuterium-labelled substrates was performed to understand the origin of the protonation side-product. It was proposed that a β- hydride elimination from the η1 allyl on palladium could generate a palladium hydride intermediate along with an allene. Although small amounts of deuterium incorporation were observed in the protonated products, the proposed mechanism could not be the major pathway. Using isotopically labelled ligand, however, all protonation was supressed. This suggests that the origin of the proton is actually from the ligand and that kinetic isotope effects may be responsible for inhibiting the protonation pathway with labelled ligand. ii Acknowledgments I would like to thank Dr. Jeff Manthorpe for giving me the chance to pursue my PhD in his lab. I always appreciated Jeff’s enthusiasm for organic chemistry as well as his vast knowledge of the subject. -
Synthesis of Polycyclic Natural Products Tuan Hoang Nguyen Iowa State University
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 2003 Synthesis of polycyclic natural products Tuan Hoang Nguyen Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Medicinal and Pharmaceutical Chemistry Commons, Medicinal Chemistry and Pharmaceutics Commons, Medicinal-Pharmaceutical Chemistry Commons, and the Organic Chemistry Commons Recommended Citation Nguyen, Tuan Hoang, "Synthesis of polycyclic natural products " (2003). Retrospective Theses and Dissertations. 1452. https://lib.dr.iastate.edu/rtd/1452 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. Synthesis of polycyclic natural products by Tuan Hoang Nguyen A dissertation submitted to the graduate faculty in partial fulfillment of the requirements for the degree of DOCTOR. OF PHILOSOPHY Major: Organic Chemistry Program of Study Committee: George A. Kraus (Major Professor) Richard C. Larock Valerie V. Sheares-Ashby Jacob W. Petrich Earl G. Hammond Iowa State University Ames, Iowa 2003 UMI Number: 3105095 UMI UMI Microform 3105095 Copyright 2003 by ProQuest Information and Learning Company. All rights reserved. This microform edition is protected against unauthorized copying under Title 17, United States Code. ProQuest Information and Learning Company 300 North Zeeb Road P.O. Box 1346 Ann Arbor, Ml 48106-1346 ii Graduate College Iowa State University This is to certify that the doctoral dissertation of Tuan Hoang Nguyen has met the requirements of Iowa State University Signature was redacted for privacy. -
ABSTRACT ZOU, YAN. Applications of [2+2+2] Cyclotrimerization
ABSTRACT ZOU, YAN. Applications of [2+2+2] Cyclotrimerization Reactions and Light-Cleavable Groups in the Generation of Biologically Active Molecules. (Under the direction of Dr. Alexander Deiters). [2+2+2] Cyclotrimerization reactions are a versatile tool for constructing the poly- substituted carbo- and hetero- cyclic ring systems. A number of transition metal catalysts, such as Co, Ru, Rh, Ni and Pd complexes, have been applied. However, there are still regio- and chemo- selectivity issues present in [2+2+2] cyclotrimerization reactions, and only few applications of cyclotrimerization reactions in the synthesis of natural products have been reported. We aimed to develop cyclotrimerization reactions for the assembly of benzene and pyridine core structures found in natural products and for applications in the synthesis of fluorophores. Microwave irradiation, a more recent method used to assist organic reactions, was employed in various cyclotrimerization reactions. In order to obtain greater control over the chemoselectivity of these reactions, we developed a solid-supported method of cyclotrimerization reactions through the immobilization of an alkyne or diyne onto a polymer backbone. This methodology was applied to the assembly of poly-substituted pyridines. Furthermore, the microwave mediated cyclotrimerization methodology was utilized to synthesize various anthracene and azaanthracene fluorophores. Additionally, a cyclotrimerization reaction was used in key steps of the total synthesis of the natural products cryptoacetalide and the pyridine core of cyclothiazomycin. Currently, the cyclotrimerization reaction is being utilized in the ongoing synthesis of petrosasponglide L. Photolabile protecting groups (caging groups) have attracted considerable attention in the field of chemical biology. These caging groups are installed on biomolecules of interest to control their function with light. -
Studies in Meroterpenoid Synthesis
Studies in Meroterpenoid Synthesis A thesis presented by Jonathan W. Lockner to The Scripps Research Institute Graduate Program in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the subject of Chemistry for The Scripps Research Institute La Jolla, California November 2011 1 UMI Number: 3507067 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent on the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. UMI 3507067 Copyright 2012 by ProQuest LLC. All rights reserved. This edition of the work is protected against unauthorized copying under Title 17, United States Code. ProQuest LLC. 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, MI 48106 - 1346 © 2011 by Jonathan W. Lockner All rights reserved. 2 Thesis Acceptance Form 3 Acknowledgements As a high school student in Plainfield, Illinois, I had the benefit of learning chemistry from Mr. Hill. He supplemented my experience with “Semi-Micro Qualitative Analysis” – allowing me to perform simple chemistry experiments after school. As an undergraduate at the University of Illinois at Urbana-Champaign, I had the opportunity to carry out synthetic organic chemistry research in the laboratory of Professor Robert M. Coates. I am indebted to him, as well as Dr. Chad Davis (then a graduate student and my mentor), for their influence in setting me on the path of scientific research. My first employment was at Pharmacia in Kalamazoo, Michigan. -
Acutely Toxic Chemicals Chemical Class Standard Operating Procedure
Acutely Toxic Chemicals Chemical Class Standard Operating Procedure Acutely Toxic Chemicals (ATCs) H300 H301 H304 H310 H311 H330 H331 H370 H372 Areas with blue text indicate that information must be provided or modified by researcher prior to the SOP approval. This SOP is not a substitute for hands-on training. Print a copy and insert into your laboratory SOP binder. Department: Chemistry Date SOP was written: Monday, October 24, 2016 Date SOP was approved by PI/lab supervisor: Name: R. Sarpong Principal Investigator: Signature: ______________________________ Name: Melissa Hardy/Justin Jurczyk Internal Lab Safety Coordinator or Lab Manager: Lab Phone: 406-696-1225/412-728-1952 Office Phone: 510-642-6312 Name: Melissa Hardy/Justin Jurczyk Emergency Contact: Lab Phone: 406-696-1225/412-728-1952 Latimer Hall Location(s) covered by this SOP: 831,832,834,836,837,838,839,842,844,847,849 1. Purpose This SOP covers the precautions and safe handling procedures for the use of Acutely Toxic Chemicals (ATCs). For a list of ATCs covered by this SOP and their use(s), see “List of Chemicals”. Procedures described in Section 12 apply to all materials covered in this SOP. If you have questions concerning the applicability of any recommendation or requirement listed in this procedure, contact the Principal Investigator/Laboratory Supervisor or the campus Chemical Hygiene Officer at [email protected]. Rev. Date: 09Sept2016 1 Acutely Toxic Chemicals Chemical Class Standard Operating Procedure 2. Acutely Toxic Chemicals Information Acute toxicity refers to those adverse effects occurring following oral or dermal administration of a single dose of a substance, or multiple doses within 24 hours, or an inhalation exposure of 4 hours as defined by the Globally Harmonized System (GHS). -
Acetic Acid Toxic
Chemical Waste Name or Mixtures: Listed Characteristic Additional Info Disposal Notes (-)-B- bromodiisopropinocampheyl (-)-DIP-Bromide Non Hazardous None liquid: sanitary sewer/ solid: trash borane (-)-B- chlorodiisopropinocampheylb (-)-DIP-Chloride Non Hazardous None liquid: sanitary sewer/ solid: trash orane [(-)-2-(2,4,55,7-tetranitro-9- fluorenyodeneaminooxy)pro (-)-TAPA Non Hazardous None liquid: sanitary sewer/ solid: trash pionic acid] (+)-B- bromodiisopropinocampheyl (+)-DIP-Bromide Non Hazardous None liquid: sanitary sewer/ solid: trash borane (+)-B- chlorodiisopropinocampheylb (+)-DIP-Chloride Non Hazardous None liquid: sanitary sewer/ solid: trash orane [(+)-2-(2,4,55,7-tetranitro-9- fluorenylideneaminooxy)prop (+)-TAPA Non Hazardous None liquid: sanitary sewer/ solid: trash ionic acid] (2,4,5-Trichlorophenoxy) Acetic Acid Toxic None EHS NA (2,4-Dichlorophenoxy) Acetic Acid Toxic None EHS NA trans-8,trans-10-dodecadien- (E,E)-8,10-DDDA Non Hazardous None liquid: sanitary sewer/ solid: trash 1-ol trans-8,trans-10-dodecadien- (E,E)-8,10-DDDOL Non Hazardous None liquid: sanitary sewer/ solid: trash 1-yl acetate trans-7,cis-9-dodecadien-yl (E,Z)-7,9-DDDA Non Hazardous None liquid: sanitary sewer/ solid: trash acetate (Hydroxypropyl)methyl Cellulose Non Hazardous None liquid: sanitary sewer/ solid: trash NA ammonium phosphate (NH4)2HPO4 Non Hazardous None liquid: sanitary sewer/ solid: trash (dibasic) (NH4)2SO4 Non Hazardous None liquid: sanitary sewer/ solid: trash ammonium sulfate ammonium phosphate (NH4)3PO4 Non Hazardous None -
The War Gases
THE WAR GASES CHEMISTRY AND ANALYSIS BY DR. MARIO SARTORI Chemist of the Italian Chemical Warfare Service Preface by PROFESSOR G. BARGELLINI of Rome University Translated from the Second Enlarged Italian Edition by L. W. MARRISON, B.Sc., A.I.C. With 20 Figures and 15 Tables NEW YORK D. VAN NOSTRAND CO., INC. 250 FOURTH AVENUE 1939 PREFACE TO THE FIRST ITALIAN EDITION THE world conflict of 1914-18 opened a new field of study in the Chemistry of War : that of the war gases. Thus the Chemistry of War, which had for its cradle the chemical laboratory in Turin where Ascanio Sobrero discovered nitroglycerine and which for 60 years was confined to the study of explosives, underwent a new development and a new orientation when substances which had an offensive action on the human and animal organism were first used on the field of battle. Then commenced the study of war gases which has become one of the most complex and important departments of chemistry. Our present knowledge of most of these asphyxiating gases is very superficial and even inexact, which is the reason that while some merit the importance given to them, others tend to be overvalued. Books are therefore necessary to give information as to what has been published of the constitution, the methods of preparation and the properties of these substances. While many German, American and Russian treatises elucidate this subject, which is of such great and present interest, in a wide and complete manner, few publications exist on the subject in the Italian language. -
Flammable Liquids and Solids Chemical Class Standard Operating Procedure
Flammable Liquids and Solids Chemical Class Standard Operating Procedure Flammable Liquids and Solids H224 H225 H226 H227 H228 Areas with blue text indicate that information must be provided or modified by researcher prior to the SOP approval. This SOP is not a substitute for hands-on training. Print a copy and insert into your laboratory SOP binder. Department: Chemistry Date SOP was written: Monday, October 24, 2016 Date SOP was approved by PI/lab supervisor: Name: R. Sarpong Principal Investigator: Signature: ______________________________ Name: Melissa Hardy/Justin Jurczyk Internal Lab Safety Coordinator or Lab Manager: Lab Phone: 406-696-1225/412-728-1952 Office Phone: 510-642-6312 Name: Melissa Hardy/Justin Jurczyk Emergency Contact: Lab Phone: 406-696-1225/412-728-1952 Latimer Hall Location(s) covered by this SOP: 831,832,834,836,837,838,839,842,844,847,849 1. Purpose This SOP covers the precautions and safe handling procedures for the use of Flammable Liquids and Solids. For a list of Flammable Liquids and Solids covered by this SOP and their use(s), see “List of Chemicals”. Procedures described in Section 12 apply to all materials covered in this SOP. If you have questions concerning the applicability of any recommendation or requirement listed in this procedure, contact the Principal Investigator/Laboratory Supervisor or the campus Chemical Hygiene Officer at [email protected]. Rev. Date: 09Sept2016 1 Flammable Liquids and Solids Chemical Class Standard Operating Procedure 2. Physical & Chemical Properties/Definition of Chemical Group Flammable liquid means a liquid having a flash point1 of not more than 199.4 °F (93 °C). -
Royal Decree on Control of Export Armaments and War Materials out of the Kingdom (No
ROYAL DECREE ON CONTROL OF EXPORT ARMAMENTS AND WAR MATERIALS OUT OF THE KINGDOM (NO. 2) B.E. 2552 _____________ BHUMIBOL ADULYADEJ, REX; Given on the 1st of June B.E. 2552: Being the 64th Year of the Present Reign. His Majesty King Bhumibol Adulyadej is graciously pleased to proclaim that: Whereas it is expedient to amend the law on control of export armaments and war materials out of the Kingdom; By virtue of section 187 of the Constitution of the Kingdom of Thailand and section 3 and section 4 of the Control of Armament Act B.E. 2530 contains certain provisions in relation to the restriction of rights and liberties of a person, in respect of which section 29 in conjunction with section 41 of the Constitution of the Kingdom of Thailand so permit by the virtue of law; the Minister of Defense upon the approval of the Council of Ministers hereby issues the Notification as follows: Section 1. This Royal Decree is called the “Royal Decree on Control of Export of Armaments and War Materials out of the Kingdom (No. 2) B.E. 2552”. Section 2. This Act shall come into force as from the day following the date of its publication in the Government Gazette. Section 3. The annex of the Royal Decree on Control of Export of Armaments and War Materials out of the Kingdom B.E. 2535 shall be repealed and replaced by the annex of this Royal Decree. Countersigned by Abhisit Vejjajiva Prime Minister 2 Annex of the Royal Decree on Control of Export of Armaments and War Materials out of the Kingdom (No.