Supplemental Texts
Text S1. Details of PrediXcan’s approach of estimating cis-eQTL effect sizes
PrediXcan TWAS method [1] employs Elastic-Net penalized regression method [2] to estimate cis-eQTL effect sizes � from Equation (1) in the main text. Basically, the Elastic-Net method assumes a combined LASSO (� ) [3] and Ridge (� ) [4] penalty and estimate � by the following equation