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Open main menu Wikipedia Search Charles Scott Sherrington Language Download PDF Watch Edit Sir Charles Scott Sherrington OM PRS FRCP FRCS[1][10] (27 November 1857 – 4 March 1952) was an English neurophysiologist, histologist, bacteriologist, and a pathologist, Nobel laureate and president of the Royal Society in the early 1920s. He received the in or with , 1st Baron Adrian, in 1932 for their work on the functions of neurons.[11][12] Prior to the work of Sherrington and Adrian, it was widely accepted that reflexes occurred as isolated activity within a reflex arc. Sherrington received the prize for showing that reflexes require integrated activation and demonstrated reciprocal innervation of muscles (Sherrington's law).[13][14] Through his seminal 1906 publication, The Integrative Action of the Nervous System,[15] he had effectively laid to rest the theory that the nervous system, including the brain, can be understood as a single interlinking network. His alternative explanation of synaptic communication between neurons helped shape our understanding of the central nervous system. Sir Charles Scott Sherrington OM GBE PRS FRCP FRCS Charles Scott Sherrington2.jpg Born 27 November 1857 Islington, Middlesex, England, United Kingdom Died 4 March 1952 (aged 94) Eastbourne, Sussex, England, United Kingdom Citizenship British Alma mater Ipswich School Royal College of Surgeons of England University of Awards FRS (1893)[1] (1905) (1927) Nobel Prize in Physiology or Medicine (1932) Scientific career Fields Physiology Histology Neurology Bacteriology Academic advisors Michael Foster John Newport Langley Doctoral students John Farquhar Fulton John Carew Eccles Alfred Fröhlich[2] Influences Johannes Müller Thomas Ashe Jean Fernel Thomas Browne[3] Influenced Sir John Eccles[4][5] [6] E.M. Tansey[7] [8] Wilder Penfield[9] Biography Edit Early years and education Edit Official biographies claim Charles Scott Sherrington was born in Islington, London, England, on 27 November 1857 and that he was the son of James Norton Sherrington, a country doctor, and his wife Anne Thurtell.[16] However James Norton Sherrington was an ironmonger and artist's colourman in Great Yarmouth, not a doctor, and died in Yarmouth in 1848, nearly 9 years before Charles was born.[17][18] In the 1861 census, Charles is recorded as Charles Scott (boarder, 4, born India) with Anne Sherrington (widow) as the head and Caleb Rose (visitor, married, surgeon).[19] He was brought up in this household with Caleb recorded as head in 1871,[20] although Ann and Caleb did not marry until after the death of his wife in 1880.[21] The relationship between Charles and his childhood family is unknown. During the 1860s the whole family moved to Anglesea Road, Ipswich, reputedly because London exacerbated Caleb Rose's tendency to asthma.[22] Sherrington's origins have been discussed in several published sources: Chris Moss and Susan Hunter, in the Journal of Medical Biography of January 2018, presented an article discussing the potential origins of Charles Sherrington, i.e. whether he was born in India of unknown parents, or was the illegitimate child of Caleb Rose and Anne Sherrington.[23][24] Erling Norrby, Ph.D, in Nobel Prizes and Notable Discoveries (2016) observed: "His family origin apparently is not properly given in his official biography. Considering that motherhood is a matter of fact and fatherhood a matter of opinion, it can be noted that his father was not James Norton Sherrington, from whom his family name was derived. Charles was born 9 years after the death of his presumed father. Instead Charles and his two brothers were the illegitimate sons of Caleb Rose, a highly regarded Ipswich surgeon."[25] In Ipswich Town: A History, lakhasly.com © ﺗﻢ ﺗﻠﺨﻴﺺ اﻟﻨﺺ ﺑﻮاﺳﻄﺔ ﻣﻮﻗﻊ ﻟﺨﺼﻠ Susan Gardiner writes: "George and William Sherrington, along with their older brother, Charles, were almost certainly the illegitimate sons of Anne Brookes, née Thurtell and Caleb Rose, a leading surgeon from Ipswich, with whom she was living in College Road, Islington at the time that all three boys were born. No father was named in the baptism register of St James' Church, Clerkenwell, and there is no official record of the registration of any of their births. It was claimed they were the sons of a country doctor, James Norton Sherrington. However, it was with Caleb Rose that Anne and the three Sherrington boys moved to Anglesea Road, Ipswich in 1860 and the couple were married in 1880 after Caleb's first wife had died."[26] Of James Norton Sherrington, Judith Swazey, in Reflexes and Motor Integration: Sherrington's Concept of Integrative Action (1969), quotes Charles Scott Sherrington's son, Carr Sherrington: "James N. Sherrington was always called Mr. and I have no knowledge that he was a Dr. either in law or in medicine... [He] was mainly interested in art and was a personal friend of J. B. Crone and other painters."[27] Caleb Rose was noteworthy as both a classical scholar and an archaeologist. At the family's Edgehill House in Ipswich one could find a fine selection of paintings, books, and geological specimens.[1][28] Through Rose's interest in the Norwich School of Painters, Sherrington gained a love of art.[29] Intellectuals frequented the house regularly. It was this environment that fostered Sherrington's academic sense of wonder. Even before matriculation, the young Sherrington had read Johannes Müller's Elements of Physiology. The book was given to him by Caleb Rose. Sherrington entered Ipswich School in 1871.[1] Thomas Ashe, a famous English poet, worked at the school. Ashe served as an inspiration to Sherrington, the former instilling a love of classics and a desire to travel in the latter. Rose had pushed Sherrington towards medicine. Sherrington first began to study with the Royal College of Surgeons of England. He also sought to study at Cambridge, but a bank failure had devastated the family's finances. Sherrington elected to enroll at St Thomas' Hospital in September 1876 as a "perpetual pupil".[1] He did so in order to allow his two younger brothers to do so ahead of him. The two studied law there. Medical studies at St. Thomas's Hospital were intertwined with studies at Gonville and Caius College, Cambridge.[28] Physiology was Sherrington's chosen major at Cambridge. There, he studied under the "father of British physiology," Sir Michael Foster.[30] Sherrington played football for his grammar school, and for Ipswich Town Football Club; he played rugby for St. Thomas's, was on the rowing team at .[28][31] During June 1875, Sherrington passed his preliminary examination in general education at the Royal College of Surgeons of England (RCS). This preliminary exam was required for Fellowship, and also exempted him from a similar exam for the Membership. In April 1878, he passed his Primary Examination for the Membership of the RCS, and twelve months later the Primary for Fellowship. In October 1879, Sherrington entered Cambridge as a non-collegiate student.[32] The following year he entered Gonville and Caius College. Sherrington was a first-rate student. In June 1881, he took Part I in the Natural Sciences Tripos (NST) and was awarded a Starred first in physiology; there were nine candidates in all (eight men, one woman), of whom five gained First- class honours (Firsts); in June 1883, in Part II of the NST, he also gained a First, alongside William Bateson.[33] Walter Holbrook Gaskell, one of Sherrington's tutors, informed him in November 1881 that he had earned the highest marks for his year in botany, human anatomy, and physiology; second in zoology; and highest overall.[28] John Newport Langley was Sherrington's other tutor. The two were lakhasly.com © ﺗﻢ ﺗﻠﺨﻴﺺ اﻟﻨﺺ ﺑﻮاﺳﻄﺔ ﻣﻮﻗﻊ ﻟﺨﺼﻠ interested in how anatomical structure is expressed in physiological function.[30] Sherrington earned his Membership of the Royal College of Surgeons on 4 August 1884. In 1885, he obtained a First Class in the Natural Science Tripos with the mark of distinction. In the same year, Sherrington earned the degree of M.B., Bachelor of Medicine and Surgery from Cambridge. In 1886, Sherrington added the title of L.R.C.P., Licentiate of the Royal College of Physicians.[1] Seventh International Medical Congress Edit Charles Scott Sherrington The conference was held in London in 1881. It was at this conference that Sherrington began his work in neurological research. At the conference controversy broke out. Friedrich Goltz of Strasbourg argued that localized function in the cortex did not exist. Goltz came to this conclusion after observing dogs who had parts of their brains removed. David Ferrier, who became a hero of Sherrington's, disagreed. Ferrier maintained that there was localization of function in the brain. Ferrier's strongest evidence was a monkey who suffered from hemiplegia, paralysis affecting one side of the body only, after a cerebral lesion. A committee, including Langley, was made up to investigate. Both the dog and the monkey were chloroformed. The right hemisphere of the dog was delivered to Cambridge for examination. Sherrington performed a histological examination of the hemisphere, acting as a junior colleague to Langley. In 1884, Langley and Sherrington reported on their findings in a paper. The paper was the first for Sherrington.[1] Travel Edit In the winter of 1884–1885, Sherrington left England for Strasbourg. There, he worked with Goltz. Goltz, like many others, positively influenced Sherrington. Sherrington later said of Goltz that: "[h]e taught one that in all things only the best is good enough."[1] A case of asiatic cholera had broken out in Spain in 1885. A Spanish doctor claimed to have produced a vaccine to fight the outbreak. Under the auspices of Cambridge University, the Royal Society of London, and the Association for Research in Medicine, a group was put together to travel to Spain to investigate. C.S. Roy, J. Graham Brown, and Sherrington formed the group. Roy was Sherrington's friend and the newly elected professor of pathology at Cambridge. As the three travelled to Toledo, Sherrington was skeptical of the Spanish doctor.[28] Upon returning, the three presented a report to the Royal Society. The report discredited the Spaniard's claim. Sherrington did not meet Santiago Ramón y Cajal on this trip. While Sherrington and his group remained in Toledo, Cajal was hundreds of miles away in Zaragoza.[28] Later that year Sherrington travelled to Rudolf Virchow in Berlin to inspect the cholera specimens he procured in Spain. Virchow later on sent Sherrington to for a six weeks' course in technique. Sherrington ended up staying with Koch for a year to do research in bacteriology. Under these two, Sherrington parted with a good foundation in physiology, morphology, histology, and pathology.[30] During this period he may have also studied with Waldeyer and Zuntz. In 1886, Sherrington went to Italy to again investigate a cholera outbreak. While in Italy, Sherrington spent much time in art galleries. It was in this country that Sherrington's love for rare books became an obsession.[28] Employment Edit C.S. Roy and Charles Scott Sherrington (right), at the door of the Old Pathological Laboratory, Cambridge, 1893 In 1891, Sherrington was appointed as superintendent of the Brown Institute for Advanced Physiological and Pathological Research of the University of London, a center for human and animal physiological and pathological research.[28][29] Sherrington succeeded Sir Victor Alexander Haden Horsley.[34] There, Sherrington worked on segmental distribution of the spinal dorsal and ventral roots, he mapped the sensory dermatomes, and in 1892 discovered that muscle lakhasly.com © ﺗﻢ ﺗﻠﺨﻴﺺ اﻟﻨﺺ ﺑﻮاﺳﻄﺔ ﻣﻮﻗﻊ ﻟﺨﺼﻠ spindles initiated the stretch reflex. The institute allowed Sherrington to study many animals, both small and large. The Brown Institute had enough space to work with large primates such as apes. Liverpool Edit Sherrington's first job of full-professorship came with his appointment as Holt Professor of Physiology at Liverpool in 1895, succeeding Francis Gotch.[28] With his appointment to the Holt Chair, Sherrington ended his active work in pathology.[1] Working on cats, dogs, monkeys, and apes that had been bereaved of their cerebral hemispheres, he found that reflexes must be considered integrated activities of the total organism, not just the result of activities of the so-called reflex-arcs, a concept then generally accepted.[34] There he continued his work on reflexes and reciprocal innervation. His papers on the subject were synthesized into the Croonian lecture of 1897. Sherrington showed that muscle excitation was inversely proportional to the inhibition of an opposing group of muscles. Speaking of the excitation-inhibition relationship, Sherrington said "desistence from action may be as truly active as is the taking of action." Sherrington continued his work on reciprocal innervation during his years at Liverpool. Come 1913, Sherrington was able to say that "the process of excitation and inhibition may be viewed as polar opposites [...] the one is able to neutralize the other." Sherrington's work on reciprocal innervation was a notable contribution to the knowledge of the spinal cord.[1] Oxford Edit As early as 1895, Sherrington had tried to gain employment at Oxford University. By 1913, the wait was over. Oxford offered Sherrington the Waynflete Chair of Physiology at Magdalen College.[1] The electors to that chair unanimously recommended Sherrington without considering any other candidates.[28] Sherrington enjoyed the honor of teaching many bright students at Oxford, including Wilder Penfield, who he introduced to the study of the brain. Several of his students were Rhodes scholars, three of whom - Sir John Eccles, Ragnar Granit, and Howard Florey - went on to be Nobel laureates.[35] Sherrington also influenced American pioneer brain surgeon Harvey Williams Cushing. Sherrington's philosophy as a teacher can be seen in his response to the question of what was the real function of Oxford University in the world. Sherrington said: "after some hundreds of years of experience we think that we have learned here in Oxford how to teach what is known. But now with the undeniable upsurge of scientific research, we cannot continue to rely on the mere fact that we have learned how to teach what is known. We must learn to teach the best attitude to what is not yet known. This also may take centuries to acquire but we cannot escape this new challenge, nor do we want to."[28] Box of microscope slides carrying the plaque:"Sir Charles Sherrington's Histology Demonstration Slides: St Thomas's Hospital: 1886–1895; Liverpool University: 1895–1915; Oxford University: 1914–1935" While at Oxford, Sherrington kept hundreds of microscope slides in a specially constructed box labelled "Sir Charles Sherrington's Histology Demonstration Slides". As well as histology demonstration slides, the box contains slides which may be related to original breakthroughs such as cortical localization in the brain; slides from contemporaries such as Angelo Ruffini and Gustav Fritsch; and slides from colleagues at Oxford such as John Burdon-Sanderson – the first Waynflete Chair of Physiology – and Derek Denny-Brown, who worked with Sherrington at Oxford (1924–1928)).[36] Sherrington's teachings at Oxford were interrupted by . When the war started, it left his classes with only nine students. During the war, he laboured at a shell factory to support the war and to study fatigue in general, but specifically industrial fatigue. His weekday work hours were from 7:30am to 8:30pm; and from 7:30am to 6:00pm on the lakhasly.com © ﺗﻢ ﺗﻠﺨﻴﺺ اﻟﻨﺺ ﺑﻮاﺳﻄﺔ ﻣﻮﻗﻊ ﻟﺨﺼﻠ weekends.[28] In March 1916, Sherrington fought for women to be admitted to the medical school at Oxford. Retirement Edit Charles Sherrington retired from Oxford in the year of 1936.[1] He then moved to his boyhood town of Ipswich, where he built a house.[30] There, he kept up a large correspondence with pupils and others from around the world. He also continued to work on his poetic, historical, and philosophical interests.[35] From 1944 until his own death he was President of the Ipswich Museum, on the committee of which he had previously served.[37] Sherrington's mental faculties were crystal clear up to the time of his sudden death, which was caused by a sudden heart failure at age 94. His bodily health, however, did suffer in old age. Arthritis was a major burden of his.[30] Speaking of his condition, Sherrington said "old age isn't pleasant[,] one can't do things for oneself."[1] The arthritis put Sherrington in a nursing home in the year before his death, in 1951.[35] Family Edit On 27 August 1891, Sherrington married Ethel Mary Wright (d.1933), daughter of John Ely Wright of Preston Manor, Suffolk, England. They had one child, a son named Charles ("Carr") E.R. Sherrington, who was born in 1897.[30] His wife was both loyal and lively. She was a great host. On weekends during the Oxford years the couple would frequently host a large group of friends and acquaintances at their house for an enjoyable afternoon.[1] Noted publications Edit The Integrative Action of the Nervous System Published in 1906,[15] this was a compendium of ten of Sherrington's Silliman lectures, delivered at in 1904.[38] In the publication, he discussed neuron theory, the "synapse" (a term he had introduced in 1897, the word itself suggested by classicist A. W. Verrall[39]), communication between neurons, and a mechanism for the reflex-arc function.[11] The work effectively resolved the debate between neuron and reticular theory in mammals, thereby shaping our understanding of the central nervous system.[38] He expressed his theory that the nervous system acts as the coordinator of various parts of the body and that the reflexes are the simplest expressions of the interactive action of the nervous system, enabling the entire body to function toward one definite end at a time. He also pointed out that reflexes have to be goal-directive and purposive. Furthermore, he established the of postural reflexes and their dependence on the anti-gravity stretch reflex and traced the afferent stimulus to the proprioceptive end organs, which he had previously shown to be sensory in nature ("proprioceptive" was another term he had coined[11]). The work was dedicated to Ferrier.[30] Man on His Nature A reflection of Sherrington's philosophical thought. Sherrington had long studied the 16th century French physician Jean Fernel, and grew so familiar with him that he considered him a friend. In the years of 1937 and 1938, Sherrington delivered the Gifford lectures at the ; these focused on Fernel and his times, and came to form the principal content of Man on His Nature. The book was released in 1940, and a revised edition came out in 1951. It explores philosophical thoughts about the mind, the human existence, and God, in connection with natural theology.[40] Chapters of the book align with the twelve zodiac signs.[41] In his ideas on the mind and cognition, Sherrington introduced the idea that neurons work as groups in a "million-fold democracy" to produce outcomes rather than with central control.[42] The Assaying of Brabantius and other Verse A collection of previously published war-time poems. This was Sherrington's first major poetic release. The Assaying was published in 1925. Sherrington's poetic side was inspired by Johann Wolfgang von Goethe. Sherrington was fond of Goethe the poet, but not Goethe the scientist. Speaking of Goethe's scientific writings, Sherrington said "to appraise them is not a congenial task."[1] lakhasly.com © ﺗﻢ ﺗﻠﺨﻴﺺ اﻟﻨﺺ ﺑﻮاﺳﻄﺔ ﻣﻮﻗﻊ ﻟﺨﺼﻠ Mammalian Physiology: a Course of Practical Exercises The textbook was released in 1919 at the first possible moment after Sherrington's coming to Oxford and the end of the War.[1] Honours and awards References External links Last edited 7 days ago by Mary Mark Ockerbloom RELATED ARTICLES John Eccles (neurophysiologist) Australian neurophysioloigst Active stretching History of neuroscience aspect of history Wikipedia Content is available under CC BY-SA 3.0 unless otherwise noted. Privacy policyTerms of UseDesktop

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