US 20160286803A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2016/0286803 A1 HELLWEGE et al. (43) Pub. Date: Oct. 6, 2016

(54) ACTIVE COMPOUNDS COMBINATION Publication Classification CONTAINING FILUOPYRAM BACILLUS AND BOLOGICALLY CONTROL AGENT (51) Int. Cl. AOIN 43/40 (2006.01) (71) Applicants: BAYER INTELLECTUAL AOIN 63/04 (2006.01) PROPERTY GMBH, Monheim (DE); AOIN 63/00 (2006.01) BAYER CROPSCIENCE AG, (52) U.S. Cl. Monheim (DE) CPC ...... A0IN 43/40 (2013.01): A0IN 63/00 (2013.01); A0IN 63/04 (2013.01) (72) Inventors: Elke HELLWEGE, Langenfeld (DE): (57) ABSTRACT Heike HUNGENBERG, Langenfeld The present invention relates to active compound combina (DE) tions for reducing the damage of plants and plant parts as Assignees: BAYER INTELLECTUAL well as losses in harvested fruits or vegetables caused by (73) insects, nematodes or phytopathogens and which have fun PROPERTY GMBH; BAYER gicidal or nematicidal or insecticidal activity including any CROPSCIENCE AG combination of the three activities, in particular within a composition, which comprises (A) Fluopyram, (B) a spore (21) Appl. No.: 15/175,810 forming bacterium of the genera Bacillus, selected from Bacillus firmus, Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, Bacillus (22) Filed: Jun. 7, 2016 subtilis strain QST713, and (C) at least one biological control agent, in particular bacteria, fungi or yeasts, proto Zoa, viruses, entomopathogenic nematodes, inoculants, Related U.S. Application Data botanicals and products produced by microorganisms (62) Division of application No. 14/373.916, filed on Jul. including proteins or secondary metabolites. Moreover, the 23, 2014, filed as application No. PCT/EP2013/ invention relates to a method for curatively or preventively 051108 on Jan. 22, 2013. controlling insects, nematodes or phytopathogens on the plant, plant parts, harvested fruits or vegetables, to the use (30) Foreign Application Priority Data of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to Jan. 25, 2012 (EP) ...... 12152488.8 the treated seed. US 2016/0286803 A1 Oct. 6, 2016

ACTIVE COMPOUNDS COMBINATION 0008 Fluopyram and its manufacturing process starting CONTAINING FLUOPYRAM BACILLUS AND from known and commercially available compounds is BIOLOGICALLY CONTROL AGENT described in EP-A 1531 673 and WO 2004/O16088. 0009. A general description of the nematicidal activity of CROSS REFERENCE TO RELATED pyridylethylbenzamide derivatives is found in WO-A 2008/ APPLICATIONS 126922. A description of nematicidal activity of Bacteria, in particular Bacillus firmus is found in WO-A 1996/32840, a 0001. This application is a divisional application of Ser. description of nematicidal activity of Bacillus chitinosporus No. 14/373,916 (filed Jul. 23, 2014), which is a S371 is found in WO-A 982 1966. National Stage Application of PCT/EP2013/051108 (filed 0010. The use of bacteria such as Bacillus sp. as biologi Jan. 22, 2013), which claims priority to EP 12152488.8 cal control agent in Synergistic compositions with fungicides (filed Jan. 25, 2012), the contents of each of which are e.g. Fluopyram for controlling phytopathogenic organisms incorporated herein by reference in their entirety. in agriculture is described e.g. in US 2011/0110906 A, US 2010/0249193 A, US 20100/209410 A, EP 2460407 A and BACKGROUND WO 2012/016989. In these documents only binary mixtures 0002 1. Field of the Invention of the biological control agent and Fluopyram are disclosed. 0003. The present invention relates to active compound WO 2012/038480 A discloses seeds of a plant comprising combinations and compostions for reducing the damage of (a) a gene preferably AXmi031, and AXn2 (producing pro plants and plant parts as well as losses in harvested fruits or teins of Bacillus thuringiensis), (b) a biological control vegetables caused by insects, nematodes or phytopathogens agent preferably Bacillus firmus CNCM I-1582, (c) one or and which have fungicidal or nematicidal or insecticidal more insecticides (including biological control agents pref activity including any combination of the three activities, in erably Pasteuria and Verticillum and (d) one or more fun particular within a composition, which comprises (A) Flu gicides preferably Fluopyram. In this document Pasteuria opyram, (B) a spore-forming bacterium of the genera Bacil and Verticillium are not further specified. lus, selected from Bacillus firmus, Bacillus cereus, Bacillus 0011 Since the environmental and economic require pumilis, Bacillus amyloliquefaciens, Bacillus subtilis strain ments imposed on modern-day crop protection compositions GB03, Bacillus subtilis strain QST713, and (C) at least one are continually increasing, with regard, for example, to the biological control agent, in particular bacteria, fungi or spectrum of action, toxicity, selectivity, application rate, yeasts, protozoa, Viruses, entomopathogenic nematodes, formation of residues, and favourable preparation ability, inoculants, botanicals and products produced by microor and since, furthermore, there may be problems, for example, ganisms including proteins or secondary metabolites. More with resistances, a constant task is to develop new compo over, the invention relates to a method for curatively or sitions, in particular fungicidal or nematicidal agents, which preventively controlling insects, nematodes or phytopatho in some areas at least help to fulfil the abovementioned gens on the plant, plant parts, harvested fruits or vegetables, requirements. The present invention provides active com to the use of a combination according to the invention for the pound combinations/compositions which in Some aspects at treatment of seed, to a method for protecting a seed and not least achieve the stated objective. at least to the treated seed. 0004 2. Description of Related Art SUMMARY 0005 Fluopyram is defined to be the compound of the 0012. It has now been found, surprisingly, that the com formula (I) binations according to the invention not only bring about the additive enhancement of the spectrum of action with respect to the insects, nematodes or phytopathogens to be controlled (I) that was in principle to be expected but achieves a syner CF s1 C. gistic effect which extends the range of action of the component (A) and of the component (B) and of the com 2 ponent (C) in two ways. Firstly, the rates of application of N the component (A) and of the component (B) and of the component (C) are lowered whilst the action remains H equally good. Secondly, the combination still achieves a high degree of control of insects, nematodes or phytopatho 0006 as well as the N-oxides of the compound thereof. gens even where the two individual compounds have 0007 Fluopyram is a broad spectrum fungicide of the become totally ineffective in such a low application rate chemical class of pyridylethylbenzamide derivatives with range. This allows, on the one hand, a substantial broadening penetrant and translaminar properties for foliar, drip, drench of the spectrum of phytopathogenic fungi and nematodes and seed treatment applications on a wide range of different that can be controlled and, on the other hand, increased crops against many economically important plant diseases. safety in use. It is very effective in preventative applications against 0013. In addition to the fungicidal or nematicidal or powdery mildew species, grey mould and white mould insecticidal Synergistic activity, the active compound com species. It has an efficacy against many other plant diseases. binations according to the invention have further Surprising Fluopyram has shown activity in spore germination, germ properties which, in a wider sense, may also be called tube elongation and mycelium growth tests. At the bio synergistic, Such as, for example: broadening of the activity chemical level, fluopyram inhibits mitochondrial respiration spectrum to other insects, nematodes or phytopathogens, for by blocking the electron transport in the respiratory chain of example to resistant strains of plant diseases; lower appli Succinate Dehydrogenase (complex II-SDH inhibitor). cation rates of the active compound combination; Sufficient US 2016/0286803 A1 Oct. 6, 2016

control of pests with the aid of the active compound com pumilis, Bacillus amyloliquefaciens, Bacillus subtilis strain binations according to the invention even at application rates GB03, Bacillus subtilis strain QST713, and where the individual compounds show no or virtually no 0031 (C) at least one biological control agent selected activity; advantageous behaviour during formulation or dur from the group consisting of ing use, for example during grinding, sieving, emulsifying, 0032 (C1) bacteria, dissolving or dispensing; improved storage stability and 0033) (C2) fungi or yeasts, light stability; advantageous residue formation; improved 0034 (C3) protozoas, toxicological or ecotoxicological behaviour; improved prop 0035 (C4) viruses, erties of the plant so called plant physiology effects, for 0036 (C5) entomopathogenic nematodes, example better growth, increased harvest yields, a better 0037 (C6) inoculants, developed root system, a larger leaf area, greener leaves, 0038 (C7) botanicals, and (C8.1) Halpin (produced by stronger shoots, less seed required, lower phytotoxicity, Erwinia amylovora) for reducing overall damage of plants mobilization of the defence system of the plant, good and plant parts as well as losses in harvested fruits or compatibility with plants. Thus, the use of the active com vegetables caused by insects, nematodes or phytopathogens, pound combinations or compositions according to the inven 0039 with the proviso that the spore-forming bacterium tion contributes considerably to keeping young cereal stands (B) of the genera Bacillus and the biological control agent healthy, which increases, for example, the winter survival of (C) are not identical. the cereal seed treated, and also safeguards quality and yield. 0040. Accordingly, the present invention provides par Moreover, the active compound combinations according to ticularly an active compound combination comprising the invention may contribute to enhanced systemic action. 0041 (A) Fluopyram, Even if the individual compounds of the combination have 0042 (B) a spore-forming bacterium of the genera Bacil no sufficient systemic properties, the active compound com lus, selected from the group consisting of Bacillus firmus, binations according to the invention may still have this Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus property. In a similar manner, the active compound combi pumilis, Bacillus amyloliquefaciens, Bacillus subtilis strain nations according to the invention may result in higher long GB03, Bacillus subtilis strain QST713, and term efficacy of the fungicidal or nematicidal or nematicidal 0043 (C) one biological control agent selected from the action. group consisting of 0044 (C1) bacteria, DETAILED DESCRIPTION OF A PREFERRED 0045 (C2) fungi or yeasts, EMBODIMENT 0046 (C3) protozoas, 0047 (C4) viruses, 0014. The combinations or compositions according to the 0048 (C5) entomopathogenic nematodes, present invention are now described in detail: 0049 (C6) inoculants, 0015. Accordingly, the present invention provides an 0050 (C7) botanicals, and (C8.1) Harpin (produced by active compound combination comprising: Erwinia amylovora) for reducing overall damage of plants 0016 (A) Fluopyram, and plant parts as well as losses in harvested fruits or 0017 (B) a spore-forming bacterium of the genera Bacil vegetables caused by insects, nematodes or phytopathogens, lus, selected from the group consisting of Bacillus firmus, 0051 with the proviso that the spore-forming bacterium Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefa (B) of the genera Bacillus and the biological control agent ciens, Bacillus subtilis strain GB03, Bacillus subtilis strain (C) are not identical. QST713, and 0.052 The term active compound combination shall refer 0018 (C) at least one biological control agent selected to the species as well as to individual strains of the respec from the group consisting of tive species. 0019 (C1) bacteria, 0053. In particular, the spore-forming bacterium (B) of 0020 (C2) fungi or yeasts, the genera Bacillus is selected from the group consisting of 0021 (C3) protozoas, 0054 (B1) Bacillus firmus strain CNCM I-1582, in par 0022 (C4) viruses, ticular the spores (U.S. Pat. No. 6,406,690), 0023 (C5) entomopathogenic nematodes, 0055 (B2) Bacillus cereus strain CNCM I-1562, in par 0024 (C6) inoculants, ticular the spores, (U.S. Pat. No. 6,406,690), 0025 (C7) botanicals, and 0056 (B3) Bacillus amyloliquefaciens strain IN937a, 0026 (C8) products produced by microorganisms includ 0057 (B4) Bacillus amyloliquefaciens strain FZB42 ing proteins or secondary metabolites for reducing overall (product known as RhizoVitar R), damage of plants and plant parts as well as losses in 0058 (B5) Bacillus subtilis strain GB03 (marketed as harvested fruits or vegetables caused by insects, nematodes KodiakTM Gustafson LLC), or phytopathogens. 0059 (B6) Bacillus subtilis strain QST713 (marketed as 0027. The term active compound combination shall refer SerenadeTM by Agraquest), to the species as well as to individual strains of the respec 0060 (B7) Bacillus pumilus strain GB34 (marketed as tive species YieldShieldTM by Gustafson LLC), 0028. Accordingly, the present invention provides par 0061 (B8) Bacillus pumilus strain QST2808 (marketed ticularly an active compound combination comprising as SonataTM by Agraquest). 0029 (A) Fluopyram, 0062. As used herein “biological control' is defined as 0030 (B) a spore-forming bacterium of the genera Bacil control of a phytopathogen or insect or an acarid or a lus, selected from the group consisting of Bacillus firmus, nematode by the use of a second organism or by the use of Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus botanicals or products produced by microorganisms includ US 2016/0286803 A1 Oct. 6, 2016

ing proteins or secondary metabolites, particularly (C8.1) (C1.13) Bacillus lactis, (C1.14) Bacillus laterosporus, (C1. Harpin. Particularly preferred is the control of nematodes. 15) Bacillus lentimorbus, (C1.16) Bacillus licheniformis, Particularly preferred “biological control is defined as (C1.17) Bacillus medusa, (C1.18) Bacillus megaterium, control of nematodes by the use of a second organism or by (C1.19) Bacillus metiens, (C1.20) Bacillus natto, (C1.21) the use of botanicals or products produced by microorgan Bacillus nigrificans, (C1.22) Bacillus popillae (neu Paeni isms including proteins or secondary metabolites, particu bacillus popilliae), (C1.24) Bacillus Siamensis, (C1.25) larly (C8.1) Harpin. Bacillus sphaericus (products known as VectoLeXS(R), (C1. 0063. In the context of the present invention, “control of 26) Bacillus subtilis var: amyloliquefaciens strain FZB24 a phytopathogen or insect oranacarid or a nematode” means (products known as Taegro(R), (C1.27) Bacillus thuringien a reduction in infestation by harmful phytopathogens or sis, in particular (C1.27a) Bacillus thuringiensis var. israel insect or an acarid or a nematode, compared with the ensis (products known as VectoBacR) or (C1.27b) Bacillus untreated plant measured as fungicidal or insecticidal or thuringiensis subsp. aizawai strain ABTS-1857 (products nematicidal efficacy, preferably a reduction by 25-50%, known as XenTari(R), or (C1.27c) Bacillus thuringiensis compared with the untreated plant (100%), more preferably subsp. kurstaki strain HD-1 (products known as Dipel(R) ES) a reduction by 40-79%, compared with the untreated plant or (C1.27d) Bacillus thuringiensis subsp. tenebrionis strain (100%); even more preferably, the infection by harmful NB 176 (products known as Novodor R FC) or (C1.27e) phytopathogens or insect or an acarid or a nematode, is Bacillus thuringiensis subsp. morrisoni or (C1.27f) Bacillus entirely suppressed (by 70-100%). The control may be thuringiensis var Son diego, (C1.28) Bacillus uniflagellatus, curative, i.e. for treatment of already infected plants, or (C1.29) Delftia acidovorans, in particular strain RAY209 protective, for protection of plants which have not yet been (products known as BioBoost(R), (C1.30) Lysobacter anti infected. bioticus, in particular strain 13-1 (cf. Biological Control 0064 Preferably, the compound (A) Fluopyram and the 2008, 45, 288-296), (C1.31) Pasteuria penetrans (synonym spore-forming bacterium (B) of the genera Bacillus is mixed Bacillus penetrans), (C1.32) Pseudomonas chlororaphis, in with one biological control agent (C), in particular bacteria, particular strain MA 342 (products known as Cedomon), fungi or yeasts, protozoa, viruses, entomopathogenic nema (C1.33) Pseudomonas proradix (products known as Prora todes, botanicals or products produced by microorganisms dix(R), (C1.34) Streptomyces galbus, in particular strain K61 including proteins or secondary metabolites, particularly (products known as Mycostop R, cf. Crop Protection 2006, (C8.1) Harpin, for reducing overall damage of plants and 25, 468-475), (C1.35) Streptomyces griseoviridis (products plant parts as well as losses in harvested fruits or vegetables known as MycostopR), (C1.36) Bacillus lautus, (C1.37) caused by insects, nematodes or phytopathogens. Bacillus atrophaeus, (C1.39) Bacillus mycoides, (C1.40) 0065 Mutants of the bacterial, fungal, nematodal or Bacillus acidoterrestris, (C1.41) Bacillus fastidiosus, (C1. protozoan strains having all the identifying characteristics of 42) Bacillus megaterium, (C1.43) Bacillus psychrosaccha the respective strain shall be included within the defimition rolyticus, (C1.44) Bacillus maroccanus, (C1.45) Bacillus of the biological control agent. megaterium C. (C1.46) Bacillus pantothenticus, (C1.47) 0066. The products produced by microorganisms includ Bacillus lentus, (C1.48) Bacillus badius, (C1.49) Bacillus ing proteins or secondary metabolites, particularly (C8.1) Smithi, (C1.50) Acinetobacter spec, (C1.51) Acinetobacter Harpin are characterized that they exhibit activity against lwoffii, (C1.52) Bacillus luciferensis, (C1.53) Chromobacte phytopathogenic insects, phytopathogenic nematodes or rium subtsugae strain PRAA4-1T (product known as phytopathogens. Grandevo), (C1.54) Pasteuria usgae (product known as 0067. Accordingly, in the present invention the biological EconemTM Biological Nematicide), (C1.55) Paenibacillus control agents (C) comprises bacteria, fungi or yeasts, polymyxa, (C1.56) Bacillus subtilis var: amyloliquefaciens protozoa, viruses, entomopathogenic nematodes, botanicals strain FZB24 (products known as Taegro (R), (C1.57) Serra and products produced by microorganisms including pro tia entomophila (product known as InvadeR), (C1.58) Bacil teins or secondary metabolites, particularly (C8.1) Harpin. lus chitinosporus (C1.59) Pseudomonas cepacia (ex Burk 0068 Accordingly, in the present invention biological holderia cepacia) strains M54 and J82. (C1.60) Bacillus control (C) agents consist of bacteria, fungi or yeasts, nematocida, in particular strain B-16: protozoa, viruses, entomopathogenic nematodes, botanicals 0073 (C2) fungi or yeasts selected from the group con and products produced by microorganisms including pro sisting of: teins or secondary metabolites, particularly (C8.1) Halpin. 0074 (C2.1) Ampelomyces quisqualis, in particular strain 0069. Accordingly, in the present invention biological AQ 10 (product known as AQ 10(R), (C2.2) Aureobasidium control agents are in particular bacteria, fungi or yeasts, pullulans, in particular blastospores of strain DSM14940 or protozoa, viruses, entomopathogenic nematodes, botanicals blastospores of strain DSM 14941 or mixtures thereof and products produced by microorganisms including pro (product known as Blossom Protect(R), (C2.3) Beauveria teins or secondary metabolites, particularly (C8.1) Harpin. bassiana, in particular strain ATCC 74040 (products known 0070. In particular, the biological control agent (C) is as Naturalis(R), from Intrachem) and strain GHA (products selected from the group comprising known as Mycotrol. BotaniGard), (C2.4) Candida oleop 0071 (C1) bacteria including spore-forming, root-colo hila, in particular strain O (products known as Nexy (R), nizing bacteria, or bacteria useful as biofungicide, bioinsec (C2.5) Coniothyrium minitans, in particular strain CON/M/ ticide or nematicide selected from the group consisting of 91-8 (products known as Contans (R), (C2.6) Dilophosphora 0072 (C1.1) Bacillus agri, (C1.2) Bacillus aizawaii, (C1. alopecuri (products known as Twist Fungus (R), (C2.7) 3) Bacillus albolactis, (C1.6) Bacillus coagulans,(C1.7) Gliocladium catenulatum, in particular strain J1446 (prod Bacillus endoparasiticus, (C1.8) Bacillus endorhythmos, ucts known as Prestop (R), (C2.8) Lecanicillium lecanii (C1.9) Bacillus azotoformans, (C1.10) Bacillus kurstaki, (formerly known as Verticillium lecanii), in particular (C1.11) Bacillus lacticola, (C1.12) Bacillus lactimorbus, conidia of strain KVO1 (products known as Mycotal(R), US 2016/0286803 A1 Oct. 6, 2016

VertialecR), (C2.9) Metarhizium anisopliae, in particular (C5.4) Steinernema carpocapsae, (C5.5) Heterorhabditis strain F52 (products known as BIO 1020), (C2.10) spp., (C5.6) Heterorhabditis heliothidis, (C5.7) Hexamermis Metschnikovia fructicola, in particular the strain NRRL spp., (C5.8) Amphimermis spp., (C5.9) Mermis nigrescens, Y-30752 (products known as Shemer (R), (C2.11) (C5.10) Agamermis decaudata, (C5.11) Maupasina Weissi, Microsphaeropsis ochracea (products known as MicroXR), (C5.12) Subulura spp., (C5.13) Seuratum cadarachense, (C2.12) Muscodor albus, in particular strain QST 20799 (C5.14) Ptery godermatites spp., (C5.15) Abbreviata cau (products known as QRD300), (C2.13) Nomuraea rileyi, in casica, (C5.16) Spirura guianensis, (C5.17) Diplotriaena particular strains SA86101, GU87401, SR86151, CG128 spp., (C5.18) Tetrameres spp., (C5.19) Acuaria spp., (C5.20) and VA9101 (C2.14) Paecilomyces lilacinns, in particular Gongylonema spp., (C5.21) Protrellatus spp., (C5.22) spores of P lilacinus strain 251 (products known as Bio Hydromermis spp., (C5.23) Cameronia spp., (C5.24) Physa Act(R), cf. Crop Protection 2008, 27, 352-361), (C2.15) Paecilomyces fumosorosens (also known as Isaria filmOSO loptera spp., (C5.25) Chitwoodiella ovofilamenta, (C5.26) rosae, products known as PFR-97TM 20% WDG), (C2.16) Gynopoecilia pseudovipara, (C5.27) Parasity lenchus spp., Penicillium bilaii, in particular strain ATCC22348 (products (C5.28) Neoparasity lenchus rugulosi, (C5.29) Sulphurety known as JumpStart(R), PB-50, Provide), (C2.17) Pichia lenchus elongatus, (C5.30) Sphaerulariopsis spp., (C5.31) anomala, in particular strain WRL-076, (C2.18) Psend Allantonema spp., (C5.32) Contortvlenchus spp., (C5.33) Ozyma flocculosa, in particular strain PF-A22 UL (products Bovienema spp., (C5.34) Parasitaphelenchus spp., (C5.35) known as Sporodex (RL), (C2.19) Pythium oligandrum Parasitorhabditis spp., (C5.36) Phasmarhabditis hermaph DV74 (products known as Polyversum), (C2.20) rodita, (C5.37) Romanomermis spp., (C5.38) Octomyomer Trichoderma asperellum, in particular strain ICC 012 (prod mis spp., (C5.39) Strelkovimermis peterseni, (C5.40) ucts known as Bioten(R), (C2.21) Trichoderma harzianum, Perutilimermis culicis, (C5.41) Culicinermis spp., (C5.42) in particular T. harzianum T39 (products known as Tricho Empidomermis spp., (C5.43) Gastromermis spp., (C5.44) dex(R), (C2.22) Beauveria brongniartii (products known as Isomermis spp., (C5.45) Neonesomermis spp., (C5.46) Lim Beaupro), (C2.23) Asohersonia aley rodes, (C2.24) Hirsute nomermis spp., (C5.47) Mesomermis spp., and (C5.48) lia thompsoni (products known as Mycohit), (C2.25) Lagen Xenorhabdus luminescence (entomopathogenic bacteria idium giganteum (products known as LAGINEXR), (C2.26) symbiotically associated with nematodes); Myrothecium verrucaria strain AARC-0255 (products I0081 (C6) Inoculants selected from the group consisting known as DiTeraTM), (C2.27) Pandora delphacis, (C2.28) of Tsukamurella paurometabola (products known as Heber NemR), (C2.29) Verticillium lecanii, in particular strain I0082 (C6.1) Rhizobium leguminosarum, (C6.2) Rhizo DAOM198499 and DAOM216596, (C2.30) ARF 18 (Ar bium tropici, (C6.3) Rhizobium loti, (C6.4) Rhizobium tri kansas Fungus 18), (C2.31) Trichoderma atroviride (prod folii, (C6.5) Rhizobium meliloti, (C6.6) Rhizobium fredii, ucts known as EsquiveR) (C2.32) Glomus aggregatum, (C6.7) Azorhizobium caulinodans, (C6.8) Pseudomonas, (C2.33) Glomus etunicatum, (C2.34) Glomus intraradices, (C6.9) Azospirillum, (C6.10) Azotobacter, (C6.11) Strepto (C2.35) Glomus mosseae, (C2.36) Glomus deserticola, (C2. myces, (C6.12) Burkholdia, (C6.13) Agrobacterium, (C6.14) 37) Glomus clarum, (C2.38) Glomus brasilianum, (C2.39) Endo Mycorhiza, (C6.15) Ecto Mycorhiza, (C6.16) Vesicu Glomus monosporum, (C2.40) Gigaspora margarita, (C2. lar Arbuscular (VA) Mycorhiza, (6.17) Bradyrhizobium, 41) Rhizopogon villosullus, (C2.42) Rhizopogon. luteolus, I0083 (C7) Botanicals (or: plant extracts) selected from (C2.43) Rhizopogon. amylopogon, (C2.44) Rhizopogon. full the group consisting of vigleba, (C2.45) Pisolithus tinctorius, (C2.46) Scleroderma I0084 (C7.1) Thymus oil, (C7.2) Azadirachtin (Neem), cepa, (C2.47) Scleroderma citrinum, (C2.48) Suillus granu (C7.3) Pyrethrum, (C7.4) Cassia nigricans, (C7.5) Quassia latus, (C2.49) Suillus punctatapies, (C2.50) Laccaria lac amara, (C7.6) Rotenon (C7.7) Garlic, (C7.8) Quillaja, cata, (C2.51) Laccaria bicolor, (C7.9) Sabadilla, in particular Veratrin, (C7.10) Ryania, in 0075 (C3) Protozoas selected from the group consisting particular Ryanodine, (C7.11) Viscum album (mistel), (C7. of 12) mugwort or common tansy (Tanacetum vulgare), (C7. 0076 (C3.1) Nosema locustae, (C3.2)Thelohania, (C3.3) 13) Artemisia absinthium, (C7.14) Urtica dioica, (C7.15) Vairimorpha: Symphytum officinale, (C7.16) Tropaeulum majus, (C7.17) 0077 (C4) Viruses selected from the group consisting of Quercus, (C7.18) mustard flour, (C7.19) Chenopodium 0078 (C4.1) Gypsy moth (Lymantria dispar) nuclear anthelminticum, (C7.20) Dryopteris filix-mas, (C7.21) bark polyhedrosis virus (NPV), (C4.2)Tussock moth (Lymantrii of Chinese bittersweet (Celastrus orbiculatus), (C7.22) dae) NPV. (C4.3) Heliothis NPV. (C4.4) Pine sawfly (Neo Equisetum arvense, (C7.23) bark of Celastus angulatus, diprion) NPV, and (C4.5) Codling moth (Cydia pomonella) (C7.24) Laminarin (Brown Algae), (C7.25) Alginic acid granulosis virus (GV):), (C4.6) Adoxophyes Orana GV (Brown Algae), (C7.26) Chitin/Chitinosan. (C7.27) Che (product known as CapeX(R), (C4.7) Helicoverpa armigera nopodium quinoa (product known as Head-sUp), (C7.28) NPV (products known as Vivus Max R, Vivus Gold(R) or Melaleuca alternifolia (products known as Timorex Gold(R). Gemstar(R), (C4.8) Spodoptera exigua NPV. (C4.9) Spodop (C7.29) Sesame oil (product known as Dragongfire tera littoralis NPV. (C4.10) Spodoptera litura NPV. (C4.11) CCPTM); Neodiprion abietis NPV (product known as ABIETIVTM), (C4.12) Neodiprion sertifer NPV (product known as Neo I0085 (C8) Products produced by microorganisms includ check-STM); ing proteins or secondary metabolites selected from the 0079 (C5) entomopathogenic nematodes selected from group consisting of the group consisting of I0086 (C8.1) Harpin (produced by Erwinia amylovora, 0080 (C5.1) Steinernema ssp. (=Neoaplectana spp.), products known as Harp-N-TekTM, Messenger(R), EmployTM (C5.2) Steinernema scapterisci, (C5.3) Steinernema feltiae, ProActTM), (C8.2) Thymol. US 2016/0286803 A1 Oct. 6, 2016

0087. In particular, the biological control agent (C) is (C1.27v) Bacillus thuringiensis strain CR-371 (Acces selected from the group comprising sion No. ATCC 55273), (C1.28) Bacillus uniflagellatus, 0088 (C1) bacteria including spore-forming, root-colo (C1.29) Delfia acidovorans, in particular strain nizing bacteria, or bacteria useful as biofungicide, bioinsec RAY209 (products known as BioBoose(R), (C1.30) ticide or nematicide selected from the group consisting of Lysobacter antibioticus, in particular strain 13-1 (cf. I0089 (C1.1) Bacillus agri, (C1.2) Bacillus aizawai, Biological Control 2008, 45, 288-296), (C1.31) Pas (C1.3) Bacillus albolactis, (C1.6) Bacillus coagulans, teuria penetrans (synonym Bacillus penetrans), (C1.32) (C1.7) Bacillus endoparasiticus, (C1.8) Bacillus endo Pseudomonas chlororaphis, in particular strain MA rhythmos, (C1.9) Bacillus azotoformans, (C1.10) 342 (products known as Cedomon from Bioagri, S) or Bacillus kurstaki, (C1.11) Bacillus lacticola, (C1.12) strain 63-28 (product known as ATEze from EcoSoil Bacillus lactimorbus, (C1.13) Bacillus lactis, (C1.14) Systems, US), (C1.33) Pseudomonas proradix (prod Bacillus laterosporus, (C1.15) Bacillus lentimorbus, ucts known as Proradix(R), (C1.34) Streptomyces gal (C1.16) Bacillus licheniformis, in particular strain bus, in particular strain K61 (Accession No. DSM SB3086 (product known as EcoGuard TM Biofungicide 7206, products known as Mycostop(R), cf. Crop Protec or Green Releaf from Novozymes Biologicals, US), tion 2006, 25, 468-475) or strain NRRL30232, (C1.35) (C1.17) Bacillus medusa, (C1.18) Bacillus megate Streptomyces griseoviridis (products known as rium, (C1.19) Bacillus metiers, (C1.20) Bacillus natto, MycostopR), (C1.36) Bacillus lautus, (C1.37) Bacillus (C1.21) Bacillus nigrificans, (C1.22) Bacillus popillae atrophaeus, (C1.39) Bacillus mycoides, in particular (also known as Paenibacillus popilliae, product known isolate J(product known as Bm) from Certis USA) or as Milky spore disease from St. Gabriel Laboratories), strain 683 or strain AQ726 (Accession No. NRRL (C1.24) Bacillus siamensis, (C1.25) Bacillus sphaeri B21664), (C1.40) Bacillus acidoterrestris, (C1.41) cus, in particular Serotype H5a5b strain 2362, (product Bacillus fastidiosus, (C1.42) Bacillus megaterium known as VectoLex(R) from Valent BioSciences, US), (products known as BioarcR, from BioArc), or strain (C1.26) Bacillus subtilis var: amyloliquefaciens strain YFM3.25. (C1.43) Bacillus psychrosaccharolyticus, FZB24 (products known as Taegro(R), Rhizopro, (C1.44) Bacillus maroccanus, (C1.45) Bacillus mega FZB24), (C1.27) Bacillus thuringiensis, in particular terium C. (C1.46) Bacillus pantothenticus (also known (C1.27a) Bacillus thuringiensis var. israelensis (sero as Virgibacillus pantothenticus), in particular strain type H-14), in particular strain AM65-52 (Accession ATCC 14576/DSM 491, (C1.47) Bacillus lentus, (C1. No. ATCC 1276, products known as VectoBac(R), from 48) Bacillus badius, (C1.49) Bacillus smithi, (C1.50) Valent BioSciences, US) or strain BMP 144 (product Acinetobacter spec, (C1.51) Acinetobacter lwoffii, (C1. known as Aquabac from Becker Microbial Products 52) Bacillus luciferensis, (C1.53) Chromobacterium Ill.), (C1.27b) Bacillus thuringiensis subsp. aizawai subtsugae, in particular strain PRAA4-1T (product strain ABTS-1857 (products known as XenTari(R) from known as Grandevo, from Marrone Bio Innovations), Bayer CropScience, Del.) or strain GC-91 (Accession (C1.54) Pasteuria usgae (product known as EconemTM No. NCTC 11821), or serotype H-7, (products known Biological Nematicide), (C1.55) Paenibacillus poly as Florbac WG from Valent BioSciences, US) or (C1. myxa, in particular strain AC-1 (product known as 27c) Bacillus thuringiensis subsp. kurstaki strain HD-1, Topseed from Green Bio-tech Company Ltd.), (C1.57) (products known as Dipel(R) ES from Valent BioSci Serratia entomophila (product known as InvadeR), ences, US), or strain BMP 123 from Becker Microbial (C1.58) Bacillus chitinosporus, in particular strain Products, Ill., or strain ABTS 351 (Accession No. AQ746 (Accession No. NRRL B-21618), (C1.59) ATCC SD-1275), or strain PB 54 (Accession No. Pseudomonas cepacia (ex Burkholderia cepacia, prod CECT 7209), or strain SA 11 (Accession No. NRRL uct known as Deny from Stine Microbial Products), B-30790), or strain SA 12 (Accession No. NRRL (C1.60) Bacillus nematocida, in particular strain B-16, B-30791), or strain EG 2348 (Accession No. NRRL (C1.61) Bacillus circulars, (C1.62) Brevibacillus lat B-18208) or (C1.27d) Bacillus thuringiensis subsp. erosporus (also known as Bacillus laterosporus), in tenebrionis strain NB 176 (products known as particular strain ATCC 64 or strain NRS 1111 or strain Novodor R FC from BioFa, Del.) or (C1.27e) Bacillus NRS 1645 or Strain NRS 1647 or Strain BPM3 or Strain thuringiensis subsp. morrisoni or (C1.270 Bacillus G4 or strain NCIMB 41419, (C1.63) Corynebacterium thuringiensis var. San die go (product known as paurometabolum, (C1.64) Lactobacillus acidophilus M-One(R) from Mycogen Corporation, US) or (C1.27g) (products known as Fruitsan R) from Inagrosa-Indus Bacillus thuringiensis Subsp. thuringiensis (serotype 1) trias Agrobiologicas, S.A), (C1.65) Paenibacillus alvei, MPPL002, or (C1.27h) Bacillus thuringiensis var. in particular strain T36 or strain III3DT-1A or strain aegyptii, or(C1.27k) Bacillus thuringiensis var. III2E or strain 46C3 or strain 2771, (C1.66) Paeniba colmeri, or (C1.271) Bacillus thuringiensis var. darm cillus macerans, (C1.67) Pasteuria nishizawae, in par stadiensis, or (C1.27m) Bacillus thuringiensis var. den ticular strain Pnl (C1.68) Pasteuria ramosa, (C1.69) drolimus, or (C1.27n) Bacillus thuringiensis var. gal Pasteuria thornei, (C1.70) Pseudomonas aeruginosa, leriae, or (C1.27o) Bacillus thuringiensis var. in particular strains WS-1 or PN1, (C1.71) Pseudomo japonensis, in particular strain Bulbul or (C1.27r) nas aureofaciens, in particular strain TX-1 (product Bacillus thuringiensis var. 7216 (products known as known as Spot-Less Biofungicide from Eco Soils Sys Amactic, Pethian), or (C1.27s) Bacillus thuringiensis tems, CA), (C1.72) Pseudomonas fluorescens, in par var. T36, or (C1.27t) Bacillus thuringiensis strain ticular strain A506 (products known as Blightban or BDi32 (Accession No. NRRL B-21530) from Agra BlightBan A506 from NuFarm), (C1.73) Pseudomonas quest, or (C1.27u) Bacillus thuringiensis strain AQ52 putida, (C1.74) Pseudomonas resinovorans (products (Accession No. NRRL B-21619) from Agraquest, or known as Solanacure), (C1.75) Pseudomonas Syringae, US 2016/0286803 A1 Oct. 6, 2016

in particular strain MA-4 (products known as BioSave Pasteuria sp., in particular strain PTA-9643, (C1.98) from EcoScience, US), (C1.76) Serratia marcescens, in Agrobacterium radiobacter, in particular strain K84 particular strain SRM (MTCC8708) or strain R35, (products known as Galltrol-A from Ag-BioChem) or (C1.77) Streptomyces candidus, in particular strain strain K1026 (products known as Nogall, Becker Y21007-2, (products known as Bio-bac), (C1.78) Underwood), (C1.99) Agrobacterium vitis, in particular Streptomyces lydicus, in particular strain WYCD108 the non-pathogenic strain VAR03-1, (C1.100) (products known as ActinovateSP) or strain WYEC108 Azorhizobium caulinodans, preferably strain ZB-SK-5, (C1.101) Azospirillum amazonense, (C1.102) (products known as Actino-iron from Natural Indus Azospirillum brasilense, (C1.103) Azospirillum halo tries), (C1.79) Streptomyces Saraceticus, (C1.80) Strep praeference, (C1.104) Azospirillum irakense, (C1.105) tomyces venezuelae, (C1.81) Xenorhabdus nemato Azospirillum hpoferum, (C1.106), Azotobacter chroo phila, (C1.82) Agrobacterium radiobacter, (C1.83) coccum, preferably strain H23 (CECT 4435), (C1.107) Bacillus mojavensis, especially strain CECT-7666, (C1. Azotobacter vinelandii, preferably strain ATCC 12837, 84) Pantoea agglomerans, in particular strain E325 (C1.108) Bacillus acidocaldarius, (C1.109) Bacillus (products known as Bloomtime Biological FD Biope acidoterrestris, (C1.110) Bacillus alcalophilus, (C1. sticide), (C1.85) Streptomyces colombiensis, (C1.86) 111) Bacillus alvei, (C1.112) Bacillus aminoglucosidi Streptomyces sp. WYE 20 (KCTC 0341 BP) and WYE cus, (C1.113) Bacillus aminovorans, (C1.114) Bacillus 324 (KCTC 0342BP), (C1.87) Bacillus brevis (also amylolyticus (also known as Paenibacillus amylolyti known as Brevibacillus brevis, product known as Bre cus), (C1.115) Bacillus aneurinolyticus, (C1.116) visin), in particular strain SS86-3 or strain SS86-4 or Bacillus subtilis isolate B246, for example in form of strain SS86-5 or strain 2904, (C1.88) Erwinia caroto the commercially available product Avogreen from RE vora (also known as Pectobacterium carotovorum) at UP), (C1.117) Bacillus tequilensis, in particular carotovora (product known as Biokeeper), (C1.89) strain NII-094, (C1.118) Bacillus sp. strain AQ175 Xanthomonas campestris pv vesicatoria (product (ATCC Accession No. 55608), (C1.119) Bacillus sp. known as Camprico), (C1.90) Pasteuria reniformis, in strain AQ177 (ATCC Accession No. 55609), (C1.120) particular strain Pr3, (C1.91) Burkholderia spec strain Bacillus sp. strain AQ178 (ATCC Accession No. A396 (Accession No. NRRL B-50319, product known 53522), (C1.121) Gluconacetobacter diazotrophicus, as MBI-206 TGAI from Marrone Bio Innovations), (C1.122) Herbaspirilum rubrisubalbicans, (C1.123) (C1.92) Bacillus firmus CNCMI-1582, in particular the Herbaspirilum seropedicae, (C1.124) Lactobacillus sp. spores (cf. U.S. Pat. No. 6,406,690, products known as (products known as Lactoplant from LactoPAFI), (C1. Bionem, VOTIVO), (C1.93) Bacillus cereus (syn 125) Lysobacter enzymogenes, in particular strain C3 onyms: Bacillus endorhythmos, Bacillus medusa), in (cf. J Nematol. 2006 June; 38(2): 233-239), (C1.126) particular spores of Bacillus cereus strain CNCM Rhodococcus globerulus strain AQ719 (Accession No. 1-1562 (cf. U.S. Pat. No. 6,406,690), or strain BP01 NRRL B21663, from AgraGuest), (C1.127) Streptomy (ATCC 55675, product known as Mepichlor from ces sp. Strain NRRL B-301.45 (from Agraquest), (C1. Arysta, US or Mepplus, Micro-Flo Company LLC, 128) Streptomyces acidiscabies, in particular strain US), (C1.94) Bacillus amyloliquefaciens strain IN937a RL-110T, (product known as MBI-005EP from Mar or strain FZB42 (DSM 231179, product known as rone Bioinnovations), (C1.129) Streptomyces goshik RhizoVital(R) from ABiTEP DE), or strain B3, or strain iensis, (C1.130) Streptomyces lavendulae, (C1.131) D747, (products known as Bacstar R) from Etec Crop Streptomyces prasinus (cf. "Prasinons A and B: potent Solutions, NZ, or Double NickelTM from Certis, US), insecticides from Streptomyces prasinus’ Applied (C1.95) Bacillus subtilis, in particular strain GB03 microbiology 1973 Nov), (C1.132) Streptomyces rimo (Accession No. ATCC SD-1397, product known as KodiakR from Bayer Crop Science, DE) or strain SuS. QST713/AQ713 (Accession No. NRRL B-21661, 0090 (C2) fungi or yeasts selected from the group con products known as Serenade QST 713C), Serenade Soil sisting of: and Serenade Max from AgraGuest, US) or strain AQ 0091 (C2.1) Ampelomyces quisqualis, in particular strain 153 (ATCC accession No. 55614) or strain AQ743 AQ 10 (product known as AQ 10(R), (C2.2) Aureobasidium (Accession No. NRRL B-21665) or strain DB 101, pullulans, in particular blastospores of strain DSM14940 or (products known as Shelter from Dagutat Bio lab, ZA) blastospores of strain DSM 14941 or mixtures thereof or strain DB 102, (products known as Artemis from (product known as Blossom Protect(R), (C2.3) Beauveria Dagutat Bio lab, ZA) or strain MBI 600, (products bassiana, in particular strain ATCC 74040 (products known known as Subtilex from Becker Underwood, US) or as Naturalis(R) or strain GHA (products known as Mycotrol, strain QST30002/AQ30002 (Accession No. NRRL BotaniGard) or strain ATP02 (DSM 24665) or strain CG716 B-50421, cf. WO 2012/087980) or strain QST30004/ (product known as BoveMax), (C2.4) Candida oleophila, in AQ30004 (Accession No. NRRL B-50455, cf. WO particular strain O (products known as Nexy (R) or strain 2012/087980), (C1.96) Bacillus pumilus, in particular I-182 (products known as ASPIRE(R), Decco I-182), (C2.5) strain GB34 (Accession No. ATCC 700814, products Coniothyrium minitans, in particular strain CON/M/91-8 known as Yield Shield(R) from Bayer CropScience, DE) (DSM-96.60) (products known as Contans.(R), (C2.6) Dilo or strain QST2808 (Accession No. NRRL B-30087, phosphora alopecuri (products known as Twist FungusTM). products known as Sonata QST 2808(R) from Agra (C2.7) Gliocladium catenulatum, in particular strain J1446 Quest, US), or strain BU F-33 (product known as (products known as Prestop(R), (C2.8) Lecanicillium lecanii Integral F-33 from Becker Underwood, US), or strain (formerly known as Verficillium lecanii), in particular AQ717 (Accession No. NRRL B21662, (C1.97) Pas conidia of strain KVO1 (products known as Mycotal(R), teuria sp., in particular strain SD-5832 and (C1.98) Vertialec(R), from Koppert/Alysta) or strain DAOM198499 or US 2016/0286803 A1 Oct. 6, 2016

DAOM216596, (C2.9) Metarhizium anisopliae, in particular tatapies, (C2.50) Laccaria laccata, (C2.51) Laccaria strain F52 (DSM 3884, ATCC 90448, products known as bicolor (C2. 52) Metarhizium flavoviride, (C2.53) Arthro BIO 1020, MET52) or var. acridum isolate IMI 330189/ botry's dactyloides, (C2.54) Arthrobotry's Oligospora, (C2. ARSEF 7486 (products known as Green MuscleR) (C2.10) 55) Arthrobotry's superba (C2.56) Aspergillus flavus strain Metschnikovia fruchcola, in particular the strain NRRL NRRL 21882 (product known as Afla-Guard(R), from Syn Y-30752 (products known as ShemerR), (C2.11) genta) or strain AF36 (product known as AF36), (C2.57) Microsphaeropsis ochracea (products known as MicroXR), Candida Saitoana, in particular strain NRRLY-21022 (prod (C2.12) Muscodor albus, in particular strain QST 20799 ucts known as BIOCURE(R) or BIOCOATR), (C2.58) (products known as QRD300), (C2.13) Nomuraea rileyi, in Chaetomium cupreum, (C2.59) Chaetonium globosum, (C2. particular strains SA86101, GU87401, SR86151, CG128 60) Chondrostereum purpureum, in particular strain and VA9101 (C2.14) Paecilomyces lilacinus, in particular PFC2139 , (C2.61) Cladosporium cladosporioides strain spores of P lilacinus strain 251 (AGAL 89/030550) (prod H39 (as described in EP2230918 Al), (C2.62) Conidiobolus ucts known as BioAct(R), cf. Crop Protection 2008, 27. obscurus, (C2.63) Cryptococcus albidus (product known as 352-361), (C2.15) Paecilomyces filmosoroseus (also known Yield Plus(R).), (C2.64) Cryptococcus flavescens, in particu as Isaria fumosorosae), in particular strain apopka 97 lar strain NRRLY-50378 and strain NRRLY-50379, (C2.65) (ATCC 20874) (products known as PFR-97TM 20% WDG, , Dactylaria candida, (C2.66) Entomophthora virulenta, PreFeRal(R) WG.), (C2.16) Penicillium bilaii, in particular (C2.67) Harposporium anguilluilae, (C2.68) Hirsutella strain ATCC22348 (products known as JumpStart(R), PB-50, minnesotensis, (C2.69) Hirsutella rhossiliensis, (C2.70) Provide), (C2.17) Pichia anomala, in particular strain WRL Meristacrum asterospermum, (C2.71) Microdochium 076, (C2.18) Pseudozyma flocculosa, in particular strain dimerum, in particular strain L13 (products known as ANTI PF-A22 UL (products known as Sporodex (RL), (C2.19) BOTR, Agrauxine), (C2.72) Monacrosporium Cionopagum, Pythium oligandrum, in particular strain DV74 (products (C2. 73) Monacrosporium psychrophilum, (C2. 74) Mona known as Polyversum) or strain M1 (ATCC 38472), (C2.20) crosporium drechsieri, (C2. 75) Monacrosporium gephy Trichoderma asperellum, in particular strain ICC 012 (also ropagum, (C2.76) Ophiostoma piliferum, in particular strain known as Trichoderma harzianum ICC012, products known D97 (products known as Sylvanex), (C2.77) Paecilomyces as Bioten(R) or strain SKT-1 (products known as Triderma(R) variotii, in particular strain Q-09 (product known as Nema or ECO-HOPE(R) or strain T34 (products known as T34 quim), (C2.78) Pochonia chiamydosporia (= Vercillium Biocontrol) or strain SF04 or strain TV1 (also known as chiamydosporiumi), (C2.79) Pseudozyma aphidis (C2.80) Trichoderma viride TV1) or strain T11 (also known as Stagonospora heteroderae, (C2.81) Stagonospora phaseoli, Trichoderma viride T25), (C2.21) Trichoderma harzianum, (C2.82) Talaromyces flavus, in particular strain V117b in particular T. harzianum T39 (products known as Tricho (products known as PROTUS(R), (C2.83) Trichoderma dex(R) or strain T-22 (products known as PLANT viride (also known as Trichoderma gamsii), in particular SHIELD(RT-22G, Rootshield, Turf Shield), or strain TH 35 strain ICC 080 (products known as REMEDIER(R) WP (products known as ROOT PROR) or strain TSTh20/PTA BiodermeR) and strain TV1 (products known as T. Viride 0317 or strain 1295-22 (products known as Bio-Trek), TV1, Agribiotec), (C2.84) Trichoderma harmatum, isolate (C2.22) Beauveria brongniarti (products known as Beau 382 (C2.85) Trichoderma koningii, (C2.86) Trichoderma pro), (C2.23) Aschersonia aley rodes, (C2.24) Hirsutella lignorum, (C2.87) Trichoderma polysporum, isolate IMI thompsoni (products known as Mycohit), (C2.25) Lagen 206039 (ATCC 20475), (C2.88) Trichoderma stromaticum, idium giganteum (products known as LAGINEXR), (C2.26) (C2.89) Trichoderma vixens (also known as Gliociadium Myrothecium verrucaria strain AARC-0255 (products virens), in particular strain GL-21 (products known as known as DiTeraTM), (C2.27) Pandora delphacis, (C2.28) SOILGARDR) or strain G41 (products known as BW240 Tsukamurella paurometabola, in particular strain C-924 WP Biological Fungicide), (C2.90) Ulociadium oudemansii, (products known as HeberNem(R), (C2.30) ARF 18 (Arkan in particular strain HRU3 (products known as BOTRY sas Fungus 18), (C2.31) Trichoderma atroviride in particular ZENR), (C2.91) Verticillium albo-atrum in particular strain strain CNCM 1-1237 (products known as Esquive(R) WP WCS850, (C2.92) Verticillium chiamydosporium, (C2.93) Sentinel(R), TenetR) or strain NMI No. V08/002387 or strain Verticillium dahlia isolate WCS 850 (products known as NMI No. V08/002389 or Strain NMI No. V08/002390 or Dutch Trig), (2.94) Zoophtora radicans, (2.95) Cylindro strain NMI No. V08/002388 (patent application US 2011/ carpon heteronema, (C2.96) Exophiala jeanselmei, (C2.97) 0009260) or strain ATCC 20476 (IMI 206040) or strain T11 Exophilia pisciphila, (C2.98) Fusarium aspergilus, (C2.99) (IM1352941) or strain LC52 (products known as Sentinel(R), Fusarium oxysporum, for example the non pathogenic strain Agrimm Technologies, (products known as EsquiveR) or Fo47 (product FUSACLEAN) or the non pathogenic strain strain NMI V08/002387, or strain NMI V08/002389 or 251/2RB (product known as BIOFOX(R), (C2.100) Strain SKT-1/FERMP-1651 or Strain SKT-2AFERMP-16511 Fusarium Solani, for example strain Fs-K (as described in or strain SKT-3/FERM P-17021 (described in JP3691264) patent application US20110059048), (C2.101) Gliocladium or strain L52 (product known as SENTINEL(R), (C2.32) roseum, in particular strain 321U, (C2.102) Mucor haemelis Glomus aggregatum, (C2.33) Glomus etunicatum, (C2.34) (products known as BIO-AVARD), (C2.103) Nematoctonus Glomus intraradices, (C2.35) Glomus mosseae, (C2.36) geogenius, (C2.104) Nematoctonus leiosporus, (C2.105) Glomus deserticola, (C2.37) Glomus clarum, (C2.38) Glo Phlebiopsis gigantea (products known as ROTSOPR), (C2. mus brasilianum, (C2.39) Glomus monosporum, (C2.40) 106) Trichoderma album (products known as BiozeidR), Gigaspora margarita, (C2.41) Rhizopogon villosullus, (C2. (C2.107) Trichoderma asperellum (products known as BIO 42) Rhizopogon. luteolus, (C2.43) Rhizopogon. amy TAMTM) and, (C2.108) Trichoderma gamsii (products lopogon, (C2.44) Rhizopogon fill vigieba, (C2.45) Pisolithus known as BIO-TAMTM) or in particular strain ICC080 tinctorius, (C2.46) Scleroderma cepa, (C2.47) Scleroderma (products known as Bioderma), (C2.109) Hirsutella citri citrinum, (C2.48) Sullins granulatus, (C2.49) Sullins punc formis, (C2.110) Muscodor roseus strain A3-5 (Accession US 2016/0286803 A1 Oct. 6, 2016

No. NRRL 30548), (C2.111) Neocosmospora vasinfecta, (C5.55) Phasmarhabditis hermaphrodita, (C5.56) Stein (C2.112) Penicillium vermiculatum (products known as Ver ernema bibionis, (C5.57) Steinernema glaseri (products miculenR), (C2.113) Saccharomyces cerevisae, in particular known as Biotopia), (C5.58) Steinernema kraussei (products strain CNCM No. I-3936, strain CNCM No. I-3937, strain known as Larvesure, Nemasys(R L), (C5.59) Steinernema CNCM No. I-3938, strain CNCM No. I-3939 (patent appli riobrave (products known as Biovector), (C5.60) Stein cation US 2011/0301030), (C2.114) Sporothrix insectorum ernema Scapterisci (products known asNematac S), (C5.61) (products known as Sporothrix.R.), Steinernema scarabaei, (C5.62) Steinernema siamkavai, 0092 (C3) Protozoas selected from the group consisting (C5.63) Beddingia (=Deladenus) Siridicola, (C5.64) Filipie of vimermis leipsandra, (C5.65) Steinernema thailandse prod 0093 (C3.1) Nosema locustae, (C3.2)Thelohania, (C3.3) ucts known as NemanoXCR), Vairimorpha: 0.098 (C6) Inoculants selected from the group consisting 0094 (C4) Viruses selected from the group consisting of of 0095 (C4.1) Gypsy moth (Lymantria dispar) nuclear 0099 (C6.1) Rhizobium leguminosarum, in particular bv. polyhedrosis virus (NPV), (C4.2) Tussock moth (Lymantrii viceae strain Z25 (Accession No. CECT 4585), (C6.2) dae) NPV. (C4.3) Heliothis NPV. (C4.4) Pine sawfly (Neo Rhizobium tropici, (C6.3) Rhizobium loti, (C6.4) Rhizobium diprion) NPV. (C4.5) Codling moth (Cydia pomonella) trifolii, (C6.5) Rhizobium meliloti, (C6.6) Rhizobium fredii, granulosis virus (GV), (C4.6) Adoxophyes Orana GV (prod (C6.7) Azorhizobium caulinodans, (C6.8) Pseudomonas, uct known as Capex.R.), (C4.7) Helicoverpa armigera NPV (C6.9) Azospirillum, (C6.10) Azotobacter, (C6.11) Strepto (products known as Vivus Max R, Vivus Gold(R) or Gem myces, (C6.12) Burkholdia, (C6.13) Agrobacterium, (C6.14) star R), (C4.8) Spodoptera exigua NPV. (C4.9) Spodoptera Endo Mycorhiza, (C6.15) Ecto Mycorhiza, (C6.16) Vesicu littoralis NPV. (C4.10) Spodoptera litura NPV. (C4.11) lar Arbuscular (VA) Mycorhiza, (C6.17) Bradyrhizobium, Neodiprion abietis NPV (product known as ABIETIVTM), 0100 (C7) Botanicals (or: plant extracts) selected from (C4.12) Neodiprion sertifer NPV (product known as Neo the group consisting of check-STM), (C4.13) Agrotis segetum (turnip moth) nuclear 0101 (C7.1) Thymus oil, (C7.2) Azadirachtin (Neem), polyhedrosis virus (NPV), (C4.14) Anticarsia gemmatalis (C7.3) Pyrethrum, (C7.4) Cassia nigricans, (C7.5) Quassia (Woolly pyrol moth) mNPV (products known as Poly gen), amara, (C7.6) Rotenon (C7.7) Garlic, (C7.8) Quillaja, (C4.15) Autographa Califomica (Alfalfa Looper) mNPV (C7.9) Sabadilla, in particular Veratrin, (C7.10) Ryania, in (products known as VPN80 from Agricola El Sol); particular Ryanodine, (C7.11) Viscum album (mistel), (C7. 0096 (C5) entomopathogenic nematodes selected from 12) mugwort or common tansy (Tanacetum vulgare), (C7. the group consisting of 13) Artemisia absinthium, (C7.14) Urtica dioica, (C7.15) 0097 (C5.1) Steinernema ssp. (=Neoaplectana spp.), Symphytum officinale, (C7.16) Tropaeulum majus, (C7.17) (C5.2) Steinernema scapterisci, (C5.3) Steinernema feltiae Quercus (C7.18) mustard flour, (C7.19) Chenopodium (Neoplectana carpocapsae, products known as Nema anthelminticum, (C7.20) Dryopteris filix-mas, (C7.21) bark syS(R), (C5.4) Steinernema carpocapsae (products known as of Chinese bittersweet (Celastrus orbiculatus), (C7.22) Biocontrol; Nematac R. C), (C5.5) Heterorhabditis spp., Equisetum arvense, (C7.23) bark of Celastus angulatus, (C5.6) Heterorhabditis heliothidis, (C5.7) Hexamermis spp., (C7.24) Laminarin (Brown Algae), (C7.25) Alginic acid (C5.8) Amphimermis spp., (C5.9) Mennis nigrescens, (C5. (Brown Algae), (C7.26) Chitin/Chitinosan. (C7.27) Che 10) Agamermis decaudata, (C5.11) Maupasina weissi, (C5. nopodium quinoa (product known as HeadsUp), (C7.28) 12) Subulura spp., (C5.13) Seuratum cadarachense, (C5.14) Melaleuca alternifolia (products known as Timorex Gold(R). Pterygodermatites spp., (C5.15) Abbreviata caucasica, (C5. (C7.29) Sesame oil (product known as Dragongfire 16) Spirura guianensis, (C5.17) Diplotriaena spp., (C5.18) CCPTM) and (C7.30) natural extracts or simulated blend of Tetrameres spp., (C5.19) Acuaria spp., (C5.20) Gongylon Chenopodium ambrosioides (products known as Requiem). ema spp., (C5.21) Protrellatus spp., (C5.22) Hydromermis 0102 (C8) Products produced by microorganisms includ spp., (C5.23) Cameronia spp., (C5.24) Physaloptera spp., ing proteins or secondary metabolites selected from the (C5.25) Chitwoodiella ovofilamenta, (C5.26) Gynopoecilia group consisting of pseudovipara, (C5.27) Parasity lenchus spp., (C5.28) 0103 (C8.1) Harpin (produced by Erwinia amylovora, Neoparasity len-chus rugulosi, (C5.29) Sulphuretvlenchus products known as Harp-N-TekTM, Messenger(R), EmployTM elongatus, (C5.30) Sphaerulariopsis spp., (C5.31) Allan ProActTM). Bacillus subtilis, for example the strains GBO3 tonema spp., (C5.32) Contorty lenchus spp., (C5.33) Bovi and QST 713, as well as Bacillus amyloliquefaciens, strain enema spp., (C5.34) Parasitaphelenchus spp., (C5.35) FZB 24 and 42, are species with phytopathogenic properties. Parasitorhabditis spp., (C5.36) Phasmarhabditis hermaph These bacteria are applied to the soil or to the leaves. rodita, (C5.37) Romanomermis spp., (C5.38) Octomyomer Bacillus thuringiensis with its different subspecies produces mis spp., (C5.39) Strelkovimermis peterseni, (C5.40) endotoxin containing crystals which have high insect patho Perutilimermis culicis, (C5.41) Culicinermis spp., (C5.42) genic specifity. Bacillus thuringiensis Subsp. kurStaki, strain Empidomermis spp., (C5.43) Gastromermis spp., (C5.44) HD-1, is used for control of lepidopteran larvae, but without Isomermis spp., (C5.45) Neonesomermis spp., (C5.46) Lim noctuidae. Bacillus thuringiensis Subsp. aizawai, for nomermis spp., (C5.47) Mesomermis spp., (C5.48) Xeno example the strains SAN 401 I, ABG-6305 and ABG-6346, rhabdus luminescence (entomopathogenic bacteria symbi is effective against different lepidopteran species including otically associated with nematodes); (C5.49) also noctuidae. Bacillus thuringiensis Subsp. tenebrionis, for Heterorhabditis bacteriophora (products known as example the strains SAN 418 I and ABG-6479, protects B-Green, Nemasys(RG), (C5.50) Heterorhabditis baujardi, plants against leaf beetle larvae. Bacillus thuringiensis (C5.51) Heterorhabditis indica (products known as Nema subsp. israelensis, for example the strains SAN 402 I and ton), (C5.52) Heterorhabditis marelatus, (C5.53) Heter ABG-6164, is applied against larvae of various dipteran orhabditis megidis, (C5.54) Heterorhabditis zealandica, pests, e.g. mosquitoes and nematoceres. US 2016/0286803 A1 Oct. 6, 2016

0104 Preference is given to combinations comprising at I0121 Preference is given to combinations comprising least (A) Fluopyram and (B3) Bacillus amyloliquefaciens strain 0105 (A) Fluopyram and (B1) Bacillus firmus strain IN937a, and (C) the biological control agent, with the CNCM 1-1582 and (C) the biological control agent, with the proviso that the spore-forming bacterium (B) of the genera proviso that the spore-forming bacterium (B) of the genera Bacillus and the biological control agent (C) are not iden Bacillus and the biological control agent (C) are not iden tical. tical. 0.122 Preference is given to combinations comprising 0106 Preference is given to combinations comprising at (A) Fluopyram and (B4) Bacillus amyloliquefaciens strain least FZB42 and (C) the biological control agent, with the proviso 0107 (A) Fluopyram and (B2) Bacillus cereus strain that the spore-forming bacterium (B) of the genera Bacillus CNCMI-1562 and (C) the biological control agent, with the and the biological control agent (C) are not identical. proviso that the spore-forming bacterium (B) of the genera I0123 Preference is given to combinations comprising Bacillus and the biological control agent (C) are not iden (A) Fluopyram and (B5) Bacillus subtilis strain GB03 and tical. (C) the biological control agent, with the proviso that the 0108 Preference is given to combinations comprising at spore-forming bacterium (B) of the genera Bacillus and the least biological control agent (C) are not identical. 0109 (A) Fluopyram and (B3) Bacillus amyloliquefa 0.124 Preference is given to combinations comprising ciens strain IN937a, and (C) the biological control agent, (A) Fluopyram and (B6) Bacillus subtilis strain QST713 and with the proviso that the spore-forming bacterium (B) of the (C) the biological control agent, with the proviso that the genera Bacillus and the biological control agent (C) are not spore-forming bacterium (B) of the genera Bacillus and the identical. biological control agent (C) are not identical. 0.125 Preference is given to combinations comprising 0110 Preference is given to combinations comprising at (A) Fluopyram and (B7) Bacillus pumilus strain GB34 and least (C) the biological control agent, with the proviso that the 0111 (A) Fluopyram and (B4) Bacillus amyloliquefa spore-forming bacterium (B) of the genera Bacillus and the ciens strain FZB42 and (C) the biological control agent, with biological control agent (C) are not identical. the proviso that the spore-forming bacterium (B) of the 0.126 Preference is given to combinations comprising genera Bacillus and the biological control agent (C) are not Fluopyram and (B8) Bacillus pumilus strain QST2808 and identical. (C) the biological control agent, with the proviso that the 0112 Preference is given to combinations comprising at spore-forming bacterium (B) of the genera Bacillus and the least biological control agent (C) are not identical. 0113 (A) Fluopyram and (B5) Bacillus subtilis strain I0127 Preference is given to combinations comprising GB03 and (C) the biological control agent, with the proviso (A) Fluopyram and the (B1) Bacillus firmus strain CNCM that the spore-forming bacterium (B) of the genera Bacillus I-1582 and one biological control agent selected from group and the biological control agent (C) are not identical. (C1) bacteria as described above with the proviso that the 0114 Preference is given to combinations comprising at spore-forming bacterium (B) of the genera Bacillus and the least biological control agent (C) are not identical. 0115 (A) Fluopyram and (B6) Bacillus subtilis strain I0128 Preference is given to combinations comprising QST713 and (C) the biological control agent, with the (A) Fluopyram and the (B2) Bacillus cereus strain CNCM proviso that the spore-forming bacterium (B) of the genera I-1562 and one biological control agent selected from (C1) Bacillus and the biological control agent (C) are not iden bacteria as described above with the proviso that the spore tical. forming bacterium (B) of the genera Bacillus and the 0116 Preference is given to combinations comprising at biological control agent (C) are not identical. Preference is least (A) Fluopyram and (B7) Bacillus pumilus strain GB34 given to combinations comprising (A) Fluopyram and the and (C) the biological control agent, with the proviso that the (B3) Bacillus amyloliquefaciens strain IN937a, and one spore-forming bacterium (B) of the genera Bacillus and the biological control agent selected from (C1) bacteria as biological control agent (C) are not identical. described above, with the proviso that the spore-forming 0117 Preference is given to combinations comprising at bacterium (B) of the genera Bacillus and the biological least control agent (C) are not identical with the proviso that the 0118 (A) Fluopyram and (B8) Bacillus pumilus strain spore-forming bacterium (B) of the genera Bacillus and the QST2808 and (C) the biological control agent, with the biological control agent (C) are not identical. proviso that the spore-forming bacterium (B) of the I0129. Preference is given to combinations comprising genera Bacillus and the biological control agent (C) are (A) Fluopyram and the (B4) Bacillus amyloliquefaciens not identical. strain FZB42 and one biological control agent selected from 0119 Preference is given to combinations comprising (C1) bacteria as described above, with the proviso that the (A) Fluopyram and (B1) Bacillus firmus strain CNCM spore-forming bacterium (B) of the genera Bacillus and the I-1582 and (C) the biological control agent, with the proviso biological control agent (C) are not identical with the that the spore-forming bacterium (B) of the genera Bacillus proviso that the spore-forming bacterium (B) of the genera and the biological control agent (C) are not identical. Bacillus and the biological control agent (C) are not iden 0120 Preference is given to combinations comprising tical. (A) Fluopyram and (B2) Bacillus cereus strain CNCM 0.130 Preference is given to combinations comprising I-1562 and (C) the biological control agent, with the proviso (A) Fluopyram and the (B5) Bacillus subtilis strain GB03 that the spore-forming bacterium (B) of the genera Bacillus and one biological control agent selected from (C1) bacteria and the biological control agent (C) are not identical. as described above, with the proviso that the spore-forming US 2016/0286803 A1 Oct. 6, 2016 bacterium (B) of the genera Bacillus and the biological 0147 Preference is given to combinations comprising at control agent (C) are not identical with the proviso that the least spore-forming bacterium (B) of the genera Bacillus and the 0148 (A) Fluopyram and the (B1) Bacillus firmus strain biological control agent (C) are not identical. Preference is CNCM I-1582 and one biological control agent selected given to combinations comprising (A) Fluopyram and the from (C3) protozoas as described above. (B6) Bacillus subtilis strain QST713 and one biological 0149 Preference is given to combinations comprising at control agent selected from (C1) bacteria as described least above, with the proviso that the spore-forming bacterium (B) of the genera Bacillus and the biological control agent 0150 (A) Fluopyram and the (B2) Bacillus cereus strain (C) are not identical. Preference is given to combinations CNCM I-1562 and one biological control agent selected comprising (A) Fluopyram and the (B7) Bacillus pumilus from (C3) protozoas as described above. strain GB34 and one biological control agent selected from 0151. Preference is given to combinations comprising at (C1) bacteria as described above, with the proviso that the least spore-forming bacterium (B) of the genera Bacillus and the 0152 (A) Fluopyram and the (B3) Bacillus amylolique biological control agent (C) are not identical. Preference is faciens strain 1N937a, and one biological control agent given to combinations comprising Fluopyram and the (B8) selected from (C3) protozoas as described above. Bacillus pumilus strain QST2808 and one biological control 0153. Preference is given to combinations comprising at agent selected from (C1) bacteria as described above, with least the proviso that the spore-forming bacterium (B) of the 0154 (A) Fluopyram and the (B4) Bacillus amylolique genera Bacillus and the biological control agent (C) are not faciens strain FZB42 and one biological control agent identical. selected from (C3) protozoas as described above. 0131 Preference is given to combinations comprising at 0155 Preference is given to combinations comprising at least least 0132 (A) Fluopyram and the (B1) Bacillus firmus strain 0156 (A) Fluopyram and the (B5) Bacillus subtilis strain CNCM I-1582 and one biological control agent selected GB03 and one biological control agent selected from (C3) from (C2) fungi or yeasts as described above. protoZoas as described above. 0.133 Preference is given to combinations comprising at 0157 Preference is given to combinations comprising at least least 0134) (A) Fluopyram and the (B2) Bacillus cereus strain 0158 (A) Fluopyram and the (B6) Bacillus subtilis strain CNCM I-1562 and one biological control agent selected QST713 and one biological control agent selected from (C3) from (C2) fungi or yeasts as described above. protoZoas as described above. 0135 Preference is given to combinations comprising at 0159 Preference is given to combinations comprising at least least 0.136 (A) Fluopyram and the (B3) Bacillus amylolique 0160 (A) Fluopyram and the (B7) Bacillus pumilus strain faciens strain IN937a, and one biological control agent GB34 and one biological control agent selected from (C3) selected from (C2) fungi or yeasts as described above. protoZoas as described above. 0.137 Preference is given to combinations comprising at 0.161 Preference is given to combinations comprising at least least 0138 (A) Fluopyram and the (B4) Bacillus amylolique 0162 (A) Fluopyram and the (B8) Bacillus pumilus faciens strain FZB42 and one biological control agent strain QST2808 and one biological control agent selected from (C2) fungi or yeasts as described above. selected from (C3) protozoas as described above. 0139 Preference is given to combinations comprising at 0163 Preference is given to combinations comprising at least least 0140 (A) Fluopyram and the (B5) Bacillus subtilis strain 0164 (A) Fluopyram and the (B1) Bacillus firmus strain GB03 and one biological control agent selected from (C2) CNCM I-1582 and one biological control agent selected fungi or yeasts as described above. from (C4) viruses as described above. 0141 Preference is given to combinations comprising at 0.165 Preference is given to combinations comprising at least least 0142 (A) Fluopyram and the (B6) Bacillus subtilis strain 0166 (A) Fluopyram and the (B2) Bacillus cereus strain QST713 and one biological control agent selected from (C2) CNCM I-1562 and one biological control agent selected fungi or yeasts as described above. from (C4) viruses as described above. 0143 Preference is given to combinations comprising at 0.167 Preference is given to combinations comprising at least least 0144 (A) Fluopyram and the (B7) Bacillus pumilus strain 0168 (A) Fluopyram and the (B3) Bacillus amylolique GB34 and one biological control agent selected from (C2) faciens strain IN937a, and one biological control agent fungi or yeasts as described above. selected from (C4) viruses as described above. 0145 Preference is given to combinations comprising at 0169 Preference is given to combinations comprising at least least 0146 (A) Fluopyram and the (B8) Bacillus pumilus 0170 (A) Fluopyram and the (B4) Bacillus amylolique strain QST2808 and one biological control agent faciens strain FZB42 and one biological control agent selected from (C2) fungi or yeasts as described above. selected from (C4) viruses as described above. US 2016/0286803 A1 Oct. 6, 2016

0171 Preference is given to combinations comprising at 0.195 Preference is given to combinations comprising at least least 0172 (A) Fluopyram and the (B5) Bacillus subtilis strain 0.196 (A) Fluopyram and the (B1) Bacillus firmus strain GB03 and one biological control agent selected from (C4) CNCM I-1582 and one biological control agent selected viruses as described above. from (C6) inoculants as described above. 0173 Preference is given to combinations comprising at 0.197 Preference is given to combinations comprising at least least 0.174 (A) Fluopyram and the (B6) Bacillus subtilis strain QST713 and one biological control agent selected from (C4) 0198 (A) Fluopyram and the (B2) Bacillus cereus strain viruses as described above. CNCM I-1562 and one biological control agent selected 0175 Preference is given to combinations comprising at from (C6) inoculants as described above. least 0199 Preference is given to combinations comprising at 0176 (A) Fluopyram and the (B7) Bacillus pumilus least strain GB34 and one biological control agent selected 0200 (A) Fluopyram and the (B3) Bacillus amylolique from (C4) viruses as described above. faciens strain IN937a, and one biological control agent 0177 Preference is given to combinations comprising at selected from (C6) inoculants as described above. least 0201 Preference is given to combinations comprising at 0.178 (A) Fluopyram and the (B8) Bacillus pumilus strain least QST2808 and one biological control agent selected from 0202 (A) Fluopyram and the (B4) Bacillus amylolique (C4) viruses as described above. faciens strain FZB42 and one biological control agent 0179 Preference is given to combinations comprising at selected from (C6) inoculants as described above. least 0203 Preference is given to combinations comprising at 0180 (A) Fluopyram and the (B1) Bacillus firmus strain least CNCM I-1582 and one biological control agent selected 0204 (A) Fluopyram and the (B5) Bacillus subtilis strain from (C5) entomopathogenic nematodes as described above. GB03 and one biological control agent selected from (C6) 0181 Preference is given to combinations comprising at inoculants as described above. least 0182 (A) Fluopyram and the (B2) Bacillus cereus strain 0205 Preference is given to combinations comprising at CNCM I-1562 and one biological control agent selected least from (C5) entomopathogenic nematodes as described above. 0206 (A) Fluopyram and the (B6) Bacillus subtilis strain 0183 Preference is given to combinations comprising at QST713 and one biological control agent selected from (C6) least inoculants as described above. 0184 (A) Fluopyram and the (B3) Bacillus amylolique 0207 Preference is given to combinations comprising at faciens strain IN937a, and one biological control agent least selected from (C5) entomopathogenic nematodes as 0208 (A) Fluopyram and the (B7) Bacillus pumilus strain described above. GB34 and one biological control agent selected from (C6) 0185. Preference is given to combinations comprising at inoculants as described above. least 0209 Preference is given to combinations comprising at 0186 (A) Fluopyram and the (B4) Bacillus amylolique least faciens strain FZB42 and one biological control agent 0210 (A) Fluopyram and the (B8) Bacillus pumilus selected from (C5) entomopathogenic nematodes as strain QST2808 and one biological control agent described above. selected from (C6) inoculants as described above. 0187 Preference is given to combinations comprising at 0211 Preference is given to combinations comprising at least least 0188 (A) Fluopyram and the (B5) Bacillus subtilis strain 0212 (A) Fluopyram and the (B1) Bacillus firmus strain GB03 and one biological control agent selected from (C5) CNCM I-1582 and one biological control agent selected entomopathogenic nematodes as described above. from (C7) botanicals as described above. 0189 Preference is given to combinations comprising at least 0213 Preference is given to combinations comprising at least 0.190 (A) Fluopyram and the (B6) Bacillus subtilis strain QST713 and one biological control agent selected from (C5) 0214 (A) Fluopyram and the (B2) Bacillus cereus strain entomopathogenic nematodes as described above. CNCM I-1562 and one biological control agent selected 0191 Preference is given to combinations comprising at from (C7) botanicals as described above. least 0215 Preference is given to combinations comprising at 0.192 (A) Fluopyram and the (B7) Bacillus pumilus strain least GB34 and one biological control agent selected from (C5) 0216 (A) Fluopyram and the (B3) Bacillus amylolique entomopathogenic nematodes as described above. faciens strain IN937a, and one biological control agent 0193 Preference is given to combinations comprising at selected from (C7) botanicals as described above. least 0217 Preference is given to combinations comprising at 0194 (A) Fluopyram and the (B8) Bacillus pumilus least strain QST2808 and one biological control agent 0218 (A) Fluopyram and the (B4) Bacillus amylolique Selected from (C5) entomopathogenic nematodes as faciens strain FZB42 and one biological control agent described above. selected from (C7) botanicals as described above. US 2016/0286803 A1 Oct. 6, 2016

0219) Preference is given to combinations comprising at 0241 Preference is given to combinations comprising at least least 0220 (A) Fluopyram and the (B5) Bacillus subtilis strain 0242 (A) Fluopyram and the (B8) Bacillus pumilus strain GB03 and one biological control agent selected from (C7) QST2808 and one biological control agent selected from botanicals as described above. (C8.1) Harpin (produced by Erwinia amylovora) as 0221 Preference is given to combinations comprising at described above. least 0243 (C5) entomopathogenic nematodes, 0222 (A) Fluopyram and the (B6) Bacillus subtilis strain 0244 (C6) inoculants, QST713 and one biological control agent selected from (C7) 0245 (C7) botanicals, and (C8.1) Harpin (produced by botanicals as described above. Erwinia amylovora) 0223 Preference is given to combinations comprising at least 0224 (A) Fluopyram and the (B7) Bacillus pumilus strain GB34 and one biological control agent selected from (C7) botanicals as described above. 0225 Preference is given to combinations comprising at least 0226 (A) Fluopyram and the (B8) Bacillus pumilus strain QST2808 and one biological control agent selected from (C7) botanicals as described above. 0227 Preference is given to combinations comprising at least 0228 (A) Fluopyram and the (B1) Bacillus firmus strain CNCM I-1582 and one biological control agent selected from (C8.1) Harpin (produced by Erwinia amylovora) as described above. 0229. Preference is given to combinations comprising at least 0230 (A) Fluopyram and the (B2) Bacillus cereus strain CNCM I-1562 and one biological control agent selected from (C8.1) Harpin (produced by Erwinia amylovora) as described above. 0231 Preference is given to combinations comprising at least 0232 (A) Fluopyram and the (B3) Bacillus amylolique faciens strain IN937a, and one biological control agent selected from (C8.1) Harpin (produced by Erwinia amylo vora) as described above. 0233 Preference is given to combinations comprising at least 0234 (A) Fluopyram and the (B4) Bacillus amylolique faciens strain FZB42 and one biological control agent selected from (C8.1) Harpin (produced by Erwinia amylo vora) as described above. 0235 Preference is given to combinations comprising at least 0236 (A) Fluopyram and the (B5) Bacillus subtilis strain GB03 and one biological control agent selected from (C8.1) Harpin (produced by Erwinia amylovora) as described above. 0237) Preference is given to combinations comprising at least 0238 (A) Fluopyram and the (B6) Bacillus subtilis strain QST713 and one biological control agent selected from (C8.1) Harpin (produced by Erwinia amylovora) as described above. 0239 Preference is given to combinations comprising at least 0240 (A) Fluopyram and the (B7) Bacillus pumilus strain GB34 and one biological control agent selected from (C8.1) Harpin (produced by Erwinia amylovora) as described above.

US 2016/0286803 A1 Oct. 6, 2016

losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens comprising the step of simul taneously or sequentially applying compound (A), spore forming bacteria (B) and at least one biological control agent (C) selected from bacteria, in particular spore-forming bac teria, fungi or yeasts, protoZoas, viruses, and entomopatho genic nematodes, inoculants botanicals, and products pro duced by microorganisms including proteins or secondary metabolites, particularly (C8.1) Harpin, on the plant, plant parts, harvested fruits or vegetables. 0266. As already mentioned before, using compound (A), spore-forming bacteria (B) and at least one biological con trol agent (C) selected from bacteria, in particular spore forming bacteria, fungi or yeasts, protoZoas, viruses, and entomopathogenic nematodes, inoculants, botanicals, and products produced by microorganisms including proteins or secondary metabolites, particularly (C8.1) Harpin as a com bination is advantageous. The broadening of the activity spectrum to other agricultural pests (i.e. insects, acari, nematodes, and phytopathogens) and, for example to resis tant strains of such agricultural pests or plant diseases can be achieved. 0267 Also according to the invention, the compound (A) Fluopyram, (B) a spore-forming bacterium of the genera Bacillus, selected from Bacillus firmus, Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, Bacillus subtilis strain QST713, and (C) a biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, ento mopathogenic nematodes, inoculants, botanicals and prod ucts produced by microorganisms including proteins or secondary metabolites, particularly (C8.1) Harpin can be used in a lower application rate and still achieve the suffi cient control of the agricultural pests or plant diseases. This is particularly visible if application rates for the before mentioned compounds or biological control agents are used where the individual compounds or biological control agents show no or virtually no activity. Moreover, even an enhanced systemic action of compound (A) Fluopyram, (B) a spore-forming bacterium of the genera Bacillus, selected from Bacillus firmus, Bacillus firma CNCMI-1582, Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacil lus subtilis strain GB03, Bacillus subtilis strain QST713, and (C) a biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microor ganisms including proteins or secondary metabolites, par ticularly (C8.1) Harpin is higher or a persistency of the fungicidal, insecticidal, acaricidal or nematicidal action is expected. 0264. The invention is further directed to the preparation 0268 Plant Physiology Effects of a composition containing compound (A), spore-forming 0269. Also according to the invention, the compound (A) bacteria (B) and at least one biological control agent (C) Fluopyram, (B) a spore-forming bacterium of the genera selected from bacteria, in particular sporeforming bacteria, Bacillus, selected from Bacillus firmus, Bacillus firma fungi or yeasts, protoZoas, viruses, and entomopathogenic CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillus nematodes, inoculants, botanicals, and products produced by amyloliquefaciens, Bacillus subtilis strain GB03, Bacillus microorganisms including proteins or secondary metabolites subtilis strain QST713, and (C) a biological control agent, in particularly (C8.1) Harpin, for reducing overall damage of particular bacteria, fungi or yeasts, protozoa, viruses, ento plants and plant parts as well as losses in harvested fruits or mopathogenic nematodes, inoculants, botanicals and prod vegetables caused by insects, nematodes or phytopathogens. ucts produced by microorganisms including proteins or 0265. The invention is also directed to a method for secondary metabolites, particularly (C8.1) Harpin can be reducing overall damage of plants and plant parts as well as used for improving plant physiology effects. US 2016/0286803 A1 Oct. 6, 2016 22

0270. In context with the present invention plant physi 0282 Delayed senescence, comprising improvement of ology effects comprise the following: plant physiology which is manifested, for example, in a 0271 Abiotic stress tolerance, comprising temperature longer grain filling phase, leading to higher yield, a longer tolerance, drought tolerance and recovery after drought duration of green leaf colouration of the plant and thus stress, water use efficiency (correlating to reduced water comprising colour (greening), water content, dryness etc. consumption), flood tolerance, oZone stress and UV toler Accordingly, in the context of the present invention, it has ance, tolerance towards chemicals like heavy metals, salts, been found that the specific inventive application of the pesticides (safener) etc. active compound combination makes it possible to prolong 0272 Biotic stress tolerance, comprising increased fun the green leaf area duration, which delays the maturation gal resistance and increased resistance against nematodes, (senescence) of the plant. The main advantage to the farmer viruses and bacteria. In context with the present invention, is a longer grain filling phase leading to higher yield. There biotic stress tolerance preferably comprises increased fungal is also an advantage to the farmer on the basis of greater resistance and increased resistance against nematodes flexibility in the harvesting time. 0273 Increased plant vigor, comprising plant health/ 0283. Therein “sedimentation value' is a measure for plant quality and seed vigor, reduced stand failure, improved protein quality and describes according to Zeleny (Zeleny appearance, increased recovery, improved greening effect value) the degree of sedimentation of flour Suspended in a and improved photosynthetic efficiency. lactic acid solution during a standard time interval. This is 0274 Effects on plant hormones or functional enzymes. taken as a measure of the baking quality. Swelling of the 0275 Effects on growth regulators (promoters), compris gluten fraction of flour in lactic acid solution affects the rate ing earlier germination, better emergence, more developed of sedimentation of a flour Suspension. Both a higher gluten root system or improved root growth, increased ability of content and a better gluten quality give rise to slower tillering, more productive tillers, earlier flowering, increased sedimentation and higher Zeleny test values. The sedimen plant height or biomass, shorting of stems, improvements in tation value of flour depends on the wheat protein compo shoot growth, number of kernels/ear, number of ears/m, sition and is mostly correlated to the protein content, the number of stolons or number of flowers, enhanced harvest wheat hardness, and the Volume of pan and hearth loaves. A index, bigger leaves, less dead basal leaves, improved phyl stronger correlation between loaf volume and Zeleny sedi lotaxy, earlier maturation/earlier fruit fmish, homogenous mentation volume compared to SDS sedimentation volume riping, increased duration of grain filling, better fruit fmish, could be due to the protein content influencing both the bigger fruit/vegetable size, sprouting resistance and reduced volume and Zeleny value (Czech J. Food Sci. Vol. 21, No. lodging. 3: 91-96, 2000). 0276 Increased yield, referring to total biomass per hect 0284. Further the “falling number as mentioned herein is are, yield per hectare, kernel/fruit weight, seed size or a measure for the baking quality of cereals, especially of hectolitre weight as well as to increased product quality, wheat. The falling number test indicates that sprout damage comprising: may have occurred. It means that changes to the physical 0277 improved processability relating to size distribu properties of the starch portion of the wheat kernel has tion (kernel, fruit, etc.), homogenous riping, grain moisture, already happened. Therein, the falling number instrument better milling, better vinification, better brewing, increased analyzes viscosity by measuring the resistance of a flour and juice yield, harvestability, digestibility, sedimentation value, water paste to a falling plunger. The time (in seconds) for falling number, pod stability, Storage stability, improved this to happen is known as the falling number. The falling fiber length/strength/uniformity, increase of milk or meet number results are recorded as an index of enzyme activity quality of silage fed animals, adaption to cooking and frying: in a wheat or flour sample and results are expressed in time 0278 further comprising improved marketability relating as seconds. A high falling number (for example, above 300 to improved fruit/grain quality, size distribution (kernel, seconds) indicates minimal enzyme activity and sound qual fruit, etc.), increased storage/shelf-life, firmness/softness, ity wheat or flour. A low falling number (for example, below taste (aroma, texture, etc.), grade (size, shape, number of 250 seconds) indicates Substantial enzyme activity and berries, etc.), number of berries/fruits per bunch, crispness, sprout-damaged wheat or flour. freshness, coverage with wax, frequency of physiological (0285. The term “more developed root system” (“im disorders, colour, etc.; proved root growth refers to longer root system, deeper root 0279 further comprising increased desired ingredients growth, faster root growth, higher root dry/fresh weight, Such as e.g. protein content, fatty acids, oil content, oil higher root Volume, larger root Surface area, bigger root quality, aminoacid composition, Sugar content, acid content diameter, higher root stability, more root branching, higher (pH), Sugar/acid ratio (Brix), polyphenols, starch content, number of root hairs, or more root tips and can be measured nutritional quality, gluten content/index, energy content, by analyzing the root architecture with suitable methodolo taste, etc., gies and Image analysis programmes (e.g. WinRhizo). 0280 and further comprising decreased undesired ingre dients such as e.g. less mycotoxines, less aflatoxines, geo 0286 The term “crop water use efficiency” refers tech Smin level, phenolic aromas, lacchase, polyphenol oxidases nically to the mass of agriculture produce per unit water and peroxidases, nitrate content etc. consumed and economically to the value of product(s) 0281 Sustainable agriculture, comprising nutrient use produced per unit water Volume consumed and can e.g. be efficiency, especially nitrogen (N)-use efficiency, phos measured in terms of yield per ha, biomass of the plants, phours (P)-use efficiency, water use efficiency, improved thousand-kernel mass, and the number of ears per m2. transpiration, respiration or CO2 assimilation rate, better 0287. The term “nitrogen-use efficiency” refers techni nodulation, improved Ca-metabolism etc. cally to the mass of agriculture produce per unit nitrogen US 2016/0286803 A1 Oct. 6, 2016 consumed and economically to the value of product(s) composition can be applied to the seed, the plant or to produced per unit nitrogen consumed, reflecting uptake and harvested fruits and vegetables or to the soil wherein the utilization efficiency. plant is growing or wherein it is desired to grow. 0288. Improvement in greening/improved colour and 0294 The term “controlling stands for a reduction of the improved photosynthetic efficiency as well as the delay of damage on the plant or plant parts as well as losses in senescence can be measured with well-known techniques harvested fruits or vegetables caused by insects, nematodes Such as a Handy Pea System (Hansatech). Fv/Fm is a param or phytopathogens of at least 30%, preferably 50%, more eter widely used to indicate the maximum quantum effi preferably 60%, more preferably 75%, more preferably ciency of photosystem II (PSIT). This parameter is widely 80%, more preferably 90%, when compared to the untreated considered to be a selective indication of plant photosyn control. thetic performance with healthy samples typically achieving 0295). If not mentioned otherwise, the expression “com a maximum Fv/Fm value of approx. 0.85. Values lower than bination' stands for the various combinations of the com this will be observed if a sample has been exposed to some pound (A) Fluopyram, (B) a spore-forming bacterium of the type of biotic or abiotic stress factor which has reduced the genera Bacillus, selected from Bacillus firmus, Bacillus capacity for photochemical quenching of energy within firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis, PSII. Fv/Fm is presented as a ratio of variable fluorescence Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, (Fv) over the maximum fluorescence value (Fm). The Per Bacillus subtilis strain QST713, and (C) a biological control formance Index is essentially an indicator of sample vitality. agent, in particular bacteria, fungi or yeasts, protozoa, (See e.g. Advanced Techniques in Soil Microbiology, 2007, viruses, entomopathogenic nematodes, inoculants, botani 11, 319-341; Applied Soil Ecology, 2000, 15, 169-182.) cals and products produced by microorganisms including 0289. The improvement in greening/improved colour and proteins or secondary metabolites, particularly (C8.1) Har improved photosynthetic efficiency as well as the delay of pin in a solo-formulation, in a single “ready-mix' form, in senescence can also be assessed by measurement of the net a combined spray mixture composed from Soloformulations, photosynthetic rate (Pn), measurement of the chlorophyll Such as a "tank-mix', and especially in a combined use of content, e.g. by the pigment extraction method of Ziegler the single active ingredients when applied in a sequential and Ehle, measurement of the photochemical efficiency manner, i.e. one after the other within a reasonably short (Fv/Fm ratio), determination of shoot growth and final root period, such as a few hours or days, e.g. 2 hours to 7 days. or canopy biomass, determination of tiller density as well as The order of applying compound (A), spore-forming bacte of root mortality. ria (B) and at least one biological control agent (C) selected 0290. Within the context of the present invention prefer from bacteria, in particular spore-forming bacteria, fungi or ence is given to improving plant physiology effects which yeasts, protoZoas, viruses, and entomopathogenic nema are selected from the group comprising: enhanced root todes, inoculants, botanicals, and products produced by growth/more developed root system, improved to greening, microorganisms including proteins or secondary metabo improved water use efficiency (correlating to reduced water lites, particularly (C8.1) Harpin is not essential for working consumption), improved nutrient use efficiency, comprising the present invention. especially improved nitrogen (N)-use efficiency, delayed 0296. Accordingly, the term “combination' also encom senescence and enhanced yield. passes the presence of the compound (A) Fluopyram, (B) a 0291. Within the enhancement of yield preference is spore-forming bacterium of the genera Bacillus, selected given as to an improvement in the sedimentation value and from Bacillus firmus, Bacillus firmus CNCM I-1582, Bacil the falling number as well as to the improvement of the lus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, protein and Sugar content—especially with plants selected Bacillus subtilis strain GB03, Bacillus subtilis strain from the group of cereals (preferably wheat). QST713, and (C) a biological control agent, in particular 0292 Preferably the novel use of the fungicidal or nem bacteria, fungi or yeasts, protozoa, viruses, entomopatho aticidal or pestidical compositions of the present invention genic nematodes, inoculants, botanicals and products pro relates to a combined use of a) preventively or curatively duced by microorganisms including proteins or secondary controlling insects, nematodes or phytopathogens, and b) at metabolites, particularly (C8.1) Harpin on or in a plant to be least one of enhanced root growth, improved greening, treated or its surrounding, habitat or storage space, e.g. after improved water use efficiency, delayed senescence and simultaneously or consecutively applying compound (A) enhanced yield. From group b) enhancement of root system, Fluopyram, (B) a spore-forming bacterium of the genera water use efficiency and N-use efficiency is particularly Bacillus, selected from Bacillus firmus, Bacillus firmus preferred. CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillus 0293. The compound (A) Fluopyram, (B) a spore-form amyloliquefaciens, Bacillus subtilis strain GB03, Bacillus ing bacterium of the genera Bacillus, selected from Bacillus subtilis strain QST713, and (C) a biological control agent, in firmus, Bacillus firmus CNCM I-1582, Bacillus cereus, particular bacteria, fungi or yeasts, protozoa, viruses, ento Bacillus pumilis, Bacillus amyloliquefaciens, Bacillus sub mopathogenic nematodes, inoculants, botanicals and prod tilis strain GB03, Bacillus subtilis strain QST713, and (C) a ucts produced by microorganisms including proteins or biological control agent, in particular bacteria, fungi or secondary metabolites, particularly (C8.1) Harpin to a plant yeasts, protozoa, viruses, entomopathogenic nematodes, its Surrounding, habitat or storage space. inoculants, botanicals and products produced by microor 0297. A solo- or combined-formulation is the formulation ganisms including proteins or secondary metabolites, par which is applied to the plants to be treated (e.g., in a ticularly (C8.1) Harpin may be applied in any desired greenhouse, on a field, in a wood), e.g., a tank formulation manner, such as in the form of a seed coating, soil drench, comprising the biological control agent in accordance with or directly in-furrow or as a foliar spray and applied either the present invention and a compound (A) or a liquid or Solid pre-emergence, post-emergence or both. In other words, the formulation comprising component (B) and the biological US 2016/0286803 A1 Oct. 6, 2016 24 control agent (C) which is applied prior, after or in parallel and various nematode species acquiring resistance to trans with a compound (A) to a plant to be treated. genic seed, nematode related crop losses appear to be on the 0298 If the compound (A) Fluopyram, (B) a spore rise. forming bacterium of the genera Bacillus, selected from 0303 Chemical nematicides such as soil fumigants or Bacillus firmus, Bacillus firmus CNCM I-1582, Bacillus non-fumigants have been in use for many years to combat cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacil nematode infestations. Such nematicides may require lus subtilis strain GB03, Bacillus subtilis strain QST713, and repeated applications of synthetic chemicals to the ground (C) a biological control agent, in particular bacteria, fungi or prior to planting. Due to their toxicity, chemical nematicides yeasts, protozoa, viruses, entomopathogenic nematodes, have come under scrutiny from the Environmental Protec inoculants, botanicals and products produced by microor tion Agency (EPA) and in some cases their use has been ganisms including proteins or secondary metabolites, par limited or restricted by the EPA. As the use of traditional ticularly (C8.1) Harpin are employed or used in a sequential chemical nematicides such as methyl-bromide and organo manner, it is preferred to treat the plants or plant parts phosphates continue to be phased out, a need for the (which includes seeds and plants emerging from the seed), development of alternative treatment options has arisen. harvested fruits and vegetables according to the following 0304. The term “plant to be treated encompasses every method: Firstly applying the compound (A) on the plant or part of a plant including its root system and the material plant parts, and secondly applying (B) the spore-forming —e.g., Soil or nutrition medium which is in a radius of at bacteria and (C) the biological control agent selected from least 10 cm, 20 cm, 30 cm around the bole of a plant to be bacteria, in particular spore-forming bacteria, fungi or treated or which is at least 10 cm, 20 cm, 30 cm around the yeasts, protoZoas, viruses, and entomopathogenic nema root system of said plant to be treated, respectively. todes, inoculant, botanicals and products produced by 0305 As already mentioned, the compound (A) Fluopy microorganisms including proteins or secondary metabo ram, (B) a spore-forming bacterium of the genera Bacillus, lites, particularly (C8.1) Harpin to the same plant or plant selected from Bacillus firmus, Bacillus firmus CNCM parts. The time periods between the first and the second I-1582, Bacillus cereus, Bacillus pumilis, Bacillus amyloliq application within a (crop) growing cycle may vary and uefaciens, Bacillus subtilis strain GB03, Bacillus subtilis depend on the effect to be achieved. For example, the first strain QST713, and (C) a biological control agent, in par application is done to prevent an infestation of the plant or ticular bacteria, fungi or yeasts, protozoa, viruses, ento plant parts with insects, nematodes or phytopathogens (this mopathogenic nematodes, inoculants, botanicals and prod is particularly the case when treating seeds) or to combat the ucts produced by microorganisms including proteins or infestation with insects, nematodes or phytopathogens (this secondary metabolites, particularly (C8.1) Harpin can be is parparticularly the case when treating plants and plant employed or used according to the invention as a solo- or a parts) and the second application is done to prevent or combined-formulation. Such formulations may include agri control the infestation with insects, nematodes or phyto culturally Suitable auxiliaries, solvents, carriers, Surfactants pathogens. Control in this context means that the biological or extenders. control agent is not able to fully exterminate the pests or 0306 If the active compounds in the active compound phytopathogenic fungi but is able to keep the infestation on combinations according to the invention are present in an acceptable level. certain weight ratios, the synergistic effect is particularly 0299. By following the before mentioned steps, a very pronounced. However, the weight ratios of the active com low level of residues of the compound (A) on the treated pounds in the active compound combinations can be varied plant, plant parts, and the harvested fruits and vegetables can within a relatively wide range. be achieved. (0307. In general, from 0.01 to 100 parts by weight, 0300. In general, the terms “spore-forming bacteria’, preferably from 0.05 to 20 parts by weight, particularly “fungi' or yeasts' comprise all stages of bacteria, fungi and preferably from 0.1 to 10 parts by weight, of active com yeast including resting spores, conidia, blastospores, fila pound of group (B) and from 0.01 to 100 parts by weight, mentous stages and other inactive forms of said organisms preferably from 0.05 to 20 parts by weight, particularly which can yield in active organisms. Thus, in one embodi preferably from 0.1 to 10 parts by weight, of active com ment, said organisms are comprised in form of spores in a pound of group (C) are present per part by weight of active formulation, e.g., a solo- or combined-formulation. compound (A) Fluopyram. The mixing ratio is preferably to 0301 In general, the term “nematode' comprises eggs, be chosen Such that a synergistic active compound combi larvae, juvenile and mature forms of said organism. Thus, in nation is obtained. one embodiment, said organisms are comprised in form of 0308 The weight ratio (A), (B) and (C) is selected as to eggs, larvae, juvenile or mature form in a formulation, e.g., give the desired, for example synergistic, action. In general, a solo- or combined-formulation. the weight ratio would vary depending on the specific active 0302 Nematodes are microscopic unsegmented worms compound. Generally the weight ratio between any of (A), known to reside in virtually every type of environment (B) and (C), independently of each other, is from 500 000:1 (terrestrial, freshwater, marine). Of the over 80,000 known to 1:500 000, preferably 200 000:1 to 1:200 000, more species many are agriculturally significant, particularly preferably, 100 000:1 to 1:100 000, and most preferably 50 those classified as pests. One Such species is the root knot OOO:1 to 1:50 OOO. nematode which attacks abroad range of plants, shrubs and 0309 Further weight ratio between any of (A), (B) and crops. These soil-born nematodes attack newly formed roots (C), independently of each other, which can be used accord causing stunted growth, Swelling or gall formation. The ing to the present invention with increasing preference in the roots may then crack open thus exposing the roots to other order given are 75 000:1 to 1:75 000, 25 000:1 to 1:25 000. microorganisms such as bacteria or fungi. With environmen 20 000:1 to 1:20 000, 10 000:1 to 1:10 000, 5000:1 to tally friendly practices such as reduced or no tillage farming, 1:5000, 2500:1 to 1:2500, 2000:1 to 1:2000, 1000:1 to US 2016/0286803 A1 Oct. 6, 2016

1:1000, 750:1 to 1:750, 500: 1 to 1:500, 250: 1 to 1:250, (A), compound (B) and the biological control agent (C), 200:1 to 1:200, 100:1 to 1:100, 95:1 to 1:95, 90:1 to 1:90, respectively, in a mono-formulation is known to the skilled 85:1 to 1:85, 8.0:1 to 1:80, 75:1 to 1:75, 70:1 to 1:70, 65:1 person. In one embodiment, the said ratio refer to the ratio to 1:65, 60:1 to 1:60, 55:1 to 1:55, 45:1 to 1:45, 40:1 to 1:40, of the three components after all three components, i.e 35:1 to 1:35, 30:1 to 1:30, 25:1 to 1:25, 15:1 to 1:15, 10:1 compound (A), compound (B) and the biological control to 1:10, 5:1 to 1:5, 4: 1 to 1:4, 3:1 to 1:3, 2:1 to 1:2. agent (C), respectively, were applied to a plant to be treated 0310. Further weight ratio between any of (A), (B) and independently whether the components were applied to a (C) are 1:200 000:20 000, 1:200 000:10 000. plant to be treated in form of solo-applications or in form of 0311. It has to be noted that before mentioned ratios a combined-formulation. ranges are based on a the spore preparation of the bacteria, 0315. It is preferred to employ or use the compound (A), fungi or yeasts which contains 10-10" spores (fungi or compound (B) and the biological control agent (C), and in bacteria) or cells (yeast or bacteria) per gram. If spore a synergistic weight ratio. The skilled person is able to find preparations vary in density, the ratios have to be adapted out the synergistic weight ratios for the present invention by accordingly to match the above listed ratio ranges. A ratio of routine methods. The skilled person understands that these 1:100 means 100 weight parts of the spore or cell prepara ratios refer to the ratio within a combined-formulation as tion of the fungi or yeast to 1 weight part of the compound well as to the calculative ratio of compound (A), compound (A). (B) and the biological control agent (C) described herein 0312 The amount of the biological control agent (C) when both components are applied as mono-formulations to selected from bacteria, in particular spore-forming bacteria, a plant to be treated. The skilled person can calculate this fungi or yeasts, protoZoas, viruses, and entomopathogenic ratio by simple mathematics since the Volume and the which is used or employed in combination with compound amount of compound (A), compound (B) and the biological (A) Fluopyram, (B) a spore-forming bacterium of the genera control agent (C), respectively, in a mono-formulation is Bacillus, selected from Bacillus firmus, Bacillus firmus known to the skilled person. In one embodiment, the said CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillus ratio refer to the ratio of the both components after all three amyloliquefaciens, Bacillus subtilis strain GB03, Bacillus components, i.e. compound (A), compound (B) and the subtilis strain QST713, and (C) a biological control agent, in biological control agent (C), respectively, were applied to a particular bacteria, fungi or yeasts, protozoa, viruses, ento plant to be treated independently whether the components mopathogenic nematodes, inoculants, botanicals and prod were applied to a plant to be treated in form of solo ucts produced by microorganisms including proteins or applications or in form of a combined-formulation. secondary metabolites, particularly (C8.1) Harpin, depends 0316. In one embodiment of the present invention, a on the final formulation as well as size or type of the plant, biological control agent (C) is a bacterium and the concen plant parts, seeds, harvested fruits and vegetables to be tration of the bacteria after dispersal is at least 50 g/ha, at treated. Usually, the biological control agent to be employed least 100 g/ha or at least 150 g/ha. or used according to the invention is present in about 2% to 0317. In one embodiment of the present invention, a about 80% (w/w), preferably in about 5% to about 75% biological control agent (C) is a bacterium, and the concen (w/w), more preferably about 10% to about 70% (w/w) of its tration of the bacteria after dispersal is at least 2.5 g/ha solo-formulation or combined-formulation with the com (hectare), such as 2.5-7500 g/ha, 5-2500 g/ha, 5-1500 g/ha; pound of formula (I), and optionally the inoculant. at least 250 g/ha; at least 100 g/ha, such as 100-5000 g/ha, 0313 If bacteria, fungi or yeasts are selected as biological 100-2500 g/ha, 100-1500 g/ha or 100-250 g/ha; or at least control agent, in particular those who are named as being 800 g/ha, such as 800-5000 g/ha or 800-2500 g/ha. preferred, it is preferred that they are present in a solo 0318. In another embodiment of the present invention, a formulation or the combined-formulation in a concentration biological control agent (C) is a bacterium, Such as B. firmus in excess of 10-10" cfu/g (colony forming units per gram), e.g., strain CNCM I-1582, and the concentration of the preferably in excess of 10°-10'cfu/g, more preferably 10'- bacteria after dispersal is at least 50 g/ha such as 50-5000 10" lcfu cfu/g and most preferably about 10 cfu/g. g/ha, 50-2500 g/ha, 50-200 g/ha; at least 100 g/ha, at least 0314. It is preferred to employ or use compound (A) 500 g/ha, at least 800 g/ha, such as 800-5000 g/ha or Fluopyram, (B) a spore-forming bacterium of the genera 800-2500 g/ha. Bacillus, selected from Bacillus firmus, Bacillus firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillus 0319. In another embodiment of the present invention, a amyloliquefaciens, Bacillus subtilis strain GB03, Bacillus biological control agent (C) is a bacterium, Such as B. subtilis strain QST713, and (C) a biological control agent, in subtilis, e.g., strain GB 03, and the concentration of the particular bacteria, fungi or yeasts, protozoa, viruses, ento bacteria after dispersal is at least 50 g/ha such as 50-5000 mopathogenic nematodes, inoculants, botanicals and prod g/ha, 50-2500 g/ha, 50-200 g/ha; at least 100 g/ha, at least ucts produced by microorganisms including proteins or 500 g/ha, at least 800 g/ha, such as 800-5000 g/ha or secondary metabolites, particularly (C8.1) Harpin in a syn 800-2500 g/ha. ergistic weight ratio. The skilled person is able to find out the 0320 In another embodiment of the present invention, a synergistic weight ratios for the present invention by routine biological control agent (C) is a bacterium, Such as B. methods. The skilled person understands that these ratios subtilis, e.g., strain QST713, and the concentration of the refer to the ratio within a combined-formulation as well as bacteria after dispersal is at least 50 g/ha such as 50-5000 to the calculative ratio of compound (A) Fluopyram and the g/ha, 50-2500 g/ha, 50-200 g/ha; at least 100 g/ha, at least biological control agent described herein when both com 500 g/ha, at least 800 g/ha, such as 800-5000 g/ha or ponents are applied as mono-formulations to a plant to be 800-2500 g/ha. treated. The skilled person can calculate this ratio by simple 0321. In another embodiment of the present invention, a mathematics since the Volume and the amount of compound biological control agent (C) is a bacterium, Such as B. US 2016/0286803 A1 Oct. 6, 2016 26 amyloliquefaciens and the concentration of the bacteria after rileyi) and compound (A) in a solo- or combined-formula dispersal is at least 500 g/ha, such as 500-5000 g/ha, tion or on or in a plant to be treated or its Surrounding, 500-2500 g/ha. habitat or storage space is between 50000:1 to 1:125, 0322. In one embodiment of the present invention, a between 25000:1 to 1:25 or even 500:1 to 1:5. biological control agent (C) is a fungus and the concentra 0331. In one embodiment of the present invention, the tion of the fungus after dispersal is at least 1 g/ha, Such as ratios between yeast (such as Metschnikowia fructicola) and 1-7500 g/ha, 1-2500 g/ha, 1-1500 g/ha; at least 250 g/ha compound (A) in a solo- or combined-formulation or on or (hectare), at least 500 g/ha or at least 800 g/ha. in a plant to be treated or its Surrounding, habitat or storage 0323. In one embodiment of the present invention, a space is between 2500:1 to 1:125, between 1250:1 and 1:125 biological control agent (C) is a fungus, such as Paecilo between 125:1 to 1:50, between 100:1 to 1:25 or even 50:1 myces lilacinus, e.g., Strain 251, and the concentration of the to 1:5. fungus after dispersal is at least 50 g/ha; at least 100 g/ha; 0332. In one embodiment of the present invention, the at least 1000 g/ha; at least 2500 g/ha, such as 2500-7500 ratios between nematodes (such as Steinernema feltiae and g/ha, 2500-6000 g/ha; or at least 4000 g/ha, such as 4000 Steinernema carpocapsae) and compound (A) in a solo- or 6000 g/ha. combined-formulation or on or in a plant to be treated or its 0324. In one embodiment of the present invention, a Surrounding, habitat or storage space is between 125:1 to biological control agent (C) is a fungus, such as Metarhizium 1:125, between 100:1 to 1:25 or even 50:1 to 1:5. anisopliae, e.g., Strain F52 and the concentration of the 0333. The application rate of the biological control agent fungus after dispersal is at least 1 g/ha, Such as 1-7500 g/ha, selected from bacteria, in particular spore-forming bacteria, 1-2500 g/ha, 1-250 g/ha; or at least 100 g/ha, such as 100 fungi or yeasts, protoZoas, viruses, entomopathogenic nema g/ha 1000 g/ha or 100-250 g/ha. todes, botanicals and products produced by microorganisms 0325 In one embodiment of the present invention, a including proteins or secondary metabolites, particularly biological control agent (C) is yeast, such as Metschnikowia (C8.1) Harpin to be employed or used according to the fructicola, and the concentration of the yeast after dispersal present invention may vary. The skilled person is able to find is at least 50 g/ha, such as 50-5000 g/ha, 50-2000 g/ha; at the appropriate application rate by way of routine experi least 1000 g/ha; at least 1500 g/ha, such as 500-5000 g/ha, mentS. 500-2500 g/ha, 500-2000 g/ha. 0334 Microorganisms such as fungi or bacteria can be 0326 In one embodiment of the present invention, a obtained by conventional fermentation processes. The fer biological control agent (C) is a virus and the concentration mentation can be carried out using solid, semi-solid or liquid of the virus after dispersal is at least 50 g/ha such as 50-7500 nutrient media. If spores such as conidia are used, preference g/ha, 50-2500 g/ha, 50-1500 g/ha; at least 100 g/ha or at least is given to Solid or semi-solid nutrient media. The nutrient 150 g/ha. media contain the nutrients suitable and known for the 0327. In one embodiment of the present invention, a cultivation of the respective microorganisms, in particular biological control agent (C) is a virus, such as Codling moth one or more metabolizable carbon sources or nitrogen (Cydia pomonella) granulosis virus and the concentration of Sources and mineral salts. The fermentation is generally the virus after dispersal is at least 50 g/ha (hectare) such as carried out at temperatures between about 3° and about 40° 50-5000 g/ha, 50-2500 g/ha, 50-1500 g/ha or 50-250 g/ha; or C., preferably between 20° and 35° C. For example, a at least 100g/ha, such as 100-500 g/ha or 100-250 g/ha. representative fermentation is described in U.S. Pat. No. 0328. In one embodiment of the present invention, a biological control agent (C) is an entomopathogenic nema 5,804,208. tode and the concentration of the nematodes is at least 10 0335 A fermentation process comprises in general the nematodes/ha, e.g., larval stage nematodes/ha, such as 10'- steps of a) incubating spores such as conidia of a microor 10' nematodes/ha, e.g., larval stage nematodes/ha, 10°-10' ganism in or on a nutrition medium (such as agar with nematodes/ha, e.g., larval stage nematodes/ha, at least 10 further additives such as oatmeal); b) separating spores Such nematodes/ha, e.g., larval stage nematodes/ha such as 10 as conidia from the nutrition medium after the incubation 10' nematodes/ha, e.g., larval stage nematodes/ha, 10-10' time, (e.g., by shake off the conidia from the medium, nematodes/ha, e.g., larval stage nematodes/ha; or at least 10 centrifuging, filtrating); and optionally c) preparing an emul nematodes/ha, e.g., larval stage nematodes/ha, such as 10'- sion of said isolated conidia. 10' nematodes/ha, e.g., larval stage nematodes/ha or 10'- 0336. The skilled person is well aware how to adapt 10' nematodes/ha, e.g., larval stage nematodes/ha. fermentation to a given microorganism Such as fungi or 0329. In one embodiment of the present invention, the bacteria. In the following, several fermentations are exem ratios between (B) a spore-forming bacterium of the genera plified in more detail. These examples are not meant to limit Bacillus, selected from Bacillus firmus, Bacillus firma the scope of the present invention. CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillus 0337 Bacteria amyloliquefaciens, Bacillus subtilis strain GB03, Bacillus 0338 Bacillus thuringiensis were cultured using media subtilis strain QST713 and compound (A) in a solo- or and fermentation techniques known in the art (see, for combined-formulation or on or in a plant to be treated or its example, Rogoff et al., 1969, J. invertebrate Path. 14: surrounding, habitat or storage space is between 500 000:1 122-129: Dulmage et al., 1971, J. Invertebrate Path. 18: to 1:500 000, preferably 200 000:1 to 1:200 000, more 353-358; Dulmage et al., in Microbial Control of Pests and preferably, 100 000:1 to 1:100 000, and most preferably 50 Plant Diseases, H. D. Burges, ed., Academic Press, N.Y., OOO:1 to 1:50 OOO. 1980). Upon completion of the fermentation cycle, the 0330. In one embodiment of the present invention, the Supernatant can be recovered by separating Bacillus ratios between fungi (such as Metarhizium anisopliae, thuringiensis spores and crystals from the fermentation Paecilomyces lilacinus, Beauveria bassiana, Nomuraea broth by means well known in the art, e.g., centrifugation US 2016/0286803 A1 Oct. 6, 2016 27 ultrafiltration, evaporation, or spray-drying (see also WO ria was grown in Landy medium as described in Koumoutsi 1996.001563 which is herewith incorpotated by refernce its et al., 2004. To prepare surface cultures, the strains were entirety). grown in petri dishes containing 1.5% Landy agar for 24h 0339. The following culturing of Bacillus thuringiensis is at 37° C. and stored at room temperature prior to MALDI e.g. exemplified in U.S. Pat. No. 5,508,032A, 1996: TOF-MS analysis. Fermentation in liquid media was carried 0340. A subculture of Bacillus thuringiensis isolates can out in flasks at 30° C. and 180 rpm in a shaker (Journal of be used to inoculate the following medium, a peptone, Bacteriology, February. 2004, p. 1084-1096). glucose, salts medium: Bacto Peptone 7.5 g/1 Glucose, 1.0 (0349 Fungi g/l KHPO, 3.4 g/l KHPO, 4.35 g/l salt solution, 5.0 ml/1 0350. The fungus Metarhizium anisopliae, strain DSM CaCl, solution, 5.0 ml/l salts solution (100 ml) MgSO 3884, is known from EP-A-0268177. The production of 7HO, 2.46 g MnSO-HO, 0.04 g ZnSO4-7HO, 0.28 g conidia of Metarhizium anisopliae is exemplified in EP FeSO-7H2O, 0.40 g CaCl, solution (100 ml), CaCl2.H2O, 0794704 B1 (U.S. Pat. No. 5,804,208). 3.66 g pH 7.2. 0351. A nutrition medium Such as oatmeal agar (e.g., 0341 The salts solution and CaCl, solution were steril composition: 30 g of oat flakes and 20g of agar) in a Petri ized (e.g., filter-sterilized) and added to the sterilized (e.g., dish was inoculated with, e.g., 3 week old conidia of the autoclaved and cooked) broth at the time of inoculation. Metarhizium anisopliae strain DSM 3884. The incubation Flasks were incubated at around 30°C. on a rotary shaker at time to multiply the conidia is, e.g., 3, 4, 5, or 6 days. The 200 rpm for 64 hours. The procedure can be readily scaled incubation temperature can be around 7° C. to around 40° up to large fermentors by procedures well known in the art. C., e.g. 22° to 25°C. The formed conidia was isolated by, The Bacillus thuringiensis spores and crystals, obtained in e.g., shaking off the conidia. The conidia can be stirred with the fermentation, can be isolated by procedures well known 50ml of water containing 1% of a non-ionic emulsifier such in the art. A frequently-used procedure is to Subject the as an emulsifier based on polyoxy-ethylene (20) sorbitan harvested fermentation broth to separation techniques, e.g., monolaurate (Tween 20R) until a suspension was obtained centrifugation. in which the conidia was present as isolated particles. The 0342. The bacterium Bacillus firmus conidia titer was and can be determined using, e.g., a 0343. The bacteria Bacillus subtilis is a naturally occur Neubauer chamber. The conidia can be stored in closed ring bacteria found in soils all over the world. Bacillus cases under dry conditions, preferably at temperatures subtilis strain QST713 was isolated in 1995 by AgraGuest between 0° and 25° C. Inc. from soil in a California peach orchard. This product is 0352 Paecilomyces lilacinus strain 251 was isolated applied to foliage (NYDEC 2001). In contrast, Bacillus from infected nematode eggs in the Philippines, and cor subtilis strain GB03 (Kodiak.R.) was discovered in Australia rectly described taxonomically in 1974. Optimal laboratory in the 1930's and is applied either as a seed treatment or growth of Paecilomyces lilacinus strain 251 occurs at 21-27 directly to soil. Neither strain is considered a genetically C., and does not grow or survive above 36° C. (U.S. modified organism (Cornell University: Organic Resource Environmental Protection Agency, P lilacinus strain 251 Guide, Material fact sheet Bacillus subtilis) Fact sheet). The following cultivation of Paecilomyces 0344 Isolation of Bacillus subtilis and related strains lilacinus is exemplified in Patent Application WO/1994/ from soil: To isolate wild Bacillus subtilis Strains, e.g., 2 g 025579 (1994): soil samples were dissolved in 2 ml of 10 mM Tris/HCl (pH 0353 Paecilomyces lilacinus (Thorn) Samson (CBS 143. 7.2) and then boiled at 95°C. for 5 min From these samples, 75), obtained e.g. from the CBS (Central Bureau of Fungal 0.1 ml of each sample was then spread onto LB plates and Cultures) in Baarn (The Netherlands), can be maintained on incubated at 37° C. Potato Dextrose Agar (PDA; Difco laboratories) at 25°C. A 0345 Sporulation assay: Bacillus subtilis strains were conidial Suspension was obtained by adding sterilized water grown in 26 SG medium at 37° C. and sporulation was (e.g., 5 ml) to a Petri dish containing sporulating mycelium assayed at 24 hours after the end of the exponential phase. and scraping the Surface with a glass rod. Liquid cultures The number of spores per ml culture was determined by were obtained by inoculating conidia of the fungus to identifying the number of heat-resistant colony forming minimal salt medium or corn flour medium Supplemented units (80° C. for 10 min) on LB plates. with the substrate. The minimal salt medium (MM) consists 0346 Bacillus subtilis, strain Marburg, was grown aero of 4.56 g H2PO4, 2.77 g KH2 HPO4, 0.5g MgSO4. 7H20 bically in heart infusion broth (Difco Laboratories, Detroit, and 0.5 g. KCl/l, pH 6.0. Mycelium can be obtained by Mich.) on shaker at about 37° C. From an overnight culture centrifuging a, e.g., 6 day old culture of conidia of Paeci 4 drops were inoculated into 70 ml of pre warmed broth. lomyces lilacinus. For example, cultures can be grown in a Growth was measured as optical density at 620 nm. Cells shaking water bath for several days at 30° C. and 125 strokes were collected after 3.5-4.5 hours in the exponential phase per minute. Culture filtrates were obtained by centrifuging of growth. Centrifugation was carried out at room tempera cultures for, e.g., 45 min at 9000 g. ture for 15 min at 7000 g (The Journal of Cell Biology. 0354. The preparation of Metschnikowia fructicola is Volume 48, 1971 pages 219-224). exemplified in U.S. Pat. No. 6,994,849: 0347 Bacillus subtilis is active in temperatures between 0355 The yeast species Metschnikowia fructicola was 7° C. and 45° C. isolated from the surface of grape berries (cv. Superior) 0348 Bacillus amyloliquefaciens strain FZB42, was grown in the central part of Israel. At various stages, originally isolated from infested soil in Germany (Krebs et individual berries were submersed in sterile distilled water al., 1998, Chen et al., 2007). Bacillus amyloliquefaciens in 100 ml beakers and shaken vigorously for 2 hours on strain FZB42 was cultivated in Luria broth (LB -1% w/v. rotary shaker at 120 rpm. Aliquots of 100 ml were removed peptone, 0.5% w/v yeast extract, 0.5% w/v NaCL) at 30° C. from the wash liquid and plated on PDA (Potato Dextrose (Journal of Biotechnology 151 (2011) 303-311). The bacte Agar; DIFCO Laboratories, U.S.A.) medium. Following 4-5 US 2016/0286803 A1 Oct. 6, 2016 28 days of incubation, yeast colonies were picked randomly can be held in the refrigerator (2-6° C.) until use for up to according to colony characteristics (color and morphology) 4 weeks and can be reactivated by Suspension in warm water and streaked individually on fresh medium to obtain bio (>12° C.). logically pure cultures. Cultures were further purified by repeated streaking on PDA. Identification and characteriza 0364 One method to isolate entomopathogenic nema tion of the new species was done at the Microbial Genomics todes from soil is described by Cairns, 1960, Folia para and Bioprocessing center, USDA-ARS, Peoria, Ill., USA. Sitica 47: 315-318, 2000. For soil samples, a sieving Metschnikowia fructicola was deposited at the NRRL under decanting method was employed with fimal isolation of the the number Y-30752. This deposit has been made in com nematodes from the sieving debris using a Baermann funnel pliance with the terms of the Budapest Treaty. with cotton filter. For this method, which is commonly applied for the extraction of plant-parasitic and Soil nema 0356 Metschnikowia fructicola was propagated under todes (Southey 1986), 250 ml soil was used. The nematode aerobic conditions at temperatures ranging from 5°C. to 37 Suspension was fixed, checked for the presence of ento C. Optimal growth temperature is between 20°C. and 27°C. mopathogenic nematodes using an inverted light micro The yeast grows in liquid medium (nutrient broth; Droby et Scope, and the number of Steinemema specimens was deter al., 1989) with a neutral pH. The cell density of the yeast mined. Species identification was mostly done at high generally reached its maximum (stationary stage) growth in microscopical magnification using morphological characters 24-48 hours. For laboratory and small scale tests growth in of the infective-stage juveniles (Sturhan in Hominick et al. Erlenmeyer flasks containing the medium and shaken on a 1997, and unpublished). rotary shaker was suitable. For large scale and commercial tests, fermentation tanks and industrial growth media were 0365 Entomopathogenic nematodes can be mass-pro preferred. The yeast cells were harvested by centrifugation duced by in-vivo or in-vitro methods. Larvae of Galleria using conventional laboratory or industrial centrifuges. mellonella are most commonly used to rear nematodes 0357 Viruses because of their commercial availability. Several researchers 0358 Cydia pomonella granulosis viruses (CpGV) which (Dutky et al. 1964, Howell 1979, Lindegren et al. 1993, Flanders et al. 1996) have described the methods of nema are used in the products MADEX (Andermatt Biocontrol) tode infection, inoculation, and harvesting Using the in-vivo and Granupom (Probis GmbH) are deposited since 2005 at process, yields between 0.5x10-4x10 infective juveniles, the German Collection of Microorganisms and Cell Cultures depending on the nematode species, have been obtained. (DSMZ). Isolates used for the production of MADEX (An During the past few years a distinct cottage industry has dermatt Biocontrol), Granupom (Probis GmbH), VIRGO emerged in the USA which utilizes the in-vivo process for (SipcamS.p.A.) and CARPOVIRUSINE (Arysta Life nematode mass-production for sale, especially in the home Science S.A.S) were all derived from the Mexican isolate lawn and garden markets. The in-vivo process, however, originally isolated in 1963 and are not genetically modified. lacks any economy of scale; the labor, equipment, and (Virus accession number: GV-0001) material (insect) costs increase as a linear function of 0359 The identity of the virus produce can be bioana production capacity. Perhaps even more important is the lack lytically checked against the parent strain by SDS-poly of improved quality while increasing scale. The in-vivo acryla-mide-gel electrophoresis of the virus protein sand by nematode production is increasingly sensitive to biological Restriction endonuclease analysis of viral DNA. variations and catastrophes as scale increases (Friedman 0360 Prior to DNA isolation the test item has to be 1990). Several formulations have been developed for the purified. The purified CpGV OB pellet is resuspended in 1 storage and application of entomopathogenic nematodes. ml sterile water and the CpGV OB concentration is enu The shelf life of different nematode-based products varies merated in the Petroff-Hausser counting chamber. The con depending on the formulation, nematode species and tem centration of active Cydia pomonella Granulosis virus perature. In the simplest type of formulation, the nematodes (CpGV) is determined by means of a quantitative bioassay. are impregnated onto moist carrier Substrates providing The granules (occlusion bodies) of CpGV are counted under Substantial interstitial spaces leading to increased gas the light microscope. The virus titer in the end-use product exchange. Such carriers include polyether polyurethane is adjusted to the requested granules/l (Assessment Report: sponge, cedar shavings, peat, Vermiculite, etc. Nematodes Cydia pomonella Granulovirus (CpGV)—Mexican Isolate held on the sponge need to be hand-squeezed into water (2007). before application, whereas from the other carriers they may 0361 CpGV derives from the Mexican isolate of CpGV be applied directly to the soil as mulch (Neotropical Ento (Tanada, 1964) and is propagated in larvae of Cydia pomo mology, vol.30, no.2, Londrina, June 2001, ISSN 1519 nella. Infected larvae are homogenized and centrifuged in 566X). 50% sucrose (w/w). The pellet is resuspended and the 0366. A bioassay to determine nematode viability is granules are purified by, e.g., centrifugation through a linear described, e.g., in Simser (J. of Nematology 24(3):374-378: 50% to 60% (w/w) sucrose gradient, generating a virus band 1992). The Nematode viability was verified by host bioas which is then repeatedly washed in Tris buffer and pelleted say. Late instar larvae of the greater wax moth, Galleria to remove residual Sucrose. (Journal of general Virology mellone, were buried 2.5 cm deep between plants before (1992), 73, 1621-1626). nematode application (four larvae per replicate), collected 0362 Entomopathogenic Nematodes after 7 days, placed in petri dishes (9 cm diameter) and held 0363 Nematodes can be reared in liquid culture tech in darkness at ca. 25 C. Insect mortality (>90%) and sub niques (see, e.g., U.S. Pat. No. 5,023,183 which is herewith sequent nematode propagation with cadavers demonstrated incorporated by reference in its entirety) and stored, for infectivity of the nematodes. The skilled person is well example, as eggs, larvae in Suspension cultures or in clay aware how to adopt this kind of bioassay to different powder or adult nematodes, e.g., in clay powder. Nematodes nematode species. US 2016/0286803 A1 Oct. 6, 2016 29

0367 The preferred application rate of bacteria as bio tine, coconut, cantaloupes and includes their harvested logical control agent, in particular of spores of the bacteria goods, such as fruits and vegetables. (1.26a), namely B. subtilis strain GBO3, lies in the range of 0373). It is further generally preferred to use or employ 0.1 to 3 kg/ha. the compound (A), compound (B) and the biological control 0368. The preferred application rate of fungi as biological agent (C) selected from bacteria, in particular spore-forming control agent, in particular the fungi Metarhizium anisopliae bacteria, fungi or yeasts, protoZoas, viruses, and ento strain F 52 lies in the range of 0.1 to 3 kg/ha mopathogenic nematodes, inoculants, botanicals and prod 0369. The preferred application rate of yeasts as biologi ucts produced by microorganisms including proteins or cal control agent, in particular the yeast Metschnikowia secondary metabolites, particularly (C8.1) Harpin on horti fructicola strain NRRLY-30752 lies in the range of 0.05 to cultural crops as well as broad acre crops such as cotton, 8 kg/ha. corn, soybean, cereals, canola, oil seed rape, sugar cane and 1Ce. 0370. The preferred application rate of protozoa, viruses, 0374 Furthermore the invention relates to a method of and entomopathogenic nematodes as biological control controlling insects, nematodes or phytopathogens, charac agents lies in the range of 0.5 to 10 kg/ha. terized in that the active compound combinations according 0371. It is generally preferred to use or employ the to the invention are applied to the insects, nematodes or compound (A), compound (B) and the biological control phytopathogens or their habitat. agent (C) selected from bacteria, in particular spore-forming 0375. If not mentioned otherwise the treatment of plants bacteria, fungi or yeasts, protoZoas, viruses, and ento or plant parts (which includes seeds and plants emerging mopathogenic nematodes inoculants, botanicals and prod from the seed), harvested fruits and vegetables with the ucts produced by microorganisms including proteins or compound (A) Fluopyram, (B) a spore-forming bacterium of secondary metabolites, particularly (C8.1) Harpin on horti the genera Bacillus, selected from Bacillus firmus, Bacillus cultural crops, such as cotton, flax, grapevines, fruit, Veg firmus CNCM I-1582, Bacillus cereus, Bacillus pumilis, etable, such as Rosaceae sp. (for example pomaceous fruit, Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, such as apples and pears, but also stone fruit, such as Bacillus subtilis strain QST713, and (C) a biological control apricots, cherries, almonds and peaches and soft fruit such as agent, in particular bacteria, fungi or yeasts, protozoa, strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae viruses, entomopathogenic nematodes, inoculants, botani sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., cals and products produced by microorganisms including Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae proteins or secondary metabolites, particularly (C8.1) Har sp. (for example banana trees and plantations), Rubiaceae pin is carried out directly or by action on their surroundings, sp. (for example coffee). Theaceae sp., Sterculiceae sp., habitat or storage space using customary treatment methods, Rutaceae sp. (for example lemons, oranges and grapefruit), for example dipping, spraying, atomizing, irrigating, evapo Solanaceae sp. (for example tomatoes), Liliaceae sp., Aster rating, dusting, fogging, broadcasting, foaming, painting, aceae sp. (for example lettuce), Umbelliferae sp., Cruciferae spreading-on, watering (drenching), drip irrigating. It is sp., Chenopodiaceae sp., Cucurbitaceae sp. (for example furthermore possible to apply compound (A) Fluopyram, cucumbers). Alliaceae sp. (for example leek, onions). Pap (B) a spore-forming bacterium of the genera Bacillus, illionaceae sp. (for example peas); major crop plants, such selected from Bacillus firmus, Bacillus firmus CNCM Gramineae sp. (for example maize, lawn, cereals such as I-1582, Bacillus cereus, Bacillus pumilis, Bacillus amyloliq wheat, rye, rice, barley, oats, millet and triticale). Poaceae uefaciens, Bacillus subtilis strain GB03, Bacillus subtilis sp. (for example sugarcane), Asteraceae sp. (for example strain QST713, and (C) a biological control agent, in par sunflowers), Brassicaceae sp. (for example white cabbage, ticular bacteria, fungi or yeasts, protozoa, Viruses, ento red cabbage, broccoli, cauliflowers, Brussels sprouts, pak mopathogenic nematodes, inoculants, botanicals and prod choi, turnip cabbage, garden radish, and also oilseed rape, ucts produced by microorganisms including proteins or mustard, horseradish and cress), Fabacae sp. (for example secondary metabolites, particularly (C8.1) Harpin as solo beans, peas, peanuts), Papilionaceae sp. (for example Soya formulation or combined-formulations by the ultra-low vol beans). Solanaceae sp. (for example potatoes), Chenopodi ume method, or to inject the compound (A) Fluopyram, (B) aceae sp. (for example sugar beet, fodder beet, Swiss chard, a spore-forming bacterium of the genera Bacillus, selected beetroot); crop plants and ornamental plants in garden and from Bacillus firmus, Bacillus firmus CNCM I-1582, Bacil forest; and also in each case genetically modified varieties of lus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, these plants. Bacillus subtilis strain GB03, Bacillus subtilis strain 0372 Horticultural crops particularly includes carrots, QST713, and (C) a biological control agent, in particular pumpkin, squash, Zucchini, potato, Sweet corn, onions, orna bacteria, fungi or yeasts, protozoa, viruses, entomopatho mentals, medicinal herbs, culinary herbs, tomatoes, spinach, genic nematodes, inoculants, botanicals and products pro pepper, melon, lettuce, cucumber, celery, beets, cabbage, duced by microorganisms including proteins or secondary cauliflower, broccoli, Brussels sprouts, turnip cabbage, kale, metabolites, particularly (C8.1) Harpin as a composition or radish, rutabaga, turnip, asparagus, bean, pea, apples, rasp as sole-formulations into the soil (in-furrow). berry, strawberry, banana, mango, grapes, peaches, pears, 0376 Compositions guava, pineapple, pomegranate, garlic, capsicum, chili, rad 0377 The present invention furthermore relates to com ish, star fruit, tapioca, walnuts, lemon, mandarin, mangold. positions for reducing overall damage of plants and plant mushroom, olive, orange, papaya, paprika, passion fruit, parts as well as losses in harvested fruits or vegetables peanuts, pecan nuts, prune, pistachio nuts, persimmon, pam caused by insects, nematodes or phytopathogens and which plemouse (grape-fruit), eggplant, endive, cranberry, goose have fungicidal or nematicidal or insecticidal activity berry, hazel nuts, kiwifruit, almonds, amaranth, apricot, including any combination of the three activities comprising artichoke, avocado, blackberry, cashew nut, cherry, clemen the active compound combinations according to the inven US 2016/0286803 A1 Oct. 6, 2016 30 tion. Preferably, the compositions are fungicidal or nemati 0384 The compositions according to the invention may cidal or insecticidal (including any combination of the three) comprise additional further components. Such as, for compositions comprising agriculturally suitable auxiliaries, example, Surfactants. Suitable surfactants are emulsifiers, Solvents, carriers, Surfactants or extenders. dispersants or wetting agents having ionic or nonionic 0378 For the sake of clearness, a combination means a properties, or mixtures of these surfactants. Examples of physical combination of (A) Fluopyram, (B) a spore-form these are salts of polyacrylic acid, salts of lignoSulphonic ing bacterium of the genera Bacillus, selected from Bacillus acid, salts of phenolsulphonic acid or naphthalenesulphonic firmus, Bacillus firmus CNCM I-1582, Bacillus cereus, acid, polycondensates of ethylene oxide with fatty alcohols Bacillus pumilis, Bacillus amyloliquefaciens, Bacillus sub or with fatty acids or with fatty amines, substituted phenols tilis strain GB03, Bacillus subtilis strain QST713, and (C) at (preferably alkylphenols or arylphenols), salts of Sulphosuc least one biological control agent, in particular bacteria, cinic esters, taurine derivatives (preferably alkyl taurates), fungi or yeasts, protozoa, viruses, entomopathogenic nema phosphoric esters of polyethoxylated alcohols or phenols, todes, botanicals and products produced by microorganisms fatty esters of polyols, and derivatives of the compounds including proteins or secondary metabolites, particularly containing Sulphates, Sulphonates and phosphates. The pres (C8.1) Halpin, whereas a composition means a composition ence of a surfactant is required if one of the active com of the combination together with the above mentioned pounds or one of the inert carriers is insoluble in water and agriculturally suitable auxiliaries, solvents, carriers, Surfac when the application takes place in water. The proportion of tants or extenders, in a form as Suitable for agrochemical surfactants is between 5 and 40% by weight of the compo application. sition according to the invention. 0379 According to the invention, carrier is to be under 0385. It is possible to use colorants such as inorganic stood as meaning a natural or synthetic, organic or inorganic pigments, for example iron oxide, titanium oxide, Prussian substance which is mixed or combined with the active blue, and organic dyes, such as alizarin dyes, azo dyes and compounds for better applicability, in particular for appli metal phthalocyanine dyes, and trace nutrients, such as salts cation to plants or plant parts or seeds. The carrier, which of iron, manganese, boron, copper, cobalt, molybdenum and may be solid or liquid, is generally inert and should be Z10. Suitable for use in agriculture. 0386 If appropriate, other additional components may 0380 Suitable solid or liquid carriers are: for example also be present, for example protective colloids, binders, ammonium salts and natural ground minerals. Such as adhesives, thickeners, thixotropic Substances, penetrants, kaolins, clays, talc, chalk, quartZ, attapulgite, montmorillo stabilizers, sequestering agents, complex formers. In gen nite or diatomaceous earth, and ground synthetic minerals, eral, the active compounds can be combined with any solid Such as finely divided silica, alumina and natural or synthetic or liquid additive customarily used for formulation pur silicates, resins, waxes, Solid fertilizers, water, alcohols, poses. especially butanol, organic solvents, mineral oils and Veg 0387. In general, the compositions according to the etable oils, and also derivatives thereof. It is also possible to invention comprise between 0.01 and 99% by weight, 0.05 use mixtures of such carriers. Solid carriers suitable for and 98% by weight, preferable between 0.1 and 95% by granules are: for example crushed and fractionated natural weight, particularly preferred between 0.5 and 90% by minerals, such as calcite, marble, pumice, Sepiolite, dolo weight of the active compound combination according to the mite, and also synthetic granules of inorganic and organic invention, very particularly preferable between 10 and 70% meals and also granules of organic material. Such as saw by weight. dust, coconut shells, maize cobs and tobacco stalks. 0388. The active compound combinations or composi 0381 Suitable liquefied gaseous extenders or carriers are tions according to the invention can be used as Such or, liquids which are gaseous at ambient temperature and under depending on their respective physical or chemical proper atmospheric pressure, for example aerosol propellants. Such ties, in the form of their formulations or the use forms as butane, propane, nitrogen and carbon dioxide. prepared therefrom, Such as aerosols, capsule Suspensions, 0382 Tackifiers, such as carboxymethylcellulose and cold-fogging concentrates, warm-fogging concentrates, natural and synthetic polymers in the form of powders, encapsulated granules, fine granules, flowable concentrates granules and latices, such as gum arabic, polyvinyl alcohol, for the treatment of seed, ready-to-use solutions, dustable polyvinyl acetate, or else natural phospholipids, such as powders, emulsifiable concentrates, oil-in-water emulsions, cephalins and lecithins and synthetic phospholipids can be water-in-oil emulsions, macrogranules, microgranules, oil used in the formulations. Other possible additives are min dispersible powders, oil-miscible flowable concentrates, oil eral and vegetable oils and waxes, optionally modified. miscible liquids, foams, pastes, pesticide-coated seed, Sus 0383. If the extender used is water, it is also possible for pension concentrates, Suspoemulsion concentrates, soluble example, to use organic solvents as auxiliary solvents. concentrates, Suspensions, wettable powders, soluble pow Suitable liquid solvents are essentially: aromatic com ders, dusts and granules, water-soluble granules or tablets, pounds, such as Xylene, toluene or alkylnaphthalenes, chlo water-soluble powders for the treatment of seed, wettable rinated aromatic compounds or chlorinated aliphatic hydro powders, natural products and synthetic Substances impreg carbons, such as chlorobenzenes, chloroethylenes or nated with active compound, and also microencapsulations methylene chloride, aliphatic hydrocarbons, such as cyclo in polymeric Substances and in coating materials for seed, hexane or paraffins, for example mineral oil fractions, min and also ULV cold-fogging and warm-fogging formulations. eral and vegetable oils, alcohols, such as butanol or glycol, 0389. The formulations mentioned can be prepared in a and also ethers and esters thereof, ketones, such as acetone, manner known per se, for example by mixing the active methyl ethyl ketone, methyl isobutyl ketone or cyclo compounds or the active compound combinations with at hexanone, strongly polar solvents, such as dimethylforma least one additive. Suitable additives are all customary mide and dimethyl Sulphoxide, and also water. formulation auxiliaries, such as, for example, organic Sol US 2016/0286803 A1 Oct. 6, 2016

vents, extenders, solvents or diluents, solid carriers and phytopathogens is triggered by an infection of the seed fillers, Surfactants (such as adjuvants, emulsifiers, disper during storage or after sowing as well as during and after sants, protective colloids, wetting agents and tackifiers), germination of the plant. This phase is particularly critical dispersants or binders or fixatives, preservatives, dyes and since the roots and shoots of the growing plant are particu pigments, defoamers, inorganic and organic thickeners, larly sensitive, and even Small damage may result in a weak water repellents, if appropriate siccatives and UV stabilizers, plant (unhealthy plant), reduced yield and even in the death gibberellins and also water and further processing auxilia of the plant. ries. Depending on the formulation type to be prepared in 0396 The control of insects, nematodes or phytopatho each case, further processing steps such as, for example, wet gens by treating the seed of plants has been known for a long grinding, dry grinding or granulation may be required. time and is the Subject of continuous improvements. How 0390 The compositions according to the invention do not ever, the treatment of seed entails a series of problems which only comprise ready-to-use compositions which can be cannot always be solved in a satisfactory manner Thus, it is applied with suitable apparatus to the plant or the seed, but desirable to develop methods for protecting the seed and the also commercial concentrates which have to be diluted with germinating plant which dispense with the additional appli water prior to use. cation of crop protection agents after sowing or after the 0391 The active compound combinations according to emergence of the plants or which at least considerably the invention can be present in (commercial) formulations reduce additional application. It is furthermore desirable to and in the use forms prepared from these formulations as a optimize the amount of agrochemicals employed in Such a mixture with other (known) active compounds, such as way as to provide maximum protection for the seed and the insecticides, attractants, sterilants, bactericides, acaricides, germinating plant from attack by agricultural pests, but nematicides, fungicides, growth regulators, herbicides, fer without damaging the plant itself by the active compound tilizers, Safeners and Semiochemicals. employed. In particular, methods for the treatment of seed 0392 The treatment according to the invention of the should also take into consideration the intrinsic insecticidal plants and plant parts with the active compounds or com or fungicidal or nematicidal properties of plants in order to positions is carried out directly or by action on their Sur achieve optimum protection of the seed and the germinating roundings, habitat or storage space using customary treat plant with a minimum of agrochemicals being employed. ment methods, for example by dipping, spraying, atomizing, 0397. The use or the method to use a compound (A) irrigating, evaporating, dusting, fogging, broadcasting, Fluopyram, (B) a spore-forming bacterium of the genera foaming, painting, spreading-on, Watering (drenching), drip Bacillus, selected from Bacillus firmus, Bacillus firmus irrigating and, in the case of propagation material, in par CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillus ticular in the case of seeds, furthermore as a powder for dry amyloliquefaciens, Bacillus subtilis strain GB03, Bacillus seed treatment, a solution for seed treatment, a water-soluble subtilis strain QST713, and (C) a biological control agent, in powder for slurry treatment, by incrusting, by coating with particular bacteria, fungi or yeasts, protozoa, viruses, ento one or more layers, etc. It is furthermore possible to apply mopathogenic nematodes, inoculants, botanicals and prod the active compound combination by the ultra-low volume ucts produced by microorganisms including proteins or method, or to inject the active compound combination or the secondary metabolites, particularly (C8.1) Harpin simulta active compound combination itself into the soil. neously or sequentially includes the following application 0393. Seed Treatment methods, namely both before mentioned components may 0394 Moreover the invention is directed to a method for be formulated into a single, stable composition with an protecting seeds comprising the step of simultaneously or agriculturally acceptable shelf life (so called “solo-formu sequentially applying a compound (A) Fluopyram, (B) a lation'), or being combined before or at the time of use (so spore-forming bacterium of the genera Bacillus, selected called “combined-formulations'), from Bacillus firmus, Bacillus firmus CNCMI-1582, Bacil 0398. The invention furthermore comprises a method for lus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, treating seed. The invention furthermore relates to seed Bacillus subtilis strain GB03, Bacillus subtilis strain treated according to one of the methods described in the QST713, and (C) a biological control agent, in particular preceding paragraphs. In the case of seed treatment, the bacteria, fungi or yeasts, protozoa, viruses, entomopatho treatment can be carried out by applying the compound (A) genic nematodes, inoculants, botanicals and products pro Fluopyram, (B) a spore-forming bacterium of the genera duced by microorganisms including proteins or secondary Bacillus, selected from Bacillus firmus, Bacillus firmus metabolites, particularly (C8.1) Harpin on a seed or a plant CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillus emerging from the seed. The method is further called “seed amyloliquefaciens, Bacillus subtilis strain GB03, Bacillus treatment. subtilis strain QST713, and (C) a biological control agent, in 0395. Using compound (A) Fluopyram, (B) a spore particular bacteria, fungi or yeasts, protozoa, viruses, ento forming bacterium of the genera Bacillus, selected from mopathogenic nematodes, inoculants, botanicals and prod Bacillus firmus, Bacillus firmus CNCM I-1582, Bacillus ucts produced by microorganisms including proteins or cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacil secondary metabolites, particularly (C8.1) Harpin as a solu lus subtilis strain GB03, Bacillus subtilis strain QST713, and tion, a powder (for dry seed treatment), a water-soluble (C) a biological control agent, in particular bacteria, fungi or powder (for slurry seed treatment), or by incrusting, by yeasts, protozoa, viruses, entomopathogenic nematodes, coating with one or more layers containing the compound inoculants, botanicals and products produced by microor (A) Fluopyram, (B) a spore-forming bacterium of the genera ganisms including proteins or secondary metabolites, par Bacillus, selected from Bacillus firmus, Bacillus firmus ticularly (C8.1) Harpin as a combination is particularly CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillus Suitable for treating seed. A large part of the damage to crop amyloliquefaciens, Bacillus subtilis strain GB03, Bacillus plants caused by harmful agricultural insects, nematodes or subtilis strain QST713, and (C) a biological control agent, in US 2016/0286803 A1 Oct. 6, 2016 32 particular bacteria, fungi or yeasts, protozoa, viruses, ento 04.04. It is also considered to be advantageous that the mopathogenic nematodes, inoculants, botanicals and prod active compound combinations or compositions according ucts produced by microorganisms including proteins or to the invention can be used in particular also for transgenic secondary metabolites, particularly (C8.1) Harpin. seed where the plant growing from this seed is capable of 0399. The active compound combinations or composi expressing a protein which acts against insects, nematodes tions according to the invention are especially suitable for or phytopathogens. By treating such seed with the active treating seed. A large part of the damage to crop plants compound combinations or compositions according to the caused by harmful organisms is triggered by an infection of invention, even by the expression of the, for example, the seed during storage or after sowing as well as during and insecticidal protein, certain insects, nematodes or phyto after germination of the plant. This phase is particularly pathogens may be controlled. Surprisingly, a further syner critical since the roots and shoots of the growing plant are gistic effect may be observed here, which additionally particularly sensitive, and even Small damage may result in increases the effectiveness of the protection against attack by the death of the plant. Accordingly, there is great interest in insects, nematodes or phytopathogens. protecting the seed and the germinating plant by using 04.05 The compositions according to the invention are appropriate compositions. Suitable for protecting seed of any plant variety employed in 0400. The control of phytopathogenic fungi by treating agriculture, in the greenhouse, in forests or in horticulture or the seed of plants has been known for a long time and is the viticulture. In particular, this takes the form of seed of Subject of continuous improvements. However, the treat cereals (such as wheat, barley, rye, triticale, millet, oats), ment of seed entails a series of problems which cannot maize (corn), cotton, Soya bean, rice, potatoes, Sunflowers, always be solved in a satisfactory manner. Thus, it is beans, coffee, beets (e.g. Sugar beets and fodder beets), desirable to develop methods for protecting the seed and the peanuts, oilseed rape, poppies, olives, coconuts, cacao, Sugar germinating plant which dispense with the additional appli cane, Sorghum, tobacco, vegetables (such as tomatoes, cation of crop protection agents after sowing or after the cucumbers, onions and lettuce), lawn and ornamental plants emergence of the plants or which at least considerably (also see below). reduce additional application. It is furthermore desirable to 0406. As also described further below, the treatment of optimize the amount of active compound combination transgenic seed with the active compound combinations or employed in Such a way as to provide maximum protection compositions according to the invention is of particular for the seed and the germinating plant from attack by insects, importance. This refers to the seed of plants containing at nematodes or phytopathogens, but without damaging the least one heterologous gene which allows the expression of plant itself by the active compound combination employed. a polypeptide or protein having insecticidal properties. The In particular, methods for the treatment of seed should also heterologous gene in transgenic seed can originate, for take into consideration the intrinsic fungicidal or insecticidal example, from microorganisms of the species Bacillus, or nematicidal properties of transgenic plants in order to Rhizobium, Pseudomonas, Serratia, Trichoderma, Clavi achieve optimum protection of the seed and the germinating bacter, Glomus or Gliocladium. Preferably, this heterolo plant with a minimum of crop protection agents being gous gene is from Bacillus sp., the gene product having employed. activity against the European corn borer or the Western corn rootworm. Particularly preferably, the heterologous gene 04.01. Accordingly, the present invention also relates in originates from Bacillus thuringiensis. particular to a method for protecting seed and germinating 0407. In the context of the present invention, the active plants against attack by insects, nematodes or phytopatho compound combinations or compositions according to the gens by treating the seed with a composition according to the invention are applied on their own or in a suitable formu invention. The invention also relates to the use of the lation to the seed. Preferably, the seed is treated in a state in compositions according to the invention for treating seed for which it is sufficiently stable so that the treatment does not protecting the seed and the germinating plant against insects, cause any damage. In general, treatment of the seed may nematodes or phytopathogens. Furthermore, the invention take place at any point in time between harvesting and relates to seed treated with a composition according to the Sowing. Usually, the seed used is separated from the plant invention for protection against insects, nematodes or phy and freed from cobs, shells, stalks, coats, hairs or the flesh topathogens. of the fruits. Thus, it is possible to use, for example, seed 0402. The control of insects, nematodes or phytopatho which has been harvested, cleaned and dried to a moisture gens which damage plants post-emergence is carried out content of less than 15% by weight. Alternatively, it is also primarily by treating the soil and the above-ground parts of possible to use seed which, after drying, has been treated, for plants with crop protection compositions. Owing to the example, with water and then dried again. concerns regarding a possible impact of the crop protection 0408. When treating the seed, care must generally be composition on the environment and the health of humans taken that the amount of the composition according to the and animals, there are efforts to reduce the amount of active invention applied to the seed or the amount of further compound combination applied. additives is chosen in Such a way that the germination of the 0403. One of the advantages of the present invention is seed is not adversely affected, or that the resulting plant is that, because of the particular systemic properties of the not damaged. This must be borne in mind in particular in the compositions according to the invention, treatment of the case of active compounds which may have phytotoxic seed with these compositions not only protects the seed effects at certain application rates. itself, but also the resulting plants after emergence, from 04.09. The compositions according to the invention can be insects, nematodes or phytopathogens. In this manner, the applied directly, that is to say without comprising further immediate treatment of the crop at the time of Sowing or components and without having been diluted. In general, it shortly thereafter can be dispensed with. is preferable to apply the compositions to the seed in the US 2016/0286803 A1 Oct. 6, 2016

form of a suitable formulation. Suitable formulations and purposes in agrochemical compositions. Preference is given methods for the treatment of seed are known to the person to cellulose derivatives, acrylic acid derivatives, polysac skilled in the art and are described, for example, in the charides, such as Xanthan gum or Veegum, modified clays, following documents: U.S. Pat. No. 4,272,417, U.S. Pat. No. phyllosilicates, such as attapulgite and bentonite, and also 4,245,432, U.S. Pat. No. 4,808,430, U.S. Pat. No. 5,876,739, finely divided silicic acids. US 2003/0176428 A1, WO 2002/080675, WO 2002/ 0418 Suitable adhesives that may be present in the seed O281.86. dressing formulations to be used according to the invention 0410 The active compound combinations which can be include all customary binders which can be used in seed used according to the invention can be converted into dressings. Polyvinylpyrrolidone, polyvinyl acetate, polyvi customary seed dressing formulations, such as Solutions, nyl alcohol and tylose may be mentioned as being preferred. emulsions, Suspensions, powders, foams, slurries or other 0419 Suitable gibberellins that may be present in the coating materials for seed, and also ULV formulations. seed dressing formulations to be used according to the 0411. These formulations are prepared in a known man invention are preferably the gibberellins A1, A3 (gibber ner by mixing the active compounds or active compound ellic acid), A4 and A7; particular preference is given to using combinations with customary additives, such as, for gibberellic acid. The gibberellins are known (cf. R. Wegler example, customary extenders and also solvents or diluents, “Chemie der Pflanzenschutz- and Schädlingsbe-kämp colorants, wetting agents, dispersants, emulsifiers, defoam fungsmittel Chemistry of Crop Protection Agents and ers, preservatives, secondary thickeners, adhesives, gibber Pesticides, Vol. 2, Springer Verlag, 1970, pp. 401-412). ellins and water as well. 0420. The seed dressing formulations which can be used 0412 Suitable colorants that may be present in the seed according to the invention may be used directly or after dressing formulations which can be used according to the dilution with water beforehand to treat seed of any of a very invention include all colorants customary for Such purposes. wide variety of types. The seed dressing formulations which Use may be made both of pigments, of sparing solubility in can be used according to the invention or their dilute water, and of dyes, which are soluble in water. Examples that preparations may also be used to dress seed of transgenic may be mentioned include the colorants known under the plants. In this context, synergistic effects may also arise in designations Rhodamine B. C. I. Pigment Red 112, and C. interaction with the Substances formed by expression. I. Solvent Red 1. 0421 Suitable mixing equipment for treating seed with 0413 Suitable wetting agents that may be present in the the seed dressing formulations which can be used according seed dressing formulations which can be used according to to the invention or the preparations prepared from them by the invention include all Substances which promote wetting adding water includes all mixing equipment which can and are customary in the formulation of active agrochemical commonly be used for dressing. The specific procedure substances. With preference it is possible to use alkylnaph adopted when dressing comprises introducing the seed into thalene-Sulphonates, such as diisopropyl- or diisobutylnaph a mixer, adding the particular desired amount of seed thalene-Sulphonates. dressing formulation, either as it is or following dilution 0414 Suitable dispersants or emulsifiers that may be with water beforehand, and carrying out mixing until the present in the seed dressing formulations which can be used formulation is uniformly distributed on the seed. Optionally, according to the invention include all nonionic, anionic, and a drying operation follows. cationic dispersants which are customary in the formulation 0422 The active compounds or compositions according of active agrochemical substances. With preference, it is to the invention have strong bactericidal or fungicidal or possible to use nonionic or anionic dispersants or mixtures insecticidal or nematicidal activity and can be used for of nonionic or anionic dispersants. Particularly Suitable controlling insects, nematodes or phytopathogens in crop nonionic dispersants are ethylene oxide-propylene oxide protection and material protection. block polymers, alkylphenol polyglycol ethers, and tristyryl 0423. In crop protection, fungicides can be used for phenol polyglycol ethers, and their phosphated or Sulphated controlling phytopathogens like Plasmodiophoromycetes, derivatives. Particularly suitable anionic dispersants are Oomycetes, Chytridiomycetes, Zygomycetes, Ascomycetes, lignoSulphonates, polyacrylic salts, and arylsulphonate Basidiomycetes and Deuteromycetes. formaldehyde condensates. 0424. In crop protection, bactericides can be used for 0415 Defoamers that may be present in the seed dressing controlling phytopathogens Pseudomonadaceae, Rhizobi formulations to be used according to the invention include aceae, Enterobacteriaceae, Corynebacteriaceae and Strepto all foam-inhibiting compounds which are customary in the mycetaceae. formulation of agrochemically active compounds. Prefer 0425 The fungicidal or insecticidal or nematicidal com ence is given to using silicone defoamers, magnesium Stear positions according to the invention can be used for the ate, silicone emulsions, long-chain alcohols, fatty acids and curative or protective control of insects, nematodes or phy their salts and also organofluorine compounds and mixtures topathogens. Accordingly, the invention also relates to cura thereof. tive and protective methods for controlling insects, nema 0416 Preservatives that may be present in the seed todes or phytopathogens using the active compound dressing formulations to be used according to the invention combinations or compositions according to the invention, include all compounds which can be used for Such purposes which are applied to the seed, the plant or plant parts, the in agrochemical compositions. By way of example, mention fruit or the soil in which the plants grow. Preference is given may be made of dichlorophen and benzyl alcohol hemifor to application onto the plant or the plant parts, the fruits or mal. the soil in which the plants grow. 0417 Secondary thickeners that may be present in the 0426. The compositions according to the invention for seed dressing formulations to be used according to the controlling insects, nematodes or phytopathogens in crop invention include all compounds which can be used for Such protection comprise an active, but non-phytotoxic amount of US 2016/0286803 A1 Oct. 6, 2016 34 the compounds according to the invention. “Active, but have been obtained by conventional breeding, by mutagen non-phytotoxic amount” shall mean an amount of the com esis or by recombinant DNA techniques. These can be position according to the invention which is sufficient to cultivars, bio- or genotypes. control or to completely kill the plant disease caused by 0431. The method of treatment according to the invention insects, nematodes or phytopathogens, which amount at the is used in the treatment of genetically modified organisms same time does not exhibit noteworthy symptoms of phy (GMO5), e.g. plants or seeds. Genetically modified plants (or totoxicity. These application rates generally may be varied in transgenic plants) are plants of which a heterologous gene a broader range, which rate depends on several factors, e.g. has been stably integrated into the genome. The expression the insects, nematodes or phytopathogens, the plant or crop, "heterologous gene' essentially means a gene which is the climatic conditions and the ingredients of the composi provided or assembled outside the plant and when intro tion according to the invention. duced in the nuclear, chloroplastic or mitochondrial genome 0427. The fact that the active compounds or active com gives the transformed plant new or improved agronomic or pound combinations, at the concentrations required for the other properties by expressing a protein or polypeptide of controlling of plant diseases, are well tolerated by plants interest or by down regulating or silencing other gene(s) permits the treatment of aerial plant parts, of vegetative which are present in the plant (using for example, antisense propagation material and seed, and of the soil. technology, co-suppression technology or RNA interference RNAi -technology). A heterologous gene that is located in 0428. According to the invention, it is possible to treat all the genome is also called a transgene. A transgene that is plants and parts of plants. Plants are to be understood here defined by its particular location in the plant genome is as meaning all plants and plant populations, such as wanted called a transformation or transgenic event. and unwanted wild plants or crop plants (including naturally 0432 Depending on the plant species or plant cultivars, occurring crop plants). Crop plants can be plants which can their location and growth conditions (soils, climate, vegeta be obtained by conventional breeding and optimization tion period, diet), the treatment according to the invention methods or by biotechnological and genetic engineering may also result in Super-additive (“synergistic) effects. methods or combinations of these methods, including the Thus, for example, reduced application rates or a widening transgenic plants and including plant cultivars which can or of the activity spectrum or an increase in the activity of the cannot be protected by plant variety protection rights. Parts active compound combinations and compositions which can of plants are to be understood as meaning all above-ground be used according to the invention, better plant growth, and below-ground parts and organs of the plants, such as increased tolerance to high or low temperatures, increased shoot, leaf flower and root, examples which may be men tolerance to drought or to water or soil salt content, tioned being leaves, needles, stems, trunks, flowers, fruit increased flowering performance, easier harvesting, accel bodies, fruits and seeds and also roots, tubers and rhizomes. erated maturation, higher harvest yields, bigger fruits, larger Plant parts also include harvested material and vegetative plant height, greener leaf color, earlier flowering, higher and generative propagation material, for example seedlings, quality or a higher nutritional value of the harvested prod tubers, rhizomes, bulbs, cuttings and seeds. Preference is ucts, higher Sugar concentration within the fruits, better given to the treatment of the plants and the above-ground storage stability or processability of the harvested products and below-ground parts and organs of the plants, such as are possible, which exceed the effects which were actually to shoot, leaf flower and root, examples which may be men be expected. tioned being leaves, needles, stems, trunks, flowers, and fruits. 0433. At certain application rates, the active compound combinations according to the invention may also have a 0429. The active compounds or active compound com strengthening effect in plants. Accordingly, they are also binations of the invention, in combination with good plant suitable for mobilizing the defense system of the plant tolerance and favourable toxicity to warm-blooded animals against attack by unwanted phytopathogenic fungi and/or and being tolerated well by the environment, are suitable for microorganisms or viruses. This may, if appropriate, be one protecting plants and plant organs, for increasing the harvest of the reasons of the enhanced activity of the combinations yields, for improving the quality of the harvested material. according to the invention, for example against fungi. Plant They may be preferably employed as crop protection agents. strengthening (resistance-inducing) Substances are to be They are active against normally sensitive and resistant understood as meaning, in the present context, those Sub species and against all or some stages of development. stances or combinations of Substances which are capable of 0430. As already mentioned above, it is possible to treat stimulating the defense system of plants in Such a way that, all plants and their parts according to the invention. In a when Subsequently inoculated with unwanted phytopatho preferred embodiment, wild plant species and plant culti genic fungi or microorganisms or viruses, the treated plants vars, or those obtained by conventional biological breeding display a substantial degree of resistance to these phyto methods, such as crossing or protoplast fusion, and parts pathogenic fungi or microorganisms or viruses, Thus, the thereof, are treated. In a further preferred embodiment, Substances according to the invention can be employed for transgenic plants and plant cultivars obtained by genetic protecting plants against attack by the abovementioned engineering methods, if appropriate in combination with phytopathogens within a certain period of time after the conventional methods (genetically modified organisms), and treatment. The period of time within which protection is parts thereof are treated. The terms “parts”, “parts of plants’ effected generally extends from 1 to 10 days, preferably 1 to and “plant parts” have been explained above. Particularly 7 days, after the treatment of the plants with the active preferably, plants of the plant cultivars which are in each compounds or active compound combinations. case commercially available or in use are treated according 0434 Plants and plant cultivars which are preferably to to the invention. Plant cultivars are to be understood as be treated according to the invention include all plants which meaning plants having novel properties (“traits') which have genetic material which impart particularly advanta US 2016/0286803 A1 Oct. 6, 2016

geous, useful traits to these plants (whether obtained by sterile plants is described in WO 89/10396 in which, for breeding or biotechnological means). example, a ribonuclease such as barnase is selectively 0435 Plants and plant cultivars which are also preferably expressed in the tapetum cells in the stamens. Fertility can to be treated according to the invention are resistant against then be restored by expression in the tapetum cells of a one or more biotic stresses, i.e. said plants show a better ribonuclease inhibitor such as barstar. defense against animal and microbial pests, such as against 0439 Plants or plant cultivars (obtained by plant biotech nematodes, insects, mites, phytopathogenic fungi, bacteria, nology methods such as genetic engineering) which may be viruses or viroids. treated according to the invention are herbicide-tolerant 0436 Plants and plant cultivars which may also be plants, i.e. plants made tolerant to one or more given treated according to the invention are those plants which are herbicides. Such plants can be obtained either by genetic resistant to one or more abiotic stresses. Abiotic stress transformation, or by selection of plants containing a muta conditions may include, for example, drought, cold tempera tion imparting Such herbicide tolerance. ture exposure, heat exposure, osmotic stress, flooding, 0440 Herbicide-tolerant plants are for example glypho increased soil salinity, increased mineral exposure, oZon sate-tolerant plants, i.e. plants made tolerant to the herbicide exposure, high light exposure, limited availability of nitro glyphosate or salts thereof. Plants can be made tolerant to gen nutrients, limited availability of phosphorus nutrients, glyphosate through different means. For example, glypho shade avoidance. sate-tolerant plants can be obtained by transforming the 0437. Plants and plant cultivars which may also be plant with a gene encoding the enzyme 5-enolpyruvylshi treated according to the invention, are those plants charac kimate-3-phosphate synthase (EPSPS). Examples of such terized by enhanced yield characteristics. Increased yield in EPSPS genes are the AroA gene (mutant CT7) of the said plants can be the result of for example, improved plant bacterium Salmonella typhimurium, the CP4 gene of the physiology, growth and development, such as water use bacterium Agrobacterium sp., the genes encoding a Petunia efficiency, water retention efficiency, improved nitrogen use, EPSPS, a Tomato EPSPS, or an Eleusine EPSPS. It can also enhanced carbon assimilation, improved photosynthesis, be a mutated EPSPS. increased germination efficiency and accelerated maturation. 0441 Glyphosate-tolerant plants can also be obtained by Yield can furthermore be affected by improved plant archi expressing a gene that encodes a glyphosate oxido-reductase tecture (under stress and non-stress conditions), including enzyme. Glyphosate-tolerant plants can also be obtained by but not limited to, early flowering, flowering control for expressing a gene that encodes a glyphosate acetyl trans hybrid seed production, seedling vigor, plant size, internode ferase enzyme. Glyphosate-tolerant plants can also be number and distance, root growth, seed size, fruit size, pod obtained by selecting plants containing naturally-occurring size, pod or ear number, seed number per pod or ear, seed mutations of the above-mentioned genes. mass, enhanced seed filling, reduced seed dispersal, reduced 0442. Other herbicide resistant plants are for example pod dehiscence and lodging resistance. Further yield traits plants that are made tolerant to herbicides inhibiting the include seed composition, such as carbohydrate content, enzyme glutamine synthase. Such as bialaphos, phosphino protein content, oil content and composition, nutritional thricin or glufosinate. Such plants can be obtained by value, reduction in anti-nutritional compounds, improved expressing an enzyme detoxifying the herbicide or a mutant processability and better storage stability. glutamine synthase enzyme that is resistant to inhibition. 0438 Plants that may be treated according to the inven One such efficient detoxifying enzyme is an enzyme encod tion are hybrid plants that already express the characteristic ing a phosphinothricin acetyltransferase (Such as the bar or of heterosis or hybrid vigor which results in generally higher pat protein from Streptomyces species). Plants expressing an yield, vigor, health and resistance towards biotic and abiotic exogenous phosphinothricin acetyltransferase are also stress factors. Such plants are typically made by crossing an described. inbred male-sterile parent line (the female parent) with 0443 Further herbicide-tolerant plants are also plants another inbred male-fertile parent line (the male parent). that are made tolerant to the herbicides inhibiting the Hybrid seed is typically harvested from the male sterile enzyme hydroxyphenylpyruvatedioxygenase (HPPD). plants and sold to growers. Male sterile plants can some Hydroxyphenylpyruvatedioxygenases are enzymes that times (e.g. in corn) be produced by detasseling, i.e. the catalyze the reaction in which para-hydroxyphenylpyruvate mechanical removal of the male reproductive organs (or (HPP) is transformed into homogentisate. Plants tolerant to males flowers) but, more typically, malesterility is the result HPPD-inhibitors can be transformed with a gene encoding a of genetic determinants in the plant genome. In that case, naturally-occurring resistant HPPD enzyme, or a gene and especially when seed is the desired product to be encoding a mutated HPPD enzyme. Tolerance to HPPD harvested from the hybrid plants it is typically useful to -inhibitors can also be obtained by transforming plants with ensure that male fertility in the hybrid plants is fully genes encoding certain enzymes enabling the formation of restored. This can be accomplished by ensuring that the male homogentisate despite the inhibition of the native HPPD parents have appropriate fertility restorer genes which are enzyme by the HPPD-inhibitor. Tolerance of plants to HPPD capable of restoring the male fertility in hybrid plants that inhibitors can also be improved by transforming plants with contain the genetic determinants responsible for male-ste a gene encoding an enzyme prephenate dehydrogenase in rility. Genetic determinants for male sterility may be located addition to a gene encoding an HPPD-tolerant enzyme. in the cytoplasm. Examples of cytoplasmic male sterility 0444 Still further herbicide resistant plants are plants that (CMS) were for instance described in Brassica species. are made tolerant to acetolactate synthase (ALS) inhibitors. However, genetic determinants for male sterility can also be Known ALS-inhibitors include, for example, sulfonylurea, located in the nuclear genome. Male sterile plants can also imidazolinone, triazolopyrimidines, pyrimidinyoxy (thio) be obtained by plant biotechnology methods such as genetic benzoates, or sulfonylaminocarbonyltriazolinone herbi engineering. A particularly useful means of obtaining male cides. Different mutations in the ALS enzyme (also known US 2016/0286803 A1 Oct. 6, 2016 36 as acetohydroxyacid synthase. AHAS) are known to confer 0456 8) protein of any one of 1) to 3) above wherein tolerance to different herbicides and groups of herbicides. Some, particularly 1 to 10, amino acids have been replaced The production of Sulfonylurea-tolerant plants and imida by another amino acid to obtain a higher insecticidal activity Zolinone-tolerant plants is described in WO 1996/033270. to a target insect species, or to expand the range of target Other imidazolinone-tolerant plants are also described. Fur insect species affected, or because of changes introduced ther Sulfonylurea- and imidazolinone-tolerant plants are also into the encoding DNA during cloning or transformation described in for example WO 2007/024782. (while still encoding an insecticidal protein), such as the 0445. Other plants tolerant to imidazolinone or sulfony VIP3Aa protein in cotton event COT102. lurea can be obtained by induced mutagenesis, selection in 0457. Of course, an insect-resistant transgenic plant, as cell cultures in the presence of the herbicide or mutation used herein, also includes any plant comprising a combina breeding as described for example for soybeans, for rice, for tion of genes encoding the proteins of any one of the above sugar beet, for lettuce, or for sunflower. classes 1 to 8. In one embodiment, an insect-resistant plant 0446. Plants or plant cultivars (obtained by plant biotech contains more than one transgene encoding a protein of any nology methods such as genetic engineering) which may one of the above classes 1 to 8, to expand the range of target also be treated according to the invention are insect-resistant insect species affected when using different proteins directed transgenic plants, i.e. plants made resistant to attack by at different target insect species, or to delay insect resistance certain target insects. Such plants can be obtained by genetic development to the plants by using different proteins insec transformation, or by selection of plants containing a muta ticidal to the same target insect species but having a different tion imparting Such insect resistance. mode of action, Such as binding to different receptor binding 0447. An “insect-resistant transgenic plant, as used sites in the insect. herein, includes any plant containing at least one transgene 0458 Plants or plant cultivars (obtained by plant biotech comprising a coding sequence encoding nology methods such as genetic engineering) which may 0448. 1) an insecticidal crystal protein from Bacillus also be treated according to the invention are tolerant to thuringiensis or an insecticidal portion thereof. Such as the abiotic stresses. Such plants can be obtained by genetic insecticidal crystal proteins listed online at: http://www. transformation, or by selection of plants containing a muta lifesci. Sussex.ac.uk/Home/Neil Crickmore/Bt/, or insecti tion imparting Such stress resistance. Particularly useful cidal portions thereof, e.g., proteins of the Cry protein stress tolerance plants include: classes Cry1Ab, Cry1Ac, Cry 1F, Cry2Ab, Cry3 Aa, or 0459 a. plants which contain a transgene capable of Cry3Bb or insecticidal portions thereof; or reducing the expression or the activity of poly(ADP-ri-bose) 0449 2) a crystal protein from Bacillus thuringiensis or polymerase (PARP) gene in the plant cells or plants a portion thereof which is insecticidal in the presence of a 0460 b. plants which contain a stress tolerance enhanc second other crystal protein from Bacillus thuringiensis or a ing transgene capable of reducing the expression or the portion thereof. Such as the binary toxin made up of the activity of the PARG encoding genes of the plants or plants Cry34 and Cry35 crystal proteins; or cells. 0461 c. plants which contain a stress tolerance enhancing 0450 3) a hybrid insecticidal protein comprising parts of transgene coding for a plant-functional enzyme of the nico different insecticidal crystal proteins from Bacillus thuringi tinamide adenine dinucleotide salvage synthesis pathway ensis, such as a hybrid of the proteins of 1) above or a hybrid including nicotinamidase, nicotinate phosphoribosyltrans of the proteins of 2) above, e.g., the Cry 1A.105 protein ferase, nicotinic acid mononucleotide adenyl transferase, produced by corn event MON98034 (WO 2007/027777); or nicotinamide adenine dinucleotide synthetase or nicotine 0451 4) a protein of any one of 1) to 3) above wherein amide phosphorybosyltransferase. Some, particularly 1 to 10, amino acids have been replaced 0462 Plants or plant cultivars (obtained by plant biotech by another amino acid to obtain a higher insecticidal activity nology methods such as genetic engineering) which may to a target insect species, or to expand the range of target also be treated according to the invention show altered insect species affected, or because of changes introduced quantity, quality or storage-stability of the harvested product into the encoding DNA during cloning or transformation, or altered properties of specific ingredients of the harvested such as the Cry3Bb1 protein in corn events MON863 or product Such as : MON88017, or the Cry3A protein in corn event MIR604; 0463. 1) transgenic plants which synthesize a modified 0452 5) an insecticidal secreted protein from Bacillus starch, which in its physical-chemical characteristics, in thuringiensis or Bacillus cereus, or an insecticidal portion particular the amylose content or the amylose?amylopectin thereof, such as the vegetative insecticidal (VIP) proteins ratio, the degree of branching, the average chain length, the listed at: side chain distribution, the viscosity behaviour, the gelling 0453 http://www.lifesci.sussex.ac.uk/home/Neil Crick strength, the starch grain size or the starch grain morphol more/Bt/vip.html, e.g. proteins from the VIP3Aa protein ogy, is changed in comparison with the synthesised starch in class; or wild type plant cells or plants, so that this is better suited for 0454 6) secreted protein from Bacillus thuringiensis or special applications. Bacillus cereus which is insecticidal in the presence of a 0464. 2) transgenic plants which synthesize non starch second secreted protein from Bacillus thuringiensis or B. carbohydrate polymers or which synthesize non starch car cereus, such as the binary toxin made up of the VIP 1A and bohydrate polymers with altered properties in comparison to VIP2A proteins; or wild type plants without genetic modification. Examples are 0455 7) hybrid insecticidal protein comprising parts plants producing polyfructose, especially of the inulin and from different secreted proteins from Bacillus thuringiensis levan-type, plants producing alpha 1.4 glucans, plants pro or Bacillus cereus, such as a hybrid of the proteins in 1) ducing alpha-1,6 branched alpha-1,4-glucans, plants pro above or a hybrid of the proteins in 2) above; or ducing alternan, US 2016/0286803 A1 Oct. 6, 2016 37

0465 3) transgenic plants which produce hyaluronan. WO2006/128569); Event 1143-51B (cotton, insect control, 0466 Plants or plant cultivars (that can be obtained by not deposited, described in WO2006/128570): Event 1445 plant biotechnology methods such as genetic engineering) (cotton, herbicide tolerance, not deposited, described in which may also be treated according to the invention are US2002120964 or WO2002/034946); Event 17053 (rice, plants, such as cotton plants, with altered fiber characteris herbicide tolerance, deposited as PTA-9843, described in tics. Such plants can be obtained by genetic transformation WO2010/117737); Event 17314 (rice, herbicide tolerance, or by selection of plants contain a mutation imparting Such deposited as PTA-9844, described in WO2010/117735); altered fiber characteristics and include: Event 281-24-236 (cotton, insect control herbicide toler 0467 a) Plants, such as cotton plants, containing an ance, deposited as PTA-6233, described in WO2005/103266 altered form of cellulose synthase genes, or US2005216969): Event 3006-210-23 (cotton, insect con 0468 b) Plants, such as cotton plants, containing an trol herbicide tolerance, deposited as PTA-6233, described altered form of rSW2 or rSW3 homologous nucleic acids, in US2007 143876 or WO2005/103266): Event 3272 (corn, 0469 c) Plants, such as cotton plants, with increased quality trait, deposited as PTA-9972, described in expression of Sucrose phosphate synthase, WO2006098952 or US2006230473); Event 40416 (corn, 0470 d) Plants, such as cotton plants, with increased insect control herbicide tolerance, deposited as ATCC expression of Sucrose synthase, PTA-11508, described in WO2011/075593); Event 43A47 0471 e) Plants, such as cotton plants, wherein the timing (corn, insect control—herbicide tolerance, deposited as of the plasmodesmatal gating at the basis of the fiber cell is ATCC PTA-11509, described in WO2011/075595): Event altered, e.g. through downregulation of fiberselective B 5307 (corn, insect control, deposited as ATCC PTA-9561, 1.3-glucanase, described in WO2010/077816); Event ASR-368 (bent grass, 0472 f) Plants, such as cotton plants, having fibers with herbicide tolerance, deposited as ATCC PTA-4816, altered reactivity, e.g. through the expression of N-acteylg described in US2006162007 or WO2004053062): Event lucosaminetransferase gene including nodC and chitinsyn B16 (corn, herbicide tolerance, not deposited, described in thase genes. US2003126634); Event BPS-CV127-9 (soybean, herbicide 0473 Plants or plant cultivars (that can be obtained by tolerance, deposited as NCIMB No. 41603, described in plant biotechnology methods such as genetic engineering) WO2010/080829): Event CE43-67B (cotton, insect control, which may also be treated according to the invention are deposited as DSM ACC2724, described in US20092.17423 plants, such as oilseed rape or related Brassica plants, with or WO2006/128573); Event CE44-69D (cotton, insect con altered oil profile characteristics. Such plants can be trol, not deposited, described in US20100024077); Event obtained by genetic transformation or by selection of plants CE44-69D (cotton, insect control, not deposited, described contain a mutation imparting Such altered oil characteristics in WO2006/128571): Event CE46-02A (cotton, insect con and include: trol, not deposited, described in WO2006/128572): Event 0474 a) Plants, such as oilseed rape plants, producing oil COT102 (cotton, insect control, not deposited, described in having a high oleic acid content, US2006130175 or WO2004039986); Event COT202 (cot 0475 b) Plants such as oilseed rape plants, producing oil ton, insect control, not deposited, described in having a low linolenic acid content, US2007067868 or WO2005054479): Event COT203 (cot 0476 c) Plant such as oilseed rape plants, producing oil ton, insect control, not deposited, described in WO2005/ having a low level of Saturated fatty acids. 054480); Event DAS40278 (corn, herbicide tolerance, 0477 Particularly useful transgenic plants which may be deposited as ATCC PTA-10244, described in WO2011/ treated according to the invention are plants which comprise 022469): Event DAS-59122-7 (corn, insect control herbi one or more genes which encode one or more toxins, such cide tolerance, deposited as ATCC PTA 11384, described in as the following which are sold under the trade names US2006070139): Event DAS-59132 (corn, insect control YIELD GARDR (for example maize, cotton, soya beans), herbicide tolerance, not deposited, described in WO2009/ KnockCutO (for example maize), BiteCard(R) (for example 100188); Event DAS68416 (soybean, herbicide tolerance, maize), Bt-Xtra.R. (for example maize), StarLink R. (for deposited as ATCC PTA-10442, described in WO2011/ example maize), Bollgard(R) (cotton), Nucotnir (cotton), 0.66384 or WO2011/066360): Event DP-098140-6 (corn, Nucotn 33B(R(cotton), NatureGard(R) (for example maize), herbicide tolerance, deposited as ATCC PTA-8296, ProtectaR) and New Leaf R (potato). Examples of herbicide described in US2009137395 or WO2008/112019); Event tolerant plants which may be mentioned are maize varieties, DP-305423-1 (soybean, quality trait, not deposited, cotton varieties and Soya bean varieties which are sold under described in US20083.12082 or WO2008/054747); Event the trade names Roundup Ready ED (tolerance to glypho DP-32138-1 (corn, hybridization system, deposited as sate, for example maize, cotton, Soya bean), Liberty Link R. ATCC PTA-9158, described in US20090210970 or (tolerance to phosphinotricin, for example oilseed rape), WO2009/103049): Event DP-356043-5 (soybean, herbicide IMF) (tolerance to imidazolinones) and STS ED (tolerance tolerance, deposited as ATCC PTA-8287, described in to Sulphonylureas, for example maize) Herbicide-resistant US20100184079 or WO2008/002872); Event EE-1 (brinjal, plants (plants bred in a conventional manner for herbicide insect control, not deposited, described in WO2007/ tolerance) which may be mentioned include the varieties 0.91277); Event FI117 (corn, herbicide tolerance, deposited sold under the name Clearfield(R) (for example maize) Par as ATCC 209031, described in US2006059581 or WO 1998/ ticularly useful transgenic plants which may be treated 044140); Event GA21 (corn, herbicide tolerance, deposited according to the invention are plants containing transforma as ATCC 209033, described in US2005086719 or WO 1998/ tion events, or a combination of transformation events, and 044140); Event GG25 (corn, herbicide tolerance, deposited that are listed for example in the databases for various as ATCC 209032, described in US2005188434 or WO 1998/ national or regional regulatory agencies including Event 044140); Event GHB 119 (cotton, insect control herbicide 1143-14A (cotton, insect control, not deposited, described in tolerance, deposited as ATCC PTA-8398, described in US 2016/0286803 A1 Oct. 6, 2016

WO2008/151780); Event GHB614 (cotton, herbicide toler trol herbicide tolerance, deposited as ATCC PTA-5582, ance, deposited as ATCC PTA-6878, described in described in US20080284.82 or WO2005/059103): Event US2010050282 or WO2007/017186); Event GJ11 (corn, MON88913 (cotton, herbicide tolerance, deposited as ATCC herbicide tolerance, deposited as ATCC 209030, described PTA-4854, described in WO2004/072235 O US2006059590); Event MON89034 (corn, insect control, in US2005188434 or WO 1998/044140); Event GM RZ13 deposited as ATCC PTA-7455, described in WO2007/ (sugar beet, virus resistance, deposited as NCIMB-41601, 140256 or US2008260932); Event MON89788 (soybean, described in WO2010/076212); Event H7-1 (sugar beet, herbicide tolerance, deposited as ATCC PTA-6708, herbicide tolerance, deposited as NCIMB 41158 or NCIMB described in US2006282915 or WO2006/130436): Event 41159, described in US2004172669 or WO2004/074492); MS11 (oilseed rape, pollination control herbicide toler Event JOPLIN1 (wheat, disease tolerance, not deposited, ance, deposited as ATCC PTA-850 or PTA-2485, described described in US2008064032): Event LL27 (soybean, herbi in WO2001/031042): Event MS8 (oilseed rape, pollination cide tolerance, deposited as NCIMB41658, described in control herbicide tolerance, deposited as ATCC PTA-730, WO2006/108674 or US2008320616); Event LL55 (soy described in WO2001/041558 or US2003188347); Event bean, herbicide tolerance, deposited as NCIMB 41660, NK603 (corn, herbicide tolerance, deposited as ATCC PTA described in W02006/108675 or US2008196127); Event 2478, described in US2007-292.854); Event PE-7 (rice, LLcotton25 (cotton, herbicide tolerance, deposited as ATCC insect control, not deposited, described in WO2008/ PTA-3343, described in WO2OO3O13224 O 114282); Event RF3 (oilseed rape, pollination control— US2003097.687); Event LLRICE06 (rice, herbicide toler herbicide tolerance, deposited as ATCC PTA-730, described ance, deposited as ATCC-23352, described in US6468747 or in WO2001/041558 or US2003 188347); Event RT73 (oil WO2000/026345); Event LLRICE601 (rice, herbicide tol seed rape, herbicide tolerance, not deposited, described in erance, deposited as ATCC PTA-2600, described in WO2002/036831 or US2008070260); Event T227-1 (sugar US20082289060 or WO2000/026356); Event LYO38 (corn, beet, herbicide tolerance, not deposited, described in quality trait, deposited as ATCC PTA-5623, described in WO2002/44407 or US2009265817); Event T25 (corn, her US2007028322 or WO2005061720): Event MIR162 (corn, bicide tolerance, not deposited, described in US2001029014 insect control, deposited as PTA-8166, described in or WO2001/051654); Event T304-40 (cotton, insect con US20093.00784 or WO2007/142840); Event MIR604 (corn, trol herbicide tolerance, deposited as ATCC PTA-8171, insect control, not deposited, described in US2008 167456 or described in US2010077501 or WO2008/122406); Event WO2005103301); Event MON15985 (cotton, insect control, T342-142 (cotton, insect control, not deposited, described in deposited as ATCC PTA-2516, described in US2004-250317 WO2006/128568); Event TC1507 (corn, insect control or WO2002/100163): Event MON810 (corn, insect control, herbicide tolerance, not deposited, described in not deposited, described in US2002102582): Event US2005039226 or WO2004/099447); Event VIP1034 (corn, MON863 (corn, insect control, deposited as ATCC PTA insect control herbicide tolerance, deposited as ATCC 2605, described in WO2004/011601 or US2006095986); PTA-3925., described in WO2003/052073), Event 32316 Event MON87427 (corn, pollination control, deposited as (corn.insect control herbicide tolerance.deposited as PTA ATCC PTA-7899, described in WO2011/062904); Event 11507, described in WO2011/084632), Event 4114 (corn, MON87460 (corn, stress tolerance, deposited as ATCC insect control herbicide tolerance, deposited as PTA PTA-8910, described in WO2009/111263 O 11506, described in WO2011/084621). US20110138504); Event MON87701 (soybean, insect con 0478 Particularly useful transgenic plants which may be trol, deposited as ATCC PTA-8194, described in treated according to the invention are plants containing US2009130071 or WO2009/064652); Event MON87705 transformation events, or combination of transformation (Soybean, quality trait-herbicide tolerance, deposited as events, that are listed for example in the databases from ATCC PTA-9241, described in US20100080887 or various national or regional regulatory agencies (see for WO2010/037016); Event MON87708 (soybean, herbicide example tolerance, deposited as ATCC PTA9670, described in 0479. http://gmoinfo.jrc.it/gmp browse.aspx and littp:// WO02011/034704); Event MON87754 (soybean, quality www.agbios.com.dbase.php). trait, deposited as ATCC PTA-9385, described in WO02010/ 0480 Particularly useful transgenic plants which may be 024976); Event MON87769 (soybean, quality trait, depos treated according to the invention are plants containing ited as ATCC PTA-8911, described in US20110067141 or transformation events, or combination of transformation WO2009/102873); Event MON88017 (corn, insect con events, are listed in table A

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0481. In material protection the active compounds or the Dermatophagoides pteronyssinus, Dermatophagoides fari active compound combinations of the invention may be used nae, Dermacentor spp., Eotetranychus spp., Epitrimerus for the protection of technical materials against infestation pyri, Eutetranychus spp., Eriophyes spp., Glycyphagus and destruction by insects, nematodes or phytopathogens. domesticus, Halotydeus destructor, Hemitarisonemus spp., 0482 Technical materials are understood to be in the Hyalomma spp., Ixodes spp., Latrodectus spp., Loxosceles present context non-living materials that have been prepared spp., Metatetranychus spp., Neutrombicula autumnalis, for use in engineering. For example, technical materials that Nuphersa spp., Oligonychus spp., Ornithodorus spp., Orni are to be protected against micro-biological change or thonyssus spp., Panonychus spp., Phylocoptruta oleivora, destruction by the active materials of the invention can be Polyphagotarisonemus latus, Psoroptes spp., Rhipicephalus adhesives, glues, paper and cardboard, textiles, carpets, spp., Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus, leather, wood, paint and plastic articles, cooling lubricants Steneotarisonemus spp., Steneotarisonemus spinki, Tarson and other materials that can be infested or destroyed by emus spp., Tetranychus spp., Trombicula alfreddugesi, Vae micro-organisms Within the context of materials to be jovis spp., Vasates lycopersici; protected are also parts of production plants and buildings, 0487 from the class Chilopoda, for example, Geophilus for example cooling circuits, cooling and heating systems, spp., Scutigera spp.; air conditioning and ventilation systems, which can be 0488 from the order or the class Collembola, for adversely affected by the propagation of fungi or microor example, Onychiurus armatus, ganisms Within the context of the present invention, pref 0489 from the class Diplopoda, for example, Blaniulus erably mentioned as technical materials are adhesives, glues, guttulatus, paper and cardboard, leather, wood, paints, cooling lubri 0490 from the class Insecta, e.g. from the order Blatto cants and heat exchanger liquids, particularly preferred is dea, for example, Blattella asahinai, Blattella germanica, wood. The combinations according to the invention can Blatta Orientalis, Leucophaea maderae, Panchlora spp., prevent disadvantageous effects like decaying, dis- and Parcoblatta spp., Periplaneta spp., Supella longipalpa, decoloring, or molding. The active compound combinations 0491 from the order Coleoptera, for example, Acalymma and compositions according to the invention can likewise be vittatum, Acanthoscelides Obtectus, Adoretus spp., Agellas employed for protecting against colonization of objects, in tica alni, Agriotes spp., Alphitobius diaperinus, Amphimal particular ship hulls, sieves, nets, buildings, quays and lon solstitialis, Anobium punctatum, Anoplophora spp., signalling installations, which are in contact with sea water Anthonomus spp., Anthrenus spp., Apion spp., Apogonia or brackish water. spp., Atomaria spp., Attagenus spp., Bruchidius Obtectus, 0483 The method of treatment according to the invention Bruchus spp., Cassida spp., Cerotoma trifurcata, Ceutor can also be used in the field of protecting storage goods rhynchus spp., Chaetocnema spp., Cleonus mendicus, against attack of insects, nematodes or phytopathogens. Conoderus spp., Cosmopolites spp., Costelytra zealandica, According to the present invention, the term "storage goods’ Ctenicera spp., Curculio spp., Cryptolestes ferrugineus, is understood to denote natural Substances of vegetable or Cryptorhynchus lapathi, Cylindrocopturus spp., Dermestes animal origin and their processed forms, which have been spp., Diabrotica spp., Dichocrocis spp., Dicladispa armig taken from the natural life cycle and for which long-term era, Diloboderus spp., Epilachna spp., Epitrix spp., Fausti protection is desired. Storage goods of vegetable origin, nus spp., Gibbium psylloides, Gnathocerus cornutus, Hel Such as plants or parts thereof, for example stalks, leafs, lula undalis, Heteronychus arator, Heteronyx spp., tubers, seeds, fruits or grains, can be protected in the freshly Hylamorpha elegans, Hylotrupes bajulus, Hypera postica, harvested State or in processed form, Such as pre-dried, Hypomeces squamosus, Hypothenemus spp., Lachnosterna moistened, comminuted, ground, pressed or roasted. Also consanguinea, Lasioderma serricorne, Latheticus Oryzae, falling under the defimition of storage goods is timber, Lathridius spp., Lema spp., Leptinotarsa decemlineata, Leu whether in the form of crude timber, such as construction coptera spp., Lissorhoptrus Oryzophilus, Lixus spp., Luper timber, electricity pylons and barriers, or in the form of Odes spp., Lyctus spp., Megascelis spp., Melanotus spp., fmished articles, such as furniture or objects made from Melligethes aeneus, Melolontha spp., Migdolus spp., Mono wood. Storage goods of animal origin are hides, leather, furs, chamus spp., Naupactus xanthographus, Necrobia spp., hairs and the like. The combinations according the present Niptus hololeucus, Oryctes rhinoceros, Oryzaephilus suri invention can prevent disadvantageous effects such as decay, namensis, Oryzaphagus Oryzae, Otiorrhynchus spp., Oxyc discoloration or mold. Preferably “storage goods” is under etonia jucunda, Phaedon cochleariae, Phyllophaga spp., stood to denote natural Substances of vegetable origin and Phyllophaga helleri, Phyllotreta spp., Popillia japonica, their processed forms, more preferably fruits and their Premnotrypes spp., ProStephanus truncatus, Psylliodes spp., processed forms, such as pomes, stone fruits, soft fruits and Ptinus spp., Rhizobius ventralis, Rhizopertha dominica, citrus fruits and their processed forms. Sitophilus spp., Sitophilus Oryzae, Sphenophorus spp., Ste 0484 Insects, nematodes or phytopathogens to be con gobium paniceum, Sternechus spp., Symphyletes spp., trolled when the compound (A), the spore-forming bacteria Tanymecus spp., Tenebrio molitor, Tenebrioides mauretani (B) and the biological control agents (C) are used or cus, Tribolium spp., Trogoderma spp., Tichius spp., Xylotre employed according to the invention are given hereafter: chus spp., Zabrus spp.; from the order Diptera, for example, 0485 Insects and Nematodes: Aedes spp., Agromyza spp., Anastrepha spp., Anopheles 0486 Insects are from the phylum Arthropoda, especially spp., Asphondylia spp., Bactrocera spp., Bibio hortulanus, from the class Arachnida, for example, Acarus spp., Aceria Caliphora erythrocephala, Caliphora vicina, Ceratitis Sheldoni, Aculops spp., Aculus spp., Amblyomma spp., capitata, Chironomus spp., Chrysomyia spp., Chrysops spp., Amphitetranychus viennensis, Argas spp., Boophilus spp., Chrysozona pluvialis, Cochliomyia spp., Contarinia spp., Brevipalpus spp., Bryobia graminum, Bryobia praetiosa, Cordylobia anthropophaga, Cricotopus Sylvestris, Culex Centruroides spp., Chorioptes spp., Dermanyssus gallinae, spp., Culicoides spp., Culiseta spp., Cuterebra spp., Dacus US 2016/0286803 A1 Oct. 6, 2016 58

Oleae, Dasy neura spp., Delia spp., Dermatobia hominis, spp., Sogatella fircifera, Sogatodes spp., Stictocephala fes Drosophila spp., Echinocnemus spp., Fannia spp., Gastero tina, Siphoninus philly reae, Tenalaphara malavensis, philus spp., Glossina spp., Haematopota spp., Hydrellia Tetragonocephela spp., Tinocallis caryaefoliae, Tomaspis spp., Hydrellia griseola, Hylelnya spp., Hippobosca spp., spp., Toxoptera spp., Trialeurodes vaporariorum, Trioza Hypoderma spp., Liriomyza spp., Lucilia spp., Lutzomyia spp., Tiphlocyba spp., Unaspis spp., Viteus vitifolii, Zygina spp., Mansonia spp., Musca spp., Oestrus spp., Oscinella frit, Spp., Paratanytarsus spp., Paralauterborniella subcincta, Pego 0493 from the order Hymenoptera, for example, Acro myia spp., Phlebotomus spp., Phorbia spp., Phormia spp., myrmex spp., Athalia spp., Atta spp., Diprion spp., Hoplo Piophila casei, Prodiplosis spp., Psila rosae, Rhagoletis campa spp., Lasius spp., Monomorium pharaonis, Sirex spp., Sarcophaga spp., Simulium spp., Stomoxy's spp., spp., Solenopsis invicta, Tapinoma spp., Urocerus spp., Tabanus spp., Tetanops spp., Tipula spp.; from the order Vespa spp., Xeris spp.; Heteroptera, for example, Anasa tristis, Antestiopsis spp., Boisea spp., Blissus spp., Calocoris spp., Campylomma 0494 from the order Isopoda, for example, Armadil livida, Cavelerius spp., Cimex spp., Collaria spp., Creon lidium vulgare, Oniscus asellus, Porcellio scaber, tiades dilutus, Dasynus piperis, Dichelops fircatus, Dicono 0495 from the order Isoptera, for example, Coptotermes coris hewetti, Dysdercus spp., Euschistus spp., Eurygaster spp., Cornitermes cumulans, Cryptotermes spp., Incisit spp., Heliopeltis spp., Horcias nobilellus, Leptocorisa spp., ermes spp., Microtermes Obesi, Odontotermes spp., Reticu Leptocorisa varicornis, Leptoglossus phyllopus, Lygus spp., litermes spp.; Macropes excavatus, Miridae, Monalonion atratum, Nezara 0496 from the order Lepidoptera, for example, Achroia spp., Oebalus spp., Pentomidae, Piesma quadrata, Piezodo grisella, Acronicta major; Adoxophyes spp., Aedia leu rus spp., Psallus spp., Pseudacy.sta persea, Rhodnius spp., comelas, Agrotis spp., Alabama spp., Amyelois transitella, Sahlbergella singularis, Scaptocoris Castanea, Scotino Anarsia spp., Anticarsia spp., Argyroploce spp., Barathra phora spp., Stephanitis nashi, Tibraca spp., Triatoma spp.; brassicae, Borbo cinnara, Bucculatrix thurberiella, Bupalus 0492 from the order Homoptera, for example, Acizzia piniarius, Busseola spp., Cacoecia spp., Caloptilia theivora, acaciaebaileyanae, Acizzia dodonaeae, AcizZia uncatoides, Capua reticulana, Carpocapsa pomonella, Carposina Acrida turrita, Acyrthosipon spp., Acrogonia spp., Aeneo niponensis, Cheinatobia brumata, Chilo spp., Choris lamia spp., Agonoscena spp., Aleyrodes proletella, Aleurolo toneura spp., Clysia ambiguella, Cnaphalocerus spp., bus barodensis, Aleurothrixus floccosus, Allocaridara Cnaphalocrocis medinalis, Cnephasia spp., Conopomorpha malavensis, Amrasca spp., Anuraphis cardui, Aonidiella spp., Conotrachelus spp., Copitarsia spp., Cydia spp., spp., Aphanostigma pini, Aphis spp., Arboridia apicalis, Dalaca noctuides, Diaphania spp., Diatraea saccharalis, Arytainilla spp., Aspidiella spp., Aspidiotus spp., Atanus Earias spp., Ecdytolopha aurantium, Elasmopalpus ligno spp., Aulacorthum Solani, Bemisia tabaci, Blastopsylla occi sellus, Eldana saccharina, Ephestia spp., Epinotia spp., dentalis, Boreioglycaspis melaleucae, Brachycaudus Epiphyas postvittana, Etiella spp., Eulia spp., Eupoecilia helichrysi, Brachycolus spp., Brevicoryne brassicae, Cacop ambiguella, Euproctis spp., Euxoa spp., Feltia spp., Galleria sylla spp., Calligypona marginata, Carneocephalafiulgida, mellonella, Gracillaria spp., Grapholitha spp., Hedylepta Ceratovacuna lanigera, Cercopidae, Ceroplastes spp., spp., Helicoverpa spp., Heliothis spp., Hofinannophila pseu Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita dospretella, Homoeosoma spp., Homona spp., Onuki, Chondracris rosea, Chromaphis juglandicola, Chry Hyponomeuta padella, Kakivoria flavofasciata, Laphygma somphalus ficus, Cicadulina mbila, Coccomytilus halli, Coc spp., Laspeyresia molesta, Leucinodes Orbonalis, Leucop cus spp., Cryptomyzus ribis, Cryptoneossa spp., Ctenar tera spp., Lithocolletis spp., Lithophane antennata, Lobesia vtaina spp., Dalbulus spp., Dialeurodes citri, Diaphorina spp., LOXagrotis albicosta, Lymantria spp., Lyonetia spp., citri, Diaspis spp., Drosicha spp., Dysaphis spp., Dysmic Malacosoma neustria, Maruca testulalis, Manstra brassi occus spp., Empoasca spp., Eriosoma spp., Erythroneura cae, Melanitis leda, Mocis spp., Monopis obviella, spp., Eucalyptolyma spp., Euphyllura spp., Euscelis biloba Mythinna separata, Nemapogon cloacellus, Nymphula spp., tus, Ferrisia spp., Geococcus coffeae, Glycaspis spp., Het Oiketicus spp., Oria spp., Orthaga spp., Ostrinia spp., eropsylla cubana, Heteropsylla spinulosa, Homalodisca Oulema Oryzae, Panolis flammea, Parnara spp., Pectino coagulata, Hyalopterus arundinis, Icerya spp., Idiocerus phora spp., Perileucoptera spp., Phthorimaea spp., Phyl spp., Idioscopus spp., Laodelphax striatellus, Lecanium locnistis citrella, Phyllonorycter spp., Pieris spp., Platynota spp., Lepidosaphes spp., Lipaphis erysimi, Macrosiphum Stultana, Plodia interpunctella, Plusia spp., Plutella xylos spp., Macrosteles facifions, Mahanarva spp., Melanaphis tella, Prays spp., Prodenia spp., Protoparce spp., Pseuda sacchari, Metcalfiella spp., Metopolophium dirhodium, letia spp., Pseudaletia unipuncta, Pseudoplusia includens, Monellia costalis, Monelliopsis pecanis, Myzus spp., Nason Pyrausta nubilalis, Rachiplusia nu, Schoenobius spp., Scir Ovia ribisnigri, Nephotettix spp., Nettigonicla spectra, pophaga spp., Scirpophaga innotata, Scotia Segetum, Sesa Nilaparvata lugens, Oncometopia spp., Orthezia praelonga, mia spp., Sesamia inferens, Sparganothis spp., Spodoptera Oxya chinensis, Pachypsylla spp., Parabemisia myricae, spp., Spodoptera praefica, Stathmopoda spp., Stomopteryx Paratrioza spp., Parlatoria spp., Pemphigus spp., Peregri subsecivella, Synanthedon spp., Tecia Solanivora, Therme nus maidis, Phenacoccus spp., Phloeomyzus passerinii, sia gemmatalis, Tinea cloacella, Tinea pellionella, Tineola Phorodon humuli, Phylloxera spp., Pinnaspis aspidistrae, bisselliella, Tortrix spp., Trichophaga tapetzella, Trichoplu Planococcus spp., Prosopidopsylla flava, Protopulvinaria sia spp., Tryporyza incertulas, Tuta absoluta, Virachola pyriformis, Pseudaulacaspis pentagona, Pseudococcus spp., Spp., Psyllopsis spp., Psylla spp., Pteromalus spp., Pyrilla spp., 0497 from the order Orthoptera or Saltatoria, for Quadraspidiotus spp., Quesada gigas, Rastrococcus spp., example, Acheta domesticus, Dichroplus spp., Gryllotalpa Rhopalosiphum spp., Saissetia spp., Scaphoideus titanus, spp., Hieroglyphus spp., Locusta spp., Melanoplus spp., Schizaphis graminum, Selenaspidus articulatus, Sogata Schistocerca gregaria, US 2016/0286803 A1 Oct. 6, 2016 59

0498 from the order Phthiraptera, for example, Dama combinations according to the invention is assessed by linia spp., Haematopinus spp., Linognathus spp., Pediculus comparing the mortality of nematodes, the development of spp., Ptirus pubis, Trichodectes spp.; galls, the formation of cysts, the concentration of nematodes 0499 from the order Psocoptera for example Lepinatus per Volume of soil, of cysts, the concentration of nematodes spp., LipOscelis spp.; per root, the number of nematode eggs per Volume of soil. 0500 from the order Siphonaptera, for example, Cerato the motility of the nematodes between a plant, a plant part phyllus spp., Ctenocephalides spp., Pulex irritans, Tunga or the Soil treated with a composition or combination penetrans, Xenopsylla cheopsis, according to the invention and the untreated plant, plant part 0501 from the order Thysanoptera, for example, Ana or soil (100%). Preferred is a reduction by 25-50% in phothrips obscurus, Baliothrips biformis, Drepanothrips comparison with the untreated plant, plant part or soil, very reuten, Enneothrips flavens, Frankliniella spp., Heliothrips preferred a reduction by 40-79%, and particularly preferred spp., Hercinothrips femoralis, Rhipiphorothrips Cmentatus, the complete killing and the complete prevention of the Scirtothrips spp., Taeniothrips cardamomi, Thrips spp.; development or growth by a reduction from 70% to 100% in 0502 from the order Zygentoma (=Thysanura), for comparison with the untreated plant, plant part or soil. example, Ctenolepisma spp., Lepisma saccharina, Lepis 0510) “Controlling nematodes' according to the inven modes inquilinus, Thermobia domestica, tion shall mean the control of the reproduction of the 0503 from the class Symphyla, for example, Scutigerella nematodes (e.g. development of cysts or eggs). The com Spp., positions according to the invention can used for keeping the 0504 pests from the phylum Mollusca, especially from plants healthy and can be used curatively, preventively or the class Bivalvia, for example, Dreissena spp., and from the systemically for controlling nematodes. class Gastropoda, for example, Anion spp., Biomphalaria 0511. The skilled person knows methods for determining spp., Bulinus spp., Deroceras spp., Galba spp., Lynnaea the mortality of nematodes, the development of galls, the spp., Oncomelania spp., Pomacea spp., Succinea spp.; formation of cysts, the concentration of nematodes per 0505 animal pests being nematodes from the phylums Volume of soil, of cysts, the concentration of nematodes per Plathelminthes and Nematoda, for example, Ancylostoma root, the number of nematode eggs per Volume of soil, the duodenale, Ancylostoma ceylanicum, Acylostoma brazilien motility of the nematodes between a plant, a plant part or the sis, Ancylostoma spp., Ascaris spp., Brugia malayi, Brugia soil. The treatment according to the invention reduces the timori, Bunostomum spp., Chabertia spp., Clonorchis spp., damages caused by nematodes to the plant and leads to an Cooperia spp., Dicrocoelium spp., Dictyocaulus filaria, increase in yield. Diphyllobothrium latum, Dracunculus medimensis, Echi 0512 “Nematodes' as used herein encompass all species nococcus granulosus, Echinococcus multilocularis, Entero of the order Nematoda and in particular species that are bius vermicularis, Faciola spp., Haemonchus spp., Hetera parasitic or cause health problems to plant or to fungi (for kis spp., Hymenolepis nana, Hvostrongulus spp., Loa Loa, example species of the orders Aphelenchida, Meloidogyne, Nematodirus spp., Oesophagostomum spp., Opisthorchis Tvlenchida and others) or to humans and animals (for spp., Onchocerca volvulus, Ostertagia spp., Paragonimus example species of the orders Trichinellida, Tilenchida, spp., Schistosomen spp., Strongyloides fielleboni, Strongy Rhabditina, and Spirurida) as well as other parasitic hel loides Stercoralis, Stromyloides spp., Taenia saginata, Taenia minths. solium, Trichinella spiralis, Trichinella nativa, Trichinella 0513 “Nematodes' as used herein, refer to plant nema britovi, Trichinella nelsoni, Trichinella pseudopsiralis, todes meaning plant parasitic nematodes that cause damage Tricho strongulus spp., Trichuris trichuria, Wuchereria ban to plants. Plant nematodes encompass plant parasitic nema crofti, todes and nematodes living in the soil. Plant parasitic 0506 phytoparasitic pests being nematodes from the nematodes include, but are not limited to, ectoparasites Such phylum Nematoda, for example, Aphelenchoides spp., Bur as Xiphinema spp., Longidorus spp., and Trichodorus spp.; Saphelenchus spp., Dity lenchus spp., Globodera spp., Het semiparasites such as Tvlenchulus spp., migratory endop erodera spp., Longidorus spp., Meloidogyne spp., Pratylen arasites Such as Pratylenchus spp., Radopholus spp., and chus spp., Radopholus spp., Trichodorus spp., Tilenchulus Scutellonerna spp.; sedentary parasites Such as Heterodera spp., Xiphinema spp., Helicotylenchus spp., Tvlenchorhyn spp., Globoderal spp., and Meloidogyne spp., and stem and chus spp., Scutellonema spp., Paratrichodorus spp., Melo leaf endoparasites such as Dity lenchus spp., Aphelenchoides inema spp., Paraphelenchus spp., Agilenchus spp., Belono spp., and Hirshmaniella spp. Especially harmful root para laimus spp., Nacobbus spp., Rotylenchulus spp., sitic soil nematodes are such as cyStforming nematodes of Rotylenchus spp., Neotylenchus spp., Paraphelenchus spp., the genera Heterodera or Globodera, and/or root knot nema Dolichodorus spp., Hoplolaimus spp., Punctodera spp., Cri todes of the genus Meloidogyne. Harmful species of these conemella spp., Ouinisulcius spp., Hemicycliophora spp., genera are for example Meloidogyne incognita, Heterodera Hirschmaniella spp., Anguina spp., Subanguina spp., Hemi glycines (soybean cyst nematode), Globodera pallida and criconenoides spp., Psilenchus spp., Pseudohalenchus spp., Globodera rostochiensis (potato cyst nematode), which spe Criconenoides spp., Cacopaurus spp. cies are effectively controlled with the compounds described 0507. The compositions according to the invention are herein. However, the use of the compounds described herein particularly useful in controlling nematodes. is in no way restricted to these genera or species, but also 05.08 Ein Nematizid im Pflanzenschutz, wie hier bes extends in the same manner to other nematodes. chrieben, bedeutet die Fähigkeit des Wirkstoffes, Nema 0514 Plant nematodes include but are not limited to e.g. toden Zu kontrollieren. Agilenchus agricola, Anguina tritici, Aphelenchoides 0509 “Controlling nematodes' according to the inven arachidis, Aphelenchoides fragaria and the stem and leaf tion shall mean to kill nematodes or to prevent their devel endoparasites Aphelenchoides spp. in general, Belonolaimus opment or growth. The efficacy of the compositions or gracilis, Belonolaimus longicaudatus, Belonolaimus nor US 2016/0286803 A1 Oct. 6, 2016 60 toni, Bursaphelenchus eremus, Bursaphelenchus xylophilus tus, Rotylenchus uniformis and Rotylenchus spp. in general, and Bursaphelenchus spp. in general, Cacopaurus pestis, Scutellonema brachyurum, Scutellonema brady's, Scutel Criconemella curvata, Criconemella Onoensis, Cricone lonema clathricaudatum and the migratory endoparasites mella ornata, Criconemella rusium, Criconemella xenoplax Scutellonema spp. in general, Subanguina radiciola, Tety Mesocriconema xenoplax) and Criconemella spp. in gen lenchus nicotianae, Trichodorus cylindricus, Trichodorus eral, Criconenoides ferniae, Criconenoides Onoense, Cri minor; Trichodorus primitivus, Trichodorus proximus, Trichodorus similis, Trichodorus sparsus and the ectopara conenoides ornatum and Criconenoides spp. in general, sites Trichodorus spp. in general, Tvlenchorhynchus agri, Dity lenchus destructor, Dity lenchus dipsaci, Dity lenchus Tvlenchorhynchus brassicae, Tilenchorhynchus clarus, myceliophagus and the stem and leaf endoparasites Dity len Tvlenchorhynchus claytoni, Tvlenchorhynchus digitatus, chus spp. in general, Dolichodorus heterocephalus, Glo Tvlenchorhynchus ebriensis, Tilenchorhynchus maximus, bodera pallida (-Heterodera pallida), Globodera Tvlenchorhynchus nudus, Tilenchorhynchus vulgaris and rostochiensis (potato cyst nematode), Globodera Solan Tvlenchorhynchus spp. in general, Tvlenchulus semipen acearum, Globodera tabacum, Globodera virginia and the etrans and the semiparasites Tilenchulus spp. in general, sedentary, cyst forming parasites Globodera spp. in general Xiphinema americanum, Xiphinema brevicolle, Xiphinema Helicotylenchus digonicus, Helicotylenchus dihystera, Heli dimorphicaudatum, Xiphinema index and the ectoparasites cotylenchus erythrine, Helicotylenchus multicinctus, Heli Xiphinema spp. in general. cotylenchus nannus, Helicotylenchus pseudorobustus and Helicotylenchus spp. in general, Hemicriconenoides, Hemi 0515. Examples of nematodes to which a nematicide of cycliophora arenaria, Hemicycliophora nudata, Hemicy the present invention is applicable include, but are not cliophora parvana, Heterodera avenae, Heterodera cruci limited to, nematodes of the genus Meloidogyne Such as the ferae, Heterodera glycines (soybean cyst nematode), Southern root-knot nematode (Meloidogyne incognita), Heterodera Oryzae, Heterodera Schachtii, Heterodera zeae Javanese root-knot nematode (Meloidogyne javanica), and the sedentary, cyst forming parasites Heterodera spp. in northern root-knot nematode (Meloidogyne hapla), and pea general, Hirschmaniella gracilis, Hirschmaniella Oryzae nut root-knot nematode (Meloidogyne arenaria); nematodes Hirschmaniella spinicaudata and the stem and leaf endop of the genus Dity lenchus such as the potato rot nematode arasites Hirschmaniella spp. in general, Hoplolaimus aegyp (Dity lenchus destructor) and bulb and stem nematode (Dity tii, Hoplolaimus Californicus, Hoplolaimus columbus, Hop lenchus dipsaci): nematodes of the genus Pratylenchus Such lolaimus galeatus, Hoplolaimus indicus, Hoplolaimus as the cob root-lesion nematode (Pratylenchus penetrans), magnistylus, Hoplolaimus pararobustus, Longidorus africa chrysanthemum root-lesion nematode (Pratylenchus fallax), nus, Longidorus breviannulatus, Longidorus elongatus, coffee root-lesion nematode (Pratylenchus coffeae), tea root Longidorus laevicapitatus, Longidorus vineacola and the lesion nematode (Pratylenchus loosi), and walnut root ectoparasites Longidorus spp. in general, Meloidogyne lesion nematode (Pratylenchus vulnus); nematodes of the acronea, Meloidogyne africana, Meloidogyne arenaria, genus Globodera Such as the golden nematode (Globodera Meloidogyne arenaria thanesi, Meloidogyne artiella, Melo rostochiensis) and potato cyst nematode (Globodera pal idogyne Chitwoodi, Meloidogyne coffeicola, Meloidogyne lida); nematodes of the genus Heterodera Such as the ethiopica, Meloidogyne exigua, Meloidogyne graminicola, Soybean cyst nematode (Heterodera glycines) and Sugar beet Meloidogyne graminis, Meloidogyne hapla, Meloidogyne cyst nematode (Heterodera Schachtii); nematodes of the incognita, Meloidogyne incognita acrita, Meloidogyne genus Aphelen.choides such as the rice white-tip nematode javanica, Meloidogyne kikuyensis, Meloidogyne naasi, (Aphelenchoides besseyi), chrysanthemum foliar nematode Meloidogyne paranaensis, Meloidogyne thanesi and the (Aphelenchoides ritzemabOsi), and strawberry nematode sedentary parasites Meloidogyne spp. in general, Meloinema (Aphelenchoides fragariae): nematodes of the genus Aph spp., Nacobbus aberrans, Neotylenchus vigilssi, Paraph elenchus such as the my cophagous nematode (Aphelenchus elenchus pseudoparietinus, Paratrichodorus allius, avenae); nematodes of the genus Radopholus such as the Paratrichodorus lobatus, Paratrichodorus minor, burrowing nematode (Radopholus similis); nematodes of the Paratrichodorus manus, Paratrichodorus porosus, genus Tilenchulus Such as the citrus nematode (Tvlenchulus Paratrichodorus teres and Paratrichodorus spp. in general, semipenetrans); nematodes of the genus Rotylenchulus Such Paratylenchus hamatus, Paratylenchus minutus, Paratylen as the reniform nematode (Rotylenchulus reniformis); nema chus projectus and Paratylenchus spp. in general, Pratylen todes that occur in trees, such as the pine wood nematode chus agilis, Pratylenchus alleni, Pratylenchus andinus, Pra (Bursaphelenchus xylophilus), and the like. tylenchus brachyurus, Pratylenchus cerealis, Pratylenchus 0516 Plants for which a nematicide of the present inven coffeae, Pratylenchus crenatus, Pratylenchus delaittrei, Pra tion can be used are not particularly limited; for example, tylenchus gibbicaudatus, Pratylenchus goodeyi, Pratylen plants such as cereals (for example, rice, barley, wheat, rye, chus hamatus, Pratylenchus hexincisus, Pratylenchus loosi, oat, corn, kaoliang 5 and the like), beans (soy-bean, azuki, Pratylenchus neglectus, Pratylenchus penetrans, Pratylen bean, broad bean, peas, peanuts and the like), fruit trees/ chus pratensis, Pratylenchus scribneri, Pratylenchus teres, fruits (apples, citruses, pears, grapes, peaches, Japanese Pratylenchus thornei, Pratylenchus vulnus, Pratylenchus apricots, cherries, walnuts, almonds, bananas, Strawberries zeae and the migratory endoparasites Pratylenchus spp. in and the like), vegetables (cabbage, tomato, spinach, broc general, Pseudohalenchus minutus, Psilenchus magnidens, coli, lettuce, onion, Welsh onion, pepper and the like), root Psilenchus tumidus, Punctodera chalcoensis, Ouinisulcius crops (carrot, potato, Sweet potato, radish, lotus root, turnip acutus, Radopholus citrophilus, Radopholus similis, the and the like), industrial crops (cotton, hemp, paper mulberry, migratory endoparasites Radopholus spp. in general, Roty mitsumata, rape, beet, hop, Sugarcane, Sugar beet, olive, lenchulus borealis, Rotylenchulus parvus, Rotylenchulus rubber, coffee, tobacco, tea and the like), pepos (pumpkin, reniformis and Rotylenchulus spp. in general, Rotylenchus cucumber, watermelon, melon and the like), pasture plants laurentinus, Rotylenchus macrodoratus, Rotylenchus robus (orchard grass, Sorghum, thimosy, clover, alfalfa and the US 2016/0286803 A1 Oct. 6, 2016 like), lawn grasses (mascarene grass, bent grass and the 0522 The compound(s) and compositions comprising the like), crops for flavorings etc. (lavender, rosemary, thyme, compound(s) of the present invention is/are particularly parsley, pepper, ginger and the like), and flower plants useful in controlling nematodes in corn belonging to at least (chrysanthemum, rose, orchids and the like) can be men one species selected from the group of the phytoparasitic tioned. nematodes, especially consisting of Belonolaimus longicau 0517. The compound(s) and compositions comprising the datus, Paratrichodorus minor and also consisting of Praty compound(s) of the present invention is/are particularly lenchus brachyurus, Pratylenchus delaittrei, Pratylenchus useful in controlling nematodes in coffee belonging to at hexincisus, Pratylenchus penetrans, Pratylenchus zeae, (Be least one species selected from the group of the phytopara lonolaimus gracilis), Belonolaimus nortoni, Longidorus sitic nematodes consisting of Pratylenchus brachyurus, Pra breviannulatus, Meloidogyne arenaria, Meloidogyne are tylenchus coffeae, Meloidogyne exigua, Meloidogyne incog naria thanesi, Meloidogyne graminis, Meloidogyne incog nita, Meloidogyne coffeicola, Helicotylenchus spp. and also nita, Meloidogyne incognita acrita, Meloidogyne javanica, consisting of Meloidogyne paranaensis, Rotylenchus spp., Meloidogyne naasi, Heterodera avenae, Heterodera Oryzae, Xiphinema spp., Tilenchorhynchus spp., Scutellonema spp. Heterodera zeae, Punctodera chalcoensis, Dity lenchus dipsaci, Hoplolaimus aegyptii, Hoplolaimus magnistylus, 0518 Compound(s) and compositions comprising com Hoplolaimus galeatus, Hoplolaimus indicus, Helicotylen pound(s) of the present invention is/are particularly useful in chus digonicus, Helicotylenchus dihystera, Helicotylenchus controlling nematodes in potato belonging to at least one pseudorobustus, Xiphinema americanum, Dolichodorus het species selected from the group of the phytoparasitic nema erocephalus, Criconemella ornata, Criconemella Onoensis, todes consisting of Pratylenchus brachyurus, Pratylenchus Radopholus similis, Rotylenchulus borealis, Rotylenchulus pratensis, Pratylenchus scribneri, Pratylenchus penetrans, parvus, Tilenchorhynchus agri, Tilenchorhynchus clarus, Pratylenchus coffeae, Dity lenchus dipsaci and also consist Tvlenchorhynchus claytoni, Tilenchorhynchus maximus, ing of Pratylenchus alleni, Pratylenchus andinus, Pratylen Tvlenchorhynchus nudus, Tilenchorhynchus vulgaris, Oui chus cerealis, Pratylenchus crenatus, Pratylenchus hexin cisus, Pratylenchus loosi, Pratylenchus neglectus, nisulcius acutus, Paratylenchus minutus, Hemicycliophora Pratylenchusteres, Pratylenchus thornei, Pratylenchus vul parvana, Agilenchus agricola, Anguina tritici, Aph nus, Belonolaimus longicaudatus, Trichodorus cylindricus, elen.choides arachidis, Scutellonema brachyurum, Sub Trichodorus primitivus, Trichodorus proximus, Trichodorus anguina radiciola. similis, Trichodorus sparsus, Paratrichodorus minor, 0523 The compound(s) and compositions comprising the Paratrichodorus allius, Paratrichodorus fanatiS, compound(s) of the present invention is/are particularly Paratrichodorus teres, Meloidogyne arenaria, Meloidogyne useful in controlling nematodes in Soybean belonging to at hapla, Meloidogyne thanesi, Meloidogyne incognita, Melo least one species selected from the group of the phytopara idogyne Chitwoodi, Meloidogyne javanica, Nacobbus aber sitic nematodes, especially consisting of Pratylenchus rans, Globodera rostochiensis, Globodera pallida, Dity len brachyurus, Pratylenchus pratensis, Pratylenchus pen chus destructor, Radopholus similis, Rotylenchulus etrans, Pratylenchus scribneri, Belonolaimus longicauda reniformis, Neotylenchus vigilssi, Paraphelenchus pseu tus, Heterodera glycines, Hoplolaimus columbus and also consisting of Pratylenchus coffeae, Pratylenchus hexincisus, doparietinus, Aphelenchoides fragariae, Meloinema spp. Pratylenchus neglectus, Pratylenchus crenatus, Pratylen 0519 Compound(s) and compositions comprising the chus alleni, Pratylenchus agilis, Pratylenchus zeae, Praty compound(s) of the present invention is/are particularly lenchus vulnus, (Belonolaimus gracilis), Meloidogyne are useful in controlling nematodes in tomato belonging to at naria, Meloidogyne incognita, Meloidogyne javanica, least one species selected from the group of the phytopara Meloidogyne hapla, Hoplolaimus columbus, Hoplolaimus sitic nematodes consisting of Meloidogyne arenaria, Melo galeatus, Rotylenchulus reniformis. idogyne hapla, Meloidogyne javanica, Meloidogyne incog 0524. The compound(s) and compositions comprising the nita, Pratylenchus penetrans and also consisting of compound(s) of the present invention is/are very particularly Pratylenchus brachyurus, Pratylenchus coffeae, Pratylen useful in controlling nematodes in Soybean belonging to at chus scribneri, Pratylenchus vulnus, Paratrichodorus least one species selected from the group of the phytopara minor, Meloidogyne exigua, Nacobbus aberrans, Globodera sitic nematodes, especially consisting of Pratylenchus Solanacearum, Dolichodorus heterocephalus, Rotylenchulus brachyurus, Pratylenchus pratensis, Pratylenchus pen reniformis. etrans, Pratylenchus scribneri, Belonolaimus longicauda 0520. The compound(s) and compositions comprising the tus, Hoplolaimus columbus and also consisting of Pratylen compound(s) of the present invention is/are particularly chus coffeae, Pratylenchus hexincisus, Pratylenchus useful in controlling nematodes in cucurbits belonging to at neglectus, Pratylenchus crenatus, Pratylenchus alleni, Pra least one species selected from the group of the phytopara tylenchus agilis, Pratylenchus zeae, Pratylenchus vulnus, sitic nematodes consisting of Meloidogyne arenaria, Melo (Belonolaimus gracilis), Meloidogyne arenaria, Meloid idogyne hapla, Meloidogyne javanica, Meloidogyne incog ogyne incognita, Meloidogyne javanica, Meloidogyne nita, Rotylenchulus reniformis and also consisting of hapla, Hoplolaimus columbus, Hoplolaimus galeatus, Roty Pratylenchus thornei. lenchulus reniformis. 0521. The compound(s) and compositions comprising the 0525. The compound(s) and compositions comprising the compound(s) of the present invention is/are particularly compound(s) of the present invention is/are particularly useful in controlling nematodes in cotton belonging to at useful in controlling nematodes in tobacco belonging to at least one species selected from the group of the phytopara least one species selected from the group of the phytopara sitic nematodes consisting of Belonolaimus longicaudatus, sitic nematodes, especially consisting of Meloidogyne Meloidogyne incognita, Hoplolaimus columbus, Hoplolai incognita, Meloidogyne javanica and also consisting of mus galeatus, Rotylenchulus reniformis. Pratylenchus brachyurus, Pratylenchus pratensis, Pratylen US 2016/0286803 A1 Oct. 6, 2016 62 chus hexincisus, Pratylenchus penetrans, Pratylenchus useful in controlling nematodes in tree crops pome fruits, neglectus, Pratylenchus crenatus, Pratylenchus thornei, belonging to at least one species selected from the group of Pratylenchus vulnus, Pratylenchus zeae, Longidorus elon the phytoparasitic nematodes, especially consisting of Pra gatu, Paratrichodorus lobatus, Trichodorus spp., Meloid tylenchus penetrans and also consisting of Pratylenchus ogyne arenaria, Meloidogyne hapla, Globodera tabacum, vulnus, Longidorus elongatus, Meloidogyne incognita, Globodera Solanacearum, Globodera virginiae, Dity lenchus Meloidogyne hapla. dipsaci, Rotylenchus spp., Helicotylenchus spp., Xiphinema 0531. The compound(s) and compositions comprising the americanum, Criconemella spp., Rotylenchulus reniformis, compound(s) of the present invention is/are particularly Tvlenchorhynchus claytoni, Paratylenchus spp., Tetvlenchus useful in controlling nematodes in tree crops stone fruits, nicotianae. belonging to at least one species selected from the group of 0526. The compound(s) and compositions comprising the the phytoparasitic nematodes, especially consisting of Pra compound(s) of the present invention is/are particularly tylenchus penetrans, Pratylenchus vulnus, Meloidogyne are useful in controlling nematodes in citrus belonging to at naria, Meloidogyne hapla, Meloidogyne javanica, Meloid least one species selected from the group of the phytopara ogyne incognita, Criconemella xenoplax and also consisting sitic nematodes, especially consisting of Pratylenchus cof of Pratylenchus brachyurus, Pratylenchus coffeae, Praty feae and also consisting of Pratylenchus brachyurus, Pra lenchus scribneri, Pratylenchus zeae, Belonolaimus longi tylenchus vulnus, Belonolaimus longicaudatus, caudatus, Helicotylenchus dihystera, Xiphinema america Paratrichodorus minor; Paratrichodorus porosus, Trichodo num, Criconemella curvata, Tvlenchorhynchus claytoni, rus, Meloidogyne incognita, Meloidogyne incognita acrita, Paratylenchus hamatus, Paratylenchus projectus, Scutel Meloidogyne javanica, Rotylenchus macrodoratus, Xiphi lonema brachyurum, Hoplolaimus galeatus. nema americanum, Xiphinema brevicolle, Xiphinema index, 0532. The compound(s) and compositions comprising the Criconemella spp., Hemicriconenoides, (Radopholus simi compound(s) of the present invention is/are particularly lis), Radopholus citrophilus, Hemicycliophora arenaria, useful in controlling nematodes in tree crops nuts, belonging Hemicycliophora nudata, Tvlenchulus semipenetrans. to at least one species selected from the group of the 0527 The compound(s) and compositions comprising the phytoparasitic nematodes, especially consisting of compound(s) of the present invention is/are particularly Trichodorus spp., Criconemella rusium and also consisting useful in controlling nematodes in banana belonging to at of Pratylenchus vulnus, Paratrichodorus spp., Meloidogyne least one species selected from the group of the phytopara incognita, Helicotylenchus spp., Tilenchorhynchus spp., sitic nematodes, especially consisting of Pratylenchus cof Cacopaurus pestis. feae, Radopholus similis and also consisting of Pratylenchus 0533. In a like manner, “nematodes' as used herein, refer gibbicaudatus, Pratylenchus loosi, Meloidogyne spp., Heli to nematodes which cause damage to humans or animals cotylenchus multicinctus, Helicotylenchus dihystera, Roty 0534 Specific nematode species harmful to humans or lenchulus spp. animals are: 0528. The compound(s) and compositions comprising the 0535 Trichinellida for example: Trichuris spp., Capil compound(s) of the present invention is/are particularly laria spp., Trichomosoides spp., Trichinella spp. useful in controlling nematodes in pine apple belonging to at 0536. From the order of the Tylenchida for example: least one species selected from the group of the phytopara Micronema spp., Strongyloides spp. sitic nematodes, especially consisting of Pratylenchus zeae, 0537. From the order of the Rhabditina for example: Pratylenchus pratensis, Pratylenchus brachyurus, Pratylen Strongylus spp., Triodontophorus spp., Oesophagodontus chus goodevi., Meloidogyne spp., Rotylenchulus reniformis spp., Trichonema spp., Gvalocephalus spp., Cylindrophar and also consisting of Longidorus elongatus, Longidorus lynx spp., Poteriostomum spp., Cyclococercus spp., Cyli laevicapitatus, Trichodorus primitivus, Trichodorus minor; costephanus spp., Oesophagostomum spp., Chabertia spp., Heterodera spp., Dity lenchus myceliophagus, Hoplolaimus Stephanurus spp., Ancylostoma spp., Uncinaria spp., Bunos Californicus, Hoplolaimus pararobustus, Hoplolaimus indi tomum spp., Globocephalus spp., Syngamus spp., Cya cus, Helicotylenchus dihystera, Helicotylenchus nannus, thostoma spp., Metastrongylus spp., Dictyocaulus spp., Helicotylenchus multicinctus, Helicotylenchus erythrine, Muellerius spp., Protostrongylus spp., Neostrongylus spp., Xiphinema dimorphicaudatum, Radopholus similis, Tvlen Cystocaulus spp., Pneumostrongylus spp., SpicoCaulus spp., chorhynchus digitatus, Tilenchorhynchus ebriensis, Paraty Elaphostrongylus spp. Parelaphostrongylus spp., Creno lenchus minutus, Scutellonema clathricaudatum, Scutel Soma spp., Paracrenosoma spp., Angiostrongylus spp., Ael lonema brady's, Psilenchus tumidus, Psilenchus magnidens, urostrongylus spp., Filaroides spp., Parafilaroides spp., Pseudohalenchus minutus, Criconenoides femiae, Cri Tricho strongylus spp., Haemonchus spp., Ostertagia spp., conenoides Onoense, Criconenoides ornatum. Marshallagia spp., Cooperia spp., Nematodirus spp., 0529. The compound(s) and compositions comprising the Hvostrongylus spp., Obeliscoides spp., Amidostomum spp., compound(s) of the present invention is/are particularly Ollulanus spp. useful in controlling nematodes in grapes belonging to at 0538 From the order of the Spirurida for example: least one species selected from the group of the phytopara Oxyuris spp., Enterobius spp., Passalurus spp., Syphacia sitic nematodes, especially consisting of Pratylenchus vul spp., Aspiculuris spp., Heterakis spp.; Ascaris spp., Toxas nus, Meloidogyne arenaria, Meloidogyne incognita, Melo caris spp., Toxocara spp., Baylisascaris spp., Parascaris idogyne javanica, Xiphinema americanum, Xiphinema index spp., Anisakis spp., Ascaridia spp., Gnathostoma spp., and also consisting of Pratylenchus pratensis, Pratylenchus Physaloptera spp., Thelazia spp., Gongylonema spp., scribneri, Pratylenchus neglectus, Pratylenchus brachyu Habronema spp., Parabronema spp., Draschia spp., Dra rus, Pratylenchus thornei, Tilenchulus semipenetrans. cunculus spp., Stephanofilaria spp., Parafilaria spp., Setaria 0530. The compound(s) and compositions comprising the spp., Loa spp., Dirofilaria spp., Litomosoides spp., Brugia compound(s) of the present invention is/are particularly spp., Wuchereria spp., Onchocerca spp. US 2016/0286803 A1 Oct. 6, 2016

0539 Many known nematicides are equally active Sphaerotheca diseases caused for example by Sphaerotheca against other parasitic helminths and are therefore used to fuliginea; Uncinula diseases caused for example by Unci control human and animal parasitic worms, which do not nula necator; necessarily belong to the group of nematoda. Therefore, it is 0550 Rust Diseases such as Gymnosporangium diseases envisaged by the present invention that the compounds caused for example by Gymnosporangium Sabinae, described herein may also be used as anthelmintic drugs in Hemileia diseases caused for example by Hemileia vasta a more general meaning. Pathogenic endoparasitic helmin trix, Phakopsora diseases caused for example by Phakop ths include platyhelmintha (eg monogenea, cestodes and Sora pachyrhizi and Phakopsora meibomiae, Puccinia dis trematodes), acanthocephala, and pentastoma. The follow eases caused for example by Puccinia recondita, Puccinia ing helminths may be mentioned by way of example and by graminis or Puccinia Striiformis, Uromyces diseases caused way of preference but without any limitation: for example by Uromyces appendiculatus, 0540 Monogenea: e.g.: Gyrodactylus spp., Dactylogyrus 0551 Oomycete Diseases such as Albugo diseases spp., Polystoma spp. caused for example by Albugo candida, Bremia diseases (0541 Cestodes: From the order of the Pseudophyllidea caused for example by Bremia lactucae, Peronospora dis for example: Diphyllobothrium spp., Spirometra spp., Schis eases caused for example by Peronospora pisi and Perono tocephalus spp., Ligula spp., Bothridium spp., Diplogonopo spora brassicae, Phytophthora diseases caused for example rus spp. by Phytophthora infestans, 0542. From the order of the Cyclophyllida for example: 0552. Plasmopara diseases caused for example by Plas Mesocestoides spp., Anoplocephala spp., Paranoplocephala mopara viticola, Pseudoperonospora diseases caused for spp., Moniezia spp., Thysanosoma spp., Thysaniezia spp., example by Pseudoperonospora humuli and PseudoperOno Avitellina spp., Stilesia spp., Cittotaenia spp., Andyra spp., spora cubensis, Pythium diseases caused for example by Bertiella spp., Taenia spp., Echinococcus spp., Hydatigera Pythium ultimum, spp., Davainea spp., Raillietina spp., Hymenolepis spp., 0553 Leaf spot, Leaf blotch and Leaf Blight Diseases Echinolepis spp., Echinocotyle spp., Diorchis spp., Dipy Such as Alternaria diseases caused for example by Alter lidium spp., Joyeuxiella spp., Diplopylidium spp. naria Solani; Cercospora diseases caused for example by 0543 Trematodes: From the class of the Digenea for Cercospora beticola, Cladiosporium diseases caused for example: Diplostomum spp., Posthodiplostomum spp., Schi example by Cladiosporium cucumerinum, Cochliobolus dis tosoma spp., Trichobilharzia spp., Ornithobilharzia spp., eases caused for example by Cochliobolus sativus (Conidi Austrobilharzia spp., Gigantobilharzia spp., Lencochlo aform. Drechslera, Syn. Helminthosporium) or Cochliobo ridium spp., Brachylaima spp., Echinostoma spp., Echin lus miyabeanus, Colletotrichum diseases caused for Opar phium spp., Echinochasmus spp., Hypoderaeum spp., example by Colletotrichum lindemuthianum, Cycloconium Fasciola spp., Fasciolides spp., Fasciolopsis spp., Cyclo diseases caused for example by Cycloconium Oleaginum, coelum spp., Tiphlocoelum spp., Paramphistomum spp., Diaporthe diseases caused for example by Diaporthe citri, Calicophoron spp., Cotylophoron spp., Gigantocotyle spp., Elsinoe diseases caused for example by Elsinoe fawcettii, Fischoederius spp., Gastrothylacus spp., Notocotylus spp., Gloeosporium diseases caused for example by Gloeospo Catatropis spp., Plagiorchis spp., Prosthogonimus spp., rium laeticolor, Glomerella diseases caused for example Dicrocoelium spp., Eurytrema spp., Troglotrema spp., Para by Glomerella Cingulata, Guignardia diseases caused for gonimus spp., Collyricium spp., Nanophyetus spp., Opist example by Guignardia bidwellii; Leptosphaeria diseases horchis spp., Clonorchis spp., Metorchis spp., Heterophyes caused for example by Leptosphaeria maculans and Lep spp., Metagoninus spp. tosphaeria nodorum, Magnaporthe diseases caused for 0544 Acantocephala: From the order of the Oligacan example by Magnaporthe grisea, Mycosphaerella diseases thorhynchida Z.B: Macracanthorhynchus spp., Prosthe caused for example by Mycosphaerella graminicola, norchis spp.; from the order of the Polymorphida for Mycosphaerella arachidicola and Mycosphaerella fijiensis, example: Filicollis spp.; from the order of the Monilifor Phaeosphaeria diseases caused for example by Phaeospha mida for example: Moniliformis spp., eria nodorum, Pyrenophora diseases caused for example by 0545 From the order of the Echinorhynchida for example Pyrenophora teres or Pyrenophora tritici repentis, Ramu Acanthocephalus spp., Echinorhynchus spp., Leptorhyn laria-diseases caused for example by Ranularia collo-Cygni choides spp. or Ranularia areola, Rhynchosporium diseases caused for 0546 Pentastoma: From the order of the Porocephalida example by Rhynchosporium secalis, Septoria diseases for example Linguatula spp. caused for example by Septoria apii and Septoria lycoper 0547. In the veterinary field and in animal keeping, the sici; Tiphula diseases caused for example by Thyphula administration of the active compounds according to the incarnata, Venturia diseases caused for example by Venturia invention is carried out in the known manner directly or inaequalis, enterally, parenterally, dermally or nasally in the form of 0554 Root-, Sheath and Stem Diseases such as Corti Suitable preparations. Administration can be carried out cium diseases caused for example by Corticium prophylactically or therapeutically. graminearum, Fusarium diseases caused for example by 0548. Some phytopathogens of fungal diseases which can Fusarium oxysporum, Gaeumannomyces diseases caused be treated by the combination according to the invention for example by Gaeumannomyces graminis, Rhizoctonia comprising compound (A), the spore-forming bacteria (B) diseases caused for example by Rhizoctonia Solani; Saro and the biological control agents (C) may be mentioned by cladium diseases caused for example by Sarocladium way of example, but not by way of limitation: Oryzae, Sclerotium diseases caused for example by Sclero (0549 Powdery Mildew Diseases such as Blumeria dis tium Oryzae, Tapesia diseases caused for example by Tape eases caused for example by Blumeria graminis; Podospha sia acuformis. Thielaviopsis diseases caused for example by era diseases caused for example by Podosphaera leucotricha; Thielaviopsis basicola, US 2016/0286803 A1 Oct. 6, 2016 64

0555 Ear and Panicle Diseases including Maize cob such dospora, Phaeoacremonium aleophilum and Fomitiporia as Alternaria diseases caused for example by Alternaria mediterranea, Ganoderma diseases caused for example by spp.; Aspergillus diseases caused for example by Aspergillus Ganoderma bominense, Rigidoporus diseases caused for flavus, Cladosporium diseases caused for example by Cla example by Rigidoporus lignosus diosporium cladosporioides, Claviceps diseases caused for 0561 Diseases of Flowers and Seeds such as Botrytis example by Claviceps purpurea, Fusarium diseases caused diseases caused for example by Botrytis cinerea, for example by Fusarium culmorum, Gibberella diseases 0562 Diseases of Tubers such asRhizoctonia diseases caused for example by Gibberella zeae, Monographella caused for example by Rhizoctonia Solani; Helminthospo diseases caused for example by Monographella nivalis, rium diseases caused for example by Helminthosporium Smut- and Bunt Diseases Such as Sphacelotheca diseases Solani; caused for example by Sphacelotheca reiliana, Tilletia dis 0563 Club root diseases such as Plasmodiophora dis eases caused for example by Tilletia caries, Urocystis dis eases, cause for example by Plamodiophora brassicae. eases caused for example by Urocystis occulta, Ustilago 0564 Diseases caused by Bacterial Organisms such as diseases caused for example by Ustilago nuda, Xanthomonas species for example Xanthomonas campestris 0556. Fruit Rot and Mould Diseases such as Aspergillus pV. Oryzae, Pseudomonas species for example Pseudomonas diseases caused for example by Aspergillus flavus, Botrytis syringae pv lachrymans, Erwinia species for example diseases caused for example by Botrytis cinerea, Penicil Erwinia amylovora. lium diseases caused for example by Penicillium expansium 0565 Preference is given to controlling the following and Penicillium purpurogenium, Rhizopus diseases caused diseases of Soya beans: by example by Rhizopus stolonifer Sclerotinia diseases 0566 Fungal diseases on leaves, stems, pods and seeds caused for example by Sclerotinia sclerotiorum, Verticillium caused, for example, by alternaria leaf spot (Alternaria spec. diseases caused for example by Verticillium alboatrum, atrans tenuissima), anthracnose (Colletotrichum gloeospor 0557. Seed- and Soilborne Decay, Mould, Wilt, Rot and Oides dematium var. truncatum), brown spot (Septoria gly Damping-off diseases caused for example by Alternaria cines), cercospora leaf spot and blight (Cercospora kikuchi diseases caused for example by Alternaria brassicicola, i).choanephora leaf blight (Choanephora infindibulifera Aphanomyces diseases caused for example by Aphanomyces trispora (Syn.)), dactuliophora leaf spot (Dactuliophora euteiches, Ascochyta diseases caused for example by Asco glycines), downy mildew (Peronospora manshurica), chyta lentis, Aspergillus diseases caused for example by drechslera blight (Drechslera glycini), frogeye leaf spot Aspergillus flavus, Cladosporium diseases caused for (Cercospora Sojina), leptosphaerulina leaf spot (Leptospha example by Cladosporium herbarum, Cochliobolus diseases erulina trifolii), phyllostica leaf spot (Phyllosticta caused for example by Cochliobolus sativus, (Conidiaform. sojaecola), pod and stem blight (Phomopsis sojae), powdery Drechslera, Bipolaris Syn: Helminthosporium); Colletotri mildew (Microsphaera diffusa), pyrenochaeta leaf spot chum diseases caused for example by Colletotrichum coc (Pyrenochaeta glycines), rhizoctonia aerial, foliage, and codes, Fusarium diseases caused for example by Fusarium web blight (Rhizoctonia Solani), rust (Phakopsora pachy culmorum, Gibberella diseases caused for example by Gib rhizi Phakopsora meibomiae), scab (Sphaceloma glycines), berella zeae, Macrophomina diseases caused for example by Stemphylium leaf blight (Stemphyllium botryosum), target Macrophomina phaseolina, Microdochium diseases caused spot (Corynespora cassicola). for example by Microdochium nivale, Monographella dis 0567 Fungal diseases on roots and the stem base caused, eases caused for example by Monographella nivalis, Peni for example, by black root rot (Calonectria crotalariae), cillium diseases caused for example by Penicillium expan charcoal rot (Macrophomina phaseolina), fitsarium blight or sum, Phoma diseases caused for example by Phoma lingam, wilt, root rot, and pod and collar rot (Fusarium oxysporum, Phomopsis diseases caused for example by Phomopsis Fusarium Orthoceras, Fusarium semitectum, Fusarium sojae, Phytophthora diseases caused for example by Phy equiseti), mycoleptodiscus root rot (Mycoleptodiscus ter tophthora cactorum, Pyrenophora diseases caused for restris), neocosmospora (Neocosmopspora vasinfecta), pod example by Pyrenophora graminea, Pyricularia diseases and stem blight (Diaporthe phaseolorum), stem canker caused for example by Pyricularia Oryzae, Pythium diseases (Diaporthe phaseolorum var. caulivora), phytophthora rot caused for example by Pythium ultimum, Rhizoctonia dis (Phytophthora megasperma), brown stem rot (Phialophora eases caused for example by Rhizoctonia Solani; Rhizopus gregata), pythium rot (Pythium aphanidermatum, Pythium diseases caused for example by Rhizopus Oryzae, Sclerotium irregulare, Pythium debaryanum, Pythium myriotylum, diseases caused for example by Sclerotium rolfsii; Septoria Pythium ultimum), rhizoctonia root rot, stem decay, and diseases caused for example by Septoria nodorum, Tiphula damping-off (Rhizoctonia Solani), Sclerotinia stem decay diseases caused for example by Tiphula incarnata, Verti (Sclerotinia sclerotiorum), sclerotinia Southern blight (Scle cillium diseases caused for example by Verticillium dahliae, rotinia rolfsii), thielaviopsis root rot (Thielaviopsis basi 0558 Canker, Broom and Dieback Diseases such as Cola). Nectria diseases caused for example by Nectria galligena, 0568. It is also possible to control resistant strains of the Blight Diseases such as Monilinia diseases caused for organisms mentioned above. example by Monilinia laxa, Leaf Blister or Leaf Curl 0569 Phytopathogens capable of degrading or changing Diseases including deformation of blooms and fruits such as the industrial materials which may be mentioned are, for Exobasidium diseases caused for example by Exobasidium example, bacteria, fungi, yeasts, algae and slime organisms. eXOS The active compound combinations and compositions 0559 Taphrina diseases caused for example by Taphrina according to the invention preferably act against phyto deformans, pathogens, in particular moulds, wood-discolouring and 0560 Decline Diseases of Wooden Plants such as Esca wood-destroying fungi (Basidiomycetes) and against Slime disease caused for example by Phaeomoniella clamy organisms and algae. Phytopathogens of the following gen US 2016/0286803 A1 Oct. 6, 2016

era may be mentioned as examples: Alternaria, such as 0577. The application of the active copmpound combi Alternaria tennis, Aspergillus, Such as Aspergillus niger; nation or compositions according to the invention on grow Chaetomium, Such as Chaetomium globosum, Coniophora, ing plants or plant parts can also be used to protect plants or Such as Coniophora puetana, Lentinus, such as Lentinus plant parts after harvesting. tigrinus, Penicillium, Such as Penicillium glaucum, Polypo 0578. According to the invention, post-harvest and stor rus, Such as Polyporus versicolor, Aureobasidium, Such as age diseases may be caused for example by the following Aureobasidium pullulans, Sclerophoma, Such as Sclero fungi: Colletotrichum spp., e.g. Colletotrichum musae, Col phoma pityophila, Trichoderma, such as Trichoderma letotrichum gloeosporioides, Colletotrichum coccodes, viride, Escherichia, Such as Escherichia coli, Pseudomonas, Fusarium spp., e.g. Fusarium semitectum, Fusarium monili Such as Pseudomonas aeruginosa, and Staphylococcus, Such forme, Fusarium Solani, Fusarium oxysporum, Verticillium as Staphylococcus aureus. spp., e.g. Verticillium theobromae, Nigrospora spp., Botrytis 0570. In addition, the combination comprising (A) Flu spp., e.g. Botrytis cinerea, Geotrichum spp., e.g. Geotri opyram, (B) a spore-forming bacterium of the genera Bacil chum candidum, Phomopsis spp., Phomopsis natalensis, lus, and (C) a biological control agent, in particular bacteria, Diplodia spp., e.g. Diplodia citri. Alternaria spp., e.g. fungi or yeasts, protozoa, viruses, entomopathogenic nema Alternaria citri, Alternaria alternata, Phytophthora spp., todes, inoculants, botanicals and products produced by e.g. Phytophthora citrophthora, Phytophthora fragariae, microorganisms including proteins or secondary metabo Phytophthora cactorum, Phytophthora parasitica, Septoria lites, particularly (C8.1) Harpin according to the invention spp., e.g. Septoria depressa, Mucor spp., e.g. Mucor piri also have very good antimycotic activity. They have a very formis, Monilinia spp., e.g. Monilinia fructigena, Monilinia broad antimycotic activity spectrum in particular against laxa, Venturia spp., e.g. Venturia inaequalis, Venturia dermatophytes and yeasts, moulds and diphasic fungi (for pyrina, Rhizopus spp., e.g. Rhizopus stolonifer; Rhizopus example against Candida species such as Candida albicans, Oryzae, Glomerella spp., e.g. Glomerella cingulata, Sclero Candida glabrata) and Epidermophyton floccosum, Asper tinia spp., e.g. Sclerotinia fruiticola, Ceratocystis spp., e.g. gillus species such as Aspergillus niger and Aspergillus Ceratocystis paradoxa, Penicillium spp., e.g. Penicillium filmigatus, Trichophyton species such as Trichophyton men finiculosum, Penicillium expansium, Penicillium digitatum, tagrophytes, Microsporon species Such as Microsporon Penicillium italicum, Gloeosporium spp., e.g. Gloeosporium canis and audouinii The list of these fungi by no means album, Gloeosporium perennans, Gloeosporium fructige limits the mycotic spectrum which can be covered, but is num, Gloeosporium singulata, Phlyctaena spp., e.g. Phlyc only for illustration. taena vagabunda, Cylindrocarpon spp., e.g. Cylindrocar pon malii Stemphyllium spp., e.g. Stemphyllium vesicarium, 0571 When applying the compounds or the active com Phacydiopycnis spp., e.g. Phacydiopycnis malirum, pound combination according to the invention the applica Thielaviopsis spp., e.g. Thielaviopsis paradoxy, Aspergillus tion rates can be varied within a broad range. The dose of spp., e.g. Aspergillus niger, Aspergillus carbonarius, Nec active compound combination/application rate usually tria spp., e.g. Nectria galligena, Pezicula spp. applied in the method of treatment according to the inven tion is generally and advantageously 0579. According to the invention, post-harvest storage disorders are for example scald, scorch, Softening, senescent 0572 for treatment of part of plants, e.g. leaves (foliar breakdown, lenticel spots, bitter pit, browning, water core, treatment): from 0.01 to 10,000 g/ha, preferably from 50 to vascular breakdown, CO injury, CO deficiency and O. 1,000 g/ha, more preferably from 100 to 750 g/ha; in case of deficiency. drench or drip application, the dose can even be reduced, especially while using inert Substrates like rockwool or 0580 Furthermore combinations and compositions perlite: according to the invention may also be used to reduce the contents of mycotoxins in plants and the harvested plant 0573 for seed treatment: from 2 to 250 g per 100 kg of material and therefore in foods and animal feed stuff made seed, preferably from 3 to 200 g per 100 kg of seed, more therefrom. Especially but not exclusively the following preferably from 2.5 to 50 g per 100 kg of seed, even more mycotoxins can be specified: Deoxynivalenole (DON). preferably from 2.5 to 25 g per 100 kg of seed; Nivalenole, 15-Ac-DON, 3-Ac-DON, T2-und HT2-Toxins, Fumonisines, Zearallenone Moniliformine, Fusarine, Dia 0574 for soil treatment: from 0.01 to 10,000 g/ha, pref ceotoxyscirpenole (DAS), Beauvericine, Enniatine, Fusaro erably from 1 to 5,000 g/ha. proliferine, Fusarenole, Ochratoxines, Patuline, Ergotalka 0575. The doses herein indicated are given as illustrative loides und Aflatoxins, which are caused for example by the examples of the method according to the invention. A person following fungal diseases: Fusarium spec., like Fusarium skilled in the art will know how to adapt the application acuminatum, F, avenaceum, E Crookwellense, F. culmorum, doses, notably according to the nature of the plant or crop to F. graminearum (Gibberella zeae), F equiseti, Ffitjikoroi, F. be treated. musarum, F. Oxysporum, F. proliferatum, F. poae, F. pseudo 0576. The active compound combination or composition graminearum, F. Sambucinum, F. Scirpi, F. Semitectum, F. according to the invention can be used in order to protect Solani, F. Sporotrichoides, F. langsethiae, F subglutinans, F. plants within a certain time range after the treatment against tricinctum, F. verticillioides and others but also by Asper pests or phytopathogenic fungi or microorganisms. The time gillus spec., Penicillium spec., Claviceps purpurea, Stachy range, in which protection is effected, spans in general 1 to botry's spec. and others. 28 days, preferably 1 to 14 days, more preferably 1 to 10 0581. The good fungicidal or insecticidal or nematicidal days, even more preferably 1 to 7 days after the treatment of activity of the active compound combinations according to the plants with the combinations or up to 200 days after the the invention is evident from the example below. While the treatment of plant propagation material. individual active compounds exhibit weaknesses with US 2016/0286803 A1 Oct. 6, 2016 66 regard to the fungicidal or insecticidal or nematicidal activ biological Suspension the cells or spores are diluted with ity, the combinations have an activity which exceeds a emulsifier-containing water to the desired concentration. simple addition of activities. 0597 Vessels are filled with sand, a solution of the active 0582. A synergistic effect of the combinations according ingredient, a suspension containing eggs and larvae of to the invention is always present when the fungicidal or Meloidogyne incognita and salad seeds. The salad seeds nematicidal or nematicidal activity of the active compound germinate and the seedlings grow. Galls develop in the roots. combinations exceeds the total of the activities of the active 0598. After the specified period of time the nematicidal compounds when applied individually. activity is determined on the basis of the percentage of gall 0583. The expected activity for a given combination of formation. When Meloidogyne incognita attacks roots of two active compounds can be calculated as follows (cf. plants, it deforms the normal root cells and establishes giant Colby, S. R. "Calculating Synergistic and Antagonistic cells and consequently the attacked roots form galls. 100% Responses of Herbicide Combinations”, Weeds 1967, 15, means that no galls were found: 0% means that the number 20-22): of galls found on the roots of the treated plants was equal to 0584) If that in untreated control plants. 0585 X is the efficacy when active compound A is 0599. The following combinations of Bacillus firmus applied at an application rate of m ppm (org/ha), CNCM I-1582, Fluopyram and an additional compound 0586 Y is the efficacy when active compound B is showed a synergistic effect according to the invention: applied at an application rate of n ppm (or g/ha), 0587 Z is the efficacy when employing active compound C at an application rate of r ppm (or g/ha), Concentration Mortality in 0588 E is the efficacy when the active compounds A and Active ingredient ppm % after 21 Bacilius firmus CNCM I-1582 1OO O B (or A and C, or B and C) are applied at application rates Fluopyram O.OOOS O of m and n (or m and r, or n and r) ppm (or g/ha), Bacilius thiringiensis Subsp. 10 O respectively, and tenebrionis 0589 E2 is the efficacy when employing active com Bacilius firmus CNCM I-1582 + obs. * ca.** pounds A and B and C at application rates of m and n and Fluopyram + B. thuringiensis 1OO + O.OOOS - 1 O 90 O r ppm (org/ha), tenebrionis 0590 then Metarhizium anisopliae strain F52 5 O Bacilius firmus CNCM I-1582 + Obs.* ca.* Fluopyram + M. anisopiae 100 + O.OOOS - 5 70 O X. Y strain F52 E = X -- Y - - 100 - *obs. = observed insecticidal efficacy, **cal. = efficacy calculated with Colby-formula 0591 and for a combination of 3 active compounds: 1. Active compound combination comprising: (A) Fluopyram, X. Y -- X. Z-- Y. Z, X . Y. Z (B) a spore-forming bacterium of the genera Bacillus, E = X +Y + Z-( ' ' 100 ' ()+ 1OOOO Selected from the group consistsing of Bacillus firmus, Bacillus firmus strain CNCM I-1582, Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillus 0592. The degree of efficacy, expressed in % is denoted. subtilis strain GB03, Bacillus subtilis strain QST713, 0% means an efficacy which corresponds to that of the and control while an efficacy of 100% means that no disease is (C) at least one biological control agent selected from the observed. group consisting of 0593. If the actual fungicidal or nematicidal activity (C1) bacteria, exceeds the calculated value, then the activity of the com (C2) fungi or yeasts, bination is Superadditive, i.e. a synergistic effect exists. In (C3) protozoas, this case, the efficacy which was actually observed must be (C4) viruses, greater than the value for the expected efficacy (E) calcu (C5) entomopathogenic nematodes, lated from the abovementioned formula. A further way of (C6) inoculants, demonstrating a synergistic effect is the method of Tammes (C7) botanicals, and (cf. 'Isoboles, a graphic representation of synergism in (C8.1) Harpin (produced by Erwinia amylovora); pesticides” in Neth, Plant Path., 1964, 70, 73-80). with the proviso that the spore-forming bacterium (B) of EXAMPLE 1. the genera Bacillus and the biological control agent (C) are not identical. 0594 Meloidogyne incognita-test (MELGIN) 2. Active compound combination according to claim 1, 0595 Solvent: 125.0 parts by weight of acetone wherein the combination has fungicidal and nematicidal and 0596 To produce a suitable preparation of active com optionally insecticidal activity. pound, 1 part by weight of active compound is mixed with 3. Active compound combination according to claim 1, the stated amount of solvent, and the concentrate is diluted wherein the spore-forming bacterium (B) of the genera with water to the desired concentration. The preparation of Bacillus is selected from the group consisting of the bacteria, fungi or yeast products contains 10-10' (B1) Bacillus firmus strain CNCM I-1582, spores/g or cells/g. To produce a suitable preparation of a (B2) Bacillus cereus strain CNCM I-1562, US 2016/0286803 A1 Oct. 6, 2016 67

(B3) Bacillus amyloliquefaciens strain IN937a, lautus, (C1.37) Bacillus atrophaeus, (C1.39) Bacillus (B4) Bacillus amyloliquefaciens strain FZB42, mycoides, optionally isolate J or strain 683 or strain (B5) Bacillus subtilis strain GB03, AQ726 (Accession No. NRRL B21664), (C1.40) Bacil (B6) Bacillus subtilis strain QST713, lus acidoterrestris, (C1.41) Bacillus fastidiosus, (C1. (B7) Bacillus pumilus strain GB34, 42) Bacillus megaterium, or strain YFM3.25. (C1.43) (B8) Bacillus pumilus strain QST2808. Bacillus psychrosaccharolyticus, (C1.44) Bacillus 4. Active compound combination according to claim 1, maroccanus, (C1.45) Bacillus megaterium C. (C1.46) wherein (C) is selected from the group consisting of Bacillus pantothenticus (also known as Virgibacillus (C1) bacteria including spore-forming, root-colonizing pantothenticus), in particular strain ATCC 14576/DSM bacteria, or bacteria useful as biofungicide, bioinsecti 491, (C1.47) Bacillus lentus, (C1.48) Bacillus badius, cide or nematicide selected from the group consisting (C1.49) Bacillus Smithi, (C1.50) Acinetobacter spec, of (C1.1) Bacillus agri, (C1.2) Bacillus aizawaii, (C1.3) (C1.51) Acinetobacter lwoffii, (C1.52) Bacillus lucifer Bacillus albolactis, (C1.6) Bacillus coagulans, (C1.7) ensis, (C1.53) Chronobacterium subtsugae, optionally Bacillus endoparasiticus, (C1.8) Bacillus endorhyth strain PRA A4-1T (C1.54) Pasteuria usgae, (C1.55) mos, (C1.9) Bacillus azotoformans, (C1.10) Bacillus Paenibacillus polymyxa, optionally strain AC-1, (C1. Kurstaki, (C1.11) Bacillus lacticola, (C1.12) Bacillus 57) Serratia entomophila, (C1.58) Bacillus chitinospo lactimorbus, (C1.13) Bacillus lactis, (C1.14) Bacillus rus, optionally strain AQ746 (Accession No. NRRL laterosporus, (C1.15) Bacillus lentimorbus, (C1.16) B-21618), (C1.59) Pseudomonas cepacia (ex Burk Bacillus licheniformis, optionally strain SB3086, (C1. holderia cepacia), (C1.60) Bacillus nematocida, 17) Bacillus medusa, (C1.18) Bacillus megaterium, optionally strain B-16, (C1.61) Bacillus circulars, (C1. (C1.19) Bacillus metiens, (C1.20) Bacillus natto, (C1. 62) Brevibacillus laterosporus (also known as Bacillus 21) Bacillus nigrificans, (C1.22) Bacillus popillae, laterosporus), optionally strain ATCC 64 or strain NRS (C1.24) Bacillus siamensis, (C1.25) Bacillus sphaeri 1111 or Strain NRS 1645 or Strain NRS 1647 or Strain cus, optionally Serotype H5a5b strain 2362. (C1.26) BPM3 or strain G4 or strain NCIMB 41419, (C1.63) Bacillus subtilis var. amyloliquefaciens strain FZB24, Corynebacterium paurometabolum, (C1.64) Lactoba (C1.27) Bacillus thuringiensis, optionally (C1.27a) cillus acidophilus, (C1.65) Paenibacillus alvei, option Bacillus thuringiensis var. israelensis (serotype H-14), ally strain T36 or strain III3DT-1A or strain 1112E or optionally strain AM65-52 (Accession No. ATCC strain 46C3 or strain 2771. (C1.66) Paenibacillus mac 1276) or strain BMP 144, (C1.27b) Bacillus thuringi erans, (C1.67) Pasteuria nishizawae, optionally strain ensis subsp. aizawai strain ABTS-1857 or strain GC-91 Pnl (C1.68) Pasteuria ramosa, (C1.69) Pasteuria thor (Accession No. NCTC 11821), or serotype H-7, or nei, (C1.70) Pseudomonas aeruginosa, optionally (C1.27c) Bacillus thuringiensis subsp. kurstaki strain strains WS-1 or PN1, (C1.71) Pseudomonas aureofa HD-1, or strain BMP 123, or strain ABTS 351 (Acces ciens, optionally strain TX-1, (C1.72) Pseudomonas sion No. ATCC SD-1275), or strain PB 54 (Accession fluorescens, optionally strain A506, (C1.73) Pseudomo No. CECT 7209), or strain SA 11 (Accession No. nas putida, (C1.74) Pseudomonas resinovorans, (C1. NRRL B-30790), or strain SA 12 (Accession No. 75) Pseudomonas Syringae, optionally strain MA-4, NRRL B-30791), or strain EG 2348 (Accession No. (C1.76) Serratia marcescens, optionally strain SRM NRRL B-18208) or (C1.27d) Bacillus thuringiensis (MTCC8708) or strain R35, (C1.77) Streptomyces can subsp. tenebrionis strain NB 176 or (C1.27e) Bacillus didus, optionally strain Y21007-2, (C1.78) Streptomy thuringiensis subsp. morrisoni or (C1.270 Bacillus ces lydicus, in particular strain WYCD108 or strain thuringiensis var. San diego or (C1.27g) Bacillus WYEC108, (C1.79) Streptomyces saraceticus, (C1.80) thuringiensis Subsp. thuringiensis (serotype 1) Zo Streptomyces venezuelae, (C1.81) Xenorhabdus nem MPPL002, or (C1.27h) Bacillus thuringiensis var. atophila, (C1.82) Agrobacterium radiobacter, (C1.83) aegyptii, or (C1.27k) Bacillus thuringiensis var. Bacillus mojavensis, optionally strain CECT-7666, collmeri, or (C1.271) Bacillus thuringiensis var. darm (C1.84) Pantoea agglomerans, optionally strain E325, Stadiensis, or (C1.27m) Bacillus thuringiensis var. den (C1.85) Streptomyces colombiensis, (C1.86) Strepto drolimus, or (C1.27n) Bacillus thuringiensis var. gal myces sp. WYE 20 (KCIC 0341 BP) and WYE 324 leriae, or (C1.27o) Bacillus thuringiensis var. (KCTC 0342BP), (C1.87) Bacillus brevis (also known japonensis, in particular strain Buibui or (C1.27r) as Brevibacillus brevis), optionally strain SS86-3 or Bacillus thuringiensis var. 7216, or (C1.27s) Bacillus strain SS86-4 or strain SS86-5 or strain 2904, (C1.88) thuringiensis var. T36, or (C1.27t) Bacillus thuringi Erwinia carotovora (also known as Pectobacterium ensis strain BDi32 (Accession No. NRRL B-21530), or carotovorum), (C1.89) Xanthomonas campestris pV (C1.27u) Bacillus thuringiensis strain AQ52 (Acces vesicatoria, (C1.90) Pasteuria reniformis, optionally sion No. NRRL B-21619), or (C1.27v) Bacillus strain Pr3, (C1.91) Burkholderia spec strain), (C1.92) thuringiensisstrain CR-371 (Accession No. ATCC Bacillus firmus CNCM I-1582, optionally the spores, 55273), (C1.28) Bacillus uniflagellatus, (C1.29) Delftia (C1.93) Bacillus cereus (synonyms: Bacillus endo acidovorans, optionally strain RAY209, (C1.30) Lyso rhythmos, Bacillus medusa), optionally spores of Bacil bacter antibioticus, optionally strain 13-1, (C1.31) Pas lus cereus strain CNCMI-1562, or strain BP01 (ATCC teuria penetrans (synonym Bacillus penetrans), (C1. 55675), (C1.94) Bacillus amyloliquefaciens strain 32) Pseudomonas chlororaphis, optionally strain MA IN937a or strain FZB42 (DSM 231179), or strain B3, 342 or strain 63-28, (C1.33) Pseudomonas proradix, or strain D747. (C1.95) Bacillus subtilis, optionally (C1.34) Streptomyces galbus, optionally strain K61 strain GB03 (Accession No. ATCC SD-1397) or strain (Accession No. DSM 7206) or strain NRRL 30232, QST713/AQ713 (Accession No. NRRL B-21661) or (C1.35) Streptomyces griseoviridis, (C1.36) Bacillus strain AQ 153 (ATCC accession No. 55614) or strain US 2016/0286803 A1 Oct. 6, 2016 68

AQ743 (Accession No. NRRL B-21665) or strain DB CG128 and VA9101 (C2.14) Paecilomyces lilacinus, 101, or strain DB 102, or strain MBI 600, or strain optionally spores of P lilacinus strain 251 (AGAL QST30002/AO30002 (Accession No. NRRL B-50421) 89/030550), (C2.15) Paecilomyces fumosoroseus (also or strain QST30004/AQ30004 (Accession No. NRRL known as Isaria fumosorosae), optionally strain apopka B-50455), (C1.96) Bacillus pumilus, optionally strain 97 (ATCC 20874), (C2.16) Penicillium bilaii, option GB34 (Accession No. ATCC 700814) or strain ally strain ATCC22348, (C2.17) Pichia anomala, QST2808 (Accession No. NRRL B-30087), or strain optionally strain WRL-076, (C2.18) Pseudozyma floc BU F-33, or strain AQ717 (Accession No. NRRL culosa, optionally strain PF-A22 UL, (C2.19) Pythium B21662), (C1.97) Pasteuria sp., optionally strain oligandrum, optionally strain DV74 or strain M1 SD-5832 and (C1.98) Pasteuria sp., optionally strain (ATCC 38472), (C2.20) Trichoderma asperellum, PTA-9643, (C1.98) Agrobacterium radiobacter, optionally strain K84 or strain K1026, (C1.99) Agro optionally strain ICC 012 (also known as Trichoderma bacterium vitis, optionally non-pathogenic strain harzianum ICC012) or strain SKT-1 or strain T34 or VAR03-1, (C1.100) Azorhizobium caulinodans, strain SFO4 or strain TV 1 (also known as Trichoderma optionally strain ZB-SK-5. (C1.101) Azospirillum ama viride TV 1) or strain T11 (also known as Trichoderma zonense, (C1.102) Azospirillum brasilense, (C1.103) viride T25), (C2.21) Trichoderma harzianum, option Azospirillum halopraeference, (C1.104) Azospirillum ally Tharzianum T39 or strain T-22, or strain TH 35 or strain TSTh20/PTA-0317 or strain 1295-22, (C2.22) irakense, (C1.105) Azospirillum lipoferum, (C1.106), Beauveria brongniartii, (C2.23) Aschersonia aley Azotobacter chroococcum, optionally strain H 23 rodes, (C2.24) Hirsutella thompsoni, (C2.25) Lagen (CECT 4435), (C1.107) Azotobacter vinelandii, idium giganteum, (C2.26) Myrothecium verrucaria optionally strain ATCC 12837, (C1.108) Bacillus aci strain AARC-0255, (C2.27) Pandora delphacis, (C2. docaldarius, (C1.109) Bacillus acidoterrestris, (C1. 28) Tsukamurella paurometabola, optionally strain 110) Bacillus alcalophilus, (C1.111) Bacillus alvei, C-924, (C2.30) ARF 18 (Arkansas Fungus 18), (C2.31) (C1.112) Bacillus aminoglucosidicus, (C1.113) Bacil Trichoderma atroviride optionally strain CNCM lus aminovorans, (C1.114) Bacillus amylolyticus (also 1-1237 or Strain NMI No. VO870O2387 or Strain NMI known as Paenibacillus amylolyticus), (C1.115) Bacil No. V08/002389 or Strain NMI No. V08/002390 or lus aneurinolyticus, (C1.116) Bacillus subtilis isolate Strain NMI No. V08/002388 or Strain ATCC 20476 B246.(C1.117) Bacillus tequilensis, optionally strain (IMI 206040) or strain T11 (IM1352941) or strain NII-094, (C1.118) Bacillus sp. strain AQ175 (ATCC LC52 or strain NMI V08/002387, or strain NMI V08/ Accession No. 55608), (C1.119) Bacillus sp. strain OO2389 or Strain SKT-1 (FERMP-1651 or Strain SKT AQ177 (ATCC Accession No. 55609), (C1.120) Bacil 2/FERM P-16511 or Strain SKT-3/FERMP-17021 or lus sp. strain AQ178 (ATCC Accession No. 53522), strain L52. (C2.32) Glomus aggregatum, (C2.33) Glo (C1.121) Gluconacetobacter diazotrophicus, (C1.122) mus etunicatum, (C2.34) Glomus intraradices, (C2.35) Herbaspirilum rubrisubalbicans, (C1.123) Herbaspiri Glomus mosseae, (C2.36) Glomus deserticola, (C2.37) lum seropedicae, (C1.124) Lactobacillus sp., (C1.125) Glomus clarum, (C2.38) Glomus brasilianum, (C2.39) Lysobacter enzymogenes, optionally strain C3. (C1. Glomus monosporum, (C2.40) Gigaspora margarita, 126) Rhodococcus globerulus strain AQ719 (Accession (C2.41) Rhizopogon villosullus, (C2.42) Rhizopogon. No. NRRL B21663), (C1.127) Streptomyces sp. Strain luteolus, (C2.43) Rhizopogon. amylopogon, (C2.44) NRRL B-301.45, (C1.128) Streptomyces acidiscabies, Rhizopogon fulvigleba, (C2.45) Pisolithus tinctorius, optionally strain RL-110T, (C1.129) Streptomyces gos (C2.46) Scleroderma cepa, (C2.47) Scleroderma citri hikiensis, (C1.130) Streptomyces lavendulae, (C1.131) num, (C2.48) Suillus granulatus, (C2.49) Suillus punc Streptomyces prasinus, (C1.132) Streptomyces rimo tatapies, (C2.50) Laccaria laccata, (C2.51) Laccaria StiS, bicolor (C2.52) Metarhizium flavoviride, (C2.53) (C2) fungi or yeasts selected from the group consisting of Arthrobotry's dactyloides, (C2.54) Arthrobotry's oli (C2.1) Ampelomyces quisqualis, optionally strain AQ gospora, (C2.55) Arthrobotry's superba (C2.56) Asper 10, (C2.2) Aureobasidium pullulans, optionally blas gillus flavus strain NRRL 21882 or strain AF36, (C2. tospores of strain DSM14940 or blastospores of strain 57) Candida Saitoana, optionally strain NRRL DSM 14941 or mixtures thereof, (C2.3) Beauveria Y-21022. (C2.58) Chaetomium cupreum, (C2.59) bassiana, optionally strain ATCC 74040 or strain GHA Chaetomium globosum, (C2.60) Chondrostereum pur or strain ATP02 (DSM 24665) or strain CG716, (C2.4) pureum, in particular strain PFC2139, (C2.61) Cla Candida oleophila, optionally strain 0 or strain 1-182, dosporium cladosporioides strain H39, (C2.62) Con (C2.5) Coniothyrium minitans, optionally strain CON/ idiobolus obscurus, (C2.63) Cryptococcus albidus, M/91-8 (DSM-96.60), (C2.6) Dilophosphora alopecuri, (C2.64) Cryptococcus flavescens, optionally strain (C2.7) Gliocladium catenulatum, optionally strain NRRL Y-50378 and strain NRRL Y-50379, (C2.65), J1446, (C2.8) Lecanicillium lecanii (formerly known Dactylaria candida, (C2.66) Entomophthora virulenta, as Verticillium lecanii), optionally conidia of strain (C2.67) Harposporium anguillullae, (C2.68) Hirsutella KV01 or strain DAOM198499 or DAOM216596, (C2. minnesotensis, (C2.69) Hirsutella rhossiliensis, (C2. 9) Metarhizium anisopliae, optionally strain F52 (DSM 70) Meristacrum asterospermum, (C2.71) Microd 3884, ATCC 90448) or var. acridum isolate IMI ochium dimerum, optionally strain L13, (C2.72) Mona 330189/ARSEF 7486, (C2.10) Metschnikovia fructi Crosporium cionopagum, (C2.73) Monacrosporium cola, optionally the strain NRRL Y-30752, (C2.11) psychrophilum, (C2.74) Monacrosporium drechsleri, Microsphaeropsis ochracea, (C2.12) Muscodor albus, (C2.75) Monacrosporium gephyropagum, (C2.76) optionally strain QST 20799, (C2.13) Nomuraea rileyi, Ophiostoma piliferum, optionally strain D97. (C2.77) optionally strains SA86101, GU87401, SR86151, Paecilomyces variotii, optionally strain Q-09, (C2.78) US 2016/0286803 A1 Oct. 6, 2016 69

Pochonia chlamydosporia (= Vercillium chlamydospo Tetrameres spp., (C5.19) Acuaria spp., (C5.20) Gongy riumi), (C2.79) Pseudozyma aphidis, (C2.80) Stagono lonema spp., (C5.21) Protrellatus spp., (C5.22) spora heteroderae, (C2.81) Stagonospora phaseoli, Hydromermis spp., (C5.23) Cameronia spp., (C5.24) (C2.82) Talaromyces flavus, optionally strain V117b, Physaloptera spp., (C5.25) Chitwoodiella ovo?ila (C2.83) Trichoderma viride (also known as menta, (C5.26) Gynopoecilia pseudovipara, (C5.27) Trichoderma gamsii), optionally strain ICC 080 and Parasity lenchus spp., (C5.28) Neoparasity lenchus strain TV1, (C2.84) Trichoderma harmatum, isolate rugulosi, (C5.29) Sulphuretvlenchus elongatus, (C5. 382, (C2.85) Trichoderma koningii, (C2.86) 30) Sphaerulariopsis spp., (C5.31) Allantonema spp., Trichodermalignorum, (C2.87) Trichoderma polyspo (C5.32) Contortvlenchus spp., (C5.33) Bovienema spp., rum, isolate IMI 206039 (ATCC 20475), (C2.88) (C5.34) Parasitaphelenchus spp., (C5.35) Parasito Trichoderma stromaticum, (C2.89) Trichoderma virens rhabditis spp., (C5.36) Phasmarhabditis hermaphro (also known as Gliocladium virens), optionally strain dita, (C5.37) Romanomermis spp., (C5.38) Octomyo GL-21 or strain G41, (C2.90) Ulocladium oudemansii, mermis spp., (C5.39) Strelkovimermis peterseni, (C5. optionally strain HRU3, (C2.91) Verticillium albo 40) Perutilimermis culicis, (C5.41) Culicinermis spp., atrum, optionally strain WCS850, (C2.92) Verticallum (C5.42) Empidomermis spp., (C5.43) Gastromermis chlamydosporium, (C2.93) Verticillium dahlia isolate spp., (C5.44) Isomermis spp., (C5.45) Neomesomermis WCS 850, (C2.94) Zoophtora radicans, (C2.95) Cylin spp., (C5.46) Limnomermis spp., (C5.47) Mesomermis drocarpon heteronema, (C2.96) Exophiala jeanselmei, spp., (C5.48) Xenorhabdus luminescence (ento (C2.97) Exophilia pisciphila, (C2.98) Fusarium asper mopathogenic bacteria symbiotically associated with gilus, (C2.99) Fusarium oxysporum, optionally non nematodes): (C5.49) Heterorhabditis bacteriophora, pathogenic strain Fo47 or non pathogenic strain 251/ (C5.50) Heterorhabditis baujardi, (C5.51) Heterorhab 2RB, (C2.100) Fusarium solani, optionally strain Fs-K, ditis indica, (C5.52) Heterorhabditis marelatus, (C5. (C2.101) Gliocladium roseum, optionally strain 321U, 53) Heterorhabditis megidis, (C5.54) Heterorhabditis (C2.102) Mucor haemelis, (C2.103) Nematoctonus Zealandica, (C5.55) Phasmarhabditis hermaphrodita, geogenius, (C2.104) Nematoctonus leiosporus, (C2. (C5.56) Steinernema bibionis, (C5.57) Steinernema 105) Phlebiopsis gigantea, (C2.106) Trichoderma glaseri, (C5.58) Steinernema kraussei, (C5.59) Stein album, (C2.107) Trichoderma asperellum, (C2.108) ernema riobrave, (C5.60) Steinernema scapterisci, Trichoderma gamsii or optionally strain ICC080, (C2. (C5.61) Steinernema scarabaei, (C5.62) Steinernema 109) Hirsutella citriformis, (C2.110) Muscodor roseus siamkayai, (C5.63) Beddingia (Deladenus) Siridicola, strain A3-5 (Accession No. NRRL 30548), (C2.111) (C5.64) Filipjevimermis leipsandra, (C5.65) Stein Neocosmospora vasinfecta, (C2.112) Penicillium ver ernema thailandse, miclatum, (C2.113) Saccharomyces cerevisae, option (C6) Inoculants selected from the group consisting of ally strain CNCM No. 1-3936, strain CNCM No. (C6.1) Rhizobium leguminosarum, optionally by. 1-3937, strain CNCM No. 1-3938, strain CNCM No. viceae strain Z25 (Accession No. CECT 4585), (C6.2) 1-3939, (C2.114) Sporothrix insectorum, Rhizobium tropici, (C6.3) Rhizobium loti, (C6.4) Rhizo (C3) Protozoas selected from the group consisting of bium trifolii, (C6.5) Rhizobium meliloti, (C6.6) Rhizo (C3.1) Nosema locustae, (C3.2) Thelohania, (C3.3) bium fredii, (C6.7) Azorhizobium caulinodans, (C6.8) Vairimorpha, Pseudomonas, (C6.9) Azospirillum, (C6.10) Azoto (C4) Viruses selected from the group consisting of (C4.1) bacter, (C6.11) Streptomyces, (C6.12) Burkholdia, (C6. Gypsy moth (Lymantria dispar) nuclear polyhedrosis 13) Agrobacterium, (C6.14) Endo Mycorhiza, (C6.15) virus (NPV), (C4.2) Tussock moth (Lymantriidae) Ecto Mycorhiza, (C6.16) Vesicular Arbuscular (VA) NPV. (C4.3) Heliothis NPV. (C4.4) Pine sawfly (Neo Mycorhiza, (C6.17) Bradyrhizobium, diprion) NPV. (C4.5) Codling moth (Cydia pomonella) (C7) Botanicals or plant extracts selected from the group granulosis virus (GV), (C4.6) Adoxophyes Orana GV. consisting of (C7.1) Thymus oil, (C7.2) Azadirachtin (C4.7) Helicoverpa armigera NPV. (C4.8) Spodoptera (Neem), (C7.3) Pyrethrum, (C7.4) Cassia nigricans, exigua NPV. (C4.9) Spodoptera littoralis NPV. (C4.10) (C7.5) Quassia amara, (C7.6) Rotenon, (C7.7) Garlic, Spodoptera litura NPV. (C4.11) Neodiprion abietis (C7.8) Quillaja, (C7.9) Sabadilla, optionally-Veratrin, NPV. (C4.12) Neodiprion sertifer NPV. (C4.13) Agrotis (C7.10) Ryania, optionally Ryanodine, (C7.11) Viscum segetum (turnip moth) nuclear polyhedrosis virus album (mistel), (C7.12) mugwort or common tansy (NPV), (C4.14) Anticarsia gemmatalis (Woolly pyrol (Tanacetum vulgare), (C7.13) Artemisia absinthium, moth) mNPV. (C4.15) Autographa Californica (Alfalfa (C7.14) Urtica dioica, (C7.15) Symphytum officinale, Looper) mNPV; (C7.16) Tropaeulum majus, (C7.17) Quercus (C7.18) (C5) entomopathogenic nematodes selected from the mustard flour, (C7.19) Chenopodium anthelminticum, group consisting of (C5.1) Steinernema ssp. (C7.20) Dryopteris filix-mas, (C7.21) bark of Chinese ( Neoaplectana spp.), (C5.2) Steinernema Scapterisci, bittersweet (Celastrus orbiculatus), (C7.22) Equisetum (C5.3) Steinernema feltiae ( Neoplectana Carpocap arvense, (C7.23) bark of Celastus angulatus, (C7.24) sae, (C5.4) Steinernema carpocapsae, (C5.5) Heter Laminarin (Brown Algae), (C7.25) Alginic acid orhabditis spp., (C5.6) Heterorhabditis heliothidis, (Brown Algae), (C7.26) Chitin/Chitinosan, (C7.27) (C5.7) Hexamermis spp., (C5.8) Amphimermis spp., Chenopodium quinoa, (C7.28) Melaleuca alternifolia (C5.9) Mermis nigrescens, (C5.10) Agamermis decau and (C7.30) natural extracts or simulated blend of data, (C5.11) Maupasinaweissi, (C5.12) Subulura spp., Chenopodium ambrosioides, (C5.13) Seuratum cadarachense, (C5.14) Pterygoder C8) Products pproduced byy microorganisms9. includin9. matites spp., (C5.15) Abbreviata caucasica, (C5.16) proteins or secondary metabolites selected from the Spirura guianensis, (C5.17) Diplotriaena spp., (C5.18) group consisting of (C8.1) Harpin. US 2016/0286803 A1 Oct. 6, 2016 70

5. Composition comprising an active compound combi nation according to claim 1 and further comprising at least one of an auxiliary, Solvent, carrier, Surfactant and/or extender. 6. Method for controlling insects, nematodes or phyto pathogens comprising applying an active compound com bination according to claim 1 to seed, a plant, to fruit of a plant and/or to Soil on which a plant grows and/or is Supposed to grow. 7. Method according to claim 6, wherein the plant, the fruit of the plant and/or the soil on which the plant grows and/or is intended to grow is treated. 8. Method according to claim 6, wherein, in treatment of leaves, from 0.01 to 10 000 g/ha is employed and in the treatment of seed, from 2 to 200 g per 100 kg of seed is employed. 9. An active compound combination according to claim 1 capable of being used for controlling one or more of insects, nematodes and/or phytopathogens in crop protection. 10. An active compound combination according to claim 1 capable of being used for treating seed, seed of a trans genic plant and/or a transgenic plant. 11. Seed treated with an active compound combination according to claim 1. 12. Method of treating a plant comprising applying an active compound combination according to claim 1 for improvement of plant properties comprising one or more of better growth or increased harvest yields or a better devel oped root system or a larger leaf area or greener leaves or stronger shoots.