Anti-CRK Monoclonal Antibody, Clone 4H22D2 (DCABH-1226) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

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Anti-CRK monoclonal antibody, clone 4H22D2 (DCABH-1226) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Mouse monoclonal to Crk p38 Antigen Description The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. Immunogen Purified recombinant fragment of Human Crk p38 expressed in E. Coli. Isotype IgG2b Source/Host Mouse Species Reactivity Mouse, Human Clone 4H22D2 Purity Ascites Conjugate Unconjugated Applications WB, ELISA, IHC-P, Flow Cyt, ICC/IF Positive Control Recombinant Crk p38 protein; Crk p38-hIgGFc transfected HEK293 cell lysate; Human rectum cancer and bladder cancer tissues; MCF7 and 3T3 L1 cells. Format Liquid Size 100 μl Buffer Preservative: 0.03% Sodium azide; Constituent: 99% Ascites Preservative 0.03% Sodium Azide Storage Store at 4°C or at -20°C for long term storage. GENE INFORMATION 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Gene Name CRK v-crk sarcoma virus CT10 oncogene homolog (avian) [ Homo sapiens ] Official Symbol CRK Synonyms CRK; v-crk sarcoma virus CT10 oncogene homolog (avian); v crk avian sarcoma virus CT10 oncogene homolog; adapter molecule crk; proto-oncogene c-Crk; p38; CRKII; FLJ38130; Entrez Gene ID 1398 Protein Refseq NP_005197 UniProt ID P46108 Chromosome Location 17p13 Pathway ARMS-mediated activation, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Function SH2 domain binding; SH3/SH2 adaptor activity; ephrin receptor binding; protein binding; protein phosphorylated amino acid binding; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.

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