Anti-CRK Monoclonal Antibody, Clone 4H22D2 (DCABH-1226) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-CRK monoclonal antibody, clone 4H22D2 (DCABH-1226) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse monoclonal to Crk p38

Antigen Description The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4.

Immunogen Purified recombinant fragment of Human Crk p38 expressed in E. Coli.

Isotype IgG2b

Source/Host Mouse

Species Reactivity Mouse, Human

Clone 4H22D2

Purity Ascites

Conjugate Unconjugated

Applications WB, ELISA, IHC-P, Flow Cyt, ICC/IF

Positive Control Recombinant Crk p38 protein; Crk p38-hIgGFc transfected HEK293 cell lysate; Human rectum cancer and bladder cancer tissues; MCF7 and 3T3 L1 cells.

Format Liquid

Size 100 μl

Buffer Preservative: 0.03% Sodium azide; Constituent: 99% Ascites

Preservative 0.03% Sodium Azide

Storage Store at 4°C or at -20°C for long term storage.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol CRK

Synonyms CRK; v-crk sarcoma virus CT10 oncogene homolog (avian); v crk avian sarcoma virus CT10 oncogene homolog; adapter molecule crk; proto-oncogene c-Crk; p38; CRKII; FLJ38130;

Entrez Gene ID 1398

Protein Refseq NP_005197

UniProt ID P46108

Chromosome Location 17p13

Pathway ARMS-mediated activation, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem;

Function SH2 domain binding; SH3/SH2 adaptor activity; ephrin receptor binding; protein binding; protein phosphorylated amino acid binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]