The University of Melbourne Walter and Eliza Hall Institute the Royal

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The University of Melbourne Walter and Eliza Hall Institute the Royal

Brunswick Rd Barkly St Park St Barkly St 0m 500m 1km Brunswick Rd Kilometers 21 Park St Poplar Rd Royal Park 10 Golf Course 20 Oak St Pigdon St Poplar Rd Royal Pde Pigdon St 24 Garton St Manningham St Melbourne Zoo Walker St Princes Royal Park Elliott Ave Park St Georges Rd Royal 09 Park The Avenue Princes Park Dr Ma cArthu r Rd Melbourne Lygon St Flemington Rd Elliott Ave Drummond St General Rathdowne St Cemetery Canning St Nicholson St C Brunswick St e St Georges Rd Royal Park South m e t e ry Rd Princes St Alexandra Pde 05 06 Flemington Rd Gatehouse St Park Dr Royal Pde Swanston St 10 Story St 01 Macaulay St + Elgin St Canning St 16 02 13 + 08 The University 27 28 of Melbourne Abbotsford St Harker St Johnston St 04 25 + 03 Courtney St 19 Arden 11 Grattan St Macaulay 26 + Barkly St Arden St 07 12 15 14 Carlton St Pelham St B a r r y Wreckyn St Dryburgh St S Queensberry St Leicester St t Bouverie St Swanston St Cardigan St Lygon St Elizabeth St Drummond St Curzon St Rathdowne St Carlton Gardens Nicholson St Brunswick St Victoria St Peel St K Smith St in Gertrude St g 18 S t HawkeS St 17 p e Spring St Ex n Chetwynd St c e hi Victoria St Adderley St r S biti t 22 + 29 La Trobe St Franklin St o 23 n St nsdale St Albert St Dudley St Melbourne CBD Lo 30 Victorian Comprehensive The National Ageing The University of Melbourne 01 11 Cancer Centre 21 Research Institute Peter Doherty Institute 02 Walter and Eliza Hall Institute 12 Centre for Eye Research Australia for Infection and Immunity 22 03 The Royal Melbourne Hospital 13 The Melbourne Brain Centre 23 Bionics Institute Monash Institute of Pharmaceutical 04 The Royal Women’s Hospital 14 Melbourne Bioinformatics 24 Science, Monash University (Parkville Campus) 05 The Royal Children’s Hospital 15 Biomedical Research Victoria 25 BioGrid Australia The Murdoch Children’s The Bio21 Molecular Science Australian Genome 06 Research Institute 16 and Biotechnology Institute 26 Research Facility Ltd 07 Peter MacCallum Cancer Centre 17 St Vincent’s Hospital Melbourne 27 Francis Perry House The Florey Institute of Neuroscience St Vincent's Institute 08 and Mental Health 18 of Medical Research 28 Melbourne Private Hospital The Royal Victorian CSIRO (Parkville) Dental Health Services Victoria 09 19 29 Eye and Ear Hospital CSL (Poplar Road and Orygen, the National Centre of Baker Heart and 10 Bio21 Institute campuses) 20 Excellence in Youth Mental Health 30 Diabetes Institute.

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Seizure Dynamics
Balson et al. BMC Neuroscience 2014, 15(Suppl 1):P152 http://www.biomedcentral.com/1471-2202/15/S1/P152 POSTERPRESENTATION Open Access Seizure dynamics: a computational model based approach demonstrating variability in seizure mechanisms Richard S Balson1,2,3,4*, Dean R Freestone1,2,3, Mark J Cook2,3, Anthony N Burkitt1,2,4, David B Grayden1,2,4 From The Twenty Third Annual Computational Neuroscience Meeting: CNS*2014 Québec City, Canada. 26-31 July 2014 Epilepsy is a neurological disorder that affects approxi- animals, based upon recorded LFP 150 seconds prior to mately 1% of the world’s population. At present, the and post seizure, as well as during the seizure. The esti- underlying mechanisms involved in seizure generation mation results show that, for three of the four animals, and termination are not fully understood. A computa- the mechanisms involved in their seizures are similar. tional model-based approach to provide further insights For the fourth animal, the estimated physiology prior to, into physiological changes occurring in the brain prior during, and post seizure vary drastically. When compar- to, during, and post seizure is presented. We demon- ing the physiological dynamics between animals, we strate that an unscented Kalman filter [1] can be used found that the estimation results predicted that there to fit physiological parameters of a neural mass model are different mechanisms involved in seizure initiation, [2] to recorded EEG. This technique elucidates physiolo- evolution, and termination in each animal. The common gical changes in recorded EEG that cannot be deter- element in all the results, except for a single estimated mined with standard EEG analysis methods.
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Low Resolution
Australian Biochemist The Magazine of the Australian Society for Biochemistry and Molecular Biology Inc. August 2019, Volume 50, Number 2 VOLISSN 50 NO 2 AUGUST 1443-0193 2019 AUSTRALIAN BIOCHEMIST PAGE 1 Be inspired during the 3- da y progra m including a fa nta stic lineup of industry lea ding interna tiona l plena ry spea kers, a nd hea r from our society specia lty lectures, be enga ged with poster presenta tions a nd lea rn a t the E/MCR mini- symposium. For more informa tion on our spea kers, progra m a nd to register, visit our website www.a sbmb2019.com.a u REGISTER NOW! PAGE 2 AUSTRALIAN BIOCHEMIST VOL 50 NO 2 AUGUST 2019 Table of Contents 4 Editorial Committee 5 Editorial 7 Publications with Impact Distinct Mechanisms Govern Recognition of Viral and Host Ligands by an Innate Immune Receptor Buying Time for Contractile Signaling Genetic Stutters, Gut Feelings and Neurodegenerative Disease 11 Off the Beaten Track Why it Sometimes Pays to Work for Money 14 ASBMB Education Feature Glycogen Builder: the Game Making a Drama Out of Biochemistry From the Whiteboard to the Conference: Scaffolding Conference-style Poster Presentations 18 SDS Page The Importance of Blue Sky Research 19 Competition: Unscramble 20 ASBMB 2019 International Plenary Speaker Profiles 22 ASBMB 2019 Symposium Speakers 23 Melbourne Protein Group: an ASBMB Special Interest Group 24 ASBMB Shimadzu Education Award Report 26 Intellectual Property Patenting Inventions in the Microbiome Space 29 Queen’s Birthday Honours for ASBMB Members 31 ASBMB Awards 2020 33 Election of Council 2020 33 Annual General Meeting of ASBMB 34 New ASBMB Members 35 Forthcoming Meetings 36 Our Sustaining Members 41 ASBMB Council 42 Directory Front Cover Bachelor of Biomedicine students from the University of Melbourne participating in an acting skills workshop with Rinske Ginsberg, VCA Theatre, as part of the Performing Sciences program, where students devise short performances embodying biochemical concepts.
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Improving Outcomes of Deep Brain Stimulation for Essential Tremor with Motion Tracking and Speech Analysis
IETF Grant Proposal: 27 February 2015 Improving Outcomes of Deep Brain Stimulation for Essential Tremor with Motion Tracking and Speech Analysis Brief Summary Deep Brain Stimulation (DBS) is a common form of treatment for medically refractory essential tremor (ET). DBS consists of one or two small electrode arrays that are placed in specific brain targets by a trained neurosurgeon. Controlled electrical pulses are then sent to these electrodes by a neuro- stimulator to modify brain activity and provide therapeutic benefit. The characteristics (duration, amplitude, and frequency) of these pulses must be set to minimize tremor, yet prevent unwanted side- effects such as speech difficulties. Usually, these parameters are set by a neurologist based on their observation of tremor and side-effect. In general, the ventral intermediate nucleus (VIM) of the brain is considered the most appropriate target for stimulation. Recently, however, the posterior subthalamic area (PSA) was also discovered to be an effective stimulation target. Since this discovery, much debate has ensued regarding which is the better target in terms of tremor and side-effect reduction. For each target, the stimulation level must also be considered due to influence on implant battery life. In this study we aim to determine which of the two targets provides the best outcome to the patient using novel methods to quantify tremor and side- effect. The majority of clinical assessments of ET rely on clinical scores based on observation. These are subjective measures influenced by the clinician’s opinion and experience. Unfortunately, the accuracy and sensitivity of such measures can be inadequate. To improve assessment of ET, we have developed our own method of tremor measurement based on electronic motion tracking.
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Pfcerli1 Is a Conserved Rhoptry Associated Protein Essential for Plasmodium Falciparum Merozoite Invasion of Erythrocytes
ARTICLE https://doi.org/10.1038/s41467-020-15127-w OPEN PfCERLI1 is a conserved rhoptry associated protein essential for Plasmodium falciparum merozoite invasion of erythrocytes Benjamin Liffner 1,8, Sonja Frölich 1,8, Gary K. Heinemann2, Boyin Liu3, Stuart A. Ralph 3, ✉ Matthew W.A. Dixon 3, Tim-Wolf Gilberger4,5,6 & Danny W. Wilson 1,7 1234567890():,; The disease-causing blood-stage of the Plasmodium falciparum lifecycle begins with invasion of human erythrocytes by merozoites. Many vaccine candidates with key roles in binding to the erythrocyte surface and entry are secreted from the large bulb-like rhoptry organelles at the apical tip of the merozoite. Here we identify an essential role for the conserved protein P. falciparum Cytosolically Exposed Rhoptry Leaﬂet Interacting protein 1 (PfCERLI1) in rhoptry function. We show that PfCERLI1 localises to the cytosolic face of the rhoptry bulb membrane and knockdown of PfCERLI1 inhibits merozoite invasion. While schizogony and merozoite organelle biogenesis appear normal, biochemical techniques and semi-quantitative super- resolution microscopy show that PfCERLI1 knockdown prevents secretion of key rhoptry antigens that coordinate merozoite invasion. PfCERLI1 is a rhoptry associated protein iden- tiﬁed to have a direct role in function of this essential merozoite invasion organelle, which has broader implications for understanding apicomplexan invasion biology. 1 Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia. 2 Experimental Therapeutics Laboratory, School of Pharmacy and Medical Sciences, University of South Australia Cancer Research Institute, Adelaide, SA 5005, Australia. 3 Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.
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Melbourne Biomedical Precinct Studley Rd to an Exceptional Network Economic and Investment Growth Swinburne University of of Skilled Workers, Quality for the State
The Royal Children’s Hospital + The Murdoch Children’s Research Institute The Royal Women’s Hospital Darwin Walter & Eliza Hall Institute Monash Institute of Pharmaceutical NT Science, Monash University + CSIRO QLD Royal Melbourne Hospital WA Brisbane C Florey Institute SA e m ete ry Rd The University of Melbourne NSW Perth Sydney A Precinct approach Victorian Comprehensive Cancer Centre Adelaide Royal Pde Canberra + Peter MacCallum Cancer Centre The Doherty Institute to collaboration Flemington Rd Elgin St St Vincent’s Hospital Melbourne Hobart Melbourne, Grattan St Swanston St Australia and innovation Arden St Curzon St Elizabeth St Lygon St La Trobe University Queensberry St d R g r e b Burgundy St Rathdowne St l Chetwynd St Victoria St e > id e Melbourne Brain Centre H r Peel St e Austin Health p Plan Melbourne, Victoria’s key metropolitan Franklin St p Melbourne has biomedical La Trobe St U Austin Hospital planning strategy, highlights the precincts Banksia St capabilities unparalleled in around Melbourne, Monash, Deakin, Olivia Newton-John Australia and amongst the and La Trobe universities as clusters CSL Cancer Wellness & world’s best. We are home which offer signiﬁcant opportunities (Poplar Road) Research Centre for innovation as well as employment, Melbourne Biomedical Precinct Studley Rd to an exceptional network economic and investment growth Swinburne University of of skilled workers, quality for the state. Technology education providers, leading The Melbourne Biomedical Precinct Deakin University St Kilda Rd research institutes and a Partners are largely collocated to the Princes Hwy Commercial Rd Burwood & Geelong Campuses sophisticated health system. north of Melbourne’s CBD close to Monash University, Australia’s highest ranking university, Clayton � Caulﬁeld There is a growing body of evidence the University of Melbourne.
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2010-2011 Annual Report
Annual Report 2010-2011 Mastery of disease through discovery | www.wehi.edu.au Contents 1 About the institute 3 Director’s and Chairman’s report 5 Discovery 8 Cancer and Haematology 10 Stem Cells and Cancer 12 Molecular Genetics of Cancer 14 Chemical Biology 16 Molecular Medicine 18 Structural Biology 20 Bioinformatics 22 Infection and Immunity 24 Immunology The Walter and Eliza Hall Institute 26 Autoimmunity and Transplantation of Medical Research 28 Cell Signalling and Cell Death 1G Royal Parade 30 Inﬂammation Parkville Victoria 3052 Australia Telephone: (+61 3) 9345 2555 32 Molecular Immunology Facsimile: (+61 3) 9347 0852 34 Publications WEHI Biotechnology Centre 36 Awards 4 Research Avenue 37 Translation La Trobe R&D Park Bundoora Victoria 3086 Australia Translating our research 38 Telephone: (+61 3) 9345 2200 40 Developing our research Facsimile: (+61 3) 9345 2211 42 Patents www.wehi.edu.au www.facebook.com/WEHIresearch 43 Education www.twitter.com/WEHI_research 46 2010-11 graduates ABN 12 004 251 423 47 Seminars Acknowledgements 48 Institute awards Produced by the institute’s Community Relations department 49 Engagement Managing editor: Penny Fannin Editor: Liz Williams 51 Strategic partners Writers: Liz Williams, Vanessa Solomon and Julie Tester 52 Scientiﬁc and medical community Design and production: Simon Taplin Photography: Czesia Markiewicz and Cameron Wells 54 Public engagement 57 Engagement with schools Cover image 58 Donor and bequestor engagement Art in Science finalist 2010 Vessel webs 59 Sustainability Dr Leigh Coultas, Cancer and Haematology division 60 The Board This image shows the delicate intricacy in the developing eye of a transient population of web-like blood vessels.
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Survey of Commercial Outcomes from Public Research (Scopr) 2019 Report
techtransfer.org.au SURVEY OF COMMERCIAL OUTCOMES FROM PUBLIC RESEARCH (SCOPR) 2019 REPORT Survey and report delivered by FOREWORD There is an ever-present imperative to capture the commercial value of our research endeavour for our future wellbeing. To do so strategically, decision makers from laboratory, institutional and government levels need insights into how the research sector is currently engaging with industry to transfer knowledge and innovation, and thereby deliver benefits to our society from the fruits of our research. For many years in Australia there has been a focus on improving innovation metrics, thus I am delighted to acknowledge the initiative of gemaker and Knowledge Commercialisation Australasia (KCA) in producing the inaugural Survey of Commercial Outcomes from Public Research (SCOPR). The SCOPR takes its lead from the National Survey of Research Commercialisation (NSRC) produced since 2000 by the Department of Industry, Science, Energy and Resources. To avoid duplication, the Department has decided to cease the NSRC and will work with KCA to share knowledge, and access data collected by SCOPR. As we face the COVID-19 pandemic, effective knowledge transfer is more important than ever, so I hope that this report will spur our research institutions to even greater achievements. Realising effective knowledge transfer will depend on having skilled commercialisation professionals who can help researchers turn great ideas into beneficial products and services. I applaud KCA’s support for technology transfer professionals
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Human DECR1 Is an Androgen-Repressed Survival Factor
RESEARCH ARTICLE Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis Zeyad D Nassar1,2†, Chui Yan Mah1,2†, Jonas Dehairs3, Ingrid JG Burvenich4, Swati Irani1,2, Margaret M Centenera1,2, Madison Helm1,2, Raj K Shrestha5, Max Moldovan2, Anthony S Don6, Jeff Holst7, Andrew M Scott4, Lisa G Horvath8, David J Lynn2,9, Luke A Selth1,5,9, Andrew J Hoy10, Johannes V Swinnen3, Lisa M Butler1,2* 1University of Adelaide Medical School and Freemasons Foundation Centre for Men’s Health, University of Adelaide, Adelaide, Australia; 2South Australian Health and Medical Research Institute, Adelaide, Australia; 3KU Leuven- University of Leuven, LKI- Leuven Cancer Institute, Department of Oncology, Laboratory of Lipid Metabolism and Cancer, Leuven, Belgium; 4Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, and School of Cancer Medicine, La Trobe University, Melbourne, Australia; 5Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide, Adelaide, Australia; 6NHMRC Clinical Trials Centre, and Centenary Institute, The University of Sydney, Camperdown, Australia; 7Translational Cancer Metabolism Laboratory, School of Medical Sciences and Prince of Wales Clinical School, UNSW Sydney, Sydney, Australia; 8Garvan Institute of Medical Research, NSW 2010; University of Sydney, NSW 2006; and University of New South Wales, Darlinghurst, Australia; 9College of Medicine and Public Health, Flinders University, Bedford Park, Australia; 10Discipline of Physiology, School of *For correspondence: Medical Sciences, Charles Perkins Centre, Faculty of Medicine and Health, The [email protected] University of Sydney, Camperdown, Australia †These authors contributed equally to this work Competing interests: The b authors declare that no Abstract Fatty acid -oxidation (FAO) is the main bioenergetic pathway in human prostate competing interests exist.
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University of Melbourne Annualreport2017 Fullreport
Annual Report 2017 unimelb.edu.au Contents Chancellor’s letter 1 VC’s introduction 2 The Melbourne Vision 3 Our past, present and future 4 2017 timeline 6 At a glance 8 Five-year statistics 10 Growing Esteem 12 Chapters in brief 14 Teaching, Learning and the Student Experience 16 Research 34 Engagement 48 Sustainability 64 Staff honours 78 High-achieving students 80 University governance 82 Council members 83 Academic governance 86 Governance structure 87 Senior leadership/University management 88 Statutory reporting 92 Financial report 105 Financial report index 106 Financial statement overview 107 Five-year financial summary 110 Financial statements 114 Disclosure index 166 Glossary 169 Index 171 | Front cover: ‘Eagle nest’, 2011, acrylic on canvas by Wurundjeri/Yorta Yorta artist and researcher, Ashley Kerr-Firebrace, is an intricate depiction of Wurundjeri creator Bunjil (the eagle) standing strong in the nest and supported by country, culture and people. The University of Melbourne stands on the land of the Wurundjeri people of the Kulin Nations. Ashley is the son of Wurundjeri Elder, Aunty Diane Kerr, who was born in Carlton, lives on Country and performs the Wominjeka (Welcome) to Country at University of Melbourne events and ceremonies. The Hon. Gayle Tierney MLC Minister for Training and Skills Level 1, 2 Treasury Place East Melbourne Vic 3002 16 March 2018 Dear Minister In accordance with the requirements of regulations and financial reporting directions under the Financial Management Act 1994, I am pleased to submit for your information and presentation to Parliament the Annual Report of the University of Melbourne for the year ending 31 December 2017.
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Fellowship of the Australian Academy of Health and Medical Sciences January 2019
FELLOWSHIP OF THE AUSTRALIAN ACADEMY OF HEALTH AND MEDICAL SCIENCES JANUARY 2019 Fellowship Year Name of Fellow Primary Position Primary Institution State Office Inducted Pro Vice Chancellor of Health and Medicine Professor John (Robert) Aitken Fellow 2015 The University of Newcastle NSW Laureate Professor of Biological Sciences Senior Staff Specialist The Children’s Hospital at Westmead Professor Ian Alexander Fellow 2015 NSW Head, Gene Therapy Research Unit Children’s Medical Research Institute Professor Warren Alexander Fellow 2015 Joint Head, Cancer and Haematology Division The Walter and Eliza Hall Institute of Medical Research VIC Professor Katie (Katrina) Allen Fellow 2015 Theme Director, Population Health Consultant Paediatrician Murdoch Children's Research Institute, The Royal Children’s Hospital VIC Professor Craig Anderson Fellow 2015 Senior Director, Neurological and Mental Health Division The George Institute for Global Health NSW Professor Vicki Anderson Fellow 2015 Head of Psychology, RCH Mental Health Royal Children’s Hospital VIC Professor Warwick Anderson Fellow 2015 Deputy Director, Centre for Values, Ethics and the Law in Medicine The University of Sydney NSW Professor Warwick Anderson AM Honorary Fellow 2015 Secretary General International Human Frontier Science Program Organization International Professor Ian Anderson AO Fellow 2018 Deputy Secretary, Department of Prime Minister & Cabinet Commonwealth Government of Australia ACT Professor James Angus AO Honorary Fellow 2015 Honorary Professorial Fellow and Emeritus
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DECR1 Is an Androgen-Repressed Survival Factor That Regulates PUFA Oxidation To
bioRxiv preprint doi: https://doi.org/10.1101/865626; this version posted December 6, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis Zeyad D. Nassar1,2*, Chui Yan Mah1,2*, Jonas Dehairs3, Ingrid J.G. Burvenich4, Swati Irani1,2, Margaret M. Centenera1,2, Raj K. Shrestha5, Max Moldovan2, Anthony S. Don6, Andrew M. Scott4, Lisa G. Horvath7, David J. Lynn2,8, Luke A. Selth1,5,8, Andrew J. Hoy9, Johannes V. Swinnen3, Lisa M. Butler1,2# 1 University of Adelaide Medical School and Freemasons Foundation Centre for Men’s Health, University of Adelaide, Adelaide, SA 5005, Australia 2 South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia 3 KU Leuven- University of Leuven, LKI- Leuven Cancer Institute, Department of Oncology, Laboratory of Lipid Metabolism and Cancer, Leuven, B-3000, Belgium 4 Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, and School of Cancer Medicine, La Trobe University, Melbourne, VIC 3084, Australia 5 Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide, Adelaide, SA 5005, Australia 6 NHMRC Clinical Trials Centre, and Centenary Institute, The University of Sydney, Camperdown, NSW 2006, Australia 7 Garvan Institute of Medical Research, Darlinghurst, NSW 2010; University of Sydney, Camperdown, NSW 2006; and University of New South Wales, Sydney, NSW 2052, Australia 8 College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia 1 bioRxiv preprint doi: https://doi.org/10.1101/865626; this version posted December 6, 2019.
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CSL Research - Investor Site Tour @ Bio21 Institute 30 April 2018
CSL Research - Investor Site Tour @ Bio21 Institute 30 April 2018 CSL Research • Bio21 / Parkville, Marburg, Bern • Protein, gene & cell based therapies Specialty Breakthrough Immunoglobulins Haemophilia Transplantation Products Medicines • ~200 staff • Molecular Biology, Protein Biochemistry, Cell Biology & Physiology, Bioinformatics, Research & Clinical Analytics, Pharm/Tox Plasma Protein Science & Discovery 2 | Driven by Our Promise™ Global Hub for Research & Translational Medicine • New laboratories being constructed on the Bio21 site, 3628m2 • CSL space from 1470m2 to 3500m2 • Capacity to increase from 75 FTE’s to 165 (relocation from PKV) • University of Melbourne to fund construction • CSL to fund fit-out of CSL space • Construction commenced Q3 2016 with fit-out completed Q3 2018 3 | Driven by Our Promise™ Melbourne / Parkville Biomedical Precinct • a CSL competitive advantage Bio21 CSL 4 | Driven by Our Promise™ Melbourne / Parkville Biomedical Precinct • a CSL competitive advantage Melb. University Royal Melb. Florey Inst. Medical School Hospital Neuroscience Doherty Inst. Immunol. Microbiol Aust. Genomics Research Facility Victorian Comprehensive Cancer Centre Peter Mac WEHI Bio21 Cancer Inst. Women’s Hospital Royal Children's Murdoch Research Hospital Institute 5 | Driven by Our Promise™ WEHI / CSL Bioinformatics Alliance WEHI - world leaders in bioinformatic software development • By research specialty - differential expression - regulation of gene expression - cancer genome analysis - statistical genetics - molecular epidemiology
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