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Table Des Illustrations ______ VETAGRO SUP CAMPUS VETERINAIRE DE LYON Année 2013 - Thèse n° 01 ACTUALITE SUR LA DEMODECIE FELINE ET PRESENTATION DE CAS CLINIQUES THESE Présentée à l’UNIVERSITE CLAUDE-BERNARD - LYON I (Médecine - Pharmacie) et soutenue publiquement le 19 Février 2013 pour obtenir le grade de Docteur Vétérinaire par TROUVE Coline Né(e) le 13 Septembre 1985 à Grenoble (38) 2 VETAGRO SUP CAMPUS VETERINAIRE DE LYON Année 2013 - Thèse n° 01 ACTUALITE SUR LA DEMODECIE FELINE ET PRESENTATION DE CAS CLINIQUES THESE Présentée à l’UNIVERSITE CLAUDE-BERNARD - LYON I (Médecine - Pharmacie) et soutenue publiquement le 19 Février 2013 pour obtenir le grade de Docteur Vétérinaire par TROUVE Coline Né(e) le 13 Septembre 1985 à Grenoble (38) 3 4 5 6 Remerciements _________________________________________ A Monsieur le Professeur Michel FAURE de la Faculté de Médecine de Lyon pour m’avoir fait l’honneur d’accepter la présidence de ce jury de thèse. Avec l’expression de mon plus profond respect et de mes plus sincères remerciements. A Monsieur le Professeur Didier PIN de VetAgroSup campus vétérinaire de Lyon pour m’avoir proposé ce sujet et m’avoir encadré tout au long de ce travail, pour son implication, sa gentillesse, sa patience et sa disponibilité. Avec toute ma gratitude et mon respect les plus sincères. A Monsieur le Professeur Gilles BOURDOISEAU de VetAgroSup campus vétérinaire de Lyon Pour avoir accepté de juger mon travail et de faire partie de ce jury de thèse. Sincères remerciements. A Monsieur le Docteur Thierry BORD Pour avoir donné son autorisation à l’utilisation d’un de ses cas cliniques. Sincères remerciements. 7 8 A ma famille 9 10 Table des matières _________________________________________ Introduction…………………………………………………………………...23 Partie 1 : Etiologie et pathogénie de la démodécie féline……………….......25 I. Définition et généralités .................................................................................................. 27 A. Définition .................................................................................................................... 27 B. Synonymie ................................................................................................................... 27 II. Présentation des parasites ............................................................................................. 29 A. Description des parasites .............................................................................................. 29 1. Généralités ................................................................................................................ 29 a) De nombreuses espèces parasitées ......................................................................... 29 b) Historique ............................................................................................................. 30 (1) Demodex cati ................................................................................................... 30 (2) Demodex gatoi ................................................................................................. 31 (3) Demodex species ............................................................................................. 31 2. Critères taxonomiques ............................................................................................... 31 3. Critères morphologiques ........................................................................................... 32 a) Demodex cati ........................................................................................................ 33 (1) L’adulte ........................................................................................................... 33 (a) Le mâle ........................................................................................................ 33 (b) La femelle .................................................................................................... 34 (2) L’œuf .............................................................................................................. 37 (3) La larve ........................................................................................................... 37 (4) Les nymphes .................................................................................................... 38 (a) La protonymphe ........................................................................................... 38 (b) Le deutonymphe .......................................................................................... 38 b) Demodex gatoi ...................................................................................................... 39 (1) L’adulte ........................................................................................................... 39 (2) L’œuf .............................................................................................................. 42 c) Demodex species ............................................................................................... 42 (1) Première description ........................................................................................ 42 (2) Une nouvelle espèce ?...................................................................................... 42 (3) Dernières actualités .......................................................................................... 43 d) Rapide comparaison des trois Demodex ................................................................ 45 4. Critères biologiques .................................................................................................. 46 a) Habitat .................................................................................................................. 46 (1) Quelques rappels anatomiques ......................................................................... 46 (a) L’épiderme .................................................................................................. 46 (b) Les follicules pileux ..................................................................................... 46 (2) Habitat de Demodex cati .................................................................................. 47 (3) Habitat de Demodex gatoi ................................................................................ 47 (4) A propos de Demodex species .......................................................................... 48 11 (5) Comparaison de l’habitat des Demodex du chat ............................................... 49 b) Nutrition ............................................................................................................... 49 c) Cycle parasitaire ................................................................................................... 50 d) Résistance dans le milieu extérieur........................................................................ 52 5. Transmission de la démodécie féline ......................................................................... 53 a) Transmission interspécifique ................................................................................. 53 b) Zoonose ................................................................................................................ 54 c) Contagion intraspécifique...................................................................................... 54 (1) Demodex cati ................................................................................................... 54 (2) Demodex gatoi ................................................................................................. 54 B. Epidémiologie .............................................................................................................. 56 1. Fréquence - Espèces affectées ................................................................................... 56 2. Répartition géographique .......................................................................................... 56 3. Facteurs intrinsèques ................................................................................................. 57 a) Race ...................................................................................................................... 57 b) Sexe ...................................................................................................................... 58 c) Age ....................................................................................................................... 58 d) Hérédité ................................................................................................................ 59 e) Etat immunitaire ................................................................................................... 59 4. Facteurs extrinsèques ................................................................................................ 60 a) L’alimentation....................................................................................................... 60 b) Traitements ultérieurs ........................................................................................... 60 c) Maladies concomitantes ........................................................................................ 60 5. Récapitulatif des données biologiques et épidémiologiques ....................................... 62 III. Pathogénie de la démodécie ......................................................................................... 63 A. Différentes actions pathogènes des Demodex ............................................................... 63 B. Pathogénie de la démodécie canine
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