Full Program

5th European Congress of Immunology 2 ECI2018 Table of Content Layout and Graphic Design p. 3 Words of Welcome p. 4 Contact Addresses p. 7 Commitees p. 8 European Congress of Immunology (ECI) p. 9 European Federaion of Immunological Socieies (EFIS) p. 10 Acteria Prizes awarded by EFIS & EFIS/EJI Ita Askonas Award p. 12 More EFIS Awards p. 13 Travel Grants p. 14 Hours of Operaion p. 18 Informaion for Speakers and Poster Presenters p. 22 CME Accreditaion p. 23 Conference Venue: Overview p. 24 Conference Venue: Room Plans p. 25 Program Overview p. 26 Scieniic Program p. 30 Business Meeings p. 33 Scieniic Satellite Meeings p. 34 Joint Symposia p. 35 Hands-on Workshops p. 38 Educaional Sessions p. 40 Men and Women in Immunology p. 41 Keynote Lectures p. 42 Scieniic Program By Day p. 46 Industry Sponsored Symposia, Sponsoring and Exhibiion p. 89 Acknowledgements p. 90 Company Descripions p. 92 Industry Sponsored Symposia p. 94 Exhibiion Informaion p. 95 Exhibiion Floor Plan p. 96 Exhibitors (A-Z) p. 97 Networking Events p. 101 The City of Amsterdam p. 102

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 3 ECI2018 Editors ECI2018 Congress President Prof. Dr. Marieke van Ham Head Dept. of Immunopathology Sanquin Research and SILS, Faculty of Science, University of Amsterdam Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands [email protected] ECI2018 Scientific Program Committee President Prof Dr. Jaques Neejes Leiden University Medical CenterDepartment of Cell & Chemical Biology P.O. Box 9600 , 2300 RC Leiden, The Netherlands [email protected] ECI2018 Local Organizing Committee President Janneke N. Samsom, PhD Erasmus University Medical Center Laboratory of Pediatric Gastroenterology P.O. Box 2040, 3000 CA Roterdam, The Netherlands [email protected] ECI2018 and EFIS President’s Office Chrisina Helbig, PhD Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands [email protected]

Layout and Graphic Design ECI2018 and EFIS President’s Office Chrisina Helbig, PhD Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands [email protected] ECI2018 Logo designed by Barbara Biegl, www.biegl-graik.at

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 4 ECI2018 Words of Welcome Welcome by the Congress President Dear Colleagues and Friends, With great pleasure we welcome you on behalf of the Dutch Society for Immunology (NVVI) and the European Federaion of Immunological Socieies (EFIS) to the 5th European Congress of Immunology (ECI) in Amsterdam from September 2-5, 2018. The 5th ECI covers all ields of modern immunology. The special focus of the 5th ECI is ‘Building Bridges’. The Dutch take pride in being expert bridge builders, physically to live among opulent environmental water, but also iguraively to connect people and facilitate mutual goals. The layout of ECI2018 has been speciically made with the ‘Building Bridges’-concept in mind: • For the Program of this 5th ECI, people from immunological socieies all over Europe and the rest of the world have intensely collaborated. We atempt to build an European village of immunology in Amsterdam. Our program ofers 150+ state-of-the ield talks by invited top of the bill immunologists and front-runners in clinical immunomodulatory therapies. Novel Educaional Sessions will bring you up to date for speciic topics. Pre- and postmeeing Scieniic Satellite Meeings give added in-depth insights into speciic ields of immunology. • Our new set-up of the ECI meeing tracks connects immunological research to clinical applicaions in speciic medical ields to bring biomedical and medical researchers together. • The Poster Sessions form the heart of the meeing. Therefore, they have been given extra ime in the program. Guided Poster Walks will allow strong exposure of all research and simulate discussions and networking. From each poster session, a candidate will be selected to move her/his poster to the Best Posters Area to contest for the poster awards. • Up-and-coming scienists, who are changing current immunological concepts through novel scieniic approaches, will be given ample room to the stage. More than 370 oral presentaions have be selected from submited abstracts for the Workshops. The best rated abstracts of young scienists have been selected for Bright Sparks Sessions. • With help of editors of high impact peer-reviewing journals, Late Breaking Hot Topics have been ideniied. These data will be presented before the Keynote lectures. • We have brought in scienists from interdisciplinary ields, like systems biology and bioinformaics. A direct interacion with them is achieved in our hands-on workshops “Deep thinking in Immunology”. Paricipants will acively model or analyze data on their own PC. They will learn how systems biology and funcional genomics integrate data into ‘deep’ (large), analyical and mathemaical models to enhance mechanisic understanding and help test hypotheses. We have much enjoyed the truly internaional efort to make an atracive program for ECI2018 and thank you for that. We much value all of your eforts to join our meeing and to take part in the internaional exchange of scieniic thoughts and ideas. While you are here, you may have a chance to discover the other faces of the Netherlands, like Amsterdam with its many canals (165), bridges (1281), enchaning canal houses, small streets and vivid markets. Over the centuries, Amsterdam has been a place of refuge for people from many diferent backgrounds. Nowadays, Amsterdam is home to people of 180 naionaliies, making it a true meling pot of naions with cosmopolitan lair. We enjoy that we can host you here and hope that you will enjoy ECI2018 in return! With best wishes, Marieke van Ham, ECI2018 Congress President

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 5 ECI2018 Welcome by the NVVI President Dear Colleagues and Friends, The Dutch Society for Immunology (NVVI) welcomes you to the 5th European Congress of Immunology, ECI2018. We are very glad to organize ECI2018 on behalf of the European Federaion of Immunological Socieies (EFIS). The Netherlands has a large immunological society, with strong historic roots. Already during the Dutch Golden Age (17th century), biomedical science was popular. Anatomy lessons, as painted by Rembrandt, were social instrucive events. Antonie van Leeuwenhoek created highly magnifying microscopes that boosted the scieniic understanding of the world of microbes and eukaryoic cells. Over the years, immunology lourished. Geert Reinders (1737-1815) was the irst to use vaccinaion against “Rinderpest”. One of the irst great European immunopathologists, Joghem van Loghem, was born in Amsterdam in 1914. The irst blood bank in coninental Europe was organized 1940 in The Hague. At Leiden University Jon van Rood pioneered in the discovery of the HLA system and put his indings into clinical pracice in solid organ and bone marrow transplantaion. To date immunological research and its clinical applicaions is sill thriving in the Netherlands. The mission of the NVVI is to acively promote and support: • Excellence in immunological research, immunodiagnosic procedures and clinical immunological pracice in the Netherlands • High quality of analyses of immunological parameters used in health care (for diagnosic purposes) • The societal posiion of the professional immunologist in all disciplines. To achieve this, the NVVI organizes scieniic and educaional meeings in the ield of immunology, maintains internaional contacts and has established a number of commitees that regulate scieniic, laboratory and clinical standards in immunology. In addiion, the NVVI strives to provide input to naional and internaional policies with the objecive to strengthen the future of immunology in all disciplines. In line with our mission, we consider it a privilege to organise ECI2018 for the internaional immunological society. We hope to share with you our vision on immunology, ranging from immunological biomedical research to clinical applicaions of immunomodulatory therapies and basic and specialised educaion in the ield of immunology. We look very much forward to the exchange of the latest indings in the ield of immunology through inspiring presentaions and open scieniic discussions at ECI2018. With our best wishes, Reina Mebius, President NVVI

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 6 ECI2018 Welcome from the EFIS President Dear Friends and Colleagues, As President of the European Federaion of Immunological Socieies (EFIS), it is my pleasure to welcome you in Amsterdam at the 5th European Congress of Immunology (ECI2018). Held every three years and regularly atracing over 3000 delegates, the ECI is now regarded as a premier venue on the internaional immunology calendar. The most recent ECI2015 in Vienna was a telling example of the success that the congress now enjoys. And ECI2018 in Amsterdam promises to coninue this tradiion by staging a truly memorable scieniic event for all atending. EFIS, together with our local host, the Dutch Society for Immunology, will work to ensure a simulaing three and one-half days during which paricipants – young and not so young, alike – will have the opportunity to interacively explore the most recent advances in the ields of innate immunity, adapive immunity, diseases of the immune system and immune intervenions. And whether you have a broad-ranging interest in the muliple facets of modern immunological research, or your focus lies in a paricular niche, you will surely come away from ECI2018 saisied by the ine balance between basic and applied/translaional research contribuions that the organizers intend to assemble. ECI2018 will also coninue the tradiion that is central to one of EFIS’ missions, namely, to foster the paricipaion and recogniion of Europe’s next generaion of immunologists at major immunology-themed meeings. And at ECI2018 early-career scienists will be given center stage on numerous occasions. To simulate the paricipaion of as many junior invesigators as possible, EFIS has provided an unprecedented number of generous travel grants. Our young colleagues should also recall that the ACTERIA Doctoral and Early Career Research Prizes awarded by EFIS will be presented for the third ime at ECI2018, and that EFIS will again acknowledge the work of two prominent European female research group leaders with the fourth EFIS-EJI Ita Askonas Prize. Inspired by one of Amsterdam’s most characterisic features, our colleagues of the Dutch Society for Immunology have aptly given ECI2018 the theme of ‚Building Bridges‘. And, indeed, it is their and our pledge to provide a seing that allows building as many bridges as possible between basic, translaional and clinical science, among younger researchers and established immunologists, and, above all, throughout the European immunology community. I am glad that you have decided to join us in Amsterdam to help make ECI2018 a resounding and rewarding success! Sincerely, René van Lier, President, EFIS

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 7 ECI2018 Contact Addresses Organized under the auspices of EFIS - European Federaion of Immunological Socieies www.eis.org NVVI – Dutch Society for Immunology www.dutchsocietyimmunology.nl Congress President Prof. Marieke van Ham PhD Department of Immunopathology Sanquin Research PO Box 9190, 1006 AD Amsterdam, The Netherlands and SILS, Faculty of Science, University of Amsterdam, The Netherlands [email protected] Congress Organization and Abstract Management Wiener Medizinische Akademie GmbH Alser Straße 4, 1090 Vienna, Austria +43 1 405 1383 39 [email protected] Exhibition and Sponsorship Management MAW – Medizinische Ausstellungs- und Werbegesellschat Freyung 6, 1010 Vienna, Austria +43 1 536 63 62 or 76 [email protected] EFIS Offices Chrisina Helbig – ECI2018 and EFIS President’s Oice Sanquin Blood Supply Foundaion Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands [email protected] Thomas Wiley – Coordinator Via Nicola Fabrizi 14, 16148 Genova, Italy [email protected] NVVI Office Dept. Laboratory of Translaional Immunology Lundlaan 6, 3584 EA Utrecht, The Netherlands +31 (0)88 75 54306 [email protected] Congress Venue RAI Amsterdam Europaplein (Entrance C), 1078 GZ Amsterdam, The Netherlands www.rai.nl

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 8 ECI2018

Committees Véronique WITKO-SARSAT, SFI Saoudi ABDELHADI, SFI subsitute* STEERING COMMITTEE Ariel AMIRAM, IIS subsitute* Marieke VAN HAM, Congress President Flavia BAZZONI, SIICA subsitute* René VAN LIER, EFIS President Mira BARDA-SAAD, IIS subsitute* Jacques NEEFJES, SPC President Janneke N. SAMSOM, LOC President FINANCIAL COMMITTEE Reina MEBIUS, NVVI Winfried PICKL, EFIS Treasurer Barbara BOHLE, ÖGAI Clemens SCHEINECKER, ÖGAI Hans YSSEL, SFI Paul GUGLIELMI, SFI Jürgen WIENANDS, DGl Carsten WATZL, DGl Angela SANTONI, SIICA Francesco ANNUNZIATO, SIICA Anna FOGDELL-HAHN, SSI Rene TOES, NVVI África GONZÁLEZ-FERNÁNDEZ, SEI Arno HANNINEN, SSI Günnur DENIZ, TSI Manel JUAN, SEI Peter OPENSHAW, BSI Arzu ARAL, TSI Blanka RIHOVA, CIS Lindsay NICHOLSON, BSI Anna ERDEI, MIT LOCAL ORGANIZING COMMITTEE Luljeta AHMETAJ, KAAIA Antonio LANZAVECCHIA, SSAI Janneke N. SAMSOM, LOC President Mira BARDA-SAAD, IIS Jacques NEEFJES, SPC President Belén DE ANDRES, SEI subsitute* Marieke VAN HAM, Congress President Marco CASSATELLA, SIICA subsitute* Gerd BOUMA, VUMC Paul GUGLIELMI, SFI subsitute* Jan DAMOISEAUX, UMCM Thomas KAMRADT, DGfI subsitute* Esther DE JONG, AMC Güher SARUHAN-DIRESKENELI, TSI subsitute* Chrisina HELBIG, SANQUIN Anna SEDIVA, CIS subsitute* Frits KONING, LUMC SCIENTIFIC PROGRAM COMMITTEE Cees VAN KOOTEN, LUMC Jon LAMAN, UMCG Jacques NEEFJES, SPC President Yang LI, UMCG Janneke N. SAMSOM, LOC President Reina MEBIUS, VUMC Marieke VAN HAM, Congress President Mihai NETEA, UMCN Silke APPEL, SSI Jaap VAN DISSEL, RIVM Edit BUZÀS, MIT Marjolein VAN EGMOND, VUMC Günnur DENIZ, TSI Hans WESTERHOFF, UVA Gary ENTRICAN, BSI Gertjan WOLBINK, READE Niels HELLINGS, BIS Nico WULFFRAAT, UMCU Michael LOHOFF, DGl Burkhard LUDEWIG, SSAI EFIS BOARD 2016-2018 Laura PAJAZITI, KAAIA René A.W. VAN LIER, President Vito PISTOIA, SIICA Andreas RADBRUCH, President-elect Angel PORGADOR, IIS Lorenzo MORETTA, Past President Ricardo PUJOL-BORRELL, SEI Pablo ENGEL, Secretary General Güher SARUHAN-DIRESKENELI, TSI Winfried PICKL, Treasurer Anna SEDIVA, CIS Rene TOES, NVVI *Atended a meeing as subsitute for the Rudolf VALENTA, ÖGAI representaive of their society. 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 9 ECI2018 European Congress of Immunology (ECI) The European Congress of Immunology - ECI - is the triennial joint meeing of all EFIS member socieies. It is one of the most renowned internaional conferences in the ield of basic and clinical immunology and atracts up to 5,000 delegates. The ECI is “the“place to build your professional network as it ofers the highest standards in terms of both scieniic and social programs. Each EFIS member society can submit a bid to host an ECI. The 5th European Congress of Immunology is held under the auspices of the Dutch Society for Immunology (NVVI). ECI2018 on social media: @eci2018 #ECI2018

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 10 ECI2018 European Federation of Immunological Societies (EFIS) About The European Federaion of Immunological Socieies (EFIS) is a non-proit umbrella organizaion that represents more than 14,000 individual immunologists from 33 immunological socieies from all across Europe, and even beyond the borders to Israel. Every acive member of any of our member socieies is automaically considered an EFIS member and can as such beneit from the EFIS programs. The main goals of EFIS are the support of immunological research and educaion as well as strengthening scieniic interacion amongst the members with: • supporing early career scienists, e.g. through fellowships or travel grants. • supporing congresses and conferences in Europe • promoing Immunology to the general public through the Day of Immunology, and other aciviies: check out the interacive exhibiion www.inside-immunity.org or the interacive book www.interacive-immunity.org

EFIS was founded at a meeing held in Amsterdam in September 1975. In the beginning, the legal body of this society was the Internaional Union of Immunological Socieies (IUIS). During a meeing held in Helsinki in 1991, it was decided to incorporate the aricles in a notarial deed, and on April 5th, 1995, EFIS was formally registered as an independent legal body c/o the Utrecht (NL) Chamber of Commerce. You can download the Statutes of EFIS and the minutes of previous EFIS General Assemblies here: htps://www.eis.org/the-federaion/statutes-and-minutes/statutes-and-minutes.html For more informaion about EFIS please visit www.eis.org

EFIS on social media: @eis_immunology

htps://www.facebook.com/European-Federaion-of-Immunological-Socieies-EFIS-620599097957021/ @eis_immunology

htps://www.linkedin.com/company/europeanfederaionoimmunologicalsocieies/

Join EFIS Newsleter: htps://www.eis.org/join-eis/index.html EFIS Offices Chrisina Helbig – ECI2018 and EFIS President’s Oice Sanquin Blood Supply Foundaion Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands [email protected] Thomas Wiley – Coordinator Via Nicola Fabrizi 14, 16148 Genova, Italy [email protected]

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 11 ECI2018

The EFIS Board The EFIS Board is composed of the President, the Vice President, the Past President, the Treasurer and the Secretary General. The Board meets about three imes a year. Board Members are elected by the EFIS General Assembly, composed of delegates of naional socieies (each society is enitled to have one delegate per 500 members), and they are appointed for a period of three years. René A.W. van Lier, President Pablo Engel, Secretary General Sanquin Blood Supply Foundaion Department of Biomedical Sciences Plesmanlaan 125 University of Barcelona Medical School 1066 CX Amsterdam, The Netherlands Casanova, 143 [email protected] 08036 Barcelona, Spain [email protected] Andreas Radbruch, President Elect Deutsches Rheuma-Forschungszentrum Winfried F. Pickl, Treasurer Berlin (DRFZ) Insitute of Immunology Charitéplatz 1 Center for Pathophysiology, Infeciology 10117 Berlin, Germany and Immunology [email protected] Medical University of Vienna Lazaretgasse 19 Lorenzo Moretta, Past President A-1090, Vienna, Austria Ospedale Pediatrico Bambino Gesù [email protected] V.le Ferdinando Baldelli, 41 00146 Rome, Italy [email protected]

Appointments with EFIS during the ECI 2018 Mark your congress program to make sure you don’t miss these important EFIS events! Monday, September 3rd • EFIS Awards Lecture Symposium, featuring the winners of the EFIS-IL Most Cited Aricle and Review Prizes and the EFIS-EJI Ita Askonas Prize, as well as the Laureates of the ACTERIA Prizes awarded by EFIS, from 10:15 - 11:30 in E104-107 • “Bright Sparks” Workshops, Monday and Tuesday, 10:15 - 11:45, Elicium and Auditorium, during which the 24 authors of abstracts selected by the ECI2018 Scieniic Program Commitee will present their work. In addiion to her/his recogniion as an ECI2018 “Bright Spark”, the 24 speakers will also receive a EUR 500.- cash prize (made possible in part by BioLegend). Wednesday, September 5th • The EFIS President’s Symposium, convened by standing EFIS Board President, Prof. René van Lier, from 10:15 to 11:45 in Elicium, enitled “T cell immunity in the front line”. ECI2018 delegates are also cordially invited to visit the EFIS Booth c/o the Society Village for a cofee and to take part in the tradiional “EFIS Passport to Prizes” rale for a chance to win numerous prizes, including travel grants to future immunology events and subscripions and textbooks from EFIS’ Oicial Journals.

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 12 ECI2018 Acteria Prizes awarded by EFIS & EFIS/EJI Ita Askonas Award On the recommendaions of the ACTERIA Prizes Selecion Jury and the Fondaion ACTERIA, EFIS is delighted to announce the laureates of the 2018 ACTERIA Prizes awarded by EFIS: Acteria Doctoral Prize in Allergology: Samuel Philip Nobs Weizmann Insitute of Science, Rehovot, Israel Nominated by the Swiss Society for Allergology and Immunology (SSAI) Acteria Doctoral Prize in Immunology: Eduardo Bonavita University of Manchester, United Kingdom Nominated by the Italian Society for Immunology, Clinical Immunology and Allergology (SIICA) Acteria Early Career Research Prize in Allergology: Muzlifah Hanifa, Newcastle University, United Kingdom Nominated by the Briish Society for Immunology (BSI) Acteria Early Career Research Prize in Immunology: Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland Nominated by the German Society for Immunology (DGfI) The ACTERIA Prizes will be formally conferred at a specially organized plenary lecture on Monday, September 3rd, 10:15 – 11:30, during which each of the four laureates will present her/his work. The ACTERIA Doctoral Prizes carry a cash award of EUR 15,000, while the ACTERIA Early Career Research Prizes amount to EUR 30,000 each. In addiion, awardees automaically qualify for 3-year research grants of up to EUR 50,000 annually.

EFIS/EJI Ita Askonas Award The Ita Askonas Award was established by EFIS and the European Journal of Immunology (EJI) in recogniion of outstanding female group leaders in immunology who have run an independent laboratory for a minimum of four and no more than eight years. This year, the award will be conferred, Monday, September 3rd, 10:15 – 11:30, ex aequo to Jenny Mjösberg, Center for Infecious Medicine, Karolinska Insitute Department of Medicine, and Katja Simon, University of Oxford Kennedy Insitute of Rheumatology. The Laureates will share the EUR 20,000 cash award plus travel support to atend ECI2018. 2018 marks the fourth ime that the Award will be conferred. Previous Laureates are: • Fiona Powrie, Kennedy Insitute of Rheumatology, Oxford, awarded at ECI2009 in Berlin • Francesca Granucci, University of Milano-Bicocca, awarded at ECI2012 in Glasgow • Karin Tarte, University of Rennes, awarded at ECI2015 in Vienna

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 13 ECI2018 More EFIS Awards EFIS-Biolegend Bright Sparks Awards With the generous support of Biolegend, EFIS is able to sponsor 24 Bright Sparks Awards during the ECI 2018. The Scieniic Commitee selected the 24 best abstracts submited by early career scienists. Those abstracts are presented in the „Bright Sparks“ workshops, Monday and Tuesday, 10:15 – 11:30 (Elicium and Auditorium). In addiion to recogniion as an ECI 2018 „Bright Spark“, they will also receive a EUR 500.- cash prize. Prizes will be awarded during the Closing and Award Ceremony, Wednesday, September 5th, 16:45 – 17:30 (Elicium). EFIS Poster Presentation Awards The EFIS proposes 24 Poster Presentaion Awards for the best posters presented during the ECI2018 in Amsterdam. The winners will receive a EUR 300.- cash prize. Poster chairpersons will evaluate all posters presented during the guided poster walks and select one poster award candidate per poster session. Award candidate posters will be earmarked at the end of each poster session by a speciic sicker (see below). Each selected poster presenter is asked to transfer the selected poster themselves to the designated BEST POSTERS AREA. Here, inal decisions on winners will be made by an award jury. Prizes will be awarded during the Closing and Award Ceremony on Wednesday, September 5th, 16:45 – 17:30 (Elicium).

ward Can er A did st Congratulations! a o te P

You have been selected. Please move your poster immediately to the BEST POSTERS AREA. Mount it on the poster board with the number assigned to your poster session. P.A1.01.18 A1.01

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 14 ECI2018 Travel Grants ECI-EFIS 2018 Travel Grants for Early Career Scientists from EFIS Affiliated National Immunological Societies The European Federaion of Immunological Socieies (EFIS) is awarding 278 travel grants at the value of up to EUR 600.- for young post-docs and PhD-students under 35 years of age requesing inancial support to atend the ECI 2018 and is pleased to announce the following EFIS travel grant awardees: Austrian Society Valenina Pucino Croatian Immunological for Allergology and Iva Filipovic Society (HID) Immunology (ÖGAI) David Busse Nina Lukač Luca Pangrazzi Lauren Whitehead Marko Šestan Marta Bermejo Jambrina Danilo Cucchi Inga Kavazović Sergio Villazala Gennaro Prota Darja Flegar Liisa Andersen Jacqueline Siu Czech Immunological Julia Brunner Sophie Ward Laura Gail Thomas Tull Society (CIS) Manuel Reithofer Norzawani Buang Klara Ruppova Suraj Varkhande Dhiren Patel Lenka Súkeníková Bernhard Kratzer Silvia Cellone Trevelin Alena Moudra Andreas Meryk Giovanni Povoleri Viktor Černý Teresa Preglej Harriet Purvis Zuzana Stehlikova Carina Miggitsch Teja Rus Stepan Coufal Peter Tauber Shahd Talhouni Alena Fajstova Ioanna Aggeletopoulou Natalie Galanova Belgian Immunological Judith Secklehner Society (BIS) Mark Hayes Dutch Society for Ioannis Skordos Georgina Bowyer Immunology (NVVI) Hind Hussein Eleni Konstaninopoulou Carolien van de Sandt Yousra Ajouaou Charlote de Winde Maria Joosse Maya Imbrechts Sky Ng Hendy Kristyanto Cindy Hoeks Greg Crawford Sandrine Nugteren Bert Malengier-Devlies Kathryn Steel Panagiota Boui Jorrit De Waele Blagoje Soskic Paulo Marins Urbano Charlote Bertrand Rachel van de Merwe Liza Rijvers George Elias Monica Sen Felix Behr Paulien Baeten Faith Uwadiae Suraya Elfrink Kevin Englebert Adefunke Ogunkanbi Loreto Parga Vidal Jamie van Langelaar Bieke Broux Bulgarian Society for Christopher Stairiker British Society for Immunology (BuSI) Myrthe van Delt Immunology (BSI) Nikola Ralchev Lea Costes Munir Akkaya Silviya Bradyanova Ramin Raoof Louise Hosie Petya Ganova Melissa van Gool Emma Chambers Gabriela Boneva Dieke van Dinther Dominika Gajdasik Iliyan Manoylov Marlieke Jongsma

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 15 ECI2018

Pauline van Schouwenburg Lorenz Kretschmer Aoife McElroy Cynthia Fehres Toszka Bohn Dylan Ryan Yannick van Sleen Anika Koenig Mariana Cervantes-Silva Antonius de Waard Nathalie Diener Marah Runtsch Estonian Society for Chrisian Neumann Italian Society for Julia Reichwald Immunology (EIAS) Immunology, Clinical Anna Kordowski Immunology and Astrid Oras Lucas Oto Allergology (SIICA) Epp Kaleviste Siska Wilantri French Society for Sophia Michelchen Andrea Ponzeta Valenino Le Noci Immunology (SFI) Alina Huth Chrisian Orlik Vanessa Zurli Jean-Louis Palgen Nikolaos Papaioannou Federica Laudisi Yenkel Grinberg-Bleyer Mateo Stravalaci Cécile Apert Max Luedemann Teresa Wiese Ilenia Pacella Moitza Principe Katharina Bomans LauraMarongiu Silvia Menegai Irene Maiola Agathe Malbec Hellenic Society of Sara de Biasi Candie Joly Immunology (HSI) Marina Molgora Raphaël Maiuz Ioannis Panagoulias Valeria Mollica Poeta Pukar KC Ioanna Zerva Olivia Marini Eienne Haton Chiara Mazzoi Anne-Perrine Foray Hungarian Society for Claudia La Rocca Immunology (MIT) Georgian Association of Sara Bruzzanii Allergology and Clinical Katalin Böröcz Alessio Mazzoni Marcell Cserhalmi Immunology (GAACI) Eszter Boldizsár Lithuanian Society for Nino Nanava Szilvia Lukácsi Immunology (LSI) Ketevan Mazmishvili Nikolet Lupsa Agata Mlynska Nino Toria Balázs Barátki Polish Society for German Society for Bence Szikora Fundamental and Clinical Bernadet Mácsik-Valent Immunology (DGfI) Immunology (PTDiK) Réka Kugyelka Yassin Elfaki Katarzyna Nazimek Jana Sonner Immunological Society of Dorota Iwaszkiewicz-Grzes Johanna Kabbert Serbia (ISoS) Mateusz Gliwiński Katja Otmüller Nevena Gajovic Sandra Gromolak Antonie Friedl Milena Jurisevic Sebasian Wawrocki Ritu Mann-Nütel Neda Djedovic Lilit Hovhannisyan Haeberle Stefanie Dragica Gajić Katarzyna Węgierek Regina Stark Ivan Koprivica Agnieszka Szczygieł Chrisina Lückel Dragana Djordjevic Portuguese Society for Miriam Bosch Sergej Tomic Hassan Elsayed Immunology (SPI) Cansu Yerinde Irish Society for Nuno Domingues Ioannis Kienes Immunology (ISI) Filipa Ribeiro Sophie Henneberg Mark Hughes Joana Gaifem Nicole Hannemann James Early Jose Almeida-Santos 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 16 ECI2018

Carlos Magalhães Joana Vitallé Billur Akkaya Rita Silva-Gomes Olatz Zenarruzabeiia Merve Cebi Carolina Ferreira Belaustegi Izel Yilmaz Inês Mesquita Esther Bernaldo de Quirós Mehmet Hocaoglu Rafael Blanco-Dominguez Basak Aru Romanian Society for Sara Roman-Garcia Alper Kursunel Immunology (SIR) Saniago Sánchez Alonso Ece Tavukcuoglu Sonya Ioana Ciulean Daniel Garcia-Cuesta Gurcan Gunaydin Russian Society for Iñaki Etxeberria Ayhan Parlar Immunology (RSI) Joan Puñet-Oriz Aydan Sarac Elena Blinova Raquel García Ferreras Cevriye Pamukcu Raquel Benítez Goksu Kaya Valenina Mikhailova Ana Marín-Leal Ozlem Bulut Ekaterina Pashkina Alba Murcia Ceballos Igor Obraztsov Didem Ozkazanc Unsal Mariona Cabo Naz Sürücü Mikhail Pogorelyy Gizem Kilic Anastasia Minervina Paula Saz-Leal Amalia Tejeda Velarde Basak Kayaoglu Alina Alshevskaya Itziar Otano Naz Bozbeyoglu Sofya Erokhina Irem Evcili Alisa Muratova Carmen Oeo-Santos Crisina Català Ilhan Tahrali Irina Nikiina Paola Brandi Gurcan Tunali Ekaterina Komech Sandra Medrano-Garcia Muzafer Yildirim Scandinavian Society for Fehim Esen Swiss Society for Immunology (SSI) Allergology and Ukrainian Society of Rubin Joshi Immunology (SSGAI) Specialists in Clinical Sakari Pöysi Michelle Schorer Immunology and Allergy Satu Silojärvi Pascal Näf (UTIAI) Keying Zhu David Pejoski Oleksandr Korotkyi Jinming Han Suzanne Welten Taras Zadvornyi Priscilla Kerkman Marie Ballester Yevheniia Hurmach Xiaomeng Hu Giulia Vanoni Vasyl Hurmach Andri Lemarquis Olha Shtepa Spanish Society for Turkish Society of Immunology (TSI) Immunology (SEI) Grants will be paid by bank transfer ater ECI 2018 has taken place. In order to claim their award, grant holders will be required to conirm their atendance during the congress c/o the EFIS booth in the Society Village. ECI-AAI Travel Grants for Trainees from Developing Countries The European Congress of Immunology is pleased to announce the following travel grant awardees sponsored by the American Associaion of Immunology (AAI) with EUR 600.- as a contribuion towards travel expenses: Ahmed Hamada, Egypt Neema Negi, India Muhammad Bashir, Pakistan Somaditya Dey, India Ravi Sharma, India Sumanta Naik, India Daniel Antwi-Berko, Ghana Vijay Kumar, India Andranik Durgaryan, 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 17 ECI2018

Armenia Sakshi Malik, India Saswai Das, India Saidrakhim Lukmonov, Lata Singh, India Shalini Kashipathi Uzbekistan Mithalesh Singh, India Sureshbabu, India Charu Aggarwal, India Saurabh Bhargava, India Puja Sohal, India Khadija Bahrini, Tunisia Surbhi Khurana, India Sarmistha Saha, India Hriika Sharma, India Fatma Dhafouli, Tunisia Wesley Brandão, Brazil Gurupreet Sethi, India Adeyinka Odebode, Nigeria Insaf Merime Boutemine, Olfa Maghrebi, Tunisia Roksana Zakharyan, Morocco Sheriene Aify, Egypt Armenia Grants will be paid in cash onsite at the General Informaion Desk. IUIS Travel Grants for Early Career Scientists from IUIS Affiliated National Immunological Societies The European Congress of Immunology is pleased to announce the following travel grant awardees sponsored by the Internaional Union of Immunological Socieies (IUIS) with EUR 600.- as a contribuion towards travel expenses: Reza Yazdani, Iran Qi Chen, Singapore Sarra Hamrouni, Tunisia Suyasha Roy, India Farimah Masoumi, Iran Min Jung Kim, Republic of Paula Niewold, Australia José Rojas Morales, Chile Korea Sebasian Miles, Uruguay Lilian Oliveira, Brazil Grants will be paid in cash onsite at the General Informaion Desk. NVVI Travel Grants for Early Career Scientist from Developing Countries The European Congress of Immunology is pleased to announce the following travel grant awardees sponsored by the Dutch Society for Immunology (NVVI) with EUR 600.- as a contribuion towards travel expenses:

Amit Awasthi, India Mariia Rudyk, Ukraine Ethiopia Doaa Glal, Egypt Pragai Sharma, India Iryna Garmish, Ukraine Vivek Dharwal, India Rym Ouni, Tunisia Mulki Angela, Indonesia Filimon Miiku Haile, Grants will be paid in cash onsite at the General Informaion Desk.

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Hours of Operation Exhibition Service Desk General Information Desk Saturday/Sunday 8:00 - 22:00 Monday/Tuesday 8:00 - 19:30 Sunday 9:00 - 19:00 Wednesday 8:00 - 22:00 Monday 7:30 - 19:00 Tuesday 8:00 - 19:00 Exhibition Wednesday 8:00 - 16:30 Saturday/Sunday build up Registration Desk Monday/Tuesday 9:30 - 19:30 Wednesday 9:00 - 12:30 Sunday 9:00 - 19:00 Monday 7:30 - 19:00 Speaker Service Center Tuesday 8:00 - 19:00 Sunday 12:00 - 18:00 Wednesday 8:00 - 16:30 Monday 7:30 - 19:00 Cloakroom Tuesday 7:30 - 18:15 Wednesday 8:00 - 17:30 Sunday 8:00 - 21:00 Monday/Tuesday 8:30 - 20:00 Poster Printing Desk Wednesday 8:30 - 18:00 Sunday 8:00 - 18:30 Food Outlets Monday/Tuesday 8:00 - 19:30 Wednesday 8:00 - 11:45 Monday/Tuesday 9:30 - 19:30 Wednesday 9:00 - 12:30 Poster Mounting RAI Service Desk Monday-Wednesday 9:30 - 10:00 Sunday 8:00 - 22:00 Poster Removal Monday/Tuesday 7:30 - 20:00 Monday/Tuesday 19:30 - 20:00 Wednesday 7:30 - 18:00 Wednesday 11:45 - 12:30 Congress Information A-Z App information The ECI smartphone app can help you to get the best out of the ECI! The app allows you to: • browse, search and personalize the enire event program • access useful informaion about the congress • access all abstracts The app allows users to access informaion oline to avoid roaming costs. It can be downloaded from your app store and works with iOS and Android. Search your app store for ECI2018. ECI thanks Abbvie for their sponsorship of the Congress App. Badges Each paricipant receives a name badge upon check-in at Registraion. As only registered paricipants will be permited to atend the scieniic sessions, the exhibiion and poster areas, you are required to wear your badge when entering and while remaining in the congress venue. If you have lost your badge, a new one can be purchased (with proof of

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 19 ECI2018

your original registraion) on-site at the Registraion Desk for EUR 50.00. Please have your badge scanned daily at the Congress Informaion Desk in order to claim the full amount of CME credits. Bank Services - Money Matters Banks are usually open from 09:00-16:00 (Monday-Friday), with a few big city banks also open Thursday evening unil 21:00 or on Saturday morning. Oices are usually open from 09:00-18:00 (Monday-Friday) and closed during the weekends. There will be ATMs all over the city of Amsterdam. At the airport and main staion and along the main streets you ind currency exchange oices as well. An ATM is available in the entrance area of the RAI Amsterdam. Certificate of Attendance and CME Credits Ceriicates of atendance, payment and CME ceriicate will be sent per email to all paricipants ater the congress. For more details, please ask at the General Informaion Desk in the main Entrance Hall. Climate The average temperatures in September in Amsterdam are 19°C (high) and 11°C (low). Cloakroom A cloakroom (with luggage storage) is located in the entrance hall. It is free of charge for congress atendees. For opening hours see p. 18. Continuing Medical Education (CME) Credits ECI 2018 has been accredited by the European Accreditaion Council for Coninuing Medical Educaion (EACCME), an insituion of the European Union of Medical Specialists (UEMS) to provide the following CME acivity for medical specialists. The Congress is designated for up to 23 hours of European external CME credits (ECMECs). Please see p. 23 for more informaion on how to claim your CME credits. Currency The Netherlands is a member of the Economic and Currency Union and the common currency is the Euro. EFIS Booth ECI2018 delegates are cordially invited to visit the EFIS Booth c/o the Society Village for a cofee and to take part in the tradiional “EFIS Passport to Prizes” rale for a chance to win numerous prizes, including travel grants to future immunology events and subscripions and textbooks from EFIS’ Oicial Journals. Emergencies Please contact a member of congress staf immediately in the case of a real or suspected emergency situaion. The European emergency number applies in The Netherlands, and callers should dial: 112. Insurance/Liabilities and Disclaimer ECI will not be held liable for personal injuries or for loss of or damage to property 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 20 ECI2018

incurred by paricipants at the ECI 2018. Paricipants are encouraged to purchase insurance to cover loss incurred in the event of cancellaion, medical expenses, or damage to or loss of personal efects when travelling outside of their own countries. ECI cannot be held liable for any hindrance or disrupion of the ECI Congress 2018 proceedings arising from natural, poliical, social or economic events or other unforeseen incidents beyond its control. Registraion of a paricipant implies acceptance of this condiion. Flight Check-in Flight check-in terminals will be available to delegates in the registraion area, for online light check-in. A printer will be available to print boarding passes. This service will be open on Tuesday and Wednesday . Food and Beverages The main catering services (cofee and lunch bag staions) are located in the Exhibiion Halls. In addiion, 4 diferent cash bars will ofer a variety of food opions, from burgers to sushi. Cofee and tea during oicial cofee breaks is included in the registraion fee. Lunch bags are not included in the registraion fee and had to be pre-ordered. For logisical reasons lunch bags cannot be ordered onsite. Muliple cash bars with a variety of food opions will be available. These cash bars will be open at all imes during the exhibiion opening hours, see also p. 18. Internet Access For WiFi access, choose the ECI2018RAI network. The password is amsterdam. Job Announcements Job announcements can be displayed on a designated info wall in the Exhibiion Hall. Language The oicial language of the congress is English. No simultaneous translaion is provided. Lost and Found Please contact the General Informaion Desk in the registraion area for personal belongings that have been lost or found. Mobile Phone Policy Please respect the congress policy and keep mobile phones on silent in all meeing rooms, the Exhibiion Hall and Poster Area. Online Program Planner An online program planner to create your individual iinerary including the full informaion on all sessions, speakers, chairs and abstracts is available on the congress website: www.eci2018.org. The online planner has a search funcion with which you can ind speakers, topics, session types and much more. You can also build your personal congress iinerary by selecing presentaions and sessions from the program, using the search tool. The iinerary can be printed and exported as csv/excel ile. It can also be

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exported to your calendar in various systems (such as MS Outlook and Apple iCalendar). It is also possible to ind single abstracts. Alternaively, why not download the Congress app for full informaion on the Scieniic Program and more. Parking The RAI Amsterdam provides covered, secure parking. 1 hour EUR 4, maximally EUR 24 per day. For online day ickets at EUR 20/day visit htps://parkeren.rai.nl/en/booking/period.html Central Medical Services Centrale Doktersdienst, open 24h, will inform you about the general praciioner in your area as well as doctors who will help you during the weekend. Phone: 0900 503 20 42 Pharmacies A central service (Centraal Apotheken Dienst) informs you about the pharmacies on duty, their number is (Dutch speaking service): 020 592 33 15 Poster Exhibition Scieniic posters are displayed in the poster areas in the Exhibiion Hall. Posters will be displayed for a full day either on Monday, Tuesday or Wednesday. Each day, the posters are organised in themaic groups of approx. 20 posters. During the poster sessions the presenters are required to stand by their posters to deliver a concise poster presentaion of not more than 3 minutes and to answer quesions from delegates. During this ime, two chairpersons per group will also visit each poster and ask the presenters to briely present their indings. Visit the Poster Help Desk for any quesions you might have regarding the poster presentaions. Poster Removal The organisers cannot assume any liability for loss or damage of posters displayed in the poster areas. Posters need to be removed on the day of presentaion between 19:30 – 20:00 strict (11:45 – 12:30 on Wednesday). Access ater 20:00 (12:30 on Wednesday) is not possible! Posters not removed unil 20:00 on the day of presentaion (12:30 on Wednesday), will be taken down by the staf of the conference center and will not be stored or sent to the authors ater the meeing. Photographing and Recording Taking photographs or making any other form of electronic recording (also with mobile phones) during the sessions in the meeing rooms is forbidden. Safety and Welfare Amsterdam can be considered just as safe as other comparable ciies in Europe. However, we recommend to keep in mind the following basic precauionary measures: • Do not carry important items (e.g. light ickets, passports) with you when visiing the congress or strolling through the city, but leave them in the hotel safe. • Try not to carry all essenial and valuable items such as documents, money and credit

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cards in one bag. • In heavily frequented tourist zones, be aware of atemps of scam and pickpockeing.

ECI / EFIS holds a very irm posiion against any form of discriminaion or untoward behaviour by congress paricipants. If any paricipant feels that they have been subjected to any inappropriate behaviour, please report it immediately to a senior member of congress staf at the General Informaion Desk in the Registraion Area and the mater will be referred to the local authoriies for further invesigaion. Session Attendance Sessions may ill up quickly. Please arrive in good ime for the start of the session. Due to security regulaions, hosts and hostesses are instructed to restrict access once the maximum capacity of the room is reached. Social Media #ECI2018 @ECI2018 @eis_immunology www.facebook.com/European-Federaion-of-Immunological-Socieies- EFIS-620599097957021/ Society Village The society village is located in the exhibiion hall. Naional EFIS ailiated socieies as well as internaional associaions will provide a plaform for internaional exchange and inform about the newest developments in their own countries. Speaker Service Center The Speaker Service Center is located on level 1 in the Holland Lounge. For opening hours see p. 18. Staff The congress staf (recognizable by badge and t-shirt) will be pleased to help you with quesions. Telephone Calls The country code of The Netherlands is 31. To call abroad, dial 00 before the country code. Information for Speakers and Poster Presenters Due to EACCME regulaions, authors are requested to disclose possible conlicts of interest on the irst slide or on the poster. When presening data and health informaion (including photos) all presenters must have informed consent compliant with human subjects and applicable regulaions. Oral Presentations Speakers lecturing at the conference will be required to sign into the Speaker Service Centre (SSC) no later than 2 hours before the start of their lecture. The SSC is equipped

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with terminals where speakers can upload their presentaion into the presentaion management system. The system will ensure that proper presentaions are available in the right lecture room, at the right ime. The SSC will be labelled on the loorplans as SSC. Signage at the venue is pleniful and hostesses for direcions are available on site. Upon entering the stage for the lecture, you will ind your name on the touch screen control unit. When you tab your name, your presentaion will start, just as you praciced in the SSC. Poster Presentations Posters will change every day. Poster mouning on the respecive days will be possible between 09:30 – 10:00 strict. Posters need to be removed on the day of presentaion unil 20:00 strict (12:30 on Wednesday). CME Accreditation The 5th European Congress of Immunology, Amsterdam, The Netherlands, September 2-5, 2018 has been accredited by the European Accreditaion Council for Coninuing Medical Educaion (EACCME®) with 23 European CME credits (ECMEC®s). Each medical specialist should claim only those hours of credit that he/she actually spent in the educaional acivity. Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Associaion, physicians may convert EACCME® credits to an equivalent number of AMA PRA Category 1 CreditsTM. Informaion on the process to convert EACCME® credit to AMA credit can be found at www.ama-assn.org/educaion/ earn-credit-paricipaion-internaional-aciviies. Live educaional aciviies, occurring outside of Canada, recognised by the UEMS- EACCME® for ECMEC®s are deemed to be Accredited Group Learning Aciviies (Secion 1) as deined by the Maintenance of Ceriicaion Program of the Royal College of Physicians and Surgeons of Canada. CME Acquisition Procedure The ECI 2018 is happy to introduce a digital CME acquisiion system. Evaluaion and CME acquisiion will be possible online ater the congress. A corresponding email will be sent to all paricipants. Each ECI delegate will be able to view and print a conirmaion staing the according number of CME credits. It is possible to claim a maximum of 23 European CME credits (ECMEC®s) for atendance of scieniic sessions at the ECI 2018. IMPORTANT: Please make sure to have your badge scanned daily at the General Informaion Desk in order to gain the maximum amount of CME credits. The printout of your record should be submited to your naional jurisdicion (usually responsible for accreditaion) for approval of your CME points. Please note that the record of atendance will be issued only to the paricipant. It will not be supplied to any accreditaion agency or other organisaion. Please note that the ECI 2018 does not provide printed CME ceriicaions onsite.

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 24 ECI2018 Conference Venue: Overview ast

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A e rst Floor rst Fi rdam r fé fé pe ont Squar te Ca ye ro Fr Ams r / Fo and Ca Eu Gr orium dit RAI Theate Au m RAI Eliciu Harbour RAI Entrance C

r rk ye Pa Fo m oru F Holland Restaurant B

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5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 25 ECI2018 Conference Venue: Room Plans 1st Floor

Emerald Room Auditorium / RAI Theater

Emerald Upper Lounge Lounge G101 Topaz Lounge G102 Forum Ruby G103 E102 Lounge E101 G104

G105

E103 G106

G107 E104 G108 E105 Congress Square G109 E106

G110 E107 G111

E108 Amsterdam Suite

Europe Lounge

First Floor First Floor Lounge Restaurant Elicium 1 Elicium 2

Holland Lounge

2nd Floor

D201 D202 D203 D204 C206 Elicium Mezzanine

C205

C201 Elicium

C202

C204 C203 ELICIUM SECOND FLOOR

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 26 ECI2018 Program Overview nds-on Workshops! nds-on Please see p. 94 for Industry Sponsored Symposia and p. 38 for Ha for 38 p. and Symposia Sponsored Industry for 94 p. see Please

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Scientiic Program ECI2018 Content Tracks The scieniic program of the ECI 2018 will be structured into ive main tracks: Track A Immune development and difereniaion Track B Tumor immunology and therapy Track C Autoimmunity, allergy and transplantaion Track D Infecions and microbial immune regulaion Track E Immunomics – Technical advances and big data How to read the presentation numbers WS.B1.06.04: WS stands for one of the following session types KL: Keynote Lecture EP: EFIS President Symposium S: Symposium BS: Bright Spark JS: Joint Symposium WS: Workshop EDU: Educaional Session HT: Late Breaking Hot Topic MWI: Men and Women in Immunology P: Poster Session WS.B1.06.04: B stands for one of the following tracks: A: Immune development and difereniaion B: Tumor immunology and therapy C: Autoimmunity, Allergy and Transplantaion D: Infecions and microbial immune regulaion E: Immunomics - Technical advances and big data WS.B1.06.04: 1 indicates the subtopic within the respecive track WS.B1.06.04: 06 indicates the chronological order of sessions within the respecive subtopic WS.B1.06.04: 04 indicates the chronological order of presentaions within the respecive session Thus, WS.B1.06.04 indicates the fourth talk in workshop 06 of subtopic B1! Session Type Description - Invited Program Keynote Lectures (KL.01 - KL.08) The keynote lectures are the most presigious sessions of the congress. These are exhausive reviews of major subjects and state of the art techniques within the ield, addressed to all paricipants. Speakers in keynote lectures are invited and are among the most renowned in their ield of experise. Keynote lectures are scheduled at „prime ime“ in the program in order to achieve maximal atendance. EFIS President`s Symposium (EP.01) The EFIS President`s Symposium is a newly introduced format which will draw the atenion to the research area of the current EFIS president. Symposia (S.A1-A6 / S.B1-B4 / S.C1-C6 / S.D1-D4 / S.E1-E4) The symposia are state-of the art educaional sessions in which invited speakers share new results with other researchers on a given topic. The aim is to relect and compare

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data with other perhaps contradictory results and to discuss new hypotheses and concepts for further research with well-established colleagues. In every concurrent symposium three 20+5-minute lectures will be presented that provide an update and understanding of new developments and innovaions in a certain area. Men and Women in Immunology (MWI.01) Gender imbalance in science (and society) is a long-standing issue that has moved into the spotlight in the European Union in recent years. This symposium highlights the historical perspecive of exclusion of women in science and discusses the current situaion of women in immunology. The symposium is supposed to increase visibility of women and their achievements in science and especially within the ield of immunology. A round table with all speakers and chairpersons will discuss the most important points raised during the presentaions, the most urgent goals and the most achievable goals as well as the means to achieve these goals. Program on p. 41. Joint Symposia (JS.01-10) Joint Symposia are sessions in which the ECI joins forces with important internaional scieniic socieies to facilitate knowledge transfer and bring researchersfrom related disciplines and/or diferent coninents together in order to foster exchange and networking across all borders. This is your chance to expand your knowledge beyond the tradiional limits. Joint Symposia consist of 3 speakers (30 minutes per talk) on a topic nominated by the partner society. Detailed program on p. 35. Educaional Sessions (EDU.01-03) All registered congress delegates can paricipant in all Educaional Sessions for free. No seperate registraion is required. For details visit p. 40. Hands-on Workshops (HW.01-06) The main goal of the session is to create theoreical and paricularly pracical competences in an integrated manner and to involve pracical experience of new technologies to be used for the own research. For details go to p. 38. Session Type Description - Submitted Program Late Breaking Hot Topics (HT.01-08) The late breaking hot topics are scheduled prior to keynote lectures and ofer the possibility to present the most recent and exciing discoveries. Most Late Breaking Hot Topics have been ideniied with the help of editors of high impact peer-reviewed scieniic journals. Bright Sparks Workshops (BS.A.01 / BS.B.01 / BS.C.01 / BS.D.01) The most notable and exciing work from abstracts submited to the conference by early career scienists will be honored with an oral presentaion in one of the Bright Sparks Workshops. Presenters are expected to explain their work and answer quesions from the audience. The awardees for the Biolegend Bright Sparks Awards will be chosen from those presentaions. Workshops (WS.A1-A6 / WS.B1-B4 / WS.C1-C6 / WS.D1-D4 / WS.E1-E4) The most notable and exciing work from all abstracts submited to the congress will be honored with an oral presentaion in these sessions. Presenters are expected to explain their work and answer quesions from the audience. 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 32 ECI2018

Guided Poster Sessions (P.A1-A6 / P.B1-B4 / P.C1-C6 / P.D1-D4 / P.E1-E4) Poster presentaions are the scieniic heart of the meeing. The majority of congress atendees present a poster showing data and progress with their personal research. Posters ofer an excellent opportunity for people interested in a paricular topic to meet and exchange ideas and network with other researchers. Posters should NOT be used to adverise a product or service. Like a paper, a poster abstract should detail the focus of the presentaion and the way(s) in which it contributes to the body of knowledge in its ield. Guided Poster Walks will be chaired by ECI faculty members and senior researchers within the respecive areas. Presenters are requested to be at their posters at these imes and are asked to prepare a short pitch of maximally 2 minutes to present the key data of their posters to the chairs and paricipants. We hope to have lively discussions and a good exchange of scieniic indings and ideas in our poster sessions. Posters will generally be on display during the whole conference for free poster viewing. The chairpersons of the guided poster walks will also evaluate all posters of their session and will select the candidates for the ECI2018 Poster Awards. The selected poster award candidate will be earmarked by a sicker. The presenter is asked to move this poster to the designated BEST POSTERS AREA immediately ater the poster session. Here a designated award jury will then select the inal awardees to receive the ECI 2018 Poster Awards.

Track A Track B Track C Track D Track E Monday P.A1.01 P.B1.01-P.B1.03 P.C1.01-P.C1.03 P.D1.01-P.D1.02 P.E1.01 P.A2.01 P.B2.01-P.B2.02 P.C2.01-P.C2.03 P.D3.01-P.D3.02 P.E2.01 P.A3.01-P.A3.02 P.B3.01-P.B3.02 P.C3.01 P.D4.01-P.D4.03 P.A4.01 P.B4.01 P.C4.01 P.A5.01-P.A5.02 P.C5.01, P.C5.04 P.A6.01 P.C6.01-P.C6.02

Tuesday P.A1.02 P.B1.04-P.B1.05, P.C1.04-P.C1.05 P.D1.03 P.E1.02 P.A2.02 P.B1.09 P.C2.04-P.C2.07 P.D2.01 P.E3E4.01 P.A3.03-P.A3.05 P.B2.03, P.B2.05 P.C3.02 P.D3.03 P.A4.02 P.B3.03 P.C4.02 P.D4.04-P.D4.06 P.A5.03-P.A5.04 P.B4.02 P.C5.02 P.A6.02 P.C6.03-P.C6.04

Wednesday P.A2.03-P.A2.04 P.B1.06-P.B1.08 P.C1.06-P.C1.08 P.D1.04 P.E4.01 P.A3.06-P.A3.07 P.B2.06-P.B2.07 P.C2.08-P.C2.11 P.D2.02 P.A4.03 P.B3.04 P.C3.03-P.C3.04 P.D3.04 P.A5.05-P.A5.07 P.B4.03 P.C4.03 P.D4.07-P.D4.11 P.C5.03 P.C6.05-P.C6.06

Sponsored Program Industry Sponsored Symposia (IS.01-05) Sponsors are approved as reputable and relevant by the Scieniic Program Commitee, but the detailed content of the presentaions is proposed directly by the sponsors and under their responsibility. The organizers are not endorsing the content in any way. Detailed informaion on p. 94.

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 33 ECI2018 Business Meetings Sunday, September 2nd 11:00 - 13:00 BA.01 HCDM Council Meeing G108 closed 11:00 - 14:00 BA.02 DGfI Board Meeing D201 closed Monday, September 3rd 12:45 - 13:45 BA.03 NVVI General Assembly G109 only members 13:15 - 14:30 BA.04 SSI Council Meeing D201 closed 13:15 - 14:45 BA.05 COST Acion AFACTT G110 closed 14:45 - 16:00 BA.06 ACTERIA Alumni Session G109 open 15:30 - 17:00 BA.07 IUIS-EFIS Annual Collaboraion Review Meeing G108 closed 17:30 - 18:30 BA.08 ÖGAI General Assembly G110 only members 17:30 - 19:30 BA.09 Scandinavian Journal of Immunology - D201 closed Editorial Board Meeing 18:00 - 19:30 BA.10 DGfI General Assembly D202 only members 18:30 - 19:30 BA.25 European Journal of Immunology Alumni G109 closed meeing (Wiley) Tuesday, September 4th 08:30 - 12:30 BA.26 Consorium meeing Target to B! G109 closed 12:00 - 14:00 BA.11 DGfI Public Relaions Commission G101 closed 12:00 - 14:00 BA.12 EEIG ECI-EFIS General Meeing D201 closed 12:45 - 15:00 BA.13 SIICA Board Meeing G108 closed 13:00 - 14:00 BA.14 BIS General Assembly G110 only members 13:15 - 14:30 BA.15 SSI General Assembly D202 only members 14:00 - 17:00 BA.16 EFIS General Assembly G109 only members 15:00 - 16:00 BA.27 BSI/DGfI Iniiaives D201 closed 17:00 - 18:00 BA.17 EFIS Board Meeing G108 closed 17:00 - 19:00 BA.18 SIICA General Assembly D202 only members 17:30 - 19:30 BA.19 DGfI Forum ‚Former Presidents and G101 closed Secretary Generals‘ 17:45 - 18:30 BA.20 SEI Board Meeing G110 closed 18:30 - 19:30 BA.21 SEI General Assembly G110 only members 18:00 - 19:30 BA.22 DGfI Comitee Gender Equality and D201 closed Career Support 18:00 - 19:30 BA.23 ENII-Alumni reunion G109 open Wednesday, September 5th 10:15 - 11:15 BA.24 SFI General Assembly D202 only members

Disclaimer Ancillary and satellite meeings shall not state or imply endorsement of, or support by the ECI2018 of the event, organizer, products or services presented in any verbal statements or printed/electronic media before, ater and during the presentaions.

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 34 ECI2018

Scientiic Satellite Meetings Pre-Congress Satellites Sunday, September 2nd, 2018 10:00 - 14:30 Advanced Cytometry Course E102 10:00 - 14:30 Bidirecional communicaion between the brain and the G109 immune system 10:00 - 14:30 ENLIGHT-TENed by big data: advancing T cell Immunology G106-107 10:00 - 14:30 Common disease mechanisms of chronic inlammaion: new challenges for precision medicine D202 10:00 - 14:30 Advancements in Tolerance-inducing cellular therapies - G102-103 an update by AFACTT (EU COST acion to focus and accelerate tolerance-inducing cellular therapies) Post-Congress Satellite September 5-7, 2018 European Veterinary Immunology Workshop (Pre-registraion required) Het Spoorwegmuseum, Maliebaanstaion 16, 3581 XW Utrecht

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 35 ECI2018 Joint Symposia JS.01 - Trends in Vaccinology Joint Symposium with the Internaional Union of Immunological Socieies (IUIS) Monday, September 3rd, 2018; 13:15-14:30; Elicium Chairpersons: Alberto Mantovani, Italy & Ursula Wiedermann, Austria Systems Vaccinology: New chances for vaccines against communicable and non-communicable diseases Bali Pulendran, United States of America Novel vaccines against old foes: Dengue, Zika, Ebola & Co Franz X. Heinz, Austria New generaion of adjuvants: each target group its own adjuvant? Ed Lavelle, Ireland Prize for Excellence in Vaccines Research and Development in Europe: announcement of the winner 2018 and ceremony (sponsored by Vaccines Europe).

JS.02 - Systems Immunology for stratifying patients with autoimmune diseases Joint Symposium with the European League Against Rheumaism (EULAR) Monday, September 3rd, 2018; 13:15-14:30; Auditorium Chairpersons: Riita Lahesmaa, Finland & Timothy R.D. Radstake, The Netherlands Molecular reclassiicaion of Immune mediated inlammatory condiions as the road to personalised medicine Timothy R.D. Radstake, The Netherlands Forgoten anibodies of the gut mucosa: IgM and IgA2 Andrea Cerui, Spain The Straiicaion of Lupus Martha Alarcon-Riquelme, Spain

JS.03 - Antigen Presentation in Health and Disease Joint Symposium with the American Associaion of Immunologists (AAI) Monday, September 3rd, 2018; 13:15-14:30; Forum Chairpersons: Nilabh Shastri, United States of America & Anne Spurkland, Norway Lymph: composiion, circulaion and immunological role Laura Santambrogio, United States of America Anigen processing and presentaion in cancer immunosurveillance Robert Binder, United States of America Generaing pepide-MHC ligands for immune surveillance of foreign and self Nilabh Shastri, United States of America

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JS.04 - HLA in Transplantation and Autoimmunity Joint Symposium with the European Federaion for Immunogeneics (EFI) Monday, September 3rd, 2018; 13:15-14:30; E104-107 Chairpersons: Elissaveta Naumova, Bulgaria & Mieke Boots, The Netherlands HLA and Solid Organ Transplantaion Frans Claas, The Netherlands HLA in Haematopoieic Stem Cell Transplantaion Katharina Fleischhauer, Germany HLA in Autoimmune Diseases Ludvig Sollid, Norway

JS.05 - Combinatorial approaches to develop targeted immunotherapeutics Joint Symposium with the Russian-Georgian Society Monday, September 3rd, 2018; 13:15-14:30; E102 Chairpersons: Revaz Sepiashvili, Russia & Yvete van Kooyk, The Netherlands Screening technologies for drug development. Alexander Gabibov, Russia The hallmark of smart agents: Immunotargeing & controlled release Sergey Deyev, Russia Novel insights into membrane targeing of B cell lymphoma: lessons learned from tetraspanins Annemiek van Spriel, Netherlands

JS.06 - From immunological insight to prevention of allergy Joint Symposium with the European Academy of Allergy and Clinical Immunology (EAACI) Tuesday, September 4th, 2018; 13:15-14:30; Elicium Chairpersons: Edward Knol, The Netherlands & Jürgen Schwarze, United Kingdom Liam O’Mahony, Ireland Microbial inducion of immune tolerance at mucosal surfaces Milena Sokolowska, Switzerland Immunoregulatory roles of lipid mediators in asthma and allergy Oscar Palomares, Spain Novel dendriic cell vaccines for the prevenion and treatment of allergic diseases

JS.07 - Subversion of phagocytosis in innate immunity: from efferocytosis to pathogen interaction Joint Symposium with the Society for Leukocyte Biology (SLB) Tuesday, September 4th, 2018; 13:15-14:30; Auditorium Chairpersons: Pieter Leenen, The Netherlands & Véronique Witko-Sarsat, France

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Tobias Dellenga, Germany Neutrophils as targets for host-directed therapy against tuberculosis Margarita Dominguez-Villar, United States of America Diferenial signaling through TLR7 or TLR8 determines the phenotype of human monocytes during RNA viral infecion Jusin Perry, United States of America Eferocytosis induces a novel SLC program to promote glucose uptake and lactate release

JS.08 - Cytometry Building Bridges Joint Symposium with the Internaional Society for Advanced Cytometry (ISAC) Tuesday, September 4th, 2018; 13:15-14:30; Forum Chairpersons: Hyun-Dong Chang, Germany & Andrea Cossarizza, Italy Cytometry of aging of the immune system Andrea Cossarizza, Italy Cytometry of intesinal microbiota Hyun-Dong Chang, Germany Standardizing cytometry of primary immunodeiciencies Tomas Kalina, Czech Republic

JS.09 - The gut microbiota and the IgA antibody production in health and disease Joint Symposium with the Society for Mucosal Immunology (SMI) Tuesday, September 4, 2018; 13:15-14:30; E104-107 Chairpersons: Oliver Pabst, Germany & Jo Spencer, United Kingdom IgA, microbiota and cancer Maria Rescigno, Italy Anibodies set boundaries limiing microbial metabolite penetraion and the resultant mammalian host response Andrew Macpherson, Switzerland The regulatory microenvironment in Peyer‘s patches leading to synchronized gut IgA responses Nils Lycke, Sweden

JS.10 - Innate host pathogen interactions Joint Symposium with the Japanese Immunology Society (JIS) Tuesday, September 4, 2018; 13:15-14:30; G106-107 Chairpersons: Esther de Jong, The Netherlands & Shimon Sakaguchi, Japan Sho Yamasaki, Japan Protecive role of Mincle in bacterial infecion Hisashi Arase, Japan LILR family receptors in host pathogen interacions Kazuyo Moro, Japan ILC2 and type 2 immune diseases

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 38 ECI2018 Hands-on Workshops Deep Thinking in Immunology Immunology is empowered by lots of data, with deep sequencing, cell populaion imaging, proteomics, high-throughput immune assays, or metabolomics as sources. In the past one would draw a scheme with perhaps 20 players on the blackboard, with arrows indicaing which inluences which, ‘up’ or ‘down’. Now there is many more (>75 000) molecular and cellular players, and it maters how much they go up or down, and when, and where. With the advent of deep data, our tradiional way of thinking falters: It does no jusice to the new opportuniies for idenifying the immunology in acion. We may need something like ‘deep thinking’. But what is deep thinking? The human brain is not it for thinking raionally about thousands of molecules at the same ime. But it can invoke a litle help from its friends. It is wise to befriend computers handling virtually unlimited numbers of data. They can analyze the data in many, many diferent ways, inding complex combinaions of the most complex paterns. Such data analysis has long been limited by focusing on a single level of cellular organizaion, e.g. the transcriptome, rather than on the dynamics of the enire, hierarchical network at stake. It has not been ‘deep’ data analysis, penetraing down through the various levels of cell acion. Computers can also empower mathemaical models that simulate immunological reality. For a long ime already, mathemaical modelling has played a big role in biology. It has helped appreciate the role of self-organizaion in developmental biology, synchronizaion of cellular oscillaions, fragiliies in the performance of metabolic and signal transducion pathways, and emergence of immunologically most relevant cell populaions. That modelling however, has not been ‘deep’ modelling. Most of those mathemaical models focused on concept rather than realism, and were small rather than ‘deep’. With systems biology and funcional genomics new types of both data analysis and modelling is developing, i.e. ones that try to integrate ‘all’ the relevant data into, thereby ‘deep’ (large), analyical and mathemaical models of reality. Married to the deep data, these models enhance understanding of reality rather than poteniality. They help test hypotheses in hard rather than sot ways. They upgrade the human mind, assisted by computers and systems biology, from tradiional to ‘deep’ thinking. This ‘deep thinking’ is not easy. It consitutes a challenge. First, one has to befriend computers and systems biology. And then one then has to converse with them paiently, so as to ensure that computer programs make sense immunologically. Aims and Objectives The objecives of the workshops are to: • Acquaint immunologists with some of the easy-to-use modelling sotware, which requires very litle mathemaics • Make immunologists use exising systems biology models to address some paradoxes in cell biology and to experience how modelling can forify the mind • Enable immunologists to access exising model repositories and interrogate many more exising models • Enable immunologists to integrate deep data onto such models

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 39 ECI2018

• Show immunologists how they could make and run their irst model • Befriend immunologists with some modelers Organization What is the imeline of the workshops? • Each workshop is set for 180 minutes • Introductory lecture of 20 minutes; explanaion of the logisics of the workshop; scieniic introducion to the topic • Hands-on for 150 minutes, i.e. the paricipants will themselves model or analyze data on their own PC (pear or apple) on the basis of a ‘recipe’ for modelling, using sotware, models, and ‘Big Data’ that will be pre-supplied beforehand • Concluding lecture of 10 minutes; telling what paricipants can now do with this • Onsite assistants will be available to support paricipants during the whole ime of the workshops What do I need to bring to the workshops? • Laptop with USB port (apple or ear (=PC)), good mood and a profound interest in immunology and its complexiies. • Paricipants will be asked to download the pre-supplied material onto their PC well before the ECI. They will obtain the necessary password and link upon pre-conference registraion for the workshop. How do I register for the workshops? • Sill a few places are open for workshops M3 and D3. • To register for one of these workshops approach our onsite registraion desk. • Each paricipant may only register for one of the six workshops. • We will charge EUR 15 per workshop/icket. Workshop Schedule Presenters: Hans Westerhof (Workshop A) and Yang Li (Workshop B) Workshop A: Dynamic Modelling M1: Beginners Paradoxes in fully intracellular booked! Sepimmune 3 signalling 08:30-11:30 M2: Advanced Immune cell fully networks: booked! Sepchronic 4 versus 14:45-17:45acute inlammaion M3: Advanced Making sense of omics data using genome wide metabolic maps Sep 5 08:30-11:30 Workshop B: Analyzing of Big Data D1: Beginners fully booked! Integraing Sep ime-dependent3 14:45-17:45RNA-seq with public data D2: Advanced Integraing muli-omics fully with booked! Sepimmune 4 parameters 08:30-11:30 D3: Advanced Integraing omics and immunological parameters with geneic variants Sep 5 12:00-15:00

Beginners: People who are interested but have not yet pracised. Advanced: People who have essenially already done the „For Beginner“ bit in their own pracice.

All hands-on workshopsD203-204 . take place in Room

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 40 ECI2018 Educational Sessions EDU.01 - Systems Biology for Immunology: Help with the Complexity Immunology must be the most complex science of all: myriads of molecules in highly complex networks. This session demonstrates how the new ‘deep (i.e. modelling assisted) thinking’ may help integrate the big data into understanding, of health and disease. Sunday, September 2nd, 2018; 16:30-17:45; Forum Chairpersons: Peter Brodin, Sweden & Mateo Barberis, The Netherlands Big Data in Immunology: How to make the most of it Yang Li, The Netherlands The Complexity of Immunology: Do T Cells throw dice? Thomas Höfer, Germany Systems Immunology: Making sense of the Yins and Yangs Hans Westerhof, The Netherlands EDU.02 - The Utility of Theories in Immunology In the complex science of immunology, theory has a powerful role in shaping hypotheses that dictate routes of experimental invesigaion, whose results shape our understanding of the immune system. This Educaional Session will illustrate this by considering four contemporary theories that take into account processes, mechanisms and rules governing immune reacions. Monday, September 3rd, 2018; 10:15-11:30; Forum Chairpersons: Adrian Hayday, United Kingdom & Hans Yssel, France The Validaion Theory in Immunology Adrian Hayday, United Kingdom The „two-niche“ theory of T cell memory Francesca Di Rosa, Italy The Disconinuity Theory of Immunity Eric Vivier, France & Thomas Pradeu, France The Equilibrium Model of Immunity Gérard Eberl, France EDU.03 - Immunology of extracellular vesicles Extracellular vesicle research represents a rapidly growing ield in biomedicine. This Educaional Session focusing on extracellular vesicles will provide basic insight to the ield, give a few guidelines how to address methodological challenges, highlight perspecives and give examples for experimentally conirmed roles of extracellular vesicles in immunity. Monday, September 3rd, 2018; 13:15-14:30; G104-105 Chairpersons: Marca Wauben, The Netherlands & Edit Buzas, Hungary Extracellular vesicles in acute and chronic inlammaion Edit Buzas, Hungary Isolaion and detecion of extracellular vesicles Rienk Nieuwland, The Netherlands Extracellular vesicles in immunity Susanne Gabrielsson, Sweden

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 41 ECI2018 Men and Women in Immunology MWI.01 Men and Women in Immunology Monday, September 3rd, 2018; 08:30-09:45, Forum Chairpersons: Anna Fogdell-Hahn (Sweden), Chrisina Helbig (The Netherlands), Peter Openshaw (United Kingdom) 08:30 Opening & Introducion 08:35 News about career challenges for immunologists: examples from UK Peter Openshaw, United Kingdom 08:45 Athena SWAN: does the program work for women, men or both? Catherine Williamson, United Kingdom 09:10 Gender and power: focus on problemaic masculinity as privileges Jesper Fundberg, Sweden 09:35 General Discussion

The “Women in Immunology” session has been included in several ECI meeings, as a way to deal with gender inequality issues in the immunology ield and in academia in general. But is this really a quesion about women? This year’s session will challenge that view. Staisics show that the gender inequality is indeed sill an issue we need to work with and professor Peter Openshaw will present the results from a quesionnaire about gender diferences in carreer opportuniies in the immunology ield. In the UK they made a sincere efort to deal with the gender inequality and started the Athena Swan program that required the universiies to document their eforts to bridge the gender gap in academy to be eligible for research grants from the government. Professor Catherine Williamson will present the results from a paper that studied the impact of the Athena Swan program on staf within a UK University. Finally, we will turn the focus on gender as a power issue and have Dr. Jepser Fundberg, studying men behavior in sports, to give his analysis of how masculinity is associated with privileges and power. We are happy to invite you to come with your suggesions of how to beter target this issue in the future and will write a summary of this session to be published in the European Journal of Immunology. All registered congress delegates can paricipant in this session for free. No seperate registraion is required.

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 42 Sunday, September 2nd, 2018 ECI2018 Keynote Lectures KL.01 Serendipities of acquired immunity Tasuko Honjo, Japan Sunday, September 2, 2018; 15:30-16:15; Elicium Chairpersons: Barbara Bohle, Austria & Cornelius Melief, The Netherlands Dr. Honjo is well known for his discovery of acivaion-induced cyidine deaminase that is essenial for class switch recombinaion and somaic hypermutaion. He has established the basic conceptual framework of class switch recombinaion. In addiion, he discovered PD-1 (program cell death 1), a negaive coreceptor at the efector phase of immune response and showed that PD-1 modulaion contributes to treatments of tumor, viral infecion and autoimmunity. For these contribuions, Dr. Honjo has received many awards, including Imperial Prize, Japan Academy Prize, Robert Koch Prize, Order of Culture, the Tang Prize, William B. Coley Award, Richard V. Smalley, MD Memorial Award, the Kyoto Prize, the Keio Medical Science Prize, Warren Alpert Foundaion Prize and Japan Bioindustry Award. Elected as a foreign associate of Naional Academy of Sciences, USA, as a member of the German Academy of Natural Scienists, and also as a member of Japan Academy. KL.02 Trained immunity: reprogramming innate immunity to protect against infections This Keynote Lecture is a Van Loghem Lecture. Mihai Netea will be honored with the Van Loghem Award at the end of the lecture. Mihai Netea, Netherlands Sunday, September 2, 2018; 15:30-16:15; Auditorium Chairpersons: Markus Kleinewiefeld, Belgium & Lorenzo Moreta, Italy Mihai Netea was born and studied medicine in Cluj-Napoca, Romania. He completed his PhD at the Radboud University Nijmegen, The Netherlands, on studies invesigaing the cytokine network in sepsis. Ater working as a post-doc at the University of Colorado, he returned to Nijmegen where he inished his clinical training as an infecious diseases specialist, and where he currently heads the division of Experimental Medicine, Department of Internal Medicine, Nijmegen University Nijmegen Medical Center. He is mainly interested in understanding the factors inluencing variability of human immune responses, the biology of sepsis and immunoparalysis, and the study of the memory traits of innate immunity.

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 43 Monday, September 3rd, 2018 ECI2018

KL.03 Centrosomes and exosomes: Molecular pacemakers of immune synapse and T cell activation Francisco Sánchez-Madrid, Spain Monday, September 3, 2018; 12:00-12:45; Elicium Chairpersons: Anna Fogdell-Hahn, Sweden & Catherine Sautès-Fridman, France Francisco Sánchez-Madrid has made leading contribuions to knowledge about the mechanisms of leukocyte adhesion, polarity, migraion and acivaion. This contribuion has pioneered the ideniicaion and characterizaion of the irst families of leukocyte adhesion molecules, their physiological role in the control of migraion and cellular traic, and their immense relevance to chronic inlammatory pathologies. His laboratory research on migraion and acivaion receptors of human leukocytes is documented in more than 400 publicaions in internaional journals, including many recent aricles in presigious journals that have to date received more than 27.000 citaions.In the most recent years, his research group has made contribuions to understanding the funcional relevance of the supra-molecular organizaion of leukocyte and endothelial nano-plaforms connected to cytoskeleton in the regulaion of cell-to-cell communicaion in the immune system and the mechanisms of transfer of geneic informaion. KL.04 Co-ordination of the local and systemic immune response to infection and injury Judi Allen, United Kingdom Monday, September 3, 2018; 12:00-12:45; Auditorium Chairpersons: Pablo Engel, Spain & Anna Puel, France Judi Allen obtained her PhD from the University of California, Berkeley following several years in the Biotech Industry. Judi moved to Imperial College, London for her postdoc where she began work on the immune response to helminths, which as remained the focus of her research career. In 1997, Judi established her own group at the University of Edinburgh with an MRC Senior Fellowship and became Professor of Immunobiology in 2005. Recently, Judi joined the Faculty of Biology, Medicine & Health at the University of Manchester. Judi is a Fellow of the Royal Society of Biology, the Royal Society of Edinburgh and the Academy of Medical Sciences. She is best known for her work on the biology of macrophages in the context of macroparasite infecion and is paricularly interested in the relaionship of type 2 immunity to wound repair pathways.

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 44 Tuesday, September 4th, 2018 ECI2018

KL.05 Regulatory T cell homeostasis Adrian Liston, Belgium Tuesday, September 4, 2018; 12:00-12:45; Elicium Chairpersons: Winfried Pickl, Austria & Rene Toes, The Netherlands Adrian Liston is Professor of Translaional Immunology at the University of Leuven and the VIB, Belgium. The laboratory works on both aspects of discovery immunology (idenifying intervenion- points in regulatory T cell biology; developing diabetes pre- clinical models) and applied immunology (human immunology; immunogeneics; and mechanisms of immunodeiciency and inlammatory disease). He has been awarded the Francqui Chair, Eppendorf prize and two ERC grants, among other honours. His PhD research was on T cell tolerance and diabetes with Professor Chris Goodnow at the Australian Naional University, followed by post-doctoral research on regulatory T cell biology with Professor Sasha Rudensky at the University of Washington. In 2009 Adrian was invited to set up an independent research laboratory at the VIB and the University of Leuve. KL.06 T cell metabolism Erika Pearce, Germany Tuesday, September 4, 2018; 12:00-12:45; Auditorium Chairpersons: Janneke Samsom, The Netherlands & Ulrich Steinhof, Germany Dr. Pearce completed her doctoral training at the University of Pennsylvania in Philadelphia, focusing on the regulaion of T cell responses during infecion. She coninued her postdoctoral studies at the University of Pennsylvania and it was during this ime she began her research into how cellular metabolic processes govern the immune response to infecion and cancer. In 2009 Dr. Pearce began her independent research career as an Assistant Member at the Trudeau Insitute in Saranac Lake, NY. In 2011 she joined the faculty at Washington University in St. Louis and was promoted to Associate Professor in 2014. In September 2015, Dr. Pearce became a Director at the Max Planck Insitute for Immunobiology and Epigeneics in Freiburg, Germany and Head of the Department of Immunometabolism. Her research coninues to invesigate the metabolic pathways in immune cells with a view to targeing these pathways for therapy.

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KL.07 The unsuspected role of gut microbiota in cancer therapeutics Laurence Zitvogel, France Wednesday, September 5, 2018; 15:45-16:30; Elicium Chairpersons: Jacques Neejes,The Netherlands & Jessica Strid, United Kingdom Pr L. Zitvogel, MD (clinical oncology), PhD (tumor immunology), PU- PH Faculty Paris Sud, University Paris XI (Clinical Biology), graduated in Medical Oncology from the School of Medicine of the University of Paris in 1992. She started her scieniic career when she was at the University of Pitsburgh in the USA in Michael Lotze’s laboratory. She became Research Director at Insitut Naional de la Santé et Recherche Médicale U1015, and Scieniic Director of the Immuno- Oncology programm at Gustave Roussy, the largest cancer Center in Europe. She has been acively contribuing to the ield of cancer immunology and immunotherapy, and she brought together basic and translaional research, including the design of cancer therapies through combined animal studies and Phase I/II paient trials. Her experise is mainly dendriic cell and innate efector biology and relevance during tumour development as well as exosome-based vaccine designs. She pioneered the concept of immunogenic cell death and showed that chemotherapy, radiotherapy and inhibitors of tyrosine kinase mediate their tumoricidal acivity, at least partly through the immune system. Her team discovered the criical role and impact of gut microbiota in cancer immunosurveillance and therapies. She was the recipient of many awards including the Naional Academy of Medicine, the Translaion Research INSERM Prize, the ASCO-SITC, the Brupbacher Awards 2017 and the ESMO Immuno-Oncology Award 2017. KL.08 The maintenance and mobilization of resident immune memory cells Andreas Radbruch, Germany Wednesday, September 5, 2018; 15:45-16:30; Auditorium Chairpersons: Deborah Dunn-Walters, United Kingdom & Marieke van Ham, The Netherlands Andreas Radbruch, a biologist by educaion, is Director of the German Rheumaism Research Center in Berlin, a Leibniz Insitute, and Professor of Rheumatology at the Charité University Medicine and the Humboldt University of Berlin. His research aims at a molecular understanding of (chronic) immune reacions and immunological memory. He originally described targeing of anibody class switch recombinaion by switch transcripts, ideniied memory plasma cells, their maintenance in dedicated bone marrow niches, and recently the bone marrow as the home also of resident and resing memory T lymphocytes, maintaining memories to systemic anigens. This work has ideniied memory plasma cells secreing pathogenic anibodies, and memory T cells adapted to chronic immune reacions as novel targets in immune-mediated diseases, like chronic inlammatory diseases and allergy, and paved the way for novel, cell-directed therapeuic strategies. His group also has developed cytometric technologies, most notably the MACS technology and the cytometric secreion assay. Andreas Radbruch has received the Carol Nachman Prize for Rheumatology, the Avery Landsteiner Award, and an ERC Advanced Grant. He is member of EMBO and of the German Academy of Science.

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 46 Sunday, September 2nd, 2018 ECI2018 Oral Sessions, Sunday, September 2nd, 2018 Keynote Lectures (details p. 42) KL.01 Keynote Lecture 01 15:30 - 16:15 Elicium Chairpersons: Barbara Bohle, Austria & Cornelius Melief, The Netherlands KL.01 Serendipiies of acquired immunity Tasuko Honjo, Japan KL.02 Keynote Lecture 02 15:30 - 16:15 Auditorium Chairpersons: Markus Kleinewiefeld, Belgium & Lorenzo Moreta, Italy KL.02 Trained immunity: reprogramming innate immunity to protect against infecions Mihai Netea, Netherlands This Keynote Lecture is a Van Loghem Lecture. Mihai Netea will be honored with the Van Loghem Award at the end of the lecture. Late Breaking Hot Topics HT.01 Late Breaking Hot Topic 01 15:15 - 15:30 Elicium Chairpersons: Barbara Bohle, Austria & Cornelius Melief, The Netherlands HT.01.01 Ani-NKG2A mAb is a checkpoint inhibitor that promotes ani-tumor immunity by unleashing both T and NK cells E. Vivier, P. André, Marseille, France HT.02 Late Breaking Hot Topic 02 15:15 - 15:30 Auditorium Chairpersons: Markus Kleinewiefeld, Belgium & Lorenzo Moreta, Italy HT.02.01 Self-Maintaining Gut Macrophages are Essenial for Intesinal Homeostasis S. De Schepper, S. Verheijden, J. Aguilera-Lizarraga, M. Viola, W. Boesmans, N. Stakenborg, I. Voytyuk, I. Smidt, B. Boeckx, I. Dierckx de Casterlé, V. Baekelandt, E. Gonzalez Dominguez, M. Mack, I. Depoortere, B. De Strooper, B. Sprangers, U. Himmelreich, S. Soenen, M. Guilliams, P. Vanden Berghe, E. Jones, D. Lambrechts, G. Boeckxstaens, Leuven, Belgium Workshops Track A WS.A1.01 Myeloid lineage speciicaions 16:30 - 17:45 G106-107 Chairpersons: Emma Chambers, United Kingdom & Björn Clausen, Germany WS.A1.01.01 Tissue resident mast cells are of dual hematopoieic origin R. Gentek, Marseille, France WS.A1.01.02 Determining dendriic cell ontogeny across organs by cellular barcoding T. Tak, A. Magniez, L. Perié, Paris, France WS.A1.01.03 Bone marrow-resident dendriic cells play an important role in ani-fungal immunity by boosing granulopoiesis upon recogniion of yeast paricles. M. Goedhart, E. Slot, M. F. Pascui, S. Geerman, T. Rademakers, B. Nota, C. Voermans, M. A. Nolte, Amsterdam, Netherlands WS.A1.01.04 Common monocyte progenitors are novel animycobacterial efector cells P. Henneke, A. Lösslein, Freiburg, Germany WS.A1.01.05 Ideniicaion of the unique funcional phenotype of iMATE-deining monocytes that drive hepaic T cell proliferaion K. Pawelka, P. Knolle, M. Heikenwälder, Munich, Germany WS.A1.01.06 C/EBPα is crucial in early dendriic cell development A. Muralikrishnan, A. Rosenberger, E. Schwarzenberger, H. Strobl, A. Zebisch, H. Sill, A. Wöller, Graz, Austria WS.A5.01 Innate efectors in the onset of immune responses 16:30 - 17:45 G104-105 Chairpersons: Helena Erlandsson-Harris, Sweden & Cecilia Garlanda, Italy WS.A5.01.01 Inlammaion-induced cancer and cancer-induced inlammaion in colon: a role for S1P lyase A. Schwiebs, M. Herrero, E. Wiercinska, M. Anlauf, F. Otenlinger, K. Schmidt, D. Thomas, E. Elwakeel, A. Weigert, H. Bonig, K. Scholich, G. Geisslinger, J. M. Pfeilschiter, H. H. Radeke,

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 47 Sunday, September 2nd, 2018 ECI2018

Frankfurt, Germany WS.A5.01.02 CD28 co-simulaion during anigenic recall responses of CD4+Th1 cells triggers IFNg secreion in vivo S. Haack, D. Langenhorst, F. Lühder, T. Hünig, N. Beyersdorf, Würzburg, Germany WS.A5.01.03 Blood transcriptomic analysis shows how recall innate responses are modulated by the use of an adjuvant at priming E. Peini, F. Santoro, D. Kazmin, A. Ciabaini, F. Fiorino, G. Gilillan, I. Evenroed, P. Andersen, G. Pozzi, D. Medaglini, Siena, Italy WS.A5.01.04 DNGR-1 dampens neutrophil recruitment to damaged issues, fostering disease tolerance upon infecion C. Del Fresno Sánchez, P. Saz-Leal, M. Enamorado, S. Wculek, S. Marínez-Cano, N. Blanco- Menéndez, O. Schulz, M. Gallizioli, F. Miró, E. Cano, A. Planas, C. Reis e Sousa, D. Sancho, Madrid, Spain WS.A5.01.05 Toll-like receptor signalling induces a temporal switch from inlammatory towards a more resolving lipid proile in monocyte-derived macrophages J. von Hegedus, M. Heijink, T. Huizinga, M. Kloppenburg, M. Giera, R. Toes, A. Ioan-Facsinay, Leiden, Netherlands WS.A5.01.06 OX40 is required for both Th17 and Th1 efector T cell programmes D. Gajdasik, C. Willis, R. Fiancete, M. Boto, T. Vyse, G. Frankel, D. Ruano-Gallego, D. Withers, Birmingham, United Kingdom Workshops Track B WS.B2.01 Environmental regulaion of ani-tumor responses 16:30 - 17:45 G102-103 Chairpersons: Joanne Lysagh, Ireland & Duygu Sag, Turkey WS.B2.01.01 High glycolyic tumors evade immune destrucion by acidosis-dependent inducion of ICER in tumor-associated macrophages T. Bohn, S. Rapp, M. Klein, S. Pektor, K. Renner, M. Kreutz, V. Popp, K. Gerlach, B. Weigmann, C. Lueckel, M. Huber, C. Becker, E. von Stebut-Borschitz, H. Schild, E. Schmit, T. Bopp, Mainz, Germany WS.B2.01.02 Carcinoma-associated pancreaic stellate cells induce CD4+ and CD8+ T-cell exhausion L. Gorchs, C. Fernández Moro, Q. Meng, E. Rangelova, H. Kaipe, Stockholm, Sweden WS.B2.01.03 The tumour microenvironment supports the self-renewal of tumour-promoing macrophages in colon adenoma I. Soncin, J. Sheng, Q. Chen, K. Karjalainen, C. Ruedl, Singapore, Singapore WS.B2.01.04 Faty acid metabolism complements glycolysis in the selecive regulatory T cell expansion during tumor growth I. Pacella, C. Procaccini, C. Focaccei, S. Miacci, E. Timperi, D. Faicchia, M. Severa, F. Rizzo, E. M. Coccia, F. Bonacina, N. Mitro, G. D. Norata, G. Rossei, V. Ranzani, M. Pagani, E. Giorda, Y. Wei, G. Matarese, V. Barnaba, S. Piconese, Rome, Italy WS.B2.01.05 IL-18 is a key driver of immunosuppression and a therapeuic target in muliple myeloma S. Kassem, K. Nakamura, H. Avet-Loiseau, M. J. Smyth, L. Marinet, Toulouse, France WS.B2.01.06 Chronic lymphocyic leukemia impairs metabolic itness in CD8 T cells A. van Bruggen, A. Martens, J. A. Fraieta, M. Levin, P. J. Siska, S. Endstra, J. C. Rathmell, J. J. Melenhorst, A. P. Kater, G. J. van der Windt, Amsterdam, Netherlands Symposia and Workshops Track C S.C1 Maintenance and local regulaion of issue speciic immunity 16:30 - 17:45 Auditorium Chairpersons: Muzlifa Hanifa, United Kingdom & Hans-Willi Mitrücker, Germany S.C1.01 Context- and Mucosa-speciic Regulaion of Immunity and Tolerance by Regulatory T Cells Tobias Bopp, Germany S.C1.02 Funcions of Resident Memory T Cells David Masopust, United States S.C1.03 Acivaion of Ca2+ regulated pathways downstream of Patern Recogniion Receptors Francesca Granucci, Italy

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WS.C4.01 Manipulaion of tolerogenic pathways 16:30 - 17:45 E102 Chairpersons: Nathalie Cools, Belgium & Jona Freysdoir, Iceland WS.C4.01.01 PD-1 regulates the expression of HELIOS in self-reacive CD8+ and CD4-CD8-T cells N. Rodriguez Rodriguez, S. A. Apostolidis, E. Montes Servin, O. Arrieta, G. C. Tsokos, F. Rosei, J. C. Crispin, Mexico City, Mexico WS.C4.01.02 Immunotherapy with apitopes® blocks the immune response to thyroid simulaing hormone receptor in HLA- DR transgenic mice E. Schurgers, F. La Greca, D. C. Wraith, K. F. Marin, L. Jansson, Diepenbeek, Belgium WS.C4.01.03 Pathogenic anibody development and blister formaion due to impaired peripheral tolerance S. Haeberle, X. Wei, K. Bieber, S. Goletz, E. Schmidt, R. Ludwig, A. Enk, E. Hadaschik, Heidelberg, Germany WS.C4.01.04 APRIL induces a novel subset of IgA+ regulatory B cells that suppress inlammaion through the expression of IL-10 and PD-L1 C. M. Fehres, N. O. Van Uden, N. G. Yeremenko, L. Fernandez, G. Franco Salinas, L. M. Van Duivenvoorde, B. Huard, J. Morel, H. Spits, M. Hahne, D. L. Baeten, Amsterdam, Netherlands WS.C4.01.05 Molecular Mechanisms of T cell Tolerance Inducion S. T. H. Ng, S. Bevington, P. Cockerill, D. C. Wraith, Birmingham, United Kingdom WS.C4.01.06 Macrophages treated with exosome-delivered miRNA-150 release immune suppressive exosome-like nanovesicles bearing anigen/MHC complex K. Nazimek, B. Nowak, M. Wasik, W. Ptak, P. W. Askenase, K. Bryniarski, Krakow, Poland Workshops Track D WS.D4.01 Protecive mechanisms for microbial pathogens 16:30 - 17:45 E104-107 Chairpersons: Marielle Haks, The Netherlands & Miloslav Kverka, Czech Republic WS.D4.01.01 Diferent composiion and funcional properies of splenic T cells in experimental cerebral malaria-suscepible C57BL/6 wildtype and protected Ifnar1-/- mice J. J. Reichwald, P. J. Korir, L. Jenster, A. Mueller, A. Hoerauf, B. Schumak, Bonn, Germany WS.D4.01.02 A disinct subset of human CD56+ cells present at baseline in HbAS-SCT-children is associated with a lower parasite density during an episode of clinical malaria C. Loiseau, O. K. Doumbo, B. Traore, J. L. Brady, C. Proiei, P. D. Crompton, D. L. Doolan,, Cairns, Australia WS.D4.01.03 Transcripion factor T-bet plays a complex role in B cell mediated immune response against Plasmodium infecion M. Akkaya, P. W. Sheehan, C. K. Cimperman, B. P. Theall, M. Pena, S. K. Pierce, Rockville, United States WS.D4.01.04 Within host-adaptaion of Bordetella pertussis under vaccine immune pressure E. van Schuppen, A. Zeddeman, K. E. Kok, M. van Gent, K. J. Heuvelman, M. J. Bart, H. G. van der Heide, F. J. van Opzeeland, S. van Selm, M. I. de Jonge, R. de Groot, F. R. Mooi, D. A. Diavatopoulos, Nijmegen, Netherlands WS.D4.01.05 Transphagocytosis, a novel mechanism for bacterial uptake by B cells R. García Ferreras, G. Ramírez Saniago, A. Cruz Adalia, J. Osuna Pérez, M. Torres Torresano, Y. R. Carrasco, E. Veiga Chacón, Madrid, Spain WS.D4.01.06 Human vaginal and skin dendriic cell subsets control ZIKA virus infecion J. Eder, T. B. Geijtenbeek, Amsterdam, Netherlands Symposia Track E S.E1 Visualizing immune responses 16:30 - 17:45 Elicium Chairpersons: Burkhard Ludewig, Switzerland & Reina Mebius, The Netherlands S.E1.01 Cancer assassins: the secrets of serial killers Gillian Griith, United Kingdom S.E1.02 Neuronal regulaion of innate lymphoid cells Henrique Veiga Fernandez, Portugal S.E1.03 Spaiotemporal dynamics of CD8+ T cells undergoing intrahepaic priming Mateo Iannacone, Italy

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Educational Sessions (details p. 40) EDU.01 Systems Biology for Immunology: Help with the Complexity 16:30 - 17:45 Forum Chairpersons: Peter Brodin, Sweden & Mateo Barberis, The Netherlands EDU.01.01 Big Data in Immunology: How to make the most of it Yang Li, The Netherlands EDU.01.02 The Complexity of Immunology: Do T Cells throw dice? Thomas Höfer, Germany EDU.01.03 Systems Immunology: Making sense of the Yins and Yangs Hans Westerhof, The Netherlands

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 50 Monday, September 3rd, 2018 ECI2018 Oral Sessions, Monday, September 3rd, 2018

Keynote Lectures (details p. 43) KL.03 Keynote Lecture 03 12:00 - 12:45 Elicium Chairpersons: Anna Fogdell-Hahn, Sweden & Catherine Sautès-Fridman, France KL.03 Centrosomes and exosomes: Molecular pacemakers of immune synapse and T cell acivaion Francisco Sánchez-Madrid, Spain KL.04 Keynote Lecture 04 12:00 - 12:45 Auditorium Chairpersons: Pablo Engel, Spain & Anna Puel, France KL.04 Co-ordinaion of the local and systemic immune response to infecion and injury Judi Allen, United Kingdom Late Breaking Hot Topics HT.03 Late Breaking Hot Topic 3 11:45 - 12:00 Elicium Chairpersons: Anna Fogdell-Hahn, Sweden & Catherine Sautès-Fridman, France HT.02.01 The transcripion factor ZEB2 is required to maintain the issue-speciic ideniies of macrophages C.L. Scot, Ghent, Belgium HT.04 Late Breaking Hot Topic 4 11:45 - 12:00 Auditorium Chairpersons: Pablo Engel, Spain & Anna Puel, France HT.04.01 Smoking induces recruitment of monocytes into the alveolar space and contributes to accelerated growth of Mycobacterium tuberculosis B. Corleis, J. L. Cho, A. Linder, A. Yan, A. Dickey, A. E. Schif, B. D. Medof, D. S. Kwon, Cambridge, United States Symposia and Workshops Track A S.A1 Myeloid lineage speciicaion 8:30 - 9:45 Auditorium Chairpersons: William Agace, Denmark & Ed Lavelle, Ireland S.A1.01 Consequences of anigen presening cell networks in the skin Muzlifah Hanifa, United Kingdom S.A1.02 The power of ONE: Immunology in the age of single cell genomics Ido Amit, Israel S.A1.03 The macrophage niche: in search of the issue-speciic signals controlling macrophage development Marin Guilliams, Belgium S.A2 Immune development and aging from the cradle to the grave 14:45 - 16:00 Forum Chairpersons: Nuno Alves, Portugal & Ricardo Pujol-Borrel, Spain S.A2.01 Dissecing blood and immune cell lineages by endogenous barcoding Hans Reimer Rodewald, Germany S.A2.02 Implicaions from monogenic autoimmunity Kai Kisand, Estonia S.A2.03 Strategies for enhancing human immunity during ageing Arne Akbar, United Kingdom S.A3 Immunomonitoring and biomarkers 16:30 - 17:45 Forum Chairpersons: Chrisine Falk, Germany & Barbaros Oral, Turkey S.A3.01 Protecive vaccinaion against respiratory viruses Peter Openshaw, United Kingdom S.A3.02 Biomarkers for allergen-speciic immunotherapy

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Marianne van Hage, Sweden S.A3.03 CD Maps - anigen density measurements of CD1-CD100 on human lymphocytes and thymocytes Tomas Kalina, Czech Republic BS.A.01 Bright Sparks Workshop 10:15 - 11:30 Elicium Chairpersons: Barbara Bohle, Austria & Thomas Riter, Ireland BS.A.01.01 Developmental origin of osteoclasts and their funcional maintenance by nuclear chimerism E. Mass, C. J. Jacome-Galarza, G. I. Percin, T. Lazarov, J. Eitler, M. Rauner, L. Crozet, M. Bohm, C. Waskow, F. Geissmann, Bonn, Germany BS.A.01.02 Uncovering the regulatory T cell transcripional signature in the human thymus M. Ângelo-Dias, A. Godinho-Santos, Y. Tokunaga, A. Serra-Caetano, H. Nunes-Cabaço, A. E. Sousa, A. A. Raposo, Lisbon, Portugal BS.A.01.03 Human T-bet+ B cells: inducion and efector funcions from a muliple sclerosis perspecive J. van Langelaar, L. Rijvers, M. Janssen, I. de Groot, L. Kalden, A. F. Wierenga-Wolf, S. Koetzier, T. A. Siepman, H. E. de Vries, P. Unger, M. S. van Ham, R. Q. Hintzen, M. M. Luijn, Roterdam, Netherlands BS.A.01.04 Extracellular Vesicles derived from licensed Mesenchymal Stem Cells: a tunable approach to regulate inlammatory angiogenesis R. Angioni, S. Herkenne, C. Liboni, R. Sanchez-Rodriguez, B. Calì, G. Borile, A. Viola, Padova, Italy BS.A.01.05 Lymph node stromal cell funcion upon immune acivaion is modulated by dynamics between podoplanin and its binding partners on the plasma membrane C. M. de Winde, A. C. Benjamin, L. Millward, V. G. Marinez, S. E. Acton, London, United Kingdom BS.A.01.06 Autoimmune associated gene PTPN22 is a novel negaive regulator of dendriic cell homeostasis and funcion H. A. Purvis, F. Clarke, G. H. Cornish, T. J. Peel, C. Sanchez-Blanco, D. J. Rawlings, R. Zamoyska, P. Guermonprez, A. P. Cope, London, United Kingdom WS.A4.01 Germinal center reacions 8:30 - 9:45 E104-107 Chairpersons: Stefania Bjarnarson, Iceland & Hans-Marin Jäck, Germany WS.A4.01.01 Follicular dendriic cells originate from subepithelial mesenchymal cells in Peyer’s patches A. Prados, V. Koliaraki, G. Kollias, Vari, Greece WS.A4.01.02 Novel branched proximity hybridizaion assay to quanify nanoscale protein-protein interacion S. Zheng, M. Miterer, M. Reth, M. Cavallari, J. Yang, Freiburg, Germany WS.A4.01.03 Reconsituion of T-cell synapic ectosomes unravels vesicular CD40L density as a criical determinant in the feed forward acivaion of anigen presening cells P. F. Céspedes-Donoso, D. G. Saliba, S. Valvo, S. Balint, K. Korobchevskaya, E. Compeer, M. Tognolli, E. O´Neill, M. L. Dusin, Oxford, United Kingdom WS.A4.01.04 In follicular regulatory T cells NFATc1 is essenial for homing to germinal centers A. Koenig, M. Vaeth, G. Müller, S. Klein-Hessling, M. Klein, D. Stauss, L. Dietz, T. Bopp, M. Lipp, I. Berberich, F. Berberich-Siebelt, Würzburg, Germany WS.A4.01.05 Ectopic lung resident germinal centres are formed during chronic house dust mite driven allergic airway disease in a T follicular helper cell dependent manner F. I. Uwadiae, R. Siroya, A. Gerasimov, C. Spilsbury, C. J. Pyle, S. A. Walker, C. M. Lloyd, J. A. Harker, London, United Kingdom WS.A4.01.06 Anigen simulaion of lymphoid cells supports alternaive pathway of T Follicular helper cell difereniaion by polarizing CD45RA- CD4 T cells into Th cells R. Jeger-Madiot, M. Pereira, C. Richeta, V. Quiniou, P. Bufet, D. Klatzmann, A. Moris, S. Graf- Dubois, Paris, France WS.A6.01 Lessons learned from geneic defects 8:30 - 9:45 E102 Chairpersons: Alfredo Correll, Spain & Peter Darlington, Canada WS.A6.01.01 CLIP upregulaion on B cells associates with muliple sclerosis onset and is governed by autoimmunity risk allele CLEC16A L. Rijvers, M. Melief, M. Stéphant, J. van Langelaar, R. M. van der Vuurst de Vries, A. F. Wierenga-Wolf, M. van Ham, R. Q. Hintzen, M. M. van Luijn, Roterdam, Netherlands WS.A6.01.02 CD55deicientpaient PBMCs respond diferenially to TLR, Inlammasome and paient 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 52 Monday, September 3rd, 2018 ECI2018

exosome simulaion before and ater Eculizumab therapy. G. G. Kaya, M. Yildirim, I. Evcili, N. Bozbeyoglu, I. C. Ayanoglu, A. Ozen, S. Sari, B. Dalgic, M. Gursel, I. Gursel, Ankara, Turkey WS.A6.01.03 A Th17 cell speciic migraion defect provides protecion from EAE in DOCK8 deicient mice A. S. Wilson, H. Law, C. B. Knobbe-Thomsen, C. J. Kearney, J. Oliaro, C. Binsfeld, G. Burgio, L. Starrs, D. Brenner, K. L. Randall, A. Brüstle, Canberra, Australia WS.A6.01.04 Consequences of an IL2RA locus duplicaion in a very early onset inlammatory bowel disease paient M. E. Joosse, F. Charbit-Henrion, R. C. Raatgeep, D. J. Lindenbergh-Kortleve, L. M. Costes, S. Nugteren, S. Veenbergen, V. Malan, J. K. Nowak, M. Mearin, J. C. Escher, N. Cerf-Bensussan, J. N. Samsom, Roterdam, Netherlands WS.A6.01.05 Coincidence of a novel NFKB1 mutaion with a Crohn-associated NOD2 rare variant in a paient may explain her profound common variable immunodeiciency (CVID) phenotype with unusually severe gastrointesinal manifestaions. M. Marinez-Gallo, R. Dieli-Crimi, C. Franco-Jarava, M. Antolin, L. Blasco, P. Paramonov, A. Álvarez Fernández, X. Molero, J. Velázquez, A. Marín-Nalda, R. Pujol-Borrell, R. Colobran, Barcelona, Spain WS.A6.01.06 Tetratricopepide repeat domain 7 a regulates haematopoieic stem cell funcions by controlling the stress-induced response. C. Leveau, M. El-Daher, N. Cagnard, A. Fischer, G. de Saint Basile, F. Sepulveda, Paris, France WS.A3.01 Immunobiomarkers in autoimmunity and beyond 10:15 - 11:30 G102-103 Chairpersons: Karine Chemin, Sweden & Leendert Trouw, The Netherlands WS.A3.01.01 Dissecing IL-12p70 response variability in health and disease C. Posseme, B. Charbit, A. Llibre, A. Bisiaux, B. Piasecka, E. Nemes, T. Scriba, L. Quintana-Murci, S. Pol, M. L. Albert, D. Dufy, Paris, France WS.A3.01.02 New protein array technology ideniies rituximab treated non responder rheumatoid arthriis paients are generaing a new autoanibody repertoire Z. Konthur, M. Wiemkes, T. Häupl, G. Burmester, K. Skriner, Berlin, Germany WS.A3.01.03 Imbalance of naïve and memory T cells in peripheral lymphocyte subpopulaions at onset of type 1 diabetes A. Teniente-Serra, E. Pizarro, C.Esteve-Cols, M. Julian, M. Fernández, E. Marínez-Cáceres, Badalona, Spain WS.A3.01.04 Glycolyic T cell metabolism drives faster disease progressionin progressive muliple sclerosis paients S. De Biasi, E. Bianchini, M. Nasi, L. Gibellini, S. Pecorini, D. Lo Tartaro, A. Simone, D. Ferraro, F. Viteta, P. Sola, A. Cossarizza, M. Pini, Modena, Italy WS.A3.01.05 Measurement of serum inliximab levels and detecion of free and bound ani-inliximab anibodies in paients with rheumatoid arthriis. C. Hermanrud, M. Ryner, R. Pullerits, K. Hambardzumyan, N. Vivar Pomiano, P. Marits, I. Gjertsson, S. Saevarsdoir, A. Fogdell-Hahn, Stockholm, Sweden WS.A3.01.06 Imaging low cytometry enhances the detecion of small paricles and rare events enabling emerging applicaions in immunology and oncology P. Rhein, A. Goergens, B. Giebel, S. Groenefeld-Krentz, C. Eckert, Darmstadt, Germany WS.A5.02 Early T cell funcions in immune responses 14:45 - 16:00 G102-103 Chairpersons: Diana Dudziak, Germany & Wilfried Ellmeier, Austria WS.A5.02.01 Mature CD10+and immature CD10-neutrophils present in G-CSF-treated donors display opposite efects on T cells O. Marini, S. Costa, D. Bevilacqua, F. Calzei, N. Tamassia, C. Spina, D. De Sabata, E. Tinazzi, C. Lunardi, M. T. Scupoli, C. Cavallini, E. Zorai, I. Tinazzi, A. Marcheta, A. Vassanelli, M. Canini, G. Gandini, A. Ruzzenente, A. Guglielmi, F. Missale, W. Vermi, C. Tecchio, M. A. Cassatella, P. Scapini, Verona, Italy WS.A5.02.02 Tight translaional control of glycolysis and faty acid metabolism regulates the transiion of CD4+ T cells from quiescence to metabolic remodelling S. Ricciardi, N. Manfrini, R. Alieri, P. Calamita, M. Crosi, R. Muller, M. Pagani, S. Abrignani, S. Bifo, Milan, Italy WS.A5.02.03 Regulatory and convenional T cell transcripion factors are reciprocally controlled during

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Salmonella infecion S. Clay, A. Bravo Blas, D. Wall, M. MacLeod, S. Milling, Glasgow, United Kingdom WS.A5.02.04 CD28 cosimulaion and not TCR controls the efector funcions of acivated CD4 T cells B. Soskic, D. A. Glinos, D. M. Sansom, G. Trynka, Cambridge, United Kingdom WS.A5.02.05 The genome organizer Satb1 is required for the development of TH17 cells through regulaion of IL-2 expression M. Köhne, D. Sommer, J. Schulte-Schrepping, L. Schmidleithner, K. Klee, J. Wißfeld, L. Holsten, K. Händler, M. Geyer, T. Kuhlmann, J. Alferink, C. Wickenhauser, J. L. Schultze, M. Beyer, Bonn, Germany WS.A5.02.06 Unique metabolic requirements for T helper 2 polarizaion by dendriic cells L. Pelgrom, A. Sergushichev, A. J. van der Ham, B. M. Winkel, M. Yazdanbakhsh, M. N. Artyomov, B. Everts, Leiden, Netherlands WS.A5.03 DC and issue-derived cellular responses 16:30 - 17:45 G102-103 Chairpersons: Manfred Lutz, Germany & Chrisiane Ruedl, Singapore WS.A5.03.01 Engulfment and acive shutling of mast cell granules boosts dendriic cell funcions J. Kotrba, J. Dudeck, J. Froebel, A. Dudeck, Magdeburg, Germany WS.A5.03.02 Cross-dressing of mast cells with MHC II from dendriic cells during skin Inlammaion J. Dudeck, A. Medyukhina, J. Froebel, J. Kotrba, M. Figge, A. Dudeck, Magdeburg, Germany WS.A5.03.03 CD86+ anigen-presening B cells are increased in solid cancers and induce tumor anigen-speciic T cell responses K. Wennhold, M. Thelen, A. Lechner, H. Schlößer, M. von Bergwelt-Baildon, Cologne, Germany WS.A5.03.04 Beta2-integrins restrict dendriic cell migratory phenotype through MRTFA/SRF signaling and a Syk-dependent epigeneic mechanism C. Guenther, M. Fusciello, M. Ilander, M. Sokolova, T. Savinko, L. Uoila, S. Yao, M. Moser, S. W. Morris, V. Cerullo, S. Tojkander, M. Variainen, S. C. Fagerholm, Helsinki, Finland WS.A5.03.05 Expanded T-cell clones are present in the synovium before the clinical onset of rheumatoid arthriis G. Balzarei, P. L. Klarenbeek, M. E. Doorenspleet, M. J. de Hair, B. C. van Schaik, R. E. Esveldt, M. G. van de Sande, D. M. Gerlag, A. H. van Kampen, F. Baas, P. Tak, N. de Vries, Amsterdam, Netherlands WS.A5.03.06 Systems metabolic proiling reveals synergisic control of naive T cell priming by autophagy and mTOR N. Franceco, L. Papagno, A. Caputo, V. Appay, Padova, Italy WS.A2.01 T cells in aging 16:30 - 17:45 E102 Chairpersons: Niels Hellings, Belgium & Jacek Witkowski, Poland WS.A2.01.01 Characherisaion of IL 10 producing CD4+ T cells in aged mice I. M. Ogunsulire, M. Almanan, D. Hildeman, C. Hölscher, Sülfeld, Germany WS.A2.01.02 Peripheral Anibody iters are afected by highly difereniated, senescent, and exhausted T cells, and pro-inlammatory changes in the human Bone Marrow E. C. Naismith, L. Pangrazzi, C. Miggitsch, M. Grasse, B. Weinberger, K. Trieb, B. Grubeck- Loebenstein, Innsbruck, Austria WS.A2.01.03 Strong homeostaic TCR signals induce formaion of self-tolerant virtual memory CD8 T cells A. Moudra, A. Drobek, D. Mueller, M. Huranova, V. Horkova, M. Pribikova, R. Ivanek, S. Oberle, D. Zehn, K. D. McCoy, P. Draber, O. Stepanek, Prague, Czech Republic WS.A2.01.04 Extreme memory inlaion of HLACw0702 restricted CMV speciic CD8+ T cells that dominate the CD8+ T cell repertoire during healthy ageing L. Hosie, A. Pachnio, J. Zuo, H. Pearce, S. Riddell, P. Moss, Birmingham, United Kingdom WS.A2.01.05 Age-Related Decline in Primary CD8+ T Cell Responses is Associated with the Development of Senescence in a Subset of Anigenically Naive CD8+ T Cells N. L. La Gruta, K. M. Quinn, A. Fox, K. L. Harland, B. E. Russ, J. Li, T. H. Nguyen, L. Loh, M. Olshansky, H. Naeem, K. Tsyganov, F. Wiede, R. Webster, C. Blyth, X. Y. Sng, T. Tiganis, D. Powell, P. C. Doherty, S. J. Turner, K. Kedzierska, Clayton, Australia WS.A2.01.06 Inluence of aging on calcium signals and cytotoxicity in murine CD8+ T cells

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A. Angenendt, R. Steiner, A. Knörck, G. Schwär, E. Krause, A. Lis, Homburg, Germany Symposia and Workshops Track B S.B1 Tumor vaccinaion principles and immunotherapy 8:30 - 9:45 Elicium Chairpersons: Silke Appel, Norway & Blanka Rihova, Czech Republic S.B1.01 Donor-derived T-cell receptors in cancer immunotherapy Johanna Olweus, Norway S.B1.02 Deiniion of Natural Killer cell heterogeneity in human and mouse by high-throughput single- cell RNA sequencing Eric Vivier, France S.B1.03 Intratumorally produced immunoglobulin repertoires Dmitriy Chudakov, Russia S.B2 Environmental regulaion ani-tumor responses 16:30 - 17:45 Auditorium Chairpersons: Ignacio Melero, Spain & Vito Pistoia, Italy S.B2.01 „Flipping“ over monocytes into immune regulatory cells Vincenzo Bronte, Italy S.B2.02 Splice variant-based immune checkpoints for NK in the cancer microenvironment Angel Porgador, Israel S.B2.03 Dissecing immune complexity of metastaic breast cancer Karin de Visser, The Netherlands BS.B.01 Bright Sparks 10:15 - 11:30 Auditorium Chairpersons: Linde Meyaard, The Netherlands & Djordje Miljkovic, Serbia BS.B.01.01 Immunotargeing of acute myeloid leukemia by highly polyclonal Delta One T cells B. Di Lorenzo, A. E. Simões, F. Caiado, P. Tieppo, D. V. Correia, J. Déchanet-Merville, T. Schumacher, H. Norell, I. Prinz, S. Ravens, D. Vermijlen, B. Silva-Santos, Lisboa, Portugal BS.B.01.02 Broad tumor microenvironment remodelling ater oncolyic Adenovirus coding for TNFa and IL-2 enable T-cell therapies to deliver complete responses in solid tumors V. Cervera-Carrascon, R. Havunen, J. M. Santos, M. Siurala, S. Sorsa, A. Hemminki, Helsinki, Finland BS.B.01.03 NF-kB c-Rel is crucial for the regulatory T cell immune checkpoint in cancer. Y. Grinberg-Bleyer, H. Oh, A. Desrichard, T. Chan, R. Schmid, M. Hayden, U. Klein, S. Ghosh, Lyon, France BS.B.01.04 Mitochondrial DNA shapes metabolism in immune response A. V. Lechuga-Vieco, G. Prota, U. Gileadi, A. Latorre-Pellicer, J. Pellico, J. Ruíz-Cabello, V. Cerundolo, J. A. Enriquez,, Madrid, Spain BS.B.01.05 Milieu Interieur: deining immunological variability through systems biology for a beter understanding of disease D. Dufy, E. Pain, C. Posseme, B. Charbit, J. Bergsted, H. Quach, V. Rouilly, M. Hasan, J. Fellay, J. Di Santo, M. Albert, L. Quintana Murci, Milieu Intérieur Consorium, Paris, France BS.B.01.06 T cell - target cell communicaion is determined by glycosphingolipid-mediated shielding of cell surface proteins A. A. de Waard, M. L. Jongsma, T. Zhang, S. Holst, M. Wuhrer, C. E. van der Schoot, R. M. Spaapen, Amsterdam, Netherlands WS.B3.01 Molecular regulaion of T cell responses 10:15 - 11:30 G106-107 Chairpersons: Günes Esendağlı, Turkey & Robbert Spaapen, The Netherlands WS.B3.01.01 Resident CD4+ T cells in secondary lymphoid organs A. C. Kaminski, O. Pabst, M. Ugur, Aachen, Germany WS.B3.01.02 Producion of extracellular adenosine by CD73+ dendriic cells is crucial for inducion of T cell hyporesponsiveness C. Silva-Vilches, K. Mahnke, Heidelberg, Germany WS.B3.01.03 EGFR-HIF1α signaling posiively regulates the development of Th9 cells S. Roy, Z. Rizvi, A. Awasthi, Faridabad, India WS.B3.01.04 Post-transcripional regulaion of cytokine producion in T cells by RNA binding proteins B. Popovic, F. Şalerno, S. Engels, F. van Alphen, A. Guislain, B. P. Nicolet, M. C. Wolkers,

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Amsterdam, Netherlands WS.B3.01.05 Lysosome-related organelle tethering controls direcionally disinct cytokine transport in T cells B. Qu, Y. Zhou, R. Zhao, E. C. Schwarz, R. Akbar, V. Patu, V. Helms, H. Rieger, Homburg, Germany WS.B3.01.06 Targeing E3 ubiquiin ligase receptor cereblon to simulate Myc-driven metabolismin CD8+ T cells R. Hesterberg, A. A. Akufo, M. S. Beaty, W. E. Goodheart, M. Fernandez, J. L. Cleveland, P. K. Epling-Burnete, Tampa, United States WS.B1.01 Immune checkpoints in ani-tumor therapy 14:45 -16:00 E104-107 Chairpersons: Antoine Carpenier, France & Peter Steinberger, Austria WS.B1.01.01 Impact of tumor heterogeneity on response to immune checkpoint inhibiion S. Sánchez Alonso, G. Sei Jeréz, M. Arroyo Correa, T. Hernandez Paredero, A. Alfranca González, Madrid, Spain WS.B1.01.02 Raional therapeuic modulaion of the tumour microenvironment sensiizes cancers to immune checkpoint blockade R. M. Zemek, E. De Jong, W. L. Chin, V. Fear, C. Forbes, T. Casey, A. R. Forrest, D. O‘Muiri, M. Small, A. Zaitouny, M. J. Millward, A. K. Nowak, T. Lassman, R. A. Lake, A. Bosco, W. J. Lesterhuis, Perth, Australia WS.B1.01.03 Molecular recalibraion of PD-1+ anigen-speciic T cells as immunotherapy for Hepatocellular carcinoma I. Otano, D. Escors, A. Schurich, H. Singh, F. Robertson, B. Davidson, G. Fusai, F. A. Vargas, Z. Tan, J. Aw, N. Hansi, P. Kennedy, S. Xue, H. Stauss, A. Bertolei, A. Pavesi, M. K. Maini, London, United Kingdom WS.B1.01.04 CD47-SIRPa checkpoint blockade involves kindlin3-dependent enhancement of CD11b/CD18- integrin ainity and cytotoxic synapse formaion P. Boui, H. Matlung, M. van Houdt, P. Verkuijlen, K. Franke, T. W. Kuijpers, T. K. van den Berg, Amsterdam, Netherlands WS.B1.01.05 HVEM as a new checkpoint blockade for cancer immunotherapy P. KC, S. Brunel, N. Aubert, D. Olive, G. Marodon, Paris, France WS.B1.01.06 Gastro-intesinal Stromal Tumors show enhanced numbers of checkpoint-negaive CD8 T-cells Y. Klaver, M. Rijnders, A. Oostvogels, R. Wijers, M. Smid, D. Grunhagen, C. Verhoef, S. Sleijfer, C. Lamers, R. Debets, Roterdam, Netherlands WS.B2.02 Tumor immune surveillance and evasion 14:45 - 16:00 G104-105 Chairpersons: Antonio Sica, Italy & Franisek Mrazek, Czech Republic WS.B2.02.01 Tumor immune evasion arises through loss of TNF sensiivity J. Oliaro, C. Kearney, S. Vervoort, R. Johnstone, Melbourne, Australia WS.B2.02.02 IL-33/ST2 signaling promotes the survival and proliferaion of AML1/ETO leukemic stem cells P. Näf, R. Radpour, C. Riether, A. F. Ochsenbein, Bern, Switzerland WS.B2.02.03 Characterizaionof CC-chemokine Receptor 6 (CCR6) and CC-chemokine Ligand 20 (CCL20) mediated immunosurveillance in the iniiaion and progression of malignant melanoma D. Marin-Garcia, A. H. Enk, A. S. Lonsdorf, Heidelberg, Germany WS.B2.02.04 Unraveling the mechanism behind aberrant CD37 expression in human B cell lymphoma S. Elfrink, C. de Winde, M. van den Brand, E. Jansen, F. Doubrava-Simmer, S. van Deventer, C. Hess, W. Stevens, D. van Spronsen, H. van Krieken, C. Figdor, B. Scheijen, A. van Spriel, Nijmegen, Netherlands WS.B2.02.05 A generic, cost-eicient high performance capillary liquid chromatography-high resoluion mass spectrometry method for quality control of pepide pools G. Bosc-Bierne, V. Armuzza, M. G. Weller, O. J. Kreuzer, Berlin, Germany WS.B2.02.06 G-MDSC derived exosomes promote the progression of colon cancer S. Wang, Y. Wang, J. Ma, H. Xu, Zhenjiang, China Symposia and Workshops Track C S.C2 Immune signaling and therapy in autoimmunity 14:45 - 16:00 Elicium Chairpersons: Ed Geissler, Germany & Güher Saruhan-Direskeneli, Turkey

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S.C2.01 Myeloid and glial cells collaborate to regulate neuroinlammaion Trevor Owens, Denmark S.C2.02 Intracellular signaling during autoimmune inlammaion Aila Mocsai, Hungary S.C2.03 How to modulate TCR signalling for pepide therapy in autoimmunity David Wraith, United Kingdom WS.C1.01 Regulaion in issue speciic autoimmunity 1 8:30 - 9:45 G102-103 Chairpersons: Marta Alarcòn-Riquelme, Spain & Mayda Gürsel, Turkey WS.C1.01.01 Human skin-resident and funcionally competent memory T cells survive myeloablaion preceding allogeneic hematopoieic stem cell transplantaion J. Strobl, N. Bayer, M. Mayrdorfer, B. Reininger, L. Hammerl, S. Saluzzo, P. Kalhs, W. Rabitsch, G. Hopinger, G. Stary, Vienna, Austria WS.C1.01.02 Phenotypic, molecular and funcional characterisaion of pro-inlammatory IL-17+ CD8+ T (Tc17) cells in psoriaic arthriis K. J. Steel, U. Srenathan, L. E. Durham, S. Wu, M. L. Ridley, E. Chan, B. W. Kirkham, L. S. Taams, London, United Kingdom WS.C1.01.03 Lymphoid neogenesis in kidneys during lupus: involvement of CXCR3-expressing T cells R. Veber, C. Le Coz, S. Lecomte, F. Monneaux, K. A. Fenton, H. Dumorier, Strasbourg, France WS.C1.01.04 Intracapillary immune complexes recruit and acivate slan-expressing CD16+ monocytes in human lupus nephriis F. Olaru, T. Döbel, A. Lonsdorf, A. Enk, H. Gröne, K. Schäkel, Heidelberg, Germany WS.C1.01.05 Tbet provides advantage to Tregs for homing into type 1 inlammaion sites in vivo B. Akkaya, M. Akkaya, A. H. Holstein, J. Al Souz, M. P. Maz, E. M. Shevach, Bethesda, United States WS.C1.01.06 Nox2 deiciency in CD4+CD25+FoxP3+ T cells limits angiotensin II-induced hypertension and cardiovascular remodelling S. Cellone Trevelin, A. Emerson, H. Mongue-Din, P. D. Becker, C. Oriz, L. A. Smyth, G. Sawyer, A. Iveic, Q. Peng, R. Elgueta, R. I. Lechler, A. M. Shah, G. Lombardi, London, United Kingdom WS.C3.01 Transplantaion - pathogenesis and early diagnosis 8:30 - 9:45 G106-107 Chairpersons: Birgit Sawitzki, Germany & Ilja Striz, Czech Republic WS.C3.01.01 Improved risk straiicaion of pretransplant donor-speciic anibodies with epitope analyses E. G. Kamburova, on behalf of the PROCARE consorium, H. G. Oten, Utrecht, Netherlands WS.C3.01.02 Detecion of alloanibodies against NK cell anigens ater transplantaion T. Langer Jacobus, R. E. Schmidt, C. S. Falk, E. Jäckel, F. W. Vondran, C. Ferreira de Figueiredo, R. Jacobs, Hannover, Germany WS.C3.01.03 HLA Class I Haplotype Diversity Is Consistent with Selecion for Frequent Exising Haplotypes Y. Louzoun, I. Alter, M. Maiers, L. Gragert, Ramat Gan, Israel WS.C3.01.04 High numbers of donor-speciic IL-21 producing cells predict rejecion ater kidney transplantaion N. M. van Besouw, L. Yan, R. de Kuiper, M. Klepper, D. Reijerkerk, D. L. Roelen, F. H. Claas, M. C. Clahsen-van Groningen, D. A. Hesselink, C. C. Baan, Roterdam, Netherlands WS.C3.01.05 Immunizaion against the polysaccharide Poly-N-acetylglucosamine reduces grat-versus-host disease without afecing microbial diversity J. Hülsdünker, O. S. Thomas, Z. Gao, S. Duquesne, S. Kirschnek, A. Schmit-Graef, M. J. Blaser, G. B. Pier, R. Zeiser, Freiburg, Germany WS.C3.01.06 Moifs of pepides binding in HLA-DP and their relaion with T-cell epitope groups relevant in stem cell transplantaion P. Van Balen, M. G. Kester, W. De Klerk, P. Crivello, A. H. De Ru, M. Van de Meent, I. Jedema, M. H. Heemskerk, K. Fleischhauer, J. H. Falkenburg, P. A. Van Veelen, Leiden, Netherlands WS.C4.02 Manipulaion of Tolerance by FoxP3+ T Regs 10:15 - 11:30 E102 Chairpersons: Mübeccel Akdis, Switzerland & Abdel Saoudi, France WS.C4.02.01 IL-21 sustains asthmaic and colitogenic CD4+ T cell efector responses by promoing apoptosis of FoxP3+ regulatory T cells L. Tortola, H. Pawelski, S. S. Sonar, M. Kopf, Zurich, Switzerland WS.C4.02.02 IL-10 signaling in CD11c+ myeloid cells prevents gluten-dependent intraepithelial CD4+ cytotoxic T lymphocyte iniltraion and epithelial damage in the small intesine 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 57 Monday, September 3rd, 2018 ECI2018

L. M. M. Costes, D. J. Lindenbergh-Kortleve, L. A. van Berkel, S. Veenbergen, N. Papazian, Y. Simons-Oosterhuis, J. J. Karrich, R. M. Hoogenboezem, B. E. Clausen, T. Cupedo, J. N. Samsom, Roterdam, Netherlands WS.C4.02.03 An autocrine TNFa - TNFR2 loop promotes epigeneic efects inducing human Treg stability in vitro P. C. Urbano, H. J. Koenen, I. Joosten, X. He, Nijmegen, Netherlands WS.C4.02.04 Interleukin-34 contributes to Tregs suppressive funcion and inhibits allogeneics responses A. Freuchet, S. Bezie, C. Usal, V. Daguin, C. Guillonneau, I. Anegon, Nantes, France WS.C4.02.05 Repairing Foxp3 mutaions in scurfy T cells restores regulatory T cell funcion l. Jeker, M. Kornete, Basel, Switzerland WS.C4.02.06 Epigeneic ediing converts naive and memory CD4+ T cells into FOXP3 expressing regulatory T cells C. Kressler, D. Hamo, G. Gasparoni, J. Walter, A. Hamann, J. K. Polansky, Berlin, Germany WS.C5.01 Physiopathology of allergic disorders 16:30 - 17:45 E104-107 Chairpersons: Francesco Annunziato, Italy & Thomas Marichal, Belgium WS.C5.01.01 FcγRIIA/CD32A-expressing platelets determine the severity of experimental anaphylaxis F. Jönsson, H. Beuier, B. Hechler, O. Godon, Y. Wang, C. M. Gillis, L. de Chaisemarin, A. Gouel- Chéron, S. Magnenat, L. Macdonald, A. Murphy, S. Chollet-Marin, D. Longrois, C. Gachet, P. Bruhns, NASA consorium, Paris, France WS.C5.01.02 Novel role for the acute phase protein serum amyloid A in the iniiaion of type 2 immunity U. Smole, S. Lajoie, N. Gour, X. Xiao, J. Phelan, C. Köhler, N. Yao, L. Caraballo, E. Malle, S. Rosskopf, B. Kratzer, J. Chakir, A. Lane, W. Pickl, M. Wills-Karp, Vienna, Austria WS.C5.01.03 CD300c receptor co-simulates IgE-mediated basophils acivaion and its expression is increased in cow´s milk allergic children O. Zenarruzabeiia Belaustegi, J. Vitallé, I. Terrén, A. Orrania, I. Asigarraga, L. Dopazo, C. González, C. Tutau, L. Santos-Díez, P. Gamboa, A. Bilbao, F. Borrego, Barakaldo, Spain WS.C5.01.04 C5a receptor 1 acivaion on vacuolated eosinophils drives maladapive immunity in experimental allergic asthma A. V. Wiese, K. M. Quell, F. Ender, T. Vollbrandt, P. König, Y. Laumonnier, J. Köhl, Lübeck, Germany WS.C5.01.05 Single cell RNA-Seq ideniies an exquisite pathogenic Th2 cell gene signature and pinpoints cellular metabolism as a major disinguishing factor J. M. Coquet, Solna, Sweden WS.C5.01.06 Notch signaling in CD4+ T cells supports lymph node egress of Th2 cells in allergic airway inlammaion I. Tindemans, A. KleinJan, M. J. de Bruijn, M. Lukkes, A. van den Branden, W. F. van Ijcken, D. Amsen, R. Stadhouders, R. W. Hendriks, Roterdam, Netherlands Symposia and Workshops Track D S.D1 Microbiome, metabolites and the immune system 14:45 - 16:00 Auditorium Chairpersons: Gerd Bouma, The Netherlands & Arno Hänninen, Finlan S.D1.01 Autophagy regulates chronic intesinal inlammaion at several levels Kevin Maloy, United Kingdom S.D1.02 Anibody responses to the intesinal microbiota Oliver Pabst, Germany S.D1.03 Regulaing intesinal immune responses to luminal anigens Janneke Samsom, The Netherlands S.D2 Innate lymphoid cells a topic of debate 16:30 - 17:45 Elicium Chairpersons: Andreas Diefenbach, Germany & Adrian Hayday, United Kingdom S.D2.01 Using super-resoluion microscopy to watch immune cells kill Dan Davis, United Kingdom S.D2.02 Human Innate Lymphoid cells (Pro & Con Session) James di Santo, France & Chiara Romagnani, Germany WS.D4.02 Responses to mucosal microbial pathogens 8:30 - 9:45 G104-105 Chairpersons: Theo Geijtenbeek, The Netherlands & Nadine Reiher, Germany 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 58 Monday, September 3rd, 2018 ECI2018

WS.D4.02.01 Combined chemical geneics and data-driven bioinformaics approach ideniies receptor tyrosine kinase inhibitors as host-directed drugs for intracellular bacterial infecions C. J. Korbee, M. T. Heemskerk, D. Kocev, E. van Strijen, O. Rabiee, K. L. Franken, L. Wilson, N. D. Savage, S. Džeroski, T. H. Otenhof, M. C. Haks, Leiden, Netherlands WS.D4.02.02 Host-directed, autophagy-modulaing compounds restrict intracellular Mycobacterium tuberculosis and Salmonella Typhimurium infecion in human macrophages M. T. Heemskerk, C. J. Korbee, J. Esselink, C. Carvalho dos Santos, F. Vrieling, I. Gordijn, L. Wilson, T. H. Otenhof, M. C. Haks, Leiden, Netherlands WS.D4.02.03 The Mal-IFN-γ receptor axis receptor axis and TIRAP-S180L polymorphism as determinants of suscepibility to pneumococcal disease N. Munoz-Wolf, C. M. Ni Cheallaigh, M. Herrlein, D. Golenbock, K. A. Fitzgerald, L. A. O‘Neill, E. C. Lavelle, Dublin, Ireland WS.D4.02.04 Dual RNA-seq unveils novel host-pathogen interacions during colonic bacterial infecions F. Wan, Balimore, United States WS.D4.02.05 iNOS- AND NOX1- Dependent ROS producion maintains bacterial homeostasis in the ileum of mice A. Kielland, C. Matziouridou, S. Rocha, K. Rudi, O. A. Haabeth, H. Carlsen, Ås, Norway WS.D4.02.06 NLRP11 negaively regulates NF-κB and type I interferon responses K. Ellwanger, E. Becker, I. Kienes, A. Sowa, Y. Postma, Y. Cardona Gloria, A. N. Weber, T. A. Kufer, Stutgart, Germany WS.D3.01 Novel vaccine approches to intracellular pathogens 14:45 - 16:00 G106-107 Chairpersons: Tom Otenhof, The Netherlands & Kingston Mills, Ireland WS.D3.01.01 Targeted delivery of BCG vaccine to the DEC-205 receptor improves protecive eicacy against Mycobacterium tuberculosis C. Counoupas, R. Pinto, L. Baker, G. Ngalingam, A. Nisa, W. Briton, J. Triccas, Sydney, Australia WS.D3.01.02 HLA-E restricted human CD8+ T-cells: a novel human T-cell subset with unique properies which impact vaccinaion strategies against tuberculosis S. A. Joosten, K. E. van Meijgaarden, T. Prezzemolo, A. M. Driij, K. L. Franken, C. K. Dingenouts, P. Ruibal, T. H. Otenhof, Leiden, Netherlands WS.D3.01.03 During experimental tuberculosis, interleukin-27R regulates protecion and limits the expansion of mulifuncional T cells by inhibiing interleukin-17A K. Riter, J. Behrends, A. Hölscher, J. Volz, I. Rosenkrands, H. Erdmann, C. Hölscher, Borstel, Germany WS.D3.01.04 Human Plasmodium falciparum infecion induces a predictable and persistent distorion in transcriptomic landscapes across T cell subsets T. S. Watkins, F. Amante, S. Turner, S. Darko, A. Ransier, D. L. Doolan, D. C. Douek, J. S. McCarthy, J. J. Miles, Cairns, Australia WS.D3.01.05 BCG-induced trained innate immunity during controlled human malaria infecion J. Walk, C. de Bree, W. Graumans, R. Siebelink-Stoter, G. van Gemert, M. van de Vegte-Bolmer, K. Teelen, C. C. Hermsen, R. J. Arts, M. C. Behet, S. J. Moorlag, A. Yang, R. van Crevel, P. Aaby, Q. de Mast, A. J. van der Ven, C. Stabell Benn, M. Netea, R. W. Sauerwein, Nijmegen, Netherlands WS.D3.01.06 Evaluaion of muli-epitope pepides derived from diferent Leishmania proteins as potenial vaccine candidates against human Leishmaniasis S. Hamrouni, K. Aoun, A. Kidar, R. Chamakh Ayari, E. Peitdidier, J. Lemesre, R. Bras Gonçalves, A. Meddeb Garnaoui, Tunis, Belvédère, Tunisia WS.D2.01 Molecular properies of innate immune cells 14:45 - 16:00 E102 Chairpersons: Grace Birch, United Kingdom & Angela Santoni, Italy WS.D2.01.01 Non-apoptoic TRAIL funcion modulates NK cell acivity during viral infecion L. Cardoso Alves, M. D. Berger, N. Kirschke, C. Lauer, N. Corazza, P. Krebs, Bern, Switzerland WS.D2.01.02 Recogniion of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recogniion G. R. Balaji, O. A. Aguilar, Z. Fu, M. Tanaka, J. R. Carlyle, J. Rossjohn, R. Berry, Melbourne, Australia WS.D2.01.03 CD16A acivaion of NK cells primes memory-like cytotoxicity against cancer cells J. Pahl, J. Koch, J. Götz, A. Arnold, U. Reusch, T. Gantke, E. Rajkovic, M. Treder, A. Cerwenka,,

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Mannheim, Germany WS.D2.01.04 Dynamic changes in intrathymic ILC populaions during neonatal development R. Jones, G. Anderson, D. R. Withers, Birmingham, United Kingdom WS.D2.01.05 Innate lymphoid cell reconsituion post lethal irradiaion and bone marrow transplant R. Albugami, R. Alhamawi, C. Dempsey, C. Willis, D. Withers, N. Jones, Birmingham, United Kingdom WS.D2.01.06 Killer cell Immunoglobulin-like receptor 3DL1 polymorphism deines disinct hierarchies of anigen recogniion J. P. Vivian, P. Saunders, P. Pymm, J. Rossjohn, A. Brooks, Clayton, Australia WS.D4.03 Immune sensing of microbial infecions 16:30 - 17:45 G106-107 Chairpersons: Linde Meyaard, The Netherlands & Simon Milling, United Kingdom WS.D4.03.01 Funcional cooperaion between complement factor H and the long pentraxin PTX3 in the immune response to Aspergillus fumigatus R. Parente, F. Petroni, M. Stravalaci, M. Sironi, R. Leone, S. Valenino, A. J. Day, B. Botazzi, A. Mantovani, A. Inforzato, Rozzano, Italy WS.D4.03.02 Orchestraion of systemic ani-fungal Th17 immunity and immune pathology by a single member of the mycobiome P. Bacher, T. Hohnstein, E. Beerbaum, M. Röcker, S. Kaufmann, C. Brandt, J. Röhmel, U. Stervbo, M. Nienen, N. Babel, J. Milleck, M. Assenmacher, O. A. Cornely, G. Heine, M. Worm, P. Creutz, C. Ruwwe-Glösenkamp, L. E. Sander, O. Kniemeyer, A. A. Brakhage, C. Schwarz, A. Schefold, Berlin, Germany WS.D4.03.03 Human blood monocytes from ani-inlammatory vesicles in response to pathogenic Candida albicans L. D. Halder, E. A. Jo, M. F. Gomes, S. Babych, T. Krüger, O. Kniemeyer, B. Jungnickel, P. F. Zipfel, C. Skerka, Jena, Germany WS.D4.03.04 Inherited p40phox deiciency difers from chronic granulomatous disease: Disincive molecular, cellular and clinical phenotypes A. van de Geer, A. Nieto-Patlán, D. Roos, J. Casanova, T. W. Kuijpers, J. Bustamante, Amsterdam, Netherlands WS.D4.03.05 TRIM5α-mediated autophagy: Where HIV-1 restricion and molecular inlammaion meet A. P. Cloherty, J. L. van Hamme, R. Sarrami-Forooshani, N. A. Kootstra, T. B. Geijtenbeek, C. M. S. Ribeiro, Amsterdam, Netherlands WS.D4.03.06 Type I interferon-dependent NETosis supports bioilm formaion and survival of Pseudomonas aeruginosa during lung infecion E. Pylaeva, S. Bordbari, I. Spyra, S. Lang, J. Jablonska, Essen, Germany Workshops Track E WS.E2E3.01 Single cells to populaion dynamics and handling Big Data 10:15 - 11:30 G104-105 Chairpersons: Tapio Lönnberg, Finland & Pärt Peterson, Estonia WS.E2E3.01.01 MHC class II-omics for full understanding of MHC class II anigen presentaion M. L. Jongsma, R. Wijdeven, B. Cabukusta, D. Borras, P. Paul, T. van den Hoorn, J. Neejes, Leiden, Netherlands WS.E2E3.01.02 High ainity T cell receptor generate both acive and memory cytotoxic response during a viral infecion F. Luciani, S. Rizzeto, A. Eltahla, C. Cai, E. Keoshkerian, K. Wing, D. Koppstein, W. Van der Byl, K. Shober, M. Efemberger, R. Bull, A. R. Lloyd, D. Busch, Sydney, Australia WS.E2E3.01.03 A Semi-Unsupervised Mulivariate Algorithm for Mining and proiling High-dimensional Flow Cytometry Data P. C. Marins Urbano, L. Rosaria, W. Alkema, A. Koerber, E. de Jong, F. Hoentjen, I. Joosten, H. J. Koenen, Nijmegen, Netherlands WS.E2E3.01.04 Single cell transcriptomes deine the cellular and molecular landscape of human lungs in asthma F. Vieira Braga, G. Kar, T. Gomes, E. S. Fasouli, P. Strzelecka, K. Polanski, M. Efremova, K. Mahbubani, A. Cvejic, K. Saeb-Parsy, O. A. Carpaij, M. Berg, S. Brouwer, K. Aleck, M. van den Berge, A. van-Oosterhout, M. Nawijn, S. A. Teichmann, Cambridge, United Kingdom 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 60 Monday, September 3rd, 2018 ECI2018

WS.E2E3.01.05 DiSNE visualizaion and assessment of clonal kineics reveals muliple trajectories of dendriic cell development D. Lin, A. Kan, J. Gao, E. Crampin, P. Hodgkin, S. Naik, Melbourne, Australia WS.E2E3.01.06 CD4 T cell transcriptomics reveals novel diagnosic and mechanisic immune signatures of tuberculosis J. G. Burel, C. S. Lindestam Arlehamn, M. Pomaznoy, N. Khaan, G. Seumois, J. A. Greenbaum, D. DeSilva, R. Taplitz, R. H. Gilman, M. Saito, P. Vijayanand, A. Sete, B. Peters, La Jolla, United States WS.E4.01 Cell communicaion and signaling in the immune system 16:30 - 17:45 G104-105 Chairpersons: Riita Lahesmaa, Finland & Ingo Schmitz, Germany WS.E4.01.01 Mechanotransducion as a novel immune checkpoint in NK cell cytotoxicity M. Barda-Saad, A. Ben-Shmuel, O. Matalon, J. Kivelevitz, B. Sabag, N. Joseph, G. Biber, Ramat- Gan, Israel WS.E4.01.02 Combining FACS, High-Resoluion Mass-spectrometry, and Single Cell Sequencing Reveals Interactome Efects of Translaional Control M. D. Stadnisky, R. Halpert, S. Siddiq, J. Spidlen, J. Almarode, M. Velazquez-Palafox, I. Taylor, C. Freier, Ashland, United States WS.E4.01.03 Helper T cell extracellular vesicles couple delivery of efector CD40L to anigen recogniion E. B. Compeer, D. G. Saliba, P. F. Céspedes, Š. Bálint, K. Korobchevskaya, C. Cassioli, M. L. Dusin, Oxford, United Kingdom WS.E4.01.04 Itaconate is an ani-inlammatory metabolite that acivates Nrf2 via alkylaion of KEAP1 D. G. Ryan, Dublin, Ireland WS.E4.01.05 Sugar sweet signalling; Exploraion of dendriic cell lecin receptors and their immune modulatory signalling pathways R. J. E. Li, J. E. Rodriguez-Camejo, J. Lübbers, A. Zaal, C. R. Jimenez, S. R. Piersma, T. V. Pham, R. R. de Goeij- de Haas, S. J. van Vliet, Y. van Kooyk, Amsterdam, Netherlands WS.E4.01.06 DLL4 conveys Notch-dependent signals achieving selecive macrophage polarizaion or death B. Charreau, S. Pagie, A. Pabois, N. Gérard, C. Toquet, P. Hulin, S. Nedellec, Nantes, France Educational Sessions (details p. 40) EDU.02 The Uility of Theories in Immunology 10:15 - 11:30 Forum Chairpersons: Adrian Hayday, United Kingdom & Hans Yssel, France EDU.02.01 The Validaion Theory in Immunology Adrian Hayday, United Kingdom EDU.02.02 The „two-niche“ theory of T cell memory Francesca Di Rosa, Italy EDU.02.03 The Disconinuity Theory of Immunity Eric Vivier, France & Thomas Pradeu, France EDU.02.04 The Equilibrium Model of Immunity Gérard Eberl, France EDU.03 Immunology of extracellular vesicles 13:15 - 14:30 G104-105 Chairpersons: Marca Wauben, The Netherlands & Edit Buzas, Hungary EDU.03.01 Extracellular vesicles in acute and chronic inlammaion Edit Buzas, Hungary EDU.03.02 Isolaion and detecion of extracellular vesicles Rienk Nieuwland, The Netherlands EDU.03.03 Extracellular vesicles in immunity Susanne Gabrielsson, Sweden

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 61 Monday, September 3rd, 2018 ECI2018

Men and Women in Immunology (details p. 41) MWI.01 Men and Women in Immunology 8:30 - 9:45 Forum Chairpersons: Anna Fogdell-Hahn (Sweden), Chrisina Helbig (The Netherlands), Peter Openshaw (United Kingdom) MWI.01.01 Opening & Introducion Anna Fogdell-Hahn, Sweden MWI.01.02 News about career challenges for immunologists: examples from UK Peter Openshaw, United Kingdom MWI.01.03 Athena SWAN: does the program work for women, men or both? Catherine Williamson, United Kingdom MWI.01.04 Gender and power: focus on problemaic masculinity as privileges Jesper Fundberg, Sweden MWI.01.05 General Discussion

Joint Symposia (see also p. 35) JS.01 Trends in Vaccinology (IUIS) 13:15-14:30 Elicium Chairpersons: Alberto Mantovani, Italy & Ursula Wiedermann, Austria JS.01.01 Systems Vaccinology: New chances for vaccines against communicable and non-communicable diseases Bali Pulendran, United States of America JS.01.02 Novel vaccines against old foes: Dengue, Zika, Ebola & Co Franz X. Heinz, Austria JS.02.03 New generaion of adjuvants: each target group its own adjuvant? Ed Lavelle, Ireland Prize for Excellence in Vaccines Research and Development in Europe: announcement of the winner 2018 and ceremony (sponsored by Vaccines Europe). JS.02 Systems Immunology for straifying paients with autoimmune diseases (EULAR) 13:15 - 14:30 Auditorium Chairpersons: Riita Lahesmaa, Finland & Timothy R.D. Radstake, The Netherlands JS.02.01 Molecular reclassiicaion of Immune mediated inlammatory condiions as the road to personalised medicine Timothy R.D. Radstake, The Netherlands JS.02.02 Forgoten anibodies of the gut mucosa: IgM and IgA2 Andrea Cerui, Spain JS.02.03 The Straiicaion of Lupus Martha Alarcon-Riquelme, Spain JS.03 Anigen Presentaion in Health and Disease (AAI) 13:15 - 14:30 Forum Chairpersons: Nilabh Shastri, United States of America & Anne Spurkland, Norway JS.03.01 Lymph: composiion, circulaion and immunological role Laura Santambrogio, United States of America JS.03.02 Anigen processing and presentaion in cancer immunosurveillance Robert Binder, United States of America JS.03.03 Generaing pepide-MHC ligands for immune surveillance of foreign and self Nilabh Shastri, United States of America JS.04 HLA in Transplantaion and Autoimmunity (EFI) 13:15 - 14:30 E104-107 Chairpersons: Elissaveta Naumova, Bulgaria & Mieke Boots, The Netherlands JS.04.01 HLA and Solid Organ Transplantaion Frans Claas, The Netherlands JS.04.02 HLA in Haematopoieic Stem Cell Transplantaion Katharina Fleischhauer, Germany JS.04.03 HLA in Autoimmune Diseases Ludvig Sollid, Norway

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 62 Monday, September 3rd, 2018 ECI2018

JS.05 Combinatorial approaches to develop targeted immunotherapeuics (RUS- GEO) 13:15 - 14:30 E102 Chairpersons: Revaz Sepiashvili, Russia & Yvete van Kooyk, The Netherlands JS.05.01 Screening technologies for drug development. Alexander Gabibov, Russia JS.05.02 The hallmark of smart agents: Immunotargeing & controlled release Sergey Deyev, Russia JS.05.03 Novel insights into membrane targeing of B cell lymphoma: lessons learned from tetraspanins Annemiek van Spriel, Netherlands Acteria Alumni Session BA.06 Acteria Alumni Session 14:45 - 16:00 G109 Chairpersons: Chris Schiering, United Kingdom & Thomas Marichal, Belgium BA.06.01 Targeing IgE in allergic diseases Alexander Eggel, Switzerland BA.06.02 Neutrophil heterogeneity and funcion in allergic asthma Thomas Marichal, Belgium BA.06.03 Feedback control of AHR signalling regulates intesinal immunity Chris Schiering, United Kingdom EFIS Award Ceremony (see also p. 12) AC.01 ACTERIA Prizes awarded by EFIS and Ita Askonas Awards Ceremony 10:15 - 11:30 E104-107 Chairpersons: Anne Hosmalin, France & Catherine Sautès-Fridman, France & Lorenzo Moreta, Italy Ita Askonas Award Laureates AC.01.01 The recycled self-autophagy in the immune system (Ita Askonas Award Laureate) Katja Simon, United Kingdom AC.01.02 The discovery and characterizaion of human ILC2. What have we learned during the irst decade?(Ita Askonas Award Laureate) Jenny Mjösberg, Sweden ACTERIA Prizes awarded by EFIS Laureates AC.01.03 Tissue-speciic factors in lung immunity Samuel Philip Nobs, Israel - Doctoral Prize in Allergology AC.01.04 The deconvoluion of cancer related inlammaion: ideniicaion of new players in the tumour microenvironment Eduardo Bonavita, United Kingdom - Doctoral Prize in Immunology AC.01.05 Deconstrucing the human immune system Muzlifah Hanifa, United Kingdom - Early Career Research Prize in Allergology AC.01.06 Intracellular DNA sensing in health and disease Andrea Ablasser, Switzerland - Early Career Research Prize in Immunology

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 63 Monday, September 3rd, 2018 ECI2018 Poster Sessions, Monday, September 3rd, 2018 Track A – Immune development and differentiation P.A1.01 Myeloid lineage speciicaion - Part 1 P.A2.01 Immune development and aging from the cradle to the grave - Part 1 P.A3.01 Immunomonitoring and biomarkers - Part 1 P.A3.02 Immunomonitoring and biomarkers - Part 2 P.A4.01 Germinal centers and B cell difereniaion - Part 1 P.A5.01 Iniiaion of immune responses - Part 1 P.A5.02 Iniiaion of immune responses - Part 2 P.A6.01 Lessons learned from the geneic defects - Part 1 Track B – Tumor immunology and therapy P.B1.01 Tumor vaccinaion principles and Immunotherapy - Part 1 P.B1.02 Tumor vaccinaion principles and Immunotherapy - Part 2 P.B1.03 Tumor vaccinaion principles and Immunotherapy - Part 3 P.B2.01 Environmental regulaion ani-tumor responses - Part 1 P.B2.02 Environmental regulaion ani-tumor responses - Part 2 P.B3.01 T-cell regulaion - Part 1 P.B3.02 T-cell regulaion - Part 2 P.B4.01 T-cell acivaion and exhausion - Part 1 Track C – Autoimmunity, Allergy and Transplantation P.C1.01 Maintenance and local regulaion of issue speciic immunity - Part 1 P.C1.02 Maintenance and local regulaion of issue speciic immunity - Part 2 P.C1.03 Maintenance and local regulaion of issue speciic immunity - Part 3 P.C2.01 Immune signaling and therapy in autoimmunity - Part 1 P.C2.02 Immune signaling and therapy in autoimmunity - Part 2 P.C2.03 Immune signaling and therapy in autoimmunity - Part 3 P.C3.01 Bone Marrow Transplantaion P.C4.01 Manipulaion of tolerance - Part 1 P.C5.01 Allergy, asthma and therapy - Part 1 P.C5.04 Allergy, asthma and therapy - Part 4 P.C6.01 Innate control of inlammaion and issue repair - Part 1 P.C6.02 Innate control of inlammaion and issue repair - Part 2 Track D – Infections and microbial immune regulation P.D1.01 Microbiome, metabolites and the immune system - Part 1 P.D1.02 Microbiome, metabolites and the immune system - Part 2 P.D3.01 Novel approaches to vaccinology - Part 1 P.D3.02 Novel approaches to vaccinology - Part 2 P.D4.01 Exploiing host pathogen interacion - Part 1 P.D4.02 Exploiing host pathogen interacion - Part 2 P.D4.03 Exploiing host pathogen interacion - Part 3 Track E – Technical advances and big data P.E1.01 Visualizing immune responses - Part 1 P.E2.01 How to handle big data?

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 64 Tuesday, September 4th, 2018 ECI2018 Oral Sessions, Tuesday, September 4th, 2018 Keynote Lectures (details p. 44) KL.05 Keynote Lecture 05 12:00 - 12:45 Elicium Chairpersons: Winfried Pickl, Austria & Rene Toes, The Netherlands KL.05 Regulatory T cell homeostasis Adrian Liston, Belgium KL.06 Keynote Lecture 06 12:00 - 12:45 Auditorium Chairpersons: Janneke Samsom, The Netherlands & Ulrich Steinhof, Germany KL.06 T cell metabolism Erika Pearce, Germany Late Breaking Hot Topics HT.05 Late Breaking Hot Topic 05 11:45 - 12:00 Elicium Chairpersons: Winfried Pickl, Austria & Rene Toes, The Netherlands HT.05.01 Quanitaive shotgun proteo-/transcriptomics shows how human regulatory T cells protect their idenity D. Amsen, Amsterdam, The Netherlands HT.06 Late Breaking Hot Topic 06 11:45 - 12:00 Auditorium Chairpersons: Janneke Samsom, The Netherlands & Ulrich Steinhof, Germany HT.06.01 A cauionary note for using pharmacological inhibitors challenges the role of long-chain faty acid oxidaion on immune cells L. Berod, B. Raud, D. G. Roy, A. S. Divakaruni, T. N. Tarasenko, R. Franke, M. Brönstrup, A. N. Murphy, P. J. McGuire, R. G. Jones, T. Sparwasser, Hannover, Germany Symposia and Workshops Track A S.A4 Germinal centers and B cell difereniaion 8:30 -9:45 Auditorium Chairpersons: Marieke van Ham, The Netherlands & Jürgen Wienands, Germany S.A4.01 Germinal centers under the lens: Difereniaion of plasma cells and memory B cells from germinal center precursors Robert Brink, Australia S.A4.02 Microenvironment in B-cell lymphomas: friend or foe? Karin Tarte, France S.A4.03 IgG4 Theo Rispens, The Netherlands S.A5 Iniiaion of Immune response 14:45 -16:00 Elicium Chairpersons: Anna Erdei, Hungary & Alexandra Tsirogianni, Greece S.A5.01 Regulaion of cytotoxic responses Greta Guarda, Switzerland S.A5.02 Dendriic cells in HIV-1 sensing and restricion Theo Geijtenbeek, The Netherlands S.A5.03 The role of Complement in Tolerance Marina Boto, United Kingdom S.A6 Lessons learned from geneic defects 16:30 -17:45 Forum Chairpersons: Günnur Deniz, Turkey & Hilary Longhurst, United Kingdom S.A6.01 Early onset protein losing enteropathy and thrombosis in inherited CD55 deiciency Ahmet Ozen, Turkey S.A6.02 Primary immunodeiciencies Anne Puel, France S.A6.03 Novel Monogenic Causes of Immune Dysregulaion Kaan Boztug, Austria

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 65 Tuesday, September 4th, 2018 ECI2018

WS.A3.02 Biomarkers of adapive immunity 10:15 - 11:30 Forum Chairpersons: Irma Joosten, The Netherlands & Karl Skriner, Germany WS.A3.02.01 Rapid ideniicaion and isolaion of funcional anigen-speciic CD8+ T cells by staining of acivated integrins S. Dimitrov, C. Goutefangeas, L. Besedovsky, A. T. Jensen, A. Chandrand, E. Rusch, R. Businger, M. Schindler, T. Lange, J. Born, H. Rammensee, Tübingen, Germany WS.A3.02.02 Epigeneic signatures of human T helper cell subsets A. Ntalli, S. Kumar, L. Maggi, F. Annunziato, C. Zinser, M. Beckstete, L. Graca, S. Floess, J. Huehn, Braunschweig, Germany WS.A3.02.03 The cold shock protein YB-1 (Y-box binding protein 1) promotes survival of CD4+ T-lymphocytes S. Meltendorf, S. Gieseler-Halbach, J. Handschuh, M. Pierau, A. Arra, P. R. Mertens, U. Thomas, M. C. Brunner-Weinzierl, Magdeburg, Germany WS.A3.02.04 Tissue resident memory T cells as a progressive mulifocal leukoencephalopathy quick biomarker A. Tejeda Velarde, E. Rodríguez Marín, L. Costa-Frossard, Y. Aladro, S. Sainz de la Maza, S. Medina, N. Villarrubia, E. Monreal, E. Roldán, J. Álvarez-Cermeño, L. Villar, Madrid, Spain WS.A3.02.05 T3SS components as the biomarkers of humoral immune response elicited by live bacterial vaccine in humans V. A. Feodorova, A. M. Lyapina, M. A. Khizhnyakova, S. S. Zaitsev, L. V. Sayapina, M. V. Telepnev, O. V. Ulianova, E. P. Lyapina, S. S. Ulyanov, V. L. Moin, Saratov, Russian Federaion WS.A3.02.06 Skin-homing human CD8+ T cells preferenially express GPI-anchored pepidase inhibitor 16 (PI16), an inhibitor of cathepsin K N. Lupsa, B. Érsek, A. Bencsik, A. Horváth, E. Lajkó, Á. Oszvald, Z. Wiener, P. Reményi, G. Mikala, T. Masszi, E. Buzás, Z. Pós, Budapest, Hungary WS.A2.02 Immune development and neonatal responses 10:15 - 11:30 E102 Chairpersons: Vera Marins, Germany & Jürgen Schwarze, United Kingdom WS.A2.02.01 Dynamic transcriptome-proteome correlaion networks contribute to human myeloid difereniaion and neutrophil development A. J. Hoogendijk, M. van den Biggelaar, F. Pourfarzad, C. Aarts, A. Tool, I. Hiemstra, F. van Alphen, C. van der Zwaan, T. K. van den Berg, L. Grassi, M. Fronini, W. H. Ouwehand, A. B. Meijer, T. W. Kuijpers, Amsterdam, Netherlands WS.A2.02.02 CircRNA expression is a highly regulated process during hematopoiesis and lymphocyte difereniaion B. P. Nicolet, S. Engels, F. Aglialoro, E. van den Akker, M. von der Lindern, M. C. Wolkers, Amsterdam, Netherlands WS.A2.02.03 IL-2-vs. IL-15-dependent intrathymic development of regulatory T lymphocytes C. Apert, N. McJannet, P. Romagnoli, J. van Meerwijk, Toulouse, France WS.A2.02.04 Recent thymic emigrants in neonates and adults share an animicrobial molecular signature M. L. Pekalski, A. Rubio Garcia, A. Paterou, R. C. Ferreira, D. B. Rainbow, A. J. Cutler, J. L. Jones, J. A. Todd, L. S. Wicker, Oxford, United Kingdom WS.A2.02.05 Characterising the maturaion of T cell polarisaion in preterm and term infants and in the neonatal chronic lung disease bronchopulmonary dysplasia J. C. Lao, M. A. Pang, A. Malhotra, K. Tan, F. Beker, K. Konig, C. Collins, C. Theda, O. Kamlin, P. J. Berger, A. Veldman, C. A. Nold-Petry, M. F. Nold, Clayton, Australia WS.A2.02.06 CD4+ T cells from human neonates and infants respond extensive against anigens of Candida albicans and Aspergillus fumigatus K. Vogel, M. Pierau, A. Arra, K. Lampe, D. Schlueter, C. Arens, M. C. Brunner-Weinzierl, Magdeburg, Germany WS.A3.03 Immune markers in malignancies 14:45 - 16:00 G102-103 Chairpersons: Chrysoula Nikalaou, Greece & Paul Moss, United Kingdom WS.A3.03.01 NSCLC paients not responding to nivolumab show lowered frequency of co-simulatory receptor-deicient CD8 T cells A. Kunert, E. A. Basak, D. P. Hurkmans, Y. Klaver, M. van Brakel, A. Oostvogels, C. H. Lamers, S. Bins, S. L. Koolen, A. A. van der Veldt, S. Sleijfer, R. H. Mathijssen, J. G. Aerts, R. Debets, Roterdam, Netherlands

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WS.A3.03.02 Circulaing CD4 senescent T cells straify clinical responses to PD-L1/PD-1 immune checkpoint inhibitors in NSCLC M. Zuazo, H. Arasanz, M. Gato, G. Fernández, R. Vera, G. Kochan, D. Escors,, Pamplona, Spain WS.A3.03.03 CD103 tumor Iniltraing lymphocytes as a prognosic factor in colon cancer paients S. M. Talhouni, J. Ramage, Noingham, United Kingdom WS.A3.03.04 Filgrasim enhances T-cell clearance by ani-thymocyte globulin exposure ater unrelated cord blood transplantaion C. de Koning, J. A. Gabelich, J. Langenhorst, R. Admiraal, J. Kuball, J. J. Boelens, S. Nierkens, Utrecht, Netherlands WS.A3.03.05 Next-generaion anigen receptor sequencing of paired diagnosis and relapse samples of B-cell acute lymphoblasic leukemia: an algorithm for Minimal Residual Disease target selecion P. Theunissen, M. de Bie, D. van Zessen, V. de Haas, A. P. Stubbs, V. H. J. van der Velden, Roterdam, Netherlands WS.A3.03.06 Plasma-derived exosomes in head and neck squamous cell carcinoma paients as potenial biomarkers of response to immune therapies M. Theodoraki, T. Hofmann, R. Ferris, T. Whiteside, Ulm, Germany WS.A4.02 Regulaion of B cell development and difereniaion 14:45 - 16:00 G104-105 Chairpersons: Nicolas Fazilleau, France & Karin Tarte, France WS.A4.02.01 B cell posiive selecion is developmentally regulated during ontogeny by the heterochronic protein Lin28b S. Vanhee, S. Data, T. Krisiansen, H. Åkerstrand, S. Lang, S. Vergani, A. Doyle, K. Olsson, S. Soneji, E. Jaensson Gyllenbäck, J. Yuan, Lund, Sweden WS.A4.02.02 The bHLH transcripion factor TCFL5 and its soform CHA diferently modulate c-MYC- dependent B cell proliferaion I. Sánchez-Gómez, J. Galán-Marinez, M. Maza, K. Stamatakis, N. Gironès, M. Fresno, Madrid, Spain WS.A4.02.03 PI3Kδ hyper-acivaion in B cells promote increased suscepibility to S. pneumoniae airway infecion through an anibody independent mechanism. A. Stark, A. Chandra, R. Alam, K. Okkenhaug, Cambridge, United Kingdom WS.A4.02.04 Expansion of acivated CXCR5+ICOS+Th cells and plasmablasts induced by seasonal inluenza vaccine is impaired in ani-IL-6R treated rheumatoid arthriis paients A. Agua-Doce, V. Romao, J. Polido-Pereira, R. Barros, I. P. Lopes, M. I. Seixas, M. J. Saavedra, E. Sacadura-Leite, H. Rebelo-de-Andrade, J. E. Fonseca, L. Graca, Lisboa, Portugal WS.A4.02.05 Funcions of ZBTB24 in human and murine B cells C. Zhu, Y. Zhao, J. Liang, X. Gao, J. Wang, Suzhou, China WS.A4.02.06 Stem cell based gene therapy for Recombinase deicient-SCID F. J. T. Staal, K. Pike-Overzet, Leiden, Netherlands WS.A2.03 Immune cell aging and difereniaion 14:45 - 16:00 E102 Chairpersons: Andreas Meryk, Austria & Cécile van Els, The Netherlands WS.A2.03.01 Ideniicaion of age-related immune signatures by mass cytometry J. Braun, S. Schlickeiser, A. Andrzejewska, F. Papatzika, B. Kruse, S. Geissler, A. Arampatzis, A. Thiel, Berlin, Germany WS.A2.03.02 Aging afects the frequency, funcions and anibody repertoire of human B-1 cells A. M. Hernández-Vázquez, N. Rodríguez-Zhurbenko, T. Quach, T. J. Jopkings, T. L. Rothstein, Havana, Cuba WS.A2.03.03 T cell immunity does not age in a long-lived rodent species M. Izraelson, T. Nakonechnaya, A. Davydov, M. Dronina, D. Miskevich, I. Mamedov, L. Barbashova, M. Shugay, D. Boloin, D. Staroverov, E. Kondratyuk, S. Lukyanov, I. Shams, O. Britanova, D. Chudakov, Moscow, Russian Federaion WS.A2.03.04 Anigen-speciic immunity is inhibited in the skin of older people by p38 MAPK-driven inlammatory monocytes. E. S. Chambers, M. Vukmanovic-Stejic, H. Trahair, A. Appios, V. Birault, M. Noursadeghi, N. Mabbot, M. Rusin, A. Akbar, London, United Kingdom WS.A2.03.05 Screen of epigeneic inhibitors reveals two novel T helper 17 (Th17) cell regulators: BRPF1 and BRPF2

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 67 Tuesday, September 4th, 2018 ECI2018

L. Chen, N. Zaarour, T. Sekine, M. Sundstrom, M. Feldmann, A. Cribbs, F. McCann, P. Bowness, Oxford, United Kingdom WS.A2.03.06 Difereniaion of human Langerhans cells from monocytes and their speciic funcion in inducing IL-22-speciic T helper cells Y. Otsuka, E. Watanabe, E. Shinya, H. Saeki, T. B. Geijtenbeek, H. Takahashi, Tokyo, Japan Sympoisa and Workshops Track B S.B3 The Yin and Yang of T cell regulaion 8:30 - 9:45 Elicium Chairpersons: Friederike Berberich-Siebelt, Germany & Hans Yssel, France S.B3.01 Anigen-speciic regulatory T cells in human immunity Alexander Schefold, Germany S.B3.02 How help for the CTL response generates robust anitumor immunity Jannie Borst, The Netherlands S.B3.03 Maintaining T cell tolerance via the CTLA-4 pathway Lucy Walker, United Kingdom WS.B2.03 Innate ani-tumor immunity 8:30 - 9:45 G104-105 Chairpersons: Vanda Juranic Lisnic, Croaia & Holger Heine, Germany WS.B2.03.01 The macrophage tetraspan MS4A4A interacts with Decin-1 and is required for macrophage- NK cell cross-talk and resistance to metastasis I. Maiola, F. Tomay, M. De Pizzol, B. Savino, T. Gulic, R. Silva-Gomes, R. Carriero, D. Morone, I. N. Shalova, Y. Lee, S. K. Biswas, G. Mantovani, M. Sironi, B. Botazzi, A. Mantovani, M. Locai, Berlin, Germany WS.B2.03.02 Heparanase is required for dendriic cell-natural killer cell crosstalk and subsequent natural killer cell acivaion A. Mayfosh, N. Baschuk, Melbourne, Australia WS.B2.03.03 CD137 (4-1BB) cosimulaion counteracts TGF-β1 inhibiion of anibody-dependent NK cell responses against HER2+ transformed cells M. Cabo, R. Lozano-Rodríguez, M. Ataya, M. Costa-Garcia, S. Santana, M. C. Ochoa, P. Berraondo, I. Melero, M. López-Botet, A. Muntasell, Barcelona, Spain WS.B2.03.04 B7H6, a ligand for NKp30, is regulated by BRD4 in acute myeloid leukemia cells A. Baragaño Raneros, P. Díaz Bulnes, R. M. Rodriguez, B. Suárez Álvarez, C. López Larrea, Oviedo, Spain WS.B2.03.05 Ideniicaion and funcional properies of mature and immature neutrophils in homeostasis, inlammaion and cancer J. B. G. Mackey, R. Jackstadt, T. Jamieson, A. McFarlane, X. L. Rafo, D. Patel, J. Secklehner, J. Vuononvirta, R. Snelgrove, J. Morton, J. Norman, O. J. Sansom, L. M. Carlin, London, United Kingdom WS.B2.03.06 Epithelial damage and issue γδ T cells promote a unique tumour-protecive IgE response G. Crawford, R. Castro Seoane, S. Ward, M. Hayes, M. Hanifa, D. Dunn-Walters, J. Strid, London, United Kingdom WS.B1.02 Novel targets in ani-cancer immune therapy 10:15 - 11:30 E104-107 Chairpersons: Tolga Sütlü, Turkey & Marie-Nicole Theodoraki, Germany WS.B1.02.01 BAFF-R as a novel therapeuic target for Acute Lymphoblasic Leukemia R. Parameswaran, Y. Vicioso, Cleveland, United States WS.B1.02.02 Invesigaion of novel immunotherapeuic targets for colorectal cancer D. Shinko, H. McGuire, T. Ashhurst, S. Clarke, S. Byrne, K. Charles, Sydney, Australia WS.B1.02.03 IL-1R8 is a novel checkpoint regulaing ani-tumor and ani-viral acivity of NK cells M. Molgora, E. Bonavita, A. Ponzeta, F. Riva, M. Barbagallo, S. Jaillon, B. Popovic, G. Bernardini, E. Magrini, F. Gianni, S. Zelenay, S. Jonjic, A. Santoni, C. Garlanda, A. Mantovani, Pieve Emanuele, Italy WS.B1.02.04 Glycan modiied vesicles as a targeted and personalized vaccinaion strategy for the inducion of ani-tumor immunity S. K. Horrevorts, D. A. Stolk, S. J. van Vliet, T. D. de Gruijl, A. A. van de Loosdrecht, Y. van Kooyk, Amsterdam, Netherlands WS.B1.02.05 Heme as a modulator of the therapeuic eicacy of an ani-cancer anibody

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A. Tavares-Kanyavuz, A. Marey-Jarossay, S. Lacroix-Desmazes, J. Dimitrov, Paris, France WS.B1.02.06 Evaluaion of a New Ani-Galecin 9 Immunotherapy Strategy in Pancreaic Cancers A. Quilbe, R. Mustapha, S. Renaud, B. Duchêne, C. De Schuter, G. Herlin, O. Moralès, I. Van Seuningen, N. Jonckheere, N. Delhem, Lille Cedex, France WS.B1.03 Geneically engineered TCR for immunotherapy 14:45 - 16:00 E104-107 Chairpersons: Marieke Griioen, The Netherlands & Anne Pesenacker, Canada WS.B1.03.01 Development and characterizaion of novel ani-GD2 target modules for retargeing of Universal CAR T cells toward GD2 expressing tumors N. Mitwasi, A. Feldmann, R. Bergmann, N. Berndt, C. Rössig, M. Bachmann, Dresden, Germany WS.B1.03.02 Funcional comparison of CARs targeing CD20 with a TCR directed against a CD20 derived pepide T. L. A. Wachsmann, L. Jahn, E. van Diest, J. Leusen, J. Kuball, J. Falkenburg, M. Heemskerk, Leiden, Netherlands WS.B1.03.03 Impaired Early Downstream Signaling Blunts Anigen Sensiivity of CAR-T-cells V. Gudipai, J. Rydzek, I. Perez, S. Königsberger, H. Stockinger, M. Hudecek, J. Huppa, Vienna, Austria WS.B1.03.04 Anitumor acivity by TEGs: alpha/beta T cells engineered to express a deined gamma/delta TCR in a 3D bone marrow niche model of muliple myeloma T. Straetemans, M. Braham, T. Aarts-Riemens, J. Alblas, M. Minnema, Z. Sebestyen, J. Kuball, Utrecht, Netherlands WS.B1.03.05 Engineering anigen-speciic Natural Killer cells against the melanoma-associated anigen tyrosinase via TCR gene transfer A. Parlar, C. Pamukcu, E. C. Sayitoglu, A. Georgoudaki, D. Ozkazanc, M. Aras, M. Chrobok, P. Zahedimaram, L. Ikromzoda, E. Alici, B. Erman, A. D. Duru, T. Sutlu, Istanbul, Turkey WS.B1.03.06 TCR replacement in the endogenous locus via non-viral CRISPR-Cas9-mediated knock-in K. Schober, T. Müller, D. H. Busch, München, Germany WS.B4.01 Molecular control of T cell acivaion and exhausion 16:30 - 17:45 E104-107 Chairpersons: Derk Amsen, The Netherlands & Arzu Aral, Turkey WS.B4.01.01 PTPN22-deicient CD8 T cells resist TGFb suppression and mediate improved ani-tumour responses R. J. Brownlie, C. Garcia, M. Ravasz, D. Zehn, R. Zamoyska, R. J. Salmond, Leeds, United Kingdom WS.B4.01.02 Heterochromain silencing of stemness during CD8+ T cell fate commitment l. Pace, C. Goudot, E. Zueva, P. Gueguen, N. Burgdorf, J. Waterfall, J. Quivy, G. Almouzni, S. Amigorena, Turin, Italy WS.B4.01.03 TLR9 signaling mediates funcional responses induced by direct ligaion of ODN 2216 in CD4+CD25- efector T cells R. K. Sharma, J. Sharma, P. Jain, A. Gupta, N. Sachdeva, Chandigarh, India WS.B4.01.04 The T cell genome in 3D: how higher order chromain structures regulate virus-speciic T cell difereniaion B. E. Russ, M. Olshansky, Z. He, J. Paulsen, S. Tomei, J. Li, P. Collas, C. Murre, S. J. Turner, Clayton, Australia WS.B4.01.05 Deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor- speciic immune landscapes N. L. de Vries, V. van Unen, T. R. Abdelaal, M. E. van Herk, R. van der Breggen, A. Farina Sarasqueta, K. C. Peeters, T. Höllt, B. P. Lelieveldt, F. Koning, N. F. de Miranda, Leiden, Netherlands WS.B4.01.06 ATTACK, a novel bispeciic T cell-recruiing anibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy S. Harwood, S. Lykkemark, A. Ana Alvarez-Cienfuegos, N. Natalia Nuñez-Prado, M. Compte, S. Hernandez-Perez, N. Merino, J. Bonet, R. Navarro, P. M. van Bergen en Henegouwen, K. Mikkelsen, K. Mølgaard, F. Jabs, L. Sanz, F. J. Blanco, P. Roda-Navarro, L. Alvarez-Vallina, Aarhus, Denmark WS.B1.04 Anigen speciicity in ani-tumor immunity 16:30 - 17:45 G106-107 Chairpersons: Tanja de Gruijl, The Netherlands & Andrey Tchorbanov, Bulgaria WS.B1.04.01 Towards the next generaion CAR T cells with TEGs: in vivo eicacy - toxicity proile in 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 69 Tuesday, September 4th, 2018 ECI2018

xenograts of primary human AML disease and healthy bone marrow I. Johanna, T. Straetemans, S. Heijhuurs, T. Aarts-Riemens, H. Norell, L. Bongiovanni, A. de Bruin, Z. Sebestyen, J. Kuball, Utrecht, The Netherlands WS.B1.04.02 Harnessing Pre-Exising Aniviral Immunity to Treat Solid Tumors N. Cuburu, R. Kim, S. M. Pontejo, C. D. Thompson, D. R. Lowy, J. T. Schiller, Bethesda, United States WS.B1.04.03 Ephemeral immune control of cytomegalovirus infecion by T-cells recognizing a single viral epitope F. Mbui, L. Borkner, Z. Chaudhry, L. Cicin-Sain, Braunschweig, Germany WS.B1.04.04 Autologous neo-anigen-speciic T cell responses in low mutaion burden colorectal cancers J. van den Bulk, D. Ruano, M. Visser, M. IJsselsteijn, R. van der Breggen, K. Peeters, S. van der Burg, E. Verdegaal, N. de Miranda, Leiden, Netherlands WS.B1.04.05 A minority of tumor associated anigen speciic T-cells restricted to self-HLA alleles is of suicient avidity to recognize overexpressed endogenously processed anigen M. Roex, L. Hageman, E. van Egmond, S. Veld, C. Hoogstraten, L. Germeroth, F. Falkenburg, I. Jedema, Leiden, Netherlands WS.B1.04.06 Cross-reacive CD8+ T cell receptor clonotypes elicited by inluenza epitope variants are drawn from a narrow repertoire disinct from non-cross-reacive receptors P. G. Thomas, P. Dash, P. Bradley, A. Williams, S. Duan, Memphis, United States Symposia and Workshops Track C S.C3 Transplantaion 14:45 - 16:00 Forum Chairpersons: David Wraith, United Kingdom & Oliver Pabst, Germany S.C3.01 Treaing autoimmune diseases with T regulatory cells – irst clinical data Piotr Trzonkowski, Poland S.C3.02 Innate lymphoid cells and microbioma in GvHD Mete Hazenberg, The Netherlands S.C3.03 Transplantaion, T cell engineering Chiara Bonini, Italy S.C4 Manipulaion of Tolerance 16:30 - 17:45 Auditorium Chairpersons: Anja ten Brinke, The Netherlands & Anna Sediva, Czech Republic S.C4.01 Engineered Dendriic Cells to re-establish Anigen-Speciic Tolerance in T-cell Mediated Diseases Silvia Gregori, Italy S.C4.02 The role of cell metabolism in Treg biology and funcion Benoit Salomon, France S.C4.03 Tolerogenic dendriic cells as a therapeuic strategy to induce tolerance in muliple sclerosis Eva Marínez Caceres, Spain BS.C.01 Bright Sparks Workshop 10:15 - 11:30 Elicium Chairpersons: Edit Buzàs, Hungary & Luis Graca, Portugal BS.C.01.01 Tissue resident memory T-cell (TRM) maintenance is regulated by issue damage R. Stark, T. H. Wesselink, F. M. Behr, N. A. Kragten, K. P. van Gisbergen, R. A. van Lier, Amsterdam, Netherlands BS.C.01.02 TLR7 escapes X chromosome inacivaion in immune cells J. Guéry, Toulouse, France BS.C.01.03 Human regulatory T cells suppress CD4+ T cells by rapidly altering the phosphoproteome R. N. Joshi, F. Marabita, N. Binai, Z. Sui, A. Altman, A. J. Heck, J. Tegner, A. Schmidt, Stockolm, Sweden BS.C.01.04 Prophylacic treatment with novel forms of allergen-laden virus like-nanoparicles (VNP) induces speciic tolerance in a mouse model of allergy B. Kratzer, C. Köhler, S. Hofer, U. Smole, D. Trapin, J. Iturri, D. Pum, P. Kienzl, A. Elbe-Bürger, P. Gainger, I. Mitermann, B. Linhart, Y. Dorofeeva, B. Jahn-Schmid, A. Neunkirchner, R. Valenta, W. F. Pickl, Vienna, Austria BS.C.01.05 Macrophages require CD200 receptor to resolve inlammatory pain R. Raoof, M. van der Vlist, H. Willemen, J. Prado Sanchez, L. Meyaard, N. Eijkelkamp, Utrecht,

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Netherlands BS.C.01.06 Tissue-resident memory CD8+ T cells form systemic efector and memory responses but ‘remember’ their site of origin F. M. Behr, T. H. Wesselink, L. Parga Vidal, N. A. Kragten, R. Stark, K. P. van Gisbergen, Amsterdam, Netherlands WS.C6.01 Acquired immunity crosstalk with inlammaion 8:30 - 9:45 E104-107 Chairpersons: David Sancho, Spain & Joke den Haan, The Netherlands WS.C6.01.01 hIPSC-derived dendriic cells idenify IRF5 as a crucial regulator that exacerbates inlammatory cytokine producion during Inluenza A virus infecion J. L. Forbester, M. Clement, A. Yeung, P. Sabberwal, M. Marsden, G. Dougan, I. Humphreys, Cardif, United Kingdom WS.C6.01.02 SOCS1 and SOCS3 target IRF7 degradaion to suppress TLR7- mediated type I interferon producion of human plasmacytoid dendriic cells C. Yu, W. Peng, M. Schlee, W. Barchet, A. M. Eis-Hübinger, W. Kolanus, M. Geyer, S. Schmit, F. Steinhagen, J. Oldenburg, N. Novak, Bonn, Germany WS.C6.01.03 The dialogue between mast cells and B lymphocytes may precipitate atherosclerosis complicaions A. Loste, K. Guedj, M. Clement, S. Delbosc, M. Morvan, G. Even, A. Gaston, M. Arock, A. Eggel, J. B. Michel, G. Caligiuri, A. Nicolei, M. Le Borgne, Paris, France WS.C6.01.04 A role for DPP4 in T cell-mediated vascular inlammaion and Atherosclerosis J. Zhong, L. Duan, C. Xia, J. Varghese, G. Mihai, X. Rao, S. Rajagopalan, Cleveland, United States WS.C6.01.05 VISTA expression by microglia decreases during inlammaion and is diferenially regulated in CNS diseases M. Borggrewe, C. Grit, W. F. den Dunnen, S. M. Burm, J. J. Bajramovic, R. J. Noelle, B. J. Eggen, J. D. Laman, Groningen, Netherlands WS.C6.01.06 CLEC12A regulates neutrophil funcioning in Rheumatoid arthriis L. Whitehead, P. Morvay, P. Redelinghuys, I. Dambuza, S. Ansboro, A. J. Roelofs, D. M. Reid, J. A. Willment, C. De Bari, I. B. McInnes, G. D. Brown, Aberdeen, United Kingdom WS.C2.01 Signaling in autoimmunity 8:30 - 9:45 G102-103 Chairpersons: Renoud Lesourne, France & Hannes Stockinger, Austria WS.C2.01.01 Inducion of gliadin-speciic immune inhibiion following treatment with Tolerogenic Immune Modifying Nanoparicles (TIMP) containing-gliadin J. R. Podojil, T. L. Freitag, R. Pearson, D. Gets, L. D. Shea, S. D. Miller, Chicago, United States WS.C2.01.02 Inhibiion of arginase-1 expression by the transcripion factor Fra-1 in macrophages exacerbates rheumatoid arthriis inlammaion N. Hannemann, S. Cao, A. Schnelzer, J. Jordan, M. Eberhardt, U. Schleicher, S. Uebe, A. Ekici, J. Rech, T. Bäuerle, C. Bogdan, J. Vera, G. Schet, A. Bozec, Erlangen, Germany WS.C2.01.03 OPAL1, a novel transmembrane adaptor protein regulates CXCR4 signalling Š. Borna, A. Drobek, J. Králová, M. Fabišik, T. Brdička, Prague, Czech Republic WS.C2.01.04 FcγR-TLR cross-talk promotes inlammaion by human anigen presening cells via IRF5- dependent gene transcripion and glycolyic reprogramming W. Hoepel, L. T. Vogelpoel, I. S. Hansen, M. L. Kapsenberg, D. L. Baeten, B. Everts, J. den Dunnen, Amsterdam, Netherlands WS.C2.01.05 Transmembrane TNF signaling through TNF-RI induces SpA-like inlammaion, whereas signaling through TNF-RII is crucial for new bone formaion M. van Tok, D. Pots, I. Blijdorp, M. Armaka, G. Kollias, M. van de Sande, D. Baeten, L. van Duivenvoorde, Amsterdam, Netherlands WS.C2.01.06 Lactate, via SLC5A12, lights up inlammaion in CD4+ T cells by inducing a metabolic reprogramming V. Pucino, M. Certo, D. Cucchi, M. Lewis, K. Goldmann, M. Bombardieri, C. Pitzalis, C. Mauro, London, United Kingdom WS.C5.02 Immunotherapy of allergic disorders 8:30 - 9:45 G106-107 Chairpersons: Oscar Palomares, Spain & Heimo Breiteneder, Austria WS.C5.02.01 Selecive eliminaion of allergen-speciic B lymphocytes with chimeric protein-engineered molecules N. R. Ralchev, N. Mihaylova, N. Kerekov, A. Tchorbanov, Soia, Bulgaria 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 71 Tuesday, September 4th, 2018 ECI2018

WS.C5.02.02 Sulfated Non-Anicoagulant Heparin (S-NACH) blocks allergen induced asthma manifestaions in mice by modulaing the IL-4/STAT6/GATA-3 pathway harboring a therapeuic potenial for allergic asthma M. A. Ghonim, J. Wang, S. Ibba, K. Pyakurel, H. Luu, I. Benslimane, S. Mousa, H. Boulares, New Orleans, LA, United States WS.C5.02.03 Targeing PDE3 Abrogates the Hallmarks of Asthma in Asthma Models A. KleinJan, J. Beute, K. Ganesh, V. Bos, M. Lukkes, M. v. Nimwegen, S. Hockman, V. Manganiello, R. Hendriks, Roterdam, Netherlands WS.C5.02.04 Neutrophils negaively regulate TH2 inlammaion in allergic airways disease by limiing G-CSF driven monocytosis and ILC2 cytokine producion D. F. Patel, T. Peiro, J. Vuononvirta, S. Akthar, S. A. Walker, L. G. Gregory, C. M. Lloyd, R. J. Snelgrove, London, United Kingdom WS.C5.02.05 NOD/SCID-mice engrated with human allergen-speciic CD4+ T cells develop allergic airway responses without signs of GvHD C. Vizzardelli, F. Zimmann, M. Gindl, B. Nagl, C. Kitzmüller, U. Vollmann, S. Tangermann, L. Kenner, B. Bohle, Vienna, Austria WS.C5.02.06 Inducion of in vitro cross-tolerance in birch pollen-allergic paients with associated food allergies by use of tolerogenic dendriic cells P. V. Rostan, E. Graulich, V. K. Raker, A. Wangorsch, S. Scheurer, K. Steinbrink, Mainz, Germany WS.C2.02 Neuroinlammatory disorders 10:15 - 11:30 G102-103 Chairpersons: Milan Buc, Slovakia & Marvin van Luijn, The Netherlands WS.C2.02.01 Eicient suppression of efector T cells isolated from muliple sclerosis paients by autologous, UniCAR-engrated Tregs A. Kegler, S. Koristka, C. Arndt, A. Feldmann, S. Albert, G. Ehninger, M. Bornhäuser, M. Schmitz, K. Akgün, T. Ziemssen, M. Bachmann, Dresden, Germany WS.C2.02.02 Elucidaion of pro-resolving lipid mediators in the cerebrospinal luid: implicaions for muliple sclerosis pathogenesis G. Kooij, V. Chiurchiù, G. Enzmann, P. Norris, M. Khameni, B. Engelhardt, H. E. de Vries, C. Serhan, Amsterdam, Netherlands WS.C2.02.03 Characterizing human CD20+ T cells and their role in muliple sclerosis M. von Essen, C. Ammitzbøll, R. Hansen, O. McWilliam, E. Petersen, H. Marquart, F. Sellebjerg, Copenhagen, Denmark WS.C2.02.04 Malat-1 LncRNA regulates inlammaion and T cell difereniaion in an animal model of muliple sclerosis F. Masoumi, S. Ghorbani, F. Talebi, F. Noorbakhsh, Tehran, Islamic Republic of Iran WS.C2.02.05 Dimethyl fumarat limits Tc17 cell fate in autoimmunity via ROS accumulaion C. Lückel, H. Raifer, L. Campos Carrascosa, S. Moos, F. Kurschus, F. Marini, M. Klein, T. Bopp, Y. Chao, C. Zielinski, L. Bonei, M. Grusdat, D. Brenner, B. Tackenberg, M. Huber, Mainz, Germany WS.C2.02.06 The TH17-associated cytokine interleukin-26 regulates central nervous system barrier funcion B. Broux, E. Peelen, E. Gowing, S. Zandee, M. Charabai, M. Lécuyer, L. Hachehouche, L. Bourbonnière, C. Pitet, S. Larouche, J. I. Alvarez, A. Bouthillier, R. Moumdjian, P. Duquete, N. Arbour, A. Prat, Diepenbeek, Belgium WS.C1.02 Immune regulaion at mucosal sites 10:15 - 11:30 G104-105 Chairpersons: Bruno Lucas, France & Raivo Uibo, Estonia WS.C1.02.01 Intesinal Secretory Leukocyte Protease Inhibitor expression is increased in pediatric inlammatory bowel disease paients and is unfavorable during murine coliis S. Nugteren, C. L. Menckeberg, Y. Simons-Oosterhuis, D. J. Lindenbergh-Kortleve, L. A. van Berkel, H. C. Raatgeep, L. M. Costes, L. de Ridder, J. C. Escher, J. N. Samsom, Roterdam, Netherlands WS.C1.02.02 ATF3 sustains IL22-induced stat3 phosphorylaion to regulate intesinal mucosal immunity during homeostasis and stress D. Glal, Taipei, Taiwan WS.C1.02.03 The transcripion factor MAF regulates homeostasis in colonic T cells C. Imbrata, M. Leblond, D. Velin, D. E. Speiser, G. Verdeil, Epalinges, Switzerland WS.C1.02.04 Proinlammatory, high avidity CD4+ T cells with a memory-like phenotype in the human fetal intesine

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N. Li, V. van Unen, T. Abdelaal, K. Ladell, J. E. McLaren, D. A. Price, S. M. Chuva de Sousa Lopes, B. P. Lelieveldt, F. Koning, Leiden, Netherlands WS.C1.02.05 The transcripion factor NFATc3 promotes intesinal inlammaion by suppression of regulatory T cells K. Gerlach, V. Popp, M. Neurath, B. Weigmann, Erlangen, Germany WS.C1.02.06 The molecular composiion of IgA ani-carbamylated and ani-citrullinated protein anibodies in Rheumatoid Arthriis, point to a mucosal origin M. A. M. van Delt, M. K. Verheul, N. Levarht, L. Hakenscheid, T. Kissel, A. Bondt, T. W. Huizinga, R. E. Toes, L. A. Trouw, Leiden, Netherlands WS.C6.02 New mediators in inlammaion and its resoluion 16:30 - 17:45 G104-105 Chairpersons: Flavia Bazzoni, Italy & Chrisian Neumann, Germany WS.C6.02.01 PPAR-γ modulates macrophage response to lipopolysaccharide and glucocoricoids M. Heming, S. Gran, S. Jauch, L. Fischer-Riepe, A. Russo, L. Klotz, S. Hermann, M. Schaefers, J. Roth, K. Barczyk-Kahlert, Muenster, Germany WS.C6.02.02 Ani-inlammatory microRNA-146a protects mice from diet-induced metabolic disease M. C. Runtsch, M. Nelson, R. M. O‘Connell, Dublin, Ireland WS.C6.02.03 IFNb is a novel efector cytokine in resolving inlammaion A. Ariel, S. K. Satyanarayanan, S. Soboh, S. Butenko, J. Saadi, A. kassis, A. kassis, N. Peled, N. Sher, S. Schif-Zuck, Haifa, Israel WS.C6.02.04 CXCL9(74-103) reduces neutrophil recruitment and joint inlammaion in experimental arthriis D. Bof, H. Crijns, R. Janssens, V. Vanheule, G. B. Menezes, S. Macari, T. A. Silva, F. A. Amaral, P. Proost, Leuven, Belgium WS.C6.02.05 Inhibiion of neutrophil extravasaion with a CXCL9-derived glycosaminoglycan-binding pepide P. Proost, V. Vanheule, A. Morier, H. Crijns, D. Bof, R. Janssens, S. Struyf, F. A. Amaral, M. M. Teixeira, Leuven, Belgium WS.C6.02.06 Mechanisms by which lung surfactant protein SP-A ampliies IL-4-mediated efects on alveolar macrophages C. Casals, B. García-Fojeda, C. Montero-Fernández, C. Stamme, C. M. Minui, Madrid, Spain Symposia and Workshops Track D S.D3 Novel approached to vaccinology 14:45 - 16:00 Auditorium Chairpersons: Àfrica Gonzàlez-Fernàndez, Spain & Peter Openshaw, United Kingdom S.D3.01 Viral vaccine delivery systems Sarah Gilbert, United Kingdom S.D3.02 Broadly neutralizing anibodies targeing HIV-1 Florian Klein, Germany S.D3.03 Therapeuic monoclonal anibodies Antonio Lanzavecchia, Switzerland BS.D.01 Bright Sparks Workshop 10:15 - 11:30 Auditorium Chairpersons: Shohreh Issazadeh-Navikas, Denmark & Bojan Polic, Croaia BS.D.01.01 Intesinal IgA shows speciic broad binding to phylogeneically non-related bacteria J. Kabbert, H. Wardemann, O. Pabst, Aachen, Germany BS.D.01.02 Oxysterol sensing through the receptor GPR183 promotes the lymphoid issue-inducing funcion of innate lymphoid cells and coliis J. Emgård, H. Kammoun, B. García-Cassani, J. Chesné, S. Parigi, J. Jacob, H. Cheng, E. Evren, S. Das, P. Czarnewski, N. Sleiers, F. Melo-Gonzalez, E. Kvedaraite, M. Svensson, E. Scandella, M. Hepworth, S. Huber, B. Ludewig, L. Peduto, E. Villablanca, H. Veiga-Fernandes, J. Pereira, R. Flavell, T. Willinger, Stockholm, Sweden BS.D.01.03 Eomes broadens the scope of CD8 T cell memory by inhibiing apoptosis in low-ainity cells I. Kavazović, E. Slinger, G. Balzarei, P. Klarenbeek, H. Han, N. A. Lemmermann, A. ten Brinke, J. Koster, S. Jonjić, N. de Vries, Y. Bryceson, B. Polić, E. Eldering, F. M. Wensveen, Rijeka, Croaia BS.D.01.04 Pentraxin3 Regulates IL-17A Mediated Immunity to Leishmania G. Gupta, P. Jia, J. E. Uzonna, Winnipeg, Canada BS.D.01.05 Imaging the host-pathogen interacion in tuberculosis in a bioelectrospray 3D cell culture

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 73 Tuesday, September 4th, 2018 ECI2018

model E. Konstaninopoulou, L. B. Tezera, S. Mahajan, P. T. Elkington, Southampton, United Kingdom BS.D.01.06 Single cell analysis reveals funcional heterogeneity within plasmacytoid dendriic cells and ideniies environmental cues that drive type I IFN producion F. Wimmers, N. Subedi, D. Heister, N. van Buuringen, J. Vivié, I. Beeren-Reinieren, R. Woestenk, H. Dolstra, A. Piruska, A. van Oudenaarden, C. Figdor, W. Huck, J. de Vries, J. Tel, Eindhoven, Netherlands WS.D4.04 Virus-host interacions 8:30 - 9:45 Forum Chairpersons: Sonja Buschow, The Netherlands & Natalia Munoz-Wolf, Ireland WS.D4.04.01 Human cytomegalovirus reprograms hematopoieic progenitor cells into immunosuppressive monocytes to achieve latency K. Zen, Atlanta, China WS.D4.04.02 Killer cell proteases target viral immediate-early proteins to control cytomegalovirus infecion in a noncytotoxic manner L. Shan, J. Meeldijk, B. Blijenberg, A. Hendriks, K. J. van Boxtel, S. P. van den Berg, A. Svrlanska, T. Stamminger, M. R. Wills, N. Bovenschen, Utrecht, Netherlands WS.D4.04.03 Pathological role of ani-CD4 anibodies in HIV-infected immunologic non-responders under viral suppressive aniretroviral therapy W. Jiang, Z. Luo, Charleston, United States WS.D4.04.04 HIV-1 exposure enhances sexual transmission of HCV by inducing Syndecan-4 on Langerhans cells B. M. Nijmeijer, R. Sarrami Forooshani, J. Eder, G. S. Steba, R. R. Schreurs, S. M. Koekkoek, R. Molenkamp, J. Schinkel, P. Reiss, M. L. Siegenbeek van Heukelom, M. van der Valk, C. M. Ribeiro, T. B. Geijtenbeek, Amsterdam, Netherlands WS.D4.04.05 DUSP4 regulates STING and RIG-I mediated signalling in response to virus infecion H. Jiao, S. J. James, Y. Zhang, Singapore, Singapore WS.D4.04.06 A lncRNA promotes viral replicaion by modulaing host cellular metabolism P. Wang, J. Xu, Y. Wang, X. Cao, Shanghai, China WS.D4.05 Innate-adapive interface during microbial infecions 10:15 - 11:30 G106-107 Chairpersons: Maritsa Margaroni, Greece & Sean Wategedera, United Kingdom WS.D4.05.01 Targeing newly ideniied pathogenic monocyte subsets with immune-modulatory treatment resolves severe malaria P. Niewold, A. Cohen, C. van Vreden, D. R. Gets, G. Grau, N. King, Sydney, Australia WS.D4.05.02 The use of mass cytometry to study type 2 immune responses in the context of helminth infecions K. de Ruiter, D. L. Tahapary, K. Stam, V. van Unen, E. Sartono, J. W. Smit, T. Supali, M. Yazdankbakhsh, Leiden, Netherlands WS.D4.05.03 The Notch signaling pathway controls basophil responses during helminth-induced type 2 inlammaion L. M. Webb, S. A. Peng, O. O. Oyesola, R. L. Cubit, J. K. Grenier, C. G. Danko, E. D. Tait Wojno, Ithaca, United States WS.D4.05.04 Type I Interferons Suppresses Ani-parasiic CD4+T Cell Responses in Visceral Leishmaniasis R. Kumar, P. Bunn, F. Rivera, N. Singh, S. Sundar, C. Engwerda, Varanasi, India WS.D4.05.05 Cross-presentaion by pDC of cell-associated HIV is poteniated by non-cognate CD8 T+ cell pre-acivaion E. X. Haton, S. Isnard, M. Ianneta, J. Guillerme, A. Hosmalin, Paris, France WS.D4.05.06 Memory CD8 T cell inlaion versus issue resident memory T cells: same patrollers, same controllers? S. P. M. Welten, A. Oxenius, Zürich, Switzerland WS.D1.01 Mucosal immune regulaion 14:45 - 16:00 G106-107 Chairpersons: Birgit Strobl, Austria & Helena Tlaskalova-Hogenova, Czech Republic WS.D1.01.01 Transcripion factor c-Maf is required for the control of Th17 cell responses by intesinal regulatory T cells H. Hussein, S. Denanglaire, Y. Ajouaou, O. Leo, F. Andris, Gosselies, Belgium WS.D1.01.02 Inducion of intesinal Th22 cells by segmented ilamentous bacteria U. Roy, E. Galvez, A. Gronow, M. Basic, A. Bleich, S. Huber, T. Strowig, Braunschweig, Germany 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 74 Tuesday, September 4th, 2018 ECI2018

WS.D1.01.03 Microbiota sensing by a Mincle-Syk axis in dendriic cells promotes intesinal immune barrier via the steady-state regulaion of IL-17 and IL-22 M. Marínez-López, S. Iborra, A. Mastrangelo, R. Conde-Garrosa, C. Danne, D. M. Reid, G. D. Brown, D. Bernardo, S. Leibundgut-Landmann, D. Sancho, Madrid, Spain WS.D1.01.04 Control of RORγt+ regulatory T cell difereniaion and intesinal immune homeostasis is dependent on the transcripion factor c-Maf C. Neumann, J. Blume, A. Vasanthakumar, A. Beller, U. Roy, Y. Liao, F. Heinrich, C. Stehle, G. A. Heinz, P. Maschmeyer, T. Sidwell, Y. Hu, D. Amsen, C. Romagnani, H. Chang, A. Kruglov, M. Mashreghi, W. Shi, T. Strowig, S. Rutz, A. Kallies, A. Schefold, Berlin, Germany WS.D1.01.05 IL-17 receptor signaling in intesinal secretory progenitor cells regulates epithelial cells regeneraion P. Kumar, M. Beaupre, K. Chang, A. Banerjee, T. Chu, H. Huang, X. Lin, S. Khalid, P. Joshi, A. Bialowska, V. Yang, Stony Brook, United States WS.D1.01.06 Ani-commensal IgG augments intesinal inlammaion in ulceraive coliis via IL-1 beta- dependent type 17 immunity T. Castro-Dopico, T. W. Dennison, J. R. Ferdinand, R. Mathews, D. Clit, B. Stewart, C. Jing, K. Strongili, E. Monk, K. Saeb-Parsy, C. E. Bryant, M. Parkes, M. Clatworthy, Cambridge, United Kingdom WS.D4.06 Bacterial infecions and immune acivaion 16:30 - 17:45 G102-103 Chairpersons: David Holden, United Kingdom & Silvia Cellone Trevelin, United Kingdom WS.D4.06.01 A novel mechanism of neutrophil entry into epithelial cells is involved in damping inlammaion but exposes a backdoor for bacterial invasion N. Y. Shpigel, Rehovot, Israel WS.D4.06.02 Lung surfactant lipids provide immune protecion against non-typeable Haemophilus inluenzae respiratory infecion B. Garcia-Fojeda, Z. Gonzalez-Carnicero, A. De Lorenzo, C. Minui, B. Euba, A. Iglesias-Ceacero, S. Casillo-Lluva, J. Garmendia, C. Casals, Madrid, Spain WS.D4.06.03 CD200R1L, a novel acivaing receptor on human neutrophils that induces ROS and NET release M. Ramos, J. Stok, C. Kesmir, T. Jansen, L. Meyaard, M. van der Vlist, Utrecht, Netherlands WS.D4.06.04 Innate immune recogniion of Staphylococcus aureus by dendriic cells is afected by anibioic resistance mutaions T. P. Paton, J. Jiang, R. J. Lundie, V. Oorschot, G. Ramm, A. Y. Peleg, M. A. O‘Keefe, Melbourne, Australia WS.D4.06.05 Hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing S. Chen, Q. Liu, ShangHai, China WS.D4.06.06 Analysis of CD6-based pepides in experimental sepsis C. Català, M. Marínez-Florensa, M. Velasco-de Andrés, O. Cañadas, V. Fraile-Ágreda, S. Casadó-Llombart, N. Armiger-Borràs, M. Consuegra-Fernández, C. Casals, F. Lozano, Barcelona, Spain WS.D2.02 Molecular and cellular features of ILCs 16:30 - 17:45 E102 Chairpersons: James Di Santo, France & Jenny Mjösberg, Sweden WS.D2.02.01 Hobit speciically ideniies ILC1 throughout peripheral issues R. L. R. Taggenbrock, N. A. Kragten, F. M. Behr, L. Parga Vidal, T. H. Wesselink, R. Stark, G. Gasteiger, K. P. van Gisbergen, Amsterdam, Netherlands WS.D2.02.02 Human IL-17-producing type 2 innate lymphoid cells are important regulators of neutrophilia in cysic ibrosis K. Golebski, X. R. Ros, M. Nagasawa, B. A. Heesters, C. M. van Drunen, W. J. Fokkens, H. Spits, S. M. Bal, Amsterdam, Netherlands WS.D2.02.03 ILC migraion between barriers sites and draining lymphoid issue E. Duton, C. Willis, A. Camelo, M. Sleeman, G. Carlesso, R. Herbst, A. Humbles, D. Withers, Birmingham, United Kingdom WS.D2.02.04 The chemokine receptor CCR8 regulates efector funcions of group 2 innate lymphoid cells L. Knipfer, A. Schulz-Kuhnt, M. Kindermann, T. Primbs, D. Vöhringer, M. Neurath, I. Atreya, S. Wirtz, Erlangen, Germany WS.D2.02.05 Molecular deiniion of group 1 innate lymphoid cells in the mouse uterus

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 75 Tuesday, September 4th, 2018 ECI2018

I. Filipovic, L. Chiossone, P. Vacca, R. S. Hamilton, J. Doisne, A. Sharkey, C. Mingari, L. Moreta, F. Colucci, Cambridge, United Kingdom WS.D2.02.06 NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 simulaion in mice Y. Mikami, G. Scarno, B. Zii, H. Shih, Y. Kanno, A. Santoni, J. J. O‘Shea, G. Sciume, Rome, Italy Symposia and Workshops Track E S.E2 How to handle big data and can we do this? 16:30 - 17:45 Elicium Chairpersons: Angela Santoni, Italy & Thomas Kamradt, Germany S.E2.01 How to make sense out of big data in immunology: The single cell genomics revoluion as an example Jacques Neejes, The Netherlands S.E2.02 Pro & Con Discussion Joachim Schultze, Germany & Rolf Zinkernagel, Switzerland WS.E1.01 Visualizing immune responses 8:30 - 9:45 E102 Chairpersons: Ewoud Compeer, United Kingdom & Zoltan Peter Jakus, Hungary WS.E1.01.01 A hot trick for eicient pepide exchange on MHC class I mulimers J. J. Luimstra, M. A. Garstka, M. C. Roex, F. H. Falkenburg, J. Neejes, H. Ovaa, Leiden, Netherlands WS.E1.01.02 Chemokines and integrins independently tune acin low and substrate fricion during intranodal migraion of T cells M. Hons, A. Kopf, R. Hauschild, A. Leithner, F. Gärtner, J. Abe, J. Renkawitz, J. V. Stein, M. Sixt, Klosterneuburg, Austria WS.E1.01.03 Inside the infected lung - Watching immune cells batle Aspergillus fumigatus S. Henneberg, S. Krappmann, L. Bornemann, M. Hasenberg, J. Weski, A. Hasenberg, M. Gunzer, Essen, Germany WS.E1.01.04 Imaging of cytotoxic aniviral immunity while considering the 3R principle of animal research L. Oto, G. Zelinskyy, M. Schuster, U. Ditmer, M. Gunzer, Essen, Germany WS.E1.01.05 Visualisaion of immune receptor sequences via projecion into high-dimensional space with Siamese neural networks V. I. Nazarov, E. Oitserov, V. Tsvetkov, Moscow, Russian Federaion WS.E1.01.06 Intravascular resident Natural Killer cells shape neutrophil dynamics in the pulmonary vasculature J. Secklehner, K. De Filippo, J. B. Mackey, J. Vuononvirta, X. Rafo Iraolagoiia, A. McFarlane, M. Neilson, M. B. Headley, M. Krummel, N. Guerra, L. M. Carlin, London, United Kingdom Joint Symposia (see also p. 35) JS.06 From immunological insight to prevenion of allergy (EAACI) 13:15 - 14:30 Elicium Chairpersons: Edward Knol, The Netherlands & Jürgen Schwarze, United Kingdom JS.06.01 Microbial inducion of immune tolerance at mucosal surfaces Liam O’Mahony, Ireland JS.06.02 Immunoregulatory roles of lipid mediators in asthma and allergy Milena Sokolowska, Switzerland JS.06.03 Novel dendriic cell vaccines for the prevenion and treatment of allergic diseases Oscar Palomares, Spain JS.07 Subversion of phagocytosis in innate immunity: from eferocytosis to pathogen interacion (SLB) 13:15 - 14:30 Auditorium Chairpersons: Pieter Leenen, The Netherlands & Véronique Witko-Sarsat, France JS.07.01 Neutrophils as targets for host-directed therapy against tuberculosis Tobias Dellenga, Germany JS.07.02 Diferenial signaling through TLR7 or TLR8 determines the phenotype of human monocytes during RNA viral infecion Margarita Dominguez-Villar, United States of America 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 76 Tuesday, September 4th, 2018 ECI2018

JS.07.03 Eferocytosis induces a novel SLC program to promote glucose uptake and lactate release Jusin Perry, United States of America JS.08 Cytometry Building Bridges (ISAC) 13:15 - 14:30 Forum Chairpersons: Hyun-Dong Chang, Germany & Andrea Cossarizza, Italy JS.08.01 Cytometry of aging of the immune system Andrea Cossarizza, Italy JS.08.02 Cytometry of intesinal microbiota Hyun-Dong Chang, Germany JS.08.03 Standardizing cytometry of primary immunodeiciencies Tomas Kalina, Czech Republic JS.09 The gut microbiota and the IgA anibody producion in health and disease (SMI) 13:15 - 14:30 E104-107 Chairpersons: Oliver Pabst, Germany & Jo Spencer, United Kingdom JS.09.01 IgA, microbiota and cancer Maria Rescigno, Italy JS.09.02 Anibodies set boundaries limiing microbial metabolite penetraion and the resultant mammalian host response Andrew Macpherson, Switzerland JS.09.03 The regulatory microenvironment in Peyer‘s patches leading to synchronized gut IgA responses Nils Lycke, Sweden JS.10 Innate host pathogen interacions (JSI) 13:15 - 14:30 G106-107 Chairpersons: Esther de Jong, The Netherlands & Shimon Sakaguchi, Japan JS.10.01 Protecive role of Mincle in bacterial infecion Sho Yamasaki, Japan JS.10.02 LILR family receptors in host pathogen interacions Hisashi Arase, Japan JS.10.03 ILC2 and type 2 immune diseases Kazuyo Moro, Japan An expert’s guide to publishing – Sponsored by Wiley EGP.01 An expert’s guide to publishing 13:15 - 14:30 G104-105 Chairperson: Nadja Bakocevic, Wiley Panelists: Danny Altmann, EiC, Immunology Chrisine Fears, Journals Manager, Briish Society for Immunology Peter Hoglund, EiC, Scandinavian Journal of Immunology Jürgen Wienands, Execuive Commitee Member and Editor, European Journal of Immunology

Program: EGP.01.01 Preparing your manuscript EGP.01.02 Mastering the peer review process EGP.01.03 Maximising the impact of your work EGP.01.04 Bridging the gap from author to editor

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 77 Tuesday, September 4th, 2018 ECI2018 Poster Sessions, Tuesday, September 4th, 2018 Track A – Immune development and differentiation P.A1.02 Myeloid lineage speciicaion - Part 2 P.A2.02 Immune development and aging from the cradle to the grave - Part 2 P.A3.03 Immunomonitoring and biomarkers - Part 3 P.A3.04 Immunomonitoring and biomarkers - Part 4 P.A3.05 Immunomonitoring and biomarkers - Part 5 P.A4.02 Germinal centers and B cell difereniaion - Part 2 P.A5.03 Iniiaion of immune responses - Part 3 P.A5.04 Iniiaion of immune responses - Part 4 P.A6.02 Lessons learned from the geneic defects - Part 2 Track B – Tumor immunology and therapy P.B1.04 Tumor vaccinaion principles and Immunotherapy - Part 4 P.B1.05 Tumor vaccinaion principles and Immunotherapy - Part 5 P.B1.09 Tumor vaccinaion principles and Immunotherapy - Part 9 P.B2.03 Environmental regulaion ani-tumor responses - Part 3 P.B2.04 Environmental regulaion ani-tumor responses - Part 4 P.B2.05 Environmental regulaion ani-tumor responses - Part 5 P.B3.03 T-cell regulaion - Part 3 P.B4.02 T-cell acivaion and exhausion - Part 2 Track C – Autoimmunity, Allergy and Transplantation P.C1.04 Maintenance and local regulaion of issue speciic immunity - Part 4 P.C1.05 Maintenance and local regulaion of issue speciic immunity - Part 5 P.C2.04 Immune signaling and therapy in autoimmunity - Part 4 P.C2.05 Immune signaling and therapy in autoimmunity - Part 5 P.C2.06 Immune signaling and therapy in autoimmunity - Part 6 P.C2.07 Immune signaling and therapy in autoimmunity - Part 7 P.C3.02 Regulatory Mechanisms in Transplantaion P.C4.02 Manipulaion of tolerance - Part 2 P.C5.02 Allergy, asthma and therapy - Part 2 P.C6.03 Innate control of inlammaion and issue repair - Part 3 P.C6.04 Innate control of inlammaion and issue repair - Part 4 Track D – Infections and microbial immune regulation P.D1.03 Microbiome, metabolites and the immune system - Part 3 P.D2.01 Innate Lymphoid Cells P.D3.03 Novel approaches to vaccinology - Part 3 P.D4.04 Exploiing host pathogen interacion - Part 4 P.D4.05 Exploiing host pathogen interacion - Part 5 P.D4.06 Exploiing host pathogen interacion - Part 6 Track E – Technical advances and big data P.E1.02 Visualizing immune responses - Part 2 P.E3E4.01 From single cells to populaion dynamics / Cell communicaion and signaling in the immune system

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 78 Wednesday, September 5th, 2018 ECI2018 Oral Sessions, Wednesday, September 5th, 2018 Keynote Lectures (details p. 45) KL.07 Keynote Lecture 07 15:45 - 16:30 Elicium Chairpersons: Jacques Neejes,The Netherlands & Jessica Strid, United Kingdom KL.07 The unsuspected role of gut microbiota in cancer therapeuics Laurence Zitvogel, France KL.08 Keynote Lecture 08 15:45 - 16:30 Auditorium Chairpersons: Deborah Dunn-Walters, United Kingdom & Marieke van Ham, The Netherlands KL.08 The maintenance and mobilizaion of resident immune memory cells Andreas Radbruch, Germany Late Breaking Hot Topics HT.07 Late Breaking Hot Topic 07 15:30 - 15:45 Elicium Chairpersons: Jacques Neejes, The Netherlands & Jessica Strid, United Kingdom HT.07.01 Anibodies set boundaries limiing microbial metabolite penetraion and the resultant mammalian host response H. Li, Y. Uchimura, T. Fuhrer, U. Sauer, A. Macpherson, Zurich, Switzerland HT.08 Late Breaking Hot Topic 08 15:30 - 15:45 Auditorium Chairpersons: Deborah Dunn-Walters, United Kingdom & Marieke van Ham, The Netherlands HT.08.01 New Insights into the Biology of Secreted IgD D. Segura-Garzon, Barcelona, Spain EFIS President’s Symposium (see also p. 10) EP.01 T Cell immunity in the front line 10:15 - 11:45 Elicium Chairperson: René van Lier (EFIS President) EP.01.01 Generaion and maintenance of human issue resident memory T cells Donna Farber, United States of America EP.01.02 Local regulaion of immune responses and improving adapive T cell immunity to overcome chronic infecions Percy Knolle, Germany EP.01.03 Difereniaion of issue-resident memory T-cells in primary and secondary immune responses Klaas van Gisbergen, The Netherlands Workshops Track A WS.A2.04 Evoluion of immune responses in health and disease 13:45 - 15:00 G106-107 Chairpersons: Sara De Biasi, Italy & Pauline van Schouwenburg, The Netherlands WS.A2.04.01 Hematopoieic progenitors from old humans are metabolically acive but present evidence of cellular senescence and pyroptosis T. Fali, V. Fabre Mersseman, T. Yamamoto, J. Boddaert, D. Sauce, V. Appay, Paris, France, WS.A2.04.02 IMMUNOBIOGRAM a new immunological tool to personalize immunosuppressive therapy in kidney transplant recipients M. Di Scala, J. Portolés, C. Jiménez, D. Janeiro, E. González, B. Sánchez Sobrino, M. López Oliva, J. Richter, A. Ortega, J. Pascual, I. Portero, Madrid, Spain WS.A2.04.03 Paricular neutrophils mediate environment-driven onset of airway allergy through NETs release C. Radermecker, C. Sabatel, S. Johnston, M. Toussaint, F. Bureau, T. Maricha, Sart-Tilman, Belgium WS.A2.04.04 Alpha-Gal bound to lipids, but not to proteins, is able to cross the intesinal epithelium and might thus cause delayed allergic symptoms in meat allergic paients

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 79 Wednesday, September 5th, 2018 ECI2018

P. Román-Carrasco, B. Lieder, V. Somoza, M. Ponce, Z. Szépfalusi, D. Marín, W. Hemmer, I. Swoboda, Vienna, Austria WS.A2.04.05 Cytofast: A worklow for low and mass cytometry data to discover group-related immune signatures G. Beyrend, K. Stam, T. Höllt, R. Arens, Leiden, The Netherlands WS.A2.04.06 A novel algorithm for analysis оf the evoluion of B-cell receptors repertoires using high- throughput sequencing data A. S. Obraztsova, M. Shugay, D. M. Chudakov, Moscow, Russian Federaion Symposia and Workshops Track B S.B4 T cell acivaion and exhausion 12:00 - 13:15 Elicium Chairpersons: Michael Lohof, Germany & Shohreh Issazadeh-Navikas, Denmark S.B4.01 T cell heterogeneity in human cancer Ton Schumacher, The Netherlands S.B4.02 Immunodeiciencies associated with increased T cell senescence Sven Kracker, France S.B4.03 Maintenance of “exhausted” T cells in chronic infecion Dietmar Zehn, Germany WS.B4.02 Targeing checkpoints 8:30 - 9:45 Forum Chairpersons: Magdalena Huber, Germany & Nada Pejnovic, Serbia WS.B4.02.01 Improving ani-CD137 immunotherapy against muliple myeloma through PD1 blockade A. C. Pichler, Toulouse, France WS.B4.02.02 PD-1 Signals are Criical for Maintenance of Funcional CD8 T Cell Memory S. Sarkar, Y. Yuzefpolskiy, F. Baumann, K. Ernst-Bernhard, M. Prlic, P. Nghiem, S. Riddell, M. Sedensky, P. Morgan, M. C. Jensen, V. Kalia, Seatle, United States WS.B4.02.03 Combinaion therapy with ani-PD-L1 anibody and depleion of regulatory T cells during acute viral infecions results in improved virus control but lethal immunopathology M. Drabczik-Pluta, P. David, E. Pasille, T. Knuschke, T. Werner, N. Honke, A. M. Westendorf, K. S. Lang, U. Ditmer, G. Zelinskyy, Essen, Germany WS.B4.02.04 Plasicity of Tc17 cells is regulated by CTLA-4 via STAT1/3 A. Arra, H. Lingel, B. Kuropka, T. Fischer, C. Freund, M. Pierau, M. Brunner-Weinzierl, Magdeburg, Germany WS.B4.02.05 De novo DNA methylaion programming restrains T cell rejuvenaion during immune checkpoint blockade therapy H. Ghoneim, A. Moustaki, H. Abdelsamed, Y. Fan, P. Thomas, E. Stewart, S. Federico, B. A. Youngblood, Memphis, United States WS.B4.02.06 Mitochondrial morphological and funcional reprogramming following CD137 (4-1BB) co- simulaion I. Etxeberria, S. Labiano, S. Garasa, E. Santamaría, A. Rouzaut, M. Enamorado, A. Azpilikueta, S. Inoges, E. Bolaños, M. Aznar, A. Sánchez-Paulete, D. Sancho, I. Melero, A. Teijeira, Pamplona, Spain WS.B1.05 Ani-tumor immunology 8:30 - 9:45 G104-105 Chairpersons: Ludovic Marinet, France & Aideen Ryan, Ireland WS.B1.05.01 Dissecing the immune heterogeneity of neuroblastoma microenviroment in murine models to develop novel therapeuic strategies for high-risk neuroblastoma paients V. Lucarini, O. Melaiu, M. Vinci, M. Compagnone, G. Ziccheddu, L. Cifaldi, V. Pistoia, D. Fruci, Rome, Italy WS.B1.05.02 Deiciency of host CD96 and PD-1 or TIGIT enhances tumor immunity without signiicantly compromising immune homeostasis H. Harjunpaa, S. J. Blake, E. Ahern, S. Allen, J. Liu, J. Yan, V. Lutzky, K. Takeda, A. Roman Aguilera, C. Guillerey, D. Mital, X. Y. Li, W. C. Dougall, M. J. Smyth, M. W. Teng, Brisbane, Australia WS.B1.05.03 Stromal Protein βig-h3 Reprograms Tumor Microenvironment in Pancreaic Cancer D. Goehrig, J. Nigri, R. Samain, Z. Wu, C. Paola, G. Gabiane, X. Zhang, Y. Zhao, I. Kim, M.

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 80 Wednesday, September 5th, 2018 ECI2018

Chanal, R. Curto, V. Hervieu, C. de la Fouchardière, F. Novelli, P. Milani, R. Tomasini, C. Bousquet, P. Bertolino, A. Hennino, Lyon, France WS.B1.05.04 Retargeing T cells against leukemia by lipid-speciic TCR transfer M. Consonni, C. Garavaglia, C. de Lalla, A. Bigi, A. Mancino, M. Casucci, A. Bondanza, M. Lepore, L. Mori, G. De Libero, F. Ciceri, P. Dellabona, G. Casorai, Milano, Italy WS.B1.05.05 Chorioallantoic membrane model to study glycan dependent tumor growth and difereniaion N. M. Sahasrabudhe, L. Cornelissen, K. Castricum, J. van der Horst, V. L. Thijssen, S. J. van Vliet, Amsterdam, Netherlands WS.B1.05.06 An NK cell-driven inlammatory switch regulated by cyclooxygenase-2 acivity restricts tumor growth and predicts cancer paient outcome E. Bonavita, V. S. Pelly, C. Bromley, E. Flanagan, S. Sahoo, H. Leong, S. Zelenay, Manchester, United Kingdom WS.B1.06 Ani-tumor strategies 12:00 - 13:15 G102-103 Chairpersons: Alexandre Corthay, Norway & Milada Sirova, Czech Republic WS.B1.06.01 Revisiing the role of type 1 convenional dendriic cells (cDC1) in cancer immunosurveillance and in responses to immunotherapies against cancer R. Maiuz, J. Cancel, L. Pouyet, F. Romagné, N. Bendriss-Vermare, C. Caux, J. Valladeau- Guilemond, M. Dalod, K. Crozat, Marseille, France WS.B1.06.02 Generaion of Memory Stem T cells speciic for tumor anigens and resistant to inhibitory signals by genome ediing B. C. Ciancioi, A. Potenza, Z. Magnani, V. Vavassori, P. Genovese, L. Naldini, E. Ruggiero, C. Bonini, Milan, Italy WS.B1.06.03 A CD3xCD19 bispeciic DART®molecule induces T-cell mediated killing of CLL cells in vitro A. W. J. Martens, S. R. Janssen, L. Izhak, A. P. Kater, G. J. van der Windt, Amsterdam, Netherlands WS.B1.06.04 MDM2-targeing as a new Natural Killer cell-based immunotherapy of neuroblastoma I. Veneziani, E. Ferrei, D. Fruci, L. Moreta, V. Pistoia, F. Locatelli, L. Cifaldi, Rome, Italy WS.B1.06.05 Mutated NPM1 as target for immunotherapy of acute myeloid leukemia D. I. van der Lee, R. M. Reijmers, M. W. Honders, R. S. Hagedoorn, R. M. de Jong, M. G. Kester, D. M. van der Steen, A. H. de Ru, H. M. Bijen, C. Kweekel, I. Jedema, H. Veelken, M. H. Heemskerk, P. A. van Veelen, F. J. Falkenburg, M. Griioen, Leiden, Netherlands WS.B1.06.06 Enhanced immunogenicity of mitochondrial localised mutated proteins in cancer cells G. Prota, U. Gileadi, M. Rei, A. Lechuga Vieco, J. Chen, J. Rehwinkel, A. Ahmed, J. Enríquez, V. Cerundolo, Oxford, United Kingdom WS.B3.02 T cell mediated immune regulaion in tumors 13:45 - 15:00 G102-103 Chairpersons: Jun Wang, China & Sabine Hoepner, Switzerland WS.B3.02.01 HDAC7 controls CD8+ T cell dependent ani-tumor immunity C. Yerinde, J. Keye, F. Schmidt, B. Siegmund, R. Glauben, C. Weidinger, Berlin, Germany WS.B3.02.02 Deciphering the molecular pathways underlying oncogenic IL-7R signaling in T-cell acute lymphoblasic leukemia A. Murcia Ceballos, P. Fuentes Villarejo, S. González García, M. García Peydró, J. Alcain, E. García Marínez, A. A. Ferrando, M. Toribio, Madrid, Spain WS.B3.02.03 Epithelial signals promote local efector Foxp3+ regulatory T cell accumulaion in the gut A. Bremser, H. Meinicke, A. Izcue, Aachen, Germany WS.B3.02.04 Intravital signaling visualizaion reveals that transient producive interacions between T regulatory cells and classical DC support cancer immune tolerance F. Marangoni, E. Carrizosa, V. Mani, M. Thelen, J. Prüssmann, T. R. Mempel, Charlestown, United States WS.B3.02.05 The CD58-CD2 axis controls killing of leukemic B cells by cytotoxic T lymphocytes V. Zurli, T. Montecchi, G. Wimmer, O. Acuto, C. Baldari, A. Kabanova, Siena, Italy WS.B3.02.06 Funcional ani-TIGIT anibodies modulate T cell responses in vivo K. O. Dixon, M. Schorer, J. Nevin, Y. Etminan, Z. Amoozgar, T. Kondo, S. Kurtulus, N. Kassam, R. A. Sobel, D. Fukumura, R. K. Jain, A. C. Anderson, V. K. Kuchroo, N. Joller, Zurich, Switzerland WS.B3.03 T cell responses in health and disease 13:45 - 15:00 G104-105 Chairpersons: Richard Duggleby, United Kingdom & Chrisina Helbig, The Netherlands

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WS.B3.03.01 Loss of NIK in thymic epithelial cells leads to fatal autoimmunity through aberrant Treg development C. Hatmann, F. Mair, E. Terskikh, M. Spalinger, B. P. Leung, A. Waisman, B. Becher, Zürich, Switzerland WS.B3.03.02 A Timer for analyzing temporally dynamic changes in transcripion during T cell difereniaion in vivo D. Bending, P. Prieto Marín, A. Paduraru, C. Ducker, E. Marzaganov, M. Laviron, T. Crompton, M. Ono, London, United Kingdom WS.B3.03.03 A temporally dynamic Foxp3 autoregulatory transcripional circuit controls the efector Treg programme D. Bending, A. Paduraru, C. Ducker, P. Prieto Marin, T. Crompton, M. Ono, Birmingham, United Kingdom WS.B3.03.04 N4BP1 and TNIP1 control MHC-1 display on neuroblastoma tumors L. Spel, J. Nieuwenhuis, R. Haarsma, E. Sickel, O. Bleijerveld, M. Altelaar, j. Boelens, T. Brummelkamp, S. Nierkens, M. Boes, Utrecht, The Netherlands WS.B3.03.05 T cell-induced tumor vulnerability discovery in anIFNg-independent genomic landscape D. Peeper, D. Vredevoogd, Amsterdam, The Netherlands WS.B3.03.06 NKG2A blockade poteniates CD8+ T-cell immunity induced by cancer vaccines T. van Hall, N. van Monfoort, L. Borst, M. J. Korrer, Y. Kim, S. Santegoets, M. Welters, P. Andre, S. Piersma, S. H. van der Burg, Leiden, The Netherlands Symposia and Workshops Track C S.C5 Allergy, asthma and therapy 8:30 - 9:45 Auditorium Chairpersons: Clare Lloyd, United Kingdom & Rudolf Valenta, Austria S.C5.01 Spontaneous protein crystallizaion in asthma: A new pathway for intervenion Bart Lambrecht, Belgium S.C5.02 Isotype-speciic regulaion of BCR signal transducion Jürgen Wienands, Germany S.C5.03 Geneic restricion of anigen-presentaion dictates allergic sensiizaion and disease in humanized mice Winfried Pickl, Austria S.C6 Innate control of inlammaion and issue repair 13:45 - 15:00 Elicium Chairpersons: Véronique Witko-Sarsat, France & Zsolt Szepfalusi, Austria S.C6.01 The yin yang of phagocyte regulaion and inlammatory cytokines Alberto Mantovani, Italy S.C6.02 Extracellular DNA traps: Neutrophils, eosinophils, basophils Hans-Uwe Simon, Switzerland S.C6.03 Mitochondrial failure in monocytes immunocompromise the NLRP3 inlammasome in human sepsis Pablo Pelegrin Vivancos, Spain WS.C1.03 Cytokine and transcripion factor mediated immune regulaion 8:30 - 9:45 E104-107 Chairpersons: Tamara Saksida, Serbia & Chrisina Zielinski, Germany WS.C1.03.01 Ani-TNF treatment leads to delayed acivaion, maturaion and proliferaion of CD4+ T cells but does not confer a global suppressive phenotype G. A. M. Povoleri, S. Lalnunhlimi, K. Steel, S. Agrawal, M. Ridley, S. Kordasi, C. Roberts, L. S. Taams, London, United Kingdom WS.C1.03.02 Vγ6+ γδ17 T cells home to the male reproducive tract and expand at puberty to keep pathogens at bay H. Brigas, A. Wilharm, I. Sandrock, T. Amado, T. Carvalho, A. Reinhardt, B. Silva-Santos, I. Prinz, J. Ribot, Lisboa, Portugal WS.C1.03.03 IL-27 increases the plasicity of difereniated Th17 cells by inducing IL-12R beta2 expression A. Awasthi, V. K. Kuchroo, Faridabad, India WS.C1.03.04 TGF-β bioacivity in Trichuris muris homogenate induces FOXP3+ T regulatory cells and inhibits Th1 and Th2 polarisaion when acivated

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A. E. Ogunkanbi, B. Eldakhakhny, J. L. Pennock, Manchester, United Kingdom WS.C1.03.05 Hobit ideniies precursors of resident memory T cells within the peripheral issues L. Parga Vidal, F. Behr, N. Kragten, T. Wesselink, R. Stark, K. van Gisbergen, Amsterdam, Netherlands WS.C1.03.06 EOMES-posiive CD4+T cells are increased in PTPN22 (1858T) risk allele carriers K. Chemin, D. Ramsköld, L. Diaz-Gallo, J. Herrath, M. Houtman, K. Tandre, L. Rönnblom, V. Malmström, Stockholm, Sweden WS.C1.04 Regulaion in issue speciic autoimmunity 2 8:30 - 9:45 G106-107 Chairpersons: Vivianne Malmström, Sweden & Alexandros Sarantopoulos, Greece WS.C1.04.01 Th17.1 cells preferenially recruit to the central nervous system to mediate early disease acivity in muliple sclerosis J. van Langelaar, R. M. van der Vuurst de Vries, M. Janssen, A. F. Wierenga-Wolf, I. M. Spilt, T. A. Siepman, W. Dankers, G. M. Verjans, H. E. de Vries, E. Lubberts, R. Q. Hintzen, M. M. van Luijn, Roterdam, Netherlands WS.C1.04.02 4-1BB overexpression in basal kerainocytes induces the disrupion of the eye´s immune privilege E. Gonnelli, M. Kasper, V. Kupas, D. Bauer, T. A. Luger, A. Heiligenhaus, K. Loser, Münster, Germany WS.C1.04.03 Targeing CD146 can downregulate new blood vessel formaion caused by VEGF-producing T cells in rat experimental autoimmune uveiis G. Wildner, M. Diedrichs-Möhring, S. Thurau, Munich, Germany WS.C1.04.04 Persistence of dominant TCRâ clones in regulatory T cells derived from an autoimmune inlammatory environment G. Mijnheer, J. Leong, A. Boltjes, E. Spierings, A. Petrelli, S. Vastert, S. Albani, A. Pandit, F. van Wijk, Utrecht, Netherlands WS.C1.04.05 Characterizaion of consituively DC-deicient mice in autoimmune responses C. Hilpert, D. Voehringer, Erlangen, Germany WS.C1.04.06 Engineering anigen-expressing regulatory T cells to modulate adverse immune responses D. W. Scot, M. Abdeladhim, A. Zhang, J. H. Yoon, K. Parvathaneni, L. Kropp, Y. C. Kim, E. Mitre, Bethesda, United States WS.C2.03 Pathophysiology of autoimmune diseases 12:00 - 13:15 Forum Chairpersons: Ricardo Pujol-Borrell, Spain & Lucy Walker, United Kingdom WS.C2.03.01 Cholesterol metabolism drives the funcion of regulatory B cells J. Bibby, A. Cope, E. Perucha, London, United Kingdom WS.C2.03.02 Neutrophil acivaion and altered coagulaion in a rat model for autoimmune hemolyic anemia L. Del Vasto Nunez, G. van Mierlo, I. Jongerius, B. M. Luken, N. Jufermans, S. Zeerleder, Amsterdam, Netherlands WS.C2.03.03 JMJD3/UTX histone H3K27 demethylases regulate metabolic and inlammatory Th17 cell funcion in ankylosing spondyliis A. P. Cribbs, M. Philpot, R. K. Prinjha, P. Wordsworth, P. Bowness, M. Feldmann, U. Oppermann, Oxford, United Kingdom WS.C2.03.04 Immunoglobulin A acivated myeloid cells induce pathological osteoclast acivaion in rheumatoid arthriis paients M. M. J. van Gool, A. C. Breedveld, R. E. Mebius, M. van Egmond, Amsterdam, Netherlands WS.C2.03.05 Ani-Ly9 (CD229) anibody treatment reduces marginal zone B cell numbers and salivary gland inlammaion in a mouse model of Sjögren’s Syndrome J. Puñet-Oriz, M. Sáez Moya, M. Cuenca, A. Lázaro, J. Boix Nebot, P. Engel, Barcelona, Spain WS.C2.03.06 Dysregulated expression of RasGRP1 in T cells leads to autoimmunity T. Douma, D. Simeonov, D. Myers, M. Baars, G. Mijnheer, F. van Wijk, A. Marson, J. Roose, Y. Vercoulen, Utrecht, Netherlands WS.C6.03 Immune cells in issue ibrosis 12:00 - 13:15 E104-107 Chairpersons: Amiram Ariel, Israel & Heinfried Radeke, Germany WS.C6.03.01 Plasmacytoid dendriic cells promote lung and skin ibrosis R. R. Singh, S. Kafaja, A. Divekar, R. Saggar, F. Abin, D. Khanna, D. Furst, I. Valera, Los Angeles, United States 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 83 Wednesday, September 5th, 2018 ECI2018

WS.C6.03.02 S100A8/A9 promotes parenchymal damage and renal ibrosis in obstrucive nephropathy A. Tammaro, Amsterdam, Netherlands WS.C6.03.03 CXCL4 drives inlammaion and ibrosis on monocyte-derived dendriic cells through transcripional and epigeneic imprining S. C. Silva-Cardoso, W. Tao, C. Angiolilli, A. Lopes, C. Bekker, J. van Laar, E. Hack, R. de Boer, M. Boes, A. Pandit, T. Radstake, Utrecht, Netherlands WS.C6.03.04 Liver sinusoidal endothelial cells trigger CD8 T cell mediated liver failure and herald liver regeneraion M. Luedemann, A. Gorol, L. A. D’Alessandro, S. Donakonda, U. Klingmueller, P. A. Knolle, Munich, Germany WS.C6.03.05 NLRP3- A key in the mediaion of coliis into coliis-associated colorectal cancer A. P. Perera, R. Eri, Launceston, Australia WS.C6.03.06 The IgE-FcεR1 axis strongly promotes epithelial hyperplasia and inlammaion-driven skin carcinogenesis M. Hayes, S. Ward, L. Wang, R. Castro Seoane, G. Crawford, J. Strid, London, United Kingdom WS.C3.02 T regulatory cells derived and other cellular therapies in transplantaion 12:00 - 13:15 G104-105 Chairpersons: Makota Miyara, France & Giovanni Povoleri, United Kingdom WS.C3.02.01 Development of a novel protocol to produce massive amounts of autologous thymus-derived Treg cells (thyTreg) to be employed as cellular therapy in transplanted children. A new paradigm in the treatment of immunological diseases E. Bernaldo de Quirós, V. Pérez, M. Clemente, J. Gil-Jaurena, M. Fernández-Santos, S. Suárez, V. Plasencia, A. Acosta, M. Camino, N. Gil, E. Panadero, C. Medrano, M. Pion, R. Correa-Rocha, Madrid, Spain WS.C3.02.02 Efecive Treg therapy of lethal acute grat-versus-host disease C. Riegel, T. Böld, E. Huber, P. Hofmann, M. Edinger, Regensburg, Germany WS.C3.02.03 Re-direcing Treg speciicity toward allograt transplants to sustainably prevent rejecion R. Alhamawi, C. Dempsey, R. Albugami, S. Lee, N. D. Jones, Birmingham, United Kingdom WS.C3.02.04 Extracellular adenosine reversibly inhibits the acivaion of human regulatory T cells and negaively inluences the achievement of the operaional tolerance in liver transplantaion A. Baroja-Mazo, B. Revilla-Nuin, L. Marínez-Alarcón, J. Herrero, A. El-Tayeb, C. Müller, P. Aparicio, P. Pelegrín, J. Pons, El Palmar Murcia, Spain WS.C3.02.05 Targeing recipient anigen presening cells with sialic acid- modiied alloanigen to promote transplantaion tolerance M. Sen, K. Ratnasothy, M. Ambrosini, D. Guiliano, Y. van Kooyk, G. Lombardi, L. A. Smyth, London, United Kingdom WS.C3.02.06 Third party virus-speciic T-cells for treatment of viral reacivaions in immune compromised paients and risks of allo-HLA cross-reacivity W. Huisman, D. A. Leboux, L. Hageman, D. Amsen, F. J. Falkenburg, I. Jedema, Amsterdam, Netherlands WS.C2.04 Therapy of autoimmune disorders 13:45 - 15:00 E104-107 Chairpersons: William van Eden, The Netherlands & Piotr Trzonkowski, Poland WS.C2.04.01 Funcional reprogramming of regulatory T cells in the absence of Foxp3 L. M. Charbonnier, Y. Cui, D. Lopez, J. J. Bleesing, M. I. Garcia-Lloret, K. Chen, A. Ozen, M. O. Li, T. A. Chaila, Boston, United States WS.C2.04.02 Immune response proiling reveals signaling networks mediaing TNF-blocker funcion and predictors of therapeuic responses in spondyloarthriis paients S. Menegai, V. Rouilly, E. Lais, H. Yahia, E. Mascia, C. Leloup, D. Dufy, A. Urruia, E. Achouri, L. Quintana-Murci, M. Albert, C. Miceli, M. Dougados, E. Bianchi, L. Rogge, Paris, France WS.C2.04.03 Targeing NF-κB signalling in B cells: a potenial new treatment modality for anibody mediated autoimmune diseases J. P. van Hamburg, P. Tuijnenburg, B. Helder, L. van Keep, K. Wesenhagen, P. Kucharzewka, M. H. Jansen, A. Al-Soudi, P. L. Klarenbeek, H. Olsson, N. de Vries, T. W. Kuijpers, S. W. Tas, Amsterdam, Netherlands WS.C2.04.04 Suppression of autoreacive T and B lymphocytes by selecive therapy in humanized murine SCID model of systemic lupus erythematosus 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 84 Wednesday, September 5th, 2018 ECI2018

S. Bradyanova, N. Mihaylova, P. Chipinski, E. Ivanova-Todorova, D. Kyurkchiev, M. Herbáth, J. Prechl, A. I. Tchorbanov, Soia, Bulgaria WS.C2.04.05 Interleukin-6 Receptor inhibiion, as irst-line b-DMARD, afects B cell subpopulaions distribuion through epigeneic modiicaions in Rheumatoid Arthriis paients C. Di Mario, B. Tolusso, S. Alivernini, A. Fedele, L. Petricca, M. Gigante, G. Ferraccioli, E. Gremese, Rome, Italy WS.C2.04.06 Co-engaging CD47 and CD19 with a bispeciic anibody impairs B cell proliferaion induced by B-cell receptor cross-linking E. Haterer, L. Barba, N. Noraz, B. Daubeuf, J. Aubry-Lachainaye, B. van der Weid, F. Richard, W. Ferlin, M. Kosco-Vilbois, V. Buatois, L. Shang, Geneva, Switzerland Symposia and Workshops Track D S.D4 Exploiing host pathogen interacion 12:00 - 13:15 Auditorium Chairpersons: Jaap van Dissel, The Netherlands & Gary Entrican, United Kingdom S.D4.01 Immune suppression by Salmonella David Holden, United Kingdom S.D4.02 Immune deviaions in virus-induced asthma Nikos Papadopoulous, Greece S.D4.03 Microbial regulaion of innate immunity and homeostasis Kathy McCoy, Canada WS.D3.02 Novel vaccine approaches for viruses 8:30 - 9:45 G102-103 Chairpersons: Sarah Gilbert, United Kingdom & Paul Parren, The Netherlands WS.D3.02.01 Deciphering the complexity of vaccine-induced immunity with omics technologies: innate immune responses difer between priming and boosing immunizaion J. L. Palgen, N. Tchitchek, J. Elhmouzi-Younes, S. Delandre, I. Namet, N. Huot, P. Rosenbaum, N. Dereuddre-Bosquet, F. Marinon, A. Cosma, M. Müller-Trutwin, Y. Lévy, R. Le Grand, A. S. Beignon, Fontenay-aux-Roses, France WS.D3.02.02 Ideniicaion of vaccine responding T-cells using TCR repertoire sequencing data M. V. Pogorelyy, A. A. Minervina, M. Puelma Touzel, E. A. Komech, E. I. Kovalenko, G. G. Karganova, E. S. Egorov, A. Y. Komkov, D. M. Chudakov, I. Z. Mamedov, T. Mora, A. M. Walczak, Y. B. Lebedev, Moscow, Russian Federaion WS.D3.02.03 Mucosal vaccine mediates cross-protecion by immune training P. Brandi, L. Conejero, F. Cueto, S. Marinez-Cano, P. Saz-Leal, M. Enamorado, J. Amores-Iniesta, J. Subiza, D. Sancho, Madrid, Spain WS.D3.02.04 Liver-resident memory CD8 T cells develop during chronic viral infecion, have reduced efector funcions but can be reacivated to clear persistent viral infecion of hepatocytes M. Bosch, K. Manske, S. Donakonda, D. Wohlleber, P. A. Knolle, N. Kallin, Munich, Germany WS.D3.02.05 Harnessing T-helper (Th) cell responses induced by licensed vaccines for HIV vaccine development H. Elsayed, G. Nabi, W. J. Mckinstry, M. Tenbusch, V. Temchura, K. Überla, Erlangen, Germany WS.D3.02.06 Design of TLR2 ligand-syntheic long pepide conjugates for therapeuic vaccinaion of chronic HBV paients Y. Dou, D. T. S. Jansen, A. van den Bosch, R. A. de Man, N. van Monfoort, G. G. Zom, W. Krebber, C. J. Melief, A. M. Woltman, S. I. Buschow, Roterdam, Netherland WS.D4.07 Innate immune responses and infecion 8:30 - 9:45 E102 Chairpersons: Ilse Jongerius, The Netherlands & Gabriele Pradel, Germany WS.D4.07.01 Primary neutrophil defects reveal the mechanisms of neutrophil extracellular trap (NET) formaion and NETosis: a unique role for acive cytoskeletal rearrangments E. Sprenkeler, A. Tool, T. K. van den Berg, T. Kuijpers, Amsterdam, The Netherlands WS.D4.07.02 Characterizaion of neutrophils generated in vitro from Hoxb8-transduced myeloid progenitor cells A. Orosz, A. Mócsai, Budapest, Hungary WS.D4.07.03 Regnase-3 is an essenial RNase for the Interferon pathway in issue macrophages M. Von Gamm, A. Schaub, J. Lichi, M. Tschöp, V. Hornung, C. Schulz, M. Heikenwälder, E. Glasmacher, Munich, Germany 5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 85 Wednesday, September 5th, 2018 ECI2018

WS.D4.07.04 A viral immunoevasin controls innate immunity by targeing the prototypical natural killer cell receptor family O. Aguliar, R. Berry, M. Rahim, J. Reichel, B. Popovic, M. Tanaka, Z. Fu, G. Balaji, T. Lau, M. Tu, C. Kirkham, A. Mahmoud, A. Mesci, A. Krmpoic, D. Allan, A. Makrigiannis, S. Jonjic, J. Rossjohn, J. Carlyle, Clayton, Australia WS.D4.07.05 Intracellular lifestyle of the probioic bacteria Lactobacillus plantarum; implicaions for its extraintesinal disseminaion A. Pellon, E. Atondo, M. Montesinos-Polledo, M. A. Pascual-Itoiz, A. Peña-Cearra, A. Carreras- Gonzalez, S. Varona-Fernandez, J. M. Landete, J. M. Rodriguez, R. Prados-Rosales, L. Abecia, J. L. Lavin, J. Anguita, H. Rodriguez, Derio, Spain WS.D4.07.06 Nanovaccines to prevent listeriosis in the elderly C. Alvarez-Dominguez, R. Calderon-Gonzalez, H. Teran-Navarro, D. Salcines-Cuevas, M. Fresno- Escudero, Santander, Spain WS.D1.02 Innate responses and immune signaling 12:00 - 13:15 G106-107 Chairpersons: James Doonan, United Kingdom & Chrisian Bauer, Germany WS.D1.02.01 The microbiota protects against respiratory infecion via GM-CSF signaling T. B. Clarke, R. L. Brown, R. P. Sequeira, London, United Kingdom WS.D1.02.02 Hypercholesterolemia afects macrophage metabolism and funcion J. Baardman, M. van Weeghel, S. Verberk, K. H. Prange, M. P. de Winther, J. Van den Bossche, Amsterdam, Netherlands WS.D1.02.03 MR1 recogniion by human γδ T cells J. Le Nours, N. Gherardin, S. Ramarathinam, W. Awad, B. Gully, R. Berry, F. Wiede, D. Fairlie, T. Tiganis, J. McCluskey, D. Pellicci, A. Uldrich, A. Purcell, D. Godfrey, J. Rossjohn, Clayton, Australia WS.D1.02.04 RNA helicase DDX3 is a potent inducer of type I interferon and adapive immunity M. Stunnenberg, S. I. Gringhuis, T. B. Geijtenbeek, Amsterdam, Netherlands WS.D1.02.05 Recruitment of DC-SIGN+ monocyte-derived dendriic cells in the skin for anigen delivery and adapive immunity S. T. Scheters, L. J. Kruijssen, M. H. Crommentuijn, J. den Haan, Y. van Kooyk, Amsterdam, Netherlands WS.D1.02.06 Enhanced trained immunity by targeing SHIP-1 in myeloid cells P. Saz-Leal, C. del Fresno, P. Brandi, S. Marínez-Cano, O. M. Dungan, J. D. Chisholm, W. G. Kerr, D. Sancho, Madrid, Spain WS.D1.03 Regulaion of efector Immune responses 13:45 - 15:00 Forum Chairpersons: Hyun-Dong Chang, Germany & Frits Koning, The Netherlands WS.D1.03.01 Intesinal dysbiosis driven by dietary trp deprivaion limits myelin-reacive T cell responses in a murine muliple sclerosis model J. K. Sonner, M. Keil, M. Falk-Paulsen, R. Bhari, N. Mishra, M. Kramer, K. Deumelandt, L. Wolf, I. Oezen, T. V. Lanz, I. Brandao, F. Wanke, Y. Tang, J. G. Okun, F. Kurschus, C. Reinhardt, W. Wick, P. Rosensiel, M. Platen, Heidelberg, Germany WS.D1.03.02 Gut dysbiosis induces dendriic-cell traic from colon to pancreaic lymph node: implicaions for acivaion of islet-reacive T cells in type 1 diabetes R. Toivonen, S. Silojärvi, S. Pöysi, E. Yatkin, A. Takeda, M. Miyasaka, A. Hänninen, Turku, Finland WS.D1.03.03 Imaging mass cytometry reveals the microanatomical locaion of B cell subsets in human gut associated lymphoid issue T. Tull, K. Todd, N. Petrov, R. Ellis, S. Heck, M. Bemark, J. Spencer, London, United Kingdom WS.D1.03.04 De novo faty acid synthesis during mycobacterial infecion is a prerequisite for the funcion of highly proliferaive T cells, but not for dendriic cells or macrophages L. Berod, P. Stueve, L. Minarrieta, C. Hölscher, T. Sparwasser, Hannover, Germany WS.D1.03.05 Cuing and pasing in the immunoproteome of infected cells C. van Els, J. van Gaans-van den Brink, J. Liepe, H. Meiring, M. Mishto, A. Plateel, M. Poelen, A. Sijts, Utrecht, Netherlands WS.D1.03.06 Funcional bias of efector memory CD8 T cells underlies the pathogenesis of Hepaiis E Virus in the elderly J. Gouilly, F. Abravanel, E. Bahraoui, N. Jabrane-Ferrat, J. Izopet, H. El Costa, Toulouse, France

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 86 Wednesday, September 5th, 2018 ECI2018

Symposia Track E S.E3 From single cells to populaion dynamics 8:30 - 9:45 Elicium Chairpersons: Frits Koning, The Netherlands & Valenina Proserpio, Italy S.E3.01 Human innate lymphoid cells in health and disease Jenny Mjösberg, Sweden S.E3.02 Characterizaion of T cell responses by single cell in vivo fate mapping Dirk Busch, Germany S.E3.03 Standardized muli-parametric immune proiling to predict outcome of inlammatory diseases Birgit Sawitzki, Germany S.E4 Cell communicaion and signaling in the immune system 13:45 - 15:00 Auditorium Chairpersons: Francisco Sanchez-Madrid, Spain & Odmund Bakke, Norway S.E4.01 Common and disinct Immune funcions of exosomes and other extracellular vesicles Cloilde Thery, France S.E4.02 Flexibility in immune synapse compartmentalisaion changes set point for T cell responses Michael Dusin, United Kingdom S.E4.03 Metabolic programs controlling immune cell funcion Tim Sparwasser, Germany Closing and Awards Ceremony CC.01 Closing and Awards Ceremony 16:45-17:30 Elicium

CC.01.01 Recap of the meeing Janneke Samsom, LOC President ECI2018 & Chrisina Helbig, EFIS/ECI2018 President‘s Oice CC.01.02 EFIS-Biolegend Bright Sparks Awards (see also p. 13) Winfried Pickl, EFIS treasurer & Gene Lay, CEO Biolegend CC.01.03 Poster Awards (see also p. 13) Sjaak Neejes, SPC President ECI2018 CC.01.04 ECI2021(see also p. 100) Günnur Deniz, President ECI2021 CC.01.05 Closing Words Marieke van Ham, Congress President ECI2018

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 87 Wednesday, September 5th, 2018 ECI2018 Poster Sessions, Wednesday, September 5th, 2018 Track A – Immune development and differentiation P.A2.03 Immune development and aging from the cradle to the grave - Part 3 P.A2.04 Immune development and aging from the cradle to the grave - Part 4 P.A3.06 Immunomonitoring and biomarkers - Part 6 P.A3.07 Immunomonitoring and biomarkers - Part 7 P.A4.03 Germinal centers and B cell difereniaion - Part 3 P.A5.05 Iniiaion of immune responses - Part 5 P.A5.06 Iniiaion of immune responses - Part 6 P.A5.07 Iniiaion of immune responses - Part 7 Track B – Tumor immunology and therapy P.B1.06 Tumor vaccinaion principles and Immunotherapy - Part 6 P.B1.07 Tumor vaccinaion principles and Immunotherapy - Part 7 P.B1.08 Tumor vaccinaion principles and Immunotherapy - Part 8 P.B2.06 Environmental regulaion ani-tumor responses - Part 6 P.B2.07 Environmental regulaion ani-tumor responses - Part 7 P.B3.04 T-cell regulaion - Part 4 P.B4.03 T-cell acivaion and exhausion - Part 3 Track C – Autoimmunity, Allergy and Transplantation P.C1.06 Maintenance and local regulaion of issue speciic immunity - Part 6 P.C1.07 Maintenance and local regulaion of issue speciic immunity - Part 7 P.C1.08 Maintenance and local regulaion of issue speciic immunity - Part 8 P.C2.08 Immune signaling and therapy in autoimmunity - Part 8 P.C2.09 Immune signaling and therapy in autoimmunity - Part 9 P.C2.10 Immune signaling and therapy in autoimmunity - Part 10 P.C2.11 Immune signaling and therapy in autoimmunity - Part 11 P.C3.03 Organ Transplantaion, Genotyping P.C3.04 MHC, Stem Cell Trnasplantaion and Regulaion P.C4.03 Manipulaion of tolerance - Part 3 P.C5.03 Allergy, asthma and therapy - Part 3 P.C6.05 Innate control of inlammaion and issue repair - Part 5 P.C6.06 Innate control of inlammaion and issue repair - Part 6 Track D – Infections and microbial immune regulation P.D1.04 Microbiome, metabolites and the immune system - Part 4 P.D2.02 NK cells and innate immune mechanisms P.D3.04 Novel approaches to vaccinology - Part 4 P.D4.07 Exploiing host pathogen interacion - Part 7 P.D4.08 Exploiing host pathogen interacion - Part 8 P.D4.09 Exploiing host pathogen interacion - Part 9 P.D4.10 Exploiing host pathogen interacion - Part 10 P.D4.11 Exploiing host pathogen interacion - Part 11 Track E – Technical advances and big data P.E4.01 Cell communicaion and signaling in the immune system

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 88 ECI2018 IUIS Advertisement

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5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 89 ECI2018 Industry Sponsored Symposia, Sponsoring and Exhibition This secion contains informaion that is promoional in nature, disinct from the scieniic/educaional elements of the congress.

Table of Content

Acknowledgements p. 90 Company Descripions p. 92 Industry Sponsored Symposia p. 94 Progress in Technology Session p. 94 Exhibiion Informaion p. 95 Exhibiion Floor Plan p. 96 Exhibitors (A-Z) p. 47

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 90 ECI2018 Acknowledgements ECI wishes to thank the following main sponsors for their support of ECI2018: Platinum Sponsor

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5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 91 ECI2018 Biolegend Advertisement

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GSK is one of the world’s leading vaccine companies, with a porfolio of vaccines for infants, adolescents and adults and 14 candidate vaccines in development.

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 93 ECI2018 DAREBeckman Coulter Advertisement TO EXPLORE YOUR TRUE COLOR with CytoFLEX LX

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5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL * Alexa Fluor and Paciic Blue are registered trademarks of Molecular Probes, Inc. 94 ECI2018 Industry Sponsored Symposia Monday, September 3rd, 2018 IS.01 Industry Sponsored Lunch Symposium: Biolegend and 10X Genomics 13:15 - 14:30 G106-107 Simultaneous Proteomics and Transcriptomics - the future of single cell analysis Applying the newest single-cell technology on the oldest immune cell known to man Marin Guilliams, Belgium Introducion to TotalSeqTM Kristopher Nazor, United States Introducion to 10x Genomics Stephen Hague, United Kingdom

IS.02 Industry Sponsored Lunch Symposium: Beckman Coulter 13:15 - 14:30 G102-103 Cytometry Innovaion Slam: Speed-up your set-up!

Stepping stones to high content cytometry: Extended DURAClone IM panels provide stunning insights into viral infecions and immunity Andrea Cossarizza, Italy Unsupervised analysis needs supervised noise: How spreading and background noise impact your R/esults Jolanda Brummelmann, Italy Phenotyping and funcional characterizaion of immune cells peripheral blood and in the tumor microenvironment Eda Holl, United Kingdom Elusive extracellular vesicles and how luorescence low cytometry can catch them. Nicolas Arraud, Switzerland

IS.03 Industry Sponsored Progress in Technology Session: Stemcell Technologies 18:00 - 19:00 E102 T Cell Difereniaion and Cancer Immunity

T Cell Difereniaion and Cancer Immunity Bruno Silva-Santos, Portugal Tools for Immunology Research Graeme Milton, France Tuesday, September 4th, 2018 IS.04 Industry Sponsored Lunch Symposium: Fluidigm 13:15 - 14:30 G102-103 Visualize a New Path Forward: Mass Cytometry and Imaging Mass Cytometry for Translaional Immune System Research A brief introducion to Mass Cytometry ® Amy Hamilton, The Netherlands Advancing human systems immunology Peter Brodin, Sweden Analysis of the human mucosal immune system by Mass Cytometry reveals issue and disease-associated immune signatures Frits Koning, The Netherlands

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 95 ECI2018 Exhibition Information The exhibiion is an important component of the ECI congress, providing paricipants with an ideal plaform to network with industry partners in the ield and an opportunity to gain further insights into the newest advancement from the industry side. 59 companies and publishers are exhibiing at the ECI 2018 congress. The technical exhibiion takes place in hall 10 on the irst loor. Please see ‚Exhibiion Floor Plan‘ on p. 96 and further details on ‚„Exhibitors (A-Z)“ op pagina 97 on p. 97. Exhibition & Society Village - opening hours: Monday, September 3, 2018 9:30 - 19:30 Tuesday, September 4, 2018 9:30 - 19:30 Wednesday, September 5, 2018 9:00 - 12:30 Exhibitor Service Desk Exhibitor badges and complimentary congress badges are available for pick-up at the Exhibitor Service Desk in the entrance hall. Exhibitor badges are to be used solely for staf members of the exhibiing companies and only allow access to the exhibiion hall. The complimentary congress registraions allow access to the scieniic sessions and receipt of the congress bag. These are also to be used solely by staf members of the exhibiing companies, as they will not show a barcode on the badge, hence will not abtain any CME credits. Tickets to visit only the exhibiion are not available. Opening hours Saturday, September 1, 2018 8:00 - 22:00 Sunday, September 2, 2018 8:00 - 22:00 Monday, September 3, 2018 8:00 - 19:30 Tuesday, September 4, 2018 8:00 - 19:30 Wednesday, September 5, 2018 8:00 - 22:00 Exhibitor access Exhibitors may enter the exhibiion area one hour prior to the oicial opening and must leave the exhibiion halls at the latest 30 minutes ater closing. Meeings or customer events on the booth area before 9:30 and ater 19:30 (on Wednesday 12:30) are not allowed.

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 96 ECI2018 Exhibition Floor Plan

E Rooms Curry MoCa € Delta Cafe & Burgers Sandwiches Co ee Co ee / Tea P. Track D Track P. E Track P. Auditorium 41 42 38 39 40 37 36 32 31 35 34 33 26 27 28 29 30 24 25 Best Posters Area Best Posters 23 22 21 20 19 50 49 17 18 15 16 14 64 59 60 61 13 12 11 10 51 i 52 58 57 66 63 62 06 07 05 08 09 Help Desk Posters 45 45a 46 47 48 52a Posters Track C Track Posters 68 67 55 56 44 Elicium 53 43 04 03 02 01 69 54 Registration Area Registration 71 72 70 73 Co ee Co ee / Tea Lunch bags Lunch HALL 10 Toilets Posters Track B Track Posters Posters Track A Track Posters € € Lunch bags Lunch Co ee Co ee / Tea Co ee Co ee / Tea Dutch Pancakes Dutch Sushi Time Sushi Time Piaggo HALL 11

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 97 ECI2018 Exhibitors (A-Z) The following companies are exhibiing at the ECI 2018 (as per August 2018)

Exhibitors Company Name Booth Number Company Name Booth Number 10x Genomics Inc. 09 IBA GmbH 35 Abbvie 01 Immudex 16 Abcam 38 Invitalis 23 Absolute Anibody 49 InvivoGen SAS 51 ACEA Biosciences, Inc. 15 Jackson ImmunoResearch Europe Ltd 26 Adapive Biotechnologies Corp 34 JPT Pepide Technologies GmbH 10 Agilent Technologies 52a KDBIO 62 AID GmbH 32 Logos Biosystems 63 AYOXXA Biosystems 29 Luminex BV 06 Beckman Coulter GmbH 02 Mabtech AB 21 BECTON DICKINSON EUROPE SAS 50 MERCK 37 BioLegend UK Ltd. 08 MILTENYI BIOTEC GmbH 04 Bio-Rad Laboratories 42 Nicoya Lifesciences Inc. 31 Bio-Techne 05 OriGene Technologies 48 Bio X Cell 58 PEPperPRINT GmbH 64 Brand Insitute, Inc. 36 PeproTech EC Ltd. 18 Caltag Medsystems Ltd 19 pepides&elephants GmbH 45a Cell Signaling Technology 14 ProImmune Ltd. 27 Charles River 17 Quanterix 22 ChemoMetec 20 Randox Biosciences 28 Cloud-Clone Corp. 11 RMS Medical Products 72 CTL Europe GmbH 46 Sanquin 13 Cyagen US Inc. 52 Sartorius 39 CYTOGNOS, S.L. 59 Sino Biological 58 DIACLONE SAS 60 Sony Europe Ltd. 03 Exbio Praha, a.s. 47 STEMCELL TECHNOLOGIES SARL 24 FlowJo 30 Takara Bio Europe SAS 40 Fluidigm 12 Thermo Fisher Scieniic 07 Froniers in Immunology 71 University of Bonn - University Hospital 61 HEALTH IN CODE, S.L. 41 Wiley 33 Hycult Biotechnology BV 25 WISEPRESS LTD 70 Society Village Society Booth Number American Associaion Immunologists (AAI) 69 Austrian Society for Allergology and Immunology (ÖGAI) 55 Briish Society for Immunology (BSI) 54 Dutch Society for Immunology (NVVI) 73 European Federaion of Immunological Socieies (EFIS) 45 French Society of Immunology (SFI) 56 Georgian Associaion of Allergology and Clinical Immunology (GAACI) 57 German Society for Immunology (DGfI) 43 Internaional Union of Immunological Socieies (IUIS) 68 Italian Society of Immunology (SIICA) 53 Irish Society for Immunology (ISI) 67 Scandinavian Society for Immunology (SSI) 66 Turkish Society of Immunology (TSI) 44

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5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 101 ECI2018 Networking Events

Welcome Reception Sunday, September 2, 2018 at 19:00 RAI Amsterdam, Auditorium We are pleased to invite you to our Welcome Recepion that will take place just ater the Opening Ceremony, staring at 19:00. There you can catch up with colleagues and meet new ones. You will be able to get a taste of very diverse and wonderful Dutch tradiions while being surrounded by an internaional atmosphere. We are looking forward to an interacive, delighful & mulicultural evening! The Welcome Recepion is free of charge; however admission is only possible for registered paricipants. No sponsoring is used to fund any part of the evening. ECI Networking Evening Tuesday, September 4, 2018 at 20:00 Strandzuid The Networking Event is a great opportunity to meet with colleagues from around the world in a relaxed atmosphere and enjoy a ime together by Amsterdam's famous grachten (canals). Those who have shared this evening with us in previous years know, one would not want to miss it. Price per Person: EUR 60.00 Limited availability! Dinner and three drinks are included in the price. The event is enirely at the paricipants’ own expenses. No sponsoring is used to fund any part of the evening.

Strandzuid

L C D K Metro Entrance RAI Metro

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 102 ECI2018 The City of Amsterdam Amsterdam is located in the western Netherlands, in the province of North Holland. Known to many for its canals and bicycles, it is a city of cyclists, and to a visitor it may even seem like there are more bicycles than people. Amsterdam has had a strong tradiion as a centre of culture and commerce and with world-class museums and theatre, to laid-back bars and wonderful restaurants, there's never a shortage of things to do in Amsterdam. For further informaion on what Amsterdam has to ofer, please visit The Amsterdam City Portal website at: www.iamsterdam.com. The website ofers a wide variety of things to do whilst in Amsterdam and provides informaion on the local area. Time zone (CEST) Amsterdam is 6 hours ahead of US - EDT, and 1 hour ahead of GMT. Climate Amsterdam has a moderate, mariime climate largely inluenced by the North Sea and other surrounding waterways. Warm summer air and cold winter chills arrive quite gradually. Early September, temperatures in Amsterdam range from 12°C (53.6°F) to 21°C (69.8°F) on average. Rainfall occurs on about 120 days annually and is spread evenly throughout the year. Electricity The power supply in the Netherlands is 220/240 V. Most electric outlets adhere to the coninental standard (Schuko). Appliances from North America require a transformer and Briish ones an adaptor for the two-pin sockets in use in the Netherlands. Museums The Netherlands’ capital city has been a centre of creaivity and culture for centuries. Works by 17th century Dutch Masters such as Rembrandt and Vermeer grace the walls of Amsterdam’s famous Rijksmuseum. The Van Gogh Museum houses several of the arists’ masterpieces. Other cultural treasures include Anne Frank’s House, the baroque Royal Palace on Dam Square and the Rembrandt House. Amsterdam can even saisfy the cultural pallet of the most experienced visitor. Churches, Synagogues, Mosques In Amsterdam all religions are allowed and praciced by many ciizens. Historical churches and places of worship of diferent religions in the Old City of Amsterdam cerify to the city’s mulicultural tradiions. Please contact your hotel concierge for current imes of services or nearby churches. Restaurants & Nightlife Amsterdam is home to an array of bars, nightclubs and cafés. Authenic 19th century pubs or ‘brown cafés can be found all over the city, alongside their contemporary counterparts: designer grand cafés and sleek lounge bars. The most popular bar areas are around the Leidseplein and Rembrandtplein. There are also jazz cafés, late night bars and a large casino in the city. Best of all, nightlife venues are located less than a few square miles of each other.

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 103 ECI2018

On the restaurant front, Amsterdam is ofering a culinary meling pot relecive of the city itself. City restaurants ofer everything a hungry visitor craves: from Indonesian to tapas, from Mediterranean to modern Dutch. Air Travel to Amsterdam Amsterdam Schiphol Airport is the primary internaional airport in the Netherlands. It is located about 20 kilometres south-west of Amsterdam. Schiphol is a naional and internaional airport with ninety airlines ofering nonstop lights travelling to 260 desinaions worldwide. Many smaller airlines also ly to regional airports such as Roterdam or Eindhoven. From these, you can travel via public transport or taxi to Amsterdam. To travel to and from Eindhoven Airport to Amsterdam you can use the Air Express Bus. Transport from Schiphol Airport Amsterdam has an extensive public transport network, with trams, buses, ferries and the Metro all serving the city and surrounding suburbs. You can reach the city from Schiphol in just half an hour by train, taxi or hotel shutle. The Connexxion Schiphol Hotel Shutle links the airport with almost every hotel in Amsterdam. Every day, shutles run from 06:30-21:00 and you will never have to wait from more than 30 minutes for the next departure. Single ickets cost EUR 17,50, return ickets EUR 28,00. Schiphol train staion is located directly underneath the airport with an average of 5 trains an hour to Amsterdam Central Staion. Train ickets are available at the icket oice in the airport's main hall and from the yellow icket machines which are located near the baggage claims, shopping centre Schiphol Plaza and near the plaforms. These machines accept European cash cards (MAESTRO), and some also accept coins, but not credit cards. The taxi rank is located at the airport’s exit. Depending on traic, a taxi can take you to the city centre in half an hour. One ride will cost you approximately 40 euros. It is strongly advised not to take rides from drivers soliciing within the airport. These are not oicially approved taxi drivers. Public Transportation Travelling within Amsterdam is straight-forward and convenient. The extensive public transport network connects the city's many districts by train, tram, metro, bus and ferry. In Amsterdam and beyond, the public transport chip card (OV-chipkaart) is used for travel on trams, buses and metros. The most convenient opions for visitors are one-hour cards, (muli) day cards, or an anonymous card which you can add more credit to at any ime. Travel info on www.9292.nl/en. Renting a bicycle You won't have to be long in Amsterdam to realise that biking is an integral part of the Dutch lifestyle. Rening a bike is a great way to explore the hidden gems of Amsterdam or also one of the many opions how to get to the conference locaion. Bike rental costs about 10 euros a day. View our list of bike rental locaions in Amsterdam for more informaion: htps://www.iamsterdam.com/en/plan-your-trip/geing-around/rental/bike-hire

5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL 104 ECI2018

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5th European Congress of Immunology, September 2-5, 2018, Amsterdam, NL