Reviewing Threats to Wild Rhodiola Sachalinensis, a Medicinally Valuable Yet Vulnerable Species
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Download free from www.wjtcm.net Review Article Reviewing Threats to Wild Rhodiola sachalinensis, A Medicinally Valuable yet Vulnerable Species Josef A. Brinckmanna, Anthony B. Cunninghamb,c, David E. V. Harterd aTraditional Medicinals, Sustainability Department, 4515 Ross Road, Sebastopol, California, 95472, USA, bSchool of Life Sciences, University of KwaZulu‑Natal, King Edward Avenue, Pietermaritzburg, 3209, South Africa, cSchool of Veterinary and Life Sciences, Murdoch University, 90 South St., Murdoch, WA, 6150, Australia, dBundesamt für Naturschutz (BfN), Konstantinstr. 110, Bonn, 53179, Germany Abstract Occurring in China, DPR Korea, Japan, and Russian Federation and classified in the Red List of Chinese Flora as a vulnerable species, Rhodiola sachalinensis Boriss. is used increasingly in cosmetics, dietary supplements, and Traditional Chinese Medicines (TCMs). The aim of this study was to evaluate the (i) conservation status, harvesting and trade levels of R. sachalinensis, (ii) current state of experimental and commercial farming, and (iii) evidence of substitution or interchangeable use of R. sachalinensis with other Rhodiola species. We assessed data from multiple disciplines and languages including studies on R. sachalinensis biology and ecology, information on impacts of wild harvest, management measures, and current levels of cultivation. Our assessment shows that while R. sachalinensis is increasingly produced by cultivation, wild populations are decreasing and face multiple threats. These include (a) habitat loss including due to oil and gas infrastructure development on Sakhalin island, (b) climate change impacts on alpine ecosystems, and (c) overexploitation of wild plants to satisfy the growing commercial demand. Assessments of the conservation status of R. sachalinensis should commence in each Range State, as well as resource assessments and monitoring of harvesting and trade of wild R. sachalinensis. Even with increased reliance on cultivation, biodiversity conservation, and genetic diversity in wild populations are relevant to future use of this species. Keywords: Conservation, Rhodiola rosea ssp. sachalinensis, Rhodiola sachalinensis, sustainable production, Traditional Chinese Medicine INTRODUCTION measures, and on the current level of cultivation. Our data collection strategy involved using a group of search terms in Rhodiola sachalinensis Borissova, Crassulaceae multiple languages (Chinese, English, Japanese, Korean, and (“gaoshanhongjingtian” (高山红景天), high mountain rhodiola Russian). Search terms included R. sachalinensis, traditional or “kuyehongjingtian” (库页红景天), Sakhalin rhodiola), is a medicine, wild collection, cultivation, export trade, harvesting, rare species with a fragmented distribution[1] in China, DPR conservation status, protected, threatened, red list, and red Korea, Russian Federation, and Japan.[2] R. sachalinensis has book. We used the online academic search engine Google become a popular Rhodiola species[3] traded in Traditional Scholar, China Academic Journals (CNKI) database, and Chinese Medicine (TCM) markets[4] and is also widely used ResearchGate, a professional network for scientists and in dietary supplements[5] and cosmetics. However, there are researchers, as well as patent databases of the China National conservation concerns about this vulnerable (VU) species.[6,7] Intellectual Property Administration, Korean Intellectual This study evaluates the (i) conservation status, harvesting, and trade in R. sachalinensis, (ii) current cultivation, and Address for correspondence: Prof. Josef A. Brinckmann, (iii) evidence of interchangeable use of R. sachalinensis with Traditional Medicinals, Sustainability Department, 4515 Ross Road, other Rhodiola species. Sebastopol, California 95472, USA. E‑mail: [email protected] METHODS This is an open access journal, and articles are distributed under the terms of the Creative We reviewed published studies on R. sachalinensis biology and Commons Attribution‑NonCommercial‑ShareAlike 4.0 License, which allows others to remix, ecology, information on impacts of wild harvest, management tweak, and build upon the work non‑commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. Access this article online For reprints contact: [email protected] Quick Response Code: © 2021 World Journal of Traditional Chinese Medicine | Published by Wolters Kluwer ‑ Medknow Website: www.wjtcm.net Received: 16-02-2021, Accepted: 31-03-2021, Published: 09-08-2021 DOI: How to cite this article: Brinckmann JA, Cunningham AB, V. Harter DE. 10.4103/wjtcm.wjtcm_47_21 Reviewing threats to wild Rhodiola sachalinensis, a medicinally valuable yet vulnerable species. World J Tradit Chin Med 2021;7:299-306. World J Tradit Chin Med | Volume 7 | Issue 3 | July-September 2021 299 Brinckmann, et al. Reviewing threats to wild Rhodiola sachalinensis Property Office, United States Patent and Trademark Office, differences between R. sachalinensis and R. rosea are and World Intellectual Property Organization. For information described. Third, while R. rosea has a circumpolar distribution, on R. sachalinensis occurrence, conservation, legal, and R. sachalinensis has a much more limited geographic regulatory status, we searched the websites and databases of distribution in Northeast China, DPR Korea, small parts of governmental organizations such as ministries of agriculture, Japan, and the Russian Far East. environment, health, medicines, natural resources and ecology, Chemistry and medicinal uses and tourism, respectively. The root and rhizome of R. sachalinensis contain phenylpropanoids such as the cinnamyl alcohol glycosides RESULTS rosarin and rosavin, the phenylethanoid compound salidroside Taxonomy with its aglycone tyrosol, flavonols such as rhodionin While “The Plant List”, Version 1.1. (2013) treats R. sachalinensis and rhodiosin,[14] monoterpene glycosides (sachalosides I Borissova as a synonym of Sedum roseum (L.) Scop,[8] and the and II), flavonol bisdesmosides (sachalosides III and IV), International Crassulaceae Network lists R. sachalinensis and cyanogenic glycosides (sachaloside V).[15] The Jilin Borissova, Sedum sachalinense (Borissova) Voroschilov, and provincial standards for TCM materials require the herbal Rhodiola rosea ssp. sachalinensis (Borissova) S. Gontcharova drug “Rhodiolae Sachalinensis Radix et Rhizoma” to contain as synonyms of R. rosea L.,[9] Chinese authorities on botany, not-less-than (NLT) 0.20% of salidroside and NLT 0.020% of [16] taxonomy, threatened species, and TCM treat R. sachalinensis tyrosol, calculated on a dried drug basis. Less specifically, as a distinct article; for example, botanists at Flora of China,[2] the Zhejiang provincial standards for TCM materials require and at the Ministry of Environmental Protection and Chinese pharmacopoeial quality R. sachalinensis to contain NLT 22.0% [17] Academy of Sciences (Red List of Chinese Flora),[6] as extractive matter and NLT 6.0% total rhodiola glycosides. well as pharmacognosists at provincial TCM drug product According to TCM theory, R. sachalinensis root and rhizome administrations. Regardless of some differing taxonomic acts to invigorate qi and promote blood circulation and is opinions, in China, R. rosea and R. sachalinensis are classified indicated for treating conditions such as qi deficiency and blood and traded as separate articles of commerce, sourced from stasis, chest pain, angina, stroke, hemiplegia (paralysis of one [16] separate geographic origins, R. rosea from Xinjiang and side of the body), fatigue, asthma, and panting. R. sachalinensis from Jilin and Heilongjiang, each with distinct Ecology and distribution characteristics described in monographs. As we reported The habitat of R. sachalinensis is described as forested slopes, [10] earlier in Cunningham et al., we treat R. sachalinensis as gravel slopes, and alpine tundra in northeastern China (Jilin, a distinct species for three reasons. First, chemotaxonomic Heilongjiang), DPR Korea, Russian Federation, and Japan,[2] [11] [12] studies by Booker et al. and Liu et al., show chemical as well as in rock crevices and stony sites on some volcanic differences between R. rosea (collected in Xinjiang) and oceanic islands of Japan and the Russian Federation.[18] R. sachalinensis (collected in Heilongjiang and Liaoning). While the observed differences in Liu et al.,[12] using a high performance In China, R. sachalinensis is distributed mainly in the liquid chromatography-diode array detection and ultraviolet Changbai Mountain Range of northeastern Jilin province spectrophotometric (HPLC-DAD/UV) method, based on [Figure 1], and Heilongjiang province in the Zhangguangcai [19] [20] eight compounds of four chemical classes (phenylpropanoids, Mountains and Daxingan Mountains. It is found, in phenylethanol derivatives, flavonoids, and phenolic acids) the Yanbian Korean Autonomous Prefecture of China’s [21] were only weak, Booker et al.,[11] using general metabolomic Jilin Province, which borders both Primorsky Territory, fingerprinting but also specific high‑performance thin‑layer Far Eastern Federal District, Russian Federation, as chromatography (HPTLC) methods for testing of the rosavin well as the northernmost province of DPR Korea, North and salidroside marker spectra, found compelling differences Hamgyong Province. In the Changbai Mountains Nature between R. rosea and R. sachalinensis samples. In a DNA Reserve (CMNR), R. sachalinensis is recorded