Existential Realities of Post Agriculture
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Franck-Hertz Experiment
IIA2 Modul Atomic/Nuclear Physics Franck-Hertz Experiment This experiment by JAMES FRANCK and GUSTAV LUDWIG HERTZ from 1914 (Nobel Prize 1926) is one of the most impressive comparisons in the search for quantum theory: it shows a very simple arrangement in the existence of discrete stationary energy states of the electrons in the atoms. ÜÔ ÖÑÒØ Á Á¾ ¹ ÜÔ ÖÑÒØ This experiment by JAMES FRANCK and GUSTAV LUDWIG HERTZ from 1914 (Nobel Prize 1926) is one of the most impressive comparisons in the search for quantum theory: it shows a very simple arrangement in the existence of discrete stationary energy states of the electrons in the atoms. c AP, Department of Physics, University of Basel, September 2016 1.1 Preliminary Questions • Explain the FRANCK-HERTZ experiment in our own words. • What is the meaning of the unit eV and how is it defined? • Which experiment can verify the 1. excitation energy as well? • Why is an anode used in the tube? Why is the current not measured directly at the grid? 1.2 Theory 1.2.1 Light emission and absorption in the atom There has always been the question of the microscopic nature of matter, which is a key object of physical research. An important experimental approach in the "world of atoms "is the study of light absorption and emission of light from matter, that the accidental investigation of the spectral distribution of light absorbed or emitted by a particular substance. The strange phenomenon was observed (first from FRAUNHOFER with the spectrum of sunlight), and was unexplained until the beginning of this century when it finally appeared: • If light is a continuous spectrum (for example, incandescent light) through a gas of a particular type of atom, and subsequently , the spectrum is observed, it is found that the light is very special, atom dependent wavelengths have been absorbed by the gas and therefore, the spectrum is absent. -
CV Otto Diels
Curriculum Vitae Prof. Dr. Otto P. H. Diels Name: Otto Paul Hermann Diels Lebensdaten: 23. Januar 1876 – 7. März 1954 Otto Diels war ein deutscher Chemiker. Für die auch nach ihm benannte Diels‐Alder‐Reaktion (auch Diensynthese genannt) erhielt er 1950 gemeinsam mit seinem Schüler Kurt Alder den Nobelpreis für Chemie. Gemeinsam mit Emil Abderhalden arbeitete er über Gallensteine und begann, sich mit Cholesterin zu beschäftigen. Darüber hinaus trägt die Diels‐Säure seinen Namen, eine von ihm bei der Strukturaufklärung der Steroide synthetisierte Dicarbonsäure. Akademischer und beruflicher Werdegang Otto Diels studierte ab 1895 an der Universität Berlin die Fächer Chemie, Physik, Botanik, Mineralogie und Philosophie. Er wurde im Sommer 1899 beim späteren Nobelpreisträger für Chemie, Emil Fischer, mit einer Arbeit über Cyanur‐Verbindungen promoviert. Im selben Jahr wurde er Assistent am Chemischen Institut der Universität Berlin. 1904 folgte die Habilitation. 1913 wurde er im selben Institut Abteilungsvorsteher. 1914 wurde er an der Universität Berlin zum außerordentlichen Professor ernannt. Zwei Jahre später nahm er einen Ruf nach Kiel an. Dort wurde er Professor für Chemie und Direktor des Chemischen Instituts und fungierte im akademischen Jahr 1925/26 als Rektor der Kieler Universität. Er blieb seiner Alma mater bis an sein Lebensende treu, trotz mehrfacher Berufungen an andere Hochschulen, darunter nach Gießen und Berlin. Nobelpreis für Chemie 1950 Bereits 1911 begann Diels, den Azodicarbonsäurediethylester zu untersuchen. Diese kurz „Azoester“ genannte Verbindung führte ihn schließlich zu seinem wichtigsten Arbeitsgebiet, der Untersuchung der Dien‐Synthese, wie die Reaktion eines Diens mit einem reaktiven Alken oder Alkin zunächst genannt wurde. Einzelne Experimente, die Diels schließlich als Dien‐Synthesen erkannte, waren bereits kurz nach der Jahrhundertwende veröffentlicht worden. -
Warburg Effect(S)—A Biographical Sketch of Otto Warburg and His Impacts on Tumor Metabolism Angela M
Otto Cancer & Metabolism (2016) 4:5 DOI 10.1186/s40170-016-0145-9 REVIEW Open Access Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism Angela M. Otto Abstract Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are seminal to our present knowledge of metabolic and energetic processes in cells. Since science is a human endeavor, and a scientist is imbedded in a network of social and academic contacts, it is worth taking a glimpse into the biography of Otto Warburg to illustrate some of these influences and the historical landmarks in his life. His creative and innovative thinking and his experimental virtuosity set the framework for his scientific achievements, which were pioneering not only for cancer research. Here, I shall allude to the prestigious family background in imperial Germany; his relationships to Einstein, Meyerhof, Krebs, and other Nobel and notable scientists; his innovative technical developments and their applications in the advancement of biomedical sciences, including the manometer, tissue slicing, and cell cultivation. The latter were experimental prerequisites for the first metabolic measurements with tumor cells in the 1920s. In the 1930s–1940s, he improved spectrophotometry for chemical analysis and developed the optical tests for measuring activities of glycolytic enzymes. Warburg’s reputation brought him invitations to the USA and contacts with the Rockefeller Foundation; he received the Nobel Prize in 1931. -
The Nobel Prize Sweden.Se
Facts about Sweden: The Nobel Prize sweden.se The Nobel Prize – the award that captures the world’s attention The Nobel Prize is considered the most prestigious award in the world. Prize- winning discoveries include X-rays, radioactivity and penicillin. Peace Laureates include Nelson Mandela and the 14th Dalai Lama. Nobel Laureates in Literature, including Gabriel García Márquez and Doris Lessing, have thrilled readers with works such as 'One Hundred Years of Solitude' and 'The Grass is Singing'. Every year in early October, the world turns Nobel Day is 10 December. For the prize its gaze towards Sweden and Norway as the winners, it is the crowning point of a week Nobel Laureates are announced in Stockholm of speeches, conferences and receptions. and Oslo. Millions of people visit the website At the Nobel Prize Award Ceremony in of the Nobel Foundation during this time. Stockholm on that day, the Laureates in The Nobel Prize has been awarded to Physics, Chemistry, Physiology or Medicine, people and organisations every year since and Literature receive a medal from the 1901 (with a few exceptions such as during King of Sweden, as well as a diploma and The Nobel Banquet is World War II) for achievements in physics, a cash award. The ceremony is followed a magnificent party held chemistry, physiology or medicine, literature by a gala banquet. The Nobel Peace Prize at Stockholm City Hall. and peace. is awarded in Oslo the same day. Photo: Henrik Montgomery/TT Henrik Photo: Facts about Sweden: The Nobel Prize sweden.se Prize in Economic Sciences prize ceremonies. -
The Franck-Hertz Experiment: 100 Years Ago and Now
The Franck-Hertz experiment: 100 years ago and now A tribute to two great German scientists Zoltán Donkó1, Péter Magyar2, Ihor Korolov1 1 Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Budapest, Hungary 2 Physics Faculty, Roland Eötvös University, Budapest, Hungary Franck-Hertz experiment anno (~1914) The Nobel Prize in Physics 1925 was awarded jointly to James Franck and Gustav Ludwig Hertz "for their discovery of the laws governing the impact of an electron upon an atom" Anode current Primary experimental result 4.9 V nobelprize.org Elv: ! # " Accelerating voltage ! " Verh. Dtsch. Phys. Ges. 16: 457–467 (1914). Franck-Hertz experiment anno (~1914) The Nobel Prize in Physics 1925 was awarded jointly to James Franck and Gustav Ludwig Hertz "for their discovery of the laws governing the impact of an electron upon an atom" nobelprize.org Verh. Dtsch. Phys. Ges. 16: 457–467 (1914). Franck-Hertz experiment anno (~1914) “The electrons in Hg vapor experience only elastic collisions up to a critical velocity” “We show a method using which the critical velocity (i.e. the accelerating voltage) can be determined to an accuracy of 0.1 V; its value is 4.9 V.” “We show that the energy of the ray with 4.9 V corresponds to the energy quantum of the resonance transition of Hg (λ = 253.6 nm)” ((( “Part of the energy goes into excitation and part goes into ionization” ))) Important experimental evidence for the quantized nature of the atomic energy levels. The Franck-Hertz experiment: 100 years ago and now Franck-Hertz experiment: published in 1914, Nobel prize in 1925 Why is it interesting today as well? “Simple” explanation (“The electrons ....”) → description based on kinetic theory (Robson, Sigeneger, ...) Modern experiments Various gases (Hg, He, Ne, Ar) Modern experiment + kinetic description (develop an experiment that can be modeled accurately ...) → P. -
Bohr Model of Hydrogen
Chapter 3 Bohr model of hydrogen Figure 3.1: Democritus The atomic theory of matter has a long history, in some ways all the way back to the ancient Greeks (Democritus - ca. 400 BCE - suggested that all things are composed of indivisible \atoms"). From what we can observe, atoms have certain properties and behaviors, which can be summarized as follows: Atoms are small, with diameters on the order of 0:1 nm. Atoms are stable, they do not spontaneously break apart into smaller pieces or collapse. Atoms contain negatively charged electrons, but are electrically neutral. Atoms emit and absorb electromagnetic radiation. Any successful model of atoms must be capable of describing these observed properties. 1 (a) Isaac Newton (b) Joseph von Fraunhofer (c) Gustav Robert Kirch- hoff 3.1 Atomic spectra Even though the spectral nature of light is present in a rainbow, it was not until 1666 that Isaac Newton showed that white light from the sun is com- posed of a continuum of colors (frequencies). Newton introduced the term \spectrum" to describe this phenomenon. His method to measure the spec- trum of light consisted of a small aperture to define a point source of light, a lens to collimate this into a beam of light, a glass spectrum to disperse the colors and a screen on which to observe the resulting spectrum. This is indeed quite close to a modern spectrometer! Newton's analysis was the beginning of the science of spectroscopy (the study of the frequency distri- bution of light from different sources). The first observation of the discrete nature of emission and absorption from atomic systems was made by Joseph Fraunhofer in 1814. -
Sterns Lebensdaten Und Chronologie Seines Wirkens
Sterns Lebensdaten und Chronologie seines Wirkens Diese Chronologie von Otto Sterns Wirken basiert auf folgenden Quellen: 1. Otto Sterns selbst verfassten Lebensläufen, 2. Sterns Briefen und Sterns Publikationen, 3. Sterns Reisepässen 4. Sterns Züricher Interview 1961 5. Dokumenten der Hochschularchive (17.2.1888 bis 17.8.1969) 1888 Geb. 17.2.1888 als Otto Stern in Sohrau/Oberschlesien In allen Lebensläufen und Dokumenten findet man immer nur den VornamenOt- to. Im polizeilichen Führungszeugnis ausgestellt am 12.7.1912 vom königlichen Polizeipräsidium Abt. IV in Breslau wird bei Stern ebenfalls nur der Vorname Otto erwähnt. Nur im Emeritierungsdokument des Carnegie Institutes of Tech- nology wird ein zweiter Vorname Otto M. Stern erwähnt. Vater: Mühlenbesitzer Oskar Stern (*1850–1919) und Mutter Eugenie Stern geb. Rosenthal (*1863–1907) Nach Angabe von Diana Templeton-Killan, der Enkeltochter von Berta Kamm und somit Großnichte von Otto Stern (E-Mail vom 3.12.2015 an Horst Schmidt- Böcking) war Ottos Großvater Abraham Stern. Abraham hatte 5 Kinder mit seiner ersten Frau Nanni Freund. Nanni starb kurz nach der Geburt des fünften Kindes. Bald danach heiratete Abraham Berta Ben- der, mit der er 6 weitere Kinder hatte. Ottos Vater Oskar war das dritte Kind von Berta. Abraham und Nannis erstes Kind war Heinrich Stern (1833–1908). Heinrich hatte 4 Kinder. Das erste Kind war Richard Stern (1865–1911), der Toni Asch © Springer-Verlag GmbH Deutschland 2018 325 H. Schmidt-Böcking, A. Templeton, W. Trageser (Hrsg.), Otto Sterns gesammelte Briefe – Band 1, https://doi.org/10.1007/978-3-662-55735-8 326 Sterns Lebensdaten und Chronologie seines Wirkens heiratete. -
EMBO Facts & Figures
excellence in life sciences Reykjavik Helsinki Oslo Stockholm Tallinn EMBO facts & figures & EMBO facts Copenhagen Dublin Amsterdam Berlin Warsaw London Brussels Prague Luxembourg Paris Vienna Bratislava Budapest Bern Ljubljana Zagreb Rome Madrid Ankara Lisbon Athens Jerusalem EMBO facts & figures HIGHLIGHTS CONTACT EMBO & EMBC EMBO Long-Term Fellowships Five Advanced Fellows are selected (page ). Long-Term and Short-Term Fellowships are awarded. The Fellows’ EMBO Young Investigators Meeting is held in Heidelberg in June . EMBO Installation Grants New EMBO Members & EMBO elects new members (page ), selects Young EMBO Women in Science Young Investigators Investigators (page ) and eight Installation Grantees Gerlind Wallon EMBO Scientific Publications (page ). Programme Manager Bernd Pulverer S Maria Leptin Deputy Director Head A EMBO Science Policy Issues report on quotas in academia to assure gender balance. R EMBO Director + + A Conducts workshops on emerging biotechnologies and on H T cognitive genomics. Gives invited talks at US National Academy E IC of Sciences, International Summit on Human Genome Editing, I H 5 D MAN 201 O N Washington, DC.; World Congress on Research Integrity, Rio de A M Janeiro; International Scienti c Advisory Board for the Centre for Eilish Craddock IT 2 015 Mammalian Synthetic Biology, Edinburgh. Personal Assistant to EMBO Fellowships EMBO Scientific Publications EMBO Gold Medal Sarah Teichmann and Ido Amit receive the EMBO Gold the EMBO Director David del Álamo Thomas Lemberger Medal (page ). + Programme Manager Deputy Head EMBO Global Activities India and Singapore sign agreements to become EMBC Associate + + Member States. EMBO Courses & Workshops More than , participants from countries attend 6th scienti c events (page ); participants attend EMBO Laboratory Management Courses (page ); rst online course EMBO Courses & Workshops recorded in collaboration with iBiology. -
The Making of a Biochemist
book reviews disappearance of kuru as an important In the late 1920s, he looked into the effect TION episode in our understanding of the risks of light on the inhibition by carbon monox- A associated with this type of infectious ide of respiration in living cells. This work process. Informing the wider community of encompassed considerations of photo- these risks may lead to a more helpful debate chemical processes in terms of quantum about the public health policies required chemistry, and the use of the manometer, NOBEL FOUND to minimize the chances of another BSE photoelectric cell and spectroscope. From epidemic. Books such as this are useful in the shape of the curve obtained by plotting this context. the effectiveness of light against its wave- Colin L. Masters is in the Department of Pathology, length, it was possible to deduce the resem- 8 The University of Melbourne, Parkville, Victoria, blance between the respiratory ferment and 3052, Australia. haemins. Warburg was awarded the Nobel prize for physiology or medicine in 1931 for his recognition of the haemin-type nature of the respiratory ferment and its underlying The making principles. The development of Warburg’s theoreti- of a biochemist cal thinking and experimental procedures are Otto Warburgs Beitrag zur ably chronicled in Petra Werner’s introducto- Atmungstheorie: Das Problem der ry essay. Her book is the first volume of an Sauerstoffaktivierung* edition of Warburg’s correspondence Brilliant but flawed: Warburg tended to pettiness. by Petra Werner deposited in the Berlin–Brandenburg Aca- Basilisken-Presse: 1996. Pp. 390. DM136 demy of Sciences. Regrettably, the 143 pub- 1950). -
Nobel Prize Physicists Meet at Lindau
From 28 June to 2 July 1971 the German island town of Lindau in Nobel Prize Physicists Lake Constance close to the Austrian and Swiss borders was host to a gathering of illustrious men of meet at Lindau science when, for the 21st time, Nobel Laureates held their reunion there. The success of the first Lindau reunion (1951) of Nobel Prize win ners in medicine had inspired the organizers to invite the chemists and W. S. Newman the physicists in turn in subsequent years. After the first three-year cycle the United Kingdom, and an audience the dates of historical events. These it was decided to let students and of more than 500 from 8 countries deviations in the radiocarbon time young scientists also attend the daily filled the elegant Stadttheater. scale are due to changes in incident meetings so they could encounter The programme consisted of a num cosmic radiation (producing the these eminent men on an informal ber of lectures in the mornings, two carbon isotopes) brought about by and personal level. For the Nobel social functions, a platform dis variations in the geomagnetic field. Laureates too the Lindau gatherings cussion, an informal reunion between Thus chemistry may reveal man soon became an agreeable occasion students and Nobel Laureates and, kind’s remote past whereas its long for making or renewing acquain on the last day, the traditional term future could well be shaped by tances with their contemporaries, un steamer excursion on Lake Cons the developments mentioned by trammelled by the formalities of the tance to the island of Mainau belong Mössbauer, viz. -
A Nobel Synthesis
MILESTONES IN CHEMISTRY Ian Grayson A nobel synthesis IAN GRAYSON Evonik Degussa GmbH, Rodenbacher Chaussee 4, Hanau-Wolfgang, 63457, Germany he first Nobel Prize for chemistry was because it is a scientific challenge, as he awarded in 1901 (to Jacobus van’t Hoff). described in his Nobel lecture: “The synthesis T Up to 2010, the chemistry prize has been of brazilin would have no industrial value; awarded 102 times, to 160 laureates, of whom its biological importance is problematical, only four have been women (1). The most but it is worth while to attempt it for the prominent area for awarding the Nobel Prize sufficient reason that we have no idea how for chemistry has been in organic chemistry, in to accomplish the task” (4). which the Nobel committee includes natural Continuing the list of Nobel Laureates in products, synthesis, catalysis, and polymers. organic synthesis we arrive next at R. B. This amounts to 24 of the prizes. Reading the Woodward. Considered by many the greatest achievements of the earlier organic chemists organic chemist of the 20th century, he who were recipients of the prize, we see that devised syntheses of numerous natural they were drawn to synthesis by the structural Alfred Nobel, 1833-1896 products, including lysergic acid, quinine, analysis and characterisation of natural cortisone and strychnine (Figure 1). 6 compounds. In order to prove the structure conclusively, some In collaboration with Albert Eschenmoser, he achieved the synthesis, even if only a partial synthesis, had to be attempted. It is synthesis of vitamin B12, a mammoth task involving nearly 100 impressive to read of some of the structures which were deduced students and post-docs over many years. -
The Prime Cause, Prevention and Treatment of Cancer
International Science and Investigation Journal ISSN: 2251-8576 2016, 5(5) Journal homepage: www.isijournal.info The Prime Cause, Prevention and Treatment of Cancer Somayeh Zaminpira *1, Sorush Niknamian 2 *1 Ph.D. in Cellular and Molecular Biology, University of Cambridge, United Kingdom 2 Ph.D. in Cellular and Molecular Biology, University of Cambridge, United Kingdom 102 International Science and Investigation Journal Vol. 5(5) Abstract This meta-analysis research has gone through more than 200 studies from 1934 to 2016 to find the differences and similarities in cancer cells, mostly the cause. The most important difference between normal cells and cancer cells is how they respire. Normal cells use the sophisticated process of respiration to efficiently turn any kind of nutrient that is fat, carbohydrate or protein into high amounts of energy in the form of ATP. This process requires oxygen and breaks food down completely into harmless carbon dioxide and water. Cancer cells use a primitive process of fermentation to inefficiently turn either glucose from carbohydrates or the amino acid glutamine from protein into small quantities of energy in the form of ATP. This process does not require oxygen, and only partially breaks down food molecules into lactic acid and ammonia, which are toxic waste products. The most important result is that fatty acids or better told fats cannot be fermented by cells. This research mentions the role of ROS and inflammation in causing mitochondrial damage and answers the most important questions behind cancer cause and mentions some beneficial methods in preventing and treatment of cancer. Keywords Cancer, Respiration, Fermentation, ROS, Prevention Introduction 1.