Education Programs Overview Research Programs Overview Clinical Programs Overview Medicine by theNumbers Chairman’s Message Faculty Highlights Special Awards Organization 44 50 40 42 34 24 20 30 22 36 26 53 52 32 38 28 14 10 16 12 18 4 6 3 2 8 1 TABLE OF

Legacy Publications Committees Residents &Fellows Rheumatology Pulmonary/Critical Care Nephrology Infectious Diseases &Global Health Hospital Medicine Hematology/Oncology Geriatrics andPalliative Medicine Genetic Medicine General Internal Medicine Gastroenterology, Hepatology &Nutrition Endocrinology, Diabetes &Metabolism Emergency Medicine Dermatology Computational Biomedicine&Biomedical Data Science Cardiology CONTENTS CHAIRMAN’S MESSAGE entitled “Pushing theBoundaries ”. 2018 Department ofMedicineAnnual Report I amdelighted to present to you the cine. Ithankthemfor theirdedication to ourtripartite mission. who continue to pushtheboundaries ofwhatweknowinorder to achieve major advancements inmedi- I am proud to lead a Department that is comprised of outstanding clinicians, scientists and teachers to develop novel learning systems andprograms for ourtrainees andjuniorfaculty. tients ontheSouthSide. Withinourtraining programs educators intheDepartment ofMedicinecontinued department whichserves as theprimaryentrypointfor theinstitution’s newLevel 1Trauma Center for pa locations andcelebrated theopeningofcity ofChicago’s newest andmostadvanced adultemergency tion health. Relating to improved patient care, theDepartment expanded ourpresence atseveral offsite as examples of how the Department is pushing technology to advance medicine, outcomes andpopula for the treatment of celiac disease, asthma and IBD. Big data, machine learning, and telehealth also serve blood, prostate, head breast andneck, andlungcancers, anddeveloped innovative therapeutic strategies scientists. Medicineinvestigators translated discoveries into game changingimmunotherapies to fight to helpusfindinnovative ways to diagnose andtreat disease, andtrain thenext generation ofphysician by pushingourfundamental understanding ofsolutionsto improve patient care, drive scientificadvances This past academic year theDepartment ofMedicineachieved major successes inourtripartite mission Other notable departmental highlightsfrom thispast year include: • Increased grant fundingincludingtherenewal ofthree center grants: theComprehensive Cancer Center, Theappointmentofsixnew administrative• leaders: Yoav Gilad, PhD as Vice Chair for Research, Steven • National recognition as one of the safest hospitals in the country with the University of Chicago • National recognition for theworkofmany individuals includingdiabetes (Louis Philipson, MD, PhD ) • Recognition ofsixourfaculty withnamedprofessorships from theUniversity: Thomas Gajewski, MD, Leapfrog Group Medicine garnering straight A’s for the13thconsecutive timeby theprestigious andindependent the Institute for Translational MedicineandtheDiabetes Research &Training Center gency medicine(Teresita Hogan, MD) health disparities (Marshall Chin, MD), breast cancer (Olufunimilayo Olopade, MD)andgeriatric emer Louis Block Professor, andKeyoumars Soltani, MDas theAllan L.Lorincz Professor Diabetes Research &Care; Sonali Smith,MDas theElwood V. JensenProfessor; MDas NirUriel, the and Harold Lincoln ThompsonProfessor; Louis Philipson, MD, PhD as theJamesC.Tyree Professor in PhD as the AbbVie Foundation Professor of Cancer Immunotherapy; Bana Jabri, MD, PhD as the Sarah Committee Anne Sperling, PhD as Associate Vice Chair for Research and Julie Oyler, MD as Chair of the Women’s Geriatrics & Palliative Medicine, Diana Bolotin, MD, PhD as interim Chief of the Section of Dermatology, White, MDas Vice Chair for AppointmentsandPromotions, Stacie Levine, MDas Chief oftheSection - - -

Biological Sciences ofChicagoMedicine& University Physician-in-Chief, ofMedicine Chair, Department John E.UltmannProfessor Everett E.Vokes, MD 2018 Annual Report

1 By the Numbers Organization

Chairman, Department of Medicine Everett E. Vokes, MD Educational Activity Executive Vice Chair of Appointments & Promotions Steven White, MD* Committee: Vice Chair of Education John McConville, MD Vice Chair of Faculty Development Deborah Burnet, MD Trainees Vice Chair of Research Yoav Gilad, PhD 304 Bana Jabri, MD, PhD Julian Solway, MD 178 Residents Associate Vice Chair – Appointments & Promotions Dorothy Hanck, PhD* Subspecialty Associate Vice Chair – Ambulatory Operations Lisa Vinci, MD Subspecialty Fellows Associate Vice Chair – Quality Andrew Davis, MD Sections 126 Associate Vice Chair – Research Anne Sperling, PhD 15 Executive Administrator Julie J. White Associate Executive Administrator James Manthey

Section Cardiology James Liao, MD Chief Council: Computational Biomedicine & Biomedical Data Science Robert Grossman, PhD & Andrey Rzhetsky, PhD Dermatology Diana Bolotin, MD, PhD (interim) Emergency Medicine Linda Druelinger, MD Endocrinology, Diabetes & Metabolism Ronald Cohen, MD Gastroenterology, Hepatology & Nutrition David Rubin, MD Clinical Activity General Internal Medicine Deborah Burnet, MD Genetic Medicine Yoav Gilad, PhD Geriatrics and Palliative Medicine Stacie Levine, MD 14,326 Admissions Hematology/Oncology Walter Stadler, MD Hospital Medicine David Meltzer, MD, PhD 199,144 Onsite Visits Infectious Diseases & Global Health David Pitrak, MD Faculty Nephrology Arlene Chapman, MD Offsite Visits Pulmonary/Critical Care Gokhan Mutlu, MD 25,467 Rheumatology Marcus Clark, MD Emergency Room 317 63,552 Encounters Committee Diversity Committee Monica Vela, MD Chairs: Women’s Committee Julie Oyler, MD 1,174,805 RVU’s Chief 2018 Chief Residents Amrish Deshmukh, MD Residents: Abdul Dia, MD Michelle Fletcher, MD Research Activity Erica MacKenzie, MD

2019 Chief Residents Lauren Feld, MD Sarah Gray, MD #26 in NIH funding (2017) Marie McKinnon, MD Transplant David Tehrani, MD 325 Cases $83.3M Total NIH Awards Senior Budget and Finance Sunila Goel Clinical Trials Earnings Management: Clinical Revenue and Billing Lisa Kogan 141 $27.5M Clinical Research Support Allison Buonamici Bone Marrow Transplants 72 Clinical Trials Financial Group Ashley Hoambrecker Kidney Transplants $127M Total Sponsored Human Resources (Academic) Sharon Frazier 31 Heart Transplants Research Awards & Human Resources (Staff) Chris Yaros 26 Liver Transplants Clinical Trial Earnings Information Systems Max Marchevsky 23 Lung Transplants Research Administration Katie Pizer *New in FY19 ­ 28 CAR T-Cell 3 Pancreas Transplants 1 Kidney/Pancreas Transplants 2018 Annual Report 3 Special Awards 2018

Elected Fellows of the Elected Members of the American Academy of Arts and Sciences National Academy of Medicine Graeme Bell, PhD Graeme Bell, PhD Olufunmilayo Olopade, MD Marshall Chin, MD* Robert Gibbons, PhD Elected Members of the David Meltzer, MD, PhD Association of American Physicians Olufunmilayo Olopade, MD Michael A. Becker, MD Kenneth Polonsky, MD Eugene Chang, MD Arlene Chapman, MD American College of Physicians Masters Marcus Clark, MD Mark Siegler, MD Fredric Coe, MD Awards Alan Leff, MD Department of Medicine Named Professorships Bana Jabri, MD, PhD Graeme Bell, PhD – Kovler Family Distinguished Professor James Liao, MD Eugene Chang, MD – Martin Boyer Professor Distinguished Service Awards Leif B. Sorensen, MD, PhD Biological Sciences David Meltzer, MD, PhD Marshall Chin, MD – Richard Parillo Family Professor in Healthcare Ethics Joseph B. Kirsner, MD, PhD (2006) Faculty Research Award Division Awards Olufunmilayo Olopade, MD Thomas Gajewski, MD, PhD – AbbVie Foundation Professor+ Janet Rowley, MD (2007) Suzanne Conzen, MD ( 2007) BSD Distinguished Kenneth Polonsky, MD Robert Gibbons, PhD – Blum Riese Professor Louis Cohen, MD (2008) Marisa Alegre, MD, PhD (2008) Investigator Award – Jane Churpek, MD Mark J. Ratain, MD Harvey Golomb, MD – Lowell T. Coggeshall Professor Morton Arnsdorf, MD (2009) Anne Sperling, MD (2008) Distinguished Leader in Diversity Samuel Refetoff, MD Robert Grossman, PhD – Frederick H. Rawson Professor Angelo Scanu, MD (2010) Bana Jabri, MD, PhD (2009) and Inclusion – Karen Kim, MD Mark Siegler, MD Bana Jabri, MD, PhD – Sarah & Harold Lincoln Thompson Professor+ Keyoumars Soltani, MD (2011) Eric Svensson, MD, PhD (2010) & Rochelle Naylor, MD Julian Solway, MD James Liao, MD, PhD – Harold H. Hines, Jr. Professor Jesse B. Hall, MD (2013) Elbert Huang, MD (2011) Distinguished Clinician – Joyce Tang, MD Everett Vokes, MD Michelle Le Beau, PhD – Arthur and Marian Edelstein Professor Roy E. Weiss, MD, PhD (2014) Patrick Wilson, PhD (2012) Distinguished Leaders in Program Innovation – David Meltzer, MD, PhD – Fanny L. Pritzker Professor Mark Siegler, MD (2014) Konstantin Birukov, MD, PhD(2013) Roderick Tung, MD Elected Members of the Olufunmilayo Olopade, MD – Walter L. Palmer Distinguished Service Professor Samuel Refetoff, MD (2015) Lucy Godley, MD, PhD (2013) & Jonathan Paul, MD American Society for Clinical Investigation Louis Philipson, MD, PhD – James C. Tyree Professor in Diabetes Research & Care+ Eve Van Cauter, PhD (2016) John Schneider, MD, MPH (2014) Distinguished Leader in Community Marisa Alegre, MD, PhD Kenneth Polonsky, MD – Richard T. Crane Distinguished Service Professor Roberto Lang, MD (2017) Yu Ying He, PhD (2015) Service and Advocacy – Deborah Burnet, MD Vineet Arora, MD Nanduri Prabhakar, PhD – Harold H. Hines, Jr. Professor Dorothy Hanck, PhD (2017) Esra Tasali, MD (2016) & Shellie Williams, MD Michael A. Becker, MD Mark Ratain, MD – Leon O. Jacobson Professor Linda Druelinger, MD (2018) Monica Peek, MD (2017) Distinguished Educator/ Eugene Chang, MD Samuel Refetoff, MD – Frederick H. Rawson Professor Michelle Le Beau, PhD (2018) Yun Fang, PhD (2018) Mentor Award – Wei Wei Lee, MD Marcus Clark, MD David Rubin, MD – The Joseph B. Kirsner Professor of Medicine Fredric Coe, MD Andrey Rzhetsky, PhD – Edna K. Papazian Professor Arthur H. Rubenstein, MD Diversity Award Suzanne Conzen, MD Christopher Shea, MD – Eugene J. Van Scott Professor Mentorship Award Monica Vela, MD (2010) Elbert Huang, MD, MPH Mark Siegler, MD – Lindy Bergman Distinguished Service Professor Eugene B. Chang, MD (2007) David Howes, MD (2011) Thomas Gajewski, MD, PhD Keyoumars Soltani, MD – Allan L. Lorincz Professor++ Julian Solway, MD (2008) Blanca Camoretti-Mercado, PhD (2012) Lucy Godley, MD, PhD Sonali Smith, MD – Elwood V. Jensen Professor+ Jesse Hall, MD (2009) Minoli Perera, PhD (2013) Harvey Golomb, MD Julian Solway, MD – Walter L. Palmer Distinguished Service Professor Roberto Lang, MD (2010) Monica Peek, MD, MPH (2014) James Liao, MD Walter Stadler, MD – Fred C. Buffett Professor Marshall Chin, MD (2010) John Schneider, MD, MPH (2015) Alan Leff, MD Wendy Stock, MD – Anjuli Seth Nayak Professor in Leukemia Frederic Coe, MD (2011) James Woodruff, MD (2016) David Meltzer, MD, PhD Nir Uriel, MD – Louis Block Professor+ Olufunmilayo Olopade, MD (2012) Doriane Miller, MD (2017) Gokhan Mutlu, MD Eve Van Cauter, PhD – Frederick H. Rawson Professor Deborah Burnet, MD (2013) Milda Saunders, MD (2018) Olufunmilayo Olopade, MD Everett Vokes, MD – John E. Ultmann Professor Mary Strek, MD (2014) Kenneth Polonsky, MD Irving Waxman, MD – Sara and Harold Lincoln Thompson Professor David Meltzer, MD, PhD (2015) Samuel Refetoff, MD Wendy Stock, MD (2016) Julian Solway, MD Graeme Bell, PhD (2017) Everett Vokes, MD Vineet Arora, MD (2018)

+New in FY18 ++New in FY19 2018 Annual Report 5

Faculty Highlights

Vineet Arora, MD, is an academic hospitalist who Dr. Arora has also made major scientific contri- on matrixed learning experiences between nurses Lucy A. Godley, MD, PhD, is a physician-scientist studies educational and systems-based interven- butions to understanding sleep in hospitalized and residents, encouraging interdisciplinary collabo- focused on understanding the molecular pathways tions to improve quality, safety, and value of care patients. With funding from the National Insti- ration to reduce patient mortality, medication er- that drive carcinogenesis in the context of hema- delivered in academic teaching hospitals. She has tutes of Aging (NIA), she objectively documented rors, length of stay, and provider career satisfaction. topoietic malignancies. Dr. Godley is interested made significant contributions to the understanding clinically significant sleep loss in hospitalized in the germline genetic variants that elevate of how to improve the clinical learning environ- patients as compared to home, showed hospi- As Assistant Dean for Scholarship and Discovery for individual and family risk for developing cancers ment in academic teaching hospitals, particu- tal noise levels were as loud as a chainsaw at 15 the Pritzker School of Medicine (PSOM), Dr. Arora as well as the acquired genetic and epigenetic larly with respect to how to communicate during feet, and that hospital sleep loss is associated leads the required scholarly concentration program changes that accompany tumor formation. patient handoffs and resident sleep and fatigue. with both increased morning blood pressure and that has led to a 30% increase in publication higher odds of elevated blood glucose (“hyper- rates and is associated with increased interest in Dr. Godley began her scientific career in the labo- Lucy A. Godley, MD, PhD Dr. Arora is an internationally recognized expert glycemia of hospitalization”) among both diabetic research careers among Pritzker medical students. ratories of Drs. Sally and Vincent Marchesi at Yale Professor of Medicine in patient handoffs, having led the develop- and non-diabetic patients. She is the principal She also serves as principal investigator of the NIH/ University (1982-1985) and then as an undergrad- (Hematology/Oncology) and Human Genetics ment of guidelines for the Society of Hospital investigator of the NIH/NHLBI-funded SIESTA study NIA T35 grant focused on providing summer training uate at Harvard University under the guidance of Medicine and serving as an expert reviewer for (Sleep for Inpatients: Empowering Staff to Act), an in basic, clinical, and social science research for Dr. Don C. Wiley (1986-1988). During the graduate the creation of a National Handover Guideline interprofessional quality improvement initiative Pritzker medical students to inspire and pre- phase of her Medical Scientist Training Program for the Irish Health Ministry. She was the first to to improve sleep for hospitalized patients. pare them to pursue careers in aging research. (1988-1995), she conducted research under the describe how academic hospitals can standardize tutelage of Dr. Harold E. Varmus at the Universi- handoffs, one of 3 citations in the Accreditation Recently, Dr. Arora articulated a new model of bridg- A dedicated mentor and teacher, Dr. Arora has ty of California, San Francisco and the National Council of Graduate Medical Education’s (ACGME) ing leadership to align medical education and health impacted the education and training of dozens of Institutes of Health. Dr. Godley completed her Pathways to Excellence guide for U.S. academic system missions to engage trainees in interprofes- medical students, residents, fellows and junior medical training at Northwestern University (1996- teaching hospitals undergoing the new Clinical sional teams to improve care. She led the University faculty. She serves as the co-director for the 1997), followed by her internal medicine residency Learning Environment Review. With funding of Chicago as one of 3 institutions nationwide to MERITS (Medical Education Research Innovation training at The University of Chicago (1997-1999). As more than 1,000. These individuals serve as a vast myeloid cells with acquired mutations in epigene- from the Agency for Healthcare Research and receive the American Medical Association’s (AMA) Technology and Scholarship) fellowship program, a clinical hematology/oncology fellow (1999-2003), resource for discovery, already resulting in the tic genes, which is likely the first step to leukemia Quality, she developed and validated a tool to Accelerating Change in Medical Education and the mentoring fellows who have chosen to dedicate Dr. Godley conducted her postdoctoral research in publication of two new predisposition syndromes. development. Dr. Godley hopes that these insights measure handoff quality that is now the most ACGME Pursuing Excellence Initiative grants to trans- their careers to medical education research. She the laboratory of Dr. Michelle Le Beau, where she In addition, the laboratory is invested in ongoing can be used to develop new risk stratification used handoff tool worldwide. Her work objec- form clinical learning environments. In 2018, she was is the recipient of numerous mentoring awards focused her work on determining the molecular research into the pathophysiology of known genetic criteria for patients that will allow interventions tively studying the impact of night float and named a Macy Faculty Scholar by the Josiah Macy including a NIH K24 Mid-Career Mentoring Career basis for the abnormal DNA methylation patterns susceptibility syndromes. Dr. Godley serves as the to slow or even prevent leukemia development. workload on resident sleep and fatigue were the Foundation for her work to transform interprofes- Development Award, the Society of General Internal that characterize human tumors. As a member Co-Chair of the ClinGen Committee on Myeloid Pre- basis of testimony to the Institute of Medicine. sional clinical learning environments via her project Medicine’s inaugural Frederick L. Brancati Lead- of the Department of Medicine’s faculty since disposition Variants, as well as the Friday Scientific Dr. Godley is committed to service within the Bio- Much of her work is cited in the 2009 Institute entitled IGNITE (Improving GME Nursing Interprofes- ership and Mentorship Award, and Mid-Career 2003, Dr. Godley’s laboratory concentrates on Workshop on Inherited Hematopoietic Malignancies, logical Sciences Division. She served as the Associ- of Medicine Report on Resident Duty Hours. sional Team Experiences). Specifically, she will focus Mentorship Award, the John D. Arnold Mentoring understanding the molecular drivers of tumori- both sponsored by the American Society of Hematol- ate Director for Admissions for the Medical Science Award from Pritzker School of Medicine, most genesis, focusing on germline predisposition to ogy. Dr. Godley’s work in inherited leukemias has re- Training Program from 2011 until this year. Within recently, the Department of Medicine’s Arthur H. hematopoietic malignancies as well as the role sulted in a new provisional diagnostic category being the University of Chicago Comprehensive Cancer Rubenstein Mentoring Award. Dr. Arora is a Master of covalent cytosine modifications in mediating added to the latest leukemia classification scheme Center, Dr. Godley serves as the Chair of the Scien- of the Pritzker School of Medicine’s Academy of the transcriptional potential of chromatin. by the World Health Organization and the inclusion tific and Accrual Monitoring Committee. She also Distinguished Medical Educators and is a past of testing for germline predisposition within the serves as the University’s director for the Chicago recipient of the AOA Distinguished Faculty Award. With the Genetic Services Laboratory, Dr. Godley clinical guidelines for diagnosis and management of Biomedical Consortium, which links The University established one of the only clinical pipelines in myeloid malignancies from the National Comprehen- of Chicago, Northwestern University, and the Uni- Dr. Arora’s academic contributions have been rec- the world for testing of germline mutations that sive Cancer Network and European LeukemiaNet. versity of Illinois at Chicago in advancing biomed- Vineet Arora, MD ognized through elected membership to American increase risk for hematopoietic cancers. Along with ical science for the benefit of Chicago citizens. Professor of Medicine, Society of Clinical Investigation, and as Master by Dr. Jane Churpek, Dr. Godley provides genetic coun- In her epigenetics work, Dr. Godley studies the (General Internal Medicine), Assistant Dean for the Society of Hospital Medicine. She currently seling for patients and families suspected of having acquired mutations that occur as people age and As a mentor, Dr. Godley has an outstanding record Scholarship & Discovery at the Pritzker School of serves as Deputy Social Media Editor for the Journal a predisposition syndrome, a unique clinical ap- as leukemias develop. Dr. Godley uses chemically of guiding young investigators to successful careers Medicine and Director of GME Clinical Learning of Hospital Medicine and on the Board of Directors proach that serves as a template for other centers specific techniques to show that deposition of 5-hy- in oncology. One of her greatest strengths is her Environment Innovation at The University of Chicago for the American Board of Internal Medicine. throughout the country. Dr. Godley also receives droxymethylcytosine occurs at sites of transcription ability to mentor young female physician scien- consultations from doctors and patients through- factor binding to facilitate the expression of new tists, where she is an outstanding role-model as Dr. Arora received her MD from Washington out the country, and occasionally internationally, to transcriptional programs in response to various a successful woman who is able to effectively University, and is an alumnus of the Department’s provide genetic counseling and testing. Individuals stimuli, allowing opening of the chromatin at these balance her career and family. She has an amazing internal medicine residency program, having who test negative for known risk alleles populate sites to facilitate transcription factor binding. In col- ability to recognize the individual strengths of served as Chief Resident, and also is a graduate Dr. Godley’s cohort of families with multiple cases laboration with Dr. Bana Jabri, Dr. Godley is studying each of her mentees and then helps guide and of the University’s Harris School of Public Policy. of hematopoietic malignancies, now numbering how the microbiota contribute to the expansion of push them to achieve their true potential.

2018 Annual Report 7 Department of Medicine Programmatic Awards: of leukemogenesis and cardiovascular diseases with this age-related phenomenon (Meisel, Jabri, • Infections and the Stability of Transplantation • University of Chicago Comprehensive Cancer Godley, Barreiro, et al., Nature, 2018) and discov- Tolerance (P01) – Marisa Alegre, MD, PhD+ Center (P30) – Michelle Le Beau, PhD+ ered the role of PHGDH in pulmonary fibrosis (Hamanaka, Guzy, Wu, Dulin, Mutlu, American • Diabetes Research Training Center (P60) – • Integrative Consequences of Hypoxia (P01) – Journal of Respiratory Cell and Molecular Biology, Graeme Bell, PhD+ Nanduri Prabhakar, PhD 2018). Medicine investigators also developed PD1 pathway-directed agents for cancer immunother- • Inflammatory Bowel Disease and Mucosal Inflam- • Pathogenesis of Calcium Nephrolithiasis (P01) – apy (Matson, Gajewski, Alegre, Luke, et al., Science, mation, Immunology, and Microbiology of the G.I. Elaine Worcester, MD+ 2018) and provided new insights to further the Tract (P30) – Eugene Chang, MD understanding and therapeutic targeting of ge- nomic heterogeneity in gastro-esophageal cancer • Chicago Center for Diabetes Translation Research (Maron, Catenacci, et al., Cancer Discovery, 2018). (P30) – Marshall Chin, MD & Monica Peek, MD

The 4th annual Janet D. Rowley Research Day SELECT HIGH IMPACT AWARDS * : was held on March 6, 2018. The day commenced with an outstanding talk by Mary Armanios, MD, • Medical Scientist Training Program – • Therapeutic Targeting of Carotid Body Che- Professor of Oncology at Johns Hopkins Univer- Marcus Clark, MD moreflex for Sleep Disordered Breath- sity. Following that, 140 junior faculty and fellows ing (UH2) – Nanduri Prabhakar, PhD RESEARCH PROGRAMS participated in a poster event with all subspe- • Developing and Operating a Data Commons cialties represented. Best abstract winners in the Framework Services – Robert Grossman, PhD+ • Next–Generation Phylodynamics-target- faculty category include Hatim Hassan, MD, PhD, ed Partner Service Models for Combined Overview Megan Huisingh-Scheetz, MD, Milda Saunders, • NIAID Data Hub Pilot – Robert Grossman, PhD+ HIV Prevention – John Schneider, MD+ MD and Alexandra Dumitrescu, MD, PhD and Bow Chung, MD, Matthew Krause, PhD, Juan Rojas, MD • NHLBI Commons Pilot – Robert Grossman, PhD+ • WUMER Project – Renslow Scherer, MD The Department of Medicine has a long tradition of conducting original R series and 24 K (career development) grants. Rec- and James Godfrey, MD in the trainee category. ognition of the Department’s research programs • Innovation through collaboration at the inter- • ITM 2.0 Advancing Translational Science in and rigorous biomedical and clinical research of fundamental significance. was indicated by the consistent ranking among the Recognizing the research success of an outstand- section of childhood – Robert Grossman, PhD Metropolitan Chicago (UL1) – Julian Solway, MD+ In FY18 Medicine investigators continued to push the boundaries of top 30 NIH-funded departments of medicine in 2017. ing mid-level scientist the Department selected Yun Fang, PhD, assistant professor of medicine, • Cohen Veterans Bioscience Data Commons discovery by conducting highly collaborative, cutting edge research that In FY18, the Department conducted more than as the recipient of the 2018 Leif B. Sorensen, MD, Grant Agreement – Robert Grossman, PhD * Represents $800K+ in annual total cost funding resulted in multiple new grants and dozens of high impact publications. 1,400 clinical research studies resulting in a record PhD Faculty Research Award. Dr. Fang’s research high of $27.5M in clinical trial earnings. Important is focused on pathophysiological mechanisms • Cook County Colon Cancer Alliance to Reignite + New/competitively renewed in FY18 Furthermore, the Department’s history of excellence in training, clinical research successes include the approval of vascular diseases, particularly the modula- and Enhance Screening (CDC) – Karen Kim, MD of CAR-T cell therapy for use at the University of tion of vascular health by non-coding genome A list of the DOM’s FY18 Total Sponsored development and mentorship of bright young scientists resulted in 6 junior Chicago Medicine, and as the first center in the in the context of cardiovascular complication • University of Chicago Program for Expanded Research Awards can be found at: faculty investigators earning their first independent NIH research funding, Chicago metropolitan area to have this therapy (atherosclerosis) and pulmonary disease (acute Human Immunodeficiency Testing for Dispro- medicine.uchicago.edu available as a standard of care. Another signifi- lung injury). In FY18, Dr. Fang was awarded two portionately Affected Populations in Healthcare and 5 receiving new individual NIH K awards. cant national clinical trial, known as MOMENTUM 3 NIH R01s in support of his innovative work. Settings in Chicago (CDPH) – David Pitrak, MD and conducted by the Department’s heart failure In FY18 faculty in the Department of Medicine Founding Director) was also awarded five years of investigators (Nir Uriel, MD - Director), determined 2018 Janet D. Rowley acquired 75 new or competitively renewed federal funding totaling $35M. The ITM is a health research that a fully magnetically levitated centrifugal-flow Research Day awards resulting in a 30% increase in federal grant accelerator that develops innovative approaches to pump was superior to a mechanical-bearing Abstract Winners funding as compared to the previous year. Among advance the science and the practice of clinical and axial-flow pump in patients with advanced heart these awards are 2 competitively renewed P30’s: translational research by working hand-in-hand failure. Results from this work were published in The University of Chicago Comprehensive Cancer with health stakeholders throughout Chicagoland. the New England Journal of Medicine in 2018. Center (Michelle Le Beau, PhD - PI) and the Diabetes Research and Training Center (Graeme Bell, PhD - During the past academic year, the Department of Over the past year, Medicine investigators led or PI), and two competitively renewed P01’s focused Medicine’s research portfolio totaled nearly $84M participated in many collaborative studies and on infections and the stability of transplantation in federal awards, $32M in industry funded grants/ continued to translate basic research to clinical tolerance (Marisa Alegre, MD, PhD - PI) and the clinical trial earnings and almost $12M in non-fed- practice with multiple seminal discoveries, publish- pathogenesis of calcium nephrolithiasis (Elaine eral awards. The Department is home to seven ing over 1600 impactful papers with dozens in high Worcester, MD - PI), respectively. Also notewor- NIH funded program or center grants, 12 U-series profile journals. For example, scientists elucidated thy, The University of Chicago-Rush Institute for (cooperative agreements), 11 T series and three K12 the interaction between clonal hematopoiesis Translational Medicine (ITM) (Julian Solway, MD - training programs. Other federal awards include 51 and the microbiome to explain the association

2018 Annual Report 9 Gastroenterology procedure volumes totaled With leadership from Linda Druelinger, MD and of a 5th outpatient dialysis unit, Park Manor, under nearly 19,000 with the largest increase in inter- Thomas Spiegel, MD, the Department celebrated the direction of Rita McGill, MD. A 6th outpatient ventional procedures, the majority from endo- the opening of the new Emergency Department (ED) dialysis unit, Brighton Park, opened July 2018. scopic bariatric procedures including endoscopic in December, 2017. Since that time, ED visits grew sleeve gastroplasty. The Department’s cardiac by 6.8% and totaled 70,000. Despite the increase in Within the area of clinical research, many of the programs had a highly successful year with the volume the ED has seen a 20% decrease in diversion Department’s dedicated clinicians produce practice electrophysiology program showing continued hours and a significant decrease in patients left changing clinical research. The Department has a ro- growth of complex ablations for atrial fibrillation without being seen over the past year allowing phy- bust and highly productive therapeutic clinical trials and ventricular fibrillation (VT), becoming one of sicians to provide much needed care and emergency program and broad expertise in drug development, the largest VT ablation programs in the coun- services to the community and beyond. On May 1, especially targeted therapies. In FY18 the Department try. The Interventional Cardiology (IVC) Program 2018 UCM opened a Level 1 Adult Trauma Center conducted more than 1,400 clinical research studies, grew procedural volume by 15%, and for the first bringing highly skilled trauma care to the South Side including nearly 500 industry-funded studies. time, performed more than 550 percutaneous of Chicago. Since the opening, the Trauma Center has coronary intervention procedures in one year. become one of the busiest in the state of Illinois. In FY18 the University of Chicago Medicine contin- ued to be recognized as one of the safest hospitals In FY18, UCM performed 315 transplants with In addition to the expansion of emergency services, in the country for the 13th consecutive time by the bone marrow transplants accounting for about the Department increased its clinical footprint in the prestigious and independent Leapfrog Group. In half (141) of the volume. With the FDA’s approval of city and the region with significant presence at the Leapfrog’s semi-annual Hospital Safety Score, UCM CLINICAL PROGRAMS CAR-T cell therapy for adult patients with cer- UCM new offsite practices in Orland Park and in Chi- garnered “Straight A’s” designation for its consis- tain blood cancers, UCM is the first center in the cago’s South Loop that includes clinical programs in tency in delivering the highest level of quality and Chicago metropolitan area to have this therapy cardiology, primary care, oncology, gastroenterology, protecting its patients from preventable medical Overview available as a standard of care. In FY18 a total of diabetes and pulmonology, and complement the five errors, injuries and infections while in the hospital. 28 CAR T-cell procedures were performed. The ambulatory care centers run by Ingalls throughout Advanced Heart Failure Program performed a the South and Southwest suburbs. In addition, In FY19 the Department looks forward to the total of 31 heart transplants including 2 heart-kid- cardiology, GI and liver physicians have increased opening of the UCM’s new ambulatory site at The Department of Medicine is an institutional lead- ney transplants with a remarkable 100% 1-year their clinical services at several satellite clinics in the River East Center that will consolidate the er as measured by faculty count and physician work survival rate, earning the program the high- northwest Indiana. The Section of Nephrology’s practices at 150 E. Huron and the Obstetrics/ RVUs generation, and a major contributor to the est transplant score in the state of Illinois. joint venture with DaVita resulted in the opening Gynecology Streeterville into one location. overall success of the University of Chicago Medicine (UCM). In FY18, DOM clinical faculty continued to per- Department of form at a strong level by generating nearly 1.17 mil- Medicine’s Advanced lion physician work RVUs (wRVUs), representing a 5% Heart Failure Team increase over last fiscal year. On the inpatient side, admissions increased 7.2 % to approximately 14,300. Supporting the inpatient operations are 40 hospital- ists and a team of 6 advanced practice nurses and physician assistants who provide care to a growing volume of patients (110+ per day) at UCM. The De- partment‘s on-site outpatient subspecialty practices and primary care visits totaled 199,000 (up 2.6% over The Department of Medicine’s clinical programs demonstrate excellence last year) while the offsite subspecialty practices at 150 E. Huron and at South Shore Senior Health across a broad spectrum of subspecialty patient care services for the treatment Center recorded 14,226 and 7,616 visits, respectively. Ambulatory initiatives such as open access clinic of highly complex diseases and are comprised of clinical innovators who spots and strategic use of overbooking rules for clinician templates have increased patient access continue to impact patient care with a multitude of groundbreaking therapies and contributed to patient numbers and improved patient satisfaction. In addition, the Department’s and technologies. The most significant highlights from the past academic Clinical Operations Committee (Matthew Sorrentino, MD - Director) launched a new monthly provider year include growth in inpatient and outpatient activity, the opening of a new dashboard, that also resulted in improved patient access. Under Dr. Sorrentino’s guidance, a new Emergency Department, and expanded presence of Medicine clinicians at formal educational curriculum for the cardiac and hematology/oncology services was developed that offsite ambulatory locations. has resulted in improved housestaff satisfaction .

2018 Annual Report 11 tional opportunity for all trainees at the institu- med-peds faculty along with rigorous training in tion and a needed resource for the community. both disciplines and the diverse patient popula- tion attract top applicants. Candidates are also The Section of Dermatology endeavors to provide attracted to the LUCENT primary care track and excellent resident and fellowship education and the MedPeds PATHways (Program for Adoles- training while furthering the field of academic cent and Adult Transition to Health) program to dermatology and delivering comprehensive skin improve care of adolescents and young adults Division of Biological care to a diverse patient population. The Section with chronic childhood conditions. In FY18, two Sciences Awards: hosted the annual Chicago Dermatological Society graduating medicine-pediatric residents com- • Distinguished Educator (Junior) Award – Wei Wei Lee, MD Educational Conference in December, 2017. This pleted the MERITS medical education fellowship event included the Allen Lorincz Memorial Lecture and one completed the LUCENT track. All four Department of Medicine Awards: presented by Tammie Ferringer, MD, Section matched at competitive fellowships in palliative • Preclinical Teacher of the Year – Jeanne Farnan, MD Head, Dermatopathology and Dermatopathology care, hematology-oncology, medical genetics • Clinical Teacher of the Year – Patricia Kurtz, MD Fellowship Program Director at Geisinger Medical and the Epidemiology Intelligence Service, two • Postgraduate Teaching – Monica Malec, MD EDUCATIONAL PROGRAMS Center in Danville, PA. Dr. Ferringer spoke on at the University of Chicago, one at Children’s • Arthur Rubenstein, MD Mentorship Award – Vineet Arora, MD clinicopathologic correlations and dermatopa- Hospital of Philadelphia-University of Pennsylva- • Medicine Resident Teaching Awards: thology clues to tissue infections. Dermatology nia, and one at the Centers for Disease Control. ° Andrew Aronsohn, MD Overview continues to be a highly sought after specialty ° Michael Broman, MD, PhD for trainees. The Dermatology Residency Pro- Honors: The Department of Medicine’s extraordi- ° Kamala Cotts, MD gram, led by Sarah Stein, MD received over 525 nary pool of talented educators continues to be ° Patricia Kurtz, MD applications in 2017, and successfully matched recognized for their excellence in undergraduate • Emergency Medicine Resident Awards: In an environment supporting cultural diversity and patient safety the ing MD/PhDs to continue their residency and outstanding candidates to each of the three avail- and graduate medical education both institution- ° Outstanding Emergency Medicine Faculty Member Clinical fellowship training in cardiology and pulmonary/ able positions. The Program joined with the IMR ally and nationally. In FY18, 8 faculty were recog- Teaching – Michael Hafez, MD Department of Medicine is deeply committed to the education and training critical care at the University of Chicago. Program to offer for the first time a joint prelim- nized as “Favorite Faculty” by the Pritzker gradu- ° Outstanding Emergency Medicine Faculty Member of skilled physician scientists and leaders bound for careers in academic inary internal medicine/advanced dermatology ating class, and Scott Stern, MD was honored with Mentorship – James Ahn, MD Under the leadership of Christine Babcock, MD, track to enable candidates to complete internship the Pritzker Doroghazi Clinical Teaching Award. • Resident Research Day 2018 medicine. Under the leadership of John McConville, MD, the Department’s MSc, the Emergency Medicine Residency Pro- and specialty training within the institution. The Vineet Arora, MD was awarded the Department’s ° Most Outstanding Research Poster – Brian Labadie, MD Housestaff Choice Award – Parita Patel, MD educational programs continue to successfully prepare trainees for careers gram continues to provide outstanding clinical Section hosted a busy elective and observership Arthur Rubenstein Mentorship Award and Wei Wei ° training, scholarship opportunities and leadership program reaching 21 Pritzker and visiting medical Lee, MD was the recipient of the Biological Sciences ° Most Outstanding Clinical Vignette – Anthony Kanelidis, MD in clinical medicine, teaching, and biomedical research. Within the Internal development for 16 talented Emergency Med- students on the clinical dermatology elective Division’s Distinguished Educator (Junior) Award . icine residents each year. In FY18, an excellent rotation, 28 Pediatrics, Pathology, and Geriatric Pritzker School of Medicine Medicine Residency (IMR) program, 85% of the graduates pursue sub-specialty class of 16 PGY 1 interns was recruited from 1,400 residents/fellows on dermatology electives and The Department of Medicine has a well-estab- Education and Mentorship Awards: training. The 2017 fellowship match successfully matched 27 residents into applicants representing many of the top medical one visiting resident observer through the Center lished track record of excellence in training, • Doroghazi Clinical Teaching Award – Scott Stern, MD schools in the country. In addition, 50% of the new for Global Health. The Dermatopathology Fellow- development and mentorship of bright young • LDH Wood Preclerkship Teaching Award – Benjamin Ko, MD many of the most competitive and premier fellowship programs in the intern class are underrepresented minorities. The ship (Christopher Shea, MD - Director) attracted trainees poised for future leadership in biomedi- & Peter O’Donnell, MD country, including 16 who continued their training at the University of Chicago. quality and achievements of the new intern class dermatology and pathology trained graduates cal sciences. In this respect, senior investigators • Resident Humanism and Excellence in are remarkable. In addition, 50% of the graduating seeking specialty training in dermatopathology, continue to provide a nurturing environment that Teaching Award – Natalie Tapaskar, MD Cardiology was the most popular fellowship choice with 7 housestaff matching PGY 3 residents matched in competitive fellow- with over 40 applicants for one training position. fosters critical thinking, challenging paradigms, • AOA Award Banquet: ships across the country. The Section of Emergency and a collaborative spirit geared toward maximiz- Alumni Honoree – Gaurav Upadhyay, MD to outstanding programs across the country. Other frequent fellowship choices ° Medicine continues to expand its own fellowship In FY18, the Medicine/Pediatrics Residency ing the future research potential of each trainee. ° Faculty Honoree – Audrey Tanksley, MD included gastroenterology, pulmonary/critical care, hematology/oncology and programs. Top candidates were successfully Program, led by Rita Rossi-Foulkes, MD had The Department is the home to several nationally recruited for the medical education, administra- another successful match, recruiting 4 top ranked recognized medical research training programs, • Favorite Faculty Award Winners: palliative care. tion, and global education emergency medicine candidates into their 4 open slots. Incoming resi- including 10 NIH-funded training (T32s ) grants ° Keme Carter, MD fellowships. The Section was also approved by the dents consisted of graduates from the University in cardiology, adult and pediatric endocrinology, ° Adam Cifu, MD ACGME for the first and only Emergency Medicine of Washington, University of Illinois at Chicago oncology, respiratory biology, digestive diseases, ° Wei Wei Lee, MD In FY18, Amber Pincavage, MD and Jason Alexan- to be attracted to the rigorous clinical training, Services Fellowship in Chicago. A brand new, state College of Medicine, and University of Utah. All are mental health and disease, clinical therapeutics, ° Jason Poston, MD der, MD led the Internal Medicine Intern Selec- diverse patient population and outstanding of the art Adult Emergency Department opened members of the Gold Humanism Honor Society social science and aging, as well as the medical ° Mindy Schwartz, MD tion Committee. An exceptional PGY 1 class of 41 faculty mentorship. 20% of the new intern class in December 2017 and a Level 1 Trauma Center and have been leaders at their respective medical scientist training program. The Department also ° Scott Stern, MD interns was successfully recruited from almost is underrepresented minorities. The Physician opened on May 1, 2018. Trainees are now provided schools and have dedicated themselves to serving holds three NIH K12 grants in oncology, HIV-related ° Monica Vela, MD 1,900 applicants. IMR applicants from some of Scientist Development Program (PSDP), which is the opportunity to care for patients afflicted with vulnerable populations. Strong faculty men- – cardiovascular disease and sleep disorders and ° James Woodruff, MD the most prestigious medical schools continue led by James Liao, MD, recruited three outstand- traumatic injuries. This is an outstanding educa- torship by our internal medicine, pediatric and outcomes research and three F series NIH awards.

2018 Annual Report 13 SECTION OF The Interventional Cardiology (IVC) Program (Sandeep Nathan, MD and Atman Shah, MD- Impactful Co-Directors) grew procedural volume by 15%, Cardiology and for the first time, performed more than 550 Accomplishments Professors: percutaneous coronary intervention procedures James Liao, MD (Chief) Cevher Ozcan, MD in one year. New initiatives include a Pulmonary and Discoveries: Jeanne DeCara, MD Jonathan Paul, MD Embolism Program with IVC filter placement Dorothy Hanck, PhD (Emeritus) Tamar Polonsky, MD, MSCI and the expansion of Pulmonary Embolism • Francis Alenghat, MD, PhD and Cevher Ozcan, MD Roberto Lang, MD Jayant Raikhelkar, MD Response Team as well as the development of – Recipients of the American Society of Clinical Victor Mor-Avi, PhD* Nitasha Sarswat, MD the Chronic Thromboembolic Disease Clinic. Investigators Young Physician Scientist Award Matthew Sorrentino, MD Gabriel Sayer, MD Nir Uriel, MD Bryan Smith, MD In FY18, the Cardiac Imaging Center (Roberto Lang, • Roderick Tung, MD and Jonathan Paul, MD – Parker Ward, MD Corey Tabit, MD, MBA, MPH MD - Director) continued to experience increased Recipients of the Biological Sciences Division Gaurav Upadhyay, MD volumes of echocardiograms, with more than Distinguished Leaders in Program Innovation Associate Professors: Rongxue Wu, PhD* 20,000 performed, and cardiac MRIs. The Cardiac Awards (Senior and Junior category, respectively) Sandeep Nathan, MD, MSc Imaging Center continues to develop state of the Hemal Nayak, MD Instructor: Dr. James K. Liao art imaging technologies such as 4D-MRI flow, • Drs. Michael Davidson, Jeanne DeCara, Amit Patel, MD Wenndy Hernandez, PhD novel strain imaging, virtual and augmented reality, Roberto Lang, James Liao, Atman Shah, Atman Shah, MD live holography, transillumination, CT perfusion, Matthew Sorrentino, Roderick Tung, Roderick Tung, MD Clinical Associates: Under the leadership of James K. Liao, MD, the Section of Cardiology continued of Mary, the South Loop and at 150 E. Huron. In CT-FFR, and fusion imaging. In FY18, the imaging Nir Uriel, and Parker Ward – Named as Top Marlon Everett, MD its strategic growth and development across all missions. In FY18 major sec- FY18, Tamar Polonsky, MD was named as Director faculty published over 30 peer reviewed journal Cardiologists by Chicago magazine (May 2018) Assistant Professors: Ankur Shah, MD of the General/Preventive Cardiology Program articles and remained as active participants in Karima Addetia, MD Evan Stein, MD tional accomplishments include the addition of 4 new faculty, expansion of the where she developed new collaborations with the major scientific societies and at national meetings. • Ilya Karagodin, MD – Recipient of the 2018 Francis Alenghat, MD, PhD clinical footprint, and several high impact discoveries. Department of Obstetrics & Gynecology (pre-ec- American Society of Echocardiography Coun- Zaid Aziz, MD Part Time: lampsia/HTN clinic), Women’s Health, Vascular The Section of Cardiology’s translational and clinical cil on Vascular Ultrasound Abstract Award Andrew Beaser, MD Michael Davidson, MD In FY18 the Section welcomed five junior faculty expert in the management of patients with heart Medicine, the Hypertension Clinic and the Lipid research programs are robust and resulted in many John Blair, MD to enhance its heart failure, electrophysiology failure, heart transplantation and clinical manage- Clinic as well as expanding the Cardio-oncolo- high impact publications in FY18. The Advanced HF • Sandeep Nathan, MD – Appointed as Course Michael Broman, MD, PhD Section Administrator: and general cardiology programs. Joining the ment of circulatory assist devices. He is a leader gy Program (Jeanne DeCara, MD - Director). team produced more than 41 peer-reviewed and Co-Director, C3 (Complex Cardiovascular Sara Kalantari, MD Noel Frierson-Lyttle heart failure program were Sarah Kalantari, MD in the field of mechanical circulatory support, review papers over the past year in journals such as Catheter Therapeutics) Advanced Endovascular Gene Kim, MD who focuses her work on the management of including the use of left ventricular assist devices The EP Program (Roderick Tung, MD - Director) also New England Journal of Medicine, Journal of Heart and Coronary Intervention Global Summit *Research track faculty advanced heart failure patients and invasive (LVADs), and in the medical management of patients had a successful year with continued growth of and Lung Transplantation Nature Review - Cardio- hemodynamics, and Bryan Smith, MD, who is who need a heart transplant. Dr. Uriel’s innova- complex ablations for atrial fibrillation (AF) and vascular Medicine, Journal of the American College of interested in heart failure outcomes disparities. tive work has helped redefine current eligibility ventricular fibrillation (VT), becoming one of the Cardiology and Circulation. Clinical research by EP in- Within the electrophysiology (EP) group, An- criteria for advanced heart failure therapy in these largest VT ablation programs in the country with vestigators resulted in 2 papers that were among the DURING THE PAST YEAR, drew Beaser, MD is interested in risk factors for high-risk patients. Dr. Uriel’s research focuses earned recognition as an epicardial magnet center top 4 notable clinical papers of the year chosen by SECTION OF CARDIOLOGY INVESTIGATORS: sudden cardiac death through understanding the on the prevention and treatment of advanced and designation as the main site for magnetic the Heart Rhythm Society. In new grants, Dr. Liao was mechanisms underlying arrhythmia. In general heart failure and the care of high-risk transplant navigation for VT ablation in the United States. the recipient of a NIH R01 investigating mechanisms • Redefined hypertension and assessed • Found that mechanical chest compressions cardiology, Corey Tabit, MD is a translational patients, such as those who are HIV-positive or underlying vascular aging and Dr. Tung received new guidelines for the treatment of high improve rate of return of spontaneous circulation physician-scientist with an interest in vascu- who have received significant radiation ther- The Advanced Heart Failure (HF) Program (Dr. funding to conduct first randomized prospective blood pressure (Bakris, Sorrentino, et al., and allow for initiation of percutaneous circula- lar development, homeostasis, and situational apy to the chest during cancer treatment. Uriel - Director) performed a total of 31 heart multi-center VT ablation trial (FACILE VT) and addi- New England Journal of Medicine, 2018) tory support during cardiac arrest in the cardiac response. Wendy Hernandez, PhD, instructor, transplants including 2 heart-kidney transplants tional funding to conduct first randomized investi- catheterization laboratory (Venturini, Shah, focuses her work on the genetics of cardiovascu- Within the clinical programs, the Section continues with a remarkable 100% 1-year survival rate, gational device exemption trial to assess efficacy of • Found that people living in areas that restrict trans Nathan, Paul, Blair, et al., Resuscitation, 2017) lar disease in under represented populations. to push the boundaries of clinical practice with receiving the highest transplant score in the state septal ablation for hypertrophic cardiomyopathy. fats in foods had fewer hospitalizations for heart several new initiatives and innovative patient care of Illinois. During the past year, the HF group attack and stroke compared to residents in areas • Determined that platelet ROCK2 plays important On July 1, 2017 Nir Uriel, MD was named as the Louis including the expansion of clinical operations to performed 49 LVADs with a current 1-year survival In the educational realm, the Section is home to one without restrictions (Brandt, Polonsky, et al., JAMA role in platelet function and thrombosis, but does Block Professor. Dr. Uriel is a nationally recognized offsite practice in Orland Park, Little Company rate (compiled over the past 4 years) of 84%. of the oldest National Institutes of Health-funded Cardiology, 2017). This paper received widespread not contribute to the pathogenesis of athero- cardiovascular research programs in the nation as media attention and earned The International sclerosis and vascular remodeling (Sladojevic, well as four ACGME accredited fellowship training Society of Pharmacoeconomics and Outcomes Re- Liao, et al., Cardiovascular Research, 2017) programs. The 9th annual Morton F. Arnsdorf Car- search Award for Excellence in Application in Phar- diovascular Sciences Research Day featured nearly macoeconomics and Health Outcomes Research. • Used high-resolution multielectrode mapping Dr. Andrew Beaser 106 presentations by faculty and trainees in Cardi- to gain new insights into atrial activation during Dr. Sarah Kalantari ology as well as other sections and departments. • Determined that a fully magnetically levi- typical atrioventricular nodal reentrant tachy- Dr. Bryan Smith In FY18, Michael Broman, MD, PhD was recognized tated centrifugal-flow pump was superior cardia (Chua, Tung, et al., Heart Rhythm, 2018) Dr. Corey Tabit for excellence in teaching by the Department of to a mechanical-bearing axial-flow pump in and developed criteria for His- bundle pacing Medicine Residency Program and Gaurav Upadhyay, patients with advanced heart failure (Meh- (Pugazhendhi, Lustgarten, Tung, et al., Heart MD was the recipient of the AOA Alumni Honoree ra, Uriel, MOMENTUM 3 Investigators, et al., Rhythm, 2018). This paper earned notable paper Award from the Pritzker School of Medicine. New England Journal of Medicine, 2018) recognition from the Heart Rhythm Society.

2018 Annual Report 15 SECTION OF

Computational Dr. Polonsky honors Dr. Grossman as the Biomedicine Frederick Rawson Professor and Biomedical Data Science

Dr. Robert L. Grossman Dr. Andrey Rzhetsky

The Section of Computational Biomedicine and Biomedical Data Science was established In October 2016 under the leadership of Robert Grossman, PhD and Andrey Rzhetsky, PhD. Dr. Grossman, the Frederick H. Rawson Professor, Professor of Computer Science and Chief Research Informatics Officer of the Biological Sciences Division, is an expert in translational data science and its applications to biology, medicine and healthcare. Dr. Rzhetsky, the Edna K. Papazian Professor, is an expert in computational analysis of complex human phenotypes.

In FY18, Dr. Grossman established an archi- Oncology, May/June 2018. Here he also discussed Protection Agency personnel to examine associ- tectural framework called the Data Commons data commons and their potential role in cancer ations between environmental quality and adult Framework (DCF) for the National Cancer Insti- data ecosystems and, in particular, how multiple asthma prevalence in the USA. This study found tute’s Cancer Research Data Commons (CRDC), a data commons can interoperate to form part of that asthma may be driven by multiple expo- collection of data commons spanning not only the foundation for a cancer data ecosystem. sures operating in tandem and that worsening cancer genomics, but the broad types of data overall environmental quality is associated with relevant to cancer research, including proteom- Dr. Grossman continued to lead the development increasing asthma. Results from this study were ics, immune-oncology, cell atlases and imaging. and operations of the NCI Genomic Data Com- reported in Environmental Research 166, 2018. The DCF is a set of software services to aid in the mons, which is a platform for sharing large cancer development, operation, and interoperation of genomic datasets. During the past year, the GDC In other collaborative studies, Dr. Rzhetsky data commons, data clouds, knowledge bases, was used by over 100,000 researchers. The GDC is worked with Ishanu Chattopadhyay, PhD (Hospital and other resources for managing, analyzing, and also the basis for an ecosystem of bioinformatics Medicine) and Joshua Elliott, PhD (Computation sharing cancer research data that are part of the applications for analyzing the data it contains. Institute), and researchers from Microsoft and CRDC. The CRDC is an example of a data eco- The approach taken by the GDC to support this Columbia University, investigating the source system recommended by the Cancer Moonshot ecosystem of cancer genomics applications and the mechanistic triggers of the seasonal Blue Ribbon Panel report from 2016 to enable all was described in Cancer Research, 77(21), 2017. influenza epidemic in the USA Elife( , 2018), and he participants “across the cancer research and care produced a series of studies regarding modes of continuum” to “contribute, access, combine and In FY18, Dr. Rzhetsky, in close collaboration with inheritance and transmission of Staphylococcus analyze diverse data.” The CRDC is an important Ji-Sung Kim from Princeton University, developed aureus skin colonization in human populations in first step towards a cancer data ecosystem. To a deep learning system for imputing patient’s collaboration with pediatricians from Washing- that end, Dr. Grossman reviewed approaches race and ethnicity from their partial medical ton University. Data from this study revealed for building cancer data ecosystems and recent history. Highlights from this work were reported proximity, seasonality, and hygiene practices progress in an article published in the Cancer in PLoS Computational Biology, 26(14), 2017. Dr. as key determinants of MRSA colonization in Journal: The Journal of Principles and Practice of Rzhetsky also worked closely with Environmental exposed households (Pediatric Research, 2018). Dr. Andrey Rzhetsky

2018 Annual Report 17 SECTION OF Dermatology

Dr. Diana Bolotin

FY19 Dermatology Chief Residents Professors: Clinical Associates: In March 2018, Diana Bolotin, MD, PhD, Associate Professor of more than 145 scientific papers, 113 abstracts and Christopher R. Shea, MD Juliana Basko-Plluska, MD 7 book chapters. Clinically, Dr. Soltani provides Keyoumars Soltani, MD Ashley Feneran, DO Medicine, was appointed as interim chief of the Section of Dermatology. expertise in complex procedural services. He is John Fox, MD Dr. Bolotin currently serves as Director of Dermatologic Surgery and Medical triple board certified (dermatology, dermatopa- Associate Professors: Vivek Iyengar, MD thology, and dermatologic immunology/diagnos- Diana Bolotin, MD, PhD Eduardo Moioli, MD Director for Dermatology Ambulatory Practice. Dr. Bolotin’s clinical and tic and laboratory immunology). As an educator, (Interim Chief) Arlene Ruiz De Luzuriaga, MD, academic interests span the field of cutaneous oncology and resident education Dr. Soltani has inspired generations of aspiring Sarah L. Stein, MD MPH, MBA with particular interests in translational research of carcinogenesis, novel skin students to pursue the specialty of dermatology, Yu-Ying He, PhD in some cases guiding them as undergraduates Section Administrator: cancer therapies and advocacy. As a fellowship-trained Mohs micrographic through to advanced clinical fellowships. Assistant Professors: Kristen Meredith surgeon, Dr. Bolotin has expertise in a wide range of medical and surgical Oluwakemi Onajin, MD+ As one of the top programs in the nation focused Adena Rosenblatt, MD, PhD +New FY19 faculty treatments within cutaneous oncology, including Mohs surgery and excision on understanding, diagnosing, and treating the treatments of cutaneous neoplasms. Dr. Bolotin is a recipient of the Medical skin and its diseases, the Section demonstrated Keyoumars Soltani, MD Dermatology Society Mentorship Award, several Chicago Dermatologic Society continued growth in procedural dermatology and Accomplishments, Highlights and Discoveries: in providing the highest quality interpretation of research awards and the American Society for Dermatologic Surgery Cutting dermatopathology cases in FY18. Additionally, • Diana Bolotin, MD, PhD – Recipient of • Christopher R. Shea, MD – Recognized by Chicago Edge Research Award and has participated in numerous clinical trials within the Section expanded their adult and pediatric an American Society for Dermatologic magazine (January 2018) as a Top Doctor dermatologic services to off-site locations at 150 skin tumorigenesis and tumor progression with Surgery Cutting Edge Research Grant the field of procedural dermatology. Dr. Bolotin has authored multiple peer- E. Huron, the South Loop, Orland Park, Edwards the hope to provide new molecular insights for • Sarah Stein, MD – Named Senior Faculty Scholar in reviewed journal articles and textbook chapters within the field and serves on Hospital and Little Company of Mary Hospital. developing effective GG-NER modulators for • Yu Ying He, PhD – Elected as President of the Bucksbaum Institute for Clinical Excellence New clinical initiatives included a new collabora- cancer prevention and therapy. Dr. He’s inves- the American Society for Photobiology the editorial boards of the Journal of the American Academy of Dermatology tion with the Section of Rheumatology focused tigative efforts resulted in a Janet D. Rowley and Co-Chair of the Biennial Meeting for and Dermatologic Surgery. on treatment of dermatologic manifestation of Discovery Award to further her work in defining American Society for Photobiology rheumatologic conditions, and continued work the role of RNA methylation in melanoma. In the FY18 accomplishments for the Section of Derma- immune cells to attack the epidermis in early on the establishment of a Skin Cancer Treat- clinical research realm, Sarah Stein, MD and Adena tology include the appointment of Keyoumars lesions of psoriasis. Among other discoveries, he ment Center as multi-disciplinary center for skin Rosenblatt, MD, PhD are investigating the use of Soltani, MD as the Allan L. Lorincz Professor of developed a new immune diagnostic method for cancer prevention, detection and treatment. ixekizumab for treatment of pediatric psoriasis. The Section of Dermatology’s investigative • Identified a new role of autophagy path- Dermatology. Dr. Soltani is an authority on the cutaneous lesions of syphilis, introduced the term programs have continued to make key con- ways in inflammation and tumorigen- treatment of skin cancers, cutaneous surgical pro- pemphigoid nodularis, showed that Herxheimer The Section’s investigative programs are The Dermatology Residency Program, un- tributions to research in skin conditions, esis (He, et al., Autophagy, 2017) cedures, graft-versus-host disease and blistering reaction was not complement dependent, and focused on the fundamental question of how der the direction of Dr. Stein and associate carcinogenesis, and melanocyte differen- conditions who has served the Department of demonstrated that cutaneous lesions in congen- cells respond to radiation and chemicals from program director, Dr. Rosenblatt, continues tiation. Significant highlights include: • Conducted a retrospective analysis of 129 Medicine, Biological Sciences Division and the Uni- ital lupus may develop without sun-exposure. internal or external sources to cause cancer. In to recruit and train outstanding young der- patients with squamous cell carcinoma In Situ versity of Chicago with distinction and dedication His recent work includes a collaborative effort FY18, Dr. Yu-Ying He’s laboratory continued to matologists. The Dermatopathology Fellow- after diagnostic biopsy that demonstrated for nearly 50 years. As a scientist, Dr. Soltani was investigating autophagy regulation of inflamma- investigate the mechanism of global genome ship Program also remains strong, providing • Identified a new post-transcription- that immunosuppressed patients have per- the first to show that lymphocytes, not polymor- tion and skin tumorigenesis. Over the course of his nucleotide excision repair (GG-NER) regulation an excellent training experience to an elite al mechanism regulating DNA repair (He, sistent tumors more frequently after biopsy phonuclear leukocytes, were initial inflammatory/ career he has contributed to the literature with by autophagy, and its impact on UVB-induced group of dermatologists and pathologists. et al., Nucleic Acids Research, 2018) (Bolotin, et al., Dermatologic Surgery, 2017)

2018 Annual Report 19 SECTION OF

DURING THE PAST Emergency Medicine YEAR, SECTION OF EMERGENCY MEDICINE INVESTIGATORS:

• Provided evidence that DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity (Nanduri, Dr. Claire Abramoff Prabhakar, Peng, et al., Journal of Physiology, 2017) Dr. Krystal Baciak Dr. Nadim Hafez • Provided evidence that HIF - 1 alpha is required Dr. Alejandro Palma for disturbed flow-induced metabolic reprogram- Dr. John Purakal ming in human and porcine vascular endothe- Dr. Quincy Moore lium (Wu, Prabhakar, Mutlu, et al., Elife 2017) Dr. Kimberly Stanford Dr. Linda Druelinger • Found that Pyruvate dehydrogenase activity im- proves cardiac outcomes and is a promising ther- apeutic target for improving post-cardiac arrest Professors: Assistant Professors: Part time Faculty: resuscitation (Piao, Sharp, et al., PLoS One, 2017) Linda Druelinger, MD (Chief) James Ahn, MD Katie Tataris, MD, MPH Eric Beck, DO Ira Blumen, MD Krystal Baciak, MD Andrew Bokarius, MD Under the leadership of Linda Druelinger, MD, the Section of Emergency Medicine was responsible for two major insti- • Investigated the different roles of local and David Howes, MD Daniel Bickley, MD+ Clinical Associates: Cai Glushak, MD tutional accomplishments in FY18. After years of planning, the new Adult Emergency Department (ED), (Thomas Spiegel, long-range inhibition in the respiratory net- Jayasri Nanduri, PhD* Keegan Checkett, MD Diane Chaney, MD Thomas Fisher, MD work and demonstrated that inhibition affects Nanduri Prabhakar, MS, PhD, MD Navneet Cheema, MD David Harter, MD Vishal Gupta, MD MD - Medical Director) successfully opened on December 29, 2017. Since that time, the Section has experienced a 6.8% synchrony, period variability, and overall James Walter, MD Alfredo Garcia, PhD Julianne Kjolhede, MD Kamaldeep Heyer, MD growth in volume with over 70,000 patients presenting to the ED over the past year. Despite the increase in volume, the frequency of the preBötC and coupled rhyth- Nadim Hafez, MD Marshall Segal, MD mogenic networks (Harris, Shea-Brown, Garcia, Associate Professors: P. Quincy Moore, MD Medical Education Fellow: Joshua Sherman, MD ED has seen a 20% decrease in our diversion hours and a significant decrease in the left without being seen patients over et al., Journal of Neurophysiology, 2017) Christine Babcock, MD Adriana Olson, MD+ Paul Kukulski, MD the past year allowing physicians to provide much needed emergency services to the community and beyond. On May David Beiser, MS, MD Nathan Olson, MD+ Section Administrator: 1, 2018 after nearly one year of planning and the combined efforts of the Section and the Section of Trauma and Acute • Developed a conceptual model (reframe, reprior- Keme Carter, MD Alejandro Palma, MD International Medical Bradford Lane itize, and reform – 3 R’s) for religiously-tailored Teresita Hogan, MD John Purakal, MD Education Fellow: Care Surgery, University of Chicago Medicine opened a Level 1 Adult Trauma Center bringing highly skilled trauma care health messages for behavioral change (Padela, Robert Mulliken, MD Daniel Robinson, MD Nicholas Ludmer, MD+ *Research track faculty to the South Side of Chicago. Since the opening of the Trauma Center, it has become one of the busiest trauma centers Peek, et al., Social Science & Medicine, 2018) Aasim Padela, MD, MSc Willard Sharp, MD, PhD +New FY19 faculty Ying-Jie Peng, MS, PhD* Thomas Spiegel, MD, MBA, MS Administrative Fellow: in the state of Illinois. To assist with the increased demand for clinical services, the Section welcomed seven new faculty • Determined that the use of mechanical chest Kimberly Stanford, MD Zachary Jarou, MD+ in FY18: Claire Abramoff, MD (Assistant Ultrasound Director); Krystal Baciak, MD (Assistant EMS Medical Director); Nadim compressions improved the rate of return of Michael Hafez, MD (Assistant Ultrasound Director); Alejandro Palma, MD; John Purakal, MD; P. Quincy Moore, MD and Kim- spontaneous circulation and allowed for initiation of percutaneous circulatory support during cardi- Accomplishments, Highlights and Discoveries: berly Stanford, MD. ac arrest in the cardiac catheterization laboratory • Linda Druelinger, MD – Recipient of the 2018 • Navneet Cheema, MD – Recipient of the (Venturini, Shah, Beiser, et al., Resuscitation, 2017) Department of Medicine Distinguished Service Award 2018 Department of Medicine Clinical Ser- vice (Evaluation and Management Award) In other new clinical initiatives, Teresita Hogan, health fairs, and classrooms over the past year in ef- Residency Program (Christine Babcock, MD - • Suggested the development of an explicit pathway • Teresita Hogan, MD – Recipient of the Academy of MD (Director, Geriatric Emergency Medicine) in forts to improve health beliefs and health behaviors. Director) continues to attract trainees from to coordinate the care of heart failure patients Geriatric Emergency Medicine Gerson-Sanders • Nanduri R. Prabhakar, PhD – Presented the collaboration with Lauren Gleason, MD (Geriatrics outstanding medical schools, many of whom in order decrease that population’s likelihood Award; Appointed to the ACEP Board of Governors plenary lecture “Gasotransmitters and and Palliative Medicine), launched a project to In the research realm, the Section was awarded are successful at securing sought after fel- of admission without increasing emergency – Geriatric Emergency Department Accreditation sleep apnea” at the 25th Anniversary of In- improve ED management and transition of care for over $5M in extramural research funding. New lowship positions after completing residency department’s disposition times (Speigel, et al., dian Sleep Society, Goa, India, 2017 older adults presenting to the ED with injuries from grants in FY18 include a HRSA funded award for training. Relating to the Section’s global health American Journal of Emergency Medicine, 2018) • Aasim Padela, MD, MSc – Appointed as Chair a fall. The “falls” project has brought together a Aasim Padela, MD, focused on informing Amer- programs, Keegan Checkett, MD in her role as of the Ethics Committee for the Society • Christine Babcock, MD – Elected to Illinois College multidisciplinary group at UCM, including emergency ican Muslims about living donation. Within the Director for the Emergency Medicine Residency • Suggested communication strategies for improv- of Academic Emergency Medicine of Emergency Medicine (ICEP) Board of Directors medicine, geriatrics, physical therapy, social work, Center for Oxygen Sensing (Nanduri Prabha- Program in Haiti, successfully graduated the ing care of older individuals in the ED (Hogan, and case managers. Additionally, Dr. Purakal, created kar, PhD - Director) Alfredo Garcia, PhD was the first class of EM trained residents in Septem- Malsch, Clinics of Geriatric Medicine, 2018) • Willard Sharp, MD, PhD – Elected to Illinois • Alfredo Garcia, PhD – Named as Council- a public health initiative called UChicago ROCK recipient of a NIH funded R01 focused on neuro- ber 2017. James Ahn, MD (Associate Residency College of Emergency Physicians (ICEP) Board or for Chicago Chapter of Neuroscience (Raising Our Community’s Knowledge) to help at- cognitive consequences of intermittent hypoxia. Director) and Michael Hafez, MD were honored • Determined the Cincinnati Prehospital Stroke risk groups bridge the gaps in their health literacy. by the Emergency Medicine residents with the Scale can identify large vessel occlusion in stroke • James Ahn, MD – Recipient of the 2017 American ROCK has brought medical students, residents and As one of the oldest emergency medicine training Outstanding Faculty Mentorship Award and Out- patients in the prehospital setting (Tataris, College of Emergency Physicians National Emer- physicians from UCM to various community centers, programs in the country, the Emergency Medicine standing Clinical Teacher Awards, respectively. Richards, et al., Prehospital Emergency Care, 2018) gency Medicine Junior Faculty Teaching Award

2018 Annual Report 21 Professors: Assistant Professors: SECTION OF George Bakris, MD Alexandra Dumitrescu, MD, PhD Graeme Bell, PhD Siri Atima Greeley, MD, PhD Antonio Bianco, MD, PhD+ Erin Hanlon, PhD* Endocrinology, Ali Cinar, PhD* Rochelle Naylor, MD David Ehrmann, MD Katie O’Sullivan, MD Diabetes Murray Favus, MD Susan Sam, MD Louis Philipson, MD, PhD Celeste Thomas, MD Kenneth Polonsky, MD Christine Yu, MD & Metabolism Samuel Refetoff, MD** Meltem Zeytinoglu, MD Christopher Rhodes, PhD** Dr. Katie O’Sullivan Eve Van Cauter, PhD** Clinical Associates: Tamara Vokes, MD David Sarne, MD

Associate Professors: Section Administrator: Ronald Cohen, MD (Chief) Ann M. Leu Matthew Brady, PhD Dr. Ronald Cohen Dianne Deplewski, MD *Research track faculty Manami Hara, PhD* **Emeritus Drs. Louis Philipson and Silvana Pannain, MD Kenneth Polonsky Ann Zmuda, DPM

Under the direction of Ronald Cohen, MD, the Section of Endocrinology, Diabetes & Metabolism (EDM) continues to Impactful Accomplishments maintain its impressive stature as one of the top adult and pediatric endocrine centers in the nation as well as enjoy and Discoveries: • Eve Van Cauter, PhD – Presented the opening great success for its leading edge research in the genetics of diabetes and thyroid disorders and innovative education- plenary lecture of the annual meeting of the The Thyroid Study Unit (Samuel Refetoff, MD - Association of Professional Sleep Societies al programs. The Section’s most notable accomplishments in FY18 include recognition of Louis Philipson, MD, PhD, the Director) continues to work on the identification • George Bakris, MD – Served as Co-Chair of recruitment of Katie O’Sullivan, MD and the renewal of the Diabetes Research & Training Center grant. and treatment of congenital thyroid diseases, in the Blood Pressure Consensus Panel for • Samuel Refetoff, MD – Elected honorary particular those that cannot be managed by simple the American Diabetes Association member of the German Endocrine Society On January 1, 2018, Dr. Philipson was named as continues to be at the forefront for innovative endeavor that is centered at the University of hormone replacement. In FY18, Dr. Alexandra the James C. Tyree Professor in Diabetes Research diabetes research and unparalleled patient care Chicago with the participation of investigators Dumitrescu’s investigative work provided new • Rochelle Naylor, MD – Recipient of the Biologi- • Siri Greeley, MD, PhD – Awarded the 3rd Gold and Care and in May 2018, the Illinois Lincoln and community-oriented diabetes programs. from local institutions with differing scientific insights into the role of SBP2 in thyroid homeo- cal Sciences Division’s Distinguished Leader in Medal Oration Award from Dr. Mohan’s Di- Academy honored him as a laureate of the Order backgrounds, yet sharing a common interest in stasis (Fu, Dumitrescu, et al., Endocrinology, 2017) Diversity and Inclusion Junior Faculty Award abetes Education Academy (DMDEA), Inter- of Lincoln, the state of Illinois’ highest award, In FY18, Katie O’Sullivan, MD joined the faculty diabetes and related research. It includes 116 while Dr. Refetoff conducted a study that led to national Diabetes Update, Chennai, India conferred by Governor Rauner. Inspired by his of the Section of EDM as assistant professor of members with the overall goal of promoting new the identification of GLIS3 as a key regulator of teachers and colleagues at the University of medicine. Dr. O’Sullivan is a combined adult and discoveries and translating research findings into TSH/TSHR-mediated thyroid hormone biosyn- DURING THE PAST YEAR, SECTION OF Chicago, Dr. Philipson is a leading authority on the pediatric endocrinologist whose clinical and re- novel strategies for the diagnosis, prevention, thesis. Results of this study were reported in the biophysics and genetics of insulin secretion. He is search interests focus on preventing and managing treatment and cure of diabetes. Other noteworthy Journal of Clinical Investigation (Kang, Refetoff, ENDOCRINOLOGY, DIABETES & METABOLISM a tireless advocate for all patients with diabetes obesity and type 2 diabetes in children as well as grants include the renewal of Dr. Samuel Refetoff’s et al., Journal of Clinical Investigation, 2017). INVESTIGATORS: especially those with type 1 and monogenic forms improving the transition of adolescents with endo- R01 (years 45-49) investigating physiology studies of diabetes. He identified potassium channels in crine conditions from pediatric to adult healthcare of inherited thyroid disorders and a new K23 One of the unique aspects of the Section is the • Provided new insights to advance the un- • Determined the impact of insulin and metformin human insulin secreting cells, elucidated their providers. Her prior research investigated the rela- award for Rochelle Naylor, MD focused on advanc- fully integrated nature of the Adult and Pediatric derstanding of the role of SBP2 in thyroid versus metformin alone on β-cell function in role through beta cell specific deletions, then tionship between sleep deprivation in adolescents ing recognition and personalized genetic medicine training programs. With two NIH T32 grants to sup- homeostasis and for investigating seleno- youth with impaired glucose tolerance or recently developed models for their role in insulin secre- and cardiovascular outcomes including abnormal- for MODY in a multi-ethnic US population. port training in pediatric endocrinology research protein biology relevant to human disease diagnosed type 2 diabetes (RISE Consortium: tion. He co-discovered the first human insulin ities of glucose and insulin homeostasis. In addi- and integrated clinical and basic endocrinology, (Fu, Dumitrescu, et al., Endocrinology, 2017 Ehrmann, Sam, Van Cauter, Diabetes Care, 2018) gene mutations that cause diabetes. With his tion, she examined the incidence of obstructive In FY18, the Section’s clinical and outreach there is no other such program in the United colleagues Siri Atma Greeley, MD, PhD, Rochelle sleep apnea in adolescents with type 2 diabetes. programs were highlighted by several new States. The Endocrinology T32 Training Program • Redefined hypertension and assessed • Provided evidence that pancreatic histopa- Naylor, MD and Graeme Bell, PhD, they have con- initiatives. Dr. O’Sullivan worked to develop a (Drs. Bell and Refetoff – PI’s) completed its 43rd new guidelines for the treatment of high thology of human monogenic diabetes is due tributed to University of Chicago Medicine’s (UCM) The Section’s internationally recognized investi- Family-Centered Obesity Clinic, where she cares year of training endocrinology researchers and blood pressure (Bakris, Sorrentino, et al., to causal genetic variants in KCNJ11, HNF1A, reputation as the leading center for monogenic gators have made important scientific contribu- for children with obesity and their parents in a Pediatric Endocrinology T32 (Dr. Philipson - PI) New England Journal of Medicine, 2018) GATA6, and LMNA (Sanyoura, Greeley, Philipson, diabetes in the United States. He worked with tions that have impacted our understanding of the same clinical encounter and also worked to continues to train pediatric endocrinologists in et al., Journal of Clinical Endocrinology, 2018) Illinois legislature to pass “Lilly’s Law” establish- diabetes, thyroid disease, sleep and polycystic improve readiness of adolescent patients with academic research. The Committee on Molecular • Evaluated the contribution of rare variants to ing the first mandated statewide diabetes registry ovary disease. In FY18, the Diabetes Research & chronic endocrine conditions to transition to Metabolism and Nutrition (Matthew Brady, PhD type 2 diabetes and related traits using pedi- • Found that treatment with recombinant hu- in the United States. Dr. Philipson is President Training Center (DRTC) (Graeme Bell, PhD - PI), a adult providers. Celeste Thomas, MD, served as - Chair) successfully graduated three doctoral grees (Jun, Blangero, Bell, et al., PNAS, 2018) man parathyroid hormone may improve Elect for Science and Medicine of the American NIH program first funded in 1977, was successfully project leader for University of Chicago Med- students. Within the Pritzker School of Medicine, health-related quality of life in adults with Diabetes Association and serves as the Direc- renewed for years 41-45. The DRTC is a broad- icine’s Hypoglycemia Oversight Committee to Tamara Vokes, MD served as course director for chronic hypoparathyroidism (Vokes, et al., tor of the UCM’s Kovler Diabetes Center, which based interdepartmental and inter- institutional reduce inpatient insulin-related hypoglycemia. the “Using Empathy as a Clinical Tool” elective. Journal of Clinical Endocrinology, 2018)

2018 Annual Report 23 Professors: SECTION OF Dr. Bana Jabri David Rubin, MD (Chief) Edwin McDonald III, MD Eugene B. Chang, MD Dejan Micic, MD Michael Charlton, MD Sonali Paul, MD Section of Russell Cohen, MD Joel Pekow, MD Ira Hanan, MD Vijaya Rao, MD Gastroenterology, Bana Jabri, MD, PhD Atsushi Sakuraba, MD Karen Kim, MD Neil Sengupta, MD Carol Semrad, MD Valerie Abadie, PhD* Hepatology and Nutrition Helen Te, MD Irving Waxman, MD Instructors: Charles Winans, MD++ Vanessa Leone, PhD

Associate Professors: Clinical Associates: Diseases has also opened a Metabolic and Fatty responses and microbial triggers that promote Andrew Aronsohn, MD Bertram Rogers, MD Liver Clinic led by Drs. Charlton and Sonali Paul to the development of ulcerative colitis pouchitis . Marc Bissonnette, MD improve the coordination of care for hepatology Yanchun Li, PhD Part Time Faculty Dr. David T. Rubin patients. The Center for Liver Diseases has also In the educational realm the Section’s training Anjana Pillai, MD (Co-appointment opened clinics in the South Loop, Orland Park, program (Gautham Reddy, MD - Director) had Kapuluru Gautham Reddy, MD with ANL): Hinsdale, and at the 150 E. Huron location. The a very successful fellowship match, recruiting Uzma Siddiqui, MD Dionysios Antonopoulos, PhD Section anticipates significant continued growth five new subspecialty advanced fellows (trans- Folker Meyer, PhD in their liver and liver transplant volumes in FY19. plant hepatology, IBD, nutrition, interventional Assistant Professors: Under the direction of David T. Rubin, MD, the Section of Gastroenterology, Hepa- the testing of novel therapies aimed at blocking endoscopy). In addition, the Section imple- Christopher Chapman, MD Section Administrator: IL-15 signaling in severe cases of celiac disease. The Center for Endoscopic Research and Ther- mented multiple changes to the curriculum and Sushila Dalal, MD Mark Mitchell tology and Nutrition continued its growth across the clinical, research and educa- apeutics (Irving Waxman, MD - Director) has rotations that will allow the Section to con- Murat Eren, PhD Also in FY18 the Section welcomed two new continued to show significant increases in tinue to be the leader in developing academic Robert Kavitt, MD *Research Track Faculty tional programs. In FY18, the major sectional accomplishments include a named faculty: Vijaya Rao, MD and Dejan Micic, MD. Dr. patient volumes. Much of this has been due gastroenterologists in the coming years. Sonia Kupfer, MD ++Emeritus Rao cares for patients with a variety of diges- to the recent growth of the Endoscopic Treat- professorship, the successful recruitment of two clinical faculty, the significant tive diseases, with a particular interest in Celiac ments for Obesity Program led by Chris Chap- disease, inflammatory bowel disease, colon cancer man, MD. In FY18, over 75 endoscopic bariatric increase in clinical presence at seven of the the University of Chicago Medicine’s screening, and women’s health issues within procedures were performed, including the first Accomplishments, Highlights and Discoveries: gastroenterology. Since her recruitment, she has endoscopic sleeve gastroplasty in Chicago. • Andrew Aronsohn, MD – Recipient of Department of • Helen Te, MD – Appointed by the Bucksbaum Institute (UCM) offsite and satellite clinic locations, and the major research contributions contributed to the Section’s growth strategy with Medicine 2018 Medical Resident Teaching Award for Clinical Excellence as a Senior Faculty Scholar the GI practices at South Loop and 150 E. Huron. With nearly $9M million in annual research funding, that resulted in numerous publications and new grants. Dr. Micic has a special interest in inflammatory investigations in IBD, immunology, celiac disease, • Karen Kim, MD – Awarded the Biological Sciences • Drs. Carol Semrad, Helen Te, Irving Waxman – bowel disease and management of gastrointestinal and GI cancer serve as the cornerstone of the Division 2018 Distinguished Leader in Diversity Award Named as Top Doctors by Chicago magazine In FY18, Bana Jabri, MD, PhD was named as the Sara discoveries have demonstrated the possibility that conditions resulting in nutritional disorders such Section’s research programs. Under the direction and Harold Lincoln Thompson Professor in recog- vaccines could one day be used to prevent the dis- as short bowel syndrome and intestinal malab- of Eugene B. Chang, MD and Dr. Jabri the basic/ • Bana Jabri, MD, PhD – Recipient of the 2017 nition of her groundbreaking work focused on the ease. Dr. Jabri’s revolutionary work includes the dis- sorption, and serves as an important contribu- translational research agenda combines assets of Lloyd Mayer Mucosal Immunology Prize study of celiac disease and mucosal immunology, covery that signals from tissue cells control effec- tor of the GI Nutrition and Small Bowel team. the Biological Sciences Division, Marine Biological and seminal discoveries relating to the mecha- tor immune responses, in particular combinations Laboratory, and Argonne National Laboratory to nisms underlying the development of complex of stress-induced ligands and IL-15 license cytotoxic The Inflammatory Bowel Disease Center (Russell investigate the role of the intestinal microbiome inflammatory disorders. Her work has led to new T cell to mediate tissue damage. She also identified Cohen, MD - Director) continues to advance IBD that impacts health and disease, gut immune insights in determining what triggers the abnormal the mechanism underlying the association between care in the region and as one of the country’s pre- regulation and oral tolerance, genetics, celiac DURING THE PAST YEAR, SECTION OF reaction to gluten in celiac disease and recent HLA-DQ8 and celiac disease. Her research group eminent programs. IBD care is now available at the disease, and pathobiology of GI cancers. In FY18, GASTROENTEROLOGY, HEPATOLOGY AND NUTRITION went on to develop the first-ever mouse model of Orland Park clinic, expanding the Section’s reach the Section was awarded multiple new federal INVESTIGATORS: celiac disease, which has allowed for the testing to patients in the southwest suburbs. In new initia- and non-federal grants studying the microbiome, of new vaccines and therapeutic strategies. Using tives, the Section is currently providing endoscopy immunology, and IBD. Marc Bissonnette, MD was • Demonstrated the importance of microbial signals • Demonstrated that IgA antibodies reactive to this model, her team demonstrated critical roles services for IBD patients at the 900 N Michigan Sur- awarded a NIH U01 to study the development in the development of pre-leukaemic myelopro- the microbiota are selected for polyreactivity for both Vitamin A and IL-15 in the pathogenesis of gery Center which allows GI physicians the ability of 5hmC and 5mC biomarkers in cell-free circu- liferation prompting new lines of investigation (Bunker, Bendelac, Jabri et al., Science, 2018) celiac disease. These findings have profound impli- to provide comprehensive care to the IBD patients lating DNA for sensitive colon cancer detection that may profoundly affect the prevention and cations not only for celiac disease but also for the who are seen at the 150 E Huron ambulatory clinic. and prognosis. Sonia Kupfer, MD received an NIH management of haematopoietic malignancies • Developed a novel salvage therapy for severe fields of both autoimmunity and mucosal immunol- R21 to investigate host-environment interac- (Meisel, Jabri, Chang, Eren, et al., Nature, 2018) ulcerative colitis (Christensen, Cohen, Rubin et al., ogy, including the engineering of oral vaccinations The Liver Transplant Program (Michael Charlton, tions in colorectal cancer disparities. Dr. Chang Clinical Gastroenterology & Hepatology, May 2018) and understanding how dysregulated immune MD- Director) continues to grow and expand. received funding from Takeda entitled “PROM- • Found that small intestine microbiota regu- responses to luminal food antigens can lead to the In FY18 the multidisciplinary Liver Tumor Clinic ise“ to establish an IBD organoid bank at UCM, late host digestive and absorptive adaptive development of food allergies and inflammatory (Anjana Pillai, MD- Director) saw significant and with Dr. Jabri, was awarded a grant from responses in dietary lipids (Martinez-Gu- Dr. Dejan Micic Dr. Vijaya Rao bowel disease (IBD). Her work has directly led to increases in patient volumes. The Center for Liver Helmsley Foundation to study aberrant tissue ryn, Chang, et al., Cell Host Microbe, 2018)

2018 Annual Report 25

SECTION OF Professors: Associate Professors: Clinical Associates: Deborah Burnet, MD, MAPP (Chief) Dionne Blackman, MD Irsk Anderson, MD Joseph Asbury, MD Diane Altkorn, MD Kamala Cotts, MD Mim Ari, MD Gomez Charleston, MD General Vineet Arora, MD, MAPP Rajlakshmi Krishnamurthy, MD Arshiya Baig, MD, MPH Marius Commodore, MD Halina Brukner, MD Wei Wei Lee, MD Neda Laiteerapong, MD, MSCP Ashley Martin, MD Internal Medicine Marshall Chin, MD, MPH David Liebovitz, MD Susan Nasr, MD+ Sandra Naaman, MD Adam Cifu, MD Doriane Miller, MD Valerie Press, MD, MPH Andrew Davis, MD, MPH Julie Oyler, MD Jennifer Rusiecki, MD, MS Section Administrator: John Flynn, MD Monica Peek, MD, MPH, MS Milda Saunders, MD, MPH Cindy Kitching Elbert Huang, MD, MPH Amber Pincavage, MD Todd Stern, MD Mindy Schwartz, MD Rita Rossi-Foulkes, MD, MS Anna Volerman Beaser, MD +New FY19 Faculty Mark Siegler, MD Sachin Shah, MD George Weyer, MD Scott Stern, MD James Woodruff, MD Assistant Professors: Instructors: Monica Vela, MD Nabil Abou Baker, MD Elizabeth Tung, MD, MS Lisa Vinci, MD, MS Jason Alexander, MD Dr. Deborah Burnet Accomplishments, Highlights and Discoveries: Under the leadership of Deborah Burnet, MD, MAPP, the Section of General Internal Medicine (GIM) is comprised of highly Dr. Mim Ari Dr. Nabil Abou Baker • Anna Volerman Beaser, MD – Recipient of the 2017 • Patricia Kurtz, MD – Recipient of the talented faculty dedicated to providing exceptional clinical care, teaching and educational program leadership, and con- Dr. John Flynn Community Service & Advocacy Award, Midwest Medical & Biological Sciences Alum- Dr. Milda Saunders Society of General Internal Medicine (SGIM) ni Association’s Gold Key Award ducting impactful research addressing health disparities. The Section is home to several outstanding academic centers Dr. Elizabeth Tung • Amber Pincavage, MD – Recipient of the 2017 • Milda Saunders, MD, MPH – Recipient of the including the MacLean Center for Clinical Medical Ethics, Bucksbaum Institute for Clinical Excellence, Chicago Center for Clinician Educator Award, Midwest SGIM Department of Medicine 2018 Diversity Award

Diabetes Translation Research, and the Center for Chronic Disease Research and Policy. • Deborah Burnet, MD, MAPP – Recipient of • Jason Alexander, MD – Appointed as the Biological Sciences Division’s 2018 Bucksbaum Junior Faculty Scholar In FY18, several GIM faculty were recognized of medicine, studies and cares for patients with local schools to improve health for children with The Primary Care Group (PCG) serves as the prima- Community Service Senior Award for their outstanding academic contributions: chronic kidney disease, to decrease disparities in asthma and to decrease obesity through healthy ry training site for over 130 Medicine and Medi- • Neda Laiteerapong, MD, MSCP – Appointed Marshall Chin, MD, MPH, was elected to National this population. Elizabeth Tung, MD investigates nutrition and exercise in partnership with Pilot cine-Pediatrics residents, as well as our Pritzker • Wei Wei Lee, MD – Recipient of the Bi- as Bucksbaum Junior Faculty Scholar Academy of Medicine for outstanding research effects of community violence on health outcomes. Light, a collaborative of Chicago’s elite chefs. Drs. medical students. Jennifer Rusiecki, MD, MS led ological Sciences Division’s 2018 Dis- in diabetes, and Vineet Arora, MD, MAPP was Miller and Burnet lead the UC Institute for Trans- development of the internal medicine residency tinguished Educator Junior Award • Arshiya Baig, MD, MPH – Appointed as Fellow of named as the 2018 recipient of the Department In FY18, GIM faculty were successfully awarded lational Medicine Community Cluster, partnering curriculum in women’s health. Dr. Rusiecki worked the Academy of Distinguished Medical Educators of Medicine’s Arthur Rubenstein Faculty Men- approximately $4.1M in research funding. New with the Chicago Department of Public Health effectively with interdisciplinary colleagues to torship Award. Six GIM faculty were named to grants include a NIH K24 career development and colleagues city-wide to promote research to build the PCG Women’s Health Clinic, integrating the 2018 “Top Doctors” list by Chicago magazine: award to Dr. Arora to provide structured men- improve Chicago’s health. Under direction of Drs. long acting reversible contraception including DURING THE PAST YEAR, SECTION OF Drs. Burnet, Diane Altkorn, Kamala Cotts, Mindy torship to trainees working on improving sleep Huang and Laiteerapong, the Center for Chronic IUDs and contraceptive implants (Nexplanon) GENERAL INTERNAL MEDICINE INVESTIGATORS: Schwartz, Mark Siegler, and Monica Vela. health for patients transitioning from hospital to Disease Research and Policy held its 5th annu- in primary care. Dr. Rusiecki also led a 12-week home. Arshiya Baig, MD, MPH received a five-year, al symposium, focused on reforming medicaid, training series through Project ECHO, a video-con- • Found that the risk of severe hypoglycemia and • Described the impact of a scholarly con- The Section welcomed five new faculty in FY18. $1.8 million grant from the Department of Health featuring Dr. William Golden, Arkansas Medicaid ference CME platform for regional primary care achieved glycemic control is essentially the same centration program on student interest John Flynn, MD, professor of medicine, a general and Human Services (DHHS) Office of Minority Medical Director and other national speakers. physicians caring for underserved populations. for basal insulin analogs as the much less expen- in career-long research (Wolfson, Aro- internist and rheumatologist, joined the Biological Health to improve diabetes care for low-income sive NPH insulin (Lipska, Huang , et al., JAMA, 2018) ra, et al., Academic Medicine, 2017) Sciences Division as the new Chief Physician and racial and ethnic minority patients, and Dorianne Under the direction of Lisa Vinci, MD, MS the The MacLean Center for Clinical Medical Ethics Dean for Clinical Affairs after serving as Associ- Miller, MD received a 3 year, $1M DHHS grant to Primary Care Group cared for approximately program led by Mark Siegler, MD has trained • Found that individualizing glycemic targets can • Reported on the impact of sleep in hos- ate Dean and Executive Medical Director for the improve screening and management of patients 25,000 patients, providing approximately 55,000 more than 500 clinical ethicists including 350 save over $13,000 per patient annually due to pitalized older adults (Stewart, Aro- Clinical Practice Association at Johns Hopkins with serious mental illness in primary care. patient encounters during FY18, and GIM is actively physicians since its inception in 1981. This year’s lower medication costs (Laiteerapong, Huang ra. Sleep Medicine Clinics, 2018) University. Nabil Abou Baker, MD, assistant supporting the expansion of the UCM primary MacLean Center lecture series focused on et al., Annals of Internal Medicine, 2017) professor of medicine, trained in both internal GIM faculty are implementing novel community- care infrastructure throughout the South Side. “Ethical Issues in Violence, Trauma, and Trauma • Demonstrated cost-effectiveness of con- medicine and pediatrics, focuses on improving based research and education to address health The integrated Behavioral Medicine Unit, led by Surgery,” co-directed by Dr. Siegler and Selwyn • Examined early winners and losers in dialysis tinuous glucose monitoring for adults pediatric-adult transitions of care for children disparities. Drs. Chin, Baig, Scott Cook, Elbert Huang, Dr. Laiteerapong, supports primary care patients Rogers, MD, UCM Trauma Chief. Now in its fourth center pay-for-performance (Saunders, Lee, with type 1 diabetes (Wan, Skandari, Minc, with chronic illness, such as sickle cell disease. Neda Laiteerapong, Monica Peek and Monica Vela working on healthy behavior change and managing year, the LUCENT Primary Care Program (Leading Chin, BMC Health Services Research, 2017) Huang, et al., Diabetes Care, 2018) Mim Ari, MD, assistant professor of medicine, has lead an initiative to improve shared decision making conditions such as depression and anxiety. Under Urban Primary Care Education and Transfor- special expertise in opioid use disorder, and with between clinicians and LGBTQ patients of color. Drs. the direction of Irsk Anderson, MD, the inter-profes- mation) led by Drs. Burnet and Volerman trains • Developed and validated a short-form safety George Weyer, MD, is leading efforts to advance Huang and Laiteerapong study diabetes outcomes sional Anti-Coagulation Management Service brings and supports primary care residents and faculty net medical home scale (Nocon, Gunter, Gao, our primary care practice and teaching to address and cost-effectiveness in patients throughout pharmacists into the primary care setting, and as they develop leadership skills and imple- Lee, Chin, Health Services Research, 2017) this issue. Milda Saunders, MD, assistant professor the US. Drs. Burnet and Anna Volerman work with trains medical and pharmacy students side by side. ment practice-based innovation projects.

2018 Annual Report 27 Professors: SECTION OF Yoav Gilad, PhD (Chief) DURING THE PAST YEAR, SECTION OF Dan Nicolae, PhD GENETIC MEDICINE INVESTIGATORS: Genetic Medicine Associate Professors: • Demonstrated the importance of microbial signals • Determined the genetic basis of anthracycline-car- Luis Barreiro, PhD in the development of pre-leukaemic myelopro- diotoxicity by molecular response quantitative liferation prompting new lines of investigation trait loci mapping in induced cardiomyocytes Assistant Professors: that may profoundly affect the prevention and which could potentially lead to accurate pre- Anindita Basu, PhD management of haematopoietic malignancies dictions of a patient’s response to a particular Mengjie Chen, PhD (Meisel, Jabri, Barriero, et al., Nature, 2018) chemotherapy drug to personalize their cancer Hae Kyung Im, PhD treatment (Knowles, Gilad, et al., eLife, 2018) Yang Li, PhD • Developed a new RNA splicing approach, Leaf- Barbara Stranger, PhD Cutter, to study sample and population vari- • Developed a new method to accurately estimate ation in alternative splicing that allows for the association between gene expression and Section Administrator: the discovery more sQTLs and improves the DNA methylation in tumor samples (Sun, Lin, Ann Leu interpretation of disease-associated variants Chen, et al., Nucleic Acids Research, 2018) Dr. Yoav Gilad (Li, Pritchard, Im, et al., Nature Genetics, 2018) • Developed methods to leverage GTEx resources • Applied the phylogenetic scan test for in- and identify target genes to guide drug discovery, vestigating cross-group differences in treatment, and prevention strategies (Barbeira, microbiome compositions using the Dir- Nicolae, Im, et al., Nature Communications, 2018) ichlet-tree multinomial model (Tang, Nicolae, et al., Annals of Applied Statistics, 2018) Dr. Chen and Dr. Basu

Under the leadership of Yoav Gilad, PhD, the Section of Genetic Medicine made significant progress in its quest to become a leader in translational genetic research at the University of Chicago in FY18. This includes continued expansion of the computational and statistical genetics programs with the recruitment of Dr. Luis Barreiro Dr. Yang Li two additional faculty.

Joining the Section of Genetic Medicine in FY18 processes. Dr. Li studies how dysregulation of of Anindita Basu, PhD to evaluate experimen- were Luis Barriero, PhD, associate professor of these processes play roles in complex disease. tal replicability of high-throughput single cell medicine and Yang Li, PhD, assistant professor A second focus of his work is the use of state- RNASeq for unbiased cell-type classification. of medicine. Dr. Barreiro’s research is focused of-the-art genomics tools, such as single-cell on understanding how natural selection has RNA-sequencing, to understand cellular com- Section investigators are also among leaders of contributed to the evolution of our species and position and function in disease progression. the NIH’s Genotype Tissue Expression project, to which extent past selection events impact a large effort to build a comprehensive atlas of present-day susceptibility to disease. He studies The Section’s research portfolio totaling $4.5M genetic effects on gene expression across the the genetic basis of differences in immune included the addition of 4 new NIH awards in human body. In particular, Barbara Stranger, PhD response among different individuals and FY18. Dr. Gilad successfully acquired 3 NIH R01s leads the working group focused on sex differenc- human populations as well as the phenotypic to further his efforts to characterize regulatory es at the gene expression level. Her laboratory is evolution of immune responses in primates. Dr. noise in single cell RNA sequencing, to charac- characterizing sexual dimorphism at the transcrip- Li’s research lies at interface of genetics, gene terize and map gene regulatory robustness in tome level within and between tissues, considering regulation, and disease. A large part of his work cardiomyocytes and to study gene regulatory both gene-level and transcript-level differences, aims to dissect the role of genetic variation on noise in differentiated cardiomyocytes using and characterizing tissue specificity of these gene regulation at multiple levels. In partic- single cell technology to identify novel CVD patterns. The affected biology is inferred through ular, he develops computational approaches risk loci. Mengie Chen, PhD was also awarded characterization of dimorphic gene functions, to study genetic effects on gene regulatory an NIH R01 focused on advanced statistical implicated functional pathways, and relationship mechanisms that have so far been under-ap- methods for single cell RNA sequencing. Other to disease. Her laboratory has also characterized preciated. These include RNA splicing, co-tran- extramural funding include a grant from the the extent to which the genetic basis of gene scriptional dynamics, and post-transcriptional Chan Zuckerberg Initiative to support the work expression differs between males and females.

2018 Annual Report 29 SECTION OF Dr. Vokes with Dr. Monica Malec

Geriatrics & Dr. Polonsky, Dr. Soltani and Palliative Medicine Dr. Vinci with Dr. Shellie Williams

Under the direction of the newly appointed chief, Stacie Levine, MD, the Section Dr. Stacie Levine of Geriatrics & Palliative Medicine (GPM) continued its tradition of excellence across the clinical, research and educational missions. In FY18, the Section welcomed Michelle Martinchek, MD and Sandy Tun, MD, assistant professors Accomplishments, Highlights and Discoveries: of medicine, to the faculty. Dr. Martinchek’ s academic interests are focused on • Daniel Brauner, MD & Stacie Levine, MD – Named American Academy of Hospice and Pallia- • Shellie Williams, MD – Recipient of the Biological as Top Doctors by Chicago magazine tive Medicine and accepted as a Fellow in Sciences Division’s Distinguished Community frailty assessment of geriatric patients with a focus on solid organ transplan- the Drexel University Amerigen Executive Service and Advocacy Award; appointed as a • Megan Huisingh-Scheetz, MD – Recipient of the Leadership in Academic Medicine program Junior Faculty Scholar in the Bucksbaum Institute tation while Dr. Tun’s expertise lies in the areas of advance care planning and 2018 Best Abstract Award (Clinical Research) for Clinical Excellence, and selected for the at the Department of Medicine Research Day • Monica Malec, MD – Recipient of the 2018 Tideswell National Leadership Development community based outreach. Department of Medicine Postgradu- Program in Geriatric Medicine • Lauren Gleason, MD – Selected to serve ate Teacher of the Year Award As the largest independent geriatrics & palliative Thompson, MD and Megan Huisingh-Scheetz, MD on the Public Education Committee for • Sandy Tun, MD – Accepted into the MERITS medicine section/division in Chicago, GPM de- - Co-Directors) continues to provide comprehen- Dr. Michelle Martinchek Dr. Sandy Tun the American Geriatrics Society • Charles Rhee, MD – Appointed as Chair Elect Faculty Scholars Program veloped several new initiatives within its clinical sive geriatric assessment and frailty evaluations for the Congestive Heart Failure Special programs in FY18 including the addition of an for vulnerable older patients as well as serve • Stacie Levine, MD – Appointed as Chair for Interest Group of the American Acade- embedded geriatrics clinic in transplant nephrol- as a platform for research and teaching efforts. the Workforce and Leadership Development my of Hospice and Palliative Medicine ogy and a palliative medicine clinic in surgical The Specialized Oncology Care & Research in program using smart voice to assist homebound Strategic Coordinating Committee for the oncology led by Drs. Martinchek and Tun, respec- the Elderly (SOCARE) clinic (Selina Chow, MD and older adults and their caregivers in promoting tively. Lauren Gleason, MD continued to work with James Wallace, MD - Co-Directors) remains an long-term rehabilitation and socialization. Teresita Hogan, MD (Section of Emergency Medi- integral centerpiece to geriatric oncologic care cine) to improve the evaluation and management in Chicago. New in FY18 was the addition of a In the educational realm, the Hospice and DURING THE PAST YEAR, SECTION OF of older adults who fall, and is a recent recipient pharmacist-driven Hypertension Management Palliative Medicine Fellowship (Charles Rhee, MD- Professors: Clinical Associates: GERIATRICS & PALLIATIVE MEDICINE INVESTIGATORS: of a funding by the Women’s Board at Univer- Service under the direction of Tia Kostas, MD. Program Director) continues to attract excellent Stacie Levine, MD – Chief Selina Chow, MD sity of Chicago and Academy of Distinguished candidates from across the country with over • Analyzed the relationship between phys- • Developed a rules-based algorithm that identified Medical Educators in support of this work. Research efforts by GPM faculty and staff continue 60 applicants in FY18. The Geriatrics Fellowship Associate Professors: Secondary ical activity and frailty among U.S. older those with the greatest risk of death among a poor to be supported by a variety of external sources. Program, led by Dr. Thompson, also attracted top Daniel Brauner, MD Appointments: adults based on hourly accelerometry data prognosis patient group (Bestvina, Polite, Chow, The inpatient and ambulatory Oncology Palliative Dr. Thompson is the principal investigator of a graduates from the internal medicine residency Katherine Thompson, MD, MA Stacy Lindau, MD, MPH (Huisingh-Scheetz, et al., Journals of Ger- Malec, et al., Journal of Palliative Medicine, 2018) Medicine Programs continue to grow steadily HRSA-funded Geriatric Workforce Enhancement class. Dr. Levine successfully renewed the Inter- Tamara Konetzka, PhD ontology, 2018 (Editor’s Choice Article)) under the direction of Monica Malec, MD who Program which created the South Side Healthy disciplinary Palliative Medicine Training Program Assistant Professors: • Contributed to the Handbook of Geriatric As- is leading the first integrated mesothelioma Aging Resource Experts (SHARE) Network. In grant with funding from the Coleman Foundation Lauren Gleason, MD, MPH Section Administrator: • Conducted a feasibility study describing a sessment 5th edition with the chapter entitled program in palliative medicine in the United FY18, Dr. Kostas received a HRSA Primary Care in FY18. Within the Pritzker School of Medicine, Dr. Megan Huisingh-Scheetz, MD, MPH Bradford Lane mixed-methods analysis of nurses’ educational “Emergency Department Assessment at the States. The Cardiac Palliative Service (Charles Medicine and Dentistry Career Development Kostas was appointed as the director of the MS1 Tia Kostas, MD needs and barriers to continuing education in Time of Hospitalization” (Hogan, Levine, 2018) Rhee, MD - Director) has seen growth as it pro- Award to study primary care medication man- Longitudinal Program and was inducted as a fel- Monica Malec, MD a for-profit skilled nursing facility in an un- vides support to patients with advanced heart agement for vulnerable populations, and Dr. low in the Academy of Distinguished Medical Ed- Michelle Martinchek, MD derserved, urban environment and proposed failure, including patients with left ventricular Huisingh-Scheetz was the recipient of a NIH ucators. Shellie Williams, MD continues to direct Charles Rhee, MD mechanisms to overcome barriers including assist devices. Within the outpatient programs, Chicago Center for Diabetes Translation Research the Geriatrics and Aging through Transitional En- Sandy Tun, MD ECHO training and an onsite nurse educator the nationally recognized SAFE Clinic (Katherine Pilot Award to develop a technology-based vironments (GATE) Program for medical students. Shellie Williams, MD (Thompson, et al., Geriatric Nursing, 2018)

2018 Annual Report 31 SECTION OF Professors: Instructors: Walter Stadler, MD (Chief) Olwen Hahn, MD Emily Curran, MD Michael Bishop, MD Dezheng Huo, MD, PhD Michael Drazer, MD+ Hematology & Oncology Suzanne Conzen, MD Justin Kline, MD James Godfrey, MD+ Christopher K. Daugherty, MD John Moroney, MD Steven Maron, MD M. Eileen Dolan, PhD Rita Nanda, MD Randy Sweis, MD Gini F. Fleming, MD Olatoyosi M. Odenike, MD Thomas F. Gajewski, MD, PhD Peter O’Donnell, MD Clinical Associates: Lucy A. Godley, MD, PhD Blase N. Polite, MD, MPP Andrea Amico, MD Harvey M. Golomb, MD Angela Stoddart, PhD* Sunila Narula, MD Dr. Jagoda Jasielec Philip Hoffman, MD Michael J. Thirman, MD Brooke Phillips, MD Dr. Chih-Yi (Andy) Liao Andrzej Jakubowiak, MD, PhD Shayan Rayani, MD Dr. Steven Maron Hedy L. Kindler, MD Assistant Professors: Ardaman Shergill, MD Dr. Alexander Pearson Richard A. Larson, MD Christine Bestvina, MD+ Grace Suh, MD Dr. Randy Sweis Michelle M. Le Beau, PhD Daniel Catenacci, MD, PhD Samir Undevia, MD Mark Lingen, DDS, PhD Jane Churpek, MD Dr. Walter Stadler Olufunmilayo Olopade, MD Jagoda Jasielec, MD Part Time Faculty: Jyoti Patel, MD Satyajit Kosuri, MD Imo Akpan, MD Mark J. Ratain, MD Angela Lager, MD Mark Kozloff, MD Sonali M. Smith, MD Chih-Yi (Andy) Liao, MD Under the direction of Walter Stadler, MD the Section of Hematology/Oncology continues to push the boundaries with Wendy Stock, MD Tanguy Lim-Seiwert, MD Section Administrator: sive Cancer Center grant (Michelle Le Beau, PhD Everett Vokes, MD Hongtao Liu, MD, PhD Jerry Schissler impactful contributions in clinical medicine, cancer research, and in training the next generation of hematologists and - PI) for years 43-47. Other new grants included a Amittha Wickrema, PhD Jason Luke, MD R25 to Eileen Dolan, PhD to establish an inno- Akash Patnaik, MD *Research track faculty oncologists. Among the many accomplishments this past year, most notable were national and institutional faculty vative program – Chicago EYES on Cancer – for Associate Professors: Alexander Pearson, MD, PhD +New FY19 faculty underrepresented high school students and Andrew Artz, MD Peter Riedell, MD recognition, the recruitment of three junior faculty, the successful renewal of the Comprehensive Cancer Center support undergraduates, and high school educators who Joseph M. Baron, MD Russell Szmulewitz, MD serve underrepresented students from the South Kenneth Cohen, MD Yonglan Zheng, PhD* grant, and the FDA’s approval of CAR-T cell therapy for use at University of Chicago Medicine (UCM), making it the first Side of Chicago, and a R13 to Dr. Olopade to lead new frontiers in the diagnoses and treatment of site in Illinois to offer this pioneering treatment for cancer. inherited cancer syndromes. Jason Luke, MD was Accomplishments, Highlights and Discoveries: the recipient of a Department of Defense award to On July 1, 2017 Sonali Smith, MD and Thomas basic and translational science research related MD - Director), treated 169 patients, of which 28 study genomic and commensal variants associated • Michael Bishop, MD; Hedy Kindler, MD; Jyoti Patel, • Richard Larson, MD – Recipient of the Gajewski, MD, PhD were honored with named to why head and neck cancers develop treatment received either standard or investigational CAR-T with immunotherapy response and resistance in MD; and Blase Polite, MD – Elected as Fellows Richard L. Schilsky Cancer and Leukemia professorships. Dr. Smith, the Elwood V. Jensen resistance. Chin-Yi (Andy) Liao, MD focuses his therapies. In other highlights, the Section con- cancer patients. Career development awards were of the American Society of Clinical Oncology Group B Achievement Award Professor, is an internationally recognized expert efforts on developing novel therapeutic strate- tinued its integration of Silver Cross Hospital and awarded to Alexander Pearson, MD, PhD focused on in lymphoma who has made outstanding con- gies for patients with gastrointestinal cancers, Orland Park into the oncology network, with an a mathematical modeling approach to combination tributions to the field through her clinical care, focusing on cholangiocarcinoma and neuroen- overall 11% growth rate in outpatient visits across therapy development in head and neck cancer, and DURING THE PAST YEAR, SECTION OF education and clinical research. Dr. Gajewski, docrine cancers. Jagoda Jasielec, MD has special the network. Also, under the direction of Blase Paul Geeleher, MD to develop novel computational the inaugural AbbVie Foundation Professor, is a expertise in multiple myeloma and lymphoma. Polite, MD, the Medicare Oncology Care Model, a approaches for pharmacogenomic discovery. HEMATOLOGY & ONCOLOGY INVESTIGATORS: pioneer in the field of cancer immunotherapy Also joining the Section were two instructors: standardized care pathway and value based mod- who has taken novel approaches to generate Steven Maron, MD and Randy Sweis, MD. el to improve patient centered care, decrease hos- The Section continued to expand its clinical • Identified variability in the stool microbiome • Discovered novel germ line leukemia predis- improved understanding and new immunother- pitalization, and decrease emergency room use, trial activity, accruing 1068 patients at UCM and as a major predictor of PD1 pathway direct- position syndromes (Drazer, Goldey, Daugh- apies for the treatment of cancer. Other faculty Within the clinical programs, the Section was was successfully rolled out, and the ASCO quality throughout the network into therapeutic trials. ed immunotherapy efficacy (Matson,Gajew- terty, Churpek, et al., Blood Advances, 2018) recognized for their outstanding contributions: once again recognized by USNWR as one of the initiatives (QOPI) were integrated across all local Under the direction of Kenneth Cohen, MD and ski, Alegre, Luke, et al., Science, 2018) Wendy Stock, MD was named as the Researcher of top cancer programs in the nation (August 2018) and network sites. In new clinical initiatives, Olwen Hahn, MD the Section continues to run • Provided new insights to further the understanding the Year from the Leukemia-Lymphoma Society; and over two dozen faculty were named as “Top Dr. Godley along with Tamara Polonsky, MD and a highly successful fellowship program. The 7 • Elucidated the interaction between clonal and therapeutic targeting of genomic heteroge- Olufunmilayo Olopade, MD was the recipient of Cancer Doctors” by Chicago magazine (January Jeanne DeCara, MD (Cardiology) started a trans- fellows selected annually typically come from the hematopoiesis and the microbiome to explain neity in gastro-esophageal cancer (Pectasides, the Order of Lincoln Award, the State of Illinois’ 2018). In FY18, the Section conducted over 48,000 lational clinic focused on clonal hematopoiesis. highest ranked residency training programs. For the association of leukemogenesis and cardio- Catenacci, et al., Cancer Discovery, 2017); (Maron, highest honor; Michelle LeBeau, PhD received outpatient visits, accomplished largely as a result FY18, over 80% of the graduating fellows are start- vascular diseases with this age related phenom- Catenacci, et al., Cancer Discovery, 2018) and the 2018 Department of Medicine’s Distinguished of enhanced scheduling and operations under The Section maintains a very strong and success- ing their careers with an academic affiliation and enon (Meisel, Jabri, Godley, et al., Nature, 2018) (Wong, Bass, Catenacci, Nature Medicine, 2018) Service Award; and Jane Churpek, MD was the the direction of Olwen Hahn, MD. Noteworthy ful program in basic, translational and clinical one is extending her laboratory training as a phy- recipient of the Biological Sciences Division was the approval of CAR-T cell therapy for use at research. In FY18 section faculty were awarded sician scientist, reflecting success in the strategic • Elucidated the role the glucocorticoid receptor • Advanced the use of clinical pharmacology and Distinguished (Junior) Investigator Award. UCM as the first center in the Chicago metro- approximately $19.5M in total costs grant funding goal of training future leaders in oncology. Several as a potential cancer therapeutic target (Kach, pharmacogenomics to optimize drug dosing and politan area to have this therapy available as a coupled with an additional $23M in clinical trial fellows and junior faculty and their mentors have Conzen, Szmulewitz, et al., Molecular Cancer decrease toxicity (Szmulewitz, Ratain, Stadler, In FY18, three assistant professors joined the standard of care. To that end, the cellular and earnings. Most noteworthy was the competitive earned external training awards in FY18 includ- Therapeutics, 2017), and (West, Conzen, Flem- et al., Journal of Clinical Oncology, 2018). Section. Alexander Pearson, MD, PhD performs stem cell transplant program (Michael Bishop, renewal of the University of Chicago Comprehen- ing Steve Maron, MD and James Godfrey, MD. ing, et al., Clinical Cancer Research, 2018)

2018 Annual Report 33 SECTION OF Professors: Instructor: David Meltzer, MD, PhD (Chief) Micah Prochaska, MD Tokhanh Nguyen, MD Robert Gibbons, PhD Frances Puello, MD+ Hospital Medicine Clinical Associates Dragana Radovanovic, MD Associate Professors: and Scholars: Alexander Reisner, MD Jeanne Farnan, MD, MHPE Hatem Al Kassem, MD Edwin Rosas, MD Daniel Ash, MD+ Audrey Tanksley, MD Assistant Professors: Rizma Bajwa, MD Eisha Wali, MD+ Brian Callender, MD Lihua Bao, MD+ Chang Yang, MD Matthew Cerasale, MD Nicole Bendin, MD Madhu Yarlagadda, MD Dr. Thomas Chen Ishanu Chattopadhyay, PhD Grace Berry, MD Dr. Matthew Cerasale, Thomas Chen, MD Christina Boutsicaris, MD Section Administrator: Dr. Elizabeth Murphy Anton Chivu, MD Bryan Campbell, MD Rebecca Schedin, MA Dr. Andrew Schram Vincent DiMaggio, MD+ Kwang Jin Choi, MD Dr. Anshu Verma Cheng-Kai Kao, MD Tatvam Choksi, MD +New FY19 faculty V. Ram Krishnamoorthi, MD Dana Edelson, MD Dr. David Meltzer Shannon Martin, MD Lizhu Gao, MD Elizabeth Murphy, MD Sarah Haroon, MD Gregory Ruhnke, MD, MS, MPH David Hwang, MD+ Andrew Schram, MD Christine Jun, MD Dr. Vokes with Joyce Tang, MD Frederick Jung, MD+ Jeanne Farnan, MD Anshu Verma, MD Navneet Kaur, MD John Yoon, MD Anne Kelly, MD Ehtasham Khattak, MD Sladjana Mitric, MD Under the leadership of David Meltzer, MD, PhD, the Section of Hospital community based arts/culture program. New funding was also received which will extend the reach of Medicine is recognized for its innovative patient care, research and educational the Community Health Worker Program and Artful Living Program, and support patient engagement and Accomplishments, Highlights and Discoveries: programs that are pushing the boundaries of clinical practice and training interviewing to better explore and address patients’ medical and social needs. Nationally, the CCP pro- • Anton Marius Chivu, MD – Appointed to • Shannon Martin, MD – Inducted into future generations of physicians in hospital medicine. gram was recognized in the New York Times magazine Society of Hospital Medicine Practice Academy of Distinguished Medical Educators (May, 2018) with a front page story entitled “Trying Management Committee and selected as American Board of Medical In FY18, five junior faculty joined the Section: care delivery and quality. These include establishing to Put a Value on the Doctor-Patient Relationship”. Specialties Visiting Scholar for 2018-2019 Matthew Cerasale, MD; Thomas Chen, MD, PharmD; the first hospital medicine oncology service director • Jeanne Farnan, MD – Recipient of the Department Elizabeth Murphy, MD; Andrew Schram, MD, MBA; role (D. Radovanovic, MD) and model for hospital The Section’s research portfolio consisted of $5.6 school, residency and at the post graduate level. of Medicine 2018 Pre-clinical Teacher of • Cheng-Kai Kao, MD – Named as UCM’s and Anshu Verma, MD. Drs. Cerasale, Murphy and medicine service leadership roles, and the deploy- million in extramural funding in FY18. In addition to Leadership roles in the medical school include As- the Year Award Associate Chief Medical Information Officer Schram have interests focused on quality improve- ment of co-managed services with hematology/on- the new CCP funding noted above, Micah Prochaska, sociate Dean for Evaluation and Continuous Quality ment and operational efficiencies related to caring cology and orthopedic surgery. In addition, the Sec- MD was awarded an NIH K23 to study the effect of Improvement (Jeanne Farnan, MD), the Global Health • Elizabeth Murphy, MD – Appointed to • Joyce Tang, MD – Recipient of the Biological for hospitalized patients. Dr. Chen is interested tion developed advanced IT- supported strategies to red blood cell transfusion on fatigue, activity and Scholarship and Discovery track (Brian Callender, Society of Hospital Medicine Academic Sciences Division 2018 Distinguished in the health disparities in the Asian population, optimize processes and outcomes, including an end- fatigability in hospitalized patients with anemia and MD), Director and Assistant Program Director of Hospitalist Committee Clinician (Junior) Award pharmacogenomics as well as medication recon- of-shift hand-off tool, and an innovative and award Robert Gibbons, PhD was awarded supplemental the Internal Medicine Residency Program at Mercy ciliation, cost effective prescribing, and quality winning Virtual Multidisciplinary Rounds Navigator. funds from NIH related to his R01 project to develop Hospital (John Yoon, MD), director of the MD/PhD improvements to decrease costs of care and improve computerized adaptive testing of suicidality in LGBT Program in the Social Sciences and chair of the Com- DURING THE PAST YEAR, SECTION OF health outcomes. Dr. Verma focuses her efforts in FY18 was also a major year for the Section’s Medi- young adults. Dr. Meltzer successfully renewed the mittee on Clinical and Translational Science (David HOSPITAL MEDICINE INVESTIGATORS: the Comprehensive Care Physician (CCP) program. care-funded Comprehensive Care Program (CCP), NIH T35 Short-Term Aging-related Research (STAR) Meltzer, MD, PhD). New educational initiatives in FY18 a program that seeks to improve care and lower program which has provided summer training include a extramural teaching program on ethics Section faculty care for some of the most medical- costs through continuity of care. FY18 highlights for in basic, clinical, and social science research for directed by Dr. Yoon through the Hyde Park Institute. • Determined that personal exposure to role • Described a model of attending remote ly complex patients admitted to the University of the CCP program include the recruitment of an APN Pritzker medical students to inspire and prepare Additionally, the Hyde Park Institute and Chicago models in medical school is an important EHR use for resident supervision, and Chicago Medicine (UCM). During the past academic to expand home care services and enroll Chicago them to pursue careers in aging research. Dr. Meltzer Translational Medicine Program (CMTP) award funded predictor of residency training in that role quantified the frequency and magnitude of year, the Section continued to grow, employing over patients in managed care contracts. Also noteworthy was also awarded a new grant from the Laura by the Biological Sciences Curricular Division and model’s specialty (Yoon, et al., Journal of use (Martin, Farnan, Meltzer, et al., Journal 40 hospitalists and a team of 6 advanced practice was successful completion of Phase I of the Robert and John Arnold Foundation to evaluate critical co-directed by Dr. Meltzer and Dr. Prochaska, provides Graduate Medical Education, 2018) of Graduate Medical Education, 2017) nurses and physician assistants who provide care to Wood Johnson Foundation funded Comprehensive time intervention in a criminal justice setting. a structured longitudinal mentoring program in a growing volume of patients (110+ per day) at UCM. Care, Community and Culture Program (C4P) study clinical and translational medicine for University of • Showed an association between anemia and • Found no significant association between Under the leadership of Anton Marius Chivu, MD, Di- including establishing a research center, hiring a Hospital Medicine faculty continue to be actively en- Chicago undergraduates in the Biological Sciences fatigue in hospitalized patients (Prochaska, groundwater lithium exposure and the risk of rector of Clinical Operations, several major improve- community health worker, implementing systematic gaged in teaching and training of the next generation working with faculty on biologically oriented research Meltzer, et al., Journal of Hospital Medicine, 2017) bipolar disorder or dementia in the United States ments were made to support excellence in clinical screening of unmet social needs and establishing a of physicians and physician scientists at the medical that relies on the Section’s research infrastructure. (Parker, Gibbons, et al., JAMA Psychiatry, 2018)

2018 Annual Report 35 SECTION OF Professors: David Pitrak, MD (Chief) Jonathan Lio, MD Kathleen Mullane, DO, Pharm D Moira McNulty, MD+ Infectious Diseases Kenneth Pursell, MD Mai Pho, MD, MPH Renslow Sherer, MD Jennifer Pisano, MD and Global Health Stephen Weber, MD, MS Jessica Ridgway, MD Stephen Schrantz, MD, MPP Associate Professors: Jean-Luc Benoit, MD Section Administrator: Titus Daniels, MD, MPH James Jung John Schneider,MD, MPH +New FY19 faculty Assistant Professors: Andiruddha Hazra, MD+ Emily Landon, MD

Dr. David Pitrak Dr. Stephen Schrantz

Under the direction of David Pitrak, MD the Section of Infectious Diseases and portionately affected populations in healthcare set- (pre-exposure prophylaxis) against HIV infection Section of Infectious Diseases and Global Health tings at UCM and at 12 other sites on the south and among African American Women in Chicago. Dr. Pho Global Health has seen continued growth and expansion of clinical activities, west sides of Chicago. The program has resulted in continued her work on optimizing patient-oriented diagnosis of patients at an earlier stage of disease outcomes for chronic hepatitis C as part of her NIH clinical trials, research, educational activities, and service to the institution in and also reduced early AIDS-related deaths within 1 funded R00 award. She also received a CFAR admin- year of diagnosis. HIV testing also continued to ex- istrative supplement award for Prelink (pre-release FY18. The Section’s efforts in public health, particularly HIV care and prevention, pand at UCM in FY18 under the direction of Mai Pho, linkage) to HCV, HIV, and addiction services for MD, MPH. Dr. Schneider continued to make progress inmates prior to release from jail, and a NIH UG3 Accomplishments, Highlights and Discoveries: extend out into communities on both the south and west sides of Chicago and toward elimination of new HIV transmissions on program project that aims to ending transmission of the south side of Chicago through his cutting edge HIV, HCV, and STDs and overdose in rural commu- • Kathleen Mullane, DO – Elected as a Fellow of • Moira McNulty, MD – Recipient of a Third Coast across the state of Illinois to combat HIV, HCV, and drug addiction, and globally HIV prevention programs at the Village and at the nities of people who inject drugs (ETHIC). In clinical the American Society of Transplantation CFAR Pilot Award for her project “Implementing Howard Brown Health Center 55th Street Clinic. research, Kathleen Mullane, DO continued to con- the Next Generation of HIV Testing Strategies” in Greece and China. duct a number of clinical trials of new antimicrobial • Jessica Ridgway, MD – Co-chaired the 2017 Annual In FY18, the Section’s research portfolio continued agents, with many of her studies benefiting the im- Third Coast CFAR Symposium entitled “Bridging • John Schneider, MD, MPH – Published his 100th ar- to expand as well. New grants this year included munocompromised patients in the leukemia, stem the Disciplines to Understand HIV Transmission” ticle in the field of HIV prevention (Rusie, Schnei- In FY18 Stephen Schrantz, MD, assistant professor hensive HIV Care Program. In quality initiatives, a NIH R01 awarded to Dr. Schneider to guide and cell transplant, and solid organ transplant programs. held at Northwestern University in October 2017 der, et al., Clinical Infectious Diseases, 2018) of medicine and pediatrics, joined the Section. Dr. the UCM has continued to meet all its goals with transform the rapidly evolving public health imple- Schrantz’s work is focused on pediatric to adult respect to hand hygiene, central line associated mentation of molecular HIV surveillance based pre- In the educational arena, the Infectious Diseases transition of care for children with congenital bloodstream infections, and catheter associated vention interventions as a critical step towards HIV and Global Health Fellowship Program continues to or childhood acquisition of HIV infection. He is UTIs, and continues to combat C. difficile infec- elimination. Under the direction of Dr. Schneider, attract outstanding fellows, the majority from the DURING THE PAST YEAR, SECTION OF INFECTIOUS also working with colleagues in the Department tion in the hospital. These accomplishments by and with co-directorship by Dr. Pitrak and participa- Department’s internal medicine residency program. DISEASES AND GLOBAL HEALTH INVESTIGATORS: of Pediatrics to deliver post-partum care to the Infection Control Program (Emily Landon, MD tion by Jessica Ridgway, MD, the Section maintained The Wuhan University Medical Education Reform women with HIV and their exposed children. – Medical Director) contribute significantly to the its involvement in the Third Coast Center for AIDS (WUMER) Project, (Renslow Sherer, MD - Director), • Participated in two high profile clinical research • Developed and implemented an electronic UCM’s perennial A ratings from the Leapfrog Group. Research (CFAR) partnership with Northwestern now in its ninth year, continues to lead faculty studies that provided insights into new risk score to identify emergency department The Section continues to provide outstanding University, the AIDS Foundation of Chicago, the development, undergraduate curriculum improve- therapies for stem cell transplant recipients, patients who are potential candidates for consultative services 24/7 to ensure optimal and Within the Section, the Chicago Center for HIV Elim- CDPH, the Alliance of Chicago Community Health ment, residency training at Wuhan University and including use of an inactivated varicella vaccine preexposure prophylaxis (PrEP) care (Ridgway, timely management of serious infectious diseases ination (John Schneider, MD, MPH and David Pitrak, Systems, and the Center on Halsted, to reduce the has been greatly received by the China Higher Edu- (Winston, Mullane, et al., Lancet, 2018) and Schneider, et al., AIDS Patient Care STDS, 2018) and actively serves the oncology and transplant MD, Co-Directors) provides care for HIV-infected very high rate of new HIV infections among young cation Association. Jonathan Lio, MD has joined the the efficacy of letermovir for Cytomegalovirus programs by running an immunocompromised patients, as well as screening, prevention educa- minority MSM in Chicago. Other research highlights project and is assisting Dr. Sherer in program imple- prophylaxis (Marty, Ljungman, Maertens, • Found that severe sepsis outcomes depend host service, 7 days a week. In FY18, the Sec- tion treatment for pediatric HIV patients who are include extramural funding for Dr. Ridgway from mentation. Dr. Lio has been accepted into the MER- Dadwal, Duarte, Haider, Ullmann. Mullane, et on the patient’s health before infection tion enhanced its Outpatient Antibiotic Therapy transitioning to adult care, and post-partum care Gilead Sciences to develop rapid response team and ITS program to evaluate crowdsourcing in residency al., New England Journal of Medicine, 2017) and the degree of organ dysfunction af- Program (Jennifer Pisano, MD - Medical Director), for HIV-infected women and their exposed children. algorithmic HIV post-test counseling in high-volume education in Wuhan. Dr. Pisano completed the ter infection (Greenberg, Kress, Pitrak et al., a joint effort between the Antimicrobial Steward- With uninterrupted funding from the Chicago settings, and funding from the CDPH to utilize infor- MERITS fellowship and an educational program that • Developed and implemented a gold American Journal of Critical Care, 2018) ship Program, Pharmacy and the Section, with Department of Public Health (CDPH) since 2011, Dr. matics to identify patients with HIV who are out of developed an Antimicrobial Stewardship Educa- standard for entity resolution within the assistance of Paul Djurovich, PharmD, who Pitrak continues to focus his efforts on expanded care. Dr. Ridgway also received a CFAR administrative tional Toolkit aimed at improving trainee education sexually transmitted infection networks is also a key provider for the Section’s Compre- HIV testing and linkage to care (X-TLC) for dispro- supplement award to examine the barriers to PrEP on the topic of appropriate antimicrobial usage. (Schneider, et al., Scientific Reports, 2018)

2018 Annual Report 37 SECTION OF Accomplishments, Nephrology Highlights and Discoveries:

• Hatim Hassan, MD, PhD – Recipient of the Best Faculty Abstract Award (Basic Research) at the 2018 Department of Medicine Janet D. Rowley Research Day

• Michelle Josephson, MD – Named as a Bucksbaum Institute for Clinical Excellence Senior Faculty Scholar and awarded a 2018 Bucksbaum Institute Pilot Grant for her study entitled “Patient decision making regarding kidney transplant options: a needs assessment” Dr. Arlene Chapman • Benjamin Ko, MD – Elected as a Fellow in the Academy of Distinguished Medical Educator and also selected by the Pritzker School Dr. Hatim Hassan at 2018 Department of Medicine of Medicine as the recipient of the 2018 was the successful renewal of the NIH P01 grant Research Day LDH Wood Preclinical Teaching Award The Section of Nephrology continues its mission of developing innovative “Pathogenesis of Calcium Nephrolithiasis” (Elaine Worcester, MD - PI) for years 16-20. With funding • Nicole Stankus, MD – Recipient of the 2018 programs for the treatment of kidney diseases. Under the direction of Arlene from the University of Chicago Innovation Fund Professors: Assistant Professors: Department of Medicine’s Clinical Pro- and the New Venture Challenge, Hatim Hassan, Arlene Chapman, MD (Chief) Patrick Cunningham, MD ductivity Award for Procedure Activity Chapman, MD, FY18 was a productive and fruitful year for the Section with MD, PhD co-founded a startup company “Oxalo Fredric Coe, MD Hatim Hassan, MD, Ph.D. Therapeutics” to investigate the therapeutic po- Michelle Josephson, MD Benjamin Ko, MD • Bharathi Reddy, MD – Re-elected to the many accomplishments including the addition of a new faculty member, tential of oxalobacter formigenes-derived factors Elaine Worcester, MD Pratik Shah, MD Medical Review Board of the ESRD Network for hyperoxaluria, hyperoxalemia, and related Anna Zisman, MD 10 for a second 3 year term, and recipient the development of the faculty research seminar and the first annual Renal kidney stones. Dr. Chapman continued her work, Associate Professors: of the 2018 Department of Medicine’s in collaboration with investigators at University of Mary Hammes, DO Clinical Associate: Overall Clinical Activity Award Research Retreat on chronic kidney disease. Also noteworthy were the opening California-Davis, relating to the use of metabo- Orly Kohn, MD John Asplin, MD lomics for kidney diseases. Jay Koyner, MD, will Jay Koyner, MD • Anna Zisman, MD – Elected to the Research of the Section’s 5th outpatient dialysis unit and the successful renewal of the begin his work utilizing EMR-based risk predictors Rita McGill, MD Section Administrator: Dr. Pratik Shah on Calculus Kinetics (ROCK) Society designed for early identification of hospitalized Tipu Puri, MD, PhD Matthew Lagen NIH program project grant focused on kidney stone formation. patients likely to develop acute kidney injury. Bharathi Reddy, MD Nicole Stankus, MD In July 2017 Pratik Shah, MD, assistant professor The Renal Ambulatory Care Clinic (Anna Zisman, The Nephrology Fellowship Program (Anna Zisman, DURING THE PAST YEAR, of medicine, joined the Section. Dr. Shah’s work MD - Director) has continued to build a Compre- MD - Program Director, Ben Ko, MD - Associate Pro- SECTION OF NEPHROLOGY INVESTIGATORS: is focused on understanding risk factors for hensive Kidney Care program, adding nutritional gram Director) developed several new initiatives. BK viremia in kidney transplant recipients with services through Melanie Betz, RD, and social In FY18, a new conference, the “Director’s Corner”, Day, with fellows winning the 2018 National Kidney • Identified the urine pH difference between as potential therapeutic targets (Amin, a particular emphasis on HLA and BK viremia. work support through Akilah King for the complex was initiated where the Section and program Foundation “Controversies in Nephrology” debate normal men and women, demonstrating a link Hassan, et al., Kidney International, 2018) He is also interested in studying the role of gut patient population. Finally with the FDA’s approv- directors work with the clinical fellows on new under the mentorship of Orly Kohn, MD. Dr. Kohn, to GI alkali transport (Worcester, Coe, Bergsland, microbiota in infectious and immunological al of Tolvaptan (@Jynarque) for the treatment of case presentations. A monthly multidisciplinary in conjunction with Paul Chang, MD (Department American Journal of Renal Physiology, 2018) • Determined that capsulitis is an important complications after kidney transplantation. autosomal dominant polycystic kidney disease pathology conference is now a part of the Renal of Radiology), continued to train clinical nephrol- pathologic parameter in the evaluation of patients at high risk for progression to end Grand Rounds curriculum in conjunction with the ogy fellows on both transplant and native kidney • Reported a slower decline in the estimated kidney transplant biopsies with potential The Section’s joint venture with DaVita resulted stage renal disease, the UCM Polycystic Kidney Department of Pathology. Under the direction of Dr. biopsy through didactic sessions and specialized glomerular filtration rate (GFR) with the use diagnostic, prognostic, and therapeutic in the opening of a 5th outpatient dialysis unit, Disease Center of Excellence is now treating high Ko, a Second Year Tracks Program provides fellows training within the simulation center. Finally, Dr. of tolvaptan than with placebo in patients implications in the setting of T-cell- mediated Park Manor, under the direction of Rita McGill, risk patients with this drug for this condition. the opportunity to become subject matter experts Ko’s TREKS (Tutored Research and Education for with autosomal dominant polycystic rejection (Gallan, Chang, Josephson, MD. A 6th outpatient dialysis unit, Brighton Park, in four subspecialized areas of nephrology (Stones Kidney Scholars) program in conjunction with kidney disease (Torres, Chapman, et al., Cunningham, et al., Human Pathology, 2018) also opened July 2018. The four other Univer- The Section of Nephrology is proud of its diverse and Bones, Genes and Beans, Vascular Access and the American Society of Nephrology received New England Journal of Medicine, 2017) sity of Chicago-led DaVita-owned outpatient bench, translational and patient oriented in- Home Dialysis). This program resulted in a total funding for a second year. The TREKS program is • Developed a machine learning risk assessment dialysis units continue to deliver excellent vestigations in polycystic kidney disease, acute of 13 abstracts presented at various meetings, one of only two national programs which hosts • Found that reduced active intestinal oxalate tool for the prediction of acute kidney injury patient care. In FY18, the Stony Island Dialysis kidney injury, epithelial cell transport, growth, including the American Society of Nephrology and medical students from all over North America secretion contributes to the pathogenesis across all patients admitted to the hospital Unit was awarded the “DaVita Core Value Award and gene expression, and the pathophysiology the National Kidney Foundation’s clinical meetings, interested in nephrology for one week of intensive of obesity-associated hyperoxaluria (Koyner, et al., Critical Care Medicine, 2018) of Team” by the DaVita Physician Council. of kidney stone formation. Noteworthy in FY18 as well as the Department of Medicine’s Research study to foster careers as future nephrologists. suggesting proinflammatory cytokines

2018 Annual Report 39 SECTION OF Accomplishments, Highlights and Discoveries:

• Ayodeji Adegunsoye, MD – Received the • Edward Naureckas, MD – Appointed as the President Pulmonary/ I.M. Rosenzweig Junior Investigator Award of Medical Staff, UCM; and served as senior author from Pulmonary Fibrosis Foundation on CF Foundation Guidelines paper (Naureckas, Critical Care Medicine Annals of the American Thoracic Society, 2018) • Yun Fang, PhD – Recipient of the Department of Medicine Leif B. Sorensen Faculty Research Award • Jason Poston, MD – Named as Chair, Preclinical Curriculum, Pritzker School of Medicine and • Robert Guzy, MD, PhD – Recipient of the Senior Editor for American Thoracic Society Dr. Ayodeji Adegunsoye Dr. Bhakti Patel ASCI Young Physician-Scientist Award Review for Critical Care Boards, First Edition

• Kyle Hogarth, MD – Founder and president of • Mary Strek, MD – Recipient of CHEST the Society for Advanced Bronchoscopy Distinguished Educator Award

• John P. Kress, MD – Named as Chair, American • Esra Tasali, MD – Appointed as a standing Dr. Gökhan Mutlu Thoracic Society Critical Care Assembly member of NIH CHSB Study Section

• Babak Mokhlesi, MD – Appointed as President • Steven White, MD – Appointed as the Vice Chair for of Society of Anesthesia and Sleep Medicine Promotions and Appointments for the Department of Medicine, and a member of the American • Septimiu Murgu, MD – Recipient of the CHEST Thoracic Society Publications Policy Committee Distinguished Educator Award, and named as secretary treasurer (incoming vice president) of the American Association for Bronchoscopy and Interventional Pulmonology Under the leadership of Gökhan Mutlu, MD, the Section of Pulmonary and Critical Care Medicine continues to be Dr. Fang and Dr. Vokes recognized nationally for excellence in clinical medicine, impactful research and innovative educational programs. In DURING THE PAST YEAR, SECTION OF PULMONARY/ CRITICAL CARE INVESTIGATORS: FY18, two new faculty joined the Section: Bhakti Patel, MD, assistant professor, is a physician scientist who conducts Professors: Gökhan M. Mutlu, MD (Chief) Yun Fang, PhD • Discovered geographic variation in the • Published one-year outcomes in patients critical care outcomes research including mechanisms by which critical illness causes neuromuscular weakness. Ayodeji Edward Garrity, Jr., MD Laura Frye, MD management of US heart transplant candi- receiving helmet ventilation for ARDS (Patel, Jesse Hall, MD++ Robery D. Guzy, MD, PhD dates (Parker, Churpek, et al., Journal of the Wolfe, Hall, Kress, Critical Care Medicine, 2018) Adegunsoye, MD, instructor is a physician scientist whose research focuses on the interstitial lung diseases. John P. Kress, MD Renea Jablonski, MD+ American College of Cardiology, 2016) Alan Leff, MD++ Robert B. Hamanaka, PhD* • Was the senior author on the state of the art Among the clinical programs within the Section, from the Primary Ciliary Dyskinesia Foundation. particulate matter air pollution causes cardio- Babak Mokhlesi, MD Pamela J. McShane, MD • Wrote a review article on management guidelines on liberation from mechanical under the direction of Mary Strek, MD, the Inter- Kyle Hogarth, MD, the director of our bronchoscopy pulmonary disease. Ayodeji Adegunsoye, MD was Edward Naureckas, MD Bhakti Patel, MD of persistent thoracic airleaks (Du- mechanical ventilation (Kress, Chest, 2017) stitial Lung Disease (ILD) program has become a program led the efforts to make UCMC the first cen- awarded a Pulmonary Fibrosis Foundation grant to Julian Solway, MD Philip Verhoef, MD, PhD gan, Murgu, Hogarth, Chest, 2017) highly collaborative multidisciplinary program ter in Midwest to perform robotic bronchoscopy. study the impact of race on genetic predisposition Mary Strek, MD Krysta Wolfe, MD+ • Demonstrated the role of educational video on delivering outstanding clinical care to patients to honeycombing in pulmonary fibrosis. Robert Steven White, MD • Published a landmark study on African-Amer- CPAP compliance (Mokhlesi, Thorax, 2017) nationwide and internationally. In addition, our The Section continues to maintain a successful B. Hamanaka, PhD received an American Thoracic Instructors: ican Race and Mortality in Interstitial Lung team was one of the 10 finalists to compete in research program and continued to have a suc- Society Foundation award and the Respiratory Associate Professors: Ayodeji Adegunsoye, MD Disease (Adegunsoye, Churpek, Strek, Eu- • Demonstrated the role of FGF2 in pulmonary the IPF Catalyst Challenge. Catherine Bonham, cessful year securing extramural NIH support. Yun Health Association award to study the role of Remzi Bag, MD Cara Hrusch, PhD ropean Respiratory Journal, 2018) fibrosis. (Dulin, Guzy, Journal of Pathology, 2018) MD has established a sarcoidosis clinic, which Fang, PhD received two R01 awards to study the fibroblast metabolism in pulmonary fibrosis. Bohao Chen, PhD* Nathan Schoettler, MD, PhD+ is recognized by the Foundation for Sarcoidosis role of miRNA92A/PPAP2B signaling in endothelial Nickolai Dulin, PhD David Wu, MD, PhD+ • Discovered novel ILD phenotypes that im- • Discovered the correlation between T cell respons- Research and World Association for Sarcoidosis cell function and nanomaterial-based endothelial On the educational front, the Section’s faculty Kyle Hogarth, MD prove classification and prognostication es and outcomes in S aureus bacteremia. (Hrusch, and other Granulomatous Disorders. Laura Frye, cells specific delivery of miRNA inhibitor to treat continue to distinguish themselves in all domains John McConville, MD Clinical Associate: in patients with pulmonary fibrosis (Ade- Hall, Kress, Sperling, Verhoef, Critical Care, 2018) MD has founded the first benign airway disease atherosclerosis. Catherine Bonham, MD received of teaching and training. Jason Poston, MD was the Septimiu Murgu, MD Rekha Vij, MD gunsoye, Strek, Churpek, Chest, 2018) program in the Chicago area. Under the direction a K23 award to investigate the role of T cells in recipient of the Favorite Faculty Award from the Jason Poston, MD • Demonstrated changes in airway microbiome of Remzi Bag, MD, the Pulmonary Hypertension idiopathic pulmonary fibrosis. Steve White, MD re- Pritzker School of Medicine graduating students Anne Sperling, PhD Section Administrator: • Discovered how blood flow changes endothelial in atopic asthma (White, Microbiome, 2018) Program has received the 3-year extension on ceived an R34 award to study whether macrolides for the sixth time. The Section continues to recruit Esra Tasali, MD Elneda Boyd cell metabolism to drive endothelial dysfunc- its designation of Center of Comprehensive Care may mediate their beneficial effects in asthma outstanding fellows into our three fellowship tion (Wu, Hamanaka, Fang, Mutlu, Elife, 2017) from the Pulmonary Hypertension Association. via reversal of dysbiotic airway microbioata and a programs: pulmonary and critical care medicine, Assistant Professors: *Research faculty Under the direction of Pamela J. McShane, MD, UG1 as part of Chicagoland Metropolitan Asthma sleep medicine and interventional pulmonary Matthew Churpek, MD, PhD +New FY 19 Faculty • Discovered the role of PHGDH in pulmonary fibrosis the bronchiectasis program received the Adult Consortium. Gökhan M. Mutlu, MD renewed his R01 (IP). The Section successfully submitted AABIP Jessica Cooksey, MD ++Emeritus (Hamanaka, Guzy, Wu, Dulin, Mutlu, American Jour- Primary Ciliary Dyskinesia Center of Excellence to continue to study the mechanisms by which accreditation for their IP fellowship program. nal of Respiratory Cell and Molecular Biology, 2018)

2018 Annual Report 41 SECTION OF Rheumatology

Dr. Marcus Clark

Under the leadership of Marcus Clark, MD, the Section continued its tradition of clinical excellence, innovative research and outstanding clinical training focused on understanding autoimmunity with the goal of improving the care of those Section of Rheumatology DURING THE afflicted with diseases such lupus, rheumatoid arthritis, vasculitis and polymyositis. In the past year, Section faculty PAST YEAR, SECTION contributed to major advancements in the field of immunology that have the potential to translate into cutting edge Professors: Clinical Associate: OF RHEUMATOLOGY Marcus Clark, MD (Chief) Aimee Mayuga, MD INVESTIGATORS: treatments for those suffering from autoimmune and infectious diseases. Maria-Luisa Alegre, MD, PhD Michael Becker, MD++ Section Administrator: • Demonstrated that antibodies to influenza James Curran, MD Ann Leu neuraminidase are broadly protective in The Section maintains outstanding disease-fo- both innate and adaptive immunity. While the Sec- ogy, Immunity, Journal of Clinical Investigation, Sci- Leif Sorensen, MD, PhD++ humans. This finding opens new avenues for cused clinical programs that drive its reputation for tion is committed to autoimmunity, the research in ence Immunology and Science Translational Medicine. Patrick Wilson, PhD ++Emeritus the development of a universal influenza excellence in the treatment of rheumatic diseases. immunity has evolved to include innovative studies *Research faculty vaccine (Wilson and colleagues, Cell, 2018) Recent programs that continue to grow and gain relevant to influenza, the microbiome and cancer. On the educational front, the Section is very active Associate Professors: prominence are the Vasculitis Center (Anisha Dua, Indeed, by focusing on fundamental immunological in multiple training and teaching venues. Within Fotini Gounari, PhD • Identified novel signaling mechanisms controlling MD - Director) which launched last year and the mechanisms, the Section’s work provides insights the Rheumatology Fellowship Program, the Section Malay Mandal, PhD* antigen presentation in B cells (Clark and Lupus Center under the co-directorship of Drs. into the complex interplay between the immune continues to recruit top candidates to the program colleagues, Journal of Experimental Medicine, 2017) Kichul Ko and Kimberly Trotter. New to the Lupus system and disease. This year, Marisa Alegre, MD, PhD, from record numbers of applications. The fellowship Assistant Professors: Center is a lupus nephritis longitudinal study cohort led a successful effort to renew a NIH P01 grant to program was one of five chosen nationally to lead Anisha Dua, MD • Defined cardiovascular risk in gout patients treated supported by the Knapp Center for Lupus and study the role of infection in the stability of trans- an initiative to have fellows educate community Reem Jan, MD with febuxostat or allopurinol (Becker, White and Immunology Research. This cohort will be critical plantation tolerance. Fotini Gounari, PhD was award- providers on the early recognition and management Kichul Ko, MD colleagues, New England Journal of Medicine, 2018) for identifying clinical and immunological features ed a grant from the American Society of Hematology of lupus. Finally, the Section is home to the Medical Vladimir Liarski, MD of those patients at highest risk for progressive to understand how activation of the developmental Scientist Training Program (MSTP) which celebrated Kimberly Trotter, MD • Revealed that the commensal microbiome renal damage. Through the efforts of Drs. James signaling pathway, beta-catenin, can lead to genomic its 50th anniversary with a symposia and retreat Dr. Anisha Dua and Dr. Vokes is associated with the efficacy of anti-PD-1 Curran and Reem Jan, the Inflammatory Arthritis instability and cancer. Through new grants and featuring illustrious alumni including Drs. Chris- therapy in melanoma patients (Alegre, Clinic has grown and has gained prominence in the renewals, the Section has been able to maintain a topher Walsh (Harvard), Matthew Vander Heiden Gajewski, and colleagues, Science, 2018) community and now includes joint ultrasound. robust grant portfolio enabling them to build impact- (MIT), Mark Krasnow (Stanford) and Mark Anderson Accomplishments, Highlights and Discoveries: ful research programs in multiple areas. The work by (UCSF). The MSTP NIH T32 was also successfully • Demonstrated that IgA antibodies reactive to With research funding of approximately $8.0M, the the research group has been featured in high impact renewed making it one of the longest, continually • Marisa Alegre, MD, PhD – Named as the 2018 • Anisha Dua, MD – Recipient of the 2018 the microbiota are selected for polyreactivity Section’s robust investigative programs focus on journals such as Cell, NEJM, Science, Nature Immunol- NIH-funded programs in the United States. Harvard Paul Russell Visiting Professor Department of Medicine’s Clinical Service Award (Wilson, Bendelac, and colleagues, Science, 2018)

2018 Annual Report 43 NAME PGY LEVEL MEDICAL SCHOOL ATTENDED NAME PGY LEVEL MEDICAL SCHOOL ATTENDED First Year Residents

Eric Swei III Ohio State University Julia Nath I University of Chicago NAME PGY LEVEL MEDICAL SCHOOL ATTENDED Natalie Tapaskar III Case Western Reserve University Patrick Naureckas I University of Illinois Daniela Anderson I University of Utah Adam Vohra III University of Chicago Shirlene Obuobi I University of Chicago Omar JamiL I University of Illinois Thomas Wagner III Medical College of Wisconsin Kevin Prescott I University of Illinois Ira Kraft I University of Utah Corey Rearick I University of Pittsburgh Natalie Munger I University of Washington Second Year Residents Ashely Smith-Nunez I University of Washington Murtaza Bharmal II University of Vermont Ragha Suresh I Rutgers University Dermatology Residents Kent Brummel II Northwestern University Joseph Thomas I Indiana University Third Year Residents Jennifer Cooperrider II Ohio State University Dennis Jingzhou Wang I University of Virginia Bonnie Diep II University of Southern California Joshua Waytz I University of Chicago Stephanie Kazantsev IV University of Chicago Elizabeth Donnelly II University of Chicago Joseph Weber I Loyola University Kathleen Kelley IV Indiana University Residents & Residents Fellows Donald Goens II University of California, San Francisco Kathleen Wiest I University of Chicago Larry Napolitano IV Case Western Reserve University Internal Medicine Residents Gregory Ingolia II University of Colorado Maryam Zafer I Icahn School of Medicine at Mount Sinai Anthony Kanelidis II University of Miami 2018 Chief Residents Second Year Residents Shivani Khanna II Boston University Preliminary NAME PGY LEVEL MEDICAL SCHOOL ATTENDED Neal Klauer II University of Minnesota Clifford Hsieh III University of Chicago Amrish Deshmukh Case Western Reserve University Brian Labadie II University of California, Irvine Kurt Alberson I University of Chicago Emily Lund III Columbia University Abdulrahman Dia University of Illinois Jonathan Lattell II Loyola University Rohan Katipally I Brown University Jared Wishik III University of Florida Michelle Fletcher University of Chicago Betty Li II University of Illinois Katrina Kesterson I University of Tennessee First Year Residents Erica MacKenzie University of Chicago Austin Lin II University of Michigan Saira Khanna I University of Wisconsin Maria Maldonado II Baylor College of Medicine Lukas Matern I University of Chicago Julia Dai II University of Pennsylvania 2019 Chief Residents Michael Maranzano II Duke University Maurenn Riegert I University of Wisconsin Arjun Dayal II University of Chicago Lauren Feld Icahn School of Medicine at Mount Sinai Steven Mazzone II Rush Medical College Ruth Tangonan I University of Illinois Erin Dodd II University of Minnesota Sarah Gray University of Michigan Christopher Miller II University of Illinois Esther Kim II University of Central Florida Marie McKinnon University of Colorado Rebeca Ortiz Worthington II University of Chicago Physician Scientist Development Program David Tehrani University of California, Irvine Charles Oshinsky II New York University Emergency Medicine Residents Raghavendra Paknikar II University of Michigan Ariel Halper-Stromberg II Cornell University Third Year Residents Third Year Residents Eleanor Reimer II University of Michigan Benjamin McDonald II University of Chicago Nina Arhin III Meharry Medical College Hannah Roth II University of Chicago Matthew Odenwald II University of Chicago Zakaria Abdulnabi III Case Western Reserve University Rene Bermea, Jr III University of Chicago Brooke Scheidemantle II Thomas Jefferson University Athalia Pyzer II University of Birmingham Patrick Ardron-Hudson III Oregon Health & Science University Brittany Bindon III Loyola University Anthony Serritella II Johns Hopkins University Obada Shamaa II Ohio State University Maureen Canellas III University of Colorado Keely Browning III Medical College of Wisconsin Wenfei Wang II University of Toledo Joseph Goldenberg I University of Illinois Mark Chottiner III University of Maryland Kirk Cahill III University of Chicago Hannah Wey II Rutgers University Jeremy Treger I University of Chicago Dustin Harris III University of California, Los Angeles Mike Cheng III Case Western Reserve University William Wilson II Indiana University Lauren Young I New York University Michelle Ho III University of Maryland Noura Choudhury III University of Chicago Thomas Yates II Wake Forest University Andrew Hogan III University of Texas, Southwestern Anthony de la Pena III University of Illinois Medicine-Pediatrics Program Eric Keast III University of Michigan First Year Residents Sarah Feenstra III University of Chicago Jason Kopec III University of Rochester Fourth Year Residents Christopher Fernandes III University of Illinois Rasidat Adeduntan I University of Virginia Hani Kuttab III Loyola University Felipe Fernandez del Castillo III University of Massachusetts Gaurav Ajmani I University of Chicago Zainab Abdul-Rahim IV University of Massachusetts Zayir Malik III Emory University Christopher Frohne III University of Virginia Spencer Carpenter-Carter I University of North Carolina Rebecca Chohlas-Wood IV University of Washington Abdullah Pratt III University of Chicago Amulya Gampa III University of Illinois Ellen Daily I University of Chicago Thomas Couri IV University of Chicago Kevin Quirke III Loyola University Raffi Hagopian III Ohio State University Anup Das I University of Michigan Robert Sanchez IV University of Chicago Charlotte Roy III Cornell University Michael Hawking III University of Michigan James Dolezal I University of Pittsburgh Brian Strickland III University of Southern California Jennifer Houpy III University of Chicago Jonathan Dowd I Loyola University Garth Walker III University of Illinois at Chicago Third Year Residents Anupama Joseph III Ohio State University Marie Dreyer I Medical College of Wisconsin Joshua Katz III Loyola University Nolan Faust I University of Chicago Erin Hickey III University of Colorado Second Year Residents Kendall Kling III Loyola University Dariusz Hareza I Albert Einstein College of Medicine of Yeshiva University Stephanie Kelly III McGill University Grace Koo III University of Maryland Jacobi Hines I University of Virginia Jori Sheade III Rush Medical College Leslie Anderson II University of Rochester Shawn Kothari III University of Pennsylvania Michael Jacobs I Thomas Jefferson University Daniel Teixeira da Silva III Boston University Brian Bush II University of Pittsburgh Ernesto Llano III University of Texas, Southwestern So Lim Kim I Case Western Reserve University Adriana Coleska II University of Michigan Alexandru Marginean III Chicago Medical School Aristotle Leonhard I Medical College of Wisconsin Emily DeDonato II Ohio State University Second Year Residents Daniel Meza III University of Illinois Ross McMillan I Johns Hopkins University Annette Dekker II Northwestern University Elizabeth Munroe III University of Chicago Tamari Miller I University of Chicago Alanna Burnett II University of Illinois Amelia Derstine II University of Michigan Justin Porter III New York University Nupur Mistry I Saint Louis University Nathan Georgette II Harvard University Christopher Harris II University of Virginia Elzbieta Stob III Creighton University Amol Naik I University of Chicago Sanjay Jumani II Rutgers University Matthew Heuton II Harvard University Julia Sun III Duke University Bennett Waxse II University of Texas, Southwestern Courtney Hutchins II Rush Medical College

2018 Annual Report 45 NAME PGY LEVEL MEDICAL SCHOOL ATTENDED RESIDENCY

Joseph Venturini VI Loyola University University of Chicago Gastroenterology, Hepatology and Nutrition NAME PGY LEVEL MEDICAL SCHOOL ATTENDED RESIDENCY Rajeev Anchan V University of Nebraska University of Nebraska NAME PGY LEVEL MEDICAL SCHOOL ATTENDED RESIDENCY Carolina Soto Chervin IV Universtiy of Illinois University of Chicago Emeka Anyanwu V Case Western Reserve University University of Chicago Jacob Ollech VIII Semmelweis University Hadassah University (NorthShore) Ilya Karagodin V Northwestern University Medical College Medical Center Meghan Steiner IV University of South Carolina Duke University of Wisconsin Edward Villa VII Loyola University Loyola University Garth Strohbehn IV Yale University of Michigan Isla McClelland V Georgetown University Medstar Adjoa Anyane-Yeboa VII University of Cincinnati University of Illinois Sherin Rouhani III University of Virginia University of Chicago Georgetown University at Chicago Andrew Oehler V Indiana University Oregon Health and Amanda Israel VI University of British Columbia University of Ottawa Hospital Medicine/Hospitalist Scholars Science University Thomas Lu VI University of Cincinnati University of Chicago Pooja Gala V Weill Cornell New York University Dong Bo Yu V University of Texas, Southwestern University of Chicago Bianca Chang VI Cornell University Cedars-Sinai Medical Ali Thaver V Aga Khan University Johns Hopkins Mark Belkin IV Rush Medical College University of Chicago Center University Mark Dela Cruz IV University of California, University of California, Matthew Stier VI Purdue University University of Chicago Michael Cui IV University of Chicago University of Chicago Residents & Residents Fellows San Francisco San Francisco Yunwei Wang VI Shanxi Medical University, China University of Nevada Vivian Lee IV Chicago Medical School Case Western Reserve University Abdulrahman Dia IV University of Illinois University of Chicago Thomas Cotter V NUI Galway School of Medicine, Mayo Clinic Emergency Medicine Residents Michael Henry IV Loyola University University of Michigan Ireland Infectious Diseases & Global Health Swati Rao IV University of Utah Thomas Jefferson Sujaata Dwadasi V Indiana University Emory University Margaret Newman VI University of Illinois at Chicago University of Illinois Second Year Residents (Continued) University Nina Gupta V University of Chicago University of Chicago at Chicago NAME PGY LEVEL MEDICAL SCHOOL ATTENDED Interventional Cardiology Matthew Berger IV St. George's University Stony Brook University Maggie Collison IV Michigan State University Boston University Leigh Jackson II Meharry Medical College Rohan Kalathiya University of Kentucky Johns Hopkins University Hospital Gregory Olson IV University of Illinois at Peoria Beth Israel Deaconess Brendan McEvoy II University of Michigan Noa Cleveland IV University of Illinois University of Chicago Thomas O'Brien II Rutgers University Clinical Cardiac Electrophysiology Ye Eun Kwak IV Seoul National University Yale University/ Nephrology Kristina Pfeiffer II New York University Christopher Jones VII East Carolina University Marshall University College of Medicine Bridgeport Hospital Saurabh Chawla V Medical College of John H. Stroger Jr. Saaduddin Siddiqui II University of Chicago Arun Kannan VII Kilpauk Medical College Canton Medical Charles Muller IV University of Chicago University of Chicago Thiruvananthapuram Hospital Joseph Tarran II University of Chicago Education Foundation Parita Patel IV Case Western Reserve University University of Chicago Victoria Vo V University of Arizona University of Eric Wang II Georgetown University Zenith Jameria VII Indiana University University of Cincinnati Jennifer Wang IV University of Virginia University of Virginia South Carolina William Weber II Northwestern University Sai Prasad Gadapa IV Kakatiya Medical College, India St. Francis Advanced Heart Failure Geriatrics and Palliative Medicine Medical Center Imo Ebong VII University of Nigeria Cleveland Clinic Vania Leung (Geriatrics) IV University of Illinois University of Illinois Samantha Gunning IV Georgetown University University of Chicago First Year Residents Nikhil Narang VII University of Illinois University of Chicago at Chicago Ryyan Hyder IV University of Missouri University of Texas, Dany Accilien I Florida International University Kalie Kebed VII University of Minnesota Mayo Clinic Allison Thoburn (Geriatrics) IV University of Illinois University of Chicago Houston Yom Alemante I University of Southern California Nina Rashedi VII Chicago Medical School Cleveland Clinic Katelyn R. Good (Palliative) V Virginia Commonwealth University University of Chicago Nevin Murthy IV Chicago Medical School University of Louisville Ben Arevalo I Harvard University Gina Piscitello (Palliative) IV University of Minnesota University of Chicago Javeria Syed IV Aga Khan University Dow Medical College Danielle De Freitas I Meharry Medical College Dermatology Saud A. Siddiqui (Palliative) IV Ziauddin Medical College University of Illinois Casey Distaso I Georgetown University Amer Almohssen V King Abdulaziz University Rutgers University Pulmonary/Critical Care Jasmine Ginn I Howard University (Saudia Arabia) Hematology/Oncology Karen Dugan VII Ohio State University University of Chicago Deirdre Goode I University of Virginia Dena Elkeeb V Tripoli University (Libya) University of Utah Arpita Desai VII Kempegowda Institute University of Buffalo Heng Duong VII Case Western Reserve University University of California, Dexter Graves I Drexel University of Medical Science San Francisco Samantha Hay I Virginia Commonwealth University Endocrinology, Diabetes and Metabolism (Adult) Anu Neerukona VII Kamineri Institute State University of William Parker VII University of Chicago University of Chicago Mike Hernandez I Columbia University Laura Dickens VI Emory University University of Chicago New York Juan Rojas VII University of Illinois at Chicago University of Chicago Michael McCartin I University of Chicago Isabel Casimiro V University of Washington University of Chicago Benjamin Derman VI Northwestern University Rush University Sivasubramanium VI University of Texas, Galveston Baylor University Jonathan Oskvarek I University of Chicago Sonaina Imtiaz V Rawalpindi Medical College, North Shore Medical Andrew Hantel VI Loyola University University of Chicago (Siva) Bhavani Daven Patel I University of Illinois at Chicago Pakistan Center, Salem, MA Michael Jelinek VI Rush Medical College University of Chicago James Katsis VI St. George's University Georgetown University Arthur Pope I Loyola University Sikarin Upala V Siriraj Hospital Faculty, Bassett Medical Center Smita Joshi VI University of Chicago University of Chicago Lucas Kimmig VI University of Freiburg University of Pennsylvania Regina Royan I University of Michigan of Medicine Thailand Joseph Wynne VI New York University University of Chicago Julie Lin VI University of Texas, Southwestern University of Texas, Semhar Tesfai I Columbia University Monika Darji IV Chicago Medical School University of Louisville Brian Heiss V University of Maryland University of Pittsburgh Southwestern Thaer Idrees IV University of Damascus Presence Saint Joseph Michael Leukam V Loyola University University of Chicago Xuan (Susan) Han V University of Chicago University of Chicago Fellows: Faculty of Medicine Hospital Marquita Nelson V Emory University Emory University Cathryn Lee V Emory University University of Chicago Cardiovascular Diseases Ofaf Osman V Weill Cornell Johns Hopkins William Dwight Miller V University of Virginia University of California, NAME PGY LEVEL MEDICAL SCHOOL ATTENDED RESIDENCY Endocrinology, Diabetes and Metabolism University Los Angeles Lane Benes VI University of Wisconsin University of Chicago (Pediatrics) Daniel Olson V Rush Medical College Northwestern University Erica MacKenzie V University of Chicago University of Chicago Tharian Cherian VI University of Chicago Stanford University Tara Rajiyah V Royal College of Surgeons, Newark Beth Israel Sheila Padma Rajogopal V Columbia University University of Pittsburgh Steven Pearson IV University of Illinois at Chicago University of Chicago Heddy Luise Holzhauser VI International Program Albert Einstein College Ireland Medical Center, New Jersey Jonathan Trujillo V University of Iowa University of Chicago Danielle Stahlbaum IV Case Western Reserve University University of Chicago of Medicine Harini Kolluri V Andhra Medical College, India John H. Stroger Jr. Hospital Amy Wang V McGovern Medical University of Chicago Matthew Stutz V University of Chicago University of California,

NAME PGY LEVEL MEDICAL SCHOOL ATTENDED RESIDENCY Mary McCauley IV University of Illinois Lutheran General Hospital Anand Patel IV University of Missouri Northwestern University Los Angeles Paul Larsen VI Tulane University University of California Maria Salguero Bermonth IV Universidad de Antioquia Harvard Medical School Natalie Reizine IV Loyola University University of Chicago Andrew Putnam VI Loyola University University of Michigan Facultad de Medicina, Colombia

2018 Annual Report 47 NAME POSITION INSTITUTION NAME POSITION INSTITUTION NAME POSITION INSTITUTION Priya Mehta Cardiology Fellow Northwestern University Jacob Moore Staff Physician Rush University Vanessa Alonso (Geriatrics) Attending Physician Stroger Hospital of Jerry Nnanabu Cardiology Fellow University of Medical Center Cook County Washington Natalie Neumann Toxicology Fellow Rocky Mountain Poison Adeela Cheema (Geriatrics) Research Associate University of Chicago Parita Patel Gastroenterology Fellow University of Chicago & Drug Center, Denver, CO Chandni Patel (Geriatrics) Health System Clinician Northwestern University Caitlyn Plonka Hospitalist St. Joseph Michigan Archana Shah Fellow Mt. Sinai (Vituity), Chicago, IL Steven Pearson Pulmonary/Critical Care Fellow University of Chicago Brian Sprouse Clinical Instructor Rush University Hematology/Oncology Gina Piscitello Palliative Care Fellow University of Chicago Medical Center Christine Bestvina Asssistant Professor University of Chicago Natalie Reizine Hematology/Oncology Fellow University of Chicago Shameeke Taylor Global Health Fellow Mt. Sinai St. Luke’s, Michael Drazer Coggeshall Fellow University of Chicago Trisha Saha Allergy & Immunology Fellow Johns Hopkins University New York, NY James Godfrey Coggeshall Fellow University of Chicago Claire Shappell Pulmonary/Critical Care Fellow Brigham and Women’s Joshua Wunder Staff Physician Advocate Sherman Abiola Ibraheem Advanced Fellow University of Chicago Hosptial Hospital, Elgin, IL Allison West Clinical Cancer Geneticist at the Northshore Residents & Residents Fellows Ethan Silverman Palliative Care Fellow University of Wisconsin Richard Zhang Attending Physician Mercy, St. Joseph & Kellogg Cancer Center Danielle Stahlbaum Pulmonary/Critical Care Fellow University of Chicago CE, Aurora & Joliet, IL Kristen Whitaker Assistant Professor Fox Chase Sleep Medicine Allison Thoburn Geriatrics Fellow University of Chicago Cancer Center NAME PGY LEVEL MEDICAL SCHOOL ATTENDED RESIDENCY Eisha Wali Hospitalist University of Chicago Cardiology Abagail Doyle VII Michigan State Metro Health, WY Hannah Wenger Rural Health Leadership Fellow Massachusetts General Hospital Bhavna Balaney Cardiologist JenCare Senior Infectious Diseases and Global Health Julie Neborak IV University of Minnesota University of Chicago Medical Center Amutha Rajagopal Preventative Medicine Residency University of California,San Diego Syema Sheikh VII Chicago Medical School University of Chicago Medicine-Pediatrics Rohan Kalathiya Advanced Interventional Cardiology Fellow University of Chicago Leona Ebara Staff Physician Nihon Clinic, Arlington Heights, Jessica Gold Genetics Fellows University of Pennsylvania Kalie Kebed Cardiac Imaging Fellow University of Chicago Illinois Interventional Pulmonology Katie Good Palliative Care Fellow University of Chicago Luke Laffin Assistant Professor Cleveland Clinic Udit Chaddha VII Seth GS Medical College (India) University of Louisiana Ellora Karmarkar Epidemiology Intelligence Service Fellow Center for Nikhil Narang Advanced Heart Failure & University of Chicago Nephrology Disease Control Transplant Cardiology Fellow Ziad Al Khouri Attending Physician Private Practice Rheumatology Amy Wang Hematology/Oncology Fellow University of Chicago Jeremy Stone Assistant Professor University of Nebraska Sangeet Dhillon-Jhattu Attending Physician Private Practice Pankti Reid VI Ohio State University University of Cincinnati Medical Center Malgorzata Kochanek Attending Physician Private Practice Iazsmin Ventura VI Universidade de Brasilia Icahn School of Medicine Dermatology Akhil Narang Assistant Professor Northwestern University Fuoad Kutuby Attending Physician Private Practice Veena Patel VI American University of Antigua UTHealth McGovern Laura Buford Private Practice High Plains Dermatology, Neha Goyal Cardiac Imaging Faculty India College of Medicine Medical School Amarillo, TX Jonathan Rosenberg Interventional Cardiologist Faculty Northshore University Pulmonary/Critical Care Josna Haritha VI University of Alabama Virginia Commonwealth Jingyun(Juliana) Gao Private Practice Kaiser Permanente, Health System Nathan Schoettler Coggeshall Fellow University of Chicago University Gaithersburg, MD Taishi Hirai CTO/CHIP Fellow Mid America Heart Institute David Wu Instructor University of Chicago Emily Kitchin IV Indiana University Medical College of Ashley Jenkins Private Practice Central Missouri Ben Chung Clinical Associate University of Chicago Krysta Wolfe Assistant Professor University of Chicago Wisconsin Dermatology, Columbia, MO Ann Nguyen Research Fellow University of Chicago Patrick Onkka IV Indiana University Rush University Rebecca Kaiser Private Practice Dermatology Sleep Medicine Associates, VA Endocrinology, Diabetes & Metabolism Farbod Ghods Attending Physician Kaiser Permanente, Resident and Fellow Program Graduates Lohini Sundharkrishnan Private Practice Derick Dermatology, Mizuho Mimoto MSP Staff Physician University of California, California FY18 Elgin, IL San Diego Amanpreet Kaur Attending Physician Valporaiso, IN Carmela Kiraly Attending Physician Ohio Internal Medicine Emergency Medicine Pediatric Endocrinology, Diabetes & Metabolism NAME POSITION INSTITUTION Sina Akhavan Staff Physician Kaiser Permanente, Michelle Lemelman Assistant Professor University of Chicago Interventional Pulmonology Maria Bacalao Rheumatology Fellow University of Texas, Downey, CA Susan Tucker Pediatric Endocrinologist Wheaton, IL Jonathan Kurman Assistant Professor Medical College of Wisconsin Southwestern Dillon Barron Fellow CEP America & Presence St. Mark Belkin Cardiology Fellow University of Chicago Francis, Chicago, IL Gastroenterology, Hepatology & Nutrition Margaret Boyle Dermatology Resident University of Chicago Lauren Cooper Sports Medicine Fellow Stanford University Roni Weisshof Staff Gastroenterologist Rambam Medical Center Kira Charney Hospitalist Lake Forest Hospital Michael Ernst Attending Physician Emergency Medicine Steven Shamah Advanced Endoscopy Faculty Rabin Medical Center, Michael Cui Medical Informatics Fellow University of Chicago Consultants, Dallas, TX Petah Tikva Andre Davies Hospitalist Northwestern University Steven Flynn Attending Physician Methodist Hospital, Adam Mikolajczyk Assistant Professor University of Illinois at Chicago Abdulrahman Dia Cardiology Fellow University of Chicago Gary, IN Neha Nigam Assistant Professor Northwestern University Amrish Deshmukh Cardiology Fellow University of Michigan Rachel Gilmer Fellow Memorial Medical Anna Lipowska Assistant Professor University of Illinois at Chicago Michelle Fletcher Hospitalist Northwestern University Center ,Modesto, CA Mark Anthony Sofia Assistant Professor Oregon Health & Greg Haman Private Practice Cermak Health Services Mobola Kukoyi Attending Physician Carle Foundation Science University of Cook County Hospital, Urbana, IL George Ou Staff Gastroenterologist St. Paul’s Hospital/ Rebecca Harris Chief Resident MacNeal Hospital Albert Leung Staff Physician Kaiser Permanente, University of British Columbia Blake Jones Gastroenterology Fellow University of Colorado San Francisco, CA Albert Lee Hospitalist Cleveland VAMC Andrew Marshall Clinical Informatics Fellow Beth-Israel Deaconess Geriatrics and Palliative Medicine Linda Lee Chief Resident MacNeal Hospital Medical Center Michael Huber (Palliative) Clinical Assistant Professor University of Illinois Zachary Lonjers Nocturnist MacNeal Hospital at Chicago Erica MacKenzie Pulmonary/Critical Care Fellow University of Chicago Emily Escue (Palliative) Faculty University of Minnesota

2018 Annual Report 49 Select High Impact Publications

Nature Genetics Department of Medicine faculty are very prolific, publishing 7. Mimoto MS; Oyler JL; Davis AM. Evaluation and Treatment of Hirsutism in 1. Day FR; Thompson DJ; Helgason H; Chasman DI; Finucane H; Sulem P; Ruth 2. Torres VE; Chapman AB; Devuyst O; Gansevoort RT; Perrone RD; Premenopausal Women. Journal of the American Medical Association KS; Whalen S; Sarkar AK; Albrecht E; Altmaier E; Amini M;... Im HK; Hinds D; Koch G; Ouyang J; McQuade RD; Blais JD; Czerwiec FS; Sergeyeva O. nearly 1,600 original articles in a number of outstanding 319(15), 2018 Murray A; Murabito JM; Stefansson K; Ong KK; Perry JRB. Genomic analyses Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney internal medicine and subspecialty journals. Below is a 8. Cotts KG; Cifu AS. Treatment of Osteoporosis. Journal of the American identify hundreds of variants associated with age at menarche and support Disease. The New England Journal of Medicine 377(20), 2017 sampling of some recent high impact papers. Medical Association 319(10), 2018 a role for puberty timing in cancer risk. Nature Genetics 49(6), 2017 3. Marty FM, Ljungman P, Chemaly RF, Maertens J, Dadwal SS, Duarte 9. Sargis RM; Davis AM. Evaluation and Treatment of Male Hypogonadism. 2. Phelan CM; Kuchenbaecker KB; Tyrer JP; Kar SP; Lawrenson K; Winham RF, Haider S, Ullmann AJ, Katayama Y, Brown J, Mullane KM, Boeckh Journal of the American Medical Association 319(13), 2018 SJ; Dennis J; Pirie A; Riggan MJ; Chornokur G; Earp MA; Lyra PC Jr; Lee M, Blumberg EA, Einsele H, Snydman DR, Kanda Y, DiNubile MJ, Annals of Internal Medicine 10. Shah SD; Cifu AS. From Guideline to Order Set to Patient Harm. Journal of JM; Coetzee S; Beesley J; McGuffog L;... Olopade OI; … Pharoah PD. Teal VL, Wan H, Murata Y, Kartsonis NA, Leavitt RY, Badshah C. 1. Laiteerapong N; Cooper JM; Skandari MR; Clarke PM; Winn AN; Naylor RN; the American Medical Association 319(12), 2018 Identification of 12 new susceptibility loci for different histotypes Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell of epithelial ovarian cancer. Nature Genetics 49(5), 2017 Huang ES. Individualized Glycemic Control for U.S. Adults With Type 2 11. Cifu AS. Improving Diagnostic Decisions-Reply. Journal of the American Transplantation. The New England Journal of Medicine 377(25), 2017 Diabetes: A Cost-Effectiveness Analysis. Annals of Internal Medicine Medical Association 319(2), 2018 3. Wu L; Shi W; Long J; Guo X; Michailidou K; Beesley J; Bolla MK; Shu 4. Mehra MR, Goldstein DJ, Uriel N, Cleveland JC Jr, Yuzefpolskaya M, 168(3), 2017 XO; ...; Olopade OI; .. Zheng W. A transcriptome-wide association 12. Sargis RM, Davis AM. Evaluation and Treatment of Male Hypogonadism. Salerno C, Walsh MN, Milano CA, Patel CB, Ewald GA, Itoh A, Dean D, study of 229;000 women identifies new candidate susceptibility 2. Farnan JM; Arora VM. Annals for Hospitalists Inpatient Notes -Gender Journal of the American Medical Association; 319(13), 2018 Krishnamoorthy A, Cotts WG, Tatooles AJ, Jorde UP, Bruckner BA, Estep Equality in Hospital Medicine - Are We There Yet? Annals of genes for breast cancer. Nature Genetics 50(7), 2018 JD, Jeevanandam V, Sayer G, Horstmanshof D, Long JW, Gulati S, Skipper Internal Medicine 167(6), 2017 4. Gamazon ER; Segre AV; van de Bunt M; Wen X; Xi HS; Hormozdiari F; ER, O’Connell JB, Heatley G, Sood P, Naka Y; MOMENTUM 3 Investigators. 3. Graham KL; Auerbach AD; Schnipper JL; Flanders SA; Kim CS; Robinson EJ; Journal of Clinical Investigation Ongen H; Konkashbaev A; Derks EM; Aguet F; Quan J; Nicolae DL; Eskin Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Ruhnke GW; Thomas LR; Kripalani S; Vasilevskis EE; Fletcher GS; 1. Kang HS; Kumar D; Liao G; Lichti-Kaiser K; Gerrish K; Liao XH; Refetoff S; E; Kellis M; Getz G; McCarthy MI; Dermitzakis ET; Cox NJ; Ardlie KG. Using Heart Failure. The New England Journal of Medicine 378(15), 2018 Sehgal NJ; Lindenauer PK; Williams MV; Metlay JP; Davis RB; Yang J; Jothi R; Jetten AM. GLIS3 is indispensable for TSH/TSHR-dependent thyroid an atlas of gene regulation across 44 human tissues to inform complex 5. White WB; Saag KG; Becker MA; Borer JS; Gorelick PB; Whelton Marcantonio ER; Herzig SJ. Preventability of Early Versus Late Hospital hormone biosynthesis and follicular cell proliferation. Journal of Clinical disease- and trait-associated variation. Nature Genetics 50(7), 2018 A; Hunt B; Castillo M; Gunawardhana L. Cardiovascular Investigation 127(12), 2017 Readmissions in a National Cohort of General Medicine Patients. 5. Demenais F; Margaritte-Jeannin P; Barnes KC; Cookson WOC; Altmuller Safety of Febuxostat or Allopurinol in Patients with Gout. Annals of Internal Medicine 168(11), 2018 J; Ang W; Barr RG; Beaty TH; Becker AB; ..., Nicolae DL. Multiancestry The New England Journal of Medicine 378(13), 2018 association study identifies new asthma risk loci that colocalize 6. Bakris G; Sorrentino M. Redefining Hypertension - Assessing the New Blood- Lancet with immune-cell enhancer marks. Nature Genetics 50(1), 2018 Pressure Guidelines. The New England Journal of Medicine 378(6), 2018 Cell 1. Winston DJ; Mullane KM; Cornely OA; Boeckh MJ; Brown JW; Pergam SA; 6. Li YI; Knowles DA; Humphrey J; Barbeira AN; Dickinson SP; 7. Mateos MV; Dimopoulos MA; Cavo M; Suzuki K; Jakubowiak A; Knop S; 1. Chen YQ; Wohlbold TJ; Zheng NY; Huang M; Huang Y; Neu KE; Lee J; Wan H; Trociukas I; Zak P; Craig MD; Papanicolaou GA; Velez JD; Panse J; Hurtado K; Im HK; Pritchard JK. Annotation-free quantification of RNA Doyen C; Lucio P; Nagy Z; Kaplan P; Pour L; Cook M; Grosicki S; Crepaldi A; Rojas KT; Kirkpatrick E; Henry C; Palm AE; Stamper CT; Lan LY; Topham DJ; Fernsler DA; Stek JE; Pang L; Su SC; Zhao Y; Chan ISF; Kaplan SS; Parrino J; splicing using LeafCutter. Nature Genetics 50(1), 2018 Liberati AM; Campbell P; Shelekhova T; Yoon SS; Iosava G; Fujisaki T; Garg Treanor J; Wrammert J; Ahmed R; Eichelberger MC; Georgiou G; Krammer F; Lee I; Popmihajlov Z; Annunziato PW; Arvin A. Inactivated varicella zoster M; Chiu C; Wang J; Carson R; Crist W; Deraedt W; Nguyen H; Qi M; San- Wilson PC. Influenza Infection in Humans Induces Broadly Cross-Reactive vaccine in autologous haemopoietic stem-cell transplant recipients: Miguel J. Daratumumab plus Bortezomib; Melphalan; and Prednisone for and Protective Neuraminidase-Reactive Antibodies. Cell 173(2), 2018 an international; multicentre; randomised; double-blind; placebo-controlled Nature Medicine Untreated Myeloma. The New England Journal of Medicine 378(6), 2018 trial. Lancet 391(10135), 2018 1. McDermott DF; Huseni MA; Atkins MB; Motzer RJ; Rini BI; Escudier B; 8. Francis PA; Pagani O; Fleming GF; Walley BA; Colleoni M; Lang I; Gomez 2. Charlton M. FGF-19 agonism for NASH: a short study of a long disease. Fong L; Joseph RW; Pal SK; Reeves JA; Sznol M; Hainsworth J; Rathmell Journal of the American Medical Association HL; Tondini C; Ciruelos E; Burstein HJ; Bonnefoi HR; Bellet M; Martino 1. McDermott MM; Spring B; Berger JS; Treat-Jacobson D; Conte MS; Creager Lancet 391(10126), 2018 WK; Stadler WM; …; Powles T. Clinical activity and molecular correlates S; Geyer CE Jr; Goetz MP; Stearns V; Pinotti G; Puglisi F; Spazzapan S; MA; Criqui MH; Ferrucci L; Gornik HL; Guralnik JM; Hahn EA; Henke P; of response to atezolizumab alone or in combination with bevacizumab Climent MA; Pavesi L; Ruhstaller T; Davidson NE; Coleman R; Debled Kibbe MR; Kohlman-Trighoff D; Li L; Lloyd-Jones D; McCarthy W; Polonsky versus sunitinib in renal cell carcinoma. Nature Medicine 24(6), 2018 M; Buchholz S; Ingle JN; Winer EP; Maibach R; Rabaglio-Poretti M; TS; Skelly C; Tian L; Zhao L; Zhang D; Rejeski WJ .Effect of a Home-Based Nature 2. Wong GS; Zhou J; Liu JB; Wu Z; Xu X; Li T; Xu D; …; Catenacci D; Bass AJ. Ruepp B; Di Leo A; Coates AS; Gelber RD; Goldhirsch A; Regan MM. Exercise Intervention of Wearable Technology and Telephone Coaching on 1. Ward MC; Gilad Y. Human genomics: Cracking the regulatory code. Targeting wild-type KRAS-amplified gastroesophageal cancer through Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Walking Performance in Peripheral Artery Disease: The HONOR Randomized Nature 550(7675), 2017 combined MEK and SHP2 inhibition. Nature Medicine 24(7), 2018 Cancer. The New England Journal of Medicine 379 (2), 2018 Clinical Trial. Journal of the American Medical Association 319(16), 2018 2. Michailidou K; Lindstram S; Dennis J; Beesley J; Hui S; Kar S; Lemason A; 2. Anderson I; Cifu AS. Management of Bleeding in Patients Taking Oral Soucy P; Glubb D, … Olopade OI; ….Chanock SJ; Dunning AM; Edwards SL; Anticoagulants. Journal of the American Medical Association 319(19), 2018 Bader GD; Chenevix-Trench G; Simard J; Kraft P; Easton DF. Association New England Journal of Medicine Science 3. Waytz J; Cifu AS; Stern. SDC. Evaluation and Management of Patients with analysis identifies 65 new breast cancer risk loci. Nature 551(7678), 2017 1. Stone RM; Mandrekar SJ; Sanford BL; Laumann K; Geyer S; Bloomfield 1. Bunker JJ; Erickson SA; Flynn TM; Henry C; Koval JC; Meisel M; Jabri Syncope. Journal of the American Medical Association 319(21), 2018 3. Meisel M; Hinterleitner R; Pacis A; Chen L; Earley ZM; Mayassi T; Pierre JF; CD; Thiede C; Prior TW; Dohner K; Marcucci G; Lo-Coco F; Klisovic B; Antonopoulos DA; Wilson PC; Bendelac A. Natural polyreactive IgA RB; Wei A; Sierra J; Sanz MA; Brandwein JM; de Witte T; Niederwieser antibodies coat the intestinal microbiota. Science 358(6361), 2017 4. Tung EL; Davis AM; Laiteerapong N. Glycemic Control in Nonpregnant Ernest JD; Galipeau HJ; Thuille N; Bouziat R; Buscarlet M; Ringus DL; Wang D; Appelbaum FR; Medeiros BC; Tallman MS; Krauter J; Schlenk RF; Adults with Type 2 Diabetes. Journal of the American Medical Association Y; Li Y; Dinh V; Kim SM; McDonald BD; Zurenski MA; Musch MW; Furtado 2. Matson V; Fessler J; Bao R; Chongsuwat T; Zha Y; Alegre ML; Luke JJ; Ganser A; Serve H; Ehninger G; Amadori S; Larson RA; Dohner H. 319(23), 2018 GC; Lira SA; Baier G; Chang EB; Eren AM; Weber CR; Busque L; Godley Gajewski TF. The commensal microbiome is associated with anti-PD-1 LA; Verdu EF; Barreiro LB; Jabri B. Microbial signals drive pre-leukaemic Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a efficacy in metastatic melanoma patients. Science 359(6371), 2018 5. Feld L; Cifu AS. Management of Dyspepsia. Journal of the American Medical myeloproliferation in a Tet2-deficient host. Nature 557(7706), 2018 FLT3 Mutation. The New England Journal of Medicine 377(5), 2017 Association 319(17), 2018 6. Volerman A; Cifu AS. Peanut Allergy Prevention. Journal of the American Medical Association 319 (9), 2018

2018 Annual Report 51 COMMITTEE Highlights

L E G A C Y

The Department of Medicine honors the memory of three extraordinary faculty who served as outstanding scientists, dedicated clinicians and inspirational mentors.

Women’s Committee The Department of Medicine’s Women’s Committee serves as an important mechanism event. The forum was moderated by Dr. Saunders, with participation by Monica Peek, MD and Audrey for networking, mentorship, professional development and advocacy for our female faculty. Tanksley, MD from the Department. Department With leadership from Julie Oyler, MD, the Committee is comprised of women from multiple faculty also helped to lead the second annual sections within the Department, all of whom are amazing leaders, scientists, clinicians and “Black and Latino Men in Medicine” forum, and the educators in their own right. The Committee has added a fourth sub-committee to track the second annual LGBTQI People in Medicine con- number of awards given to women and to nominate women for internal and external awards. ference. The Department also had a commanding presence at the Annual Medical Education Confer- The Women’s Committee Diversity Committee ence of the Student National Medical Association enjoyed several successes in FY18: The Department of Medicine actively promotes diver- in San Francisco and the national Latino Medical sity, community-based research, and understanding Student Association conference held in Miami. • Published two issues of the “Women at the (toward eliminating) health care disparities. Led by OTHER HIGHLIGHTS Forefront” newsletter, highlighting the accom- Monica Vela, MD, and Co-Chair, Milda Saunders, MD, plishments of women faculty and trainees the goal of the Diversity Committee is to build upon FROM FY18 INCLUDE: the long tradition of excellence in the fields of clinical • Hosted Selwyn Rogers, MD, Professor of Surgery LOUIS COHEN, MD ANGELO SCANU, MD KIRK SPENCER, MD • Conducted a workshop on “Managing Work- care, research and education by working to improve & Chief for Trauma and Acute Care Surgery, Professor of Medicine (Cardiology) Professor of Medicine (Cardiology) Professor of Medicine (Cardiology) place Conflict,” featuring Jan Brett, Professor diversity among all programs in the Department. In as the Diversity Committee’s Grand Rounds (1928 – 2018) (1924 – 2018) (1962 – 2018) of Dispute Resolution at Northwestern Uni- FY18, the Department recruited a diverse housestaff speaker, who spoke on “The Role of the versity’s Kellogg School of Management to its residency programs with the intern class of the Trauma Center at the University of Chicago” internal medicine residency (17%) and the emergency • Conducted a workshop, “Dynamics of the Gender medicine residency (33%) programs comprised of • Milda Saunders, MD - Appointed Co-Chair of Gap for Young Professionals in the Financial and underrepresented minorities. The Committee has also the Chicago Outreach of Minority Living Donors Corporate Sectors,” featuring Marianne Bertrand, shepherded the Housestaff Diversity Committee in its Committee. Dr. Saunders was also awarded the the Chris P. Dialynas Distinguished Service Profes- strides to engage in community service events as well Midwest SGIM Advocacy and Community Service sor of Economics at the Booth School of Business as engaging in recruitment and activities to promote Leadership Award and the Department’s 2018 an inclusive climate among residents of color. Diversity Award • Hosted Tejal Gandhi, MD, MPH, CPPS, President and Chief Executive Officer, NPSF Lucian Leape The Diversity Committee serves to focus and pro- • Monica Vela, MD - Appointed to the Advisory Institute, and the Certification Board for Pro- mote activities that improve recruitment, retention, Committee of the National Latino Medical Students fessionals in Patient Safety, Clinical and Safety scholarship, leadership, and mentorship of qual- Association and the Advisory Committee Officer, Institute for Healthcare Improvement, as ified minority students, housestaff and faculty in of the Chicago Medical Organization Please visit medicine.uchicago.edu for a full version of the Women’s Committee’s Grand Round Speak- an environment rich with cultural awareness, and for Latino Involvement the 2018 Department of Medicine Annual Report which includes a full list of sponsored research er for 2018, who spoke on “Free from Harm” sensitivity. In FY18, under the direction of Dr. Vela, the Bowman Society hosted the Second Annual Black • Deborah Burnet, MD and Shellie Williams, MD - Editorial directorship by Annette Westerberg and Latina Women in Medicine Forum: Claiming our Recipients of the Biological Sciences Division’s Art Direction and Graphic Design by Sean Hernandez at Graphic Arts ([email protected]) Space. Over 60 medical students and residents from Distinguished Leader in Community Photography by Jean Lachet and photographers at UC Creative and UCM Marketing all of the medical schools in Chicago attended the Service and Advocacy Awards Special thanks to Marguerite Boone, Shanda Lentz and Samantha Delacruz for editorial assistance

2018 Annual Report 53 Total Total Sponsored Awards Research

Section of Cardiology Section of Computational Biomedicine and Biomedical Data Science PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE PUBLIC HEALTH SERVICE Alenghat, Francis Integrin-Triggered Signaling and Macrophage Mode $136,085 $10,887 Grossman, Robert The Bionimbus Protected Data Cloud - Supplement 1 $78,097 $45,296 Switching in Atherosclerosis Innovation through Collaboration at the .Iintersection of Childhood $565,613 $350,680 Broman, Michael FOG-2 Upregulation Induces Atrial Fibrillation $132,037 $10,563 Development and Cancer: A Platform for the Gabriella Miller Liao, James Cardiovascular Sciences Training Grant $483,606 $36,255 Kids First Pediatric Data Resource Center Mechanisms Underlying Vascular Aging $250,000 $155,000 NASA GEO: EF5 $18,714 $11,602 Ozcan, Cevher Mitochondrial Mechanisms and Novel Therapeutic $151,800 $12,144 NIAID Data Hub Pilot $643,959 $399,255 Targets in Atrial Fibrillation NIH Data Commons Pilot Phase $342,214 $212,173 Polonsky, Tamar Myocardial Ischemia & Transfusion (MINT) $44,937 $27,861 Developing and Low InTensity Exercise intervention in PAD: The LITE Trial $2,168 $1,344 Operating a Data Commons Framework Services $1,420,086 $880,453 Improve PAD PERformance with METformin: The PERMET Trial $2,801 $1,737 NHLBI Commons Pilot $1,153,704 $715,296 Telmisartan Plus Exercie to Improve $3,252 $2,016 Rzhetsky, Andrey Training in Emerging Multidisciplinary Approaches to $263,282 $18,503 Functioning in PAD: The TELEX Trial Mental Health and Disease Total PHS Research $1,206,686 $257,807 2/2-Measuring Translational Dynamics and the Proteome to Identify $289,000 $171,180 Potential Brain Biomarkers for Psychiatric Disease STATE/ASSOCIATION/FOUNDATION GRANTS Total PHS Research $4,774,669 $2,804,438 Blair, John Microvascular Dysfunction in Heart Failure with $70,000 $7,000 Preserved Ejection Fraction (American Heart Association) STATE/ASSOCIATION/FOUNDATION GRANTS Sladojevic, Nikola RGS5 as a Novel Therapeutic Target for Ischemic Stroke $62,560 $0 Grossman, Robert Cohen Veterans Bioscience Data Commons Grant Agreement (CVB) $778,822 $116,823 (American Heart Association) Total State/Association/Foundation Grants $778,822 $116,823 Tabit, Corey Molecular Mechanisms of Non-Surgical Bleeding in $70,000 $7,000 INDUSTRY GRANTS Human Patients with Continuous-Flow Left Ventricular Assist Devices Grossman, Robert Abbvie Partnership (AbbVIe) $89,286 $35,714 (American Heart Association) Total Industry Grants $89,286 $35,714 Total State/Association/Foundation Grants $202,560 $14,000

INDUSTRY GRANTS Total Sponsored Research FY17 FY18 Blair, John Edward A. Specific Research Plan for Clinical intelligence-enabled AKI $41,465 $16,586 Public Health Service $2,017,868 $7,579,107 prevention in PCI patients Project (Philips) State/Association/Foundations $926,586 $895,645 Kawaji, Keigo Next-Generation MRI Systems for Generalized Error-Proof $39,286 $15,714 Industry Grants $125,000 $125,000 MRI Application Co-Development with Philips Clinical Sciences (Philips) TOTAL $3,069,454 $8,599,752

Paul, Jonathan D. Targeted Temperature Management in Cardiogenic Shock (ZOLL) $27,584 $5,517 Spencer, Kirk Thomas Finding-based clinical context delivery (Philips) $14,286 $5,714 Section of Dermatology Tung, Roderick Clinical Cardiac Electrophysiology Fellowship Program (Medtronic) $30,000 $0 PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED Clinical Cardiac Electrophysiology Fellowship Program (Biotronik) $10,000 $0 PUBLIC HEALTH SERVICE He, Yu-Ying Autophagy and GG-NER in UVB-induced skin cancer $225,000 $130,500 Clinical Cardiac Electrophysiology Fellowship Program $40,909 $4,091 Oxidative Stress, Cr(VI) Carcinogenesis, and Prevention $50,000 $29,000 (St. Jude Medical Research) Total PHS Research $275,000 $159,500 University of Chicago Clinical Cardiac Electrophysiology (CCEP) $15,000 $0 Fellowship Program (Boston Scientific) STATE/ASSOCIATION/FOUNDATION GRANTS Advanced Heart Failure and Transplant Cardiology Fellowship Progam $36,364 $3,636 Bolotin, Diana The Impact of Drug Compounding Regulations on $6,350 $0 (St. Jude Medical Research) Dermatologic Practice (American Society of Dermatologic Surgery) Total Clinical Trials Earnings $1,086,287 $271,572 Total State/Association/Foundation Grants $6,350 $- Total Industry Grants $1,341,181 $322,830 INDUSTRY GRANTS Total Clinical Trials Earnings $23,995 $5,999 Total Sponsored Research FY 14 FY 15 FY16 FY17 FY18 Total Industry Grants $23,995 $5,999 Public Health Service $3,816,494 $1,963,339 $1,807,597 $1,478,091 $1,464,493 State/Association/Foundations $429,876 $472,312 $391,786 $452,209 $216,560 Total Sponsored Research FY 14 FY15 FY16 FY17 FY18 Industry Grants $885,107 $1,356,465 $1,668,923 $2,000,440 $1,664,011 Public Health Service $371,039 $361,949 $711,830 $790,830 $434,500 TOTAL $5,131,477 $3,792,116 $3,868,306 $3,930,740 $3,345,064 State/Association/Foundations $310,850 $305,000 $190,000 $84,000 $6,350 Industry Grants - $29,994 TOTAL $681,889 $666,949 $901,830 $874,830 $470,844

2018 Annual Report 57 Total Total Sponsored Awards Research

Section of Emergency Medicine Section of Endocrinology, Diabetes & Metabolism PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE PUBLIC HEALTH SERVICE Beiser, David Mechanical circulatory support: $23,178 $13,443 Bell, Graeme Diabetes Research and Training Center $947,583 $531,706 Measures of adjustment and quality of life (MCS A-QOL) Integrated Clinical and Basic Endocrinology Research $226,522 $18,122 Strategies to Innovate EmeRgENcy Care Clinical Trials (SIREN), $4,363 $2,611 Brady, Matthew J. Circadian Genes and Adipose Function: Impact of Chronotype, $293,400 $144,403 Mid-America CTSA Consortium (MACC) Obesity and Race STEP-UP Program $1,500 $0 Garcia, Alfredo J Neurocognitive Consequences of Intermittent Hypoxia $218,750 $112,840 Dumitrescu, Alexandra M. Mouse Sbp2 deficiency models the multi-system syndrome of $225,000 $125,489 Padela, Aasim Informing American Muslims about Living Donation [I AM a LD] $137,681 $85,362 human SBP2 defects Selenoproteins in Arsenic-Induced $13,008 $8,065 Prabhakar, Nanduri R. Integrative Consequences of Hypoxia $1,440,360 $607,332 Metabolic Dysfunction Therapeutic Targeting of Carotid Body $1,548,556 $167,955 Ehrmann, David A. Diabetes Prevention Program Outcomes Study - Phase 2 $262,229 $146,601 Chemoreflex for Sleep Disordered Breathing ß-cell Function and Cognition in the Restoring $33,290 $19,308 Sharp, Willard W. Pharmacological Induced Torpor/hypothermia as a Novel Therapy $250,000 $145,000 Insulin Secretion (RISE) Study for .Iimproving Post C.cardiac Arrest Resuscitation Outcomes Naylor, Rochelle Advancing Recognition and Personalized Genetic Medicine $173,200 $13,776 Total PHS Research $3,622,888 $1,134,543 for MODY in a Multi-Ethnic US Population Advancing Recognition and Personalized Genetic Medicine for $174,589 $13,807 STATE/ASSOCIATION/FOUNDATION GRANTS MODY in a Multi-Ethnic US Population Hogan, Teresita M. Developing a National Collaborative to Improve Emergency $21,600 $2,160 Philipson, Louis Pediatric Endocrinology Research Training - Renewal 01 $125,835 $10,065 Department Care of Older Adults (Hartford Foundation) Control Systems for Artificial ancreaseP Use During and After Exercise $89,775 $33,934 Padela, Aasim Developing a Tailored Mammography Intervention for $134,954 $10,796 Fault-Tolerant Control Systems for Artificial Pancreas $70,835 $30,184 American Muslims (American Cancer Society) Monogenic Diabetes: Next Generation Diagnosis, $332,279 $192,722 Domesticating Genomics in the Gulf Region (DGGR): $20,007 $4,002 Treatment and Complications The Missing Islamic Bioethical Discourse (Qatar National) Chicagoland Diabetes TrialNet Clinical Center $256,472 $118,396 Engaging Muslim Activists for Research on $78,045 $31,218 Refetoff, Samuel Thyroid Physiology Studies of Inherited Disorders $407,004 $225,957 Community Health (E-MARCH) (PCORI) Rhodes, Christopher J. Central Control of Pancreatic Islet Function $302,523 $160,259 Conversations on Islam and the Human Sciences $77,229 $6,401 Van Cauter, Eve Alterations of Sleep and Circadian Timing in Aging $315,579 $183,036 (Templeton Foundation) Alterations of Sleep and Circadian Timing in Aging $447,701 $259,666 Total State/Association/Foundation Grants $331,835 $54,577 Total PHS Research $4,698,324 $2,235,496

Total Sponsored Research FY 14 FY 15 FY 16 FY17 FY18 STATE/ASSOCIATION/FOUNDATION GRANTS Public Health Service $2,191,789 $3,797,030 $3,696,644 $4,568,855 $4,757,431 Greeley, Siri Atma W. The Impact of Diabetes in Infancy: Clinical, Qualitative, $125,455 $12,545 State/Association/Foundations $285,934 $234,682 $261,822 $253,270 $386,412 and Neurodevelopmental Outcome (American Diabetes Association) Industry Grants $182,173 $142,173 - - Philipson, Louis Mechanisms and Potentiators of Arsenic-induced $10,465 $1,047 TOTAL $2,659,896 $4,173,885 $3,958,466 $4,822,125 $5,143,843 Metabolic Dysfunction (American Diabetes Association) Philipson, Louis Analysis of the Whole Exome in Subjects with $150,000 $15,000 Extreme Forms of Type 1 Diabetes (Helmsley Trust) Total State/Association/Foundation Grants $285,920 $28,592

INDUSTRY GRANTS Bakris, George Hypertension Fellowship Program - (RELYPSA) $70,000 $- Total Clinical Trial Earnings $505,266 $126,317 Total Industry Grants $575,266 $126,317

Total Sponsored Research FY14 FY15 FY16 FY17 FY18 Public Health Service $7,031,818 $6,241,384 $6,431,372 $4,732,504 $6,933,820 State/Association/Foundations $282,750 $366,566 $146,499 $148,000 $314,512 Industry Grants $994,932 $1,022,397 $1,222,825 $553,960 $701,583 TOTAL $8,309,500 $7,630,347 $7,800,696 $5,434,464 $7,949,915

2018 Annual Report 59 Total Total Sponsored Awards Research

Section of Gastroenterology, Hepatology & Nutrition PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE INDUSTRY GRANTS Bissonnette, Bruce Development of 5hmC and 5mC Biomarkers in Cell-free Circulating $409,754 $203,482 Chang, Eugene B. The University of Chicago Medicine Chicago $368,697 $147,479 Extreme Forms of Type 1 Diabetes (Helmsley Trust) PROMIse Proposal to Takeda (Takeda) Chang, Eugene B. Research Training in Digestive Health, Diseases, and Nutrition $383,435 $27,706 Li, Yanchun 2017 ASPIRE US Rheuma IBD _ Does the Renin-Angiotensin $107,143 $42,857 IBD and Mucosal Inflammation, Immunology, $730,723 $423,819 System Promote Colonic Inflammation through the and Microbiology of the GI Tract JAK-STAT Pathways? (Pfizer) Diet Induced Obesity from Gut $522,600 $204,126 Rubin, David T. Center of Excellence for PRecisiOn Medicine in $286,030 $114,413 Microbial Disruption of Host Metabolic Networks IBD Chicago PROMIse (Takeda) Exploring Paneth Cell Peptide YY (PYY), $472,171 $184,766 Advanced IBD Fellowship 2017-2018 (JAN BIO) $83,155 $8,316 a unique anti-microbial peptide that maintains fungal commensalism, IBD SuperFriends: A Peer to Peer Mentoring $57,545 $5,755 in the pathogenesis of ileal Crohn’s Disease Program for IBD Patients. (Takeda) Eren, A Murat Microbial Community Profiles Identify New Indicators $25,262 $14,652 IBD SuperFriends (Pfizer) $9,091 $909 of Waterborne Pathogens Advanced IBD Fellows Research Meeting - $30,000 $0 Harris, Katharine Inter-kingdom communication between $61,174 $0 Gold Level (JAN BIO) Intestinal Microbiota and Mammalian Host via Cyclic Dinucleotides 2018-2019 Inflammatory Bowel Disease $45,455 $4,545 Jabri, Bana Innate and adaptive immunity in celiac disease $336,380 $195,100 Patient Education Events (Abbvie) Pharmacological Validation of Transglutaminase 2 $121,564 $64,939 Community GI Updates in IBD Fellowship Program (Pfizer) $60,564 $6,056 as a Novel Target for Celiac Disease - Resubmission 01 Total Clinical Trial Earnings $581,896 $145,474 Kim, Karen Cook County Colon Cancer Alliance to Reignite and $670,128 $163,392 Total Industry Grants $1,629,576 $475,804 Enhance Screening (Cook County CARES) Center for Health Equity Research (CHER) $11,519 $7,142 Total Sponsored Research FY14 FY15 FY16 FY17 FY18 Kupfer, Sonia S. Host-Environment Interactions in Colorectal Cancer Disparities $108,750 $67,425 Public Health Service $5,846,837 $5,857,444 $6,373,843 $6,121,930 $5,976,824 Leone, Vanessa Diurnal Oscillations in Gut Microbes and Host Immunity $116,423 $8,794 State/Association/Foundations $2,451,084 $2,318,729 $1,775,491 $244,198 $501,240 in Health and Obesity Industry Grants $2,485,488 $2,721,045 $913,065 $2,510,196 $2,105,380 Li, Yanchun Macrophage m6A mRNA Methylation in Sepsis $125,000 $77,500 TOTAL $10,783,409 $10,897,218 $9,062,399 $8,876,324 $8,583,444 Messer, Jeannette S The Role of HMGB1 in Gut Antimicrobial Defense and the $113,440 $9,075 Pathophysiology of Inflammatory Bowel Disease Pekow, Joel R. New model to dissect molecular pathways in $50,000 $31,000 IBD-neoplasia using human colonoids Fecal Microbiome Transplant National Registry $714 $286 Pillai, Anjana A Extracellular non-coding RNA biomarkers of hepatocellular cancer $18,518 $11,482 Rubin, David T. Fecal Microbiome Transplant National Registry $2,829 $1,754 Total PHS Research $4,280,384 $1,696,440

STATE/ASSOCIATION/FOUNDATION GRANTS Chang, Eugene B. Aberrant Tissue .Rresponses and .Mmicrobial $303,531 $30,352 Triggers that Promote the Development of UC Pouchitis: Gathering Clues to Understand Human Inflammatory Bowel Diseases (Helmsley Trust) Meisel, Marlies Impact of Interleukin 15 on immune homeostasis and the $58,250 $0 intestinal microbiota in the development of inflammatory bowel disease (Crohn’s and Colitis Foundation) Messer, Jeannette S The Role of HMGB1 in the Microbial Pathogenesis of $30,000 $0 Inflammatory Bowel Disease (American Gastroenterological Association) Sakuraba, Atsushi Collaborative Study to Evaluate the Role of Neutrophil FC¿ $65,922 $13,185 Receptor I (CD64) Index as a New Biomarker for Mucosal Healing (MH) and Histologic Remission (HR) in Inflammatory Bowel Disease (IBD) Patients (SPARC/Indiana University) Total State/Association/Foundation Grants $457,703 $43,537

2018 Annual Report 61 Section of General Internal Medicine (Continued) PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED INDUSTRY GRANTS Peek, Monica Bridging the Gap National Program Office (Merck Foundation) $590,235 $88,535 Press, Valerie G. Development of Novel Hospital-initiated $28,705 $11,482 Care Bundle in Adults Hospitalized for Asthma Exacerbation: The 41th Multicenter Airway Research Collaboration (MARC-41) Total Total Sponsored Awards Research Study (NOVAR PH/MASS GEN) Total Industry Grants $618,940 $100,017

Section of General Internal Medicine Total Sponsored Research FY14 FY15 FY16 FY17 FY18 PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED Public Health Service $3,635,696 $3,245,309 $3,189,214 $1,940,689 $2,607,296 PUBLIC HEALTH SERVICE State/Association/Foundations $2,723,046 $1,934,873 $1,374,443 $1,207,697 $724,206 Arora, Vineet SIESTA (Sleep for Inpatients: Educating Staff to Act) $221,614 $17,729 Industry Grants $- $81,997 $840,992 $718,957 IMPROVE $158,228 $91,772 TOTAL $6,358,742 $5,180,182 $4,645,654 $3,989,378 $4,050,459 Mentoring Patient-Oriented Research: $107,070 $8,566 Sleep & Health During & After Hospital Stay Section of Genetic Medicine Mentoring Patient-Oriented Research: $108,570 $8,686 PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE Sleep & Health During & After Hospital Stay Basu, Anindita High Dimensional Single Cell Transcriptomic and $92,100 $5,360 Baig, Arshiya A. Implementing Diabetes Group Visits in Midwestern Community $202,034 $125,261 Proteomic Analysis and Comparison at High Throughput Health Centers to Improve Diabetes Outcomes Chen, Mengjie Collaborative Research: Advanced statistical $245,902 $68,848 among Disadvantaged Patients methods for single cell RNA sequencing studies Burnet, Deborah LUCENT: Leadership for Urban Primary Care $398,344 $31,656 Collaborative Research: Advanced statistical $255,502 $58,804 Education and Transformation methods for single cell RNA sequencing studies Chin, Marshall H. Chicago Center for Diabetes Translation Research $248,345 $144,040 Gilad, Yoav eQTL mapping in iPSC-derived differentiated cardiomyocytes $463,301 $287,247 Huang, Elbert Research and Mentorship in Medical Decision Making in Diabetes $163,754 $13,100 Methods for analysis of regulatory variation in cellular differentiation $134,991 $83,695 Cohort Differences in Social Life and Health: Refreshing the $107,706 $62,469 A National iPS Cell Network with Deep $50,000 $29,000 NSHAP sample Phenotyping for Translational Research Preferences, Management and Outcomes of the $33,168 $20,564 Using single cell RNA-seq to study regulatory noise and robustness $316,209 $196,050 Oldest Patients with Diabetes Using single cell RNA-seq to study regulatory noise and robustness $313,009 $194,066 Miller, Doriane C. Improving the Screening and Management of $239,871 $94,749 Characterizing and mapping gene $430,940 $267,183 Patients with Serious Mental Illness in Primary Care Settings regulatory robustness in cardiomyoctes Total PHS Research $1,988,704 $618,592 Im, Hae Kyung Predicted Gene Expression: High Power, $272,518 $158,060 Mechanism, and Direction of Effect STATE/ASSOCIATION/FOUNDATION GRANTS Genomic and Transcriptomic $15,589 $9,042 Arora, Vineet VISTA (Value, Improvement, Safety, and Team Advocates): $25,000 $0 Analysis of Emphysema and Subclinical ILD Curriculum & Culture Change to Genomic and Transcriptomic Analysis $16,457 $10,203 Cultivate Physicians for the Future (American Medical Association) of Breast and Ovarian Cancers Chin, Marshall H. Reducing Health Care Disparities Through Payment $103,897 $12,468 Genetics of African American Type 2 Diabetes $25,679 $15,921 and Delivery System Reform: Evaluation and Dissemination (Johnson Foundation) Melamed, Rachel Using clinical data to identify FDA-approved $116,142 $8,811 Expert Consulting for the Disparities Portfolio (PCORI) $63,550 $25,420 drugs for cancer prevention and therapeutic repurposing Laiteerapong, Neda Examining the U.S. cost-effectiveness of $125,455 $12,545 Perera, Minoli Health Disparity in Pharmacogenomics: $252,792 $142,279 alternative glycemic treatment algorithms

in the era of new medications Total PHS Research $3,001,131 $1,534,569 (American Diabetes Association) Peek, Monica Shared Decision Making amoung Vulnerable Populations: $128,974 $12,397 STATE/ASSOCIATION/FOUNDATION GRANTS The Confluence of Bioethics, Health Basu, Anindita Comparison, calibration, and benchmarking of $129,700 $19,455 Disparities and Medical Decision Making (Greenwall Foundation) high-throughput single cell RNASeq techniques Pincavage, Amber Evaluation of a Virtual Interactive $15,909 $1,591 for unbiased cell-type classification (Chan Zuckerberg Initiative) Platform in Enhancing Diagnostic Reasoning and Total State/Association/Foundation Grants $129,700 $19,455 Disparities and Medical Decision Making (Greenwall Foundation) Saunders, Milda R. Patient Referral and Education Program for Patients on) $10,000 $0 INDUSTRY GRANTS Renal Replacement Therapy (PREPP RRT Total Industry Grants $- $- (Central Society for Clinical and Translational Research) Stern, Scott D. C. I-Human Deployment (Manipal University) $68,753 $13,751 Total Sponsored Research FY14 FY15 FY16 FY17 FY18 Evaluation of Interactive Virtual Technology in $78,497 $7,850 Public Health Service $24,501,313 $7,067,316 $20,488,400 $1,441,126 $4,535,700 Diagnostic Reasoning and accuracy State/Association/Foundations $204,952 $149,155 $149,155 (The Marcus Foundation/American Medical Association) Industry Grants $125,000 $- Wan, Wen RQ10 for Gastroparesis and Constipation in $14,519 $3,630 TOTAL $24,706,265 $7,067,316 $20,762,555 $1,441,126 $4,684,855 Parkinson’s Disease * FY14-16 includes Grossman and Rzhetsky. (Michael J. Fox Foundation/Virginia Commonwealth University) Total State/Association/Foundation Grants $634,554 $89,652

2018 Annual Report 63 Total Total Sponsored Awards Research

Section of Geriatrics & Palliative Medicine Section of Hematology/Oncology PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE PUBLIC HEALTH SERVICE Huisingh-Scheetz, Megan J. Early Frailty Biomarkers: Patterns of Activity $144,702 $11,334 Churpek, Jane Defining the Role of BRCA1 in Hematopoiesis $151,800 $12,144 and Energy Expenditure - Resubmission 01 Dolan, Mary Eileen Pharmacogenomics of Childhood Leukemia ( ALL) $53,125 $30,813 Kostas, Tia Primary Care Medication Management for Vulnerable Populations $178,613 $14,289 Regulation of mRNA Splicing by Intronic Genetic Variants $83,390 $48,366 Levine, Stacie K. Illinois AHEC Network Program $12,490 $999 Genetic Susceptability and Biomarkers of Platinum-Related Toxicities $75,063 $43,537 Thompson, Katherine South Side Healthy Aging Resource Experts (SHARE) Network $713,959 $26,380 NCI Youth Enjoy Science Research Education Program (R25) - 2017 $393,593 $15,014 Total PHS Research $1,049,764 $53,002 Fleming, Gini Alliance for Clinical Trials in Oncology Operations Center $2,792,243 $725,983 Alliance NCORP Research Base $685,801 $178,308 STATE/ASSOCIATION/FOUNDATION GRANTS DOD Breast Cancer Research Program $28,505 $7,411 Levine, Stacie Hospice and Palliative Medicine $76,500 $- Geeleher, Paul Novel Computational Approaches for Pharmacogenomic Discovery $78,331 $6,266 Fellowship Program (Coleman Foundation) Kindler, Hedy U10 - NCTN (Lead) $401,708 $232,991 A Primary Palliative Care Education Program to $112,995 $- Larson, Richard A. Stopping Tyrosine Kinase Inhibitors in CMP Patients - $12,171 $7,546 Improve Access for Patients with Cancer – Phase III Lebeau, Michelle M. CCSG - CTRP Admin Suppl - P30CA014599-37S2 $2,758,304 $1,710,148 (Coleman Foundation) Molecular mechanisms of myeloid suppressor genes on chromosome 5 $228,750 $132,675 Total State/Association/Foundation Grants $189,495 $- A rapid spontaneous murine model of CN-AML $41,500 $24,070 Liu, Hongtao TC 557 Radiation Injury Treatment Network (RITN) Agreement FY17 $4,938 $3,062 INDUSTRY GRANTS Luke, Jason Genomic and Commensal Variants Associated with $117,037 $72,563 Levine, Stacie Hospice and Palliative Medicine Fellowship Program (VITAS) $68,182 $6,818 Immunotherapy in Cancer Patients Total Industry Grants $68,182 $6,818 Olopade, Olufunmilayo Developing an Oncology Workforce for the 21st Century $531,619 $41,010 Cancer Genetics Professional Education in a $23,981 $1,918 Total Sponsored Research FY14 FY15 FY16 FY17 FY18 Global Community of Practice Public Health Service $324,844 $177,767 $965,755 $926,928 $1,102,766 Returning Genetic Research Panel Results for $45,203 $26,218 State/Association/Foundations $364,472 $418,360 $371,767 $174,221 $189,495 Breast Cancer Susceptibility Industry Grants $75,000 $- $75,000 Case GI SPORE $21,577 $13,378 TOTAL $689,316 $596,127 $1,412,522 $1,101,149 $1,367,261 Africa Cancer Leaders Institute $30,000 $0 Pearson, Alexander T A Reasoned Approach to Combination $148,200 $11,856 Therapy Development in Head and Neck Cancer Ratain, Mark J. Clinical Therapeutics $471,038 $37,683 Sharma, Manish Genomic Prediction Tools Developed using $176,369 $14,110 Phenotypes from Disease Progression Models Computational Modeling of $20,949 $12,674 Tumor Burden by CT to Advance Cancer Therapeutics Smith, Sonali SWOG Network Group Operations Center of the NCTN $11,837 $6,865 Stadler, Walter M. SPORE in Prostate Cancer $319,004 $185,022 Stock, Wendy Center for Precision Medicine in Leukemia $81,495 $47,267 Sundaravel, Sriram Leveraging Epigenetic and Epitranscriptomic $45,544 $0 Aberrations in Cancer to Identify Molecular Targets for Designing Therapy Szmulewitz, Russell Z. SPORE in Prostate Cancer $50,000 $29,000 Thirman, Michael J. Ionizing Radiation-Induced Hematological Malignancies $36,000 $22,320 Instructive role of MLL Fusion Proteins in Lineage $502,591 $91,954 Determination and Leukemogenesis Total PHS Research $10,421,666 $3,792,172

2018 Annual Report 65 Total Total Sponsored Awards Research Section of Hematology/Oncology (Continued) PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED Section of Hematology/Oncology (Continued) STATE/ASSOCIATION/FOUNDATION GRANTS PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED Agyeman, Abena S. Using Hsp90 Inhibitors to Treat Triple Negative Breast cCncer $60,000 $0 STATE/ASSOCIATION/FOUNDATION GRANTS (Susan G. Komen Foundation) Pearson, Alexander T Live Cell Imaging of Head and Neck Cancer $37,500 $0 Conzen, Suzanne D. Use of Selective GR Antagnoists in Castration-resistant $500,000 $0 Stemness and Quiescence (Cancer Research Foundation) Prostate Cancer (Prostate Cancer Foundation) Stock, Wendy A phase Ill trial to Evaluate the Efficacy of the Addition of $490,647 $49,065 Curran, Emily K Investigating the role of the STING pathway in $37,500 $0 Inotuzumab Ozogamicin (a conjugated anti-CD22 monoclonal antibody) hereditary malignancies (Cancer Research Foundation) to Frontline Therapy in Young Adults (ages 18-39 years) Dolan, Mary Eileen Susan G. Komen Foundation - 2015 (Resubmission) $135,000 $0 with Newly Diagnosed Precursor B-Cell ALL (Susan G. Komen Foundation) (Alliance for Clinical Trials in Oncology Foundation) Drazer, Michael W Defining Leukemogenic Mechanisms in Hereditary $110,000 $0 Sweis, Randy F Targeting the non-T Cell Inflamed Tumor Microenvironment in) $47,501 $2,499 Hematologic Malignancies (Damon Runyan Foundation) Urothelial Bladder Cancer (Conquer Cancer Foundation Fleming, Gini DNA Repair Therapies for Ovarian Cancer $143,608 $15,956 Facilitating immuotherapy responses in non-T cell-inflamed $55,000 $0 (Ovarian Cancer Research Fund) bladder cancer (American Association for Cancer Research) Godley, Lucy CBC Program Management at The University of Chicago $125,000 $0 Innate immune activation to mediate tumor control in $37,500 $0 (Chicago Community Trust Searle Funds/ Northwestern University) bladder cancer (Cancer Research Foundation) Identification of Germline Predisposition Syndromes in $181,818 $18,182 Uppal, Sakshi The Impact of Hypoxia on Epigenetic Changes in $50,000 $0 Young MDS Patients (Taub Foundation) Neuroblastoma (Alex’s Lemonade Stand Foundation for Childhood Cancer) Modeling Myeloid Malignancies Mediated by Germline RUNX1, ETV6, $180,018 $19,982 Veneris, Jennifer Lynn Glucocorticoid Receptor-mediated Chemotherapy $47,501 $2,499 and ANKRD26 mutations (Leukemia & Lymphoma Foundation) Resistance in Ovarian Cancer (Conquer Cancer Foundation) CHEK2 mutations as predisposition alleles for inherited $50,000 $0 Wickrema, Amittha Therapeutic targeting of anemia in MDS by modulation $180,018 $19,982 hematopoietic malignancies (Cancer Research Foundation) of DOCK4 pathway (Leukemia & Lymphoma Foundation) The role of TET3 and HIF on 5-hmC status in $2,000 $0 Huo, Dezheng Genetic and Epigenetic Factors in Breast Cancer $208,333 $41,667 hypoxic erythropoiesis (American Society of Hematology) (Breast Cancer Research Foundation) Identifying Inherited Variants that Predispose $180,000 $20,000 Total State/Association/Foundation Grants $4,226,679 $301,080 to Lymphoid Malignancies (V Foundation) INDUSTRY GRANTS The Role of BRCA1 in Genomic Instability and Hematopoietic $2,000 $0 Curran, Emily K Immunologic Role of DDX41 in Development of Hereditary $59,091 $5,909 Malignancies (American Society of Hematology) Hematologic Malignancies (Gilead Sciences) Exploring the Impact of Germline Mutations on the Differentiation of $2,000 $0 Kline, Justin P. To Define and Overcome Immunoregulatory $12,341 $4,936 Mesenchymal Stromal Cells into Osteocytes Mechanisms Activated in Leukemia-bearing) Mice Treated with (American Society of Hematology) STING Agonist Immunotherapy (Merck S&D) Jakubowiak, Andrzej Multiple Myeloma Research Consortium Site Grant - Renewal 01 $53,750 $10,750 Role of TIGIT in T Cell Dysfunction in Leukaemia and $28,937 $11,575 (Multiple Myeloma Research Foundation) Lymphoma (Iteosthera) Lebeau, Michelle M. ACS Institutional Research Grant (American Cancer Society) $90,000 $0 Lim-Seiwert, Tanguy Immune characterization of head and neck $89,286 $35,714 Study of Myelodysplastic Syndromes - 2017 (Evans Foundation) $181,819 $18,181 squamous cell carcinomas (HNSCC) and Olopade, Olufunmilayo Genomic Approaches for Primary Prevention of Breast Cancer $80,000 $0 malignant Mesotheliomas to understand the role of ICOS and (American Cancer Society) mechanisms of resistance to anti-PD-1/PD-L1 based immunotherapies (JOUNCE) Translating Breast Cancer Genetics in the Clinic $160,000 $40,000 Luke, Jason Characterization of Siglec- 7/-9 Pathway Expression and $76,429 $30,571 (Susan G. Komen Foundation) Clinical Response to Cancer Immunotherapy (Palleon) Implementing Evidence Based Interventions to Reduce Breast Cancer $208,333 $41,667 Patnaik, Akash Perturbing DNA repair pathways to Enhance $275,102 $110,041 Mortality in Low Resource Settings Immune-responsiveness in Prostate Cancer (Bristol Myers Squibb) (Breast Cancer Research Foundation) Szmulewitz, Russell Z. Preclinical investigation of ABT-075 in the treatment of high $150,000 $60,000 Functional Analysis of SNPs associated $6,500 $650 glucocorticoid-receptor expressing with Estrogen Receptor Negative enzalutamide-resistant castration-resistant prostate cancer (AbbVie) Breast Cancer using CRISPR-Cas9 Technology (Doris Duke Charitable Trust) Total Clinical Trial Earnings $18,614,906 $4,653,727 Patnaik, Akash Combinatorial Immunotherapy Strategies to $500,000 $0 Total Industry Grants $19,306,092 $4,912,473 Reverse Immunosuppression within PTEN-deficient Advanced Prostate Cancers (Prostate Cancer Foundation) Total Sponsored Research FY 14 FY15 FY16 FY17 FY18 Combinatorial Immunotherapy Strategies to $58,333 $0 Public Health Service $18,429,021 $19,723,352 $15,721,229 $13,938,323 $14,213,838 Reverse Immunosuppression within State/Association/Foundations $5,136,773 $6,921,685 $3,220,776 $4,320,332 $4,527,759 PTEN-deficient Advanced rostateP Cancers (Phi Bets Psi Sorority) Industry Grants $15,648,868 $16,364,357 $17,059,908 $21,656,896 $24,218,565 Perturbing DNA Repair Pathways to Enhance $25,000 $0 TOTAL $39,214,662 $43,009,394 $36,001,913 $39,915,551 $42,960,162 Immune-responsiveness in Prostate Cancer (Cancer Research Foundation)

2018 Annual Report 67

Section of Infectious Diseases and Global Health PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE Eavou, Rebecca Comprehensive PrEP Retention in Care (PrEP-RC) $162,652 $16,265 Khanna, Aditya S. Assessing and Modeling Network-level Consequences $53,873 $33,401 of Patient Navigation McNulty, Moira C Employing eSBI in a Community-based $70,716 $41,015 HIV Testing Environment for At-risk Youth Towards Implementation of Hybridized HIV $12,233 $7,584 Testing Strategies to Optimize Care Continuum Metrics Pho, Mai Tuyet Optimizing Patient-Oriented Outcomes for $155,595 $90,245

Total Total Sponsored Awards Research Chronic Hepatitis C - Renewal 01 Section of Hospital Medicine Pre-Release Linkage to HCV, HIV, and $149,979 $92,985 PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED Addiction Services (PRELINK) PUBLIC HEALTH SERVICE Ending transmission of HIV, HCV, and STDs and $384,683 $204,516 Chattopadhyay, Ishanu ZeD: Zero-Knowledge Discovery Using Data Smashing $593,407 $201,152 overdose in rural communities of people who inject drugs (ETHIC) Gibbons, Robert Computerized Adaptive Testing of Suicidality in LGBT Young Adults $71,228 $28,663 Pisano, Jennifer C. Healthcare Associated Infection Prevention 2018 $16,261 $10,082 Peer-led Suicide Prevention: Promoting Healthy Role $44,887 $26,035 Pitrak, David University of Chicago Expanded HIV Testing and $1,037,032 $100,660 Transitions for Military Personnel Linkage to Care for Disproportionately Optimizing Youth Suicide Risk Screening in the $18,867 $10,943 Affected Populations in Healthcare Settings on the Emergency Department South Side and West Side of Chicago Bipolar-Schizophrenia Network for Intermediate Phenotypes $46,496 $24,184 Ridgway, Jessica P. Third Coast Center for AIDS Research $54,602 $33,853 Advanced Statistical Methods to Improve $83,463 $0 Anti-infective Stewardship using the Wisca tool in the $32,879 $19,070 Federal Surveillance of Medication Safety and Suicide Electronic Medical Record Meltzer, David Short Term Aging-Related Research Program $61,479 $4,918 CDPH Data to Care $63,864 $6,386 The University of Chicago Patient Centered $601,338 $48,107 Schneider, John A. HIV intervention Models for Criminal Justice involved $467,939 $161,959 Outcome Research K12 Training Program Substance-using Black MSM Changing Long-Term Care in America: Policies, $23,546 $13,657 HIV intervention Models for Criminal Justice involved $133,532 $15,390 Markets, Strategy & Outcomes Substance-using Black MSM Health Services Training Grant Subaward-Northwestern $238,734 $15,259 Accelerating PrEP Diffusion through Network Change Agents $228,385 $98,220 MD/PhD Program in Medicine, the Social Sciences and Aging $199,176 $9,214 Impact of Neighborhoods and Networks on HIV Risk and Care $195,687 $15,655 CMS Practice Transformation Network $133,820 $52,858 Comprehensive High Impact HIV Prevention Projects $231,093 $0 African American Cardiovascular pharmacogenetic $401,479 $232,858 for Community-Based Organizations CONsorTium (ACCOuNT): Discovery and Translation Center for Prevention Implementation Methodolgy for $51,048 $29,608 ITM 2.0: Advancing Translational Science in Metropolitan Chicago $498,300 $32,184 Drug use and HIV (FP065282-01-PR) - TL1 Component Insurance Coverage Expansion (ICE): A collaboration to $452,551 $134,888 Chicago HIDTA Public Health Analyst (PHA) $67,460 $17,540 increase and strengthen access to care among men and their networks Prochaska, Micah The Effect of Red Blood Cell Transfusion on Fatigue, $147,924 $11,834 PrEP Uptake and Adherence Among Young Black MSM: $304,644 $188,879 Activity and Fatigability in Hospitalized Patients with Anemia Neighborhood and Network Determinants Total PHS Research $3,231,604 $729,406 Keeping it LITE: Exploring HIV Risk in Vulnerable $47,354 $29,359 Youth with Limited Interaction STATE/ASSOCIATION/FOUNDATION GRANTS Syphilis in Chicago: Epidemiology, Sexual Networking $185,218 $112,057 Kuttab, Hani Pre-Hospital Focused Assessment with Sonography for Trauma) $2,500 $0 and Modeling for Prevention Next-Generation $572,806 $245,127 (FAST) and Time to the Operating Room (OR Phylodynamics-targeted Partner Service Models for Combined HIV Prevention (Air Medical Physician Association) Sherer, Renslow AIDS Education and Training Centers Program $18,519 $1,481 Martin, Shannon Understanding Associations of Maintenance of Certification $12,500 $0 Total PHS Research $5,083,145 $1,688,685 (MOC) on Resource Utilization and Physician-Reported Knowledge and Experience in Consultation (American Board of Medical Specialities) PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED STATE/ASSOCIATION/FOUNDATION GRANTS Meltzer, David CAPriCORN - Phase II (PCORI/CHI COMM) $80,576 $32,231 Eavou, Rebecca South Side Social Network Strategy (S4 Program) $141,036 $14,104 Longitudinal Effects of the Comprehensive Care $181,755 $18,176 (Center for Disease Control/Chicago Department of Public Health) Physicians Program (Donaghue Foundation) South Side PrEP Project (S2P2) $141,035 $14,104 Effects of Oral Health on Systemic Health, Oral Health & $508,291 $0 (Center for Disease Control/Chicago Department of Public Health) Healthcare Programs (George E. Richmond Foundation) Sherer, Renslow WUMER Project (Sino American Medical School, Wuhan University) $1,388,063 $0 Critical Time Intervention in a Criminal Justice Setting (LJAF) $333,151 $32,165 Total State/Association/Foundation Grants $1,670,134 $28,208 Longer Term Social and Cost Benefits of Early MH Treatment $66,964 $8,036 for Child Sexual Abuse Victims (Robert Wood Johnson Foundation) INDUSTRY GRANTS CAPriCORN - Phase II Subaward. (PCORI/Northwestern University ) $80,576 $32,231 Pitrak, David Expanded Testing and Linkage to Care (XTLC) (Gilead Sciences) $338,652 $33,865 Total State/Association/Foundation Grants $1,266,313 $122,839 Ridgway, Jessica P. GSK Database Study-DUA (Glaxo Smith Kline) $131,762 $52,705 Total Clinical Trial Earnings $357,074 $89,269 INDUSTRY GRANTS Total Industry Grants $827,488 $175,839 Edelson, Dana eCART Lite: Detecting Clinical Deterioration in the $82,143 $32,857 Continuous Monitoring Data (EARLYSENSE) Total Sponsored Research FY14 FY15 FY16 FY17 FY18 Hospital Using Limited Clinical Variables and Public Health Service $1,185,772 $2,006,111 $4,939,253 4,375,800 $6,771,830 Total Clinical Trial Earnings $82,143 $32,857 State/Association/Foundations $580,038 $1,582,822 $1,533,603 1,369,719 $1,698,342 Total Industry Grants $82,143 $32,857 Industry Grants $1,362,267 $1,476,058 $950,764 192,027 $1,003,327 TOTAL $3,128,077 $5,064,991 $7,423,620 5,937,546 $9,473,499 Total Sponsored Research FY14 FY15 FY16 FY17 FY18 Public Health Service $4,207,548 $4,519,439 $3,666,163 $5,092,695 $3,961,010 State/Association/Foundations $405,711 $1,444,109 $1,177,457 $1,551,425 $1,389,152 Industry Grants $124,920 $371,813 $- $115,000 2018 Annual Report 69 TOTAL $4,613,259 $6,088,468 $5,215,433 $6,644,120 $5,465,162 Section of Pulmonary/Critical Care (Continued) PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE Mutlu, Gokhan M. Macrophage Responses to Epithelial $34,433 $19,971 Dysfunction Promote Lung Fibrosis in Aging Particulate Matter-Induced Changes in DNA $391,005 $226,783 Methylome and Transcriptome The Role of Alveolar Macrophage Beta-2 Adrenergic $400,000 $232,000 Receptors in Acute Lung Injury Noth, Imre Study of Co-trimoxazole and Proton Pump Inhibition Using $8,157 $4,731 Pragmatic Design in Idiopathic Pulmonary Fibrosis - CleanUP-IPF Architectural Structure and Regulation of TOLLIP in IPF $507,056 $287,982 Olopade, Christopher O. Summer Program to Increase Diversity in Biomedical $129,700 $10,376 Research & Physician Workforce Total Total Sponsored Awards Research Solway, Julian Mendelian Disease – Asthma Comorbidity to Find $498,852 $270,147 Subgroup-Specific Asthma Genes TET1-mediated $25,000 $14,500 5-hydroxymethylcytosine Modification and Airway Hyperresponsiveness Preclinical development of myosolvins, $1 $0 a new class of medicine for asthma Section of Nephrology ITM 2.0: Advancing Translational Science in Metropolitan Chicago $4,166,342 $1,671,288 PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED Sperling, Anne I. Research Training in Respiratory Biology $676,948 $50,516 PUBLIC HEALTH SERVICE Chapman, Arlene Beth A Metabolomic Approach to Discovering Markers for $28,401 $16,473 IRF4+ Respiratory Rendritic Cells in type 2 Inflammatory Responses $250,000 $149,048 ADPKD Progression Tasali, Esra Fatma Sleep Extension To Reduce Diabetes and Obesity Risk $384,621 $169,925 Kansas PKD Research and Translation Core Center $28,171 $13,280 Verhoef, Philip Type 2 Immune Responses Protect Against the $151,800 $12,144 Consortium for Radiologic Imaging Studies of $62,656 $34,477 Morbidity and Mortality of Sepsis Polycystic Kidney Disease (CRISP) IV: Prognosis White, Steven Azithromycin and the Airway Microbiome in Asthma $277,941 $97,217 for End-Stage Renal Disease and Biomarker Validation Chicago Metropolitan Asthma Consortium for $273,616 $113,760 Hassan, Hatim A. Calcium Oxalate Kidney Stones: Pathogenesis of $217,500 $126,150 Severe/Exacerbation-Prone Asthma Obesity-associated Hyperoxaluria Total PHS Research $9,619,246 $3,937,984 Koyner, Jay L. Intrarenal Oxygenation: An Early Marker $6,338 $3,675 STATE/ASSOCIATION/FOUNDATION GRANTS for Risk of Developing AKI Guzy, Robert David FGF regulation of myofibroblast differentiation $40,000 $0 Worcester, Elaine M. Pathogenesis of Calcium Nephrolithasis $46,120 $28,594 (American Lung Association) Pathogenesis of Calcium Nephrolithasis $1,163,225 $283,274 FGF Regulation of Myofibroblast Differentiation $10,000 $0 Total PHS Research $1,552,411 $505,923 (Central Society for Clinical and Translational Research) Mechanism of Gremlin-1 in the Development of $21,739 $3,261 STATE/ASSOCIATION/FOUNDATION GRANTS Pulmonary Fibrosis (Pulmonary Fibrosis Foundation) Ko, Benjamin S. Kidney TREKS Program (American Society of Nephrology) $90,000 $0 Educational Award (Embassy of the Arab Republic of Egypt) $7,000 $0 Kidney TREKS Program (American Society of Nephrology) $90,000 $0 Hamanaka, Robert Metabolic Regulation of lung fibrosis (American horacicT Society) $40,000 $0 Total State/Association/Foundation Grants $180,000 $0 Hoddy, Kristin The Microbiome as a Mediating link between the $1,000 $0 Effect of Diet Quality on Sleep Quality INDUSTRY GRANTS Hassan, Hatim A. Therapeutic Potential of Oxalobacter formigenes-derived Factors $78,572 $31,428 (Dietitians in Integrative and Functional Medicine) for Hyperoxaluria, Hyperoxalemia, and related Kidney Stones (OXALO) Krishack, Paulette Type 2 Inflammatory Response Protects Against $50,350 $0 Total Clinical Trial Earnings $328,967 $82,242 Staphylococcus aureus Induced Sepsis Total Industry Grants $407,539 $113,670 (American Heart Association (Midwest) Naureckas, Edward American Lung Association Asthma Clinical Research Network $19,246 $0 Total Sponsored Research FY14 FY15 FY16 FY17 FY18 (American Lung Association) Public Health Service $2,623,945 $3,268,846 $1,931,796 $652,272 $2,058,334 Cystic Fibrosis Foundation Practice Guidelines Update $26,018 $0 State/Association/Foundations $6,900 $404,067 $687,377 $- $180,000 (Cystic Fibrosis Foundation) Industry Grants $114,900 $313,974 $279,439 $248,554 $521,209 Award for a Mental Health Coordinator (Cystic Fibrosis Foundation) $50,000 $4,000 TOTAL $2,745,745 $3,986,887 $2,898,612 $900,826 $2,759,543 Patel, Bhakti Impact of early mobilization on insulin resistance and $52,000 $0 ICU-acquired weakness (Parker B. Francis Foundation) Total State/Association/Foundation Grants $317,353 $7,261 Section of Pulmonary/Critical Care PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED INDUSTRY GRANTS PUBLIC HEALTH SERVICE Dulin, Nickolai Testing Compounds for Efficacy Against $41,142 $16,457 Camacho, Daniel IRF4+ Respiratory Dendritic Cells in type 2 Inflammatory Responses $49,044 $0 Pulmonary Fibrosis (Seguetx) Churpek, Matthew M. Predicting In-hospital Cardiac Arrest Using Electronic Health $151,800 $12,144 Hogarth, Douglas Kyle Interventional Pulmonology Fellowship at $25,000 $0 Record Data Sepsis Early Prediction and Subphenotype $255,669 $130,123 The University of Chicago (Medtronic) Illumination Study (SEPSIS) Interventional Pulmonology Fellowship at $30,000 $0 Fang, Yun Coronary Artery Disease locus 1p32.2 and miR92a-PPAP2B $250,000 $149,048 The University of Chicago (Boston Scientific) Signaling in Endothelial Mechanobiology Total Clinical Trial Earnings $322,491 $80,623 Coronary Artery Disease locus 1p32.2 and $250,000 $149,048 Total Industry Grants $418,633 $97,080 miR92a-PPAP2B Signaling in Endothelial Mechanobiology Spatial Delivery of microRNA Inhibitor via Targeted $250,000 $144,766 Total Sponsored Research FY14 FY15 FY16 FY17 FY18 Polyelectrolyte Complex Micelles to Treat Atherosclerosis. Public Health Service $12,594,100 $14,426,748 $17,680,416 $9,940,793 $13,557,230 Guzy, Robert David Mechanism of Fibroblast Growth Factor $151,800 $12,144 State/Association/Foundations $71,971 $316,361 $818,564 $396,894 $324,614 2-Mediated Alveolar Epithelial Repair Industry Grants $874,585 $756,872 $855,821 $681,125 $515,713 Hamanaka, Robert Metabolic Regulation of Epidermal Homeostasis $78,488 $6,279 TOTAL $13,540,656 $15,499,981 $19,354,801 $11,018,812 $14,397,557 Mokhlesi, Babak TODAY2 Phase 2 (T2P2): Long-Term $6,973 $4,044 Post-Intervention Follow-Up Study

2018 Annual Report 71 Total Total Sponsored Awards Research

Section of Rheumatology Section of Rheumatology (Continued) PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE INDUSTRY GRANTS Alegre, Maria-Luisa Infections and The Stability of Transplantation Tolerance $980,000 $607,600 Total Clinical Trial Earnings $101,800 $25,450 Impact of Microbiota on Alloimmune Responses in Transplantation $250,000 $139,432 Total Industry Grants $101,800 $25,450 The Microbiota and Allograft Rejection: Novel Investigations $83,333 $51,666 into the Consequences of Obesity Total Sponsored Research FY14 FY15 FY16 FY17 FY18 Clark, Marcus Ramsay In situ Adaptive Immunity in Human Lupus Tubulointerstitial Nephritis $220,000 $127,600 Public Health Service $4,771,826 $6,847,760 $5,846,364 $5,871,237 $7,392,784 University of Chicago Autoimmunity Center of Excellence $241,435 $134,464 State/Association/Foundations $266,759 $206,759 $381,356 $71,394 $400,950 Medical Scientist National Research Service Award $1,183,435 $54,350 Industry Grants $262,105 $179,652 $127,250 $28,901 $127,250 TOTAL $5,300,690 $7,234,171 $6,354,970 $5,971,532 $7,920,984 Regulation of Ig-kappa recombination during B lymphopoiesis $297,607 $164,244 BRWD1 in Adaptive Humoral Immunity $125,000 $77,500

Autoimmunity Center of Excellence Clinical $265,037 $158,371 Sponsored Research for the Department of Medicine Grand Total FY14 FY15 FY16 FY17 FY18 Research Program - Collaborative Project Public Health Service $91,532,042 $79,503,794 $93,449,876 $63,889,941 $83,346,963 Gounari, Fotini How beta-catenin Expands Foxp3+RORgammat+ $294,082 $103,602 State/Association/Foundations $13,521,116 $16,926,325 $12,480,096 $11,199,945 $11,904,392 Pro-inflammatory T-regulatory Cells Industry Grants $22,810,425 $24,457,913 $23,656,805 $27,974,511 $31,920,989 Liarski, Vladimir Michael Characterizing in situ T Cell:Dendritic Cell Networks in $150,641 $12,052 Total $127,863,583 $120,888,032 $129,586,777 $103,064,397 $127,172,344 Human Lupus Nephritis and Renal Allograft Rejection Wilson, Patrick C. Vaccine Induced Immunity in the Young and Aged $66,537 $38,591 System Biological Analysis of Innate and Adaptive $85,803 $44,197 Responses to Vaccination NIAID Centers of Excellence in Influenza Research and Surveillance $24,691 $15,309 NIAID Centers of Excellence in Influenza Research and Surveillance $391,400 $227,012 Evaluating the Role of Immunodominant Epitopes in $123,457 $76,543 Limiting B Cell Responses upon Repeated Influenza Vaccination Mechanisms of Broadly Neutralizing Humoral $344,519 $199,821 Immunity Against Influenza Viruses Studies of Human B Cell Tolerance, from a $11,679 $6,774 Humanized Mouse Model to Human Beings Impact of Prior Influenza Exposures on $9,494 $5,506 Antibody Repertoires to New Viral Strains Total Public Health Service Grants $5,148,150 $2,244,634 STATE/ASSOCIATION/FOUNDATION GRANTS Dua, Anisha B. Amgen Fellowship Training Award (RRF) $50,000 $0 Gounari, Fotini Tracing mechanisms of genomic instability induced $150,000 $0 by beta-catenin (American Society of Hematology) Ko, Kichul Lupus Clinical Investigators Network (LuCIN) $40,000 $0 (Alliance for Lupus Research) Lei, Yuk Man The Role of Microbiota in Allograft Rejection - $25,950 $0 Resubmission 02 (American Heart Association (Midwest)) Mathur, Priya Transcriptional and epigenetic roles for $57,143 $2,857 ß-catenin in the Genomic Instability and Oncogenic Transformation of T-cell Leukemia/Lymphoma (Leukemia & Lymphoma Foundation) Wilson, Patrick C. Evaluation of Safety and Immunogenicity of chimeric $68,182 $6,818 HA Expressing Live-Attenuated and Inactivated Universal Influenza Virus Vaccines in Phase I Clinical rialsT (Gates Foundation) Total State/Association/Foundation Grants $391,275 $9,675

2018 Annual Report 73