ARMET Polyclonal Antibody

ARMET polyclonal antibody

Catalog # : PAB13301 規格 : [ 100 ug ] List All

Specification Application Image

Product Rabbit polyclonal antibody raised against synthetic peptide of ARMET. Western Blot (Tissue lysate) Description:

Immunogen: A synthetic peptide corresponding to C-terminus 12 amino acids of human ARMET.

Host: Rabbit enlarge

Reactivity: Human, Mouse, Rat Immunohistochemistry (Formalin/PFA-fixed paraffin- Form: Liquid embedded sections)

Recommend Western Blot (1-2 ug/mL) Usage: The optimal working dilution should be determined by the end user.

Storage Buffer: In PBS (0.02% sodium azide) enlarge Storage Store at 4°C for three months. For long term storage store at -20°C. Instruction: Aliquot to avoid repeated freezing and thawing.

Note: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Datasheet: Download

Publication Reference 1. Role of IRE1α in podocyte proteostasis and mitochondrial health. José R Navarro-Betancourt, Joan Papillon, Julie Guillemette, Takao Iwawaki, Chen- Fang Chung, Andrey V Cybulsky.Cell Death Discov. 2020 Nov 19;6(1):128. doi: 10.1038/s41420-020-00361-4. 2. A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome. Mahadevan J, Morikawa S, Yagi T, Abreu D, Lu S, Kanekura K, Brown CM, Urano F.Lab Invest. 2020 Sep;100(9):1197-1207. doi: 10.1038/s41374-020-0436-1. Epub 2020 May 4. 3. Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress-Related Kidney Diseases. Kim Y, Lee H, Manson SR, Lindahl M, Evans B, Miner JH, Urano F, Chen YM.J Am Soc Nephrol. 2016 Oct;27(10):2974-2982. Epub 2016 Mar 3. 4. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Lindholm P, Voutilainen MH, Lauren J, Peranen J, Leppanen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M.Nature. 2007 Jul 5;448(7149):73-7. 5. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. Petrova P, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire AE, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW.J Mol Neurosci. 2003 Apr;20(2):173-88. 6. Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck. Shridhar R, Shridhar V, Rivard S, Siegfried JM, Pietraszkiewicz H, Ensley J, Pauley R, Page 1 of 3 2021/6/19 Grignon D, Sakr W, Miller OJ, Smith DI.Cancer Res. 1996 Dec 15;56(24):5576-8.

Applications Western Blot (Tissue lysate)

Western blot analysis of ARMET in mouse brain tissue lysate with ARMET polyclonal antibody (Cat # PAB13301) at (A) 1 and (B) 2 ug/mL .

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemistry of ARMET in human brain tissue with ARMET polyclonal antibody (Cat # PAB13301) at 2.5 ug/mL .

Gene Information

Entrez GeneID: 7873

Protein P55145 Accession#:

Gene Name: ARMET

Gene Alias: ARP,MANF,MGC142148,MGC142150

Gene arginine-rich, mutated in early stage tumors Description:

Omim ID: 260350, 601916

Gene Ontology: Hyperlink

Gene Summary: The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. With the protein size correction, this codon is now identified as the initiation codon. [provided by RefSeq

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