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Proceedings OF THE National Academy of Sciences OF THE OF AMERICA

Officers BRUCE ALBERTS, President of the JACK HALPERN, Vice President Academy PETER H. RAVEN, Home Secretary JAMES B. WYNGAARDEN, Foreign Secretary MILDRED S. DRESSELHAUS, Treasurer Editorial Board LAWRENCE BOGORAD, Chairman of the JAMES E. DARNELL, JR. ERIC R. KANDEL HERBERT A. SIMON Proceedings IGOR B. DAWID PHILIP W. MAJERUS MAXINE F. SINGER RONALD L. GRAHAM DAVID D. SABATINI IRVING L. WEISSMAN GORDON G. HAMMES PAUL R. SCHIMMEL SHERMAN M. WEISSMAN

Senior Contributing MICHAEL T. CLEGG, JAMES E. DARNELL, JR., RAYMOND L. ERIKSON, RONALD M. EVANS, Editors: ERIC R. KANDEL, RICHARD A. LERNER, DAVID J. L. LUCK, PHIL W. MAJERUS, ARNO G. MOTULSKY, DAVID D. SABATINI, PAUL R. SCHIMMEL, ALLAN C. SPRADLING, JAMES A. SPUDICH, CHARLES F. STEVENS, IRVING L. WEISSMAN, SHERMAN M. WEISSMAN Contributing Editors: MAX D. COOPER, HERMAN N. EISEN, WILLIAM E. PAUL Consulting Editors: JOSEPH L. GOLDSTEIN, RONALD GRAHAM, JACK HALPERN, JOANNE STUBBE

Managing Editor: FRANCES R. ZWANZIG Senior Associate Editor: GARY T. COCKS Associate Editors: CAY BUTLER, JOHN M. MALLOY, MARILYN J. MASON, JANET L. MORGAN, T. PEARSON, DOROTHY P. SMITH, COLENE RUCH WALDEN Assistant Managing Editor: JOANNE D'AMICO Senior Production Editor: BARBARA A. BACON Production Editors: JAMIE M. FEAR, BILL FOGLE, ELLEN GOLDBERG, SCOTT C. HERMAN, AIJA OZOLINS, KATHLEEN RUBY, ANNE M. SUNDERMANN, DON C. TIPPMAN Proofreader: MARY E. MCLAUGHLIN Administrative Assistants: DELORES BANKS, BRENDA L. McCoY Manuscript Coordinator: JACQUELINE PERRY Circulation: JULIA LITTLE, CYNTHIA MATHEWS

Editorial Correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Wash- ington, DC 20418. Business Correspondence: Circulation Office of the PROCEEDINGS, National Academy of Sciences, 2101 Constitution Avenue, Washington, DC 20418. Information for Contributors: See p. i (of this issue) and pp. iii-x of Issue Number 1, January 4, 1994. Copyright: Volumes 90 and 91, copyright 1993 and 1994 by the National Academy of Sciences; Volumes 1-89, copyright as a collective work only with copyright to individual articles retained by the author(s). Requests for permission to reproduce parts of individual articles published in Volumes 1-89 or for reprints of those articles should be addressed to the authors. Microforms of complete volumes are available to regular subscribers only and may be obtained from University Microfilms, Xerox Corporation, Ann Arbor, MI 48103. This journal is printed on acid-free paper effective with Volume 84, Issue 1. Subscriptions: All correspondence concerning subscriptions should be addressed to the Circulation Office of the PROCEED- INGS. Subscriptions are entered on a calendar year basis only. For 1994, subscription rates are as follows-in the United States: personal, $230; institutional, $420; elsewhere by surface mail: personal, $325; institutional, $515; elsewhere by Air Cargo at a surcharge of $192. Information regarding other air mail postage rates is available from the Circulation Office. Subscribers are requested to notify the Circulation Office of the PROCEEDINGS 6 weeks in advance of any change of address; also the local postmaster. The Academy is not responsible for nonreceipt ofissues because ofan improper address unless a change ofaddress is on file. The notice of address change should list both the old and new addresses. Claims for replacement copies will not be honored more than 60 days after the issue date for domestic subscribers and not more than 90 days after the issue date for foreign subscribers. Single Copies: The price of a single issue is $25.00. Second class postage paid at Washington, DC, and at additional mailing offices. PRINTED IN THE USA PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (ISSN-0027-8424) is published biweekly by THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Washington, DC 20418. X 1994 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. POSTMASTER: Send address changes to: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2101 Constitution Ave., Washington, DC 20418. Proc. Nail. Acad. Sci. USA Vol. 91, February 1994

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i AUTHOR INDEX, FEBRUAR Y 1, 1994

Aaronson, S. A. 989 Colanzi, A. 1114 Hammel, J. 903 Aaronson, S. A. 1074 Comeau, M. R. 1119 Hammond, C. 913 Abraham, J. A. 1069 Cooper, M. D. 1094 Hashimoto, K.-i. 1124 Adams, B. A. 1014 Corda, D. 1114 Hauser, C. A. 873 Adler, R. 974 Corey, J. L. 1188 Hayami, M. 1124 Aebersold, R. 1094 Cosman, D. 1119 Hegerl, R. 836 Agadir, A. 1178 Cowman, A. F. 1143 Heinemann, S. H. 1109 Alarid, E. T. 1074 Crapo, J. 1044 Helenius, A. 913 Albers, M. W. 984 Cunha, G. R. 1074 Henry, A. H. 969 Alberte, R. S. 1049 Cunningham, J. 1168 Herrick, G. 942 Allevato, G. 957 Dall'Acqua, W. 1089 Heurteaux, C. 878 Ames, B. N. 1183 Darwish, H. M. 900 Hirth, C. G. 1193 Arr6, M. 927 Davidson, N. 1188 Hoh, J. H. 836 Aruffo, A. 1099 De, A. 1084 Hollenbaugh, D. 1099 Astrom, A. 979 Debanne, D. 1148 Hood, L. 1094 Astrom, J. 979 De Francesco, R. 888 Hozumi, N. 1138 Balcells, L. 927 Degos, L. 1178 Huber, B. 1138 Baldi, P. 1059 DeLuca, H. F. 900 Hunkapiller, T. 1059 Baltimore, D. 1104 De Matteis, M. A. 1114 Ido, E. 1124 Bannykh, S. 1114 Der, C. J. 873 Igarashi, T. 1124 Barbas, C. F., III 1193 Deutscher, M. P. 964 Imoto, K. 1014 Barrantes, R. 1158 Di Girolamo, M. 1114 Ina, Y. 1124 Basbaum, A. I. 1009 Di Tullio, G. 1114 Ishida, T. 1124 Bauer, J. 1193 Djiane, J. 957 Jaffer, A. 947 Baumeister, W. 836 Doak, T. G. 942 Jahn, C. L. 942 Beam, K. G. 1014 Doerder, F. P. 942 James, S. L. 999 Befort, K. 1193 Dosanjh, M. K. 1024 Jamieson, L. 839 Bennetzen, J. L. 863 Eddy, R. 1168 Jasmin, L. 1009 Bentley, G. A. 1089 Edery, M. 957 Johann, S. V. 1168 Bhat, T. N. 1089 Edwards, K. J. 863 Johnson, J. P. 893 Bindereif, A. 903 Ehrhard, P. B. 1193 Joliot, A. 1034 Birchmeier, C. 1064 Eismann, E. 1109 Joliot, P. 1034 Blattler, W. A. 969 Elder, J. F., Jr. 994 Jones, M. 858 Bois, P. 878 Eltoum, I. 999 Kakeda, M. 1054 Boller, T. 952 Engel, A. 836 Kang, J. 1138 Boon, T. 1004 Englesberg, E. 858 Karrasch, S. 836 Boronat, A. 927 Enjuto, M. 927 Kaupp, U. B. 1109 Bottaro, D. P. 989 Failla, C. 888 Keddy, C. A. 969 Boulot, G. 1089 Fain, S. R. 1049 Kelly, P. A. 957 Bourbonniere, M. 844 Fajer, P. G. 937 Khan, S. H. 848 Braakman, I. 913 Farrington, M. 1099 Kieffer, B. L. 1193 Bradley, W. A. 1044 Feldman, D. 922 Kim, E. 1024 Briscoe, P. 1044 Feldman, M. W. 1079 Kim, Y.-G. 883 Broadus, A. E. 1133 Felix, G. 952 Klagsbrun, M. 1069 Brock, T. A. 1044 Fidy, J. 1029 Kobayashi, I. 1173 Brown, D. G. 1084 Fischer, S. H. 1099 Krauss, R. M. 1183 Brown, J. L. 1009 Fraenkel-Conrat, H. 1024 Krishnan, A. V. 922 Burgers, P. M. J. 868 Freeman, B. A. 1044 Ku, D. 1044 Burgess, W. H. 989 Freemont, P. S. 1084 Kubota, T. 1094 Burioni, R. 1193 Friedrich, J. 1029 Kuo, C.-l. 1094 Burton, D. R. 1193 Friend, D. 1119 Kusano, K. 1173 Caelles, C. 927 Fuchs, E. 1133 Lahti, J. 1094 Caldwell, J. 839 Fukunaga, T. 1124 Lambert, J. M. 969 Campos, N. 927 Funahashi, S.-i. 1124 La Monica, N. 888 Carr, M. 1084 Gafert, J. 1029 LaMont, J. T. 947 Cartier, L. 1124 Gahwiler, B. H. 1148 Landweber, L. F. 918 Caspar, P. 999 Galatis, D. 1143 Lane, W. S. 908 Castagliuolo, I. 947 Ganter, U. 1193 LaRochelle, W. J. 989 Chait, A. 1183 Garin-Chesa, P. 1004 Lazdunski, M. 878 Chambers, C. A. 1138 Gavdriaux-Ruff, C. 1193 Le Cam, A. 957 Chandrasegaran, S. 883 Gearing, D. P. 1119 Ledbetter, J. A. 1099 Chang, L.-Y. 1044 Gianturco, S. H. 1044 Leeman, S. E. 947 Chantler, P. D. 853 Gilbert, W. 918 Lester, H. A. 1188 Chauvin, Y. 1059 Gobel, T. W. F. 1094 Lewis, D. M. 1183 Chedid, M. 1074 Gojobori, T. 1124 Li, D. 853 Chen, C.-H. 839 Goldmacher, V. S. 969 Li, X. 868 Chen, C.-I. H. 1094 Gore, J. 1044 Liu, H. 1009 Chen, S.-J. 1178 Gorman, M. A. 1084 Liu, J. 908 Chen, Y. 1004 Goujon, L. 957 Luan, S. 984 Chen, Y.-T. 1004 Greene, M. I. 1089 Luini, A. 1114 Chen, Z. 1178 Gronvik, K.-O. 979 McClure, M. A. 1059 Chenna, A. 1024 Grosmaire, L. S. 1099 McDonald, L. J. 1114 Cheon, H.-G. 989 Guastella, J. 1188 Madani, N. D. 922 Chomienne, C. 1178 Guidez, F. 1178 Maggio, J. E. 1009 Christiansen, F. B. 1079 Guild, B. C. 969 Maki, R. 873 Clark, J. 957 Gupta, R. S. 858 Malloy, P. J. 922 Closs, E. 1168 Gustafsson, J.-A. 1019 Mantyh, P. W. 1009 ix AUTHOR INDEX, FEBRUARY 1, 1994

Mariuzza, R. A. 1089 Rancourt, C. 844 Takahashi, N. 1173 Masat, L. 893 Rees, A. R. 969 Tarpey, M. M. 1044 Menssen, R. 903 Regenass, M. 952 Tello, D. 1089 Meyer, D. 1064 Rettig, W. J. 1004 Thoma, B. 1119 Miller, J. F. 1163 Rodriquez-Pombo, P. 922 Thompson, J. K. 1143 Miller, M. 853 Roguska, M. A. 969 Thompson, S. M. 1148 Milstone, L. M. 1133 Romey, G. 878 Thuresson, A.-C. 979 Miura, T. 1124 Ron, D. 839 Tihanyi, K. 844 Mizuno, T. 1054 Ron, D. 1074 Tomei, L. 888 Mochly-Rosen, D. 839 Ross, R. 1069 Torroni, A. 1158 Moinier, D. 878 Rousselot, P. 1178 Tramontano, A. 888 Mosley, B. 1119 Roy, D. 1128 Tribble, D. L. 1183 Moss, J. 1114 Rubin, H. 1039 Turner, B. J. 994 Motchnik, P. A. 1183 Rubin, J. S. 1074 Ueda, S. 1124 Muller, F. 1109 Rubinstein, P. 1104 Ueguchi, C. 1054 Nagy, A. 1138 Saksela, K. 1104 Uhl, M.A. 1163 Nakai, J. 1014 Samson, L. 1024 Umezawa, A. 873 Nakano, T. 1069 Sanderson, M. R. 1084 van den Berg, J. J. M. 1183 Nathans, J. 974 Sanna, P. P. 1193 van der Bruggen, P. 1004 Neel, J. V. 1158 Santini, G. 1114 Vanderkooi, J. 1029- Negrutskii, B. S. 964 Sardana, M. 888 van Zejl, M. 1168 Nielsen, J. H. 957 Saunders, J. C. 1153 Verdine, G. L. 908 Noelle, R. J. 1099 Schindler, M. 1128 Vigna, S. R. 1009 Nonoyama, S. 1099 Schreiber, S. L. 984 Virtanen, A. 979 Ochs, H. D. 1099 Schurr, T. G. 1158 Wabl, M. 893 O'Hara, B. 1168 Schwartz, B. 999 Wallace, D. C. 1158 O'Keane, J. C. 947 Schwarz, F. P. 1089 Wang, Z.-Y. 1178 Old, L. J. 1004 Schweitz, H. 878 Warner, M. 1019 Orr, E. 839 Searle, S. J. 969 Washio, K. 1124 Osame, M. 1124 Segal, I. E. 962 Waxman, S. 1178 Oshima, R. G. 873 Sher, A. 999 Weber, J. M. 844 Oswald, I. P. 999 Shows, T. B. 1168 Weiss, K. M. 833 Otten, U. 1193 Simon, S. 1128 White, C. R. 1044 Pae, S. S. 1153 Simonin, G. 957 Williamson, R. A. 1193 Pallas, M. 1114 Singer, B. 1024 Wolff, T. 903 Pankov, R. 873 Singhal, B. S. 1124 Wood, T. 888 Paquereau, L. 957 Snider, R. M. 947 Wynn, T. A. 999 Park, L. 1119 Sodeoka, M. 908 Wysolmerski, J. J. 1133 Partridge, L. J. 1193 Sonoda, S. 1124 Yamada, H. 1054 Paulin, D. 999 Sorof, S. 848 Yamashita, M. 1124 Pauling, L. 897 Souchon, H. 1089 Yoshida, M. 1124 Pawling, J. 1138 Spanu, P. 952 Yoshikura, H. 1173 Pedersen, J. T. 969 Springer, P. S. 863 Young, P. 1074 Perbal, B. 932 Stalder, A. 1193 Zaninovic, V. 1124 Philbrick, W. M. 1133 Stapulionis, R. 964 Zelent, A. 1178 Pizzi, E. 888 Stevens, C. 1104 Zhivotovsky, L. A. 1079 Poljak, R. J. 1089 Stockert, E. 1004 Zhou, J. 1133 Portera-Cailliau, C. 974 Suba, G. K. 1049 Zhou, Z. 962 Postel-Vinay, M.-C. 957 Sung, C.-H. 974 Ziegler, S. F. 1119 Pothoulakis, C. 947 Sunohara, Y. 1173 Zierold, C. 900 Procaccini, G. 1049 Sureau, A. 932 Zimmerman, R. C. 1049 Quick, M. W. 1188 Tajima, K. 1124 Zollfrank, J. 1029 Raines, E. W. 1069

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