International Journal of Molecular Sciences Review Carotenoid Cleavage Oxygenases from Microbes and Photosynthetic Organisms: Features and Functions Oussama Ahrazem 1, Lourdes Gómez-Gómez 1, María J. Rodrigo 2, Javier Avalos 3 and María Carmen Limón 3,* 1 Instituto Botánico, Departamento de Ciencia y Tecnología Agroforestal y Genética, Facultad de Farmacia, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain;
[email protected] (O.A.);
[email protected] (L.G.-G.) 2 Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Departamento de Ciencia de los Alimentos, Calle Catedrático Agustín Escardino 7, 46980 Paterna, Spain;
[email protected] 3 Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Avenida Reina Mercedes 6, 41012 Sevilla, Spain;
[email protected] * Correspondence:
[email protected]; Tel.: +34-954-555947 Academic Editor: Vladimír Kˇren Received: 5 September 2016; Accepted: 8 October 2016; Published: 26 October 2016 Abstract: Apocarotenoids are carotenoid-derived compounds widespread in all major taxonomic groups, where they play important roles in different physiological processes. In addition, apocarotenoids include compounds with high economic value in food and cosmetics industries. Apocarotenoid biosynthesis starts with the action of carotenoid cleavage dioxygenases (CCDs), a family of non-heme iron enzymes that catalyze the oxidative cleavage of carbon–carbon double bonds in carotenoid backbones through a similar molecular mechanism, generating aldehyde or ketone groups in the cleaving ends. From the identification of the first CCD enzyme in plants, an increasing number of CCDs have been identified in many other species, including microorganisms, proving to be a ubiquitously distributed and evolutionarily conserved enzymatic family.