BOARD OF DIRECTORS

Warren K. Bickel, PhD, President William L. Dewey, PhD Chris-Ellyn Johanson, PhD, Past-President Nicholas E. Goeders, PhD Kathryn A. Cunningham, PhD, President-Elect Martin Y. Iguchi, PhD Dorothy K. Hatsukami, PhD, Treasurer Sari Izenwasser, PhD Leslie Amass, PhD Herbert D. Kleber, MD James C. Anthony, PhD Thomas R. Kosten, MD Nancy A. Ator, PhD Horace H. Loh, PhD Anna Rose Childress, PhD S. Stevens Negus, PhD Thomas J. Crowley, MD Sharon Walsh, PhD Samuel A. Deadwyler, PhD

EXECUTIVE OFFICER

Martin W. Adler, PhD

SCIENTIFIC PROGRAM COMMITTEE

Sharon Walsh, PhD, Chair Scott E. Lukas, PhD, Past-Chair Martin W. Adler, PhD, ex officio Ellen B. Geller, MA, ex officio Patrick Beardsley, PhD Richard Glennon, PhD Leonard Handelsman, MD Arthur Horton, EdD Sari Izenwasser, PhD Gary B. Kaplan, MD Anthony Liguori, PhD Edythe London, PhD Athina Markou, PhD S. Michael Owens, PhD Linda J. Porrino, PhD Andrew J. Saxon, MD Sandra Welch, PhD

Saturday, June 18, 2005

PRE-MEETING SATELLITES

The International Study Group Investigating Crown Hall Drugs as Reinforcers (ISGIDAR) Chaired by Michael A. Nader

5 th Annual Meeting Center for Substance Abuse Treatment (CSAT) Great Hall East Science to Services and Services to Science: The Identification and Adoption of Effective Practices for Substance Abuse Treatment Chaired by Karl D. White

The 10th Annual NIDA International Forum on England Building International Research on Drug Abuse: Progress through Collaboration Chaired by Steven Gust

Translating Basic Research from Neural, Behavioral, Ireland and Social Sciences to Prevention: Challenges and Opportunities

Food, Drugs, Obesity and Addiction: Common Scotland C Neurobiologic Processes? Chaired by Nora D. Volkow and Joseph Frascella

CPDD REGISTRATION Great Hall Assembly

Saturday, June 18 1:30 PM - 5:30 PM

Sunday, June 19 8:00 AM - 12:00 PM 2:00 PM - 5:30 PM

Monday, June 20 8:00 AM - 1:00 PM 2:00 PM - 5:00 PM

Tuesday, June 21 8:00 AM - 1:00 PM

Wednesday, June 22 8:00 AM - 12:30 PM 2:00 PM - 5:00 PM

Thursday, June 23 7:30 AM - 1:00 PM

OPENING RECEPTION 7:00 – 9:00 PM (Cash Bar) Pool Area

xii Sunday, June 19, 2005

Sunday, June 19, 2005

CSAT TRAVEL AWARDEES BREAKFAST Grosvenor Resort (By Invitation Only) 7:00 - 8:30 AM

Plenary Session Great Hall 8:30 - 11:00 AM 8:30 Welcome Warren K. Bickel, President, CPDD 8:45 Report from the National Institute on Drug Abuse Nora D. Volkow, Director, NIDA 9:15 Presentation of the Meritorious Service Award to Ian P. Stolerman Introduction by Chris-Ellyn Johanson, 9:20 Presentation of the Media Award to Brian Vastag Introduction by Marc J. Kaufman, 9:25 Presentation of the Joseph Cochin Young Investigator Award to Thomas E. Eissenberg Introduction by Robert L. Balster, 9:30 Presentation of the Joseph Cochin Young Investigator Award to James K. Rowlett Introduction by William L. Woolverton, 9:35 Presentation of the Mentorship Award to Linda A. Dykstra Introduction by Alison Oliveto-Beaudoin, 9:40 Presentation of the Nathan B. Eddy Award to Conan Kornetsky Introduction by George F. Koob, 9:45 Nathan B. Eddy Award Lecture A walk through the history of drug abuse: Research, trends and fads Conan Kornetsky, Boston University School of Medicine, Boston, MA

President’s Lecture Great Hall 1:00 - 2:00 PM COGNITIVE SEQUELAE OF DRUG ABUSE: STUDIES IN HUMANS AND EXPERIMENTAL ANIMALS

Trevor Robbins University of Cambridge, UK

1 Sunday, June 19, 2005

Symposium I Scotland 2:00 - 4:00 PM DRUGS OF ABUSE AND REGULATORS OF G-PROTEIN SIGNALING

Chairs: John Traynor and Richard Neubig 2:00 Just what are RGS proteins? David Siderovski, The University of North Carolina at Chapel Hill, Chapel Hill, NC 2:25 RGS protein modulation of abuse liability properties of and John Traynor, University of Michigan Medical School, Ann Arbor, MI 2:50 Regulation of RGS proteins by drugs of abuse Stephen Gold, UT Southwestern Medical Center at Dallas, Dallas, TX 3:15 Inhibitors of RGS protein activity Richard Neubig, University of Michigan Medical School, Ann Arbor, MI 3:40 RGS proteins as targets for drug abuse treatment medications Discussant: Richard B. Rothman, NIH/NIDA Intramural Research Program, Baltimore, MD

Symposium II England 2:00 - 4:00 PM DEPENDENCE AND PSYCHIATRIC DISORDERS: TREATMENT IMPLICATIONS

Chairs: Ivan D. Montoya and Himanshu P. Upadhyaya 2:00 Biological determinants of in severe mental disorders: Cognitive deficits and genetic polymorphisms as targets for therapeutics development Tony P. George, Yale University, Connecticut Mental Health Center, New Haven, CT 2:25 Treatment of nicotine dependence in individuals with schizophrenia Douglas M. Ziedonis, Robert Wood Johnson Medical School, Piscataway, NJ 2:50 Treatment of comorbid ADHD and nicotine dependence Himanshu P. Upadhyaya, Medical University of South Carolina, Charleston, SC 3:15 Current research and future directions for treating nicotine dependence among illicit drug users Kimber P. Richter, University of Kansas Medical Center, Kansas City, KS 3:40 Discussant Lirio S. Convey, Columbia University and New York State Psychiatric Institute, New York, NY

2 Sunday, June 19, 2005

Oral Communications I Crown Hall 2:00 - 4:00 PM MDMA: IS IT REALLY ECSTASY?

Chairs: Richard A. Glennon and Chris-Ellyn Johanson 2:00 Pizotyline fully antagonizes the discriminative stimulus effects of MDMA R.A. Glennon and R. Young, Virginia Commonwealth University, Richmond, VA 2:15 Consequences of exposure to neurotoxic regimens of and MDMA (ecstasy) on cognitive paradigms in mice C. Achat-Mendes, S.F. Ali and Y. Itzhak, University of Miami School of Medicine, FL and NCTR, FDA, Jefferson, AR 2:30 3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) elicits context-dependent locomotor and electrophysiological sensitization in freely moving rats K.T. Ball, D. Budreau and G.V. Rebec, Indiana University, Bloomington, IN 2:45 Tolerance to behavioral and neuroendocrine effects of ecstasy (MDMA) in rats M.H. Baumann, F.H. Franken, J.J. Rutter, R.D. Clark and R.B. Rothman, NIH/NIDA Intramural Research Program, Baltimore, MD 3:00 Effects of ecstasy (MDMA) on plasma in rats: In vivo and in vitro evaluation D. Zolkowska, M.H. Baumann, R.D. Clark and R.B. Rothman, NIH/NIDA Intramural Research Program, Baltimore, MD 3:15 MDMA-induced hyperthermia in rhesus monkeys M.A. Taffe, S.N. Katner, C.C. Lay, S.N. Von Huben, R.D. Crean, S.A. Davis and A.J. Kirsten, The Scripps Research Institute, La Jolla, CA 3:30 The effects of MDMA on sleep architecture and subsequent mood in humans C.E. Johanson, T. Roehrs and M. Tancer, Wayne State University, Detroit, MI and Henry Ford Hospital, Detroit, MI 3:45 Striatal release during a motorbike riding computer game in novelty seekers and recreational ecstasy users in SPECT A.M. Weinstein, M. Greemland, H. Lerman, I. Herman, S. Schreiber, R. Bar-Hamburger and E. Even-Sapir, Sourasky Medical Center, Tel Aviv, Jaffa Treatment Center for Drug Victims, Israel and Israeli-Anti Drug Authority, Jerusalem, Israel Oral Communications II Ireland 2:00 - 3:00 PM MISUSED PRESCRIPTION DRUGS: CRUELLA DE PILL

Chairs: James A. Inciardi and Curtis Wright 2:00 Trends in the diversion of prescription opioids in the United States J.A. Inciardi, A. Hernandez, J.L. Goode and Y. Lugo, University of Delaware, Center for Drug and Studies, Coral Gables, FL 2:15 Characteristics of nonmedical users of : Results from the National Survey on Drug Use and Health J.D. Haddox, M.Y. Smith and C. Wright IV, Purdue Pharma L.P., Stamford, CT

3 Sunday, June 19, 2005

2:30 Characterizing controlled-release abuse in a Canadian treatment facility B.A. Sproule, B. Brands and L. Catz-Biro, University of Toronto, Toronto, Canada 2:45 Antecedents of prescription abuse in the CARDIA study M.J. Pletcher, S. Kertesz, S. Sidney, C.I. Kiefe and S.B. Hulley, University of California, San Francisco, CA, University of Alabama at Birmingham, AL and Kaiser Permanente Division of Research, Oakland, CA Oral Communications III Ireland 3:30 - 4:30 PM POLICY IN THE CLINIC AND COURTROOM

Chairs: Cynthia L. Arfken and Jennifer P. Wisdom 3:30 Who provides specialized programs for criminal justice populations? C.L. Arfken, S.P. Kubiak, A. Koch and J. Roddy, Wayne State University, Detroit, MI 3:45 Substance-use patterns in drug court: No problem? D.S. DeMatteo, D.S. Festinger, P.A. Lee and D.B. Marlowe, Treatment Research Institute, Philadelphia, PA 4:00 Towards an agreement about evaluation instruments in health care units on drug abuse in the autonomous region of Valencia (Spain) C. Morales, A. Vidal, M. Castellano, P. De Vicente, J.C. Perez de los Cobos, R. Aleixandre, S. Tortajada and J.C. Valderrama, Instituto de Historia de la Ciencia y Documentación Lopez Piñero (UV-CSIC), FEPAD, Generalitat Valenciana and Hospital de la Santa Creu i Sant Pau, Valencia, Spain 4:15 Process improvement to increase access and retention: Real-world application in a women- focused substance abuse treatment agency J.P. Wisdom, E. Gifford, and N. Roget, Oregon Health and Science University, Portland, OR and Center for Health Care Evaluation, VA Palo Alto Health Care System, Palo Alto, and Stanford University School of Medicine, Stanford, CA Symposium III England 4:45 - 5:45 PM TREATMENT OF THE PREGNANT ADDICT: FROM THE LABORATORY TO THE CLINIC

Chairs: Mahmoud S. Ahmed and Amrat Patel 4:45 Effects of a nicotine vaccine on nicotine transfer to the fetus in rats: A model of pharmacokinetic approaches at reducing fetal exposure to addictive drugs Paul Pentel, Hennepin County Medical Center, Minneapolis, MN 5:05 Noninvasive assessment of fetal brain activity Curtis L. Lowery, University of Arkansas for Medical Sciences, Little Rock, AR 5:25 The role of human placental enzymes and transporters in regulating the extent of fetal exposure to opioids Discussant: Mahmoud S. Ahmed, University of Texas Medical Branch, Galveston, TX

4 Sunday, June 19, 2005

Oral Communications IV Scotland 4:45 - 5:45 PM CAPTAIN HOOKED: CHRONIC IN ANIMALS

Chairs: Mei-Chuan Ko and Sandra P. Welch 4:45 Differential in vivo potencies of and 6beta-naltrexol in primates M.C. Ko, M.F. Divin, H. Lee, J.R. Traynor and J.H. Woods, University of Michigan Medical School, Ann Arbor, MI and Ewha Women’s University, Seoul, Korea 5:00 Development of sensitization in C57BL/6 mice is inhibited by intra-ventral tegmental administration of a that targets PDZ domain of PSD-95 G.B. Kaplan, K.A. Leite-Morris, A.K. O’Neill, M.A. Klufas, M.R. Spaller and J. Marshall, Brown Medical School, Brown University, VA Medical Center, Providence, RI and Wayne State University, Detroit, MI 5:15 Clorgyline, , and L-methamphetamine modify morphine-seeking and morphine- reinforced behaviors: Insights towards selegiline’s mechanism of action K.W. Grasing and S. He, Department of Veterans Affairs Medical Center, Kansas City, MO and University of Kansas Medical Center, Kansas City, KS 5:30 Compensatory changes in KIR6.2 potassium channel subunit protein and SUR binding in the expression and re-expression of tolerance to morphine S.P. Welch and V.L. Haller, Virginia Commonwealth University, Richmond, VA

Oral Communications V Ireland 4:45 - 5:45 PM SIGNALING: "CRACKING" THE CODE

Chairs: Wendy J. Lynch and Bertha K. Madras 4:45 CART knockout mice respond differently to cocaine and novelty than wild-type controls M.C. Moffett, H.M. Hsiung, M.A. Asnicar and M.J. Kuhar, Yerkes National Primate Center, Emory University, Atlanta, GA and Eli Lily & Co., Indianapolis, IN 5:00 Sex differences in the molecular consequences of ‘binge’ cocaine self-administration in rats W.J. Lynch and J.R. Taylor, Yale University School of Medicine, New Haven, CT 5:15 Cystine-glutamate transport in the dopamine neurochemistry of cocaine in squirrel monkeys M. Sen, R.M. Bauzo, H.L. Kimmel and L.L. Howell, Emory University, Yerkes National Primate Research Center, Atlanta, GA 5:30 New roles for an old trace amine and monoamine transporters B.K. Madras, C.D. Verrico, A.K. Jassen and G.M. Miller, Harvard Medical School, New England Regional Primate Research Center, Southborough, MA

5 Sunday, June 19, 2005

Oral Communications VI Crown Hall 4:45 - 5:45 PM HEPATITIS C

Chairs: Steven L. Batki and Gabriele Fischer 4:45 Hepatitis C treatment in injection drug users: The NIH consensus conference process B.R. Edlin, Cornell University Medical College, New York, NY 5:00 Characteristics of opioid-dependent patients seeking hepatitis C treatment S.L. Batki, K. Canfield, R. Levine, S. Lundell, L. Donohue and K. Amodio, SUNY Upstate Medical University and VA Center for Integrated Healthcare - VA Healthcare Network Upstate New York, Syracuse, NY 5:15 Eligibility for treatment of hepatitis C virus (HCV) infection among injection drug users (IDUs) in a multisite study H. Hagan, M. Latka, J. Campbell, E.T. Colub, R.S. Garfein, D.A. Thomas, F. Kapadia and S.A. Strathdee, NDRI, Inc., New York Academy of Medicine, New York, NY, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 5:30 Treatment of hepatitis C/subtype 2 or 3 with pegylated interferon in combination with ribavirin in a population of opioid-dependent patients A. Baewert, N. Ebner, K. Thau and G. Fischer, Medical University of Vienna, Austria Pre & Postdoc Mixer Cloister 6:00 - 7:30 PM

Workshop I Great Hall 8:00 - 10:00 PM NIDA WORKSHOP AND POSTER SESSION ON INTERNATIONAL RESEARCH AND COLLABORATION

Chairs: Steven Gust and Patricia Needle

Workshop II Scotland 8:00 - 10:00 PM STATISTICAL METHODS IN DRUG DEPENDENCE RESEARCH

Chairs: James C. Anthony and Howard Chilcoat Overview and introduction James C. Anthony, Michigan State University, East Lansing, MI A strategy for optimizing and evaluating behavioral interventions: Concepts, principles, and methods Linda M. Collins, Penn State University, University Park, PA Individually tailored and adaptive interventions: Issues for methodologists Susan A. Murphy, University of Michigan, Ann Arbor, MI 6 Sunday, June 19, 2005

Modeling drug-taking behavior in rats: Mixed models in application Stephanie T. Lanza, Penn State University, State College, PA Discussion and closing remarks Howard D. Chilcoat and James C. Anthony, Johns Hopkins University, Baltimore, MD and Michigan State University, East Lansing, MI Workshop III Ireland 8:00 - 10:00 PM DIFFUSION RESEARCH IN THE NIDA CLINICAL TRIALS NETWORK

Chairs: James L. Sorensen and Betty Tai Adoption of motivational interviewing following a CTN clinical trial Joseph Guydish, University of California, San Francisco, CA Organizational process in treatment programs Cynthia Arfken, Wayne State University, Detroit, MI CTN membership and adoption of innovative treatment practices Paul Roman, University of Georgia, Athens, GA Disseminating the results of CTN studies: Bi-directional processes John Hamilton, LMG Programs, Inc., Stamford, CT Diffusion of empirically derived interventions: An agenda for research James L. Sorensen, University of California, San Francisco, CA Discussant Jack B. Stein, NIDA, Bethesda, MD Workshop IV Crown Hall 8:00 - 10:00 PM THE BITTEREST PILL: MEDICATION NON-COMPLIANCE

Chairs: Joy M. Schmitz and Marc E. Mooney Use of electronic monitoring to improve adherence to prescribed medications among drug-using patients Marc I. Rosen, Yale University School of Medicine, West Haven, CT Interventions to increase use of nicotine gum: A randomized, controlled, single-blind trial Marc E. Mooney, University of Texas Medical School, Houston, TX Contingent reinforcement of medication compliance in a clinical trial of Levodopa/Carbidopa for cocaine dependence Joy M. Schmitz, University of Texas Medical School, Houston, TX Medication non-adherence in determining efficacy of pharmacotherapy in Helen M. Pettinati, University of Pennsylvania School of Medicine, Philadelphia, PA Discussant John Grabowski, University of Texas Medical School, Houston, TX

7 Monday, June 20, 2005

Monday, June 20, 2005

POSTER SESSION I (Breakfast) Exhibition Hall 8:00 - 10:00 AM Odd-numbered posters manned first hour; Even-numbered, second hour

Set-up time begins Sunday 1:00 PM Must be removed by Monday 12:30 PM SEX DIFFERENCES AND DRUGS OF ABUSE - HUMAN STUDIES 1 Parent gender moderates relations between parent psychopathology, parenting, and child psychopathology in substance-abusing families M. Burstein, C. Stanger, and J. Kamon, University of Vermont, South Burlington, VT 2 Types of child maltreatment that affect stress-coping in cocaine-dependent men and women S.M. Hyman, M. Garcia and R. Sinha, Yale University School of Medicine, New Haven, CT 3 Gender-specific effects in the effects of child maltreatment on cocaine relapse outcomes P. Paliwal, S.M. Hyman and R. Sinha, Yale University School of Medicine, New Haven, CT 4 Childhood physical and sexual abuse as risk factors for substance dependence S.E. Afful, J.R. Kleinheider, L.B. Cottler and L.J. Bierut, Washington University School of Medicine, St. Louis, MO 5 The influence of family support on drug-use trajectories of minority female addicts R.E. Brisgone, Rutgers University School of Criminal Justice, Newark, NJ 6 Female-sensitive drug treatment: Evidence of enhancements in a women-only versus a mixed- gender therapeutic community M.P. Huey, J.A. Johnson and P.M. Roman, University of Georgia, Athens, GA 7 Assessing sex differences on treatment effectiveness from the drug abuse treatment outcome study S. Acharyya and H. Zhang, Brown University, Providence, RI and Yale University, New Haven, CT 8 Offender substance abuse treatment for women: An evaluation of gender differences B.R. Garner, K. Knight, D.D. Simpson and P.M. Flynn, Texas Christian University and Institute of Behavioral Research, Fort Worth, TX 9 Spiritual activities and previous spiritual experience as predictors of treatment outcome among patients in an inner city maintenance program A.J. Heinz, D.H. Epstein and K.L. Preston, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 10 Improving the transition from residential to outpatient addiction treatment: Gender differences in response to supportive telephone calls L.F. Haynes, S.E. Back, J. Leimberger and R. Hubbard, Medical University of South Carolina, Charleston, SC and Duke University, Durham, NC 11 Gender differences in the effects of stimulants on sexual experiences C.P. Domier, A. Brown and R. Rawson, University of California, Los Angeles, CA 12 Influence of menstrual cycle phase on illicit drug use B.J. Walton-Moss and M.E. McCaul, Johns Hopkins University, Baltimore, MD

8 Monday, June 20, 2005

13 Nicotine pretreatment increases dysphoric effects of alcohol in luteal-phase female volunteers D. Penetar, E. Kouri, M. Gross, E. McCarthy, E. Peters and S.E. Lukas, McLean Hospital, Harvard Medical School, Belmont, MA 14 The influence of sex on the expression of beta2-nicotinic receptors using [123I]5-I- A-85380 SPECT K.P. Cosgrove, E.B. Frohlich, M.A. Terlecki, E. Perry, R.M. Baldwin, G.D. Tamagnan, J.P. Seibyl, S. O’Malley, C.M. Mazure and J.K. Staley, Yale University, New Haven, VA Medical Center, West Haven, Institute for Neurodegenerative Disorders, New Haven, CT and Vanderbilt University, Nashville, TN 15 Gender difference in the prevalence and the severity of white matter hyperintensities in methamphetamine users S.C. Bae, I.K. Lyoo, Y.H. Sung, S.J. Bae, A. Chung, J. Hwang, M.Y. Sim, J. and P.F. Renshaw, Seoul National University College of Medicine and Hospital, Seoul, Korea and McLean Hospital Brain Imaging Center, Belmont, MA 16 Correlation between neuropsychological deficits and indices of vascular resistance to flow in cocaine abusers: Gender differences N.M. Wilson, K. Tate, W. Better, K. Bolla, R. Herning and J.L. Cadet, NIH/NIDA Intramural Research Program and Johns Hopkins School of Medicine, Baltimore, MD 17 Gender differences in medical and non-medical use of opioids, sedatives and stimulants among -dependent research volunteers C.L. Steinmiller and M.K. Greenwald, Wayne State University, Detroit, MI 18 Sex differences in analgesic and subjective responses to morphine in humans W.J. Kowalczyk, S.D. Comer and S.M. Evans, New York State Psychiatric Institute, Columbia University and Queens College, New York, NY 19 , a mu , decreases behavioral sensitization in female rats treated with estrogen A.C. Segarra, J.M. Soto, M.A. Fernandez and J.M. Orenstein, University of Puerto Rico, School of Medicine, San Juan, PR IMAGING - HUMAN AND ANIMAL STUDIES 20 Men, women, money and beauty: Gender differences in the brain-processing of rewarding stimuli B.B. Frederick, S. Dunlap, D. Ariely, D. Penetar, N. Mazar, S.E. Lukas and I. Elman, McLean Hospital, Belmont, Harvard Medical School, Boston, and MIT, Cambridge, MA 21 Magnetic resonance studies of unanesthetized squirrel monkeys at 3T C. Zuo, M. Delatte, M. Rohan, B. Frederick, M. Gasior, M. Brimson, M. Zielstorff, E. Jensen, P.F. Renshaw, J. Bergman and M.J. Kaufman, McLean Hospital, Belmont, MA 22 Effects of social and monetary stimuli on the reward circuitry activation in patients with Post Traumatic Stress Disorder I. Elman, B. Frederick, D. Ariely, S. Dunlap, J. Rodolico, D. Penetar, N. Mazar, J. Cohan, R. Pitman and S. Lukas, McLean Hospital, Harvard Medical School, Belmont, MIT, Cambridge, and Massachusetts General Hospital, Harvard Medical School, Boston, MA 23 A 3.0 T BOLD fMRI study of word encoding in human MDMA users R.L. Cowan, H. Liang, S. Park, C. Cannistraci, J.C. Gatenby, S.E. Lukas, P.F. Renshaw, J.C. Gore and R. Shelton, Vanderbilt University Medical Center, Nashville, TN, McLean Hospital, Belmont, and Harvard Medical School, Boston, MA 24 Extinction-based cessation treatment attenuates event-related brain responses to smoking cues F.J. McClernon, J.E. Rose, F.B. Hiott, J. Liu, Duke University Medical Center, Durham, NC 9 Monday, June 20, 2005

25 Interest of the FibroScan in the screening of cirrhosis in alcoholism consultation P. Melin, L. Gourarier, A. Dacon, A. Gauchet, M. Schoeny and M.D. Diebold, Saint Dizier Hospital, Saint Dizier, Metz University, Metz, Reims Hospital, Reims, and HEGP, Paris, France 26 Brain imaging study of orientation, coordination and executive function in recreational users of marijuana O. Brickner, A.M. Weinstein, H. Lerman, M. Bloch, R. Mechoulam, R. Bar-Hamburger and E. Even-Sapir, Sourasky Medical Center, Tel Aviv, Hadassah Hospital, Jerusalem, and Israeli Anti-Drug Authority, Jerusalem, Israel 27 DTI measures correlate with cognitive performance in heavy cannabis smokers P.J. Pimentel, D.E. Murray, D.A. Yurgelun-Todd and S.A. Gruber, McLean Hospital, Harvard Medical School, Belmont, MA 28 Changes in BOLD fMRI response during finger tapping in chronic cannabis smokers following 28 days of discontinuation S.S. Pillay, J. Rogowska, H.G. Pope, S.A. Gruber and D.A. Yurgelun-Todd, McLean Hospital, Harvard Medical School, Belmont, MA 29 EEG profile of chronic marijuana abusers during monitored abstinence K. Tate, W. Better, R.I. Herning and J.L. Cadet, NIH/NIDA Intramural Research Program, Baltimore, MD 30 Impact of ASPD diatheses on the EEG profiles of chronic cocaine and marijuana abusers J.L. Cadet, W. Better, K. Tate and R.I. Herning, NIH/NIDA Intramural Research Program, Baltimore, MD 31 withdrawal increases cerebral blood flow velocity and alters quantitative electroencephalography activity S.C. Sigmon, A.L. Chausmer, W. Better, R.I. Hernin and R.R. Griffiths, Johns Hopkins University School of Medicine, and NIDA, Baltimore, MD 32 Shape changes of amygdala in cocaine abusers I.K. Lyoo, A. Chung, S.J. Kim, Y.H. Sung, S.C. Bae, J.S. Oh, C. Streeter and P.F. Renshaw, Seoul National University Hospital, Seoul, Korea, Boston University Medical Center, Boston, and McLean Hospital Brain Imaging Center, Belmont, MA 33 Focal amygdalar activation by 500 millisecond drug cues in cocaine patients: An event-related functional magnetic resonance imaging study A.R. Childress, R.N. Ehrman, J. Listerud, N. Sciortino, R. Willhite, K. Marquez, J.G. Hakun, J. Vietri and C.P. O’Brien, University of Pennsylvania School of Medicine, Philadelphia, PA 34 Chronic cocaine self-administration increases magnetic resonance transverse relaxation (T2) times in rhesus monkey caudate nucleus M.J. Kaufman, J.B. Daunais, T.L. Barros, J. Eskesen, R. Kraft, M. Rohan, M.A. Nader, P.F. Renshaw and L.J. Porrino, McLean Hospital, Harvard Medical School, Belmont, MA and Wake Forest University School of Medicine, Winston-Salem, NC 35 [11C], a highly selective ligand for the , accumulates in the human posterior-inferior cerebellar vermis in vivo C.M. Anderson, T. Spencer, P.F. Renshaw, M.J. Kaufman and B.K. Madras, McLean Hospital, Belmont, Massachusetts General Hospital, Boston, Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 36 PET imaging studies of monkey dopamine D2 receptors and transporters during self- administration of cocaine under different access conditions and during abstinence P.W. Czoty, B.A. Reboussin, S.H. Nader, T. Moore, M. Bounds, H.D. Gage and M.A. Nader, Wake Forest University School of Medicine, Winston-Salem, NC

10 Monday, June 20, 2005

37 Imaging brain mu-opioid receptor binding during behavioral treatment of cocaine dependence M.L. Copersino, D.H. Epstein, K.L. Preston, S.J. Boyd, J.J. Frost, Y.K. Kim, R.F. Dannals, I.A. Alhamrawy and D.A. Gorelick, NIH/NIDA Intramural Research Program and Johns Hopkins University School of Medicine, Baltimore, MD 38 Comparison of regional cerebral blood flow between short-term abstinent methamphetamine users and long-term abstinent methamphetamine users M.Y. Sim, I.K. Lyoo, J. Hwang, S.J. Kim, Y.H. Sung, S.C. Bae, J. Kim and P.F. Renshaw, Seoul National University College of Medicine and Hospital, Seoul, Korea and McLean Hospital Brain Imaging Center, Belmont, MA 39 Gender difference in size and integrity of the fronto-striatal white matter tract in abstinent methamphetamine users: Diffusion tensor imaging and tractograpy study A. Chung, I.K. Lyoo, S.J. Kim, J.S. Oh, S.C. Bae, S.J. Bae, M.Y. Sim, J. Hwang and P.F. Renshaw, Seoul National University College of Medicine and Hospital, Seoul, Korea and McLean Hospital Brain Imaging Center, Belmont, MA METHAMPHETAMINE, - ANIMAL STUDIES 40 Implication of Neuronal Wiskott-Aldrich Syndrome Protein in the methamphetamine-induced dopamine release T. Tanaka, M. Narita and T. Suzuki, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan 41 Dopamine- and serotonin-mediated effects of psychostimulants are differentially modulated by the nitrergic (nitric oxide) system Y. Itzhak, K.L. Anderson and S.F. Ali, University of Miami School of Medicine, Miami, FL and NCTR, FDA, Jefferson, AR 42 Discriminative-stimulus effects of psychostimulants during chronic D2 agonist treatment in methamphetamine-trained monkeys J. Bergman, McLean Hospital, Harvard Medical School, Belmont, MA 43 Degree of methamphetamine (MA)-induced stereotypy does not predict MA reward A.L. Atkins and J.K. Belknap, Boston University, Boston, MA and Oregon Health Sciences University, Portland, OR 44 Long-term neurotoxicity after chronic high-dose methamphetamine E.H. Ellinwood, X. Zhang, Q. Chen, T.H. Lee and C. Davidson, Duke University Medical Center, Durham, NC 45 Deprenyl attenuates dopamine and glutamate changes after a chronic methamphetamine regimen C. Davidson, Q. Chen, X. Zhang, T.H. Lee and E.H. Ellinwood, Duke University Medical Center, Durham, NC 46 Sigma-1 receptors regulate hippocampal dendritic spine morphogenesis and the localization of NMDA and AMPA receptors S.Y. Tsai, T. Hayashi and T.P. Su, NIH/NIDA Intramural Research Program, Baltimore, MD 47 CNS myelination controlled by sigma-1 receptors at cholesterol/galactosylceremide-enriched lipid microdomains in oligodendrocyte progenitors T. Hayashi and T.P. Su, NIH/NIDA Intramural Research Program, Baltimore, MD 48 Effect of amphetamine on transcript and protein levels of CREB-family transcription factors in rat striatum T.A. Green, I.N. Alibhai and E.J. Nestler, University of Texas Southwestern Medical Center, Dallas, TX

11 Monday, June 20, 2005

49 Role of D1 receptors for amphetamine-induced behavioral sensitization and conditioned activity: A study using D1 receptor knockout mice C.M. Reichel, M.C. Cyr, P.E. Karper, A. Nazarian, C.A. Crawford and S.A. McDougall, California State University, San Bernardino, CA and University of North Carolina School of Medicine, Chapel Hill, NC 50 Role of the central nucleus of the amygdala in enrichment-induced changes of rat amphetamine self-administration M.E. Cain, D.J. Stairs, R.W. Brown and M.T. Bardo, Kansas State University, Manhattan, KS, University of Kentucky, , KY and East Tennessee State, Memphis, TN 51 Extinction and reinstatement of amphetamine self-administration and sucrose-maintained responding in differentially reared rats D.J. Stairs, E.D. Klein and M.T. Bardo, University of Kentucky, Lexington, KY

STRESS 52 Maternal separation alters sucrose consumption in both offspring and dam months later C.C. Michaels and S.G. Holtzman, Emory University School of Medicine, Atlanta, GA 53 Effects of early life stress on sensitivity to stimulants in rhesus monkeys S.B. Ewing, M.M. Sanchez, L.A. Neidert, A.C. Murnane and L.L. Howell, Yerkes National Primate Research Center, Emory University, Atlanta, GA 54 Cocaine and stress reactivity: Subjective and physiological gender differences S.E. Back, K.T. Brady, J.L. Jackson, S. Salstrom and H. Zinzow, Medical University of South Carolina, Charleston, SC and University of Georgia, Athens, GA 55 Stress-related fMRI brain activity predicts cocaine relapse outcomes R. Sinha, C. Lacadie, C.S.R. Li, P. Skudlarski and T.R. Kosten, Yale University School of Medicine, New Haven, CT 56 Stress and cue reactivity in cocaine dependence: Methodological considerations A.E. Waldrop, K.T. Brady, A.L. McRae, M. Saladin, L. Santa Ana, H. Upadhyaya, A. Sensenig and U. Jaanimägi, Medical University of South Carolina, Charleston, SC 57 Responses to Trier Social Stress Test in single vs. grouped subjects L.M. Vicini, E.C. Childs and H. de Wit, University of Chicago, Chicago, IL 58 Gender differences in responses to stress and drug-cues in cocaine-dependent individuals H.C. Fox, M. Garcia, G. Anderson, R.M. Malison, M.J. Kreek and R. Sinha, Yale University School of Medicine, New Haven, CT and The Rockefeller University, New York, NY OPIOIDS - ANIMAL STUDIES 59 Effect of handling on hormonal modulation of nociception and opioid antinociception R.M. Craft and C.M. Ulibarri, Washington State University, Pullman, WA 60 Time course of the modulatory effects of gonadal hormones on nociception, morphine antinociception, and reproductive indices in rats J.E. Sumner and R.M. Craft, Washington State University, Pullman, WA 61 Influence of ultra-low doses of naltrexone on the acute enhancement of morphine antinociception and attenuation of tolerance in male and female rats of four strains J.M. Terner, L.M. Lomas, A.C. Barrett, S.S. Negus and M.J. Picker, University of North Carolina at Chapel Hill, NC and McLean Hospital, Harvard Medical School, Belmont, MA 62 Role of spinal metabotropic glutamate receptor 5 in the development of tolerance to morphine- induced antinociception in mice M. Suzuki, M. Narita, M. Miyatake, T. Aoki, M. Asato, M. Narita and T. Suzuki, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan 12 Monday, June 20, 2005

63 Periadolescent morphine exposure alters subsequent behavioral sensitivity to morphine in adult rats D.A. White and S.G. Holtzman, Emory University School of Medicine, Atlanta, GA 64 Heroin-induced sensitization of locomotor activity observed in a study of conditioned place preference in C57BL/6J mice N.M. Dankert, S.D. Schlussman, Y. Zhang, A. Ho and M.J. Kreek, The Rockefeller University, New York, NY 65 Opposite effects of acetylcholine enhancement in VTA and NAc on drug seeking elicited by cues after abstinence in a model of relapse to heroin in rats W. Zhou, F. Zhang, S. Tang, M. Lai and H. Zhu, Ningbo Addiction Research and Treatment Center, Ningbo, China 66 CTAP evokes partial generalization to discriminative stimulus effects of morphine in pigeons trained in a three-key morphine discrimination M. Evola and A.M. Young, Texas Tech University Health Sciences Center, Lubbock, TX 67 Neonatal maternal separation significantly affects expression of mu opioid receptor mRNA in the thalamus of adult rats S.D. Schlussman, D.A. White, L.E. Bence, A.C. Harmon, A. Ho, S.G. Holtzman and M.J. Kreek, The Rockefeller University, New York, NY and Emory University, Atlanta, GA 68 Chronic exercise decreases sensitivity to mu opioids in female rats: Correlation with exercise output M.A. Smith and M.A. Lyle, Davidson College, Davidson, NC 69 Precipitated withdrawal from acute morphine dependence in the rat and odor aversion A.C. Harmon, D.A. White, and S.G. Holtzman, Emory University School of Medicine, Atlanta, GA 70 Depressive-like behavior associated with precipitated and spontaneous fentanyl withdrawal in rats A.W. Bruijnzeel, B. Lewis, L.K. Bajpai, D.M. Dennis, T.E. Morey and M.S. Gold, College of Medicine, University of Florida, Gainesville, FL 71 Injection speed does not affect the reinforcing effect of i.v. morphine in the rat runway G. Zernig, J.A. Crespo, G. Wakonigg, K. Sturm and A. Saria, Innsbruck Medical University, Innsbruck, Austria 72 Role of glial cells in the development of methamphetamine- and morphine-induced rewarding effects M. Narita, M. Miyatake, M. Shibasaki, K. Shindo, A. Nakamura, M. Narita and T. Suzuki, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan 73 Effect of treatment with psychostimulants, opioids or on neural differentiation from neural stem cell of mice N. Kuzumaki, M. Narita, M. Narita and T. Suzuki, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan 74 Chronic morphine upregulates Ga12 and cytoskeletal proteins in CHO cells expressing the cloned mu opioid receptor and also in mouse brain R.B. Rothman, X. Wang, D. Zimmerman, E.S. Boja, J. Wang, E.J. Bilsky and H. Xu, NIH/NIDA Intramural Research Program, Baltimore, MD 75 Pharmacological investigations of and derivatives K.J. Tidgewell, R.A. Moyer, L.M. Bohn, W.W. Harding, C.M. Dersch, R.B. Rothman and T.E. Prisinzano, The University of Iowa, Iowa City, IA, NIH/NIDA Intramural Research Program, Baltimore, MD and Ohio State University, Columbus, OH

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76 Synthesis and functional analysis of rigid 6-(3-hydroxyphenyl)-3-azabicyclo[3.1.0]hexanes as kappa opioid antagonists S.P. Runyon, H. Navarro and F.I. Carroll, Research Triangle Institute, Research Triangle Park, NC 77 Trimethylsilyl-diazomethane as a methylating agent in the synthesis of -6-methyl ether C.W. Cunningham, L.N. Thatcher and A. Coop, University of Maryland, Baltimore, MD 78 Stereoselective oxime reduction – a versatile tool for the synthesis of selective opioid ligands A.P. Neal, J.W. Lewis, J.R. Traynor and S.M. Husbands, University of Bath, Bath, UK and University of Michigan, Ann Arbor, MI 79 Methods for microinfusion/microdialysis studies of in vivo biotransformation of opioid in the dorsolateral striatum of the rat B. Reed, N.M. Dankert, B.E. Oosterhuis, B.T. Chait and M.J. Kreek, The Rockefeller University, New York, NY DRUG INTERACTIONS - ANIMAL STUDIES 80 The selective N-methyl-D-aspartate , LY235959, attenuates the expression of morphine-conditioned place preference in C57Bl6 mice J.D. Lane, K.A. Carrigan and L.A. Dykstra, University of North Carolina at Chapel Hill, Chapel Hill, NC 81 Interactive effects of a N-methyl-D-aspartate receptor antagonist in combination with low-efficacy mu- in C57BL/6 mice B.D. Fischer and L.A. Dykstra, University of North Carolina at Chapel Hill, Chapel Hill, NC 82 Functional changes in receptor and system following chronic midazolam treatment in mice K. Nanjo, M. Narita, M. Negishi and T. Suzuki, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan 83 Alcohol does not potentiate the aversiveness of cocaine within the conditioned taste aversion design G.D. Busse, A. Verendeev, J. Jones and A.L. Riley, Medical University of South Carolina, Charleston, SC and American University, Washington, DC 84 Effects of low doses of CP-154,526 and ketoconazole on cocaine self-administration in rats A.M. Burrows, G.F. Guerin and N.E. Goeders, Louisiana State University Health Science Center, Shreveport, LA 85 Discriminative stimulus effects of intravenous cocaine and heroin in rhesus monkeys: Mu and delta opioid receptor mechanisms D.M. Platt, J.K. Rowlett and R.D. Spealman, Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 86 Ethanol modulates the discriminative stimulus effects of methamphetamine: Mechanisms R. Pratt, M.J. Forster and M.B. Gatch, University of North Texas Health Science Center, Fort Worth, TX ADOLESCENTS: POLYDRUG ABUSE 87 Prevalence and pattern of drug use in high school students in Jalisco State, Mexico C. Alvarez-Gonzalez, O. Campollo, H. Sanchez and J. Toro-Guerrero, University of Guadalajara and Antiguo Hospital Civil de Guadalajara, México 88 Religion and negative environment as predictors of American Indian adolescent substance abuse/dependence symptoms M. Yu, A. Stiffman and L. Cottler, Washington University School of Medicine, St. Louis, MO

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90 Gender and ethnic differences across drug-abuse and sexual-risk behaviors among African American and Hispanic adolescents referred for drug abuse treatment F.R. Dillon, M.S. Robbins, J. Szapocznik, C.W. Turner and H.B. Waldron, University of Miami School of Medicine, Miami, FL and Oregon Research Institute, Eugene, OR 91 Adolescent drug opportunities, use, and use by peers: Does gender matter? A.L. Stone, H.D. Chilcoat and N. Ialongo, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 92 A multivariate at drug dealing among multi-problem female youths in the US, CY2003 J. Ode, C.F. Ríos-Bedoya and J.C. Anthony, Michigan State University, East Lansing, MI and Johns Hopkins University, Baltimore, MD 93 From marijuana to cocaine initiation: A time-to-event analysis using a multi-cohort approach W.E. Maalouf, R. Shih and H.D. Chilcoat, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 94 Developing and pilot feasibility testing a multi-problem screening system for youth L.S. Hess, S. Libretto, M. Landry, N. Linder and E. Moolchan, Danya International Inc., Silver Spring, MD and NIH/NIDA Intramural Research Program, Baltimore, MD 95 Children of fathers with substance use disorders: Are they different from other children? N. Peleg-Oren, G. Rahav and M. Teichman, Florida International University, Miami, FL and Tel-Aviv University, Tel-Aviv, Israel 96 Maternal maltreatment, substance abuse, and child’s dysregulation A.C. Mezzich, M. Swaney and B.S. Day, University of Pittsburgh, Pittsburgh, PA 97 Understanding health-related needs and risks among impoverished young women in the transition to adulthood: Violence, substance use, STDs, mental health S. Wenzel, E. D’Amico, M. Ellison, J. Tucker, and K. Hambarsoomian, RAND, Santa Monica, CA 98 Childhood neurobehavior disinhibition and deviant activities of friends predict distorted perception of risky behavior and identify youth at high risk for SUD L. Kirisci, R. Tarter, M. Vanyukov, M. Reynolds and M. Habeych, University of Pittsburgh, Pittsburgh, PA 99 An analysis of risk domains associated with the number of drugs used by active Latino gang members M. DeLaRosa, C. Rice and D. Rugh, Florida International University, Miami, FL 100 Early age of first sexual behavior predicts development of SUD: A prospective study J.R. Cornelius, D.B. Clark, M. Reynolds, L. Kirisci and R. Tarter, University of Pittsburgh, Pittsburgh, PA 101 Alcohol, marijuana and adolescent sexual behavior L.J. Floyd, W. Latimer and B. Mancha, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 102 Measuring mechanisms of behavior change in adolescent drug treatment A. Marcum, B. Cage and W.W. Latimer, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 103 The Bridge Adolescent Residential Treatment Program outcomes: Effects of client characteristics and time in treatment R.D. Ketterlinus, S. Rothstein, L. Hurtig and J. Benitez, Philadelphia Health Management Corporation, Philadelphia, PA

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104 Referral sources and access to adolescent treatment for SUD: Results from the National Treatment Center Study C.L. Dempsey, P.D. Riggs, H.K. Knudsen and P.M. Roman, University of Colorado School of Medicine, Denver, CO and University of Georgia, Athens, GA 105 Engagement and retention of adolescents in continuing care following residential treatment M. Fishman, L. Payne, J. Gooch and P. Clemmey, Johns Hopkins University, Baltimore, MD 106 Outcome of CRA with homeless adolescents: Preliminary findings N. Slesnick, J.L. Prestopnik and R.J. Meyers, Ohio State University, Columbus, OH and University of New Mexico, Albuquerque, NM 107 Randomized controlled trial of fluoxetine/placebo and cognitive behavioral treatments in depressed adolescents with substance use disorders P.D. Riggs, M. Lohman, R. Davies, S. Mikulich-Gilbertson, M. Laudenslager, C. Klein, M. Chapman, A. Libby, S. Hall, H. Orton, C. Thurstone and S. Brown, University of Colorado School of Medicine, Denver, CO 108 Assessing ADHD in substance-dependent adolescents L.L. Thompson, S. Young, S.K. Mikulich-Gilbertson and T.J. Crowley, University of Colorado School Medicine, Denver, and University of Colorado, Boulder, CO CLUB DRUGS AND HALLUCINOGENS - HUMAN STUDIES 109 Risk of hallucinogen dependence soon after onset of use: United States, 2002-2003 A. de la Torre, C.F. Ríos-Bedoya, A.L. Stone and J.C. Anthony, Michigan State University, East Lansing, MI and Johns Hopkins University, Baltimore, MD 110 Distinctions between MDMA and hallucinogen abuse and dependence diagnoses and criteria S.L. McCrary, M.S. Fague, L.C. Cottler, J.A. Inciardi and J. Copeland, Washington University School of Medicine, St. Louis, MO, University of Delaware, Coral Gables, FL and University of New South Wales, St. Ives, 111 Incident cases of ecstasy use in the United States, 2003 G. Mazzotti and J.C. Anthony, UPCH, Lima, Peru, Johns Hopkins University, Baltimore, MD and Michigan State University, East Lansing, MI 112 Economic predictors of ecstasy consumption and related problems in a general community sample A. Ben Abdallah, L.M. Scheier, J.A. Inciardi, J. Copeland and L.B. Cottler, Washington University, St. Louis, MO, LARS Research Institute, Las Vegas, NV, University of Delaware, Coral Gables, FL and National Drug and Alcohol Research Center, , Australia 113 Contextual influences on ecstasy use among young, low-income women: Effects of neighborhood and personal networks Z.H. Wu, K. Eschbach, J.J. Grady and A.B. Berenson, The University of Texas Medical Branch, Galveston, TX 114 Perceptions of harm among MDMA users by DSM abuse and dependence status N.A. Camal, S.L. McCrary, M.S. Fague and L.B. Cottler, Washington University School of Medicine, St. Louis, MO 115 Three-site study of prescription drug abuse among ecstasy users S.P. Kurtz, H.L. Surratt, J.A. Inciardi, L. Cottler and J. Copeland, University of Delaware, Coral Gables, FL, Washington University, St. Louis, MO and University of New South Wales, Sydney, Australia 116 The sexual risk behaviors of ecstasy users in Miami, Florida J.L. Goode, Y. Lugo and S.P. Kurtz, University of Delaware, Coral Gables, FL

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117 Abuse liability of gamma-hydroxybutyrate (GHB, sodium oxybate) in humans: A pilot study M. Farré, S. Abanades, F. Fonseca, O. Sánchez, E. Menoyo, S. Pichini, M. Segura and R. de la Torre, Universitat Autònoma, Universitat Pompeu Fabra, Barcelona, Spain, and Istituto Superiore Sanità, Rome, Italy 118 Offshore investigations of the non-addictive plant : 1996 to 2004 D.C. Mash, L. Duque, J.D. Kamlet, F.D. Ervin and K. Allen-Ferdinand, University of Miami School of Medicine, Miami, FL, McGill University, Montreal, Canada and Healing Visions, St. Kitts, WI 119 Structured elicitation narrative reveals a variety of ibogaine experiences L. Duque, C. Foord, B. Page and D.C. Mash, University of Miami School of Medicine, Miami, FL PSYCHIATRIC COMORBIDITY I 120 Drug abuse in mental illness assessed through the association between drug abuse patterns and psychiatric inventories H. Nyborg and H. Albeck, University of Aarhus, Denmark 121 Alcohol, drug and mental health comorbidity on the Texas-Mexico border L.S. Wallisch and R.T. Spence, University of Texas, Austin, TX 122 Disturbed sleep, mental health problems, and substance abuse among women with victimization experiences R. Walker, L. Shannon and T.K. Logan, University of Kentucky, Lexington, KY 123 Concurrent and predictive validity of drug use and psychiatric disorders among first-time DWI offenders R.S. Palmer, S.A. Ball, B.J. Rounsaville and S.S. O’Malley, Yale University School of Medicine, New Haven, CT 124 Potential advantages of offering medication and psychosocial services in drug abuse treatment settings for patients with psychiatric comorbidity: Early findings V.L. King, K.J. Neufeld, G. Gallucci, K.B. Stoller, J. Peirce and R.K. Brooner, Johns Hopkins University School of Medicine, Baltimore, MD 125 Medication adherence in co-occurring disorders M.V. Pantalon, R.S. Schottenfeld, J.A. Cramer, K.M. Carroll and B.J. Rounsaville, Yale University School of Medicine, New Haven, CT 126 Co-occurring services in a methadone-maintained population R. Bilangi and T. Kosten, Connecticut Counseling Centers, Inc., Middlebury, CT 127 The effect of individual, program, and community variables on continuity of treatment among dually diagnosed individuals S. Mazzella, G. Stahler, S. Chakravorty, G. Rengert, J. Mennis and R. Spiga, Temple University, Philadelphia, PA 128 Treatment of co-occurring disorders: Dissemination efforts with challenges A.H. Skinstad, P.E. Nathan and A.B. Wallis, The University of Iowa, Iowa City, IA 129 Characteristics of substance abuse treatment completion of clients with co-occurring psychiatric and substance use disorders L.F. Mangrum and R.T. Spence, University of Texas, Austin, TX 130 Assessing substance use among patients with schizophrenia J.E. Strong Kinnaman, M.E. Bennett and A.S. Bellack, University of Maryland School of Medicine, Baltimore, MD

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131 The relationship between lifetime abuse and suicidal ideation in a sample of injecting drug users J.J. Lloyd, E.P. Ricketts, C.L. Latkin, L.J. Cornelius, D. Bishai, S. Huettner, J.R. Havens and S.A. Strathdee, University of Maryland School of Social Work, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, University of Kentucky College of Medicine, Lexington, KY and University of California School of Medicine, La Jolla, CA 132 Recovery from substance use disorder in patients with bipolar disorder: Does it matter? R.D. Weiss, M. Ostacher, M.W. Otto, R.E. Bender, J.R. Calabrese, M. Fossey, S.R. Wisniewski, C. Bowden, A.A. Nierenberg, M.H. Pollack, I. Salloum, N.M. Simon, M.E. Thase, G.S. Sachs, Harvard/McLean Hosp., MA General Hosp., MA, Case U. School Medicine, U. Hosp. Cleveland, OH, U. Oklahoma, Tulsa, OK and U. Pittsburgh, PA 133 The impact of treatment for heroin dependence on current major depression: 12-month findings from Treatment Outcome Study A. Havard, M. Teesson, J. Ross and S. Darke, University of New South Wales, Sydney, Australia 134 Influence of major depressive disorder on the pharmacokinetic-pharmacodynamic relationships of methadone A.K. Elkader, B.A. Sproule, P. Selby and B. Brands, University of Toronto, Canada 135 Probing the brain reward system in comorbid major depressive disorder and X.L. Balducci, C.A. Naranjo, N. Herrmann and U.E. Busto, Sunnybrook & Women’s College, Toronto, Canada 136 Response to acute tryptophan depletion in alcoholics and depressed alcoholics V. Sanci, A.Y. Chu, C.A. Naranjo, N. Herrmann and U.E. Busto, Sunnybrook & Women’s College, Toronto, Canada 137 Psychiatric comorbidity in ecstasy users: A three-year follow-up controlled study M. Torrens, R. Martin-Santos, J.M. Ginés, S. Poudevida, M. Farré and R. de la Torre, Drug Abuse Unit-IAPS-Hospital del Mar, Universitat Autónoma Barcelona, and Universitat Pompeu Fabra, Barcelona, Spain 138 Depression and associated health problems among ecstasy users Y. Lugo, J.L. Goode and S.P. Kurtz, University of Delaware, Coral Gables, FL 139 Role of baseline predictors, patient participation, and outcome in cognitive-behavioral therapy with depressed cocaine users: A meditational model A.C. Brooks, J. Nevid, E. Aharonovich and E.V. Nunes, Columbia University, New York, New York State Psychiatric Institute, New York, and St. John’s University, Queens, NY 140 for the treatment of depressed cocaine abusers W.N. Raby, E. Masson, F. Garawi, A. Bisaga, F.R. Levin, E. Rubin, D. McDowell and E.V. Nunes, Columbia University, New York, NY THEORETICAL/COMMENTARY 141 A low-cost olfactometer for delivering odors in cue-related studies S.B. Lowen and S.E. Lukas, McLean Hospital, Belmont, and Harvard Medical School, Boston, MA 142 Neuropsychological impairment of drug abusers: Commentary A.M. Horton, Jr., Psych Associates, Towson, MD 143 Correction of fMRI perfusion artifact in a study of drug craving in cocaine patients J. Listerud, A.R. Childress, J. Detre, J.J. Wang and C. O’Brien, University of Pennsylvania and Hospital of the University of Pennsylvania, Philadelphia, PA

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144 A Markov transition model for longitudinal count data with nonignorable missing values J. Li, X. Yang, Y. Wu and S. Shoptaw, BayesSoft, Inc., and University of California, Los Angeles, CA 145 MPI -- a statistical software package for analyzing longitudinal data with missing values X. Yang, G. Liu, T. Belin, Q. Zhang and S. Shoptaw, BayesSoft, Inc., and University of California, Los Angeles, CA 146 Strategies for analyzing behaviors in textual data from semi-structured interviews D. Rugh and M. DeLaRosa, Florida International University, Miami, FL 147 A novel methodology for “anonymous” clinical trials: Better data and better participant protection without certificates of confidentiality? L.A. Strathdee, J.R. Beatty, D. Moore and S.J. Ondersma, Wayne State University, Detroit, MI 148 Differential completion rates across three cocaine treatment studies K.R. Cochran, S.L. Hedden, S. Shoptaw and R.J. Malcolm, Medical University of South Carolina, Charleston, SC and University of California, Los Angeles, CA 149 Randomization strategies in a three-arm clinical trial: Methodological comparisons and an application in the modafinil trial for cocaine dependence S.L. Hedden, R.F. Woolson, R.J. Malcolm and K.T. Brady, Medical University of South Carolina, Charleston, SC 150 Oral cocaine as agonist therapy in cocaine dependence T. Llosa and L. Llosa, COCADI, Lima, Peru, and Miami, FL 151 Motivational factors in addiction recovery: A qualitative theory K.J. Speck and A.H. Skinstad, Doane College, Lincoln, NE and University of Iowa, Iowa City, IA 152 Early findings - Colorado Women’s Prison Project: Comparing substance abuse (SA) behaviors, behavioral histories, service needs/utilization of 2 age cohorts with SA problems M.L. Schoeneberger and J.Y. Sacks, NDRI-CIRP, New York, NY 153 Fentanyl use and abuse: New emerging trends in drug abuse B.A. Goldberger, M.I. Fileger, M.L. Merves and M.S. Gold, University of Florida, College of Medicine, Gainesville, FL 154 Drug policy reform in Georgia D.O. Otiashvili and I.P. Pkhovelishvili, Union “Alternative Georgia”, and Georgian Research Institute on Addiction, Tbilisi, Georgia 155 A comprehensive approach to evidence-based strategic illicit drug policy A. Ritter, M. Hamilton, G. Bammer, L. Mazerolle and P. Dietze, Turning Point Alcohol and Drug Centre, Fitzroy, University of , St. Albans, Australian National University, Canberra, and Griffith University, Brisbane, Queensland, Australia 156 Key aspects for the management of HIV-positive drug users in Latin America M. Malta, F.I. , M. Monteiro and S.A. Strathdee, Johns Hopkins School of Public Health, Baltimore, MD, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Pan American Health Organization and University of California School of Medicine, Los Angeles, CA 157 How do state drug policies address pain and addiction? M.A. Maurer, A.M. Gilson and D.E. Joranson, University of Wisconsin Comprehensive Cancer Center, Madison, WI

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President’s Lecture Great Hall 10:00 - 11:00 AM COMPUTATIONAL MODELING INTEGRATES STRUCTURE-BASED MECHANISMS OF GPCRs INTO CELL PATHWAY SIGNALING BY DRUGS OF ABUSE

Harel Weinstein Weill Medical College of Cornell University

Symposium IV Scotland 11:00 AM - 1:00 PM PROTEOMICS AND ITS APPLICATION TO DRUG ABUSE RESEARCH

Chair: Christine Colvis 11:00 Application of proteomic technologies to neuroproteomics research Christopher M. Colangelo, Yale NIDA Proteomics Center, New Haven, CT 11:25 Using proteomics to characterize “Your brain on drugs” Ariel Deutch, Vanderbilt University School of Medicine, Nashville, TN 11:50 Proteomics of hepatitis C: Model systems and biopsies Deborah L. Diamond, University of Washington, Seattle, WA 12:15 Membrane proteomics: Advances, applications, and challenges that remain Christine Wu, University of Colorado School of Medicine, Aurora, CO 12:40 Discussant Christine Colvis, NIDA, Bethesda, MD Oral Communications VII England 11:00 AM - 1:00 PM COCAINE AND BEHAVIOR: SNOW WHITE MEETS BF SKINNER

Chairs: Kelly A. Carrigan and James K. Rowlett 11:00 Cocaine self-administration in rats with histories of cocaine exposure and discrimination E.L. Childs, M. Shoaib and I.P. Stolerman, The University of Chicago, Chicago, IL, and King’s College London, London, UK 11:15 Deletion of the NR1 subunit of the N-methyl-D-aspartate glutamate receptor disrupts cocaine-conditioned place preference K.A. Carrigan and L.A. Dykstra, University of North Carolina at Chapel Hill, Chapel Hill, NC 11:30 The role of group II metabotropic glutamate receptors in cocaine self-administration and cocaine-priming-induced drug-seeking behavior A.S. Adewale and R.D. Spealman, Harvard Medical School, NERPRC, Southborough, MA

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11:45 Attenuation of cocaine self-administration by the mGluR5 antagonist MPEP: Comparison with the NMDA antagonist dizocipline J.K. Rowlett, D.M. Platt and R.D. Spealman, Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 12:00 Sensitization to the reinforcing effects of self-administered cocaine: Influence of speed of injection D. Morgan, D.C.S. Roberts and Y. Liu, Wake Forest University School of Medicine, Winston-Salem, NC 12:15 Effects of mGluR5 antagonists on cocaine discrimination and self-administration in rats R.J. Ralph, M.C. Gale, D. Allagille, G. Tamagnan, R.M. Baldwin and S.B. Caine, McLean Hospital/Harvard Medical School, Belmont, MA, Yale University, New Haven, CT and Vanderbilt University, Nashville, TN 12:30 Strain differences in concurrently cocaine-conditioned aversions and preferences: C57BL/6J, 129/SvJ and C57 x 129 mice J.F. Randall-Thompson, F.S. Hall, G.R. Uhl and A.L. Riley, American University, Washington, DC and NIH/NIDA Intramural Research Program, Baltimore, MD 12:45 Calcineurin A-beta-deficient mice display augmented cocaine-induced locomotor sensitization but are less sensitive to the rewarding effects of cocaine L.C. Tang, A. Clifford, O.F. Bueno, A.A. Robertson and J.R. Mantsch, Marquette University, Milwaukee, WI and Cincinnati Children's Hospital Medical Center, Cincinnati, OH Oral Communications VIII Ireland 11:00 AM - 1:00 PM AIDS/HIV

Chairs: Marc Auriacombe and Lisa A. Marsch 11:00 Spatial analysis of drug purchase and use locations among injection drug users in Philadelphia: Potential role in HIV prevention J.R. Kraut-Becher, K. Lynch, D. Fiore and D.S. Metzger, University of Pennsylvania, Philadelphia, PA 11:15 Change in i.v. sharing behavior and condom use among admissions to opiate dependence treatment over a 10-year period (1994-2003) M. Auriacombe, R. Poutet, E. Lavie, C. Denis, M. Fatséas and J. Daulouède, Université Victor Segalen Bordeaux, and BIZIA, Bayonne, France 11:30 Reductions in HCV and HIV infection among injecting drug users in New York City, 1990-2001 D.C. Des Jarlais, T. Perlis, K. Arasteh, L.V. Torian, H. Hagan, S. Beatrice, L. Smith, J. Wethers, J. Milliken, S. Yancovitz and S.R. Friedman, Beth Israel Medical Center, NDRI, Inc., New York State Department of Mental Hygiene, and New York State Department of Health, New York, NY 11:45 Computer-delivered HIV and other disease prevention for substance-abusing youth L.A. Marsch, W.K. Bickel, H. Guarino and A. Desrosiers, NDRI, New York, NY, HealthSim, Inc., Burlington, VT and University of Arkansas for Medical Sciences, Little Rock, AR 12:00 HIV prevention can be effectively integrated into routine methadone treatment for IDUs I. Lee and M. Copenhaver, University of Connecticut, Storrs, CT

21 Monday, June 20, 2005

12:15 HIV and drug use in Kenya: Assessing HIV and substance abuse treatment services L. Sullivan, D. Fiellin, B. Levine, M. Chawarski and R. Schottenfeld, Yale University School of Medicine, New Haven, CT 12:30 Interaction with and HIV therapeutics P. Pade, J.R. Baker, C. Exhem-Williams, L. Hellew, P.M. Rainey, D.E. Moody and E.F. McCance-Katz, Virginia Commonwealth University, Richmond, VA, University of Washington, Seattle, WA and University of Utah, Salt Lake City, UT 12:45 Cocaine use interferes with HIV antiretroviral medication adherence: Stage 1 formative research J. Cohen, C.J. Heckman, M.Q. Lewis and K.S. Ingersoll, Virginia Commonwealth University, Richmond, VA Oral Communications IX Crown Hall 11:00 AM - 1:00 PM EFFECTS OF ALCOHOL AND NOVEL TREATMENTS

Chairs: Elise M. Weerts and Keith L. Williams 11:00 Development of naltrexone supersensitivity during food-reinforced responding enhances naltrexone’s ability to reduce ethanol-reinforced responding K.L. Williams, Grand Valley State University, Allendale, MI 11:15 Alcohol drinking in baboons: Effects of 3-propyloxy-beta-carboline E.M. Weerts, B.J. Kaminski, W. Yin, P.V.V.S. Sarma and J.M. Cook, Johns Hopkins University School of Medicine, Baltimore, MD and University of Wisconsin-Milwaukee, Milwaukee, WI 11:30 Acute interaction of in combination with alcohol in moderate/heavy drinkers S.M. Evans and A. Bisaga, New York State Psychiatric Institute and Columbia University, New York, NY 11:45 Alcohol effects in a cumulative dosing paradigm during treatment in heavy drinkers K.L. Foster and E. Houtsmuller, Johns Hopkins University, Baltimore, MD 12:00 The use of trileptal (Oxcarbazepine) in alcohol detoxification and treatment L.L. Hanselka, I. Gromov, A. Bondora and H.C. Urschel III, Matrix Alliance Recovery Systems, Dallas, TX 12:15 Effects of Δ9–THC on cognitive-motor skills (driving), physiological state, and subjective feelings compared to the effects of 0.05% blood alcohol concentration A. Ronen, R. Gertner, P. Gershon, H. Drobiner, R. Bar-Hamburger, R. Mechoulam, Y. Cassuto and D. Shinar, Ben-Gurion University of the Negev, Beer-Sheva, Hebrew University, and Anti-drug Authority of Israel, Jerusalem, Israel 12:30 Alcohol use to intoxication predicts poorer treatment outcomes in methadone-stabilized pregnant women M. Tuten and H.E. Jones, Johns Hopkins University School of Medicine, Baltimore, MD 12:45 STEPS outpatient program demonstrates efficacy in reducing alcohol use in Ukraine N. Vlasova, J. Schumacher, K. Dumchev and Y. Kim, STEPS Center, Vinnitsya, Ukraine, and The University of Alabama at Birmingham, Birmingham, AL

22 Monday, June 20, 2005

EARLY CAREER INVESTIGATOR Outback Restaurant AWARDS LUNCHEON (By Invitation Only) 1:00 - 2:30 PM

Oral Communications X Crown Hall 2:30 - 4:30 PM DRUGS AND THE HPA AXIS: STRESS TESTS

Chairs: John R. Mantsch and Lisa M. Schrott 2:30 Gender differences of the stress responsive hormones: Prolactin, ACTH, and cortisol in normal and former cocaine-dependent volunteers H.L. Hofflich, Y. Gurevich, G. Bart, A. Ho and M.J. Kreek, The Rockefeller University, New York, NY 2:45 The effects of cigarette smoking on mood states and the HPA axis during menstrual cycle phase J.H. Mendelson, M.B. Sholar, N.V. Goletiani, A.J. Siegel and N.K. Mello, McLean Hospital, Belmont, and Harvard Medical School, Boston, MA 3:00 Reduced salivary cortisol after overnight deprivation N.C. Eid, M. al’Absi, E.T. Moolchan, S. Boyd and W.B. Pickworth, NIH/NIDA Intramural Research Program, Baltimore, MD and University of Minnesota, Duluth, MN 3:15 The role of the stress axis in adolescent drug-taking N.L. Schramm-Sapyta, Q.D. Walker, M.P. Brooks, J.M. Caster and C.M. Kuhn, Duke University Medical Center, Durham, NC 3:30 Increased sensitivity in D3 dopamine receptor-deficient mice to stress-responsive hypothalamic POMC gene expression and HPA activity by acute binge cocaine J.C. Choi, Y. Zhou, A. Ho, J. Zhang, M. Xu and M.J. Kreek, The Rockefeller University, New York, NY and University of Cincinnati, Cincinnati, OH 3:45 The escalation of cocaine self-administration by chronic footshock stress in rats is context- dependent and requires stressor-induced glucocorticoid secretion J.R. Mantsch, M.J. Anderson, B.D. Porter, M. Sajan and E.S. Katz, Marquette University, Milwaukee, WI 4:00 Increased response to metyrapone at trough methadone levels S.M. Stine, D.Y. Tansil and C.R. Schuster, Wayne State University, Detroit, MI 4:15 The hypothalamic-pituitary-adrenal axis is activated during postnatal withdrawal from prenatal opiate exposure L.M. Schrott and L.M. Franklin, Louisiana State University Health Sciences Center, Shreveport, LA

23 Monday, June 20, 2005

Oral Communications XI Ireland 2:30 - 4:30 PM NICOTINE: MECHANISMS OF ACTION

Chairs: Adam Bisaga and Kenneth A. Perkins 2:30 Discriminative stimulus and subjective effects of nicotine following alcohol or caffeine pre-load K.A. Perkins, C. Fonte, R. Blakesley-Ball, A. Stolinski and A.S. Wilson, University of Pittsburgh, Pittsburgh, PA 2:45 Acute smoking abstinence and reinstatement on biochemical and psychological indices of smoking in schizophrenics and controls: Effects of nicotinic receptor antagonism A.H. Weinberger, K.A. Sacco, A. Termine, T.M. Allen, E. Reutenauer, J.C. Vessicchio, P.I. Jatlow and T.P. George, Yale University School of Medicine, New Haven, CT 3:00 Nicotine cues activate brain areas rich in nicotinic receptors and those involved in reward in female smokers using a modified Iowa Gambling Task K.G. Drexler, A. Alford, K. Harenski, F. Sheahan, E. Duncan, S. Hamann, D.B. Neill and C. Kilts, Atlanta VA Medical Center, Decatur, and Emory University, Atlanta, GA 3:15 The effect of cigarette prime in the laboratory model of relapse in cigarette smokers A. Bisaga, M. Padilla, F. Garawi and M. Haney, New York State Psychiatric Institute and Columbia University, New York, NY 3:30 Region-specific transcriptional response to chronic nicotine treatment in C3H mouse J. Wang, Y. Hwang, R. Gutala, J.Z. Ma and M.D. Li, University of Texas Health Science Center, San Antonio, TX 3:45 Perinatal nicotine exposure modifies nicotine-stimulated rubidium efflux across adolescence in the rat A.F. Britton, R.E. Vann and S.E. Robinson, Virginia Commonwealth University, Richmond, VA 4:00 Nicotine increases dopamine transporter function and cell surface expression in rat prefrontal cortex R.C. Bruntz, J. Zhu, S. Apparsundaram and L.P. Dwoskin, University of Kentucky, Lexington, KY 4:15 Monoclonal nicotine-specific antibodies reduce nicotine distribution to brain in rats: Dose-and affinity-response relationships D.E. Keyler, S.A. Roiko, H. Benlhabib, M.G. LeSage, J. St. Peter, S. Stewart, S. Fuller, C.T. Le and P.R. Pentel, Minneapolis Medical Research Foundation, University of Minnesota Medical School and Nabi Biopharmaceuticals, Minneapolis, MN

BADGES MUST BE WORN IN ALL SCIENTIFIC SESSIONS

24 Monday, June 20, 2005

Symposium V England 2:30 - 3:30 PM THE DATA ON DATA: EVALUATING THE IMPACT OF BUPRENORPHINE’S INTRODUCTION IN THE MEDICAL COMMUNITY

Chairs: Eric C. Strain and H. Westley Clark 2:30 Results from SAMHSA/CSAT’s national evaluation of the buprenorphine waiver program Arlene Stanton, Substance Abuse and Mental Health Services Administration, Rockville, MD 2:50 Results from the Wayne State University post-marketing assessment of buprenorphine Charles R. Schuster, Wayne State University, Detroit, MI 3:10 The DEA’s perspective on the evaluation and post-marketing assessments of buprenorphine Denise Curry, Office of Division Control, Drug Enforcement Administration, Arlington, VA Symposium VI Scotland 2:30 - 3:30 PM MOUSE TALES: USING MOLECULAR GENETICS TO UNDERSTAND ADDICTION

Chair: Jonathan Pollock 2:30 Results of a screen to identify modulate monoaminergic signaling Andrew Peterson, University of California San Francisco, Emeryville, CA 2:50 Using mice to understand nicotine and cocaine addiction Marina Picciotto, Yale University School of Medicine, New Haven, CT 3:10 Using a multipronged genetics approach to understand addiction Marc Caron, Duke University, Durham, NC Symposium VII England 4:00 - 5:00 PM HARM REDUCTION AND ADDICTIONS TREATMENT: CONTEMPORARY PERSPECTIVES, CONTEMPORARY VISIONS

Chair: George E. Woody 4:00 Harm reduction psychotherapy: A new treatment for drug and alcohol problems Andrew Tatarsky, Harm Reduction Psychotherapy and Training Associates, New York, NY 4:20 Harm reduction, drug policy, and the importance of the social contract Robert DuPont, Institute for Behavior and Health, Inc., Rockville, MD 4:40 Discussant Scott Kellogg, The Rockefeller University, New York, NY

25 Monday, June 20, 2005

Symposium VIII Scotland 4:00 - 5:00 PM KAPPA OPIOID RECEPTORS AND DRUG ABUSE: CHEMISTRY, PHARMACOLOGY, AND BEHAVIOR

Chair: Thomas Prisinzano 4:00 A novel kappa , JDTIC, selectively blocks stress-induced relapse to cocaine- directed behavior Patrick Beardsley, Virginia Commonwealth University Medical Center, Richmond, VA 4:20 Probing mechanisms modulating stress and addictive behaviors with kappa opioid receptor antagonists Jay McLaughlin, Northwestern University, Boston, MA 4:40 Kappa opioid receptor ligands: Selective agonists and antagonists Discussant: Thomas Prisinzano, University of Iowa, Iowa City, IA

Marian W. Fischman Great Hall Memorial Award Lecture 5:00 - 6:00 PM Presentation of the Marian W. Fischman Memorial Award to Mary Jeanne Kreek Introduction by Warren K. Bickel

Marian W. Fischman Memorial Award Lecture Mary Jeanne Kreek, The Rockefeller University

Training Grant Mixer Cloister 6:30 - 8:00 PM

Workshop V Ireland 8:00 - 10:00 PM WHAT’S NEW AT NIDA AND NIH: HOW WILL IT AFFECT YOU?

Chairs: Mark R. Green, Teri Levitin, and Mark Swieter

26 Monday, June 20, 2005

Workshop VI England 8:00 - 10:00 PM POTENTIAL TECHNOLOGIES AND STRATEGIES FOR THE DEVELOPMENT OF ABUSE-RESISTANT ANALGESICS

Chair: William K. Schmidt Introduction Willam K. Schmidt, Renovis, Inc., South San Francisco, CA If it were easy, it would have been done by now! A retrospective assessment of commercial, government and academic efforts to develop opioid analgesics with reduced abuse liability Charles Grudzinskas, NDA Partners, LLC, Annapolis, MD Concepts and development of next-generation abuse-resistant oxycodone CR formulations Robert D. Colucci, Purdue Pharma L.P., Stamford, CT Development of abuse-resistant opioids in an entrepreneurial environment Ron J. Spivey, Acura Pharmaceuticals, Inc., Culver, IN Regulatory and post-marketing perspectives: Validation of clinical efficacy and development of risk management programs for abuse-resistant medications Nathaniel Katz, Inflexxion, Inc., Newton, MA Concepts and development of IX-1003 (intranasal buprenorphine) Michael Perkins, Ionix Pharmaceuticals, Cambridge, UK Workshop VII Crown Hall 8:00 - 10:00 PM NEW RESEARCH ON SELF-HELP AND RECOVERY FROM SUBSTANCE ABUSE

Chair: Stephen Magura The role of 12-step fellowships, social supports, spirituality and stress in quality of life among individuals in long-term recovery from substance abuse Alexandre Laudet, National Development and Research Institutes, New York, NY Long-term patterns and benefits of self-help: 10-year follow-up of the project MATCH Albuquerque sample J. Scott Tonigan, University of New Mexico, Albuquerque, NM The effects of dual-focus 12-step fellowship affiliation on recovery: A two-year longitudinal study Stephen Magura, National Development and Research Institutes, New York, NY Discussant William L. White, Lighthouse Institute, Chestnut Health Systems, Bloomington, IL

27 Monday, June 20, 2005

Workshop VIII Scotland 8:00 - 10:00 PM SOCIETY FOR ADOLESCENT SUBSTANCE ABUSE TREATMENT EFFECTIVENESS (SASATE) 4TH ANNUAL MEETING

Chairs: Michael L. Dennis and Frank M. Tims The interaction of adolescent substance use severity, violence and crime in predicting the response to treatment and recidivism over 30 months Michael L. Dennis, Chestnut Health Systems, Bloomington, IL Predictors of the onset of anti-social and borderline personality disorder between presenting for substance abuse treatment as an adolescent and turning into a young adult (+18) Frank M. Tims, University of South Florida, Petersburg, FL The interaction of gender with patterns of crime/violence and subsequent adolescent treatment outcomes over 30 months Patricia A. Shane, Alta Bates Summit Medical Center, Oakland, CA SASATE Business Meeting Michael L. Dennis, Chestnut Health Systems, Bloomington, IL

Tuesday, June 21, 2005

POSTER SESSION II (Breakfast) Exhibition Hall 8:00 - 10:00 AM Odd-numbered posters manned first hour; Even-numbered, second hour

Set-up time begins Monday 1:00 PM Must be removed by Tuesday 12:30 PM CLUB DRUGS - ANIMAL STUDIES 1 Ethers of hydroxyphenyl acetic acids as GHB ligands H. Wu, W. Chen, R.J. Hernandez, A.K. Meht, M.K. Ticku, C.P. France and A. Coop, University of Maryland, Baltimore, MD and University of Texas Health Science Center at San Antonio, San Antonio, TX 2 Discriminative stimulus effects of GHB and flumazenil: Asymmetric substitution W. Koek, L.P. Carter, W. Chen, H. Wu, A. Coop and C.P. France, University of Texas Health Science Center, San Antonio, TX and University of Maryland, Baltimore, MD 3 Comparison of the behavioral effects of gammabutyrolactone and gamma-hydroxybutyrate in baboons A.K. Goodwin and E.M. Weerts, Johns Hopkins University School of Medicine, Baltimore, MD

28 Tuesday, June 21, 2005

4 Effects of 3,4-methylenedioxymethamphetamine on autonomic and behavioral thermoregulation R.J. Irvine, E.J. Jaehne and A. Salem, University of Adelaide, Australia 5 Effects of elevated ambient temperature on -induced hyperthermia in monkeys M.L. Banks, P.W. Czoty and M.A. Nader, Wake Forest University Health Sciences, Winston-Salem, NC 6 MDMA administration does not decrease levels of the protein or alter its distribution between endosomes and the plasma membrane X. Wang, M.H. Baumann, H. Xu and R.B. Rothman, NIH/NIDA Intramural Research Program, Baltimore, MD 7 The 5-HT1A receptor and the stimulus effects of LSD C.J. Reissig, J.C. Winter, J.R. Eckler and R.A. Rabin, State University of New York at Buffalo, Buffalo, NY 8 Delay discounting for in rhesus monkeys J.L. Perry and M.E. Carroll, University of Minnesota, Minneapolis, MN SEX DIFFERENCES AND DRUGS OF ABUSE - ANIMAL STUDIES 9 Sex differences in behavioral sensitization to cocaine A. Nazarian, L.M. Kemen, H.B.K. Wu, T. Niyomchai and V. Quinones-Jenab, Hunter College/City University of New York, New York, NY 10 Genetic strain, maternal environment, and biological sex interact to affect cocaine-induced taste aversions in Fischer and Lewis rats C.M. Davis, P.G. Roma, M.A. Keeler and A.L. Riley, American University, Washington, DC 11 Chronic estradiol administration mediates the inflammatory response to formalin in OVX female rats T. Kuba, L.M. Kemen and V. Quinones-Jenab, Hunter College and City University of New York, New York, NY 12 Effects of testosterone on cocaine-induced conditioned place preference: SILASTIC capsule implants vs. acute administration A.C.E. Minerly, S.J. Russo, L.M. Kemen, A. Nazarian, H.B.K. Wu, K.M. Weierstall, A. Akhavan, S. Jenab and V. Quinones-Jenab, Hunter College and City University of New York, New York, NY 13 Effects of short- vs. long-term estrogen treatment on cocaine-induced reinstatement in OVX female rats E.B. Larson, M.E. Roth, J.J. Anker and M.E. Carroll, University of Minnesota, Minneapolis, MN 14 Effects of and estrogen antagonists on cocaine-induced behavioral psychomotor responses H.B.K. Wu, T. Niyomchai, K. Weierstall, A.C.E. Minerly, D. Hunter, J. Weiner, W. Sun, L. Zhou, S. Jenab and V. Quinones-Jenab, Hunter College and City University of New York, New York, NY 15 The role of 5-HT1A and 5-HT1B in cocaine-induced locomotor activity in male and female rats K.M. Weierstall, T. Niyomchai, H.B.K. Wu, A. Akhavan, J. Weiner, W. Sun, A. Nazarian, S. Jenab and V. Quinones, Hunter College and City University of New York, New York, NY 16 Acute effects of testosterone and progesterone on cocaine self-administration by female rhesus monkeys N.K. Mello, J.H. Mendelson, I.M. Knudson and M. Kelly, McLean Hospital, Belmont, and Harvard Medical School, Boston, MA 29 Tuesday, June 21, 2005

17 Ovarian hormones modulate levels of dopamine and turnover rates after acute cocaine administration T. Niyomchai, S.J. Russo, E.D. Festa and V. Quinones-Jenab, City University of New York and Hunter College, New York, NY 18 Prenatal cocaine exposure alters the monoamine system in a gender-specific manner: Adrenergic receptors and transporter J.M. Silvers, M. Ferris, U. Hasselrot, B.J. Strupp, C.F. Mactutus and R.M. Booze, University of South Carolina, Columbia, SC and Cornell University, Ithaca, NY 19 Prenatal cocaine exposure alters the monoamine system in a gender-specific manner: Dopamine D1 receptors M.J. Ferris, J.M. Silvers, B.J. Strupp, C.F. Mactutus and R.M. Booze, University of South Carolina, Columbia, SC and Cornell University, Ithaca, NY 20 Acute and repeated intravenous cocaine-induced locomotor activity is altered as a function of sex and gonadectomy S.B. Harrod, C.F. Mactutus, M. Welch, C.E. Browning and R.M. Booze, University of South Carolina, Columbia, SC DRUG ABUSE IN ADOLESCENTS: ANIMAL STUDIES 21 Effects of CP-154,526 on cocaine and methamphetamine conditioned place preference in adolescent rats K.A. Carlson and N.E. Goeders, Louisiana State University, Shreveport, LA 22 Acquisition of amphetamine self-administration in periadolescent and adult rats M. Shahbazi, A. McQueen and K. Frantz, Georgia State University, Atlanta, GA 23 Effects of prenatal cocaine exposure and subsequent administration brain glucose metabolic rates in adolescent rats A. Torres-Reveron and D.L. Dow-Edwards, State University of New York Downstate, Brooklyn, NY 24 Sex and age effects on cocaine-stimulated motor behavior and voluntary, oral cocaine consumption Q.D. Walker, S.L. Parylak, J.M. Caster and C.M. Kuhn, Duke University Medical Center, Durham, NC 25 Enhanced behavioral profile in adolescents, but not adults, following cumulative dose cocaine administration J.M. Caster, Q.D. Walker and C.M. Kuhn, Duke University Medical Center, Durham, NC 26 Pre-exposure to cannabinoid agonist CP 55,940 during rat early adolescence facilitates acquisition of cocaine self-administration behavior in adulthood A. Higuera, M. Biscaia, B. Fernández, M. Miguéns, N. del Olmo, I. Torres, C. García- Lecumberri, M.P. Viveros and E. Ambrosio, Universidad Nacional de Educacion a Distancia, and UCM, Madrid, Spain 27 Nicotine sensitization in a rodent model of psychosis: A comparison of adult and adolescent rats R.W. Brown, M.K. Perna, K.J. Smith, A.M. Maple and J.R. Pauly, East Tennessee State University, Johnson City, TN and University of Kentucky, Lexington, KY 27.5 27.5 27.5 BADGES MUST BE WORN IN ALL SCIENTIFIC SESSIONS

30 Tuesday, June 21, 2005

GENES 28 Regulation of gene expression in microglia by cocaine versus interferon treatment V. Yuferov, D.A. Nielsen, S. Hu, P.K. Peterson and M.J. Kreek, The Rockefeller University, New York, NY and University of Minnesota Medical School, Minneapolis, MN 29 Cocaine alters the TNF-alpha-P38 MAPK pathway in primary human astrocytes C.T. Lee, J. Chen, S. Errico, T.P. Su, K.G. Becker and W.J. Freed, NIH/NIDA Intramural Research Program, NIA, Baltimore, MD 30 gene promoter repeat and cocaine and alcohol dependence T. Williams, K.S. LaForge, D. Gordon, G. Bart, S. Kellogg and M.J. Kreek, The Rockefeller University, New York, NY 31 Drug use in offspring of drug-dependent and unaffected twin fathers K. Bucholz, J. Grant, J. Scherrer, A. Duncan B. Waterman and T. Jacob, Washington University School of Medicine, Saint Louis University School of Public Health, WRS LLC, St. Louis, MO and Palo Alto VA Health Care Services, Menlo Park, CA 32 Using genotype to refine phenotype T.J. Crowley, M.C. Stallings, K.S. Krauter, R.P. Corley, K.M. Raymond, S.K. Mikulich- Gilbertson, S.E. Young, H.L. Gelhorn, J.M. Lessem and J.K. Hewitt, University of Colorado School of Medicine, Denver, and University of Colorado, Boulder, CO 33 Case-control and within-family tests for an association between conduct disorder and 5HTT-LPR using cases drawn from a substance abuse treatment program and controls J.T. Sakai, S.E. Young, M.C. Stallings, D. Timberlake, A. Smolen, G.L. Stetler and T.J. Crowley, University of Colorado School of Medicine, Denver, and University of Colorado, Boulder, CO 34 Antidepressant treatment moderates an association between DRD4 exon III VNTR alleles and harm avoidance in opioid-dependent men J. Perez-Cobos, N. Siñol, J. Trujols, M. Baiget, E. Bañuls, E. Del Rio, E. Luquero, A. Menoyo, M. Cardus, E. Alvarez and T. Barcelona Group for Addiction Genetics, Hospital Santa Creu i Sant Pau, Barcelona, Spain 35 Physiological, behavioral and subjective effects of acute caffeine administration in light, nondependent users H. de Wit, E.L. Childs and J. Deckert, The University of Chicago, Chicago, IL and University of Munster, Germany MARIJUANA - HUMAN STUDIES 36 Is marijuana a gateway to cocaine use? D.B. Clark, J.R. Cornelius and R.E. Tarter, University of Pittsburgh, Pittsburgh, PA 37 ALEXSA validity in high-risk, urban, mostly African American, 9-year-olds T.A. Ridenour, S. Mimes, L.T. Singer, A. Miller, A. Gottschall, and S. Satayathum, Pennsylvania State University, State College, PA and Case Western Reserve University, Cleveland, OH 38 Ethnicity, peer group affiliation and SES as predictors of drug use K. Engerman, J.O. Bailey and R.J. Harrison, Howard University, Washington, DC 39 Epidemiological surveillance: How well does YRBS predict MTF? K.M. Bohnert and J.C. Anthony, Michigan State University, East Lansing, MI 40 Cannabis withdrawal syndrome in 1603 current cannabis users from a national survey: Symptom prevalence and factor structure D. Hasin, S. Wang, E. Aharonovich and E. Nunes, Columbia University and New York State Psychiatric Institute, New York, NY 31 Tuesday, June 21, 2005

41 Timeline follow-back procedure for marijuana: How many joints in a blunt? J.J. Mariani, M. Haney, C.L. Hart and F.R. Levin, Columbia University and New York State Psychiatric Institute, New York, NY 42 Acute effects of smoked marijuana on gambling task performance N.P. Vadhan, C.L. Hart and R.W. Foltin, Columbia University and New York State Psychiatric Institute, New York, NY 43 Patterns and consequences of regular cannabis use in relation to employment, driving habits and interpersonal relationships: Survey and interview results from a UK sample P. Terry and K.A. Wright, University of Birmingham, Edgbaston, Birmingham, UK 44 Decision under risk in cannabis use disorders and schizophrenia S. Sevy, A. Bechara, H. Visweswariah, S. Meyer, B. Napolitano and E.V. Nunes, The Zucker Hillside Hospital, Glen Oaks, NY, University of Iowa, Iowa City, IA and Columbia University and New York State Psychiatric Institute, New York, NY 45 Opinions, perceptions and representations of cannabis among health educators in-training in France P. Courty, A. Simeone, C. Gardou and L. Gerbaud, Chu G.Montpied, Clermont Ferrand and Louis Lumière University, Lyons, France 46 Psychological characteristics of heavy marijuana abusers W. Better, R.I. Herning, K. Tate and J.L. Cadet, NIH/NIDA Intramural Research Program, Baltimore, MD 47 Effects of marijuana on the direction and variability of temporal discrimination in humans S.D. Lane, L.M. Lieving, D.R. Cherek, O.V. Tcheremissine and S.O. Nouvion, University of Texas-Houston Health Science Center, Houston, TX 48 Trait anxiety and marijuana use in pregnant women S. Meshberg-Cohen, D. Langhorst, T. Vance, K. Reid-Quiñones and D. Svikis, Virginia Commonwealth University, Richmond, VA 49 Associations between paternal history of drug dependence and offspring marijuana use J.D. Grant, J.F. Scherrer, A.E. Duncan, T. Jacob, B. Waterman and K.K. Bucholz, Washington University School of Medicine, St. Louis VA Medical Center, St. Louis University School of Public Health and WRS LLC, St. Louis, MO, and Palo Alto VA Health Care Services, Menlo Park, CA 50 Gabapentin as a treatment for concurrent cannabis and alcohol use disorders in an early stage proof-of-concept study T.J. Escher, S.B. Quello and B.J. Mason, The Scripps Research Institute, La Jolla, CA COCAINE BEHAVIOR AND TREATMENT - HUMAN STUDIES 51 The ability of oral cocaine to block the discriminative stimulus effects of intravenous cocaine in humans N. Lockhart, H. Schubiner, L. Lundhal and C.E. Johanson, Wayne State University, Detroit, MI 52 Effects of acute tiagabine administration on aggressive responses of healthy male volunteers L.M. Lieving, D.R. Cherek, S.D. Lane, O.V. Tcheremissine and S.O. Nouvion, University of Texas-Houston, Health Science Center, Houston, TX 53 Modafinil may be reinforcing in cocaine-dependent humans S.K. Vosburg, C.L. Hart, M. Haney and R.W. Foltin, Columbia University, and New York State Psychiatric Institute, New York, NY

32 Tuesday, June 21, 2005

54 An open-label trial of N-acetylcysteine for the treatment of cocaine dependence P.N. Mardikian, S.D. LaRowe, R.J. Malcolm, K.T. Brady and P.W. Kalivas, Medical University of South Carolina, Charleston, SC 55 Open-label pilot study evaluating dose tolerability of aripiprazole in cocaine-dependent patients G. Gonzalez, M. Sofuoglu, K. Gonsai, B. Martell, J. Poling and T.R. Kosten, Yale University, School of Medicine, New Haven and VA Connecticut Healthcare System, West Haven, CT 56 Cocaine withdrawal symptoms predict medication response in cocaine users K. Gonsai, M. Sofuoglu, J. Poling, G. Gonzalez and T.R. Kosten, Yale University, School of Medicine, New Haven and VA Connecticut Healthcare System, West Haven, CT 57 Effect of medicine on the Risk Assessment Battery in the treatment of cocaine dependence J.M. Harrer, T.M. Winhusen, S.P. Berger, R.J. Goldsmith, F. Kropp, J.P. Mezinskis, A. Elkashef and E.C. Somoza, VA Medical Center/University of Cincinnati, Cincinnati, OH, NIDA, Bethesda, MD and VA Medical Center, Portland, OR 58 “Incubation” of cocaine relapse during a disulfiram clinical trial T.R. Kosten, T.A. Kosten, J. Poling and A. Oliveto, Yale School of Medicine, New Haven, CT and University of Arkansas for Medical Sciences, Little Rock, AR 59 A within-session measure of cognitive abilities: Relation to relapse prevention outcome E. Aharonovich, A. Brooks, A. Bisaga, D.S. Hasin and E.V. Nunes, Columbia University and New York State Psychiatric Institute, New York, NY 60 The relationship of neurocognitive deficits in drug-addicted clients to change talk during behavioral therapy and subsequent behavioral outcomes P.C. Amrhein, E. Aharonovich, A. Brooks and E.V. Nunes, Montclair State University, Montclair, NJ, New York State Psychiatric Institute, and Columbia University, New York, NY 61 Effectiveness of motivational incentives for drug abuse recovery in multiple treatment history and treatment-naïve outpatients T.K. Killeen, M.L. Copersino and M.L. Stitzer, Medical University of South Carolina, Charleston, SC, NIH/NIDA Intramural Research Program, and Johns Hopkins University, Baltimore, MD 62 Illusory predictors: Generalizability of findings in cocaine treatment retention research A.L. Stotts, M.E. Mooney, S.L. Sayre, J.M. Schmitz and J. Grabowski, University of Texas Medical School-Houston, Houston, TX 63 Apathy as a predictor of cocaine-induced craving T.F. Newton, A.D. Kalechstein, R. de la Garza, II, D.J. Cutting and W. Ling, University of California, Los Angeles, CA 64 A meta-analytic review of cocaine-induced craving J.J. Mahoney, III, A.D. Kalechstein, R. de la Garza, II and T.F. Newton, University of California, Los Angeles, CA 65 Virtual reality cue reactivity in crack cocaine dependence M.E. Saladin, B.O. Rothbaum, K. Graap and K.T. Brady, Medical University of South Carolina, Charleston, SC, Emory University School of Medicine, and Virtually Better Inc., Atlanta, GA 66 Cocaine self-administration in humans: Relationship with abuse patterns and traits S.L. Walsh, E.C. Donny, G.E. Bigelow and A. Umbricht, Johns Hopkins School of Medicine, Baltimore, MD

33 Tuesday, June 21, 2005

67 Alexithymia in single- and dual-dependent substance users S.L. Sayre, A.L. Stotts, C. Green, A. Chawdhary and J. Crockett, University of Texas- Houston, Houston, TX 68 Technology transfer of behavioral day treatment with contingency management for dually diagnosed homeless substance abusers: Homelessness at follow-up A. Llewellyn, W. Norwood, P. Averill, J. Schumacher, J. Milby and H. Rhoades, University of Texas-Houston, University of Houston-Clear Lake, Houston, TX and University of Alabama School of Medicine, Birmingham, AL 69 Alcohol diagnoses showed improvement among homeless after day treatment for cocaine addiction in Birmingham Homeless Cocaine Study 3 J.E. Schumacher, J.B. Milby, D. Wallace, R. Vuchinich, S. Kertesz, M. Roberts, M. Furman and M. Vikinsalo, The University of Alabama at Birmingham, Birmingham, AL and RHO, Inc. COCAINE EPIDEMIOLOGY 70 Incident cases of crack use in the United States, 2002-2003 L.H. Caris, K.M. Bohnert, R.D. Hines and J.C. Anthony, University of Chile de Santiago, Santiago, Chile and Michigan State University, East Lansing, MI 71 Similarities in treatment admission on the U.S.-Mexico border J.C. Maxwell, P. Cravioto and M. Cortes, University of Texas at Austin, Austin, TX and Secretaria de Salud, Mexico City, Mexico 72 Characteristics of female cocaine users with access to firearms L.B. Cottler, C. Callahan Meeks and A. Ben Abdallah, Washington University School of Medicine, St. Louis, MO 73 Characteristics of cocaine users who buy and sell sex C.L.W. Striley and L.B. Cottler, Washington University School of Medicine, St. Louis, MO 74 Risky business: Sexual behaviors in cocaine-dependent individuals J.R. Kleinheider, S.E. Afful, L.B. Cottler and L.J. Bierut, Washington University School of Medicine, St. Louis, MO 75 Change in high-risk sexual behaviors between community and court-recruited female cocaine users in St. Louis C. Callahan Meeks, S. Bradford, A. Ben Abdallah and L.B. Cottler, Washington University School of Medicine, St. Louis, MO 76 Predictors of entry into treatment of cocaine base paste and cocaine hydrochloride users: A cohort study R. Santis, C.G. Hidalgo, V. Hayden, E. Anselmo, S. Ruiz, M.J. Mezzera, R. Torres, J. Rodriguez, F. Cartajena, J. Dreyse, L. Toro and M.J. Jimenez, Pontificia Universidad Catolica de Chile, Santiago, Chile COMORBIDITY II: PTSD, ADHD, AND ASPD 77 Traumatic event and PTSD assessment in out-of-treatment injection opioid users J.M. Peirce, E.R. Disney, M.S. Kidorf and R.K. Brooner, Johns Hopkins University School of Medicine, Baltimore, MD 78 Pathways between childhood victimization and adult sex trading among substance-using women V.A.S. Krishna, C. Meeks, A. Ben Abdallah and L. Cottler, Washington University School of Medicine in St. Louis, St. Louis, MO 79 Psychosocial, substance use and psychiatric correlates of post-traumatic stress disorder in treatment-seeking pathological gamblers D.M. Ledgerwood and N.M. Petry, University of Connecticut Health Center, Farmington, CT 34 Tuesday, June 21, 2005

80 Utility of the URICA-T to predict attrition in a study of PTSD and alcohol dependence T.L. Linkovich-Kyle, S.F. Coffey and P.R. Stasiewicz, University of Mississippi Medical Center, G.V. (Sonny) Montgomery VA Medical Center, Jackson, MS, University of Central Florida, Orlando, FL and State University of New York at Buffalo, Buffalo, NY 81 Co-occurring trauma and substance use disorders in patients with and without PTSD: Effect on treatment retention M.P. McGovern and R.D. Weiss, Dartmouth Medical School, Lebanon, NH and Harvard Medical School, Boston, MA 82 Assessment of drug-taking situations in post-traumatic stress disorder and co-occurring substance dependence M.L. Verduin, S.E. Back, K.T. Brady, A.L. McRae, A.E. Waldrop, A.E. Sensenig and U. Jaanimagi, Medical University of South Carolina, Charleston, SC 83 Self-medication in women with post-traumatic stress disorder and marijuana and/or alcohol use disorders: A pilot laboratory study of drug effects J.W. Hopper, M. Cote, S.E. Lukas, McLean Hospital/Harvard Medical School, Belmont, MA 84 Subjective stress reactivity before and after cold pressor task in individuals with substance dependence and PTSD A.L. McRae, K.T. Brady, S.E. Back, A.E. Waldrop, H. Upadhyaya, M.E. Saladin and A.E. Sensenig, Medical University of South Carolina, Charleston, SC 85 Complicated grief and substance use in methadone maintenance patients: A survey study K. Shear, A. Zuckoff, E. Frank, D. Daley, J. Cornelius, P. Houck, R. Silowash, S. Choder and R. Poropatich, University of Pittsburgh School of Medicine, Pittsburgh, PA 86 Complicated grief treatment for persons with substance use disorders: A pilot study A. Zuckoff, E. Frank, D. Daley, J. Cornelius, K. Seligman, R. Silowash and K. Shear, University of Pittsburgh School of Medicine, Pittsburgh, PA 87 A computerized continuous performance task-assessing treatment outcome of adult ADHD in methadone maintenance patients D.J. Brooks, S.M. Evans and F.R. Levin, Columbia University and New York State Psychiatric Institute, New York, NY 88 Effect of oral methylphenidate maintenance on the subjective and cardiovascular effects of cocaine in adults with ADHD S.L. Collins, F.R. Levin, R.W. Foltin and S.M. Evans, Columbia University and New York State Psychiatric Institute, New York, NY 89 Treatment of cocaine-dependent treatment seekers with adult ADHD: A double-blind comparison of methylphenidate and placebo F.R. Levin, S.M. Evans, D.J. Brooks and F. Garawi, Columbia University and New York State Psychiatric Institute, New York, NY 90 Nicotine dependence is more strongly associated with ADHD inattention symptoms than hyperactive/impulsive symptoms in a nationally representative sample of young adults S.H. Kollins, B.F. Fuemmeler and F.J. McClernon, Duke University Medical Center, Durham, NC and National Cancer Institute, Bethesda, MD 91 Smoking patterns and Attention-Deficit Hyperactivity Disorder symptoms among treatment- seeking cocaine-dependent adults M. Jung, D.J. Brooks, S.M. Evans and F.R. Levin, Columbia University and New York State Psychiatric Institute, New York, NY 92 Antisocial personality and stress-induced brain activation in cocaine-dependent individuals – potential sex differences C.R. Li, T.R. Kosten and R. Sinha, Yale University, New Haven, CT 35 Tuesday, June 21, 2005

93 Borderline personality and substance use in women U. Feske, R.E. Tarter, L. Kirisci and P.A. Pilkonis, University of Pittsburgh and Medical Center, Pittsburgh, PA 94 Good treatment response in antisocial patients with chronic and severe opioid-dependence K.J. Neufeld, V. King, M. Kidorf, K. Kolodner and R.K. Brooner, School of Medicine, Johns Hopkins University, Baltimore, MD PERINATAL DRUG EXPOSURE - HUMAN STUDIES 95 Neonates of drug-dependent mothers in a university hospital in Mexico A. Gutierrez Padilla, R. Vargas-Lopez, M. de la Torre, L. Avalos and O. Campollo, UCINEX Antiguo Hospital Civil de Guadalajara, CUCS, Universidad de Guadalajara and Centro de Estudios de Alcoholismo y Adicciones, Guadalajara, Mexico 96 A computer-based brief motivational intervention for perinatal drug use: Preliminary results from a phase II clinical trial S.J. Ondersma, D.S. Svikis, J.R. Beatty, L.A. Strathdee and C.R. Schuster, Wayne State University, Detroit, MI and Virginia Commonwealth University, Richmond, VA 97 Assessment of recent maternal cocaine use in a longitudinal study of prenatal cocaine exposure E.S. Bandstra, V.H. Accornero, L. Xue, C.E. Morrow, V. Moodley and J.C. Anthony, University of Miami School of Medicine, Miami, FL and Michigan State University, East Lansing, MI 98 Effect of prenatal cocaine exposure on examiner-rated behavior at age 7: Pathways involving caregiver behavioral health V.H. Accornero, J.C. Anthony, C.E. Morrow, L. Xue and E.S. Bandstra, University of Miami School of Medicine, Miami, FL and Michigan State University, East Lansing, MI 99 Assessment of substance abuse risk factors in 9-year-old prenatally drug-exposed children using the ALEXSA S. Minnes, T.A. Ridenour, L.T. Singer, A. Miller and S. Satayathum, Case Western Reserve University, Cleveland, OH and The Pennsylvania State University, State College, PA 100 Comparing pregnancy outcomes and cost efficacies of an aggressive outreach and referral programs for substance-abusing women U.O. Bailey, R.J. Harrison, A.L. English, R. Cox, D. Farr and B. Vayhinger, Howard University, Washington, DC, George’s Hospital Center, Healthy Babies and Center for Addiction and Pregnancy, Cheverly, MD 101 In vitro and in vivo effects of cocaine on the fetal-placental endocrine axis in humans A.D. Williams, B. Ahluwalia, L. Kaul and W. Pei, Howard University College of Medicine, Washington, DC 102 Methadone metabolism by pre-term human placentas T.L. Hieronymus, T.N. Nanovskaya, S.V. Deshmukh, G.D.V. Hankins and M.S. Ahmed, University of Texas Medical Branch, Galveston, TX 103 The effect of methadone, buprenorphine and levo-alpha- on human placental aromatase O.L. Zharikova, S.V. Deshmukh, T.N. Nanovskaya, I.A. Nekhayeva, G.D.V. Hankins and M.S. Ahmed, University of Texas Medical Branch, Galveston, TX 104 Role of P glycoprotein in transplacental transfer of methadone T.N. Nanovskaya, I.A. Nekhayeva, N. Karunaratne, K. Audus, G.D.V. Hankins and M.S. Ahmed, University of Texas Medical Branch, Galveston, TX and University of Kansas, Lawrence, KS

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105 Effect of nicotine-specific antibodies, Nic311 and Nic-IgG, on the transfer of nicotine across human placenta I. Nekhayeva, T. Nanovskaya, P. Pentel, G.D.V. Hankins and M. S. Ahmed, University of Texas Medical Branch, Galveston, TX and University of Minnesota, Minneapolis, MN 106 Retrospective examination of the relationship between maternal methadone dose and neonatal abstinence syndrome B. Shapiro, A. Martinez, M. Pletcher, N. Haug and S. Sniderman, University of California and San Francisco General Hospital, San Francisco, CA 107 Buprenorphine and methadone in pregnancy: Effects on the mother, fetus and neonate A.L. Gordon, H. Stacey, V. Pearson, R.R. Haslam, O.V. Lopatko and J.M. White, University of Adelaide, Women’s and Children’s Hospital, and Drug and Alcohol Services Council, Adelaide, Australia 108 What are the odds? A hazard analysis of drug use among opioid-dependent women S.R. Podolin and K. Kaltenbach, Thomas Jefferson University, Philadelphia, PA 109 History of physical abuse and problem drinking and drug use in pregnant women A.H. Alvanzo, L. Keyser-Marcus and D.S. Svikis, Virginia Commonwealth University, Richmond, VA 110 Reasons for drinking in pregnant smokers and non-smokers A. Sepulveda, L. Keyser-Marcus, D. Langhorst, J. Draper, S. Kornstein and D. Svikis, Virginia Commonwealth University, Richmond, VA 111 Where there’s smoke….. there’s fire? Applications for prenatal tobacco and other drug use D.S. Svikis, D. Langhorst, L. Keyser-Marcus, A. Alvanzo and K. Reid-Quinones, Virginia Commonwealth University, Richmond, VA 112 Biochemical verification of smoking status in pregnant and recently postpartum women S.T. Higgins, S.H. Heil, G.J. Badger, J.A. Mongeon, L.J. Solomon, L. McHale and I.M. Bernstein, University of Vermont, Burlington, VT 113 Less is more. Encouraging reductions in tobacco use with newly postpartum women L.A. Keyser-Marcus, G.C. Britt, L.D. Meloy, P. Kum-Nji, K. Reid-Quinones and D.S. Svikis, Virginia Commonwealth University, Richmond, VA 114 Voucher-based incentives for abstinence from cigarette smoking in pregnant and postpartum women S.H. Heil, S.T. Higgins, L. Solomon, I.M. Bernstein, M.E. Lynch, L. McHale, N. Jacuzzi and A. Dumeer, University of Vermont, Burlington, VT 115 Developmental effects of maternal smoking during pregnancy: Gender differences in cognitive functioning at ages five to six K. Grohman, E. Edwards, R. Eiden and K. Leonard, The State University of New York at Buffalo, Buffalo, NY SEDATIVE-HYPNOTICS, INHALANTS 116 Drug use and personality variables associated with abuse liability-related effects of D.J. Walker and A.M. Syvertsen, The University of Chicago, Chicago, IL 117 Inhalant use, practices, and perceptions: How accurately do health professionals perceive what inhalant users do? K. Chandler-Ezell, L. Hoffer, T. Ridenour, W. Reich, S. McCrary and L. Cottler, Washington University School of Medicine, St. Louis, MO and Pennsylvania State University, State College, PA

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118 Critical periods for the effects of toluene exposure on developmental delays in rats J.C. Batis, J.H. Hannigan and S.E. Bowen, Wayne State University, Detroit, MI 119 Toluene inhibits sodium currents in skeletal muscle sodium channels but not in the mutant F1579A in Xenopus laevis oocytes M.Y. Gauthereau, E.M. Salinas-Stefanón and S.L. Cruz, Cinvestav-IPN, Mexico, D.F., Mexico and BUAP, Puebla, Mexico 120 Amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice S.E. Bowen and E. Muhammad, Wayne State University, Detroit, MI 121 Behavioral effects of alprazolam in rhesus monkeys: Relationship with anti-conflict and reinforcing effects A.N. Duke, D.M. Platt and J.K. Rowlett, Harvard Medical School, New England Regional Primate Research Center, Southborough, and University of Massachusetts, Amherst, MA

122 Discriminative stimulus effects of the low-efficacy positive GABAA modulators L-838,417 and bretazenil in rhesus monkeys L.R. McMahon and C.P. France, University of Texas Health Science Center, San Antonio, TX 123 Comparison of the discriminative stimulus effects of pregnanolone and ethanol in rats L.R. Gerak, J.M. Moerschbaecher and P.J. Winsauer, Louisiana State University Health Sciences Center, New Orleans, LA 124 Acute effects of alprazolam on proactive and reactive aggression S.O. Nouvion, S.D. Lane, O.V. Tcheremissine, L.M. Lieving and D.R. Cherek, University of Texas Health Science Center-Houston, Houston, TX 125 decreases behavioral inhibition but not impulsive decision-making in adults A. Acheson, B. Reynolds, J.B. Richards and H. de Wit, University of Chicago, Chicago, IL and Research Institute on Addictions, Buffalo, NY 126 Dose-effect comparison of ramelteon and triazolam: Abuse potential and behavioral effects M.W. Johnson, P.E. Suess and R.R. Griffiths, Johns Hopkins University School of Medicine, Baltimore, MD 127 An in-patient, double-blind, placebo-controlled, evaluation of the abuse liability of Valium, Xanax IR and Xanax XR E. Yu, K. Williams, V. Dhopesh, K. Lynch and C.P. O’Brien, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 128 Evaluation of the subjective and reinforcing effects of , levetiracetam, and valproic acid D. Feltne, G. Haig and T. Hunt, Pfizer Inc., Ann Arbor, MI and PPD Development Clinics, Austin, TX PRESCRIPTION DRUG ABUSE 129 Patterns and clustering of symptoms of analgesic dependence: A latent class approach L.A. Ghandour, S.S. Martins and H.D. Chilcoat, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 130 Geospatial modeling of disparate data sources on prescription opioid abuse N. Dasgupta, J. Brownstein and S.H. Schnoll, Purude Pharma L.P., Stamford, CT and Children’s Hospital Boston, Harvard Medical School, Boston, MA 131 Surveillance of the RADARS System by poison control centers A.A. Hughes and R.C. Dart, Rocky Mountain Poison & Drug Center, University of Colorado Health Science Center, and Reporting for RADARS (R) System Poison Centers, Denver, CO

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132 A qualitative analysis of RADARS System key informant interviews T.R. Berry and S. Schnoll, Purdue Pharma L.P., Stamford, CT 133 Abuse, dependence and misuse of prescription opioid analgesics, benzodiazepines and carisoprodol in 7792 calls to poison control centers E.C. Senay, A. Geller, G. Woody, R.C. Dart, A.A. Hughes and M.Y. Smith, University of Chicago, Chicago, IL, Columbia University, New York, NY, University of Pennsylvania, Philadelphia, PA, Rocky Mountain PCC, Denver, CO and Purdue Pharma L.P., Stamford, CT 134 Clinician validation of poison control center calls involving abuse and misuse of prescription opioids M.Y. Smith, R.C. Dart, A. Hughes, A. Geller, E. Senay and G. Woody, Purdue Pharma L.P., Stamford, CT, Rocky Mt. Poison & Drug Center, Denver, CO, Columbia University, New York, NY, University of Chicago, Chicago, IL and University of Pennsylvania, Philadelphia, PA 135 Reducing the potential for diversion of prescription opioids: Intervention options A. Graham, M.Y. Smith, J.D. Haddox and C. Wright IV, Purdue Pharma L.P., Stamford, CT 136 RADARS System - Convergence/divergence of attitudes from law enforcement and drug treatment centers regarding prescription opioid abuse A. Kline and S. Schnoll, Purdue Pharma L.P., Stamford, CT 137 No prescription websites: Opioid medications available without a prescription R.F. Forman, A.T. McLellan and G.E. Woody, University of Pennsylvania and Treatment Research Institute, Philadelphia, PA 138 Gender differences in sources of prescription drugs for illicit use S.E. McCabe and C.J. Boyd, University of Michigan, Ann Arbor, MI 139 Characterizing prescription opiate abusers: Rural versus urban residence J.R. Havens, C.B. Oser, C.G. Leukefeld, J.M. Webster, S.S. Martin, G.J. Postle, D.J. O’Connell, J.A. Inciardi and H.L. Surratt, University of Kentucky, Lexington, KY and University of Delaware, Newark, DE 140 Analgesic-dependence symptom profiles in subgroups of extramedical analgesic users S.S. Martins, L. Ghandour and H.D. Chilcoat, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 141 Prospective investigation of abuse in a Phase 3 clinical trial C. Wright IV, E.D. Kramer and M. Zalman, Purdue Pharma L.P., Stamford, CT 142 Changes in OxyContin® use among treatment seekers: Data from the DENS study D. Carise, A. Camilleri, A.T. McLellan and G. Woody, Treatment Research Institute and University of Pennsylvania, Philadelphia, PA 143 The treatment of oxycodone abuse: Organizational predictors of admissions H.K. Knudsen, L.J. Ducharme, J.A. Johnson and P.M. Roman, The University of Georgia, Athens, GA 144 Correlates of illicit methadone use in New York City S. Galea, D.C. Ompad, C.A. Chan, D. Vlahov and C.M. Fuller, New York Academy of Medicine, New York, NY and Columbia University, New York, NY 145 Sensitization in the operating room: Fentanyl exposure, abuse and dependence K. Frost-Pineda, R.J. Melker, R. Pomm, T. Morey, D. Dennis and M.S. Gold, University of Florida College of Medicine, Gainesville, and Professional Resource Network, Fernandina Beach, FL

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146 Profiling the subjective, psychomotor, and physiological effects of in recreational drug users J.P. Zacny, University of Chicago, Chicago, IL 147 Methods for retrospective analysis of abuse of study medication in clinical trials M. Zalman, E.D. Kramer and C. Wright IV, Purdue Pharma L.P., Stamford, CT 148 The effects of targeted media-based prevention messages on marijuana use by high-sensation and cognition-seeking young adults: An experimental analysis N.G. Harrington, D.R. Lane, R.S. Zimmerman, K.M. Lederer, C.A. Martin and T.H. Kelly, University of Kentucky, Lexington, KY PREVENTION AND POLICY 149 Predictors and correlates of early versus late initiation of substance use S.D. King, R. Sarasvita, R. Schwartz, B.S. Brown, E. Weintraub, W. Barksdale, R. Robinson and E.C. Katz, Friends Research Institute, Inc., Baltimore, MD, Drug Dependence Hospital, Indonesia, University of North Carolina, Wilmington, NC and University of Maryland, Baltimore, MD 150 Early substance initiation and impulsivity, inattention, perceived safeness, and chronic stress A. Miller, L.F. Zinn, and T.A. Ridenour, Pennsylvania State University, State College, and The Second Mile, State College, PA 151 Drug abuse prevention in Latin immigrant population in the autonomous region of Valencia (Spain) S. Tortajada, M.J. Perez, M. Castellano, L. Alapont, A. Vidal, R. Aleixandre, J.C. Valderrama and J.C. Perez de los Cobos, Instituto de Historia de la Ciencia y Documentación Lopez Piñero (UV-CSIC), Generalitat Valenciana, AEPA, FEPAD, Valencia, and Hospital Sant Pau i la Santa Creu, Barcelona, Spain 152 Maternal substance abuse, childhood and current victimization among battered women in New York City T. Jospitre, R.E. Sage, S. Griffing, M. Chu, L. Madry and B.J. Primm, Urban Resource Institute, New York, NY 153 Researching the decline in heroin treatment admissions in California: Is Proposition 36 a determining factor? M. Hardy, Y. Hser and Y. Huang, University of California, Los Angeles, CA 154 Short-term outcomes of Proposition 36 in five California counties Y. Hser, E. Evans and J. Fan, University of California, Los Angeles, CA 155 California’s Proposition 36: County stakeholders’ perspectives on the new law and recommendations for changes C. Teruya, M. Hardy and Y. Hser, University of California, Los Angeles, CA 156 How fixed prices of heroin coexist with variations in consumer demand within a local heroin market L.D. Hoffer, S.K. Koester, A. Ben Abdallah and L.B. Cottler, Washington University School of Medicine, St. Louis, MO and University of Colorado at Denver, Denver, CO 157 Impact of opioid abuse from the managed care perspective V. Sikirica, S. Vallow, J. Schein, D. Doshi, N. Katz, A. White and H. Chilcoat, Jefferson Medical College, Philadelphia, PA, Janssen Medical Affairs, L.L.C., Titusville, NJ, Center for Opioid Research, Inflexxion, Inc., Newton, MA, Analysis Group, Inc., Boston, MA and Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD

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158 Cultural understandings of anabolic steroids use among fitness centers users A. Vidal, J. Aguilar, M. Castellano, J.C. Valderrama, M.C. Hernandez and J.C. Perez de los Cobos, FEPAD, Conselleria de Sanitat, Generalitat Valenciana, Universidad de Valencia and Hospital de la Santa Creu i Sant Pau, Barcelona, Spain 159 Salience of follow-up payments: Does size really matter? J.R. Croft, D.S. Festinger, D.B. Marlowe, N.K. Mastro and P.A. Lee, Treatment Research Institute, Philadelphia, PA 160 Variables associated with increased environmental scanning: Implications for increasing the absorptive capacity of substance abuse treatment facilities A.L. Koch, C.L. Arfken, M.W. Dickson, E. Agius and J.K. Mitchelson, Wayne State University, Detroit, MI Symposium IX Crown Hall 10:00 AM - 12:00 PM GLUTAMATERGIC MODULATION OF DRUG REINFORCEMENT, TOLERANCE, AND DEPENDENCE

Chairs: Rebecca Craft and Sandra Comer 10:00 Glutamatergic modulation of drug tolerance/sensitization: Animal studies Keith Trujillo, California State University San Marcos, San Marcos, CA 10:25 Glutamatergic modulation of opioid reinforcement and dependence: Animal studies Piotr Popik, Polish Academy of Sciences, Krakow, Poland 10:50 Glutamatergic modulation of psychostimulant reinforcement and dependence: Animal studies Richard M. Allen, University of Colorado at Denver and Health Sciences Center, Denver, CO 11:15 NMDA receptor antagonist modulation of drug dependence in human subjects Sandra Comer, Columbia University, New York, NY 11:40 Current issues in research on and treatment of drug addiction using glutamate inhibitors Discussant: Rebecca Craft, Washington State University, Pullman, WA Oral Communications XII Scotland 10:00 AM - 12:00 PM FOCUS ON IMAGING

Chairs: Daniel Langleben and Laurie A. Zawertailo 10:00 fMRI of craving states in pathological gambling and cocaine dependence M.N. Potenza, P.C. Gottschalk, P. Skudlarski, R.K. Fulbright, C.M. Lacadie, M.K. Wilber, M.A. Steinberg, B.J. Rounsaville, T.R. Kosten, J.C. Gore, R.T. Constable and B.E. Wexler, Yale University School of Medicine, New Haven, and Connecticut Council on Problem Gambling, Guilford, CT 10:15 EEG and cerebral blood flow velocity abnormalities in chronic cocaine abusers correlate with intensity of cocaine use D.A. Gorelick, M.L. Copersino, W. Better, R.I. Herning, J.L. Cadet, R.A. Nelson, and S.J. Boyd, NIH/NIDA Intramural Research Program, Baltimore, MD

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10:30 Behavioral and neural activity differences between methamphetamine abusers and controls performing a delay discounting task J.R. Monterosso, C.P. Domier, X. Cordova, G. Ainslie, J. Xu and E.D. London, University of California, Los Angeles, CA and Coatesville VA Medical Center, Coatesville, PA 10:45 fMRI changes associated with deficits in inhibitory processing in marijuana smokers S.A. Gruber, J. Rogowska, P. Pimentel, A. Cerny and D.A. Yurgelun-Todd, McLean Hospital, Harvard Medical School, Belmont, MA 11:00 Personality and fMRI response among abstinent adolescent marijuana users A.D. Schweinsburg, A. Park, C. Burke, G.F. Koob, and S.F. Tapert, University of California, La Jolla, Veterans Medical Research Foundation, San Diego, and The Scripps Research Institute, La Jolla, CA 11:15 Brain 1H MR spectroscopy, cognitive functioning and treatment outcome in tobacco-dependent subjects C.G. Schütz, W. Block, F. Träber, O. Eichler, G. Bopp, F. Schildberg, M. Wagner, H.H. Schild and W. Maier, Friedrich-Wilhelms-University, Bonn, Germany 11:30 Response to acute amphetamine administration in comorbid nicotine dependence and major depression: Subjective reports and effects of positron emission tomography L. Zawertailo, L. Cardenas, H. Mayberg and U. Busto, University of Toronto, Canada 11:45 Perfusion magnetic resonance imaging of opiate-dependent patients exposed to drug-related cues D.D. Langleben, S. Busch, N.E. Sciortino, J. Wang, Z. Wang, J. Listerud, C.P. O’Brien and A.R. Childress, University of Pennsylvania Health System, Philadelphia, PA

Oral Communications XIII Ireland 10:00 AM - 12:00 PM EPIDEMIOLOGY, PREVENTION, COMORBIDITY AND TREATMENT

Chairs: Valerie S. Harder and Yan Wang 10:00 Introduction Howard D. Chilcoat, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 10:15 More epidemiological evidence on cocaine use and occurrence of panic in young adults G.F. Alvarado and J.C. Anthony, Universidad Peruana Cayetano Heredia, Lima, Peru and Michigan State University, East Lansing, MI 10:30 Long-term quality of life outcomes among healthy young adults who use illicit drugs (the Cardia Study) S.G. Kertesz, M. Pletcher, S. Person, J. Halanych, S. Taylor, J. Schumacher and C. Kiefe, University of Alabama Birmingham at Birmingham, AL, University of San Francisco, and University of California, Los Angeles, CA 10:45 Early sexual experiences increase the risk to initiate illegal drug use at a later age Y. Wang, C.L. Storr, F.A. Wagner, D.C. Browne, Morgan State University, Baltimore, MD

42 Tuesday, June 21, 2005

11:00 Psychiatric comorbidity and progression in drug use in adult male twins A. Todorov, J. Grant, M. Lynskey, J. Scherrer and K. Bucholz, Washington University School of Medicine, St. Louis, MO 11:15 Mental health treatment utilization by adults with drug dependence and mental health problems: An analysis of the 2002 national survey on drug use and health K.M. Dowling and H.D. Chilcoat, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 11:30 Drug-use disorders and the relationship with latent classes of depression V.S. Harder and H.D. Chilcoat, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 11:45 Post-traumatic stress disorder is closely associated with substance-use disorders in primary care J. Liebschutz, V. Brower, C. Lloyd-Travaglini, R. Saitz and J. Samet, Boston University School of Medicine, Boston, MA Oral Communications XIV England 10:00 AM - 12:00 PM BEHAVIORAL INTERVENTIONS

Chairs: Carl G. Leukefeld and Jennifer P. Lussier 10:00 Contingent fee rebates: A practical, affordable, revenue-generating and effective way to reduce drug use during outpatient treatment of opioid dependence L. Amass, J.B. Kamien, T.S. Samiy, C. Reiber, C.E. Noe, S.A. Gelacio, A. J. Cohen and U. Barkai, Friends Research Institute, Inc., Los Angeles, CA and Aegis Medical Systems, Agoura Hills, CA 10:15 A meta-analysis of voucher-based reinforcement therapy for substance-use disorders J.P. Lussier, S.H. Heil, J.A. Mongeon, G.J. Badger and S.T. Higgins, University of Pennsylvania, Treatment Research Institute, Philadelphia, PA and University of Vermont, Burlington, VT 10:30 Motivational incentives in methadone-maintained abusers: 6-month follow-up results M.L. Stitzer, J. Peirce, C. Wong and J. Roll, Johns Hopkins University School of Medicine, Baltimore, MD and Washington State University, Pullman, WA 10:45 Impact of group motivational interviewing for dually diagnosed patients E.J. Santa Ana and P.J. Nietert, Medical University of South Carolina, Charleston, SC 11:00 CM for housing and work performance are sufficient to establish sustained abstinence in homeless substance abusers J.B. Milby, J.E. Schumacher, D. Wallace, M.J. Freedman, S. Kertesz, M. Viikinsalo and R.E. Vucinich, University of Alabama at Birmingham, Birmingham, AL and RHO Federal Systems Division Inc., Chapel Hill, NC 11:15 Contingency management in drug court D.B. Marlowe, D.S. Festinger, P.A. Lee, G. Fox, R. Alexander, N.K. Mastro and J.M. Caughie, Treatment Research Institute, University of Pennsylvania, Philadelphia, PA 11:16 11:16 11:16 BADGES MUST BE WORN IN ALL SCIENTIFIC SESSIONS

43 Tuesday, June 21, 2005

11:30 The role of “intent to seek treatment” among drug users legally mandated to treatment V.A. Stanick, A. Laudet, K. Morgen, J. Carway and B. Sands, National Development and Research Institutes, Inc., VIP Community Services, Inc., New York, NY and New York Health and Hospitals Corporation/Woodhull Hospital Center, New York, NY 11:45 Employment and work: 12-month randomized trial outcomes C.G. Leukefeld, M. Staton Tindall, J.M. Webster, J.L. Duvall, A. Mateyoke-Scrivner, J. Havens, C. Oser, M. Schumacher, T.F. Garrity, H. Smiley-McDonald and T.K. Logan, University of Kentucky, Lexington, KY

Late-Breaking Research News Great Hall 12:00 - 1:00 PM Chair: Sharon Walsh

Grant-Writing Workshop Knave/Scribe (Pre-Registrants Only) 1:15 - 5:00 PM

Chair: Denise Pintello Welcoming Remarks Timothy P. Condon and Suman R. King National Institute on Drug Abuse

Workshop IX Ireland 8:00 - 10:00 PM 11TH ANNUAL CONTINGENCY MANAGEMENT WORKING GROUP

Chair: Stacey Sigmon

Workshop X Crown Hall 8:00 - 10:00 PM DATA SAFETY MONITORING FOR CLINICAL TRIALS IN HEALTH SERVICES RESEARCH

Chairs: Wilson M. Compton and Michael L. Dennis NIH and NIDA policies regarding Data Monitoring Boards for multi-site and phase III clinical trials Redonna K. Chandler, NIDA, Bethesda, MD The practical and effective use of DSMB in Health Services Research Michael L. Dennis, Chestnut Health Systems, Bloomington, IL HIV community interventions for drug-involved women: Risks of partner abuse, self- empowerment and safety planning Nabila El-Bassel, Columbia University, New York, NY

44 Tuesday, June 21, 2005

DSMB issues in conducting research in criminal justice settings Gary Field, Private Practice, Salem, OR Medical adverse events and DSMBs Robert P. Schwartz, Friends Research Institute, Baltimore, MD Discussant Ivan Montoya, NIDA, Bethesda, MD

Wednesday, June 22, 2005

POSTER SESSION III (Breakfast) Exhibition Hall 8:00 - 10:00 AM Odd-numbered posters manned first hour; Even-numbered, second hour

Set-up time begins Tuesday 1:00 PM Must be removed by Wednesday 12:30 PM METHAMPHETAMINE, AMPHETAMINE - HUMAN STUDIES 1 Comparison of gray matter densities between short-term abstinent methamphetamine users and long-term abstinent methamphetamine users J. Kim, I.K. Lyoo, S.J. Kim, J. Hwang, A. Chung, Y.H. Sung and P.F. Renshaw, Seoul National University College of Medicine and Hospital, Seoul, Korea and McLean Hospital Brain Imaging Center, Belmont, MA 2 Medial model-based and boundary model-based shape analysis of the corpus callosum in abstinent methamphetamine users S.J. Bae, I.K. Lyoo, J.S. Oh, S.J. Kim, Y.H. Sung, J. Hwang, J. Kim, A. Chung, I.C. Song and P.F. Renshaw, Seoul National University College of Medicine and Hospital, Seoul, Korea and McLean Hospital Brain Imaging Center, Belmont, MA 3 Impaired response inhibition associated with chronic methamphetamine abuse X. Cordova, J.R. Monterosso, A. Aron, J. Xu and E.D. London, University of California, and Geffen School of Medicine, Los Angeles, CA 4 A dissociation of the subjective and cardiovascular effects produced by cocaine or methamphetamine in stimulant-addicted patients R. de la Garza, II, A.D. Kalechstein, L. Nestor and T.F. Newton, University of California, Los Angeles, CA 5 Methamphetamine self-administration by humans subjected to simulated shift work C.L. Hart, M. Haney, S.K. Vosburg, S.D. Comer and R.W. Foltin, College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, New York, NY 6 An examination of sleep alterations in methamphetamine-addicted patients B. Jackson, R. de la Garza, II and T.F. Newton, University of California, Los Angeles, CA 7 Open-label pilot trials of and modafinil in inpatient methamphetamine withdrawal: Symptoms and sleep patterns C. McGregor, J.M. White, M. Srisurapanont, A. Mitchell and W. Wickes, University of Adelaide, Australia, Chiang Mai University, Thailand and Drug and Alcohol Services Council, Australia 45 Wednesday, June 22, 2005

8 Baclofen does not attenuate the physiological or subjective effects of oral methamphetamine in humans T.M. Cederlind and C.E. Johanson, Wayne State University, Detroit, MI 9 A randomized, placebo-controlled trial of gabapentin or baclofen for methamphetamine dependence S. Shoptaw, J. Peck, X. Yang, M. Torrington and W. Ling, David Geffen School of Medicine at University of California and Friends Research Institute, Los Angeles, CA 10 does not modulate the discriminative-stimulus or subject-rated effects of d-amphetamine in humans J.A. Lile, W.W. Stoops, F.P. Wagner, P.E.A. Glaser and C.R. Rush, University of Kentucky College of Medicine, Lexington, KY 11 d-Amphetamine self-administration in high- and low-impulsive sensation seekers using a progressive-ratio procedure T.H. Kelly, W.W. Stoops, G. Robbins, C.A. Martin, J.A. Lile, M.T. Bardo and C.R. Rush, University of Kentucky, Lexington, KY 12 Open-label trial of risperidone for methamphetamine dependence A.J. Saxon, C. Jaffe, C.W. Meredith, E. Yanasak, M. Cherrier, K. Ang-Lee and K.A. Straits- Troster, University of Washington and VA Puget Sound Health Care System, Seattle, WA and VA National Center for Prevention and Duke University, Durham, NC 13 Differences in women methamphetamine and cocaine users seeking residential treatment: Characteristics and predictors of premature discharge L. White, A.J. Rush, V. Nguyen, H. Voet, T. Carmody and B. Crowell, University of Texas- Southwestern Medical Center, Dallas, TX and NEXUS Recovery Center, Inc., Dallas TX 14 Gender and ethnic differences in treatment utilization, satisfaction and outcomes among methamphetamine abusers N. Niv and Y. Hser, University of California, Los Angeles, CA 15 Comparing methamphetamine and non-methamphetamine substance abusers: One-year treatment outcomes C.Walker, V. Slaymaker and L. Neudahl, Butler Center for Research at Hazelden, Center City, MN 16 Assessing psychological disorders among methamphetamine users: The Multiyear Methamphetamine Treatment Follow-Up Study P. Marinelli-Casey, M.P. Hillhouse and R. Rawson, University of California, Los Angeles, CA 17 Methamphetamine treatment: Trends and predictors of retention and completion in a large state treatment system (1992-2002) M. Brecht and L. Greenwell, University of California, Los Angeles, CA ADOLESCENTS: ABUSE OF STIMULANTS, OPIOIDS, AND ALCOHOL 18 Are adolescents who enter outpatient treatment starting their treatment careers? S.H. Godley, R.R. Funk and M.D. Godley, Chestnut Health Systems, Bloomington, IL 19 A comparison of buprenorphine/ adolescent opiate subjects and the Drug Evaluation Network Study G.E. Woody, University of Pennsylvania, Philadelphia, PA and Treatment Research Institute, Philadelphia, PA

46 Wednesday, June 22, 2005

20 Pre- and post-treatment patterns of substance use among adolescents seeking treatment for heroin use P. Clemmey, L. Payne, J. Rhodes and M. Fishman, Potomac Healthcare Foundation, Mountain Manor Treatment Center and Johns Hopkins University, Baltimore, MD 21 The long-term neurodevelopmental evaluation of children born to drug-addicted parents raised in different environments, from birth to adolescence A. Ornoy, R. Bar Hamburger and C. Greenbaum, Hebrew University Hadassah Medical School, Jerusalem, Israel, Israel Anti Drug Authority, Jerusalem, Israel and Hebrew University, Jerusalem, Israel 22 Childhood and adolescent antecedents of drug use in adulthood M.E. Ensminger, H.S. Juon and K.E. Fothergill, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 23 Predictors of real-world risk behavior in young urban adolescents at risk for substance abuse M.R. MacDougall, R.N. Ehrman, C. Lejuez, H. Hurt M. Goldman, K. Marquez and A.R. Childress, University of Pennsylvania, University of Pennsylvania School of Medicine and Children’s Hospital of Philadelphia, Philadelphia, PA, and University of Maryland, College Park, MD 24 An affect-congruent Go-NoGo task for use with inner-city adolescents at risk for drug dependence M. Goldman, R.N. Ehrman, M. MacDougall, K. Marquez, J. Hakun, H. Hurt, A.R. Childress and C.P. O’Brien, University of Pennsylvania School of Medicine and Children’s Hospital of Philadelphia, Philadelphia, PA 25 Methamphetamine use among treatment-seeking adolescents in southern California: Participant characteristics and treatment response R.A. Rawson, R. Gonzales, J.L. Obert, M. McCann and P. Brethen, University of California and Matrix Institute on Addictions, Los Angeles, CA 26 Aggressive behaviors and methamphetamine use among youths in the United States M.S. O’Brien and H.D. Chilcoat, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 27 Drug use, childhood aggression and risk of repeating violent offenses Y.F. Chan, H.D. Chilcoat and J.C. Anthony, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD and Michigan State University College of Human Medicine, East Lansing, MI 28 Drug problems and the co-occurrence of behavioral disturbances in American youth C.L. Storr and V.H. Accornero, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD and University of Miami School of Medicine, Miami, FL 29 A multivariate look at drug-dealing among multi-problem male youths in the US, CY2003 I. Bustamante, C.F. Ríos-Bedoya and J.C. Anthony, University Cayetano Heredia Peruana, Lima, Peru, Johns Hopkins University, Baltimore, MD and Michigan State University, East Lansing, MI 30 Co-occurring conditions in adolescents with opioid use disorders versus marijuana/alcohol use disorders G. Subramaniam, M. Stitzer, P. Harrell and M.J. Fishman, Johns Hopkins University School of Medicine, Baltimore, MD and Mountain Manor Treatment Center, Baltimore, MD 31 Suicidal ideation among alcohol-use disordered adolescents in treatment and aftercare J.A. Burleson, Y. Kaminer, D.B. Goldston and R. Haberek, University of Connecticut Health Center, Farmington, CT and Duke University Child and Family Study Center, Durham, NC

47 Wednesday, June 22, 2005

32 Stability of comorbid psychiatric diagnoses among youths in AOSUD treatment J.M. Hawke, Y. Kaminer, J. Burleson and R. Haberek, National Development and Research Institutes, Inc., New York, NY and University of Connecticut Health Center, Farmington, CT 33 Adolescent reports of childhood trauma and current implications of sexual behaviors and illicit drug use H.T. Vo, W.M. Aklin, M.A. Bornovalova, M.A. Gwadz and C.W. Lejuez, University of Maryland College Park, College Park, MD and NDRI, New York, NY 34 Rates of alcohol abuse and dependence among school-based youth in the U.S., Mexico, and Puerto Rico V.C. Rojas, B.E. Mancha, L.J. Floyd, A.L. Lawson and W.W. Latimer, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 35 Young people and alcohol: Taste perception, attitudes and experiences J. Copeland, R. Stevenson, P. Gates and P. Dillon, University of New South Wales and Macquarie University, Sydney, Australia 36 Describing patterns of underage drinking in a community sample: A latent class analysis of data from the Enforcing Underage Drinking Laws program B.A. Reboussin, M. Wolfson, A. Shrestha and K.L. Lohman, Wake Forest University, Winston-Salem, NC and University of California, Los Angeles, CA 37 The Colorado youth leadership project: A rural adolescent drug prevention program K.J. Zavela, V. Battistich and K.S. Green, University of Northern Colorado, Greeley, CO, University of Missouri-St. Louis, St. Louis, MO and St. Vrain School District, Boulder, CO

ALCOHOL 38 The reliability of self-report and collateral reports of anger management styles and aggression among alcohol-dependent, domestic violence offenders T.M. Neavins and C.J. Easton, Yale University School of Medicine, New Haven, CT 39 Treatment outcome among substance-dependent offenders of intimate partner violence: A randomized clinical trial C.J. Easton, Yale University School of Medicine, New Haven, CT 40 Substance use and other risk factors related to interpersonal violence towards Latina immigrants: Recommendations to improve treatment programs for perpetrators M.J. Zarza, Behavioral Assessment Inc. Santa Monica, CA, and El Centro-Catholic Charities, Trenton, NJ 41 Content analysis of alcohol messages in Mexican TV soap operas O. Campollo, R. Ruiz and R. Chavez Lopez, University of Guadalajara and Antiguo Hospital Civil de Guadalajara, México 42 Coping with stressful events: Influence of parental alcoholism and race in a community sample of women M. Amodeo, M.L. Griffin, I. Fassler, C. Clay and M.A. Ellis, Boston University School of Social Work, Boston, MA 43 College students’ perceptions of alcohol, marijuana and sexual activity: Formative research using focus groups S.D. Ceperich, K.S. Ingersoll and T. Olds, Virginia Commonwealth University, Richmond, VA 44 Is there rapid onset of alcohol dependence clinical features when massed drinking occurs among early onset drinkers? C.F. Ríos-Bedoya and J.C. Anthony, Johns Hopkins University, Baltimore, MD and Michigan State University, East Lansing, MI 48 Wednesday, June 22, 2005

45 Elapsed time from onset of alcohol disorders to help-seeking R.G. Lopez, C.F. Rios-Bedoya and J.C. Anthony, Michigan State University, East Lansing, MI, Universidad del Valle, Cochabamba, Bolivia and Johns Hopkins University, Baltimore, MD 46 Psychosocial work environment and risk of becoming alcohol dependent P.L. Reed, J.C. Anthony and C.L. Storr, Michigan State University, East Lansing, MI and Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 47 A therapeutic workplace for homeless alcohol-dependent individuals C.J. Wong, K. Kolodner, M. Fingerhood, G.E. Bigelow and K. Silverman, Johns Hopkins University School of Medicine, Baltimore, MD 48 Characteristics of alcohol-addicted people who seek treatment in Khabarovsk, Russia A.R. Tkachenko, Far East State Medical University, Khabarovsk, Russia 49 Treatment outcomes among American Indians in California E. Evans, S. Spear, D. Huang and Y. Hser, University of California, Los Angeles, CA 50 Measuring external pressure to change: The Alcohol and Drug Confrontation Scale D.L. Polcin and G.P. Galloway, Haight Ashbury Clinics, Inc., San Francisco, CA 51 Acamprosate efficacy in alcohol-dependent patients: Summary of results from three pivotal studies A. Gage, S. Chabac and A. Goodman, Forest Laboratories, Inc., New York, NY, Lipha S.A., Lyon, France and Lipha Pharmaceuticals, Inc., New York, NY 52 Acamprosate is safe and well-tolerated for the treatment of alcohol dependence R.N. Rosenthal, A. Gage, J. Perhach and A. Goodman, Columbia University College of Physicians and Surgeons, New York, NY, Forest Laboratories, Inc., New York, NY and Lipha Pharmaceuticals, Inc., New York, NY 53 Using a flavorant-fading procedure to model alcohol-seeking behavior in rhesus macaques S.N. Katner, S.N. Von Huben, C.C. Lay, A.J. Kirsten, C.T. Flynn, S.A. Davis, M. Cole, H.S. Fox and M.A. Taffe, The Scripps Research Institute, La Jolla, CA 54 Concurrent assessment of taste and place conditioning with morphine, ethanol and LiCl G.R. Simpson and A.L. Riley, University of Miami, Miami, FL and American University, Washington, DC 55 Ethanol vapor self-administration in adult C57BL/6J male mice K.M. Kantak and C. Luzzo, Boston University, Boston, MA COCAINE BEHAVIOR - ANIMAL STUDIES 56 The DAT-selective 3-phenyltropane, RTI-371, antagonizes the in vivo effects of cocaine H.A. Navarro, J.L. Howard, G.T. Pollard and F.I. Carroll, RTI International, Research Triangle Park, NC and Howard Associates, Research Triangle Park, NC 57 Neurosteroids DHEAS and androsterone alter rat locomotor responses to cocaine in opposite directions Z. Graczyk, M.D. Majewska, W.F. Krol and C.W. Schindler, NIH/NIDA Intramural Research Program, and VA Maryland Health System, Baltimore, MD 58 -saporin infusions into the ventral tegmental area: Effects on basal and cocaine-evoked locomotor activity in rats E.J. Shank, S. Stutz and K.A. Cunningham, University of Texas Medical Branch, Galveston, TX

49 Wednesday, June 22, 2005

59 Neurochemical and behavioral responses to cocaine in adult male rats with neonatal isolation experience T.A. Kosten, X.Y. Zhang and P. Kehoe, Yale University School of Medicine, New Haven, CT and University of California, Irvine, CA 60 Effect of type 5 adenylyl cyclase knockout in cocaine-induced conditioned place preference and locomotor activity in mice Y. Zhang, S.D. Schlussman, A. Ho, Y. Ishikawa and M.J. Kreek, The Rockefeller University, New York, NY, and Yokohama City University School of Medicine, Yokohama, Japan 61 Reversal of behavioral sensitization to cocaine is associated with reversal of altered AMPA GluR1 subunit trafficking X. Zhang, W.C. Wetesel, C. Davidson, E.H. Ellinwood and T.H. Lee, Duke University Medical Center, Durham, NC 62 Effects of NMDA antagonists on primary and secondary reinforcing properties of cocaine J.L. Newman and P.M. Beardsley, Virginia Commonwealth University, Richmond, VA 63 Sensitization to the reinforcing effects of self-administered cocaine: Blockade by MK-801 Y. Liu, D.C.S. Roberts and D. Morgan, Wake Forest University School of Medicine, Winston-Salem, NC 64 Cocaine self-administration and food-maintained responding under FR and PR schedules of reinforcement: Comparison of C57BL/6J, 129X1/SvJ and 129S6/SvEvTac inbred mice M. Thomsen and S.B. Caine, McLean Hospital/Harvard Medical School, Belmont, MA and University of Copenhagen, Denmark 65 Effects of D1 antagonists and partial agonists on the relative reinforcing strength of cocaine in monkeys trained under concurrent schedules of food and cocaine availability C.A. Paronis, W. Tornatzky, M. Gasior and J. Bergman, McLean Hospital/Harvard Medical School, Belmont, MA 66 Effects of novel D3 compounds NGB 2904 and CJB 090 in monkeys trained to discriminate cocaine J. Martelle, J.T. Ross, A.H. Newman, and M.A. Nader, Wake Forest University School of Medicine, Winston-Salem, NC and NIH/NIDA Intramural Research Program, Baltimore, MD 67 Effects of dopamine D2/D3 ligands on cocaine self-administration and food-maintained responding under a concurrent choice schedule of reinforcement in rats A.C. Barrett, S.S. Negus and S.B. Caine, McLean Hospital/Harvard Medical School, Belmont, MA 68 Kappa opioid agonists induce partial reinstatement of cocaine-seeking behavior via non-opioid mechanisms G.R. Valdez, D.M. Platt, J.K. Rowlett and R.D. Spealman, Harvard Medical School, New England Primate Research Center, Southborough, MA 69 Effects of housing conditions during extinction on the conditioned cue-induced reinstatement of extinguished cocaine-seeking in rats L.J. Cheatwood, G.F. Guerin and N.E. Goeders, Louisiana State University, Health Science Center, Shreveport, LA 70 Blockade of the 5-HT2A receptor suppresses cue-evoked reinstatement in a rat self- administration model B.Á. Nic Dhonnchadha, J.J. Burmeister, R.G. Fox, A.M. Sandler and K.A. Cunningham, University of Texas Medical Branch, Galveston, TX 71 Place preference conditioned to a single trial with cocaine: Role of serotonin 2A receptors D.V. Herin, S.J. Stutz and K.A. Cunningham, University of Texas Medical Branch, Galveston, TX 50 Wednesday, June 22, 2005

72 Self-administration of mixtures of serotonergic or noradrenergic agents with d-amphetamine or cocaine by rhesus monkeys S. Wee and W.L. Woolverton, University of Mississippi Medical Center, Jackson, MS 73 Alterations in alpha2 noradrenergic receptor density in response to initial and chronic cocaine self-administration in non-human primate brain T.J.R. Beveridge, H.R. Smith, M.A. Nader and L.J. Porrino, Wake Forest University School of Medicine, Winston-Salem, NC 74 [3H]WIN 35,428 binding to the non-human primate dopamine transporter following protracted abstinence from cocaine self-administration H.R. Smith, T.J.R. Beveridge, M.A. Nader and L.J. Porrino, Wake Forest University School of Medicine, Winston-Salem, NC 75 Extended abstinence from cocaine self-administration: Effects on neural encoding of goal-directed behaviors in the accumbens J.A. Hollander and R.M. Carelli, University of North Carolina at Chapel Hill, NC 76 Orbitofrontal cortex fails to represent bad outcomes after cocaine exposure T.A. Stalnaker, M.R. Roesch, T. Franz, K.A. Burke and G. Schoenbaum, University of Maryland School of Medicine, Baltimore, MD 77 Context-dependent changes in drug-seeking and drug-taking behavior following prelimbic prefrontal cortex inactivation in rats N.C. Di Pietro and K.M. Kantak, Boston University, Boston, MA 78 Co-occurring dose-dependent cocaine-induced aversions and preferences conditioned in dopamine transporter knockout mice F.S. Hall, J.F. Randall-Thompson, A.L. Riley and G.R. Uhl, American University, Washington, DC and NIH/NIDA Intramural Research Program, Baltimore, MD 79 Assessment of sodium channel inhibition and general peripheral action in cocaine-induced conditioned-taste aversion K.B. Freeman, M.I. Konaklieva and A.L. Riley, American University, Washington, DC 80 Delay as a determinant of choice between a high dose and a low dose of cocaine by monkeys K.G. Anderson and W.L. Woolverton, University of Mississippi Medical Center, Jackson, MS and West Virginia University, Morgantown, WV 81 The discriminative stimulus effects of cocaine in high- and low-responder rats R.G. Fox, J.D. Ross and K.A. Cunningham, University of Texas Medical Branch, Galveston, TX COCAINE: GENES AND PROTEINS 82 Protein expression patterns during withdrawal from repeated cocaine exposure: A proteomics approach T. Geng, P.K. Seitz, M.L. Thomas and K.A. Cunningham, University of Texas Medical Branch, Galveston, TX 83 Protein expression during early acquisition of cocaine self-administration A.M. Sandler, E.C. Stoffel, B.Á. Nic Dhonnchadha and K.A. Cunningham, University of Texas Medical Branch, Galveston, TX 84 Response-dependent vs. -independent cocaine exposure: Expression of brain multidrug-resistant transporter transcripts M.F. Lanfranco, V. Palamarchouk, P.K. Seitz, M.L. Thomas, N. Goeders and K.A. Cunningham, University of Texas Medical Branch, Galveston, TX and Louisiana State University Health Science Center, Shrevesport, LA

51 Wednesday, June 22, 2005

85 Cocaine activation of c-fos and prodynorphin by MAP kinases in Fischer rats S. Jenab, E.D. Festa, A. Nazarian, H.B.K. Wu, R. Hazim, S.J. Russo and V. Quinones-Jenab, Hunter College of City University of NY, New York, NY 86 Deletion of the DARPP-32 Thr34 phosphorylation site attenuates cocaine-induced elevation of preprodynorphin in the caudate putamen of mice L.E. Bence, S.D. Schlussman, Y. Zhang, A. Ho, P. Svenningsson, P. Greengard and M.J. Kreek, The Rockefeller University, New York, NY 87 Steady vs. escalating dose chronic "binge" cocaine administration: A preproenkephalin and preprodynorphin gene expression study in the frontal cortex and hippocampus A. Bailey, S.D. Schlussman, A. Ho and M.J. Kreek, The Rockefeller University, New York, NY

METHYLPHENIDATE 88 Discriminative-stimulus and self-reported effects of methylphenidate, , d-amphetamine, and triazolam in methylphenidate-trained humans W.W. Stoops, T.M. Durell, P.E.A. Glaser, J.A. Lile, and C.R. Rush, University of Kentucky, Lexington, KY, and Eli Lilly and Company, Indianapolis, IN 90 Methylphenidate increases spontaneous smoking in humans A.R. Vansickel, C.R. Rush, S.T. Higgins, W.W. Stoops, J.A. Lile and P.E.A. Glaser, University of Kentucky College of Medicine, Lexington, KY and University of Vermont College of Medicine, Burlington, VT 91 Locomotor cross-sensitization between methylphenidate and nicotine in rats T.E. Wooters, N.M. Neugebauer and M.T. Bardo, University of Kentucky, Lexington, KY 92 Sex differences between young female and male Sprague-Dawley rats in response to methylphenidate N. Dafny, P.B. Yang and A.C. Swann, University of Texas Medical School at Houston, Houston, TX 93 Acute effect of methylphenidate on sensory-evoked responses in the VTA, PFC, and NAc of freely behaving rats P.B. Yang, A.C. Swann and N. Dafny, University of Texas Medical School at Houston, Houston, TX 94 Effect of acute and chronically administered or methylphenidate on dopamine transporter function Y.D. Williams and L.P. Dwoskin, University of Kentucky, Lexington, KY 95 Molecular mechanisms of the methylphenidate-induced psychostimulus effects: Comparison to methamphetamine T. Suzuki, K. Shindo, M. Miyatake and M. Narita, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan NICOTINE: ANIMAL STUDIES 96 Individual differences in nicotine modulation of the dopamine transporter in prefrontal cortex and in the locomotor stimulant effects of nicotine J. Zhu, M.E. Cain, M.T. Bardo and L.P. Dwoskin, University of Kentucky, Lexington, KY and Kansas State University, Manhattan, KS 97 Involvement of environmental stimuli in NCT-induced CPP and its neural mechanisms H. Miyata and T. Yanagita, Jikei University School of Medicine, Tokyo, Japan

52 Wednesday, June 22, 2005

98 Effects of nicotine withdrawal on performance under a progressive-ratio schedule of sucrose delivery in rats M.G. LeSage, D. Burroughs and P.R. Pentel, Minneapolis Medical Research Foundation, and University of Minnesota Medical School, Minneapolis, MN 99 Comparision of the effects of nitric oxide synthase inhibitors in nicotine-dependent rats R. Jain, K. Mukherjee, D. Mohan, All India Institute of Medical Sciences, New Delhi, India 100 Effect of a novel nicotinic receptor antagonist, N,N’-dodecane-1,12-diyl-bis-3 picolinium dibromide, on nicotine self-administration and locomotor activity in rats N.M. Neugebauer, Z. Zhang, P.A. Crooks, L.P. Dwoskin and M.T. Bardo, University of Kentucky, Lexington, KY CANNABINOIDS - ANIMAL STUDIES 101 (SR141716), a cannabinoid CB 1 receptor antagonist, was without effect in rhesus monkeys physically dependent on morphine M.D. Aceto, E.R. Bowman, L.S. Harris and B.R. Martin, Virginia Commonwealth University, Richmond, VA 102 Some behavioral effects of the novel CB1-receptor agonist AM 411 in squirrel monkeys M.S. Delatte, M. Zielstroff, G. Thakur, A. Makriyannis, and J. Bergman, McLean Hospital, Belmont, MA and University of Connecticut, Storrs, CT 103 The cannabinoid partial agonist AM251 attenuates nicotine-seeking and nicotine self- administration in rats M. Shoaib, Newcastle Medical School, Newcastle University, Newcastle, UK 104 Exploratory analysis of the effect of buprenorphine treatment on marijuana use I.D. Montoya, D.A. Gorelick, J.R. Schroeder, C. Contoreggi, K.L. Preston, R.E. Johnson and P.J. Fudala, NIDA/DPMC, Bethesda, MD, NIH/NIDA Intramural Research Program, Baltimore, MD, Johns Hopkins University, Baltimore, MD and University of Pennsylvania, Philadelphia, PA 105 Presence and functional expression of peripheral cannabinoid CB2 receptors in brain E.S. Onaivi, H. Ishiguro S. Patel, P.A. Meozzi, L. Myers, P.A. Tagliaferro, C.M. Leonard, E. Gardner, A. Brusco, B.E. Akinshola, Q.R. Liu, B. Hope and G.R. Uhl, William Paterson University, Wayne, NJ, NIDA/NIH, Baltimore, MD, Universidad de Buenos Aires, Argentina and Howard University, Washington, DC 106 Gene structure and transcript usage of the cannabinoid receptor 2 gene in immune cells of C57BL/6 mice T.A. Sherwood, L. Nong, M. Agudelo, H. Friedman and T.W. Klein, University of South Florida, Tampa, FL 107 Cannabinoid and LPS-induced fever K. Benamar, M. Yondorf, E.B. Geller and M.W. Adler, Temple University School of Medicine, Philadelphia, PA 108 Immunomodulation by : Altered cytokine responses of dendritic cells J. Rogers, I. Perkins, A. van Olphen, N. Burdash, T. Klein and H. Friedman, University of South Florida College of Medicine, Tampa, FL

108.5 BADGES MUST BE WORN IN ALL SCIENTIFIC SESSIONS

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HIV/AIDS, IMMUNE FUNCTION 109 SDF-1 antagonizes DAMGO-induced antinociception via the chemokine receptor CXCR4 X. Chen, E.B. Geller, M.S. Deitz, T.J. Rogers and M.W. Adler, Temple University School of Medicine, Philadelphia, PA 110 Effect of morphine withdrawal on oral Salmonella infection P. Feng, J.J. Meissler, Jr., M.W. Adler and T.K. Eisenstein, Temple University School of Medicine, Philadelphia, PA 111 Immunosuppression following morphine withdrawal is not mediated by corticosterone N.K. Thingalaya, J.J. Meissler, Jr., M.W. Adler and T.K. Eisenstein, Temple University School of Medicine, Philadelphia, PA 112 Naltrexone inhibits alcohol-mediated enhancement of HIV infection of T lymphocytes X. Wang, S.D. Douglas, D.S. Metzger, C.P. O’Brien, T. Zhang, L. Song and W.Z. Ho, Children’s Hospital of Philadelphia, Philadelphia, PA and University of Pennsylvania School of Medicine, Philadelphia, PA 113 Influence of an endocrine disruptor bisphenol-A in dopamine-dependent rewarding effect and astrocytic activation K. Miyagawa, M. Narita, M. Miyatake, K. Mizuo, M. Tomita and T. Suzuki, Hoshi University School of Pharmacy and Pharmaceutical Science, Tokyo, Japan 114 Cocaine differentially regulates the expression of mitogen-activated protein kinases in normal human astrocytes J.L. Reynolds, R. Chawda, B. Bindukumar, S.D. Mahajan, S.A. Schwartz and M.P. Nair, State University of New York at Buffalo, Buffalo, NY 115 EEG and cerebral blood flow velocity deficits in chronic cocaine abusers correlate with cocaine use R.I. Herning, K. Tate, W. Better and J.L. Cadet, NIH/NIDA Intramural Research Program, Baltimore, MD 116 CART: A promising intervention for cocaine use and non-adherence in people with HIV K.S. Ingersoll, C.J. Heckman, J. Cohen, J. Fife, S.D. Ceperich, M.Q. Lewis, T.O. Davis and N.J. Vandelinde, Virginia Commonwealth University, Richmond, VA 117 Readiness for medication adherence among HIV+ drug abusers J.E. Fife, K.S. Ingersoll and C.J. Heckman, Virginia Commonwealth University, Richmond, VA 118 Factors related to attrition in a modified directly observed therapy program for injection drug users with HIV disease E. McCance-Katz, J. Baker and C. Heckman, Virginia Commonwealth University, Richmond, VA 119 Methadone maintenance as HIV prevention R.E. Booth, N.L. Asdigian and K.F. Corsi, University of Colorado School of Medicine, Denver, CO 120 HIV physicians’ preparedness to prescribe buprenorphine for opioid dependence J. Tetrault, L.E. Sullivan, D. Bangalore and D.A. Fiellin, Yale University, New Haven, CT 121 Correlates of high-risk behavior among methadone and buprenorphine patients with HIV (COBRA) S.M. Apelt and H.U. Wittchen, Technical University of Dresden, Dresden, Germany

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122 Thought-mapping and structured stories as an HIV/AIDS risk reduction approach for Brazilian cocaine users F. Pechansky F. Kessler, L. Von Diemen, E. Silva, H. Surratt, J. Inciardi, C. Leukefeld and S. Martin, Federal University of Rio Grande do Sul, Porto Alegre, Brazil, University of Delaware, Coral Gables, FL and University of Kentucky, Lexington, KY 123 Differential effects of heroin, cocaine, and other drugs on neuropsychological executive functions: Implications for HIV risk W.W. Latimer, S.G. Severtson, L.J. Floyd, A.G. Moleko and A.L. Lawson, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD and University of Pretoria, South Africa 124 Are “standard” interventions actually effective in reducing HIV risk among chronic drug users? C.B. McCoy, L.R. Metsch, Y. Jeanty and M. Comerford, University of Miami, Miami, FL OPIOID TREATMENT: BUPRENORPHINE AND NALTREXONE 125 30-day outcomes for buprenorphine patients treated by a national sample of qualified physicians: Findings from CSAT’s Evaluation of the Buprenorphine Waiver Program C.C. McLeod, W. Kissin, A. Stanton and J. Sonnefeld, Westat and Center for Substance Abuse Treatment, Rockville, MD 126 A controlled trial of depot naltrexone combined with behavioral naltrexone therapy vs. compliance enhancement: Preliminary findings M.A. Sullivan, L.M. Curtiss, J.L. Rothenberg, K. Carpenter and E.V. Nunes, Columbia University College of Physicians and Surgeons/New York State Psychiatric Institute, New York, NY 127 Predictors of outcome in the NIDA Clinical Trials Network randomized, multicenter trial of buprenorphine-naloxone versus for short-term medically supervised withdrawal D. Ziedonis, L. Amass, M. Steinberg, G. Woody, J. Krejci and W. Ling, Robert Wood Johnson Medical School, Piscataway, NJ, University of Pennsylvania, Philadelphia, PA, Friends Research Institute, and University of California, Los Angeles, CA 128 Workload and technical comparisons of naltrexone tablet-, naltrexone implant- and buprenorphine- mediated opiate detoxification A.S. Reece, Southcity Medical Centre, Brisbane, Australia 129 Reducing hospital presentations for in patients treated with sustained-release naltrexone implants G.K. Hulse, R. Tait, S.D. Comer, M.A. Sullivan and D. Arnold-Reed, University of Western Australia, Perth, Australia and Columbia University, New York, NY 130 Long-term management of opiate-dependent patients with naltrexone G. O’Neil, University of Western Australia, Perth, Australia 131 Office-based treatment of opioid dependence with buprenorphine/naloxone sublingual tablets: Results from a multicenter study P. Fudala, R. Walsh, W. Ling, P. Casadonte, F. McSherry W. Williford, J. Collins, D. Raisch, S. Kilby, A. Saxon, B. Johnson, P. Ordorica, U. Malkerneker and A. Elkashef, VA Medical Centers (Various), NIDA, Bethesda, MD, University of California, Los Angeles, CA VACSP Data Coordinating Center and VACSP Pharmacy Coordinating Center, Albuquerque, NM 132 Patient satisfaction with primary care office-based buprenorphine treatment D.T. Barry, D.A. Fiellin, B.A. Moore and R.S. Schottenfeld, Yale University School of Medicine, New Haven, CT

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133 Treating homeless opioid-dependent patients with buprenorphine in an office-based setting C.T. LaBelle, D.P. Alford, J.M. Richardson, J.J. O’Connell, C.A. Hohl, D.M. Cheng, and J.H. Samet, Boston Medical Center, Boston Public Health Commission, Boston University Schools of Medicine, Public Health and Boston Health Care for the Homeless Program, Boston, MA 134 Counseling and attendance requirements for buprenorphine treatment in primary care D.A. Fiellin, M.V. Pantalon, M.C. Chawarski, L.E. Sullivan, B.A. Moore, D. Barry, P.G. O’Connor and R.S. Schottenfeld, Yale University School of Medicine, New Haven, CT 135 Buprenorphine induction: An algorithm W. Ling, M. Torrington, M. Keating, J. Fradis and J.C. Rathner, University of California and The Friends Research Institute, Los Angeles, CA TREATMENT FOR POLYDRUG ABUSE 136 Training community mental health clinicians in a motivational intervention for co-occurring disorders: Effects on clinician in-session behavior C.L. Madeja, E.P. Schoener, M.J. Henderson, S.J. Ondersma and J.J. Janisse, Wayne State University, Detroit, MI 137 Increasing substance abuse education among generalists: The Chief Resident Immersion Training program D.P. Alford, M.A. Amodeo, J. Ashba and J.H. Samet, Boston University School of Medicine and Boston Medical Center, Boston University School of Social Work and Boston University, Boston, MA 138 Learning interests and needs of community clinicians E.P. Schoener, C.L. Arfken and S.A. Ball, Wayne State University, Detroit, MI and Yale University, New Haven, CT 139 Counselors of the Clinical Trials Network B.E. Fuller, E. Edmundson and D. McCarty, Oregon Health and Science University, Portland, OR 140 Availability and content of formal clinical supervision programs in the CTN L.J. Ducharme, J.A. Johnson, H.K. Knudsen and P.M. Roman, University of Georgia, Athens, GA 141 Empirically supported substance abuse treatment approaches: A survey of treatment providers’ perspectives and practices D.M. Herbeck, Y. Hser and C. Teruya, University of California, Los Angeles, CA 142 Improving alcoholism counselors knowledge about the sexual risk behavior of their clients S.B. Berns and D.A. Calsyn, University of Washington, Seattle, WA 143 And they’re off………racing to recruit subjects in clinical trials of substance abuse treatment H. Cronin, D. Svikis, L. Keyser-Marcus, T. Rieckman, S. Coan and M. Stitzer, Johns Hopkins University School of Medicine, Baltimore, MD, Virginia Commonwealth University, Richmond, VA and Oregon Health Sciences, Portland, OR 144 Factors associated with high readiness to change substance use behaviors among hospitalized adults R.A. Pollini, T.P. O’Toole, D. Ford and G. Bigelow, Johns Hopkins University, Baltimore, MD and Georgetown University School of Medicine, Washington, DC

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145 Perceived treatment helpfulness at discharge and overall and primary long-term drug use improvements at follow-up Z. Zhang, D. Gerstein and P. Friedmann, NORC at the University of Chicago, Washington Office, Washington, DC and Brown Medical School and Rhode Island Hospital, Providence, RI 146 Impact on long-term treatment outcomes of increased treatment engagement by Role Induction E.C. Katz, S.D. King, R. Schwartz, E. Weintraub, W. Barksdale, R. Robinson and B.S. Brown, Friends Research Institute, Inc., University of Maryland School of Medicine, Baltimore, MD and University of North Carolina, Wilmington, NC 147 Patient feedback: A quality improvement system for outpatient clinics O. Kaynak, R.F. Forman, J. Rotrosen, M. Chu, A. Mathis, T. Clodfelter, F. Ingram, J. Sharpe Potter, P. Muchowski, K. Magruder, A. Chellis, K. Brower and S. Strobbe, National Drug Abuse Clinical Trials Network, Bethesda, MD 148 Towards an integrated predictive model of 12-step affiliation K. Morgen, A. Laudet, V. Stanick, J. Carway and B. Sand, National Development and Research Institutes, Inc., VIP Community Services, and Woodhull Medical Center, New York, NY 149 The role of therapeutic alliance in alcohol and drug abuse treatment outcome D.A. Bux, Jr., J. Morgenstern, E. Labouvie, T. Morgan and K. Blanchard, Columbia University and Columbia University College of Physicians and Surgeons, New York, NY and Rutgers University, New Brunswick, NJ 150 Motivationally enhanced group counseling for substance users in a soup kitchen: A randomized clinical trial D. Kayman, S. Magura, A. Rosenblum, C. Gordon and C. Fong, National Development and Research Institutes, Inc., New York, NY 151 Organizational characteristics of treatment programs and client outcomes J.C. Yang, C. Teruya, D. Huang and Y.I. Hser, University of California, Los Angeles, CA 152 Measuring therapeutic community substance abuse treatment process and its relation to outcomes M. Orlando, S. Wenzel, S. Paddock, W. Mandell, P. Ebener, J. Dahl and L. Damesek, RAND, Santa Monica, CA and Phoenix House, New York, NY 153 Change in social networks after addictions treatment and relation to treatment outcome J. Morgenstern, D.A. Bux, E. Labouvie, T. Morgan and K. Blanchard, Columbia University School of Physicians and Surgeons and Columbia University, New York, NY and Rutgers University, New Brunswick, NJ 154 Predictors of sustained recovery by recovery stage among former poly-substance users A.B. Laudet, W.L. White and K. Morgen, National Development and Research Institutes, Inc., New York, NY and Chestnut Health Systems, Bloomington, IL 155 Preliminary findings from the second early re-intervention experiment with Recovery Management Checkups C.K. Scott, M.L. Dennis, R.R. Funk, Chestnut Health Systems, Chicago and Bloomington, IL 156 Child welfare costs at four-year followup for mothers attending women-only versus mixed- gender long-term residential treatment W.B. Kissin, R.G. Orwin, R. Claus, K. Campbell, C.E. Grella, T.J. Williams, A. Krupski and S. Green, Westat, Rockville, MD, University of Missouri, St. Louis, MO, Washington Div. of Alcohol and Substance Abuse, Olympia, WA and University of California, Los Angeles, CA

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157 Racial disparities and time-to-drug-treatment entry I. Kuo, H.S. Reisinger and H.D. Chilcoat, Johns Hopkins School of Public Health, Baltimore, MD 158 Substance use patterns among Mexican Americans by generation in the U.S. R.T. Spence and L.S. Wallisch, University of Texas School of Social Work, Austin, TX 159 Causal predominance in the use of cocaine and alcohol K.A. McQueen, C.E. Green, S. Sayre, M. Mooney and J. Schmitz, University of Texas Health Science Center and Baylor College of Medicine, Houston, TX Symposium X Crown Hall 10:00 AM -12:00 PM CANNABINOIDS DURING DEVELOPMENT: FROM THE LAB TO THE CLINIC

Chairs: Sari Izenwasser and Diana Dow-Edwards 10:00 Prenatal exposure to marijuana and : Long-term effects of prenatal marijuana exposure on cognitive functioning Peter Fried, Carleton University, Ottawa, Canada 10:25 Effects of prenatal cannabinoids on several key genes for neurotransmitter function Julian Romero and Javier Fernandez-Ruiz, Fundacion Hospital Alcorcon and Universidad Complutense de Madrid, Spain 10:50 Cannabinoid interactions with psychostimulants in adolescent vs. adult rats: Is there a gateway during adolescence? Sari Izenwasser, University of Miami School of Medicine, Miami, FL 11:15 Reducing adolescent cannabis use and co-occurring problems through family-based treatment Cynthia L. Rowe, University of Miami School of Medicine, Miami, FL 11:40 Marijuana and development: Summary of clinical and preclinical effects Discussant: Diana Dow-Edwards, State University of New York, Brooklyn, NY Oral Communications XV Scotland 10:00 AM - 12:00 PM COGNITION: IT'S THE THOUGHT THAT COUNTS

Chairs: Paulo J. Cunha and Sara L. Simon 10:00 Long-term effects of cannabis use on cognitive brain function G. Jager, J.M. van Ree, R.S. Kahn, M.M. de Wit, W. van den Brink and N.F. Ramsey, University Medical Center Utrecht, and Academic Medical Center of the University of Amsterdam, 10:15 Cognitive failure in cannabis and club drug users in comparision to non-users in a population- based sample U. Kandler, M. Piechatzek, F. Indlekofer, R. Lieb, H.U. Wittchen and C.G. Schuetz, Max Planck Institute, Ludwig-Maximilians Universitat, Munich, Technische Universitat, Dresden, and Friedrich-Wilhelms-University, Bonn, Germany 10:30 Effects of combined use of tobacco and cannabis on verbal memory in adolescents L.K. Jacobsen, W.E. Mencl, K.R. Pugh and M. Westerveld, Yale University School of Medicine, New Haven, CT

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10:45 Acute methamphetamine exposure worsens neurocognitive functioning A.D. Kalechstein, T.F. Newton and R. de la Garza, II, University of California, Los Angeles, CA 11:00 Cognition in abstinent methamphetamine abusers: A cross-sectional study S.L. Simon, J. Dacey, R.A. Rawson and W. Ling, University of California, Los Angeles, CA 11:15 Decision-making impairments associated with ADHD symptoms in cocaine abusers P.J. Cunha and S. Nicastri, University of Sao Paulo, Brazil and Hospital Israelita Albert Einstein, Sao Paulo, Brazil 11:30 Ecstasy (3,4-methylenedioxymethamphetamine) abuse: Relationships between cognitive performance and cerebral blood-flow measures C.M. Schroder, N.M. Wilson, K. Tate, W. Better, R. Herning, K. Bolla and J.L. Cadet, NIH/NIDA Intramural Research Program, and Johns Hopkins School of Medicine, Baltimore, MD 11:45 Cognitive function and mood symptoms in light and heavy MDMA users who abuse cannabis L.H. Lundahl, C. Aubie, K. Berardi, C.E. Johanson and M. Tancer, Wayne State University School of Medicine, Detroit, MI Oral Communications XVI Ireland 10:00 AM - 12:00 PM MICKEY VS MINNIE: SEX DIFFERENCES AND DRUGS OF ABUSE

Chairs: Rajeev Ramchand and Marc E. Mooney 10:00 Gender differences in acute tobacco withdrawal A.M. Leventhal, A.J. Waters, W. Pickworth, N. Eid, S. Boyd, E.T. Moolchan and C. Lerman, University of Texas M.D. Anderson Cancer Center, Houston, TX, NIH/NIDA Intramural Research Program, Baltimore, MD and University of Pennsylvania, Philadelphia, PA 10:15 Evidence for gender differences in cue reactivity to in vivo smoking cues in nicotine-dependent smokers S.D. LaRowe, H.P. Upadhyaya, M.E. Saladin, M.J. Carpenter and K.T. Brady, Medical University of South Carolina, Charleston, SC 10:30 Environmental enrichment affects nicotine’s activity stimulating actions in males and females differently A.B. Myracle, S.S. Shafer, B.M. Elliott and N.E. Grunberg, Uniformed Services University of the Health Sciences, Bethesda, MD 10:45 Relationship between quit length, cue-responsiveness and craving in former smokers: A gender analysis M. Mahabir, L. Zawertailo, M. Zack, P. Selby and U. Busto, University of Toronto, Toronto, Canada 11:00 Sex differences in the linkage between adolescent work experience and alcohol, tobacco, and marijuana use in an urban environment R. Ramchand, N.S. Ialongo and H.D. Chilcoat, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 11:15 Gender and impulsivity in cocaine-dependence treatment outcomes: A multistudy analysis M. Mooney, C. Green, F.G. Moeller, H. Rhoades, J. Grabowski and J. Schmitz, University of Texas-Houston, Houston, TX

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11:30 Gender differences in cocaine relapse with high-dose naltrexone J.J. Suh, H.M. Pettinati and K.M. Kampman, University of Pennsylvania, Philadelphia, PA 11:45 Short-duration cocaine administration induces time-dependent changes during withdrawal: An investigation of gender differences G. Pereira Do Carmo, N.L. Sparkman, R. Kohman, G.R. King and G.W. Boehm, McLean Hospital, Harvard Medical School, Belmont, MA, University of Illinois at Urbana- Champaign, IL and Texas Christian University, Fort Worth, TX

Symposium XI England 10:00 - 11:00 AM PHARMACOTHERAPY FOR COCAINE DEPENDENCE: AN UPDATE FROM NIDA/DPMC

Chairs: Ahmed Elkashef and Roberta Kahn 10:00 Cabergoline Phase II efficacy trial for cocaine dependence Steve Shoptaw, University of California, Los Angeles, CA 10:20 Ondansetron dose-ranging study for cocaine dependence John Roache, University of Texas Health Center at San Antonio, San Antonio, TX 10:40 : No effect on cocaine use Discussant: Eugene Somoza, University of Cincinnati, Cincinnati, OH

Symposium XII England 11:30 AM - 12:30 PM COMBINATIONS OF MEDICATIONS FOR THE TREATMENT OF DRUG ADDICTION

Chairs: Kyle Kampman and Helen Pettinati 11:30 The efficacy of augmented with in cocaine-dependent patients with depressive symptoms Alison Oliveto, University of Arkansas for Medical Sciences, Little Rock, AR 11:50 The combination of naltrexone and disulfiram for the treatment of cocaine and alcohol dependence Helen Pettinati, University of Pennsylvania School of Medicine, Philadelphia, PA 12:10 The combination of and propranolol for the treatment of cocaine-dependent patients with severe cocaine withdrawal symptoms Kyle M. Kampman, University of Pennsylvania School of Medicine and The Philadelphia VA Medical Center, University of Pennsylvania Treatment Research Center, Philadelphia, PA

60 Wednesday, June 22, 2005

Animals in Research Forum Cloister (Bring your lunch) 12:30 - 2:00 PM

Chair: Nancy K. Mello

Animal research: In the court of law and the court of public opinion Guest Speaker: Frankie Trull, President, Foundation for Biomedical Research and The National Association for Biomedical Research

Symposium XIII England 2:00 - 4:00 PM TO TREAT OR NOT TO TREAT, IS THAT THE QUESTION?: INTERNATIONAL PERSPECTIVES ON NEONATAL ABSTINENCE SYNDROME ASSESSMENT AND TREATMENT

Chairs: Loretta P. Finnegan and Hendree Jones 2:00 Perspectives in the treatment of neonatal abstinence in Vienna, Austria Gabriele Fischer, Medical University of Vienna, Vienna, Austria 2:25 Various solutions for the treatment of NAS in the United States Karol Kaltenbach, Thomas Jefferson University, Philadelphia, PA 2:50 Neonatal withdrawal in the Antipodes: Management of NAS in Australia Adrian Dunlop, Turning Point Alcohol and Drug Centre, Fitzroy, Australia 3:15 Maternal methadone dose and length of stay for NAS in a Canadian hospital Peter Selby, University of Toronto, Canada 3:40 Comparison of methods utilized around the world for the assessment and treatment of neonatal abstinence syndrome Discussant: Loretta P. Finnegan, Office of Research on Women’s Health, NIH, Bethesda, MD

Symposium XIV Ireland 2:00 - 4:00 PM PHARMACOGENETICS AND DRUG ABUSE

Chairs: Joni Rutter and David Shurtleff 2:00 Pharmacogenetics of MDMA: From animal models to man Rafael de la Torre, Institut Municipal d’Investigacio, Barcelona, Spain 2:25 Pharmacogenetic analyses of initial sensitivity and neuroadaption to alcohol Tamara J. Phillips, Oregon Health and Science University, Portland, OR 2:50 Multiple effects of a functional mu opioid receptor gene polymorphism Wade H. Berrettini, University of Pennsylvania, Philadelphia, PA

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3:15 Pharmacogenetic approach to nicotine dependence and treatment Caryn E. Lerman, University of Pennsylvania, Philadelphia, PA 3:40 Discussant Joni L. Rutter, Genetics and Molecular Neurobiology Research Branch, NIH, Bethesda, MD

Oral Communications XVII Scotland 2:00 - 3:45 PM OPIOID BEHAVIOR

Chairs: F. Ivy Carroll and Galen R. Wenger 2:00 Morphine-induced lowering of the brain-stimulation reward threshold in mice determined by the rate-independent psychophysical method C. Knapp, S. Crosby and C. Kornetsky, Boston University School of Medicine, Boston, MA 2:15 Opioid drug discrimination in C57BL/6J, DBA/2J and 129/SvImJ mice G.R. Wenger, University of Arkansas for Medical Science, Little Rock, AR 2:30 Interactions between mu and kappa opioid agonists in assays of schedule-controlled responding and thermal nociception in rhesus monkeys: A dose-addition analysis G.W. Stevenson, S.B. McWilliams and S.S. Negus, McLean Hospital, Harvard Medical School, Belmont, MA 2:45 The kappa opioid receptor-selective antagonist JDTic is active in the forced-swim test in rats F.I. Carroll, G.T. Pollard and J.L. Howard, Research Triangle Institute, Research Triangle Park, NC and Howard Assoc., LLC, Research Triangle Park, NC 3:00 Ultra-low-dose naltrexone attenuates the rewarding potency of oxycodone and decreases vulnerability to relapse in rats L. Burns and F. Leri, Pain Therapeutics Inc., South San Francisco, CA and University of Guelph, Guelph, Canada 3:15 The selective delta opioid antagonist potentiates a morphine-induced conditioned taste aversion M.A. Fox and A.L. Riley, American University, Washington, DC 3:30 Potentiation of learning disruption by combinations of morphine and NMDA antagonist LY235959 L.L. Miller, A.P. McKinney, J.P. Wagner and M. Galizio, University of North Carolina, Wilmington, NC 3:45 Introduction J.P. McLaughlin, J.E. Pintar and C.C. Chavkin, Northeastern University, Boston, MA, University of Medicine and Dentistry-NJ, Robert Wood Johnson Medical School, Piscataway, NJ and University of Washington, Seattle, WA

BADGES MUST BE WORN IN ALL SCIENTIFIC SESSIONS

62 Wednesday, June 22, 2005

Oral Communications XVIII Crown Hall 2:00 - 3:00 PM CANNABINOIDS: MECHANISMS OF ACTION

Chairs: Dana E. Selley and Sara J. Ward 2:00 Chronic delta-9- treatment produces antinociceptive tolerance in mice without altering protein kinase A activity in mouse brain G.D. Dalton, F.L. Smith and W.L. Dewey, Virginia Commonwealth University, Richmond, VA 2:15 Relative efficacy of standard cannabinoids and novel CB2-selective analogs to activate CB2 receptors D.E. Selley, M.P. Cassidy, W.K. Rorrer, Q. Tao, A. Mahadevan, M.E. Abood, R.K. Razdan and B.R. Martin, Virginia Commonwealth University, Richmond, VA, Organix, Inc., Woburn, MA and California Pacific Medical Center, San Francisco, CA 2:30 CB1 knockout mice show reduced sensitivity to the reinforcing effects of a high-carbohydrate drink but not to vegetable oil under the progressive-ratio procedure S.J. Ward and L.A. Dykstra, University of North Carolina at Chapel Hill, Chapel Hill, NC 2:45 Behavioral and physiologic interactions between Δ9-tetrahydrocannabinol and dopamine D2-like receptor ligands in rhesus monkeys M.R. Amin, C.P. France and L.R. McMahon, University of Texas Health Science Center, San Antonio, TX

Oral Communications XIX Crown Hall 3:30 - 4:30 PM SPACEY MOUNTAIN: CLUB DRUG HIGHS

Chairs: Lawrence P. Carter and Michelle R. Lofwall 3:30 Abuse liability and comparative pharmacology of GHB, triazolam and in sedative drug abusers B.D. Richards and R.R. Griffiths, Johns Hopkins University School of Medicine, Baltimore, MD 3:45 Lack of behavioral effects following icv administration of GBL and 1,4-BDL in rats L.P. Carter, M.A. Hague, W. Koek and C.P. France, University of Texas Health Science Center at San Antonio, San Antonio, TX 4:00 Neurocognitive and subjective acute dose-effects of intramuscular in healthy non-drug abusing adults M.R. Lofwall, R.R. Griffiths and M.Z. Mintzer, Johns Hopkins University, Baltimore, MD 4:15 Repeated administrations of gamma-hydroxybutyric acid in adolescent rat: Effects on spatial learning and memory and the NMDA receptor R. Sircar and A.K. Basak, The Zucker Hillside Hospital, Glen Oaks, NY

63 Wednesday, June 22, 2005

BUSINESS MEETING England (Members Only) 4:45 - 6:00 PM

Dinner and Dancing Great Hall 7:30 - 10:30 PM

Thursday, June 23, 2005

POSTER SESSION IV (Breakfast) Exhibition Hall 7:30 - 9:30 AM Odd-numbered posters manned first hour; Even-numbered, second hour

Set-up time begins Wednesday 1:00 P.M. Must be removed by Thursday 12:30 P.M. HIV/AIDS, HEPATITIS C 1 Experts outline ways to change the decade-long yearly rate of 40,000 new HIV infections in the U.S. J. Fisher and M. Copenhaver, University of Connecticut, Storrs, CT 2 Comparing HIV and HCV-related stigma among clients in drug treatment programs J.M. Astone-Twerell, S.M. Strauss, C. Munoz-Plaza, H. Hagan and D.C. Des Jarlais, National Development and Research Institutes, Inc., New York, and Beth Israel Medical Center, New York, NY 3 Highlighting hepatitis C services at drug treatment programs: Identifying sources of innovation C. Munoz-Plaza, S. Strauss, J. Astone, D. Des Jarlais and H. Hagan, National Development and Research Institutes, Inc., New York, and Beth Israel Medical Center, New York, NY 4 The influence of recovering staff with hepatitis C virus (HCV) infection on the provision of HCV services in drug treatment programs S.M. Strauss, J.M. Astone-Twerell, H. Hagan and D.C. Des Jarlais, National Development and Research Institutes, Inc., New York, and Beth Israel Medical Center, New York, NY 5 HBV vaccination among injection drug users in New York City: Missed opportunities for intervention D.C. Ompad, C.M. Fuller, C.A. Chan, D. Vlahov and S. Galea, New York Academy of Medicine, and Columbia University, New York, NY 6 Stabilizing syringe exchange-recruited heroin users toward hepatitis C treatment using buprenorphine D.L. Sylvestre, T.M. Nardine, E. Zubritsky and J.B. Cohen, O.A.S.I.S., Oakland, University of California, San Francisco, and East Bay Community Recovery Project, San Francisco, CA

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7 Perceptions and preferences regarding HCV treatment among HCV-infected injection drug users in three U.S. cities E.T. Golub, H. Hagan, M. Latka, R.A. Pollini, J.V. Campbell, M. Coady, and S.A. Strathdee, Johns Hopkins University, Baltimore, MD, NDRI, Inc., New York Academy of Medicine, New York, NY, Public Health Seattle-King County, Seattle, WA and UCSD, CA 8 Hepatitis C among homeless adults in Los Angeles L. Gelberg, M. Robertson, L. Arangua, R.M. Andersen, H. Morgenstern and B.D. Leake, University of California, Los Angeles, CA and University of Michigan, Ann Arbor, MI 9 Hepatitis C and HIV risk among participants in medication trials for methamphetamine dependence T. Freese, R. Rawson, V. Pearce, I. Diaz, A. Elkashef, E. Smith and Other MCTG Investigators, University of California, Los Angeles, CA, NIDA, Bethesda, MD and Five MCTG Research Sites 10 Interest of the FibroScan in a toxicology consultation: Preliminary Results L. Gouarier, P. Melin and J.P. Lang, Hospital European Georges Pompidou, Paris, Saint Dizier Hospital, Saint Dizier, and Strasbourg Hospital, Strasbourg, France 11 Alcohol use among HIV-positive individuals: The impact of gender, personality, and drug dependence C.J. Heckman, K.S. Ingersoll, J. Cohen and A. Walker, Virginia Commonwealth University, Richmond, VA 12 Comorbidity of addictions, alcoholism and infectious diseases in St. Petersburg, Russia E.M. Krupitsky, E.E. Zvartau, D.A. Lioznov, M.V. Tsoy, V.Y. Egorova, Y.A. Zorina, T.V. Belyaeva, T.V. Antonova, N.A. Brazhenko, Z.M. Zagdyn and G.E. Woody, Leningrad Regional Center of Addictions, St. Petersburg, St. Petersburg State Pavlov Medical University, St. Petersburg, Russia and University of Pennsylvania, Philadelphia, PA 13 Characteristics of injecting drug users in three cities in Russia: Baseline findings of a cohort study to evaluate harm reduction/needle exchange programs K. Eroshina, A. Bobrik, N. Vasilieva and Y. Neumark, Open Health Institute, Moscow, Russia and Hebrew University-Hadassah, Jerusalem, Israel 14 Treatment response and clinical correlates of IDU and HIV among heroin addicts in Malaysia M.C. Chawarski, M. Mazlan and R.S. Schottenfeld, Yale University School of Medicine, New Haven, CT and Substance Abuse Center, Muar, Malaysia 15 HIV risk and treatment entry among drug users in Rio de Janeiro, Brazil: Geo-behavioral analyses A.A. Simoes, F.I. Bastos, R.I. Moreira, C. Barbosa, W.B. Azevedo, M. Magalhaes, A. Hillier and D.S. Metzger, Health Department of Rio de Janeiro State, and Oswaldo Cruz Foundation, Rio de Janeiro, Brazil and University of Pennsylvania, Philadelphia, PA 16 Frequency of psychopathology among people living with HIV/AIDS with risk factors of injecting drug user and unsafe sex A.Wibowo, S.Wibisono, The Drug Dependence Hospital, Jakarta, Indonesia 17 Factors associated with drug and sexual risk among 1733 injection drug users in Philadelphia M.S. Eisenberg, A.D. Vogel, M. Lanier, D. Fiore, G. Fields, J. Myers and D.S. Metzger, University of Pennsylvania, Philadelphia, PA

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18 A comparison of drug-use patterns and HIV/STD prevalence among female sex workers in two Mexican-U.S. border cities T.L. Patterson, S.J. Semple, J. Bucardo, A. DeLaTorre, M. Fraga, H. Staines Orozco, J. Salazar Reyna, H. Amaro, C. Magis, S.A. Strathdee, UCSD, La Jolla, UCLA, Los Angeles, CA, Universidad Autonoma de Baja-CA, U. Autonoma de Ciudad Juarez, and CENSIDA, Mexico, U. Autonoma de Tamaulipas, Northeastern University of Boston, MA 19 Sexually transmitted diseases in poor female crack users of Porto Alegre, Brazil F.H. Kessler, F. Pechansky, L. Von Diemen, J. Inciardi, and H. Surratt, Federal University of Rio Grande, Porto Alegre, Brazil LITERATURE REVIEW 20 Key components in HIV prevention interventions targeting IDUs: A meta-analysis M.M. Copenhaver, J.J. Harman, I. Lee, B.T. Johnson and M.P. Carey, University of Connecticut, Storrs, CT and Syracuse University, Syracuse, NY 21 Project synthesis: A review of reviews of best practices of drug prevention K.C. Winters and T. Fawkes, University of Minnesota, Minneapolis, MN 22 Comprehensive self-administration research-oriented reference database online V.L. Tsibulsky and A.B. Norman, University of Cincinnati College of Medicine, Cincinnati, OH 23 Gender and the substance abuse treatment workforce: Implications for the field N.A. Roget, S.A. Storti, E.C. Albers, P.K. Horvatich and A.H. Skinstad, University of Nevada, Reno, NV, Brown University, Providence, RI, Virginia Commonwealth University, Richmond, VA and University of Iowa, Iowa City, IA 24 Economic evaluation of substance abuse treatment N.S. Patapis and S. Belenko, Treatment Research Institute, Philadelphia, PA 25 Marijuana effects on automobile driving: Recent research and future directions A. Liguori, Wake Forest University School of Medicine, Winston-Salem, NC PROGRAM DESCRIPTION 26 Senior alcohol abuse: Programs for older adults and healthcare providers K. Munly, L. Hess, S. Nemes, L. Pelletier, M. Landry, E. Moolchan, Danya International, Inc., Silver Spring, and NIH/NIDA Intramural Research Program, Bethesda, MD 27 Training technology to enhance addiction counselor training (TEACH-CBT) M.J. Larson, M.A. Amodeo, S. Storti, S. Carolan and L. Smith, New England Research Institutes, Watertown, Boston University Boston, MA and Brown University, Providence, RI 28 Translating the GAIN instruments for use in Spanish-speaking populations J.C. Titus, L.E. Flores, L. Bedoya, L. Jiménez, D.P. Esquivel and M. Blair, Chestnut Health Systems, Bloomington, IL, SCAN, Laredo, TX, Harlem Hospital Center, New York, and Research Foundation for Mental Hygiene, Albany, NY 29 Enhancing treatment outcomes and patient-staff satisfaction using a web-based patient feedback performance improvement system R.E. Sage, M. Chu, R. King, R. Sumpter, A. Kulaga, L.S. Brown and R. Forman, Addiction Research and Treatment Corporation, Brooklyn, New York University Medical Center, New York, NY and University of Pennsylvania, Philadelphia, PA 30 Men (and women) at work: Success stories of the Job Seekers’ Workshop T. Rieckmann, L. Keyser-Marcus, S. Back, C. Wong, P. Loeb, T. Allen and D. Svikis, Oregon Health Sciences University, Portland, OR, Virginia Commonwealth University, Richmond, VA, Medical University of South Carolina, Charleston, SC, Johns Hopkins University, Baltimore, MD and Allen & Loeb Assoc., San Francisco, CA 66 Thursday, June 23, 2005

31 Creating a spiritual community that reinforces drug abstinence: Preliminary report M.L. Kerwin, K. Walker-Smith, R.A. Corbin, T.M. Faranda-Diedrich, J. Menarde and K.C. Kirby, Rowan University, Glassboro, NJ, Treatment Research Institute and University of Pennsylvania School of Medicine, Philadelphia, PA 32 The LET (Life Experience Timeline): A new instrument for collecting time-anchored natural history data M.P. Hillhouse, P. Marinelli-Casey and R. Rawson, University of California, Los Angeles, CA 33 Development of the Behavioral Health Screening and Assessment Package S.V. Libretto, L. Hess, N. Linder, M. Hile and E. Moolchan, Danya International, Inc., Silver Spring, MD, Missouri Institute of Mental Health, St. Louis, MO and NIH/NIDA Intramural Research Program, Baltimore, MD 34 Methadone maintenance for heroin users with serious mental illness D.H. Gandhi, E.C. Katz, J.H. Jaffe, E. Weintraub and J. Benford, University of Maryland School of Medicine, and Friends Research Institute, Inc., Baltimore, MD 35 Challenges to implementing a 12-step group for dually diagnosed outpatients A. Rosenblum, C.L. Villano, S. Magura, A. Laudet, H. Vogel and T. Betzler, National Development and Research Institutes, Inc., New York, Double Trouble in Recovery, Inc., Brooklyn, and Albert Einstein College of Medicine, Bronx, NY 36 Predictors of chronic severe pain among dually diagnosed outpatients C.L. Villano, A. Rosenblum, S. Magura, C. Fong and T. Betzler, National Development and Research Institutes, Inc., New York, and Albert Einstein College of Medicine, Bronx, NY 37 Characteristics of screening, evaluation, and treatment of HIV/AIDS, hepatitis C viral infection, and sexually transmitted infections in substance abuse treatment programs L.S. Brown, S. Kritz, J. Rotrosen, J. Goldsmith and J. Robinson, Addiction Research and Treatment Corporation, Brooklyn, New York University Medical Center, New York, NY, University of Cincinnati Medical Center Cincinnati, OH and Nathan Kline Institute, Orangeburg, NY 38 Effectiveness of an engagement and embeddedness model to reduce HIV risk behaviors among Hispanic drug-using women R.R. Robles, T.D. Matos, E.I. Quiñones, I. Carrión and C.R. Rodríguez, Universidad Central del Caribe, School of Medicine, Bayamon, PR 39 Substance use and HIV prevention for incarcerated minority adolescents D.W. Watson and W.J. Mcculler, University of California, and Friends Research Institute, Los Angeles, CA 40 Addressing the needs of adolescents with substance abuse and mental health disorders at The Bridge Residential Treatment Program: A case study in organizational change L. Hurtig and J. Benitez, Philadelphia Health Management Corporation, Philadelphia, PA 41 Program of early detection of children at risk among school population of Voronezh (Russia) B. Lobodov and O. Stepanenco, The Center of Treatment and Prevention of Drug Related Disorders, Voronezh, Russia 42 StartSMART: Development and evaluation of full-scale school-based tobacco prevention program J. Weil, S. Zack, S. Nemes, J. Hoffman, K. Munly, J. Melendez and E. Moolchan, Danya International, Inc., Silver Spring, and NIH/NIDA Intramural Research Program, Baltimore, MD

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43 Establishing a statewide research coalition to address the causes and prevention of youth tobacco use J.R. Koch, R.L. Balster, E.E. Dowdy, S.L. Hart and R.W. Pickens, Virginia Commonwealth University, Richmond, VA 44 Behavior disorder among street youth exposed and not exposed to inhalant I.K. Kirtadze and D.Z. Zurabashvili, State Medical Academy and M. Asatiani Research Institute of Psychiatry, Tbilisi, Georgia 45 Current drug scheduling reviews reported by the Drug Enforcement Administration S.R. Tella, J.M. Tolliver, G.K. Feussner, B.A. Hayes, S.M. Carr and C.A. Sannerud, Office of Diversion Control, Drug Enforcement Administration, Washington, DC CRIMINAL JUSTICE 46 Substance abuse treatment at the front end of the criminal justice continuum: Analysis of NSDUH 2002 S.P. Kubiak and C.L. Arfken, Wayne State University, Detroit, MI 47 A history of juvenile justice involvement is associated with higher lifetime substance abuse among female adult inmates G.C. Villalobos, K.L. Cropsey, M.F. Weaver and M.L. Stitzer, Virginia Commonwealth University, Richmond, VA and Johns Hopkins University, Baltimore, MD 48 Drug use differences by race in women prisoners M.F. Weaver, G.C. Villalobos, and K.L. Cropsey, Virginia Commonwealth University, Richmond, VA 49 Trauma histories among California women inmates N.P. Messina, M.L. Prendergast and W. Burdon, University of California, Los Angeles, CA 50 Social network as a moderator of gender differences in employment among drug court participants M. Staton Tindall, J.L. Duvall, C.G. Leukefeld, J.M. Webster and T.F. Garrity, University of Kentucky, Lexington, KY 51 Clients’ perceptions of the severity of drug court consequences P.A. Lee, G. Fox, D.B. Marlowe, D.S. Festinger and A.T. McLellan, Treatment Research Institute, Philadelphia, PA 52 Correlates of treatment utilization among rural and urban probationers C.B. Oser, J.R. Havens, C.G. Leukefeld, J.M. Webster, S.S. Martin, G.J. Postle, D.J. O’Connell, J.A. Inciardi and H.L. Surratt, University of Kentucky, Lexington, KY and University of Delaware, Newark, DE 53 Short-term effects of motivational enhancement therapy with drug court probationers T.W. Kinlock, E.A. Sears, B.S. Brown, K. O’Grady and J.M. Callaman, Friends Research Institute, Inc., Baltimore, MD 54 Judicial supervision and contingency management in treating drug-abusing offenders: Preliminary outcomes M.L. Prendergast, E.A. Hall and J.M. Roll, University of California, Los Angeles, CA, Washington State University at Spokane, WA and Friends Research Institute, Los Angeles, CA

54.5

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55 Differential predictors of return-to-custody among male and female parolees from prison-based therapeutic community substance abuse programs W.M. Burdon, N.P. Messina and M.L. Prendergast, University of California, Los Angeles, CA 56 Role of judicial status hearings in drug court: 24-month criminal recidivism D.S. Festinger, D.B. Marlowe, P.A. Lee and D.S. DeMatteo, Treatment Research Institute, Philadelphia, PA HAIR AND URINE TESTING 57 Designing sensitive abstinence reinforcement procedures based on analyses of changes in urinary benzoylecgonine concentrations in regular cocaine users T.W. Knealing, M. Needham, C.J. Wong and K. Silverman, Johns Hopkins University School of Medicine, Baltimore, MD 58 Correlates of cocaine-positive intake urine screen results H.M. Rhoades, J. Grabowski, J.M. Schmitz and M. Mooney, University of Texas Medical School at Houston, Houston, TX 59 Reliability of quantitative urinalysis testing for cocaine abstinence reinforcement procedures M. Needham, H. Brown, T.W. Knealing, C.J. Wong and K. Silverman, Johns Hopkins University School of Medicine, Baltimore, MD 60 Improving self-reported recency of drug use by means of on-site urine testing M.L. Dennis, M.A. Foss and C.K. Scott, Chestnut Health Systems, Bloomington and Chicago, IL 61 Enzyme immunoassay versus gas chromatogrophy-mass spectrometry in the assessment of quantitative urine cannabinoid levels R.G. Vandrey and A.J. Budney, University of Vermont, Burlington, VT 62 Segmental hair analysis for cocaine and : Determining pattern of use for association with cause of death in victims of suspected drug overdose J.P. Pablo, H. Druid, W.L. Hearn and D.C. Mash, University of Miami School of Medicine, Miami-Dade Medical Examiner, Miami, FL, and Karolinska Institutet, Stockholm, Sweden ADOLESCENTS: MARIJUANA AND NICOTINE USE AND ABUSE 63 Understanding gender differences in drug use by considering drug-exposure opportunities K.M. Green and M.E. Ensminger, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 64 Course of cannabis use, abuse and dependence and service use patterns: Results from a prospective community study A. Perkonigg, P. Zimmermann, C. Fröhlich, R. Lieb and H.U. Wittchen, Technical University of Dresden, Germany and Max Planck Institute of Psychiatry, Munich, Germany 65 Consequences of cannabis use: Effects on psychosocial integration, mental and physical health among young Germans in a prospective-longitudinal investigation P. Zimmermann, H.U. Wittche and R. Lieb, Technical University of Dresden, Dresden, and Max Planck Institute of Psychiatry, Munich, Germany 66 Internalizing disorders as risk factors for subsequent substance use disorders: A prospective- longitudinal community study in adolescents and young adults H.U. Wittchen, C. Fröhlich, P. Zimmermann, R. Lieb and A. Perkonigg, Technical University of Dresden, Clinical Psychology and Psychotherapy, Dresden, and Max Planck Institute of Psychiatry, Munich, Germany

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67 Rates of cannabis abuse and dependence among school-based youth in the U.S., Mexico, and Puerto Rico B.E. Mancha, V.C. Rojas, L.J. Floyd and W.W. Latimer, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 68 The Adolescent Cannabis Check-up G. Martin, J. Copeland, S. Allsop and R. Ali, University of New South Wales, Sydney, Curtin University, Perth and Adelaide University, Adelaide, Australia 69 Effects of drug cue exposure on cue reactivity measured by event-related potential responses to marijuana-related pictures in marijuana-dependent adolescents L.D. Nickerson, J.R. Berko, J.M. Rodolico and S.E. Lukas, McLean Hospital, Belmont, and Harvard Medical School, Boston, MA 70 Relative power and marijuana use within adolescent sexual partnerships P.A. Matson and J.M. Ellen, Johns Hopkins University and Johns Hopkins School of Medicine, Baltimore, MD 71 Does recent marijuana use predict lapse to smoking during adolescent cessation treatment? E.T. Moolchan, M. Jaszyna-Gasior, C.E. Collie, S.J. Heishman and F.H. Franken, NIH/NIDA Intramural Research Program, Baltimore, MD 72 for cannabis withdrawal in depressed adolescents C. Thurstone, P.D. Riggs, H.D. Orton and A.M. Libby, University of Colorado, Denver, CO 73 Depressive symptomatology and craving in adolescents undergoing smoking-cessation treatment K.S. Bagot, F.H. Franken, S.J. Heishman and E.T. Moolchan, NIH/NIDA Intramural Research Program, Baltimore, MD 74 Modafinil and nicotine patch in adolescent and young adult smokers C.A. Martin, T.H. Kelly, G.E. Guenthner, J.C. Cox, S.B. Chapman and H.A. Omar, University of Kentucky College of Medicine, Lexington, KY 75 Nicotine patch therapy for adolescent smokers E.A. Whitmore, A.L. Wold, E.J. Gianani and S.K. Mikulich-Gilbertson, University of Colorado School of Medicine, Denver, CO 76 Effects of cigarette smoking on acute pulmonary function in adolescents M.J. Jaszyna-Gasior, F.H. Franken, C.E. Collie and E.T. Moolchan, NIH/NIDA Intramural Research Program, Baltimore, MD 77 Youthful drug involvement and health-related quality of life in Taiwan C.Y. Chen and C.L. Storr, National Health Research Institutes, Taipei, Taiwan and Johns Hopkins University, Baltimore, MD 78 Leisure boredom and drug involvement among high-school-attending youth Y.C. Wang, C.Y. Chen, C.M. Lee, C.Y. Lew-Ting, C.K. Hsiao, D.R. Chen and W.J. Chen, National Health Research Institutes, National Normal Taiwan University, and National Taiwan University, Taipei, Taiwan 79 Patterns of smoking among tobacco-addicted youth: Real-time assessments from patient electronic diaries F.H. Franken, E.J. Luther and E.T. Moolchan, NIH/NIDA Intramural Research Program, Baltimore, MD

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80 Externalizing symptoms and smoking trajectory among adolescents seeking smoking-cessation treatment: A dimensional analysis M. Frazier, E.T. Moolchan, D. Luckenbaugh, F. Franken, W. Aklin and and M. Ernst, NIH/NIDA Intramural Research Program, Baltimore, MD, University of Maryland, College Park, MD and NIMH, Bethesda, MD 81 Adolescents’ social environment and cigarette smoking: Role of peers and parents E.J. Luther, F.H. Franken and E.T. Moolchan, NIH/NIDA Intramural Research Program, Baltimore, MD 82 Psychosocial and environmental factors that may influence adolescent smoking E.D. Thorner, F. Franken, B. Ladaga and E.T. Moolchan, NIH/NIDA Intramural Research Program, Baltimore, MD 83 Adolescent Escaping Nicotine and Tobacco (ASCENT): Evaluation of a school-based teen tobacco-cessation program S.L. Zack, S. Nemes, J. Hoffman, J. Weil, L. Hess, E. Moolchan, Danya International, Inc., Silver Spring, MD and NIH/NIDA Intramural Research Program, Baltimore, MD NICOTINE - HUMAN STUDIES 84 Menstrual phase effects on psychological motives for smoking A.M. Allen and S.S. Allen, University of Minnesota, Minneapolis, MN 85 Gender and ethnic differences in characteristics of smoking of callers interested in quitting smoking J.L. Mason and D.K. Hatsukami, University of Minnesota, Minneapolis, MN 86 Acculturation, smoking, and nicotine dependence among African American women A.F. Fernander, University of Kentucky, College of Medicine, Lexington, KY 87 Early premalignant predictors in esophagus of patients using tobacco and “Nus” D.K. Tachkuliyeva, O.V. Ponyatov, G.K. Ovezova and H.B. Babayev, Public Center of Health “Victory”, Niyazov Consulting and Treatment Center of Turkmenistan, President Air Force Hospital and Turkmen State Medical Institute, Ashgabat, Turkmenistan 88 Smoking-cessation interventions by physicians and family members: Examination of Chinese American smokers W.J.Y. Cheng and J.Y. Tsoh, University of California, San Francisco, CA 89 The influence of programmed lapses on the relative reinforcing effects of smoking in abstinent smokers L.L. Chivers, A.M. Remillard and S.T. Higgins, University of Vermont, Burlington, VT 90 Smoking-related environments functioning as conditioned stimuli C.A. Conklin, N. Robin and K.A. Perkins, Western Psychiatric Institute and Clinic, Pittsburgh, PA 91 Establishing smoking-abstinence cutoffs using expired carbon monoxide among female prisoners K.L. Cropsey, G.C. Villalobos, M.F. Weaver and M.L. Stitzer, Virginia Commonwealth University, Richmond, VA and Johns Hopkins University, Baltimore, MD 92 Classical and emotional Stroop performance as an indicator of treatment response in opiate- dependent smokers M. Mouratidis, M. Sofuoglu, J. Poling and T.R. Kosten, Yale University School of Medicine, New Haven, and VA Connecticut Healthcare System, West Haven, CT 93 A laboratory analog of voucher reinforcement J. Dallery, B.R. Raiff and J.C. Wilson, University of Florida, Gainesville, FL

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94 An internet-based voucher program for smoking abstinence I.M. Glenn, S.E. Meredith and J. Dallery, University of Florida, Gainesville, FL 95 Dose-dependent effects of transdermal nicotine on working-memory in abstinent smokers B. Kleykamp, M.D. Blank, J.M. Jennings, M.F. Weaver and T. Eissenberg, Virginia Commonwealth University, Richmond, VA and Wake Forest University, Winston-Salem, NC 96 Newer smokeless tobacco products compared to medicinal nicotine: Health and behavioral consequences M.I. Mendoza-Baumgart and D.K. Hatsukami, University of Minnesota, Minneapolis, MN

EPIDEMIOLOGY 97 Age differentials in the impacts of reduced heroin supply: Effects of a “heroin shortage” in NSW, Australia L.J. Degenhardt, C. Day, E. Conroy, S. Gilmour and W. Hall, University of New South Wales, Sydney, Australia 98 dependence in Iran: A continuing habit with intriguing nature and course A. Mokri, H. Taherinakhost, M.C. Chawarski and R.S. Schottenfeld, Iranian National Center for Addiction Studies, Tehran, Iran and Yale University School of Medicine, New Haven, CT 99 Illegal drug use in Peru: Recent epidemiological estimates M. Piazza, F. Salazar, G.F. Alvarado, R. Durand, A. Lescano, D. Blichtein and E. Nunez, Universidad Peruana Cayetano Heredia, Lima, Peru and DEVIDA and Cooperacion Tecnica Belga, Lima, Peru 100 Characteristics of poisoning fatalities in Massachusetts, 1990-2001 J.D. Wines, Jr. and H. Hackman, McLean Hospital/Harvard Medical School, Belmont, and Massachusetts Department of Public Health, Boston, MA 101 Mortality in a cohort of opiate users at the Vienna Addiction Clinic S. Bauer, R. Loipl, D. Gruber, R. Jagsch, D. Risser and G. Fischer, Medical University of Vienna, Vienna, Austria 102 Opportunistic infections among persons with HIV, substance abuse, and serious mental illness: A Medicaid cohort study M.B. Blank, D.S. Metzger, A.B. Rothbard and W.S. Thompson, University of Pennsylvania, Philadelphia, PA and Center for Disease Control and Prevention, Atlanta, GA 103 Substance use in the morbidly obese: Do addictive processes overlap? D.L. Haller, M.C. Acosta and M.E. Olbrisch, St. Luke’s-Roosevelt Hospital Center and Columbia University, New York, NY and Virigina Commonwealth University Medical Center, Richmond, VA 104 Overweight, drug involvement, and other psychosocial problems among graduating seniors from a historically Black college F.A. Wagner, S.M. Gross, P.A. Clubb and D.C. Browne, Morgan State University, Baltimore, MD 105 Potential impact of social roles on transitions in drug use among urban African American adults H.S. Reisinger, K.D. Dowling, M.E. Ensminger and H.D. Chilcoat, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 106 Childhood trauma among drug-involved, street-based sex workers in Miami J.C. Weaver, C.E. Spadola and H.L. Surratt, University of Delaware, Coral Gables, FL 106.5 106.5

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107 Drug-involved sex workers formerly placed in foster care C.E. Spadola, J.C. Weaver and J.A. Inciardi, University of Delaware, Coral Gables, FL 108 Exposure to traumatic events in offspring of drug-dependent fathers A.E. Duncan J.F. Scherrer, J.D. Grant and K.K. Bucholz, Washington University School of Medicine, Saint Louis University School of Public Health, and Veterans Administration Medical Center, St. Louis, MO OPIOID PHARMACOTHERAPY 109 Interim methadone maintenance: 10 month follow-up R.P. Schwartz, D.A. Highfield, R.J. Battjes, J.M. Callaman, K.E. O’Grady, C. Butler, C. Rouse, J.V. Brady and J.H. Jaffe, Friends Research Institute, University of Maryland, College Park, and University of Maryland School of Medicine, Baltimore, MD 110 Interim methadone maintenance: Successes versus failures D.A. Highfield, R.P. Schwartz, J.H. Jaffe, J.M. Callaman, K. O’Grady, R. Battjes, C. Butler, C. Rouse and J.V. Brady, Friends Research Institute, and University of Maryland School of Medicine, Baltimore, MD 111 Incorporating family and friends to build support networks among patients on methadone K.B. Stoller, M.S. Kidorf, V.L. King, K. Neufeld, J. Peirce and R.K. Brooner, Johns Hopkins University School of Medicine, Baltimore, MD 112 Comparing adaptive “stepped care” methadone treatment approaches with standard methadone treatment with and without voucher-based monetary incentives R.K. Brooner, M.S. Kidorf, V.L. King, K.B. Stoller, K.J. Neufeld and J. Peirce, Johns Hopkins University School of Medicine, Baltimore, MD 113 Optimal dosing strategies in opioid maintenance J.G. Grabowski, F.G. Moeller, A. Dougherty, A. Stotts, A. Garcia, K. McQueen, H.M. Rhoades, G. Ingersoll, I. Daher, R.A. Meisch and J.M. Schmitz, University of Texas Health Science Center-Houston, Baylor College of Medicine, Houston, and University of Texas Medical Branch-Galveston, Galveston, TX 114 Clinically insignificant changes in QT intervals in methadone maintenance treatment patients E. Peles, G. Bodner, M.J. Kreek and M. Adelson, Tel Aviv Medical Center, Israel and The Rockefeller University, New York, NY 115 Abstinence achievement during opioid agonist maintenance treatment: When to shift gears? R.S. Schottenfeld, M.C. Chawarski and D. Fiellin, Yale University School of Medicine, and The APT Foundation, New Haven, CT 116 Natural history of slow taper attempts from methadone maintenance treatment D.A. Calsyn, J.A. Malcy and A.J. Saxon, VA Puget Sound HCS, University of Washington School of Medicine, Seattle, WA and VA Medical Center, Martinsburg, WV 117 Comparison of /quinidine with supportive pharmacological treatment for heroin withdrawal symptoms E. Akerele, H. Kleber, A. Bisaga and M. Chicurel, Columbia University/New York State Psychiatric Institute, New York, NY 118 Heroin-dependent individuals discount heroin at very short delays, more so during imagined than satiation M.K. Greenwald and L.A. Haunert, Wayne State University, Detroit, MI 119 Antinociceptive effects of in methadone-maintained patients J.L. Hay, J.M. White, A.A. Somogyi and F. Bochner, University of Adelaide, Australia

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120 Perceptions of treatment needs and experiences of individuals with co-occurring opioid analgesic dependence and chronic pain: A qualitative study J.S. Potter, I.B. Janis and R.D. Weiss, McLean Hospital/Harvard Medical School, Belmont, MA 121 Patterns of analgesic use in chronic pain patients treated with AVINZA: A modified-release morphine formulation E.H. Adams, Y. Ace-Wagoner, B. Mangefrida, M. Duerden and M. Witt, Harris Interactive, Princeton, NJ and Rehabilitation Associates of Indiana, Indianapolis, MN OPIOIDS: PSYCHOSOCIAL TREATMENT 122 Relationship between impulsivity and route of administration in opiate-dependent adult outpatients at intake and during treatment K.M. Gatchalian, R. Yi, A.R. Buchhalter and W.K. Bickel, University of Arkansas for Medical Sciences, Little Rock, AR and Pinney Associates, Bethesda, MD 123 Case management improves entry into drug treatment among injection drug users referred from a needle exchange program S.A. Strathdee, E.P. Ricketts, S. Huettner, L. Cornelius, D. Bishai, J.R. Havens, P. Beilenson, C. Rapp, J.J. Lloyd and C.A. Latkin, University of California, San Diego, CA, Johns Hopkins University, University of Maryland, Baltimore, MD, University of Kentucky, Lexington, KY and University of Kansas, Kansas City, KS 124 Comparing psychiatric and substance-use problems in untreated opioid-dependent syringe exchange participants to methadone treatment seekers P. Carroll, E. Disney, J. Peirce, V. King, M. Kidorf and R. Brooner, Johns Hopkins University, Baltimore, MD 125 Opening doors to treatment: A voucher-enhanced motivational intervention for syringe exchange participants E.R. Disney, M. Kidorf, K. Kindbom, J. Blucher, L. Williams, J. Depo, C. Sawyer and R.K. Brooner, Johns Hopkins University School of Medicine, Baltimore, MD 126 Predictors of therapeutic response to contingent fee rebates during outpatient treatment of opioid dependence J.B. Kamien, L. Amass, T.S. Samiy, A.J. Cohen and C. Reiber, Friends Research Institute, Inc., Los Angeles, and Aegis Medical Systems, Agoura Hills, CA 127 Behavioral economic analysis of naturalistic heroin demand J. Roddy and M.K. Greenwald, Wayne State University, Detroit, MI 128 The iterated prisoner’s dilemma game and delay discounting in opiate users R. Yi, A.R. Buchhalter, K.M. Gatchalian and W.K. Bickel, University of Arkansas for Medical Sciences, Little Rock, AR and Pinney Associates, Bethesda, MD 129 Impact of reinforcement-based therapy on HIV high-risk behavior in heroin abusers J.A. Hanner, H.E. Jones, C. Wong, M. Tuten and M.L. Stitzer, Johns Hopkins Hospital and Bayview Medical Center, Baltimore, MD POLYDRUG ABUSE/DRUG INTERACTIONS 130 Thinking outside the box: A case of apparatus bias resolution for place conditioning P.G. Roma and A.L. Riley, American University, Washington, DC 131 Comparison of the discriminative stimulus and reinforcing effects of heroin-benzodiazepine combinations in rhesus monkeys S.C. Licata, D.M. Platt and J.K. Rowlett, Harvard Medical School, New England Regional Primate Research Center, Southborough, MA

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132 Repeated choice and memory-task performance predicts drug use in non-clinic subjects G.M. Heyman and B.J. Dunn, McLean Hospital/Harvard Medical School, Belmont, MA 133 Effects of acute propranolol administration on risk-taking behavior in substance abusers in a laboratory setting O.V. Tcheremissine, S.D. Lane, D.R. Cherek, L.M. Lieving and S.O. Nouvion, University of Texas Houston Health Science Center, Houston, TX 134 Differences in impulsivity and risk-taking propensity between primary users of crack/cocaine and primary users of heroin in a residential substance-use program M.A. Bornovalova, S.B. Daughters, A. Delany-Brumsey, B.A. Kohrt and C.W. Lejuez, University of Maryland, College Park, MD 135 Analysis of gambling-task performance of substance abusers and controls R.N. Ehrman, M.R. MacDougall, C. Lejuez, K. Marquez, J.G. Hakun, and A.R. Childress, University of Pennsylvania School of Medicine, VA Medical Center, Philadelphia, PA and University of Maryland, College Park, MD 136 Professional demeanor of chronically unemployed cocaine-dependent methadone patients in a therapeutic workplace C.M. Carpenedo, M. Needham, T.W. Knealing, K.B. Kolodner, C.J. Wong and K. Silverman, Johns Hopkins University School of Medicine, Baltimore, MD 137 Measuring employment: Implications for drug abuse research J.M. Webster, M. Staton Tindall, J.L. Duvall, M. Schumacher, T.F. Garrity and C.G. Leukefeld, University of Kentucky, Lexington, KY 138 Antecedent factors related to injection drug use K.F. Corsi, N. Asdigian and R.E. Booth, University of Colorado Health Sciences Center, Denver, CO 139 The association between heroin use and anxiety sensitivity among inner-city individuals in residential drug-use treatment A.M. Paulson, S.B. Daughters, M.A. Bornovalova, K. Belendiuk and C.W. Lejuez, University of Maryland, College Park, MD 140 Modulating the effects of primary drugs of use: A qualitative study of polydrug use histories among recently initiated injection drug users in San Juan, Puerto Rico A. Finlinson, H.M. Colon, R.R. Robles and M. Soto, Universidad Central del Caribe, Bayamon, PR 141 Women in long-term relationships with drug-using men: The experiences of Indo-Trinidadian women M. Mahadeo, Medical and Health Research Association of New York, Inc., Columbia University, New York, NY and Caribbean Health Research Council, St. Augustine, Trinidad and Tobago 142 A phase 1 clinical safety study of the 3-way drug interactions between disulfiram, cocaine, and alcohol in cocaine-dependent research volunteers C.L. Wallace, T.F. Newton, A. Elkashef, R. Kahn, J. Mojsiak, R. de la Garza, N. Chang and J.D. Roache, University of Texas Health Science Center, San Antonio, TX, University of California, Los Angeles, CA and NIDA, Bethesda, MD 143 The physiological and subjective effects of racemic methadone and its individual enantiomers: A double-blind, placebo-controlled study in healthy volunteers M. Nguyen, A.L. Farquharson, O.V. Lopatko, A.A. Somogyi and J.M. White, University of Adelaide, Adelaide, Australia

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144 The effect of oral naltrexone on the opioid-agonist properties of : A pilot study R.F. Kaiko, R.D. Colucci, C.D. Breder, J. Stewart, and C. Wright, Purdue Pharma, L.P., Stamford, CT, and MDS Harris Clinical Research, Belfast, Northern Ireland 145 Pharmacodynamic interactions between diazepam with methadone, and diazepam with buprenorphine in opioid-dependent individuals N. Lintzeris, T. Mitchell, A. Bond, L. Nestor and J. Strang, Maudsley Hospital, London, England 146 The effect of cocaine use on treatment outcomes for heroin dependence: Twelve-month results from the Australian Treatment Outcome Study A.B. Williamson, S. Darke, J. Ross and M. Teesson, University of New South Wales, Kensington, Australia 147 Methamphetamine abuse during treatment for heroin dependence in Malaysia M. Mazlan, M.C. Chawarski and R.S. Schottenfeld, Substance Abuse Center, Muar, Malaysia and Yale University School of Medicine, New Haven, CT 148 The subjective effects of intravenous methamphetamine during treatment with bupropion T. Fong, T.F. Newton, J.D. Roache, A.D. Kalechstein, R. de la Garza, II, C. Wallace, M. Dawes, D. Bloch, T. Holmes, A. Elkashef and N. Chiang, University of California, Los Angeles, CA, University of Texas, San Antonio, TX, NIDA, Bethesda, MD and Stanford University, Palo Alto, CA 149 Aripiprazole attenuates the discriminative-stimulus effects of d-amphetamine C.R. Rush, J.A. Lile, W.W. Stoops, A.R. Vansickel, P.E.A. Glaser and L.R. Hays, University of Kentucky College of Medicine, Lexington, KY 150 Frequency of marijuana use predicts retention and treatment outcome in office-based buprenorphine treatment for opioid dependence B.A. Moore, R.S. Schottenfeld and D.A. Fiellin, Yale University School of Medicine, New Haven, CT 151 Energy drinks affect subjective effects of alcoholic intoxication in volunteers S.E. Ferreira, M.T. Mello and M.L.O. Souza-Formigoni, Federal University of Sao Paulo, San Paulo, Brazil 152 Differential DAT occupancy of methylphenidate hydrochloride (CONCERTA®) and immediate- release (Ritalin®) compared in subjects with substance abuse D.F. Wong, W. Ye, M. Thomas, J.R. Brasic, A. Nandi, M. Alexander, M. Maris, J. Hilton, P. Ciccone, C. Hooper-Wood and D. Jasinski, Johns Hopkins University, Baltimore, MD and McNeil Consumer and Specialty Pharmaceuticals, Fort Washington, PA Symposium XV Scotland 9:30 - 11:30 AM ADVANCING TREATMENT FOR MARIJUANA DEPENDENCE: PHARMACOLOGICAL AND BEHAVIORAL TREATMENT DEVELOPMENT

Chairs: Alan J. Budney and Margaret Haney 9:30 Novel medication development for cannabis dependence targeting brain reward circuitry Alan I. Green, Dartmouth Medical School, Lebanon, NH 9:55 Laboratory models of marijuana dependence: Effect of potential treatment medications Margaret Haney, College of Physicians and Surgeons of Columbia University, New York, NY

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10:20 Marijuana dependence treatment for adults, PRN Robert S. Stephens, Virginia Tech, Blacksburg, VA 10:45 Novel behavioral treatments for adolescent marijuana abusers and their parents Alan J. Budney, University of Vermont, Burlington, VT 11:10 Discussant Frank Vocci, National Institute of Drug Abuse, National Institutes of Health, Bethesda, MD

Oral Communications XX Crown Hall 9:30 - 11:30 AM CHEMISTRY: FUN WITH BONDS AND CHAINS

Chairs: Matthew D. Metcalf and Mark P. Wentland 9:30 Refinement of the delta opioid antagonist conformationally sampled pharmacophore using 5’-halogen-substituted analogs of naltrindole M.D. Metcalf, D. Bernard, X. Yang, J.B. Wang, A.D. MacKerell Jr. and A. Coop, University of Maryland School of Pharmacy, Baltimore, MD 9:45 Kappa opioid receptor antagonists in the 2-amino-1,1-dimethyl-7-hydroxytetralin series I.A. Williams, J.W. Lewis, J.R. Traynor and S.M. Husbands, University of Bath, Bath, UK and University of Michigan, Ann Arbor, MI 10:00 A novel 4-hydroxy analogue of naltrexone with exceptional affinity for the mu receptor M.P. Wentland, Q. Lu, B.I. Knapp and J.M. Bidlack, Rensselaer Polytechnic Institute, Troy, and University of Rochester, Rochester, NY 10:15 Pharmacological evaluation of novel N-8-substituted-benztropanamine analogs P. Grundt, T. Kopajtic, J.L. Katz and A.H. Newman, NIH/NIDA Intramural Research Program, Baltimore, MD 10:30 The search for cocaine pharmacotherapies continues: Analogs of pyrrolidinyltolyl pentanone () are potent inhibitors of monoamine transport P.C. Meltzer, B.K. Madras and D. Butler, Organix Inc. Woburn, MA and Harvard Medical School and New England Regional Primate Research Center, Southborough, MA 10:45 Asymmetric synthesis and opioid-binding affinity of chiral N-substituted octahydro-1H- benzofuro[3,2-e]isoquinolines, the ACNO partial structure derivatives of morphine L.W. Hsin, L.T. Chang, C.M. Dersch and R.B. Rothman, National Taiwan University, Taipei, Taiwan and NIH/NIDA Intramural Research Program, Baltimore, MD 11:00 Long chain N-n-alkylnicotinium analogs inhibit nicotinic receptors probed by [3H]nicotine binding, but not [3H] binding to rat brain membranes P.A. Crooks, G. Zheng, A.G. Deaciuc, F. Zheng and L.P. Dwoskin, University of Kentucky, Lexington, KY 11:15 Design, synthesis and evaluation of non-peptide corticotropin-releasing hormone receptor type 1 antagonists for imaging studies B.M. Kim, C. Yeom, D. Lee, I. Kim, E. Greiner, E. Jagoda, C. Contoreggi, S. Listwak, P. Gold, G. Chrousos, W. Eckelman and K. Rice, Seoul National University, Seoul, Korea, NICHHD, NIDA/NIH, Bethesda, MD

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Oral Communications XXI England 9:30 - 11:30 AM GROWING PAINS: DRUGS IN ADOLESCENTS

Chairs: Jody L. Kamon and Stephen Magura 9:30 Drug-dealing and recent-onset cannabis users in the U.S, 2003: A re-approach based on a nationally representative sample of 1,244 youths C.P. Obando, C.F. Ríos-Bedoya and J.C. Anthony, Michigan State University, East Lansing, MI 9:45 Using the Balloon Analogue Risk Task to identify substance-use, risky sexual behavior, and delinquency within a sample of inner-city adolescents W.M. Aklin, C.W. Lejuez, A. Lazerow, F. Tyler, M.J. Zvolensky and C.W. Kahler, University of Maryland, College Park, MD, University of Vermont, Burlington, VT and Brown University, Providence, RI 10:00 Using Latent Transition Analysis to model substance-use onset among adolescents: Examining the Gateway Hypothesis among Puerto Rican youth M.M. Maldonado-Molina, L.M. Collins, R.R. Ramirez, G. Canino and T.A. Ridenour, Penn State University, State College, PA and University of Puerto Rico, San Juan, PR 10:15 Effectiveness of peer-mentoring group activity in HIV-affected youths’ selection of substance- using peers S. Magura, C. Fong, A. Rosenblum, P. Curry, C. Norwood, D. Casella and J. Skinner, National Development and Research Institutes, Inc., New York, and Health People, Inc., Bronx, NY 10:30 Gender, adolescent substance-use disorders, and young-adult personality-disorder outcomes D.L. Thatcher and D.B. Clark, University of Pittsburgh, Pittsburgh, PA 10:45 Adolescents with severe substance-use disorders and ADHD L. Payne, P. Clemmey and M. Fishman, Potomac Healthcare Foundation, Woodbridge, VA, Mountain Manor Treatment Center and Johns Hopkins University, Baltimore, MD 11:00 Prevalence and correlates of withdrawal in adolescents presenting for substance-abuse treatment J.L. Kamon, A.J. Budney, M.L. Dennis and R.R. Funk, University of Vermont, Burlington, VT and Chestnut Health Systems, Bloomberg, IL 11:15 Brief intervention for drug use with homeless adolescents: A preliminary report J.S. Baer, P.L. Peterson, E.A. Wells, S.B. Garrett, D.M. Rhule and S.W. Bowen, University of Washington, Seattle, WA

BADGES MUST BE WORN IN ALL SCIENTIFIC SESSIONS

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Oral Communications XXII Ireland 9:30 - 11:30 AM GENES: IT'S A SMALL WORLD AFTER ALL

Chairs: Joshua M. Gulley and Mary Jeanne Kreek 9:30 Persistent increases in rat hypothalamic neuropeptide gene expression with HPA hyposensitivity to naloxone during withdrawal from chronic escalating-dose cocaine Y. Zhou, J. Huynh, J. Choi, S.D. Schlussman, J. Adomako-Mensah, A. Ho and M.J. Kreek, The Rockefeller University, New York, NY 9:45 Individual differences in psychostimulant-induced behaviors: Dopamine transporters, genetics and conditioning J.M. Gulley, R.M. Allen, C.V. Everett and N.R. Zahniser, University of Illinois, Champaign, IL, University of Colorado, Denver and Aurora, CO 10:00 A gene-gender interaction in basal cortisol levels in normal human volunteers: Role of the A118G SNP of the mu opioid gene (OPRM1) G. Bart, L. Borg, C. Lilly, A. Ho and M.J. Kreek, The Rockefeller University, New York, NY 10:15 Ethnic- and gender-specific association of the nicotinic alpha 4 subunit (CHRNA4) gene with nicotine dependence M.D. Li, J. Beuten, J.Z. Ma, T.J. Payne, X.Y. Lou, K.M. Crews and R.C. Elston, University of Texas Health Science Center at San Antonio, TX, University of Mississippi Medical Center, Jackson, MS and Case Western Reserve University, Cleveland, OH 10:30 Genetic and environmental contributions to amphetamine use in a national twin sample M.T. Lynskey, A.C. Heath, E.C. Nelson, K.K. Bucholz, P.A.F. Madden, W.S. Slutske, D.J. Statham and N.G. Martin, Washington University School of Medicine, and University of Missouri, St. Louis, MO, Queens Institute of Medical Research, Brisbane, Australia 10:45 Genotype and molecular haplotype analyses of serotonin 1B receptor gene by fluorescent PCR: Molecular implications to drug addiction D. Proudnikov, K.S. LaForge, C.J. Lilly, H. Hofflich, D. Gordon, J. Ott and M.J. Kreek, The Rockefeller University, New York, NY 11:00 Gene expression profiling of the human amygdala in cocaine abuse and excited cocaine delirium D. McCorquodale, Y. Quin, F. Gawdry, J. ffrench-Mullen, J. Pablo and D.C. Mash, University of Miami School of Medicine, Miami, FL, Strand Genomics, Inc., Karnataka, India and Genelogic, Inc., Gaithersburg, MD 11:15 Dopamine D2 receptor TaqI A polymorphism and smoking cessation I. Berlin, L.S. Covey, H. Jiang and D. Hamer, Groupe Hospitalier Universitaire Pitié- Salpêtrière, Paris, France, New York State Psychiatric Institute-Columbia University, New York, NY and National Cancer Institute, NIH, Bethesda, MD

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Oral Communications XXIII Scotland 12:00 - 1:00 PM OPIOID MECHANISMS OF ACTION

Chairs: Laura M. Bohn and Shane A. Perrine 12:00 Morphine-induced side-effects in mice lacking beta-arrestin2 L.M. Bohn and K.M. Raehal, The Ohio State University College of Medicine and Public Health, Columbus, OH 12:15 The effects of cholinergic agonists on mu opioid binding to mouse brain homogenates K.L. Scoggins, M. Hoot, F.L. Smith and W.L. Dewey, Virginia Commonwealth University, Richmond, VA 12:30 Morphine modulates JAM-2 expression in brain microvascular endothelial cells S.D. Mahajan, S.A. Schwartz, R. Chawda, N. McCulloch and M.P.N. Nair, State University of New York at Buffalo, and Buffalo General Hospital, Buffalo, NY 12:45 Delta opioid receptors influence basal anxiety and cocaine withdrawal-induced anxiety in the rat S.A. Perrine and E.M. Unterwald, Temple University School of Medicine, Philadelphia, PA

Oral Communications XXIV Ireland 12:00 - 1:00 PM COMORBIDITY: DOUBLE TROUBLE

Chairs: Susan C. Sonne and Jennifer W. Tidey 12:00 Symptom improvement in co-occurring PTSD and alcohol dependence S.C. Sonne, S.E. Back, K.T. Brady and M.L. Verduin, Medical University of South Carolina, Charleston, SC 12:15 The impact of post traumatic stress disorder on 2-year treatment outcomes for heroin dependence K.L. Mills, University of New South Wales, Sydney, Australia 12:30 Contingency management and bupropion for smoking reductions in outpatients with schizophrenia J. Tidey, D. Rohsenow, G. Kaplan, R. Swift and M. Parikh, Brown University and VA Medical Center, Providence, RI 12:45 Valproate reduces cocaine use in bipolar disorder complicated by alcoholism: Preliminary findings I.M. Salloum, J.R. Cornelius, A. Douaihy, D.C. Daley, L. Kirisci, T.M. Kelly and M.E. Thase, University of Pittsburgh, Pittsburgh, PA

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Oral Communications XXV Crown Hall 12:00 - 1:00 PM DRUG-IMMUNE INTERACTIONS

Chairs: Sulie Chang and Wenzhe Ho 12:00 Alcohol inhibits production of beta-chemokines by natural killer cells T. Zhang, C.J. Guo, S.D. Douglas, D.S. Metzger, Y. Li, Y.J. Wang, X. Wang, C.P. O’Brien and W.Z. Ho, The Children’s Hospital of Philadelphia, and University of Pennsylvania School of Medicine, Philadelphia, PA 12:15 Sigma-1 receptors are involved in the capacity for cocaine to enhance HIV replication and modulate chemokine receptors and cytokine production in the huPBL-SCID mouse G.C. Baldwin, K.M. Whittaker, D.P. Tashkin and M.D. Roth, University of California, Los Angeles, CA 12:30 Morphine’s biphasic effects on the inflammatory response in the brain of rats during endotoxin tolerance H. Zhou and S.L. Chang, Seton Hall University, South Orange, NJ 12:45 Combined immunomodulating activities of MDMA and cannabis in humans: A one-year follow- up controlled study R. de la Torre, S. Abanades, R. Pacifici, S. Pichini, S. Poudevida, E. Menoyo, P.G. Zuccaro, J. Segura and M. Farre, Institut Municipal d’Investigacio Medica, Universitat Pompeu Fabra, Universitat Autónoma de Barcelona, Barcelona, Spain, and Istituto Superiore Sanità, Rome, Italy Symposium XVI England 12:00 - 1:00 PM ETHNIC AND RACIAL DRUG-RELATED HEALTH DISPARITIES

Chairs: Fernando A. Wagner and Howard D. Chilcoat 12:00 Age, period and cohort effects to understand health disparities in drug-use outcomes Howard D. Chilcoat, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 12:20 Substance use and related health disparities on Asian Americans and Pacific Islanders Rumi K. Price, Washington University School of Medicine, St. Louis, MO 12:40 Criminal justice disparities and impact on health on minority communities Martin Y. Iguchi, RAND, Drug Policy Research Center, Santa Monica, CA

Brunch with Champions Outback Restaurant 1:00 - 2:15 PM

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Symposium XVII Ireland 2:15 - 4:15 PM HCV, INTERFERON RESISTANCE, AND DRUG ADDICTION: TRAVELS FROM THE HUMAN GENOME TO THE CLINIC AND BEYOND

Chairs: Michael G. Katze and Michael Gale 2:15 HCV/HIV co-infection Margaret Shuhart, University of Washington, Seattle, WA 2:40 Substance misuse management and psychiatric aspects of interferon treatment Mark L. Willenbring, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 3:05 Molecular mechanisms of interferon resistance and HCV pathogenesis Michael Gale, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 3:30 Epidemiology of intravenous drug abuse and HCV/HIV co-infection Richard Garfein, National Center for HIV, STD, and TB Prevention, CDC, Atlanta, GA 3:55 Functional genomics and HCV-mediated liver disease Discussant: Michael G. Katze, University of Washington, Seattle, WA Oral Communications XXVI Crown Hall 2:15 - 4:15 PM PAIN AND ANALGESIA

Chairs: Charles D. Cook and Anna Borsodi 2:15 Hexapeptide antagonist ligands for the receptor A. Borsodi, O. Gunduz, F. Sipos, L. Kocsis, A. Magyar, A.Z. Ronai, F. Hudecz and S. Benyhe, Hungarian Academy of Science, Szeged, Hungary, Research Group for Peptide Chemistry, Budapest, and Semmelweis University, Budapest, Hungary 2:30 Nociceptive sensitivity in male and female rats using a model of tonic pain C.D. Cook, Virginia Commonwealth University, Richmond, VA 2:45 Kappa opioid receptor agonists attenuate acute morphine antinociceptive tolerance J.L. Mathews, J.M. Bidlack and J.L. Neumeyer, University of Rochester, Rochester, NY and McLean Hospital/Harvard Medical School, Belmont, MA 3:00 Effects of non-peptidic, peripherally selective kappa-opioid agonists against topical capsaicin- induced allodynia in primates E.R. Butelman and M.J. Kreek, The Rockefeller University, New York, NY 3:15 Potential diminishing role for PKC in the expression of morphine tolerance during prolonged exposure to morphine F.L. Smith, G.W. Dalton, P.A. Smith and W.L. Dewey, Virginia Commonwealth University Medical Center, Richmond, VA 3:30 High-dose morphine plus S(+) ketamine or tramadol elicits antinociception in buprenorphine- maintained patients P. Athanasos, C.S. Smith, W. Ling, F. Bochner, A.A. Somogyi and J.M. White, University of Adelaide, Royal Adelaide Hospital, Australia and University of California, Los Angeles, CA

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3:45 Pain management in buprenorphine patients R. Ali, W. Ling, M. Auriacombe, E. Lavie, J. Duber and M. Fatseas, University of Adelaide, Adelaide, Australia, University of California, Los Angeles, CA, and Universite Victor Segalen Bordeaux, France 4:00 A novel, dual-mechanism analgesic-potentiating agent M. Dukat and S. Young, Virginia Commonwealth University, Richmond, VA

Oral Communications XXVII England 2:15 - 4:15 PM PHARMACOLOGICAL TREATMENTS FOR COCAINE DEPENDENCE

Chairs: Jennifer R. Baker and Mehmet Sofuoglu 2:15 Systemic administration of the L-type calcium-channel antagonist diltiazem attenuates cocaine priming-induced reinstatement S.M. Anderson and R.C. Pierce, Boston University School of Medicine, Boston, MA 2:30 Disulfiram reduces cocaine self-administration and cocaine-induced reinstatement of drug- seeking behavior in rats X.Y. Zhang, C.N. Haile, T.R. Kosten and T.A. Kosten, Yale University School of Medicine, West Haven, CT 2:45 Disulfiram effects on intravenous cocaine administration J.R. Baker, P. Pade, P. Jatlow, S. Lin and E.F. McCance-Katz, Virginia Commonwealth University, Richmond, VA, Yale University, New Haven, CT and University of Utah, Salt Lake City, UT 3:00 The influence of dopamine D2 and D3 receptors in cocaine- and food-maintained responding under a second-order schedule in monkeys R. Claytor, M.A. Nader, and A.H. Newman, Wake Forest University Health Sciences, Winston-Salem, NC and NIH/NIDA Intramural Research Program, Baltimore, MD 3:15 Preclinical assessment of monoamine releasers as treatments for cocaine dependence S.S. Negus, N.K. Mello, B.E. Blough, M.H. Baumann and R.B. Rothman, McLean Hospital, Belmont, MA, Research Triangle Institute, Research Triangle Park, NC and NIH, Intramural Research Program, Baltimore, MD 3:30 A placebo-controlled trial of gabapentin for cocaine dependence E.V. Nunes, A. Bisaga, E. Aharonovich and F. Garawi, Columbia University, New York, NY 3:45 Six-month trial of bupropion with contingency management for cocaine dependence J. Poling, A. Oliveto, K. Gonsai, M. Sofuoglu, G. Gonzalez, B. Martell and T.R. Kosten, Yale University School of Medicine, and VA Connecticut Healthcare System, West Haven, CT 4:00 Tiagabine attenuates the subjective effects of cocaine in humans M. Sofuoglu, E. Mitchell and T.R. Kosten, Yale University School of Medicine, and VA Connecticut Healthcare System, West Haven, CT

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Symposium XVIII Scotland 2:15 - 3:15 PM SMOKING AND WOMEN: THE INFLUENCE OF MENSTRUAL CYCLE

Chair: Sharon Allen 2:15 Relapse to smoking in women: Role of the menstrual cycle Sharon Allen, University of Minnesota Medical School, Minneapolis, MN 2:35 Variations in nicotinic acetylcholine receptor expression across the menstrual cycle: A brain mechanism mediating variations in smoking behavior Julie Staley, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, CT 2:55 Menstrual cycle phase at quit date: Effect on treatment outcome, irrespective of treatment modality Discussant: Teresa R. Franklin, University of Pennsylvania and VA Medical Center, Philadelphia, PA

SWEEPSTAKES DRAWING England 4:30 PM YOU MUST BE SEATED IN ONE OF THE SESSIONS AT 4:15 PM IN ORDER TO HAVE YOUR BADGE COLLECTED

HAVE A SAFE TRIP HOME. SEE YOU IN SCOTTSDALE, ARIZONA, JUNE 17-22, 2006!

84 AUTHOR INDEX

Abanades, S. 17, 81 Amaro, H. 66 Baiget, M. 31 Abood, M.E. 63 Amass, L. 43, 55, 74 Bailey, A. 52 Accornero, V.H. 36, 47 Ambrosio, E. 30 Bailey, U.O. 31, 36 Ace-Wagoner, Y. 74 Amin, M.R. 63 Bajpai, L.K. 13 Aceto, M.D. 53 Amodeo, M.A. 48, 56, 66 Baker, J.R. 22, 54, 83 Acharyya, S. 8 Amodio, K. 6 Balducci, X.L. 18 Achat-Mendes, C. 3 Amrhein, P.C. 33 Baldwin, G.C. 81 Acheson, A. 38 Anderson, C.M. 10 Baldwin, R.M. 9, 21 Acosta, M.C. 72 Anderson, G. 12 Ball, K.T. 3 Adams, E.H. 74 Anderson, K.G. 51 Ball, S.A. 17, 56 Adelson, M. 73 Anderson, K.L. 11 Balster, R.L. 1, 68 Adewale, A.S. 20 Anderson, M.J. 23 Bammer, G. 19 Adler, M.W. 53, 54 Anderson, S.M. 83 Bandstra, E.S. 36 Adomako-Mensah, J. 79 Ang-Lee, K. 46 Bangalore, D. 54 Afful, S.E. 8, 34 Anker, J.J. 29 Banks, M.L. 29 Agius, E. 41 Anselmo, E. 34 Bañuls, E. 31 Agudelo, M. 53 Anthony, J.C. 6, 7, 15, 16, Bar-Hamburger, R. 3, 10, 22, 47 Aguilar, J. 41 31, 34, 36, 42, 47, 48, 49, 78 Barbosa, C. 65 Aharonovich, E. 18, 31, 33, 83 Antonova, T.V. 65 Barcelona Group for Ahluwalia, B. 36 Aoki, T. 12 Addiction Genetics 31 Ahmed, M.S. 4, 36, 37 Apelt, S.M. 54 Bardo, M.T. 12, 46, 52, 53 Ainslie, G. 42 Apparsudaram, S. 24 Barkai, U. 43 Akerele, E. 73 Arasteh, K. 21 Barksdale, W. 40, 57 Akhavan, A. 29 Arfken, C.L. 4, 7, 41, 56, Barrett, A.C. 12, 50 Akinshola, B.E. 53 68 Barros, T.L. 10 Aklin, W.M. 48, 71, 78 Ariely, D. 9 Barry, D.T. 55, 56 al'Absi, M. 23 Arnold-Reed, D. 55 Bart, G. 23, 31, 79 Alapont, L. 40 Aron, A. 45 Basak, A.K. 63 Albeck, H. 17 Asato, M. 12 Bastos, F.I. 19, 65 Albers, E.C. 66 Asdigian, N.L. 54, 75 Batis, J.C. 38 Aleixandre, R. 4, 40 Ashba, J. 56 Batki, S.L. 6 Alexander, M. 76 Asnicar, M.A. 5 Battistich, V. 48 Alexander, R. 43 Astone-Twerell, J.M. 64 Battjes, R.J. 73 Alford, A. 24 Athanasos, P. 82 Bauer, S. 72 Alford, D.P. 56 Atkins, A.L. 11 Baumann, M.H. 3, 29, 83 Alhamrawy, I.A. 11 Aubie, C. 59 Bauzo, R.M. 5 Ali, R. 70, 83 Audus, K. 36 Beardsley, P.M. 26, 50 Ali, S.F. 3, 11 Auriacombe, M. 21, 83 Beatrice, S. 21 Alibhai, I.N. 11 Avalos, L. 36 Beatty, J.R. 19, 36 Allagille, D. 21 Averill, P. 34 Bechara, A. 32 Allen, A.M. 71 Azevedo, W.B. 65 Becker, K.G. 31 Allen, R.M. 41, 79 Bedoya, L. 66 Allen, S.S. 71, 84 Babayev, H.B. 71 Beilenson, P. 74 Allen, T. 66 Back, S.E. 8, 12, 35, 66, Belendiuk, K. 75 Allen, T.M. 24 80 Belenko, S. 66 Allen-Ferdinand, K. 17 Badger, G.J. 37, 43 Belin, T. 19 Allsop, S. 70 Bae, S.C. 9, 10, 11 Belknap, J.K. 11 Alvanzo, A.H. 37 Bae, S.J. 9, 11, 45 Bellack, A.S. 17 Alvarado, G.F. 42, 72 Baer, J.S. 78 Belyaeva, T.V. 65 Alvarez, E. 31 Baewert, A. 6 Ben Abdallah, A. 16, 34, 40 Alvarez-Gonzalez, C. 14 Bagot, K.S. 70 Benamar, K. 53

85 AUTHOR INDEX

Bence, L.E. 13, 52 Boja, E.S. 13 Bucardo, J. 66 Bender, R.E. 18 Bolla, K. 9, 59 Buchhalter, A.R. 74 Benford, J. 67 Bond, A. 76 Bucholz, K.K. 31, 32, 43, 73, Benitez, J. 15, 67 Bondora, A. 22 79 Benlhabib, H. 24 Booth, R.E. 54, 75 Budney, A.J. 69, 77, 78 Bennett, M.E. 17 Booze, R.M. 30 Budreau, D. 3 Benyhe, S. 82 Bopp, G. 42 Bueno, O.F. 21 Berardi, K. 59 Borg, L. 79 Burdash, N. 53 Berenson, A.B. 16 Bornovalova, M.A. 48, 75 Burdon, W.M. 68, 69 Berger, S.P. 33 Borsodi, A. 82 Burke, C. 42 Bergman, J. 9, 11, 50, 53 Bounds, M. 10 Burke, K.A. 51 Berko, J.R. 70 Bowden, C. 18 Burleson, J.A. 47, 48 Berlin, I. 79 Bowen, S.E. 38 Burmeister, J.J. 50 Bernard, D. 77 Bowen, S.W. 78 Burns , L. 62 Berns, S.B. 56 Bowman, E.R. 53 Burroughs, D. 53 Bernstein, I.M. 37 Boyd, C.J. 39 Burrows, A.M. 14 Berrettini, W.H . 61 Boyd, S.J. 11, 23, 59 Burstein, M. 8 Berry, T.R. 39 Bradford, S. 34 Busch, S. 42 Better, W. 9, 10, 32, 41, Brady, J.V. 73 Busse, G.D. 14 54, 59 Brady, K.T. 12, 19, 33, 35, Bustamante, I. 47 Betzler, T. 67 59, 80 Busto, U.E. 18, 42, 59 Beuten , J. 79 Brands, B. 4, 18 Butelman, E.R. 82 Beveridge, T.J.R. 51 Brasic, J.R. 76 Butler, C. 73 Bickel, W.K. 1, 21, 26, 74 Brazhenko, N.A. 65 Butler, D. 77 Bidlack, J.M. 77, 82 Brecht, M. 46 Bux, Jr., D.A. 57 Bierut, L.J. 8, 34 Breder, C.D. 76 Bigelow, G.E. 33, 49, 56 Brethen, P. 47 Cadet, J.L. 9, 10, 32, 41, Bilangi, R. 17 Brickner, O. 10 54, 59 Bilsky, E.J. 13 Brimson, M. 9 Cage, B. 15 Bindukumar, B. 54 Brisgone, R.E. 8 Cain, M.E. 12, 52 Bisaga, A. 18, 22, 24, 33, Britt, G.C. 37 Caine, S.B. 21, 50 73, 83 Britton, A.F. 24 Calabrese, J.R. 18 Biscaia, M. 30 Brooks, A.C. 18, 33 Callahan Meeks, C. 34 Bishai, D. 18, 74 Brooks, D.J. 35 Callaman, J.M. 68, 73 Blair, M. 66 Brooks, M.P. 23 Calsyn, D.A. 56, 73 Blakesley-Ball, R. 24 Brooner, R.K. 17, 34, 36, 73, Camal, N.A. 16 Blanchard, K. 57 74 Camilleri, A. 39 Blank, M.B. 72 Brower, K. 57 Campbell, J.V. 6, 65 Blank, M.D. 72 Brower, V. 43 Campbell, K. 57 Blichtein, D. 72 Brown, A. 8 Campollo, O. 14, 36, 48 Bloch, D. 76 Brown, B.S. 40, 57, 68 Canfield, K. 6 Bloch, M. 10 Brown, H. 69 Canino, G. 78 Block, W. 42 Brown, L.S. 66, 67 Cannistraci, C. 9 Blough, B.E. 83 Brown, R.W. 12, 30 Cardenas, L. 42 Blucher, J. 74 Brown, S. 16 Cardus, M. 31 Bobrik, A. 65 Browne, D.C. 42, 72 Carelli, R.M. 51 Bochner, F. 73, 82 Browning, C.E. 30 Carey, M.P. 66 Bodner, G. 73 Brownstein, J. 38 Caris, L.H. 34 Boehm, G.W. 60 Bruijnzeel, A.W. 13 Carise, D. 39 Bohn, L.M. 13, 80 Bruntz, R.C. 24 Carlson, K.A. 30 Bohnert, K.M. 31, 34 Brusco, A. 53 Carmody, T. 46

86 AUTHOR INDEX

Carolan, S. 66 Chen, X. 54 Conklin, C.A. 71 Caron, M. 25 Cheng, D.M. 56 Conroy, E. 72 Carpenedo, C.M. 75 Cheng, W.J.Y. 71 Constable, R.T . 41 Carpenter, K. 55 Cherek, D.R. 32, 38, 75 Contoreggi, C. 53, 77 Carpenter, M.J. 59 Cherrier, M. 46 Convey, L.S. 2 Carr, S.M. 68 Chiang, N. 76 Cook, C.D. 82 Carrigan, K.A. 14, 20 Chicurel, M. 73 Cook, J.M. 22 Carrión, I. 67 Chilcoat, H.D. 6, 7, 15, 38, Coop, A. 14, 28, 77 Carroll, F.I. 14, 49, 62 39, 40, 42, 43, 47, 58, 59, 72, 81 Copeland, J. 16, 48, 70 Carroll, K.M. 17 Childress, A.R. 10, 18, 42, 47, Copenhaver, M.M. 21, 64 66 Carroll, M.E. 29 75 Copersino, M.L. 11, 33, 41 Carroll, P. 74 Childs, E.C. 12 Corbin, R.A. 67 Cartajena, F. 34 Childs, E.L. 20, 31 Cordova, X. 42, 45 Carter, L.P. 28, 63 Chivers, L.L. 71 Corley, R.P. 31 Carway, J. 44, 57 Choder, S. 35 Cornelius, J.R. 15, 31, 35, 80 Casadonte, P. 55 Choi, J.C. 23, 79 Cornelius, L.J. 18, 74 Casella, D. 78 Chrousos, G. 77 Corsi, K.F. 54, 75 Cassidy, M.P. 63 Chu, A.Y. 18 Cortes, M. 34 Cassuto, Y. 22 Chu, M. 40, 57, 66 Cosgrove, K.P. 9 Castellano, M. 4, 40, 41 Chung, A. 9, 10, 11, 45 Cote, M. 35 Caster, J.M. 23, 30 Ciccone, P. 76 Cottler, L.B. 8, 14, 16, 34, Catz-Biro, L. 4 Clark, D.B. 15, 31, 78 37, 40 Caughie, J.M. 43 Clark, R.D. 3 Cottler, L.C. 16 Cederlind, T.M. 46 Claus, R. 57 Courty, P. 32 Ceperich, S.D. 48, 54 Clay, C. 48 Covey, L.S. 79 Cerny, A. 42 Claytor, R. 83 Cowan, R.L. 9 Chabac, S. 49 Clemmey, P. 16, 47, 78 Cox, J.C. 70 Chait, B.T. 14 Clifford, A. 21 Cox, R. 36 Chakravorty, S. 17 Clodfelter, T. 57 Craft, R.M. 12, 41 Chan, C.A. 39, 64 Clubb, P.A. 72 Cramer, J.A. 17 Chan, Y.F. 47 Coady, M. 65 Cravioto, P. 34 Chandler-Ezell, K. 37 Coan, S. 56 Crawford, C.A. 12 Chang, L.T. 77 Cochran, K.R. 19 Crean, R.D. 3 Chang, N. 75 Coffey, S.F. 35 Crespo, J.A. 13 Chang, S.L. 81 Cohan, J. 9 Crews, K.M. 79 Chapman, M. 16 Cohen, J. 22, 54, 65 Crockett, J. 34 Chapman, S.B. 70 Cohen, J.B. 64 Croft, J.R. 41 Chausmer, A.L. 10 Colangelo, C.M. 20 Cronin, H. 56 Chavez Lopez, R. 48 Cole, M. 49 Crooks, P.A. 53, 77 Chawarski, M.C. 22, 56, 65, 72, Collie, C.E. 70 Cropsey, K.L. 68, 71 73, 76 Collins, J. 55 Crosby, S. 62 Chawda, R. 54, 80 Collins, L.M. 6, 78 Crowell, B. 46 Chawdhary, A. 34 Collins, S.L. 35 Crowley, T.J. 16, 31 Cheatwood, L.J. 50 Colon, H.M. 75 Cruz, S.L. 38 Chellis, A. 57 Colub, E.T. 6 Cunha, P.J. 59 Chen, C.Y. 70 Colucci, R.D. 27, 76 Cunningham, C.W. 14 Chen, D.R. 70 Colvis, C. 20 Cunningham, K.A. 49, 50, 51 Chen, J. 31 Comer, S.D. 9, 41, 45, 55 Curry, D. 25 Chen, Q. 11 Comerford, M. 55 Curry, P. 78 Chen, W. 28 Compton, W.M. 44 Curtiss, L.M. 55 Chen, W.J. 70 Condon, T.P. 44 Cutting, D.J. 33

87 AUTHOR INDEX

Cyr, M.C. 12 Dennis, M.L. 28, 44, 57, 69, Durand, R. 72 Czoty, P.W. 10, 29 78 Durell, T.M. 52 Depo, J. 74 Duvall, J.L. 44, 68, 75 D'Amico, E. 15 Dersch, C.M. 13, 77 Dwoskin, L.P. 24, 52, 53, 77 Dacey, J. 59 Des Jarlais, D.C. 21, 64 Dykstra, L.A. 1, 14, 20, 63 Dacon, A. 10 Deshmukh, S.V. 36 Dafny, N. 52 Desrosiers, A. 21 Easton, C.J. 48 Daher, I. 73 Detre, J. 18 Ebener, P. 57 Dahl, J. 57 Deutch, A. 20 Ebner, N. 6 Daley, D.C. 35, 80 Dewey, W.L. 63, 80, 82 Eckelman, W. 77 Dallery, J. 71, 72 Dhopesh, V. 38 Eckler, J.R. 29 Dalton, G.D. 63 Di Pietro, N.C. 51 Edlin, B.R. 6 Dalton, G.W. 82 Diamond, D.L. 20 Edmundson, E. 56 Damesek, L. 57 Diaz, I. 65 Edwards, E. 37 Dankert, N.M. 13, 14 Dickson, M.W. 41 Egorova, V.Y. 65 Dannals, R.F. 11 Diebold, M.D. 10 Ehrman, R.N. 10, 47, 75 Darke, S. 18, 76 Dietze, P. 19 Eichler, O. 42 Dart, R.C. 38, 39 Dillon, F.R. 15 Eid, N.C. 23, 59 Dasgupta, N. 38 Dillon, P. 48 Eiden, R. 37 Daughters, S.B. 75 Disney, E.R. 34, 74 Eisenberg, M.S. 65 Daulouède, J. 21 Divin, M.F. 5 Eisenstein, T.K. 54 Daunais, J.B. 10 Domier, C.P. 8, 42 Eissenberg, T.E. 1, 72 Davidson, C. 11, 50 Donny, E.C. 33 El-Bassel, N. 44 Davies, R. 16 Donohue, L. 6 Elkader, A.K. 18 Davis, C.M. 29 Doshi, D. 40 Elkashef, A. 33, 55, 65, 75, Davis, S.A. 3, 49 Douaihy, A. 80 76 Davis, T.O. 54 Dougherty, A. 73 Ellen, J.M. 70 Dawes, M. 76 Douglas, S.D. 54, 81 Ellinwood, E.H. 11, 50 Day, B.S. 15 Dow-Edwards, D.L. 30, 58 Elliott, B.M. 59 Day, C. 72 Dowdy, E.E. 68 Ellis, M.A. 48 de la Garza, R. 75 Dowling, K.D. 72 Ellison, M. 15 de la Garza, II, R. 33, 45, 59, 76 Dowling, K.M. 43 Elman, I. 9 de la Rosa, M. 15, 19 Draper, J. 37 Elston, R.C. 79 de la Torre, A. 16, 66 Drexler, K.G. 24 Engerman, K. 31 de la Torre, M. 36 Dreyse, J. 34 English, A.L. 36 de la Torre, R. 17, 18, 61, 81 Drobiner, H. 22 Ensminger, M.E. 47, 69, 72 de Vicente, P. 4 Druid, H. 69 Epstein, D.H. 8, 11 de Win, M.M. 58 Duber, J. 83 Ernst, M. 71 de Wit, H. 12, 31, 38 Ducharme, L.J. 39, 56 Eroshina, K. 65 Deaciuc, A.G. 77 Duerden, M. 74 Errico, S. 31 Deckert, J. 31 Dukat, M. 83 Ervin, F.D. 17 Degenhardt, L.J. 72 Duke, A.N. 38 Eschbach, K. 16 Deitz, M.S. 54 Dumchev, K. 22 Escher, T.J. 32 Del Olmo, N. 30 Dumeer, A. 37 Eskesen, J. 10 Del Rio, E. 31 Duncan, A.E. 31,32, 73 Esquivel, D.P. 66 Delany-Brumsey, A. 75 Duncan, E. 24 Evans, E. 40, 49 Delatte, M.S. 9, 53 Dunlap, S. 9 Evans, S.M. 9, 22, 35 DeMatteo, D.S. 4, 69 Dunlop, A. 61 Even-Sapir, E. 3, 10 Dempsey, C.L. 16 Dunn, B.J. 75 Everett, C.V. 79 Denis, C. 21 DuPont, R. 25 Evola, M. 13 Dennis, D.M. 13, 39 Duque, L. 17 Ewing, S.B. 12

88 AUTHOR INDEX

Exhem-Williams, C. 22 Foss, M.A. 69 Garcia, A. 73 Fossey, M. 18 Garcia, M. 8, 12 Fague, M.S. 16 Foster, K.L. 22 García-Lecumberri, C. 30 Fan, J. 40 Fothergill, K.E. 47 Gardner, E. 53 Faranda-Diedrich, T.M. 67 Fox, G. 43, 68 Gardou, C. 32 Farquharson, A.L. 75 Fox, H.C. 12 Garfein, R. 82 Farr, D. 36 Fox, H.S. 49 Garfein, R.S. 6 Farre, M. 17, 18, 81 Fox, M.A. 62 Garner, B.R. 8 Fassler, I. 48 Fox, R.G. 50, 51 Garrett, S.B. 78 Fatséas, M. 21, 83 Fradis, J. 56 Garrity, T.F. 44, 68, 75 Fawkes, T. 66 Fraga, M. 66 Gasior, M. 9, 50 Feltner, D. 38 France, C.P. 28, 38, 63 Gatch, M.B. 14 Feng, P. 54 Frank, E. 35 Gatchalian, K.M. 74 Fernander, A.F . 71 Franken, F.H. 3, 70, 71 Gatenby, J.C. 9 Fernandez, M.A. 9 Franklin, L.M. 23 Gates, P. 48 Fernández, B. 30 Franklin, T.R. 84 Gauchet, A. 10 Fernandez-Ruiz, J. 58 Frantz, K. 30 Gauthereau, M.Y. 38 Ferreira, S.E. 76 Franz, T. 51 Gawdry, F. 79 Ferris, M.J. 30 Frazier, M. 71 Gelacio, S.A. 43 Feske, U. 36 Frederick, B.B. 9 Gelberg, L. 65 Festa, E.D. 30, 52 Freed, W.J. 31 Gelhorn, H.L. 31 Festinger, D.S. 4, 41, 43, 68, Freedman, M.J. 43 Geller, A. 39 69 Freeman, K.B. 51 Geller, E.B. 53, 54 Feussner, G.K. 68 Freese, T. 65 Geng, T. 51 ffrench-Mullen, J. 79 Fried, P. 58 George, T.P. 2, 24 Field, G. 45 Friedman, H. 53 Gerak, L.R. 38 Fields, G. 65 Friedman, S.R. 21 Gerbaud, L. 32 Fiellin, D.A. 22, 54, 55, 56, Friedmann, P. 57 Gershon, P. 22 73, 76 Frohlich, E.B. 9 Gerstein, D. 57 Fife, J.E. 54 Fröhlich, C. 69 Gertner, R. 22 Fileger, M.I. 19 Frost, J.J. 11 Ghandour, L.A. 38, 39 Fingerhood, M. 49 Frost-Pineda, K. 39 Gianani, E.J. 70 Finlinson, A. 75 Fudala, P.J. 53, 55 Gifford, E. 4 Finnegan, L.P. 61 Fuemmeler, B.F. 35 Gilmour, S. 72 Fiore, D. 21, 65 Fulbright, R.K. 41 Gilson, A.M. 19 Fischer, B.D. 14 Fuller, B.E. 56 Ginés, J.M. 18 Fischer, G. 6, 61, 72 Fuller, C.M. 39, 64 Glaser, P.E.A. 46, 52, 76 Fisher, J. 64 Fuller, S. 24 Glenn, I.M. 72 Fishman, M.J. 16, 47, 78 Funk, R.R. 46, 57, 78 Glennon, R.A. 3 Flores, L.E. 66 Furman, M. 34 Godley, M.D. 46 Floyd, L.J. 15, 48, 55, 70 Godley, S.H. 46 Flynn, C.T. 49 Gage, H.D. 10 Goeders, N.E. 14, 30, 50, 51 Flynn, P.M. 8 Gage, A. 49 Gold, M.S. 13, 19, 39 Foltin, R.W. 32, 35, 45 Gale, M. 82 Gold, P. 77 Fong, C. 57, 67, 78 Gale, M.C. 21 Gold, S. 2 Fong, T. 76 Galea, S. 39, 64 Goldberger, B.A. 19 Fonte, C. 24 Galizio, M. 62 Goldman, M. 47 Foord, C. 17 Galloway, G.P. 49 Goldsmith, J. 67 Ford, D. 56 Gallucci, G. 17 Goldsmith, R.J. 33 Forman, R.F. 39, 57, 66 Gandhi, D.H. 67 Goldston, D.B. 47 Forster, M.J. 14 Garawi, F. 18, 24, 35, 83 Goletiani, N.V. 23

89 AUTHOR INDEX

Golub, E.T. 65 Guenthner, G.E. 70 Hasin, D.S. 31, 33 Gonsai, K. 33, 83 Guerin, G.F. 14, 50 Haslam, R.R. 37 Gonzales, R. 47 Gulley, J.M. 79 Hasselrot, U. 30 Gonzalez, G. 33, 83 Gunduz, O. 82 Hatsukami, D.K. 71, 72 Gooch, J. 16 Guo, C.J. 81 Haug, N. 37 Goode, J.L. 3, 16, 18 Gurevich, Y. 23 Haunert, L.A. 73 Goodman, A. 49 Gust, S. 6 Havard, A. 18 Goodwin, A.K. 28 Gutala, R. 24 Havens, J.R. 18, 39, 44, 68, Gordon, A.L. 37 Gutierrez Padilla, A. 36 74 Gordon, C. 57 Gwadz, M.A. 48 Hawke, J.M. 48 Gordon, D. 31, 79 Hay, J.L. 73 Gore, J.C. 9, 41 Haberek, R. 47, 48 Hayashi, T. 11 Gorelick, D.A. 11, 41, 53 Habeych, M. 15 Hayden, V. 34 Gottschalk, P.C. 41 Hackman, H. 72 Hayes, B.A. 68 Gottschall, A. 31 Haddox, J.D. 3, 39 Haynes, L.F. 8 Gouarier, L. 10, 65 Hagan, H. 6, 21, 64, 65 Hays, L.R. 76 Graap, K. 33 Hague, M.A. 63 Hazim, R. 52 Grabowski, J.G. 7, 33, 59, 69, Haig, G. 38 He, S. 5 73 Haile, C.N. 83 Hearn, W.L. 69 Graczyk, Z. 49 Hakun, J.G. 10, 47, 75 Heath, A.C. 79 Grady, J.J. 16 Halanych, J. 42 Heckman, C.J. 22, 54, 65 Graham, A. 39 Hall, E.A. 68 Hedden, S.L. 19 Grant, J.D. 31, 32, 43, 73 Hall, F.S. 21, 51 Heil, S.H. 37, 43 Grasing, K.W. 5 Hall, S. 16 Heinz, A.J. 8 Greemland, M. 3 Hall, W. 72 Heishman, S.J. 70 Green, A.I. 76 Haller, D.L. 72 Hellew, L. 22 Green, C.E. 34, 58, 59 Haller, V.L. 5 Henderson, M.J. 56 Green, K.M. 69 Hamann, S. 24 Herbeck, D.M. 56 Green, K.S. 48 Hambarsoomian, K. 15 Herin, D.V. 50 Green, M.R. 26 Hamer, D. 79 Herman, I. 3 Green, S. 57 Hamilton, J. 7 Hernandez, A. 3 Green, T.A. 11 Hamilton, M. 19 Hernandez, M.C. 41 Greenbaum, C. 47 Haney, M. 24, 32, 45, 76 Hernandez, R.J. 28 Greengard, P. 52 Hankins, G.D.V. 36, 37 Herning, R.I. 9, 10, 32, 41, Greenwald, M.K. 9, 73, 74 Hanner, J.A. 74 54, 59 Greenwell, L. 46 Hannigan, J.H. 38 Herrmann, N. 18 Greiner, E. 77 Hanselka, L.L. 22 Hess, L.S. 15, 66, 67, 71 Grella, C.E. 57 Harder, V.S. 43 Hewitt, J.K. 31 Griffin, M.L. 48 Harding, W.W. 13 Heyman, G.M. 75 Griffing, S. 40 Hardy, M. 40 Hidalgo, C.G. 34 Griffiths, R.R. 10, 38, 63 Harenski, K. 24 Hieronymus, T.L. 36 Grohman, K. 37 Harman, J.J. 66 Higgins, S.T. 37, 43, 52, 71 Gromov, I. 22 Harmon, A.C. 13 Highfield, D.A. 73 Gross, M. 9 Harrell, P. 47 Higuera, A. 30 Gross, S.M. 72 Harrer, J.M. 33 Hile, M. 67 Gruber, D. 72 Harrington, N.G. 40 Hillhouse, M.P. 46, 67 Gruber, S.A. 10, 42 Harris, L.S. 53 Hillier, A. 65 Grudzinskas, C. 27 Harrison, R.J. 31, 36 Hilton, J. 76 Grunberg, N.E. 59 Harrod, S.B. 30 Hines, R.D. 34 Grundt, P. 77 Hart, C.L. 32, 45 Hiott, F.B. 9 Guarino, H. 21 Hart, S.L. 68

90 AUTHOR INDEX

Ho, A. 13, 23, 50, 52, Ingersoll, K.S. 22, 48, 54, 65 Kaiko, R.F. 76 79 Ingram, F. 57 Kalechstein, A.D. 33, 45, 59, 76 Ho, W.Z. 54, 81 Irvine, R.J. 29 Kalivas, P.W. 33 Hoffer, L.D. 37, 40 Ishiguro, H. 53 Kaltenbach, K. 37, 61 Hofflich, H.L. 23, 79 Ishikawa, Y. 50 Kamien, J.B. 43, 74 Hoffman, J. 67, 71 Itzhak, Y. 3, 11 Kaminer, Y. 47, 48 Hohl, C.A. 56 Izenwasser, S. 58 Kaminski, B.J. 22 Hollander, J.A. 51 Kamlet, J.D. 17 Holmes, T. 76 Jaanimägi, U. 12, 35 Kamon, J.L. 8, 78 Holtzman, S.G. 12, 13 Jackson, B. 45 Kampman, K.M. 60 Hooper-Wood, C. 76 Jackson, J.L. 12 Kandler, U. 58 Hoot, M. 80 Jacob, T. 31, 32 Kantak, K.M. 49, 51 Hope, B. 53 Jacobsen, L.K. 58 Kapadia, F. 6 Hopper, J.W. 35 Jacuzzi, N. 37 Kaplan, G.B. 5, 80 Horton, A.M. 18 Jaehne, E.J. 29 Karper, P.E. 12 Horvatich, P.K. 66 Jaffe, C. 46 Karunaratne, N. 36 Houck, P. 35 Jaffe, J.H. 67, 73 Katner, S.N. 3, 49 Houtsmuller, E. 22 Jager, G. 58 Katz, E.C. 40, 57, 67 Howard, J.L. 49, 62 Jagoda, E. 77 Katz, E.S. 23 Howell, L.L. 5, 12 Jagsch, R. 72 Katz, J.L. 77 Hser, Y.I. 40, 46, 49, 56, Jain, R. 53 Katz, N. 27, 40 57 Janis, I.B. 74 Katze, M.G. 82 Hsiao, C.K. 70 Janisse, J.J. 56 Kaufman, M.J. 1, 9, 10 Hsin, L.W. 77 Jasinski, D. 76 Kaul, L. 36 Hsiung, H.M. 5 Jassen, A.K. 5 Kayman, D. 57 Hu, S. 31 Jaszyna-Gasior, M.J. 70 Kaynak, O. 57 Huang, D. 49, 57 Jatlow, P.I. 24, 83 Keating, M. 56 Huang, Y. 40 Jeanty, Y. 55 Keeler, M.A. 29 Hubbard, R. 8 Jenab, S. 29, 52 Kehoe, P. 50 Hudecz, F. 82 Jennings, J.M. 72 Kellogg, S. 31 Huettner, S. 18, 74 Jensen, E. 9 Kelly, M. 29 Huey, M.P. 8 Jiang, H. 79 Kelly, T.H. 40, 46, 70 Hughes, A.A. 38, 39 Jimenez, M.J. 34 Kelly, T.M. 80 Hulley, S.B. 4 Jiménez, L. 66 Kemen, L.M. 29 Hulse, G.K. 55 Johanson, C.E. 1, 3, 32, 46, Kertesz, S.G. 4, 34, 42, 43 Hunt, T. 38 59 Kerwin, M.L. 67 Hunter, D. 29 Johnson, B. 55 Kessler, F.H. 55, 66 Hurt, H. 47 Johnson, B.T. 66 Ketterlinus, R.D. 15 Hurtig, L. 15, 67 Johnson, J.A. 8, 39, 56 Keyler, D.E. 24 Husbands, S.M. 14, 77 Johnson, M.W. 38 Keyser-Marcus, L.A. 37, 56, 66 Huynh, J. 79 Johnson, R.E. 53 Kidorf, M.S. 34, 36, 73, 74 Hwang, J. 9, 11, 45 Jones, H.E. 22, 74 Kiefe, C.I. 4, 42 Hwang, Y. 24 Jones, J. 14 Kilby, S. 55 Hyman, S.M. 8 Joranson, D.E. 19 Killeen, T.K. 33 Jospitre, T. 40 Kilts, C. 24 Ialongo, N.S. 15, 59 Jung, M. 35 Kim, B.M. 77 Iguchi, M.Y. 81 Juon, H.S. 47 Kim, I. 77 Inciardi, J.A. 3, 16, 39, 55, Kim, J. 9, 11, 45 66, 68, 73 Kahler, C.W. 78 Kim, S.J. 10, 11, 45 Indlekofer, F. 58 Kahn, R. 75 Kim, Y. 22 Ingersoll, G. 73 Kahn, R.S. 58 Kim, Y.K. 11

91 AUTHOR INDEX

Kimmel, H.L. 5 Kreek, M.J. 12, 13, 14, 23, Ledgerwood, D.M. 34 Kindbom, K. 74 26, 31, 50, 52, 73, 79, 82 Lee, C.M. 70 King, G.R. 60 Krejci, J. 55 Lee, C.T. 31 King, R. 66 Krishna, V.A.S. 34 Lee, D. 77 King, S.D. 40, 57 Kritz, S. 67 Lee, H. 5 King, V.L. 17, 36, 73, 74 Krol, W.F. 49 Lee, I. 21, 66 Kinlock, T.W. 68 Kropp, F. 33 Lee, P.A. 4, 41, 43, 68, Kirby, K.C. 67 Krupitsky, E.M. 65 69 Kirisci, L. 15, 36, 80 Krupski, A. 57 Lee, T.H. 11, 50 Kirsten, A.J. 3, 49 Kuba, T. 29 Leimberger, J. 8 Kirtadze, I.K. 68 Kubiak, S.P. 4, 68 Leite-Morris, K.A. 5 Kissin, W.B. 55, 57 Kuhar, M.J. 5 Lejuez, C.W. 47, 48, 75, 78 Kleber, H. 73 Kuhn, C.M. 23, 30 Leonard, C.M. 53 Klein, C. 16 Kulaga, A. 66 Leonard, K. 37 Klein, E.D. 12 Kum-Nji, P. 37 Leri, F. 62 Klein, T.W. 53 Kuo, I. 58 Lerman, C.E. 59, 62 Kleinheider, J.R. 8, 34 Kurtz, S.P. 16, 18 Lerman, H. 3, 10 Kleykamp, B. 72 Kuzumaki, N. 13 LeSage, M.G. 24, 53 Kline, A. 39 Lescano, A. 72 Klufas, M.A. 5 LaBelle, C.T. 56 Lessem, J.M. 31 Knapp, B.I. 77 Labouvie, E. 57 Leukefeld, C.G. 39, 44, 55, 68, Knapp, C. 62 Lacadie, C. 12 75 Knealing, T.W. 69, 75 Lacadie, C.M. 41 Leventhal, A.M. 59 Knight, K. 8 Ladaga, B. 71 Levin, F.R. 18, 32, 35 Knudsen, H.K. 16, 39, 56 LaForge, K.S. 31, 79 Levine, B. 22 Knudson, I.M. 29 Lai, M. 13 Levine, R. 6 Ko, M.C. 5 Landry, M. 15, 66 Levitin, T. 26 Koch, A.L. 4, 41 Lane, D.R. 40 Lew-Ting, C.Y. 70 Koch, J.R. 68 Lane, J.D. 14 Lewis, B. 13 Kocsis, L. 82 Lane, S.D. 32, 38, 75 Lewis, J.W. 14, 77 Koek, W. 28, 63 Lanfranco, M.F. 51 Lewis, M.Q. 22, 54 Koester, S.K. 40 Lang, J.P. 65 Li, C.S.R. 12, 35 Kohman, R. 60 Langhorst, D. 32, 37 Li, J. 19 Kohrt, B.A. 75 Langleben, D.D. 42 Li, M.D. 24, 79 Kollins, S.H. 35 Lanier, M. 65 Li, Y. 81 Kolodner, K.B. 36, 49, 75 Lanza, S.T. 7 Liang, H. 9 Konaklieva, M.I. 51 LaRowe, S.D. 33, 59 Libby, A.M. 16, 70 Koob, G.F. 1, 42 Larson, E.B. 29 Libretto, S.V. 15, 67 Kopajtic, T. 77 Larson, M.J. 66 Licata, S.C. 74 Kornetsky, C. 1, 62 Latimer, W.W. 15, 48, 55, 70 Lieb, R. 58, 69 Kornstein, S. 37 Latka, M. 6, 65 Liebschutz, J. 43 Kosten, T.A. 33, 50, 83 Latkin, C.A. 74 Lieving, L.M. 32, 38, 75 Kosten, T.R. 12, 17, 33, 35, Latkin, C.L. 18 Liguori, A. 66 41, 71, 83 Laudenslager, M. 16 Lile, J.A. 46, 52, 76 Kouri, E. 9 Laudet, A.B. 27, 44, 57, 67 Lilly, C.J. 79 Kowalczyk, W.J. 9 Lavie, E. 21, 83 Lin, S. 83 Kraft, R. 10 Lawson, A.L. 48, 55 Linder, N. 15, 67 Kramer, E.D. 39, 40 Lay, C.C. 3, 49 Ling, W. 33, 46, 55, 56, Kraut-Becher, J.R. 21 Lazerow, A. 78 59, 82, 83 Krauter, K.S. 31 Le, C.T. 24 Linkovich-Kyle, T.L. 35 Lederer, K.M. 40 Lintzeris, N. 76

92 AUTHOR INDEX

Lioznov, D.A. 65 Madras, B.K. 5, 10, 77 Mastro, N.K. 41, 43 Listerud, J. 10, 18, 42 Madry, L. 40 Mateyoke-Scrivner, A. 44 Listwak, S. 77 Magalhaes, M. 65 Mathews, J.L. 82 Liu, G. 19 Magis, C. 66 Mathis, A. 57 Liu, J. 9 Magruder, K. 57 Matos, T.D. 67 Liu, Q.R. 53 Magura, S. 27, 57, 67, 78 Matson, P.A. 70 Liu, Y. 21, 50 Magyar, A. 82 Maurer, M.A. 19 Llewellyn, A. 34 Mahabir, M. 59 Maxwell, J.C. 34 Llosa, L. 19 Mahadeo, M. 75 Mayberg, H. 42 Llosa, T. 19 Mahadevan, A. 63 Mazar, N. 9 Lloyd, J.J. 18, 74 Mahajan, S.D. 54, 80 Mazerolle, L. 19 Lloyd-Travaglini, C. 43 Mahoney, III, J.J. 33 Mazlan, M. 65, 76 Lobodov, B. 67 Maier, W. 42 Mazure, C.M. 9 Lockhart, N. 32 Majewska, M.D. 49 Mazzella, S. 17 Loeb, P. 66 Makriyannis, A . 53 Mazzotti, G. 16 Lofwall, M.R. 63 Malcolm, R.J. 19, 33 McCabe, S.E. 39 Logan, T.K. 17, 44 Malcy, J.A. 73 McCance-Katz, E.F. 22, 54, 83 Lohman, K.L. 48 Maldonado-Molina, M.M. 78 McCann, M. 47 Lohman, M. 16 Malison, R.M. 12 McCarthy, E. 9 Loipl, R. 72 Malkerneker, U. 55 McCarty, D. 56 Lomas, L.M. 12 Malta, M. 19 McCaul, M.E. 8 London, E.D. 42, 45 Mancha, B.E. 15, 48, 70 McClernon, F.J. 9, 35 Lopatko, O.V. 37, 75 Mandell, W. 57 McCorquodale, D. 79 Lopez, R.G. 49 Mangefrida, B. 74 McCoy, C.B. 55 Lou, X.Y. 79 Mangrum, L.F. 17 McCrary, S.L. 16, 37 Lowen, S.B. 18 Mantsch, J.R. 21, 23 Mcculler, W.J. 67 Lowery, C.L. 4 Maple, A.M. 30 McCulloch, N. 80 Lu, Q. 77 Marcum, A. 15 McDougall, S.A. 12 Luckenbaugh, D. 71 Mardikian, P.N. 33 McDowell, D. 18 Lugo, Y. 3, 16, 18 Mariani, J.J. 32 McGovern, M.P. 35 Lukas, S.E. 9, 18, 35, 70 Marinelli-Casey, P. 46, 67 McGregor, C. 45 Lundahl, L.H. 32, 59 Maris, M. 76 McHale, L. 37 Lundell, S. 6 Marlowe, D.B. 4, 41, 43, 68, McKinney, A.P. 62 Luquero, E. 31 69 McLaughlin, J. 26 Lussier, J.P. 43 Marquez, K. 10, 47, 75 McLellan, A.T. 39, 68 Luther, E.J. 70, 71 Marsch, L.A. 21 McLeod, C.C. 55 Luzzo, C. 49 Marshall, J. 5 McMahon, L.R. 38, 63 Lyle, M.A. 13 Martell, B. 33, 83 McQueen, A. 30 Lynch, K. 21, 38 Martelle, J.L. 50 McQueen, K.A. 58, 73 Lynch, M.E. 37 Martin, B.R. 53, 63 McRae, A.L. 12, 35 Lynch, W.J. 5 Martin, C.A. 40, 46, 70 McSherry, F. 55 Lynskey, M.T. 43, 79 Martin, G. 70 MCTG Investigators 65 Lyoo, I.K. 9, 10, 11, 45 Martin, N.G. 79 McWilliams, S.B. 62 Martin, S.S. 39, 55, 68 Mechoulam, R. 10, 22 Ma, J.Z. 24, 79 Martin-Santos, R. 18 Meeks, C. 34 Maalouf, W.E. 15 Martinez, A. 37 Mehta, A.K. 28 MacDougall, M.R. 47, 75 Martins, S.S. 38, 39 Meisch, R.A. 73 MacKerell Jr., A.D. 77 Mash, D.C. 17, 69, 79 Meissler, Jr., J.J. 54 Mactutus, C.F. 30 Mason, B.J. 32 Melendez, J. 67 Madden, P.A.F. 79 Mason, J.L. 71 Melin, P. 10, 65 Madeja, C.L. 56 Masson, E. 18 Melker, R.J. 39

93 AUTHOR INDEX

Mello, M.T. 76 Mokri, A. 72 Navarro, H.A. 14, 49 Mello, N.K. 23, 29, 83 Moleko, A.G. 55 Nazarian, A. 12, 29, 52 Meloy, L.D. 37 Mongeon, J.A. 37, 43 Neal, A.P. 14 Meltzer, P.C. 77 Monteiro, M. 19 Neavins, T.M. 48 Menarde, J. 67 Monterosso, J.R. 42, 45 Needham, M. 69, 75 Mencl, W.E. 58 Montoya, I.D. 45, 53 Needle, P. 6 Mendelson, J.H. 23, 29 Moodley, V. 36 Negishi, M. 14 Mendoza-Baumgart, M.I. 72 Moody, D.E. 22 Negus, S.S. 12, 50, 62, 83 Mennis, J. 17 Moolchan, E.T. 15, 23, 59, 66, Neidert, L.A. 12 Menoyo, A. 31 67, 70, 71 Neill, D.B. 24 Menoyo, E. 17, 81 Mooney, M.E. 7, 33, 58, 59, Nekhayeva, I.A. 36, 37 Meozzi, P.A. 53 69 Nelson, E.C. 79 Meredith, C.W. 46 Moore, B.A. 55, 56, 76 Nemes, S. 66, 67, 71 Meredith, S.E. 72 Moore, D. 19 Nestler, E.J. 11 Merves, M.L. 19 Moore, T. 10 Nestor, L. 45, 76 Meshberg-Cohen, S. 32 Morales, C. 4 Neubig, R. 2 Messina, N.P. 68, 69 Moreira, R.I. 65 Neudahl, L. 46 Metcalf, M.D. 77 Morey, T.E. 13, 39 Neufeld, K.J. 17, 36, 73 Metsch, L.R. 55 Morgan, D. 21, 50 Neugebauer, N.M. 52, 53 Metzger, D.S. 21, 54, 65, 72, Morgan, T. 57 Neumark, Y. 65 81 Morgen, K. 44, 57 Neumeyer, J.L. 82 Meyer, S. 32 Morgenstern, J. 57 Nevid, J. 18 Meyers, R.J. 16 Morrow, C.E. 36 Newman, A.H. 50, 77, 83 Mezinskis, J.P. 33 Mouratidis, M. 71 Newman, J.L. 50 Mezzera, M.J. 34 Moyer, R.A. 13 Newton, T.F. 33, 45, 59, 75, Mezzich, A.C. 15 Muchowski, P. 57 76 Michaels, C.C. 12 Muhammad, E. 38 Nguyen, M. 75 Miguéns, M. 30 Mukherjee, K. 53 Nguyen, V. 46 Mikulich-Gilbertson, S.K. 16, 31, 70 Munly, K. 66, 67 Nic Dhonnchadha, B.Á. 50, 51 Milby, J.B. 34, 43 Munoz-Plaza, C. 64 Nicastri, S. 59 Miller, A. 31, 36, 40 Murnane, A.C. 12 Nickerson, L.D. 70 Miller, G.M 5 Murphy, S.A. 6 Nielsen, D.A. 31 Miller, L.L. 62 Murray, D.E. 10 Nierenberg, A.A. 18 Milliken, J. 21 Myers, J. 65 Nietert, P.J. 43 Mills, K.L. 80 Myers, L. 53 Niv, N. 46 Minerly, A.C.E. 29 Myracle, A.B. 59 Niyomchai, T. 29, 30 Minnes, S. 31, 36 Noe, C.E. 43 Mintzer, M.Z. 63 Nader, M.A. 10, 29, 50, 51, Nong, L. 53 Mitchell, A. 45 83 Norman, A.B. 66 Mitchell, E. 83 Nader, S.H. 10 Norwood, C. 78 Mitchell, T. 76 Nair, M.P.N. 54, 80 Norwood, W. 34 Mitchelson, J.K. 41 Nakamura, A. 13 Nouvion, S.O. 32, 38, 75 Miyagawa, K. 54 Nandi, A. 76 Nunes, E.V. 18, 31, 32, 33, Miyata, H. 52 Nanjo, K. 14 55, 83 Miyatake, M. 12, 13, 52, 54 Nanovskaya, T.N. 36, 37 Nunez, E. 72 Mizuo, K. 54 Napolitano, B. 32 Nyborg, H. 17 Moeller, F.G. 59, 73 Naranjo, C.A. 18 Moerschbaecher, J.M. 38 Nardine, T.M. 64 O'Brien, C.P. 10, 18, 38, 42, Moffett, M.C. 5 Narita, M. 11, 12, 13, 14, 47, 54, 81 Mohan, D. 53 52, 54 O'Brien, M.S. 47 Mojsiak, J. 75 Nathan, P.E. 17 O'Connell, D.J. 39, 68

94 AUTHOR INDEX

O'Connell, J.J. 56 Pauly, J.R. 30 Platt, D.M. 14, 21, 38, 50, O'Connor, P.G. 56 Payne, L. 16, 47, 78 74 O'Grady, K.E. 68, 73 Payne, T.J. 79 Pletcher, M.J. 4, 37, 42 O'Malley, S.S. 9, 17 Pearce, V. 65 Podolin, S.R. 37 O'Neil, G. 55 Pearson, V. 37 Polcin, D.L. 49 O'Neill, A.K. 5 Pechansky, F. 55, 66 Poling, J. 33, 71, 83 O'Toole, T.P. 56 Peck, J. 46 Pollack, M.H. 18 Obando, C.P. 78 Pei, W. 36 Pollard, G.T. 49, 62 Obert, J.L. 47 Peirce, J.M. 17, 34, 43, 73, Pollini, R.A. 56, 65 Ode, J. 15 74 Pomm, R. 39 Oh, J.S. 10, 11, 45 Peleg-Oren, N. 15 Ponyatov, O.V. 71 Olbrisch, M.E. 72 Peles, E. 73 Pope, H.G. 10 Olds, T. 48 Pelletier, L. 66 Popik, P. 41 Oliveto, A. 1, 33, 60, 83 Penetar, D. 9 Poropatich, R. 35 Omar, H.A. 70 Pentel, P.R. 4, 24, 37, 53 Porrino, L.J. 10, 51 Ompad, D.C. 39, 64 Pereira Do Carmo, G. 60 Porter, B.D. 23 Onaivi, E.S. 53 Perez, M.J. 40 Postle, G.J. 39, 68 Ondersma, S.J. 19, 36, 56 Perez de los Cobos, J.C. 4, 31, 40, 41 Potenza, M.N. 41 Oosterhuis, B.E. 14 Perhach, J. 49 Potter, J.S. 74 Ordorica, P. 55 Perkins, I. 53 Poudevida, S. 18, 81 Orenstein, J.M. 9 Perkins, K.A. 24, 71 Poutet, R. 21 Orlando, M. 57 Perkins, M. 27 Pratt, R. 14 Ornoy, A. 47 Perkonigg, A. 69 Prendergast, M.L. 68, 69 Orton, H.D. 16, 70 Perlis, T. 21 Preston, K.L. 8, 11, 53 Orwin, R.G. 57 Perna, M.K. 30 Prestopnik, J.L. 16 Oser, C.B. 39, 44, 68 Perrine, S.A. 80 Price, R.K. 81 Ostacher, M. 18 Perry, B. 37 Primm, B.J. 40 Otiashvili, D.O. 19 Perry, E. 9 Prisinzano, T.E. 13, 26 Ott, J. 79 Perry, J.L. 29 Proudnikov, D. 79 Otto, M.W. 18 Person, S. 42 Pugh, K.R. 58 Ovezova, G.K. 71 Peters, E. 9 Peterson, A. 25 Quello, S.B. 32 Pablo, J.P. 69, 79 Peterson, P.K. 31 Quin, Y. 79 Pacifici, R. 81 Peterson, P.L. 78 Quiñones, E.I. 67 Paddock, S. 57 Petry, N.M. 34 Quinones-Jenab, V. 29, 30, 52 Pade, P . 22, 83 Pettinati, H.M. 7, 60 Padilla, M. 24 Phillips, T.J. 61 Rabin, R.A. 29 Page, B. 17 Piazza, M. 72 Raby, W.N. 18 Palamarchouk, V. 51 Picciotto, M. 25 Raehal, K.M. 80 Paliwal, P. 8 Pichini, S. 17, 81 Rahav, G. 15 Palmer, R.S. 17 Pickens, R.W. 68 Raiff, B.R. 71 Pantalon, M.V. 17, 56 Picker, M.J. 12 Rainey, P.M. 22 Parikh, M. 80 Pickworth, W.B. 23, 59 Raisch, D. 55 Park, A. 42 Piechatzek, M. 58 Ralph, R.J. 21 Park, S. 9 Pierce, R.C. 83 Ramchand, R. 59 Paronis, C.A. 50 Pilkonis, P.A. 36 Ramirez, R.R. 78 Parylak, S.L. 30 Pillay, S.S. 10 Ramsey, N.F. 58 Patapis, N.S. 66 Pimentel, P.J. 10, 42 Randall-Thompson, J.F. 21, 51 Patel, S. 53 Pintello, D. 44 Rapp, C. 74 Patterson, T.L. 66 Pitman, R. 9 Rathner, J.C. 56 Paulson, A.M. 75 Pkhovelishvili, I.P. 19

95 AUTHOR INDEX

Rawson, R.A. 8, 46, 47, 59, Robinson, S.E. 24 Russo, S.J. 29, 30, 52 65, 67 Robles, R.R. 67, 75 Rutter, J.L. 3, 62 Raymond, K.M. 31 Roddy, J. 4, 74 Razdan, R.K. 63 Rodolico, J.M. 9, 70 Sacco, K.A. 24 Rebec, G.V. 3 Rodriguez, J. 34 Sachs, G.S. 18 Reboussin, B.A. 10, 48 Rodríguez, C.R. 67 Sacks, J.Y. 19 Reece, A.S. 55 Roehrs, T. 3 Sage, R.E. 40, 66 Reed, B. 14 Roesch, M.R. 51 Saitz, R. 43 Reed, P.L. 49 Rogers, J. 53 Sajan, M. 23 Reiber, C. 43, 74 Rogers, T.J. 54 Sakai, J.T. 31 Reich, W. 37 Roget, N.A. 66 Saladin, M.E. 12, 33, 35, 59 Reichel, C.M. 12 Rogowska, J. 10, 42 Salazar, F. 72 Reid-Quiñones, K. 32, 37 Rohan, M. 9, 10 Salazar Reyna, J. 66 Reisinger, H.S. 58, 72 Rohsenow, D. 80 Salem, A. 29 Reissig, C.J. 29 Roiko, S.A. 24 Salinas-Stefanón, E.M. 38 Remillard, A.M. 71 Rojas, V.C. 48, 70 Salloum, I.M. 18, 80 Rengert, G. 17 Roll, J. 43 Salstrom, S. 12 Renshaw, P.F. 9, 10, 11, 45 Roll, J.M. 68 Samet, J.H. 43, 56 Reutenauer, E. 24 Roma, P.G. 29, 74 Samiy, T.S. 43, 74 Reynolds, B. 38 Roman, P.M. 7, 8, 16, 39, Sanchez, H. 14 Reynolds, J.L. 54 56 Sanchez, M.M. 12 Reynolds, M. 15 Ronai, A.Z. 82 Sanchez, O. 17 Rhoades, H.M. 34, 59, 69, 73 Ronen, A. 22 Sanci, V. 18 Rhodes, J. 47 Rorrer, W.K. 63 Sandler, A.M. 50, 51 Rhule, D.M. 78 Rose, J.E. 9 Sands, B. 44, 57 Rice, C. 15 Rosenblum, A. 57, 67, 78 Sannerud, C.A. 68 Rice, K. 77 Rosenthal, R.N. 49 Santa Ana, E.J. 43 Richards, B.D. 63 Ross, J. 18, 76 Santa Ana, L. 12 Richards, J.B. 38 Ross, J.D. 51 Santis, R. 34 Richardson, J.M. 56 Ross, J.T. 50 Sarasvita, R. 40 Richter, K.P. 2 Roth, M.D. 81 Saria, A. 13 Ricketts, E.P. 18, 74 Roth, M.E. 29 Sarma, P.V.V.S. 22 Ridenour, T.A. 31, 36, 37, 40, Rothbard, A.B. 72 Satayathum, S. 31, 36 78 Rothbaum, B.O. 33 Sawyer, C. 74 Rieckmann, T. 56, 66 Rothenberg, J.L. 55 Saxon, A. 55 Riggs, P.D. 16, 70 Rothman, R.B. 2, 3, 13, 29, Saxon, A.J. 46, 73 Riley, A.L. 14, 21, 29, 49, 77, 83 Sayre, S.L. 33, 34, 58 51, 62, 74 Rothstein, S. 15 Scheier, L.M. 16 Ríos-Bedoya, C.F. 15, 16, 47, 48, Rotrosen, J. 57, 67 Schein, J. 40 49, 78 Rounsaville, B.J. 17, 41 Scherrer, J.F. 31, 32, 43, 73 Risser, D. 72 Rouse, C. 73 Schild, H.H. 42 Roache, J.D. 60, 75, 76 Rowe, C.L. 58 Schildberg, F. 42 Robbins, G. 46 Rowlett, J.K. 1, 14, 21, 38, Schindler, C.W. 49 Robbins, M.S. 15 50, 74 Schlussman, S.D. 13, 50, 52, 79 Robbins, T. 1 Rubin, E. 18 Schmidt, W.K. 27 Roberts, D.C.S. 21, 50 Rugh, D. 15, 19 Schmitz, J.M. 7, 33, 58, 59, Roberts, M. 34 Ruiz, R. 48 69, 73 Robertson, A.A. 21 Ruiz, S. 34 Schnoll, S.H. 38, 39 Robin, N. 71 Runyon, S.P. 14 Schoenbaum, G. 51 Robinson, J. 67 Rush, A.J. 46 Schoeneberger, M.L. 19 Robinson, R. 40, 57 Rush, C.R. 46, 52, 76 Schoener, E.P. 56

96 AUTHOR INDEX

Schoeny, M. 10 Shindo, K. 13, 52 Song, L. 54 Schottenfeld, R.S. 17, 22, 55, 56, Shoaib, M. 20, 53 Sonne, S.C. 80 65, 72, 73, 76 Sholar, M.B. 23 Sonnefeld, J. 55 Schramm-Sapyta, N.L. 23 Shoptaw, S. 19, 46, 60 Sorensen, J.L. 7 Schreiber, S. 3 Shrestha, A. 48 Soto, J.M. 9 Schroder, C.M. 59 Shuhart, M. 82 Soto, M. 75 Schroeder, J.R. 53 Siderovski, D. 2 Souza-Formigoni, M.L.O. 76 Schrott, L.M. 23 Sidney, S. 4 Spadola, C.E. 72, 73 Schubiner, H. 32 Siegel, A.J. 23 Spaller, M.R. 5 Schuetz, C.G. 58 Sigmon, S.C. 10, 44 Sparkman, N.L. 60 Schumacher, J.E. 22, 34, 42, 43 Sikirica, V. 40 Spealman, R.D. 14, 20, 21, 50 Schumacher, M. 44, 75 Silowash, R. 35 Spear, S. 49 Schuster, C.R. 23, 25, 36 Silva, E. 55 Speck, K.J. 19 Schütz, C.G. 42 Silverman, K. 49, 69, 75 Spence, R.T. 17, 58 Schwartz, R.P. 40, 45, 57, 73 Silvers, J.M. 30 Spencer, T. 10 Schwartz, S.A. 54, 80 Sim, M.Y. 9, 11 Spiga, R. 17 Schweinsburg, A.D. 42 Simeone, A. 32 Spivey, R.J. 27 Sciortino, N.E. 10, 42 Simoes, A.A. 65 Sproule, B.A. 4, 18 Scoggins, K.L. 80 Simon, N.M. 18 Srisurapanont, M. 45 Scott, C.K. 57, 69 Simon, S.L. 59 St. Peter, J. 24 Scott Tonigan, J. 27 Simpson, D.D. 8 Stacey, H. 37 Sears, E.A. 68 Simpson, G.R. 49 Stahler, G. 17 Segarra, A.C. 9 Singer, L.T. 31, 36 Staines Orozco, H. 66 Segura, J. 81 Sinha, R. 8, 12, 35 Stairs, D.J. 12 Segura, M. 17 Siñol, N. 31 Staley, J.K. 9, 84 Seibyl, J.P. 9 Sipos, F. 82 Stallings, M.C. 31 Seitz, P.K. 51 Sircar, R. 63 Stalnaker, T.A. 51 Selby, P. 18, 59, 61 Skinner, J. 78 Stanger, C. 8 Seligman, K. 35 Skinstad, A.H. 17, 19, 66 Stanick, V.A. 44, 57 Selley, D.E. 63 Skivis, D. 37 Stanton, A. 25, 55 Semple, S.J. 66 Skudlarski, P. 12, 41 Stasiewicz, P.R. 35 Sen, M. 5 Slaymaker, V. 46 Statham, D.J. 79 Senay, E.C. 39 Slesnick, N. 16 Staton Tindall, M. 44, 68, 75 Sensenig, A.E. 12, 35 Slutske, W.S. 79 Stein, J.B. 7 Sepulveda, A. 37 Smiley-McDonald, H. 44 Steinberg, M. 55 Severtson, S.G. 55 Smith, C.S. 82 Steinberg, M.A. 41 Sevy, S. 32 Smith, E. 65 Steinmiller, C.L. 9 Shafer, S.S. 59 Smith, F.L. 63, 80, 82 Stepanenco, O. 67 Shahbazi, M. 30 Smith, H.R. 51 Stephens, R.S. 77 Shane, P.A. 28 Smith, K.J. 30 Stetler, G.L. 31 Shank, E.J. 49 Smith, L. 21, 66 Stevenson, G.W. 62 Shannon, L. 17 Smith, M.A. 13 Stevenson, R. 48 Shapiro, B. 37 Smith, M.Y. 3, 39 Stewart, J. 76 Sharpe Potter, J. 57 Smith, P.A. 82 Stewart, S. 24 Sheahan, F. 24 Smolen, A. 31 Stiffman, A. 14 Shear, K. 35 Sniderman, S. 37 Stine, S.M. 23 Shelton, R. 9 Sofuoglu, M. 33, 71, 83 Stitzer, M.L. 33, 43, 47, 56, Sherwood, T.A. 53 Solomon, L.J. 37 68, 71, 74 Shibasaki, M. 13 Somogyi, A.A. 73, 75, 82 Stoffel, E.C. 51 Shih, R. 15 Somoza, E.C. 33, 60 Stolerman, I.P. 1, 20 Shinar, D. 22 Song, I.C. 45 Stolinski, A. 24

97 AUTHOR INDEX

Stoller, K.B. 17, 73 Tamagnan, G.D. 9, 21 Toro, L. 34 Stone, A.L. 15, 16 Tanaka, T. 11 Toro-Guerrero, J. 14 Stoops, W.W. 46, 52, 76 Tancer, M. 3, 59 Torrens, M. 17, 18 Storr, C.L. 42, 47, 49, 70 Tancil, D.Y. 23 Torres, I. 30 Storti, S.A. 66 Tang, L.C. 21 Torres, R. 34 Stotts, A.L. 33, 34, 73 Tang, S. 13 Torres-Reveron, A. 30 Straits-Troster, K.A. 46 Tao, Q. 63 Torrington, M. 46 Strang, J. 76 Tapert, S.F. 42 Tortajada, S. 4, 40 Strathdee, L.A. 19, 36 Tarter, R.E. 15, 31, 36 Träber, F. 42 Strathdee, S.A. 6, 18, 19, 65, Tashkin, D.P. 81 Traynor, J.R. 2, 5, 14, 77 66, 74 Tatarsky, A. 25 Trujillo, K. 41 Strauss, S.M. 64 Tate, K. 9, 10, 32, 54, Trujols, J. 31 Streeter, C. 10 59 Tsai, S.Y. 11 Striley, C.L.W. 34 Taylor, J.R. 5 Tsibulsky, V.L. 66 Strobbe, S. 57 Taylor, S. 42 Tsoh, J.Y. 71 Strong Kinnaman, J.E. 17 Tcheremissine, O.V. 32, 38, 75 Tsoy, M.V. 65 Strupp, B.J. 30 Teesson, M. 18, 76 Tucker, J. 15 Sturm, K. 13 Teichman, M. 15 Turner, C.W. 15 Stutz, S.J. 49, 50 Tella, S.R. 68 Tuten, M. 22, 74 Su, T.P. 11, 31 Terlecki, M.A. 9 Tyler, F. 78 Subramaniam, G. 47 Termine, A. 24 Suess, P.E. 38 Terner, J.M. 12 Uhl, G.R. 21, 51, 53 Suh, J.J. 60 Terry, P. 32 Ulibarri, C.M. 12 Sullivan, L.E. 22, 54, 56 Teruya, C. 40, 56, 57 Umbricht, A. 33 Sullivan, M.A. 55 Tetrault, J. 54 Unterwald, E.M. 80 Sumner, J.E. 12 Thakur, G. 53 Upadhyaya, H.P. 2, 12, 35, 59 Sumpter, R. 66 Thase, M.E. 18, 80 Urschel III, H.C. 22 Sun, W. 29 Thatcher, D.L. 78 Sung, Y.H. 9, 10, 11, 45 Thatcher, L.N. 14 Vadhan, N.P. 32 Surratt, H.L. 16, 39, 55, 66, Thau, K. 6 Valderrama, J.C. 4, 40, 41 68, 72 Thingalaya, N.K. 54 Valdez, G.R. 50 Suzuki, M. 12 Thomas, D.A. 6 Vallow, S. 40 Suzuki, T. 11, 12, 13, 14, Thomas, M. 76 van den Brink, W. 58 52, 54 Thomas, M.L. 51 van Olphen, A. 53 Svenningsson, P. 52 Thompson, L.L. 16 van Ree, J.M. 58 Svikis, D.S. 32, 36, 37, 56, Thompson, W.S. 72 Vance, T. 32 66 Thomsen, M. 50 Vandelinde, N.J. 54 Swaney, M. 15 Thorner, E.D. 71 Vandrey, R.G. 69 Swann, A.C. 52 Thurstone, C. 16, 70 Vann, R.E. 24 Swieter, M. 26 Ticku, M.K. 28 Vansickel, A.R. 52, 76 Swift, R. 80 Tidey, J. 80 Vanyukov, M. 15 Sylvestre, D.L. 64 Tidgewell, K.J. 13 Vargas-Lopez, R. 36 Syvertsen, A.M. 37 Timberlake, D. 31 Vasilieva, N. 65 Szapocznik, J. 15 Tims, F.M. 28 Vastag, B. 1 Titus, J.C. 66 Vayhinger, B. 36 Tachkuliyeva, D.K. 71 Tkachenko, A.R. 49 Verduin, M.L. 35, 80 Taffe, M.A. 3, 49 Todorov, A. 43 Verendeev, A. 14 Tagliaferro, P.A. 53 Tolliver, J.M. 68 Verrico, C.D. 5 Taherinakhost, H. 72 Tomita, M. 54 Vessicchio, J.C. 24 Tai, B. 7 Torian, L.V. 21 Vicini, L.M. 12 Tait, R. 55 Tornatzky, W. 50 Vidal, A. 4, 40, 41

98 AUTHOR INDEX

Vietri, J. 10 Watson, D.W. 67 Wines, Jr., J.D. 72 Vikinsalo, M. 34, 43 Weaver, J.C. 72, 73 Winhusen, T.M. 33 Villalobos, G.C. 68, 71 Weaver, M.F. 68, 71, 72 Winsauer, P.J. 38 Villano, C.L. 67 Webster, J.M. 39, 44, 68, 75 Winter, J.C. 29 Visweswariah, H. 32 Wee, S. 51 Winters, K.C. 66 Viveros, M.P. 30 Weerts, E.M. 22, 28 Wisdom, J.P. 4 Vlahov, D. 39, 64 Weierstall, K.M. 29 Wisniewski, S.R. 18 Vlasova, N. 22 Weil, J. 67, 71 Witt, M. 74 Vo, H.T. 48 Weinberger, A.H. 24 Wittchen, H.U. 54, 58, 69 Vocci, F. 77 Weiner, J. 29 Wold, A.L. 70 Voet, H. 46 Weinstein, A.M. 3, 10 Wolfson, M. 48 Vogel, A.D. 65 Weinstein, H. 20 Wong, C. 43, 66, 74 Vogel, H. 67 Weintraub, E. 40, 57, 67 Wong, C.J. 49, 69, 75 Volkow, N.D. 1 Weiss, R.D. 18, 35, 74 Wong, D.F. 76 Von Diemen, L. 55, 66 Welch, M. 30 Woods, J.H. 5 Von Huben, S.N. 3, 49 Welch, S.P. 5 Woody, G.E. 25, 39, 46, 55, Vosburg, S.K. 32, 45 Wells, E.A. 78 65 Vuchinich, R.E. 34, 43 Wenger, G.R. 62 Woolson, R.F. 19 Wentland, M.P. 77 Woolverton, W.L. 1, 51 Wagner, F.A. 42, 72 Wenzel, S. 15, 57 Wooters, T.E. 52 Wagner, F.P. 46 Westerveld, M. 58 Wright, K.A. 32 Wagner, J.P. 62 Wetesel, W.C. 50 Wright IV, C. 3, 39, 40, 76 Wagner, M. 42 Wethers, J. 21 Wu, C. 20 Wakonigg, G. 13 Wexler, B.E. 41 Wu, H. 28 Waldron, H.B. 15 White, A. 40 Wu, H.B.K. 29, 52 Waldrop, A.E. 12, 35 White, D.A. 13 Wu, Y. 19 Walker, A. 65 White, J.M. 37, 45, 73, 75, Wu, Z.H. 16 Walker, C. 46 82 Walker, D.J. 37 White, L. 46 Xu, H. 13, 29 Walker, Q.D. 23, 30 White, W.L. 27, 57 Xu, J. 42, 45 Walker, R. 17 Whitmore, E.A. 70 Xu, M. 23 Walker-Smith, K. 67 Whittaker, K.M. 81 Xue, L. 36 Wallace, C.L. 75, 76 Wibisono, S. 65 Wallace, D. 34, 43 Wibowo, A. 65 Yanagita, T. 52 Wallis, A.B. 17 Wickes, W. 45 Yanasak, E. 46 Wallisch, L.S. 17, 58 Wilber, M.K. 41 Yancoviitz, S. 21 Walsh, R. 55 Willenbring, M.L. 82 Yang, J.C. 57 Walsh, S.L. 33, 44 Willhite, R. 10 Yang, P.B. 52 Walton-Moss, B.J. 8 Williams, A.D. 36 Yang, X. 19, 46, 77 Wang, J. 13, 24, 42 Williams, I.A. 77 Ye, W. 76 Wang, J.B. 77 Williams, K. 38 Yeom, C. 77 Wang, J.J. 18 Williams, K.L. 22 Yi, R. 74 Wang, S. 31 Williams, L. 74 Yin, W. 22 Wang, X. 13, 29, 54, 81 Williams, T. 31 Yondorf, M. 53 Wang, Y. 42 Williams, T.J. 57 Young, A.M. 13 Wang, Y.C. 70 Williams, Y.D. 52 Young, R. 3 Wang, Y.J. 81 Williamson, A.B. 76 Young, S. 16, 83 Wang, Z. 42 Williford, W. 55 Young, S.E. 31 Ward, S.J. 63 Wilson, A.S. 24 Yu, E. 38 Waterman, B. 31, 32 Wilson, J.C. 71 Yu, M. 14 Waters, A.J. 59 Wilson, N.M. 9, 59 Yuferov, V. 31

99 AUTHOR INDEX

Yurgelun-Todd, D.A. 10, 42 Zack, M. 59 Zack, S. 67 Zack, S.L. 71 Zacny, J.P. 40 Zagdyn, Z.M. 65 Zahniser, N.R. 79 Zalman, M. 39, 40 Zarza, M.J. 48 Zavela, K.J. 48 Zawertailo, L. 42, 59 Zernig, G. 13 Zhang, F. 13 Zhang, H. 8 Zhang, J. 23 Zhang, Q. 19 Zhang, T. 54, 81 Zhang, X. 11, 50 Zhang, X.Y. 50, 83 Zhang, Y. 13, 50, 52 Zhang, Z. 53, 57 Zharikova, O.L. 36 Zheng, F. 77 Zheng, G. 77 Zhou, H. 81 Zhou, L. 29 Zhou, W. 13 Zhou, Y. 23, 79 Zhu, H. 13 Zhu, J. 24, 52 Ziedonis, D. 55 Ziedonis, D.M. 2 Zielstroff, M. 9, 53 Zimmerman, D. 13 Zimmerman, R.S. 40 Zimmermann, P. 69 Zinn, L.F. 40 Zinzow, H. 12 Zolkowska, D. 3 Zorina, Y.A. 65 Zubritsky, E. 64 Zuccaro, P.G. 81 Zuckoff, A. 35 Zuo, C. 9 Zurabashvili, D.Z. 68 Zvartau, E.E. 65 Zvolensky, M.J. 78

100

The following organizations have generously supported the work of the College on Problems of Drug Dependence during the past year:

Alexza

American Psychological Association

Centre De Recherche Pierre Fabre

Dov Pharmaceuticals

Endo

Glaxo Smith Kline

Gruenenthal

GW Pharma LTD

Johnson&Johnson

National Institute on Drug Abuse

Neurocrine

New River Pharmaceuticals

Pfizer

Purdue Pharma L.P.

RSA

Shire