BOARD OF DIRECTORS Warren K. Bickel, PhD, President William L. Dewey, PhD Chris-Ellyn Johanson, PhD, Past-President Nicholas E. Goeders, PhD Kathryn A. Cunningham, PhD, President-Elect Martin Y. Iguchi, PhD Dorothy K. Hatsukami, PhD, Treasurer Sari Izenwasser, PhD Leslie Amass, PhD Herbert D. Kleber, MD James C. Anthony, PhD Thomas R. Kosten, MD Nancy A. Ator, PhD Horace H. Loh, PhD Anna Rose Childress, PhD S. Stevens Negus, PhD Thomas J. Crowley, MD Sharon Walsh, PhD Samuel A. Deadwyler, PhD EXECUTIVE OFFICER Martin W. Adler, PhD SCIENTIFIC PROGRAM COMMITTEE Sharon Walsh, PhD, Chair Scott E. Lukas, PhD, Past-Chair Martin W. Adler, PhD, ex officio Ellen B. Geller, MA, ex officio Patrick Beardsley, PhD Richard Glennon, PhD Leonard Handelsman, MD Arthur Horton, EdD Sari Izenwasser, PhD Gary B. Kaplan, MD Anthony Liguori, PhD Edythe London, PhD Athina Markou, PhD S. Michael Owens, PhD Linda J. Porrino, PhD Andrew J. Saxon, MD Sandra Welch, PhD Saturday, June 18, 2005 PRE-MEETING SATELLITES The International Study Group Investigating Crown Hall Drugs as Reinforcers (ISGIDAR) Chaired by Michael A. Nader 5 th Annual Meeting Center for Substance Abuse Treatment (CSAT) Great Hall East Science to Services and Services to Science: The Identification and Adoption of Effective Practices for Substance Abuse Treatment Chaired by Karl D. White The 10th Annual NIDA International Forum on England Building International Research on Drug Abuse: Progress through Collaboration Chaired by Steven Gust Translating Basic Research from Neural, Behavioral, Ireland and Social Sciences to Prevention: Challenges and Opportunities Food, Drugs, Obesity and Addiction: Common Scotland C Neurobiologic Processes? Chaired by Nora D. Volkow and Joseph Frascella CPDD REGISTRATION Great Hall Assembly Saturday, June 18 1:30 PM - 5:30 PM Sunday, June 19 8:00 AM - 12:00 PM 2:00 PM - 5:30 PM Monday, June 20 8:00 AM - 1:00 PM 2:00 PM - 5:00 PM Tuesday, June 21 8:00 AM - 1:00 PM Wednesday, June 22 8:00 AM - 12:30 PM 2:00 PM - 5:00 PM Thursday, June 23 7:30 AM - 1:00 PM OPENING RECEPTION 7:00 – 9:00 PM (Cash Bar) Pool Area xii Sunday, June 19, 2005 Sunday, June 19, 2005 CSAT TRAVEL AWARDEES BREAKFAST Grosvenor Resort (By Invitation Only) 7:00 - 8:30 AM Plenary Session Great Hall 8:30 - 11:00 AM 8:30 Welcome Warren K. Bickel, President, CPDD 8:45 Report from the National Institute on Drug Abuse Nora D. Volkow, Director, NIDA 9:15 Presentation of the Meritorious Service Award to Ian P. Stolerman Introduction by Chris-Ellyn Johanson, 9:20 Presentation of the Media Award to Brian Vastag Introduction by Marc J. Kaufman, 9:25 Presentation of the Joseph Cochin Young Investigator Award to Thomas E. Eissenberg Introduction by Robert L. Balster, 9:30 Presentation of the Joseph Cochin Young Investigator Award to James K. Rowlett Introduction by William L. Woolverton, 9:35 Presentation of the Mentorship Award to Linda A. Dykstra Introduction by Alison Oliveto-Beaudoin, 9:40 Presentation of the Nathan B. Eddy Award to Conan Kornetsky Introduction by George F. Koob, 9:45 Nathan B. Eddy Award Lecture A walk through the history of drug abuse: Research, trends and fads Conan Kornetsky, Boston University School of Medicine, Boston, MA President’s Lecture Great Hall 1:00 - 2:00 PM COGNITIVE SEQUELAE OF DRUG ABUSE: STUDIES IN HUMANS AND EXPERIMENTAL ANIMALS Trevor Robbins University of Cambridge, UK 1 Sunday, June 19, 2005 Symposium I Scotland 2:00 - 4:00 PM DRUGS OF ABUSE AND REGULATORS OF G-PROTEIN SIGNALING Chairs: John Traynor and Richard Neubig 2:00 Just what are RGS proteins? David Siderovski, The University of North Carolina at Chapel Hill, Chapel Hill, NC 2:25 RGS protein modulation of abuse liability properties of opioids and stimulants John Traynor, University of Michigan Medical School, Ann Arbor, MI 2:50 Regulation of RGS proteins by drugs of abuse Stephen Gold, UT Southwestern Medical Center at Dallas, Dallas, TX 3:15 Inhibitors of RGS protein activity Richard Neubig, University of Michigan Medical School, Ann Arbor, MI 3:40 RGS proteins as targets for drug abuse treatment medications Discussant: Richard B. Rothman, NIH/NIDA Intramural Research Program, Baltimore, MD Symposium II England 2:00 - 4:00 PM NICOTINE DEPENDENCE AND PSYCHIATRIC DISORDERS: TREATMENT IMPLICATIONS Chairs: Ivan D. Montoya and Himanshu P. Upadhyaya 2:00 Biological determinants of nicotine dependence in severe mental disorders: Cognitive deficits and genetic polymorphisms as targets for therapeutics development Tony P. George, Yale University, Connecticut Mental Health Center, New Haven, CT 2:25 Treatment of nicotine dependence in individuals with schizophrenia Douglas M. Ziedonis, Robert Wood Johnson Medical School, Piscataway, NJ 2:50 Treatment of comorbid ADHD and nicotine dependence Himanshu P. Upadhyaya, Medical University of South Carolina, Charleston, SC 3:15 Current research and future directions for treating nicotine dependence among illicit drug users Kimber P. Richter, University of Kansas Medical Center, Kansas City, KS 3:40 Discussant Lirio S. Convey, Columbia University and New York State Psychiatric Institute, New York, NY 2 Sunday, June 19, 2005 Oral Communications I Crown Hall 2:00 - 4:00 PM MDMA: IS IT REALLY ECSTASY? Chairs: Richard A. Glennon and Chris-Ellyn Johanson 2:00 Pizotyline fully antagonizes the discriminative stimulus effects of MDMA R.A. Glennon and R. Young, Virginia Commonwealth University, Richmond, VA 2:15 Consequences of exposure to neurotoxic regimens of methamphetamine and MDMA (ecstasy) on cognitive paradigms in mice C. Achat-Mendes, S.F. Ali and Y. Itzhak, University of Miami School of Medicine, FL and NCTR, FDA, Jefferson, AR 2:30 3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) elicits context-dependent locomotor and electrophysiological sensitization in freely moving rats K.T. Ball, D. Budreau and G.V. Rebec, Indiana University, Bloomington, IN 2:45 Tolerance to behavioral and neuroendocrine effects of ecstasy (MDMA) in rats M.H. Baumann, F.H. Franken, J.J. Rutter, R.D. Clark and R.B. Rothman, NIH/NIDA Intramural Research Program, Baltimore, MD 3:00 Effects of ecstasy (MDMA) on plasma serotonin in rats: In vivo and in vitro evaluation D. Zolkowska, M.H. Baumann, R.D. Clark and R.B. Rothman, NIH/NIDA Intramural Research Program, Baltimore, MD 3:15 MDMA-induced hyperthermia in rhesus monkeys M.A. Taffe, S.N. Katner, C.C. Lay, S.N. Von Huben, R.D. Crean, S.A. Davis and A.J. Kirsten, The Scripps Research Institute, La Jolla, CA 3:30 The effects of MDMA on sleep architecture and subsequent mood in humans C.E. Johanson, T. Roehrs and M. Tancer, Wayne State University, Detroit, MI and Henry Ford Hospital, Detroit, MI 3:45 Striatal dopamine release during a motorbike riding computer game in novelty seekers and recreational ecstasy users in SPECT A.M. Weinstein, M. Greemland, H. Lerman, I. Herman, S. Schreiber, R. Bar-Hamburger and E. Even-Sapir, Sourasky Medical Center, Tel Aviv, Jaffa Treatment Center for Drug Victims, Israel and Israeli-Anti Drug Authority, Jerusalem, Israel Oral Communications II Ireland 2:00 - 3:00 PM MISUSED PRESCRIPTION DRUGS: CRUELLA DE PILL Chairs: James A. Inciardi and Curtis Wright 2:00 Trends in the diversion of prescription opioids in the United States J.A. Inciardi, A. Hernandez, J.L. Goode and Y. Lugo, University of Delaware, Center for Drug and Alcohol Studies, Coral Gables, FL 2:15 Characteristics of nonmedical users of hydromorphone: Results from the National Survey on Drug Use and Health J.D. Haddox, M.Y. Smith and C. Wright IV, Purdue Pharma L.P., Stamford, CT 3 Sunday, June 19, 2005 2:30 Characterizing controlled-release oxycodone abuse in a Canadian treatment facility B.A. Sproule, B. Brands and L. Catz-Biro, University of Toronto, Toronto, Canada 2:45 Antecedents of prescription opioid abuse in the CARDIA study M.J. Pletcher, S. Kertesz, S. Sidney, C.I. Kiefe and S.B. Hulley, University of California, San Francisco, CA, University of Alabama at Birmingham, AL and Kaiser Permanente Division of Research, Oakland, CA Oral Communications III Ireland 3:30 - 4:30 PM POLICY IN THE CLINIC AND COURTROOM Chairs: Cynthia L. Arfken and Jennifer P. Wisdom 3:30 Who provides specialized programs for criminal justice populations? C.L. Arfken, S.P. Kubiak, A. Koch and J. Roddy, Wayne State University, Detroit, MI 3:45 Substance-use patterns in drug court: No problem? D.S. DeMatteo, D.S. Festinger, P.A. Lee and D.B. Marlowe, Treatment Research Institute, Philadelphia, PA 4:00 Towards an agreement about evaluation instruments in health care units on drug abuse in the autonomous region of Valencia (Spain) C. Morales, A. Vidal, M. Castellano, P. De Vicente, J.C. Perez de los Cobos, R. Aleixandre, S. Tortajada and J.C. Valderrama, Instituto de Historia de la Ciencia y Documentación Lopez Piñero (UV-CSIC), FEPAD, Generalitat Valenciana and Hospital de la Santa Creu i Sant Pau, Valencia, Spain 4:15 Process improvement to increase access and retention: Real-world application in a women- focused substance abuse treatment agency J.P. Wisdom, E. Gifford, and N. Roget, Oregon Health and Science University, Portland, OR and Center for Health Care Evaluation, VA Palo Alto Health Care System, Palo Alto, and Stanford University School of Medicine, Stanford, CA Symposium III England 4:45 - 5:45 PM TREATMENT OF THE PREGNANT ADDICT: FROM THE LABORATORY TO THE CLINIC Chairs: Mahmoud S. Ahmed and Amrat Patel 4:45 Effects of a nicotine vaccine on nicotine transfer to the fetus in rats: A model of pharmacokinetic approaches at reducing fetal exposure to addictive drugs Paul Pentel, Hennepin County Medical Center, Minneapolis, MN 5:05 Noninvasive assessment of fetal brain activity Curtis L.