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Finding Better Treatments and a Cure for Recurrent Prostate Cancer: Winter 2004 Progress Report

• Detection, Diagnosis and Prognosis PCF-Funded Scientist Prostate Cancer Foundation of Prostate Cancer Aaron Ciechanover Releases Its First Annual Report • Local Treatment of Prostate Cancer • Androgen Deprivation Therapy Awarded Nobel Prize for Prostate Cancer to the Nation on Prostate Cancer The Prostate Cancer Foundation is pleased • Management of Bone Metastases to honor Aaron Ciechanover, M.D., winner in Patients with Prostate Cancer n addition to being the world’s leading source of philanthropic of the 2004 Nobel Prize in Chemistry and Isupport for prostate cancer research, the Prostate Cancer • Chemotherapeutic Options in a recipient of multiple research grants Patients with Prostate Cancer Foundation (PCF) is also one of the leading sources of information from the Prostate Cancer Foundation. • Emerging Therapies for Prostate Cancer about progress toward better treatments and a cure for recurrent The PCF has provided Dr. Ciechanover • Management of Side Effects in with research grants each year since 2000 prostate cancer and a leading force in accelerating that progress. Prostate Cancer Therapy to investigate the application of his research to the development of new therapies for • Nutrition and Prevention Strategies for prostate cancer. Dr. Ciechanover has On September 22, the Prostate Cancer to gain a clearer understanding of how to Prostate Cancer Foundation introduced a new publication work together to provide prostate cancer reported on these investigations at several designed to increase the base of knowledge patients with optimal care. The Report • Therapeutic Strategies for Patients with of the PCF’s annual Scientific Retreats, about prostate cancer: The Report to the also features important “calls to action” a Rising PSA: A Case-Based Approach including the 2004 Retreat held in October. Nation on Prostate Cancer. The Report for prostate cancer researchers to address Although the Report is primarily targeted The Nobel Foundation recognized is designed to increase knowledge among unanswered scientific questions and for to physicians, well-informed patients and Dr. Ciechanover’s work in illuminating physicians about leading approaches healthcare providers to focus on important caregivers may find the Report interesting the significance of the cellular machine to the treatment of prostate cancer. and valuable as well. issues related to disease management. called the proteasome, which regulates Supported by the PCF’s Pharmaceutical the destruction of unneeded cell proteins. Industry Roundtable, the Report provides Two world-renowned cancer researchers The Report is available online at www.prostatecancerfoundation.org and a comprehensive overview of the state- served as executive editors: Peter R. The proteasome is the target of the drug is being distributed in print to more than of-the-art in the diagnosis, treatment Carroll, M.D., professor and chair of the Velcade, which is approved for use in 20,000 physicians who treat patients and prevention of prostate cancer and Department of Urology at University of treating multiple myeloma and is being with prostate cancer. sets a clear research agenda for the future. California at San Francisco, and William tested for use in treating prostate cancer. G. Nelson, M.D., Ph.D., professor, The PCF has also provided crucial fund- With authors from a wide array of Following a media launch at the New Departments of Oncology, Urology, ing to support the clinical development specialties, the Report supports the concept York Academy of Sciences, a Continuing Pharmacology, Medicine and Pathology of Velcade. of a multidisciplinary approach to the Medical Education (CME)-certified live at The Johns Hopkins University. symposium was held, with more than management of prostate cancer. The PCF “The Prostate Cancer Foundation salutes 120 tristate area physicians in attendance. intends the Report to be used by all those Following an introduction by the execu- Dr. Aaron Ciechanover and congratulates An additional 300 physicians participated involved in the care of prostate cancer tive editors, the Report is comprised of him for winning the Nobel Prize in via a live webcast on Medscape.com patients—including urologists, medical nine chapters written by 22 prostate Chemistry. His discovery of the critical (the webcast will remain available at oncologists and radiation oncologists— cancer thought leaders. The chapters are: importance of the proteasome is crucial Medscape.com for one year), and in the to the development of new therapies for first week alone, more than 15,000 prostate cancer,” said Leslie D. Michelson, healthcare providers viewed the Report vice chairman and CEO of the Prostate chapters on the Medscape site. Each Cancer Foundation. “The PCF funded of the nine chapters of the Report are Dr. Ciechanover through its Israel also available as a CME activity on Initiative, which is part of our worldwide Medscape.com/prostatecancer. effort to harness the talents of the best The Report has already generated and brightest in the fight for better treat- significant media coverage from Time ments and a cure for recurrent prostate magazine, USA Today, NBC News, CBS cancer,” he added. News, the Washington Times, CNN.com, BusinessWeek Online and Health News Daily, among others. Inside This Issue The PCF gratefully acknowledges the support of Abbott Laboratories, Aventis, Novartis and Sanofi-Synthelabo, the founding members of the PCF’s From the CEO 2 Pharmaceutical Industry Roundtable, Board News 2 which supported this initiative and helped to defray the costs of producing the Report. Science Update 3 The content of the Report was developed Lifestyle 4 entirely by the Report’s authors with no Peter T. Scardino, M.D., chair of the Department of Urology and head of the prostate cancer editorial input from the members of the Recipe 5 program at Memorial Sloan-Kettering Cancer Center (left); Daniel P. Petrylak, M.D., associate Roundtable in any manner. professor of medicine at Columbia University College of Physicians & Surgeons (center); and News 6 –7 Peter R. Carroll, M.D., professor and chair, UCSF Department of Urology (right), answer questions at a media briefing regarding the PCF’s Report to the Nation on Prostate Cancer Events 7 held at the New York Academy of Sciences on September 22, 2004. Calendar 8 Leadership 8

1 www.prostatecancerfoundation.org 310.570.4700 PCF Announces New Amateur Tennis Program

The Pacific Life Open, an ATP Masters The tournaments are designed for men Open, complimentary hotel rooms, Series Event, has recently partnered with and women players who are members of invitations to both the Friday and Events the Prostate Cancer Foundation to launch a tennis club and have a maximum Saturday evening cocktail and dinner a new amateur doubles program, the National Tennis Rating Program (NTRP) parties, and credentials for the Pacific The PCF conducts and participates in Pacific Life Open Club Championships, rating of 4.0. Players can sign up at their Life Open. In addition, all winners of the many programs aimed at raising not to raise both awareness and funds for participating club as they would for any Pacific Life Open Club Championships only research funding but also public prostate cancer. club-run or -sponsored event. An entry will be recognized on Stadium Court awareness of prostate cancer. fee of $50 per participant ($100 per team) following the Men’s Singles Final of the As of October 2004, players from clubs covers both qualifying competition as Pacific Life Open. across Southern California will compete well as an all-expenses-covered weekend in 40 qualifying amateur club tournaments For more information, or to for each club champion at the Pacific Life for the right to advance and represent schedule a tournament at your Open Club Championships. their tennis club at the Pacific Life Open club, please email tennis program Club Championships, scheduled to be Winning players from each club will coordinator Jessica Niebauer at held during the final weekend of the receive gift certificates toward the [email protected]. Pacific Life Open, March 18 – 20, 2005. purchase of tickets to the Pacific Life

A Night to Remember New Yorkers Can Contribute PCF Home The Niebaum-Coppola Estate Winery in Napa Valley was the setting for to Prostate Cancer Research Run Challenge the 12th anniversary of Cigar Aficionado’s “A Night to Remember.” In total, the Through Tax Form Check-off 2004 evening raised close to $800,000 for prostate cancer research. From left to right: On August 3, 2004, New York Governor medical and research communities and George Pataki signed New York State other organizations in an effort to help Cigar Aficionado editor and publisher Senate Bill 6206A providing for the prevent prostate cancer and save lives. Marvin R. Shanken and his wife, Hazel; new prostate cancer state tax check-off. All New Yorkers owe a debt of gratitude former actress Janet Jones-Gretzky; Beginning with their 2004 tax returns, to Mike Milken for his dedication and Niebaum-Coppola winery owner Francis New Yorkers can now contribute to commitment to this effort.” Ford Coppola; broadcaster Rush prostate cancer research by simply check- Limbaugh; Hall of Fame hockey legend ing off a donation of any amount on their Beginning with their 2004 tax state tax returns. For every dollar Wayne Gretzky; and PCF chairman returns, New Yorkers can now contributed by the taxpayers, the State Michael Milken. , manager of the , of New York and the Prostate Cancer contribute to prostate cancer joins fellow prostate cancer survivor and Foundation have agreed to donate a dollar, research by simply checking PCF chairman Mike Milken in donning so that every dollar donated becomes blue wristbands in support of the 8th three dollars for prostate cancer research. off a donation of any amount Annual Challenge. This game, The impetus for this bill began at the on their state tax returns. between the Cubs and Astros, was held New York State Roundtable on Prostate at Park in , , Cancer, a meeting of the state’s leading These contributions will be placed in a and was one of 60 designated games cancer experts co-hosted by PCF founder 501(c)(3), the New York Coalition to during Home Run Challenge week. and chairman Mike Milken and New Cure Prostate Cancer, which is dedicated York State Senate Majority Leader Joseph solely to this cause. An independent panel When it comes to raising money to fight Bruno, both prostate cancer survivors. comprised of the top prostate cancer prostate cancer, the Prostate Cancer On the day of the signing, Senator Bruno research scientists will then distribute Foundation has been hitting them out of March 20–21, 2004— said, “I thank Governor George Pataki these funds through a competitive awards the park with the Home Run Challenge 3rd Annual Indian Wells and Assembly Speaker Sheldon Silver for process to research centers throughout (HRC). Now in its eighth year, the PCF Pro-Am Tennis Tournament partnering with the Senate on this critical the State of New York conducting the 2004 Home Run Challenge has teamed Players from across the country paired legislation to unify and harness the most promising research to find better with Major League and the together to help raise money in the fight efforts, energies and resources of the treatments and a cure for prostate cancer. Players Association against prostate cancer at the 3rd Annual in a nationwide slugfest that has raised more than $2 million to fund prostate Indian Wells Pro-Am Tennis Tournament. cancer research. From left to right: Hall of Fame hockey legend and tournament champion Wayne Baseball fans everywhere had the oppor- tunity to pledge money for each home Gretzky, businessman Dennis Washington, run hit in 60 preselected games beginning former number four world-ranked tennis on June 11, and ending on Father’s Day, player and tournament champion Jonas June 20. With 132 total home runs hit, Bjorkman and PCF founder and chairman this summer’s HRC sluggers have outdone Mike Milken all participated in the Pro-Am themselves. Tennis Tournament. Dave Perron, managing director of the HRC, still has the enthusiasm of a rookie who has been sent up to the Big Leagues.

“We have participation from every asset of the game, from management to labor—all the owners, the team executives, front office personnel, even the groundskeepers support our work. PCF chairman Mike Milken (third from left) and PCF vice chairman and CEO Leslie D. Every year this great effort is the result Michelson (center) look on as New York Governor George E. Pataki (seated) signs into law of the collaboration of several equally legislation that will create a voluntary check-off box on New York State income tax forms. important elements: the number of Drive for the Cure For every dollar contributed by the taxpayers, the State of New York and the Prostate Cancer donors we get, the level of participation John Nordstrom, actor Hal Linden and Foundation have each agreed to donate a dollar, so that every dollar donated becomes from the general public, and of course, Stan Maron attended the PCF’s Drive for three dollars for prostate cancer research. the number of home runs hit.” the Cure in Cabo San Lucas, .

7 www.prostatecancerfoundation.org 310.570.4700