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SFBR Progress Spring-Summer 2008 Evestra Inc SFBRSFBR A Publication of the Southwest Foundation for Biomedical Research Spring-Summer Issue 2008 Inside NBAF could be a game changer for San Antonio. Page 7 • Do cures already exist for Ebola, other threats? Page 11 Study findings help explain why our sense of thirst declines with age. Page 13 • Spotlight on Dr. Thomas Folks. Page 18 Researchers learning how genes influence diabetes risk. Page 15 • Interview with Trustee J. Burleson Smith. Page 23 Message from the President John C. Kerr In its own version of Back to the local organizations, including SFBR, San Antonio Future, this issue of Progress takes readers on is a strong contender among the five U.S. cities a thrilling journey, as we see how the that remain in competition for the NBAF. In fact, Foundation’s rich history and the efforts of SFBR’s unique experience and expertise in various individuals over previous decades have maximum-containment research is something enabled the scientific success we’re enjoying that sets San Antonio apart from its competitors. today, and how they’ve positioned the SFBR is happy to be a major supporter of the Foundation and the city of San Antonio for even local effort to win the NBAF, which if successful CONTENTS greater achievement in the future. would represent the single most important new SFBR launches its Consider Dr. P.N. Rao , who came to the development in a 20-year effort to promote the first spin-off company Foundation in 1958, when he and his colleagues biosciences in San Antonio. Organic Chemistry Department had to work in a farm building converted to Another extraordinary resource at SFBR has transfers to Evestra Inc. 3 laboratory space. With that rather shocking and its origins in the 1950s, when scientists first humbling start to his career here, he embraced discovered that the baboon was a natural model NBAF could be a game changer for San Antonio the bold vision of SFBR founder Tom Slick, with for the study of atherosclerosis and other aspects SFBR supports local efforts to win whom he quickly became friends, and became a of cardiovascular disease. Today, the Southwest federal laboratory 7 world leader in the field of steroid chemistry. National Primate Research Center is one of Today, he holds 17 patents in steroid hormone SFBR’s crown jewels, enabling innovative and Do cures already exist synthesis and immunoassay methodologies that groundbreaking studies by investigators at SFBR for Ebola, other threats? have had a marked impact on physicians’ abilities and around the world. It also has helped attract New project aims to find out 11 to diagnose and effectively treat reproductive luminary scientists to key positions at our Why our sense of thirst disorders and various forms of cancer. And at a organization, including Dr. Thomas Folks, who declines with age point in his career when most people would recently came to the SNPRC after a distinguished Study results offer insight 13 retire, he is playing a key role in the career at the Centers for Disease Control and Researchers learning establishment of SFBR’s first spin-off company, Prevention. Progress readers should enjoy learning how genes influence Evestra Inc. about his outstanding accomplishments in public diabetes risk With a highly impressive leadership team health efforts to detect and identify emerging Study looks at top 100 genes 15 that includes the former chief operating officer viruses and to prevent the spread of HIV. As you Spotlight on of ILEX Oncology, Dr. Ze’ev Shaked, Evestra is in do, you will see why we’re thrilled to have him as Dr. Thomas Folks fact being called by some “San Antonio’s next part of the SFBR team. Long-time CDC leader brings ILEX.” That remains to be seen, but as Evestra Other scientific highlights in this issue valuable expertise to SFBR 18 builds upon the accomplishments and expertise include the discovery by Dr. Robert Shade and Interview with Trustee of Drs. Rao, Shaked, and other key leaders, it has his local and international colleagues of the area J. Burleson Smith the potential to be an industry leader in the area of the brain that is responsible for a decreased A true cornerstone of Southwest of women’s health and cancer treatment, a great sense of thirst in the elderly – a finding that Foundation 23 financial investment for SFBR, its largest could lead to treatments that would renew a stakeholder, and a vital new component of San proper sense of thirst and decrease the risk of Partners in progress Antonio’s increasingly robust bioscience industry. dehydration among the elderly. And Dr. Joanne Support from Golden Circle, Southwest Foundation Forum, Another visionary idea embraced by SFBR Curran, a bright young scientist in our Genetics Founder’s Council and other trustees and donors in its recent history was the Department, is building upon previous findings donors advances SFBR’s mission construction of a state-of-the-art virology complex by her and several other SFBR scientists as she 27 that includes the nation’s only privately owned uses a new federal grant to look more closely at BSL-4 laboratory. This extraordinary resource has the top 100 genes that SFBR studies have shown allowed SFBR to develop world-class research to influence diabetes risk factors. programs in the areas of biodefense and Finally, I believe our readers will enjoy a trip emerging infectious diseases, including a new through SFBR history with J. Burleson “Burley” collaboration with SRI International to test Smith, who has served as a trustee nearly since existing FDA-approved drugs for the ability to the Foundation’s inception. After World War II, treat bio-threat agents. he returned to San Antonio to join a new law It’s also a vital resource in a citywide effort to firm that was the predecessor to today’s Cox bring the first major federal research laboratory Smith Matthews Inc., and in the process, became built in the last 50 years to San Antonio. The closely involved with the Slick family and the National Bio and Agro-Defense Facility, or NBAF, fledgling research institution founded by Tom will be a $450 million federal installation to Slick. As one of the cornerstones in our address national biological and agricultural foundation, Burley Smith knows from firsthand security risks, and it will be a boon to whichever experience just how far SFBR has come and the city is chosen to host it. potential we have for even greater achievements Thanks to the united effort of numerous in the future. 2 SFBR Progress Spring-Summer 2008 Evestra Inc. drug development Organic Chemistry Department, an internationally recognized research group in steroid chemistry, together with start-up venture built around life’s work funding from SFBR, which will initially be the majority of Senior Scientist P.N. Rao shareholder of the new company. In addition to funding provided by SFBR, Evestra is raising an initial round of financing primarily from San Antonio-area investors. hen Genzyme Corp. paid $1 billion for Evestra is being built on the department’s 30-plus years’ San Antonio-based ILEX Oncology in 2004, a experience in the discovery and synthesis of novel steroid longtime vision of many of the city’s business compounds used in a wide range of female healthcare and civic leaders was realized. Those who had applications, including contraception, gynecological diseases, long before dreamed of San Antonio becoming hormone replacement therapy, and hormone-dependent breast w a serious player in the cancer. bioscience business saw the Dr. P.N. Rao, the distinguished chair of big-dollar purchase of the homegrown the department, is teaming with Dr. Ze’ev ILEX, a spin-off of the Cancer Therapy & Shaked, the former chief operating officer Research Center in the mid-1990s, as a and head of R&D at ILEX, who will serve as major milestone. The city had, indeed, president and CEO of Evestra, and with stepped onto the world stage in a new and Dr. Klaus Nickisch, the former senior vice exciting way. president of Schering AG in Germany, who John Kerr, president of Southwest will serve as Evestra’s chief scientific officer. Foundation for Biomedical Research, is not suggesting such a Both Drs. Shaked and Nickisch hold Ph.D.s in Organic massive pay-off is in the offing, but he’s undeniably excited Chemistry. about SFBR launching its first spin-off company, Evestra Inc. By combining SFBR’s steroid synthesis capabilities with Here’s how Kerr, who first envisioned the Evestra concept, the extensive drug development track record of Evestra’s describes the new company: management, Evestra is commercializing a pipeline of products Incorporated in late 2007, Evestra is receiving all of the in fertility control, hormone replacement therapy, and oncology. assets, personnel, and scientific know-how of the Foundation’s ̈ Continued on page 4 SFBR Progress Spring-Summer 2008 3 Evestra, continued from page 3 house development of novel steroidal drugs based on the “Over the past 50 years at SFBR, Dr. P.N. Rao has been one expertise of its organic chemistry team. of the world’s foremost experts on steroid chemistry and The leading drug candidate, a reformulated oral women’s fertility and cancer,” said Kerr. Dr. Rao, who became contraceptive, involves seeking an accelerated approval from the chairman of the Organic Chemistry Department in 1977, later FDA. Four additional drug development candidates support the was given the Foundation’s highest honor, being named “Senior company’s strategy of having “multiple shots on goal” – think of Scientist” and receiving from the Board of Trustees the Maltese a soccer team shooting at the goal five times instead of just once Cross, symbolic of intellectual acuity.
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