2016 ANNUAL REPORT Embracing theEmbracing Future Remembering the Past, the Past, Remembering TEXAS BIOMEDICAL RESEARCH INSTITUTE

TEXAS BIOMEDICAL RESEARCH INSTITUTE | 2016 ANNUAL REPORT 2016 ANNUAL REPORT

Remembering the Past, Embracing the Future The Board of Trustees Table of Contents

Executive Committee Dr. James (Jamo) Rubin, Chairman Mr. John R. (J.R.) Hurd 4 President’s Letter Chief Executive Officer, TAVHealth Chair, Hurd Enterprises, Ltd.

Mr. John E. Newman, Jr., Vice Chairman Mrs. Abigail G. Kampmann Principal, Newman Brothers Chief Executive Officer, Principle Auto 7 Pioneer of the Possible: Thomas Slick, Jr. Mr. James B. (Jamie) Smith Mr. John C. Kerr Secretary, Board of Trustees Principal, Moorman Kerr Interests Vice Chairman – Texas, Dykema Cox Smith 75 Years of Discovery Mrs. Marsha M. Shields 11 Dr. C. Collins (Andy) Anderson III President, McCombs Enterprises Dr. James (Jamo) Rubin Managing Partner, Windgate Partners, LLC Tenure began June 2016 12 A Timeline of Our History

Trustees Mrs. Emory Alexander Special Trustees Trustees Emeritus 16 75th Anniversary Celebration Hamilton Mr. Rex Amini Mr. Adam L. Hamilton Dr. Ronald K. Calgaard Partner, Groves Alexander Managing Director, President & CEO, Chairman, Ray Ellison Sage Energy Co. Mrs. Ashley Hixon Southwest Research Institute Grandchildren Trust 18 Champions of Discovery Hixon Family Office The Abbey Mr. Edward H. Austin, Jr. Dr. Andrea Giuffrida Principal, Mr. Richard Kardys Vice President for Research and Mr. Tom C. Frost Austin Family Investments Wealth Advisor Senior Officer, Professor, University of Texas Chairman Emeritus, Frost Bank 19 Circles of Giving Frost Bank Health Science Center at Mr. Richard N. Azar II San Antonio Mr. James W. Gorman, Jr. General Partner, Mr. William R. (Bill) Klesse Investor/Rancher Sezar Energy, L.P. The Forum Mrs. Carolyn H. Labatt Ex-Officio Trustee Mr. William E. Greehey 23 Mr. Craig Boyan Chief Executive Officer, Mr. Chris Petty Chairman, NuStar Energy, L.P. President & Chief Operating Computer Solutions President, Founder’s Council Mr. George C. (Tim) Hixon Officer, H-E-B 25 Founder’s Council Mr. Mark Pitman Mays Mr. John V. McLaughlin Investor/Rancher Mr. J. Bruce Bugg, Jr. Principal, Rocking M Capital President, The Argyle Chairman and CEO, Mr. B. D. Holt Argyle Investment Co., LLC Mr. Joe C. McKinney Mrs. Daniela Serna Chairman, Holt Companies 28 The Argyle Vice Chairman, President, Texas Biomedical Forum Mr. Milton B. Lee Mr. Robert M. (Bobby) Broadway National Bank Cavender (Retired) CEO, CPS Energy Mr. Lewis J. (Lew) Moorman IV Honorary Trustee President, Cavender Auto Group Mr. B. J. McCombs 30 Financials Entrepreneur Dr. John P. Howe III Ms. Phyllis Slick Cowell Chairman, McCombs Enterprises Dr. Dacia Napier Retired President/CEO, President, Slick Enterprises Mr. William G. (Bill) Moll Radiologist Project HOPE 32 New Grants and Contracts Mrs. Barbara B. Dreeben (Retired) CEO, KLRN Mr. Richard T. Schlosberg III (Retired) Chairman & CEO, Mr. Walter Embrey (Retired) Publisher and CEO, Clear Channel Television Chairman, Embrey Partners, Ltd. Los Angeles Times Administration, Faculty and Credits Mr. Lewis J. (Jeff) Moorman III 34 Mr. John W. Feik Mr. Charles (Chuck) Investor Chief Executive Officer, Urschel Slick Mr. Edward E. Whitacre, Jr. Feik Enterprises, LLC Partner, Slick Enterprises Chairman Emeritus, AT&T Mr. John B. Zachry Chairman and CEO, Zachry Group

2 3 A Letter from the President

Larry Schlesinger, M.D.

n 2016, Texas Biomed celebrated 75 years of with technology, and support a culture that optimizes discoveries that impact lives, and we will continue to make “Our greatest groundbreaking research and innovation. The Institute interdisciplinary research in all respects. strong investments in the environment and the development strength is our has a rich history of exploration and discovery, starting of our people for the sake of improving human health. Over I Because of its rich history and unique capabilities, Texas people – our staff, with its founder, Thomas B. Slick, Jr. Every day, the the next few years, we aim to add to our team of scientists people at Texas Biomed are turning his vision of a “great Biomed can compete effectively, even in a highly competitive, and encourage the development of junior researchers, so that our board and center for human progress” into reality, and I am excited underfunded environment. We have an opportunity as a we are also known as a place that not only shapes science but our supporters. to have joined the team. private, nonprofit research institute to gain a sustainable shapes scientists. We are united in competitive advantage provided that we have a clear vision our goal of making While I have just begun my tenure as President/CEO of and effective strategic plan. This will require change. Change takes time, but with the right people, a strong plan Texas Biomed, I see the strengths of the Institute as the and the support of the community, we can truly make today’s discoveries that We have biocontainment facilities unlike anywhere else in foundation for growth, and I see our challenges as discoveries possible of becoming tomorrow’s cures. impact lives, and the country tied to a National Primate Research Center. opportunities. These are exciting times in biomedical research With these unique resources as our cornerstone, we have we will continue with major breakthroughs in discoveries and technology the opportunity to create a master-planned institute with to make strong platforms. Having said this, scientific advances are a greater focus on discovery-based science leading to new investments in the progressing at a faster pace and this fact, combined with the diagnostics, therapies and vaccines! changing forces in funding biomedical research, necessitate environment and the development of our people that scientific institutes readily adapt to these changing forces, Our greatest strength is our people – our staff, our board Larry Schlesinger, M.D. for the sake of improving human health.” have infrastructure that is contemporary and well equipped and our supporters. We are united in our goal of making President and CEO

4 5 Pioneer of the Possible Thomas Baker Slick, Jr. 1916 – 1962

By Catherine Nixon Cooke

eventy-five years ago, when Thomas Baker Slick, Jr., established what is today the Texas Biomedical S Research Institute, he moved his favorite dream of Changing from the realms of his imagination into the real world. He envisioned San Antonio becoming a future “Science City” in the heart of Texas, and the new research institute was the first step. At just twenty-five years old, the World the Phi Beta Kappa graduate of Yale University already was committed to “giving back” to his community and Throughout our history, Texas beyond; and he believed that scientific research was the Biomedical Research Institute has most powerful way to make the world a better place. Born in Clarion, Pennsylvania on May 6, 1916, aimed to unravel the mysteries Tom Slick was the son of the largest independent oil of chronic and infectious diseases operator in the world. His father had discovered the huge Cushing Field in Oklahoma in 1912; and new through innovative thinking, oil exploration kept him traveling much of the time. His mother was the daughter of Joseph Frates, an creative problem solving and entrepreneur who had moved his family around the country many times; so she understood her husband’s cutting-edge technologies. absences and wanderlust. When the famous “King of the Wildcatters” was at home, he delighted in his three children, Tom, Betty, born in 1917, and Earl, born in “I don’t believe in failure… 1920, and instilled in them a spirit of adventure and curiosity, as they explored the Pennsylvania woods that only in outcome.” surrounded their house; and later looked for “ghosts” in the attic of a new home in Oklahoma City. – Tom Slick to a struggling inventor, 1952 Tragedy struck in 1930, when Slick, Sr., died of a stroke at only forty-six years old. His family inherited tremendous wealth, during a time that most of the

6 7 Leroy Denman “On the whole, I can’t say that and Tom Slick signing documents I have found life dull; and for what became Texas Biomedical I manage to keep interested Research Institute. in quite a lot of things.” – Tom Slick to a Yale classmate, 1956

Tom Slick (second from left), Dr. Nicholas Werthessen and Dr. Harold Vagtborg (right) discuss the future of the institution.

nation was feeling the austerity of the Great Depression. Along with that wealth came a strong sense of bred a “cross between a hog and a goat,” he sought out When Tom Slick was twenty-four years old, he bought a responsibility for others – something young Tom Slick the farmer, bought the “hoat,” and took it to his mother’s sixteen-hundred-acre tract of land on the outskirts of his felt from an early age. He attended Phillips Exeter farm in Oklahoma. Many years later, the adventure new hometown; and over the next year, he acquired more Academy in New Hampshire, where as captain of the became a favorite family story that Betty Slick Moorman land in the area, including the five-thousand-acre Cable debate team, he delighted in looking at problems from always told with a smile, adding that “luckily for all of Ranch. He named his new ranch ESSAR, an acronym of a variety of perspectives – fueling an open-mindedness us, Tom’s scientific interests began to find expression in sorts, reflecting his interest in science (“ESS” or “S”) and that would dominate his adult years. He found even other ways.” research (“AR” or “R”); and he was ready to move forward with his dream of creating a “Science City.” more excitement dabbling in the school’s state-of-the- In 1934, Tom Slick’s widowed mother married her art chemistry laboratory; and he carried his growing brother-in-law, Charles Urschel, whose wife had died a Just one week after Pearl Harbor was bombed by the interest in science to Yale University, where he pursued few years earlier. Young Tom, Betty and Earl gained a Japanese, Slick established the first of five research pre-medicine and was especially interested in the new sibling, Charles Urschel, Jr., who was also their first institutes that he would found before he was forty years possibilities of cross-breeding, which would later result cousin. The new expanded family blended happily, but old. He named it the Foundation of Applied Research, in a major contribution to the cattle industry. faced its first crisis when gangster “Machine Gun Kelly” and endowed it with an oilfield. The institute would As a college student, Tom was fascinated by more kidnapped the senior Urschel and held him for ransom. experience some name changes over the next seventy-five sensational possibilities. He traveled to Scotland with His rescue was dramatic and successful, ending with the years – becoming Southwest Foundation for Research fraternity brothers to investigate stories about the Loch capture and imprisonment of Kelly. After the ordeal, the and Education, then Southwest Foundation for Ness monster. And, after reading an article in Ripley’s Urschels left Oklahoma City and built a beautiful home in Biomedical Research, and finally, in 2011, Texas Believe It Or Not, about a farmer who claimed to have San Antonio, designed by renowned architect John Staub. Biomedical Research Institute.

8 9 Above: Tom Slick and Earl Slick

Tom Slick addresses board at annual meeting. His leadership and vision advanced the organization into the future. 75 Years of Discovery New Research Brings Hope Of Treatment

“Science gives us a tool of unparalleled effectiveness by rainforest, and the “Abominable Snowman” or “yeti” in which we can improve the physical side of our lives; and the Himalayas. In 1958, he founded his last scientific n December 8, 1941, President Franklin D. covering agricultural research, the natural sciences and since science recognizes no boundaries, the lives of people institute, the Mind Science Foundation, to study the Roosevelt declared December 7 as “a date which medicine. FAR’s name was changed in 1952 to the all over the world,” he told his family as he arranged mysteries of the human mind; it now focuses mainly on O will live in infamy.” The attack on Pearl Harbor Southwest Foundation for Research and Education, for some of his oil royalties to insure the new institute’s the neurosciences. had thrown the country into World War II and young succeeded by the Southwest Foundation for Biomedical financial future. men across America began preparing to leave their loved Research in 1984. In 2011, the name was changed to Tom Slick died in 1962, when his Beechcraft Bonanza ones and take up arms. Texas Biomedical Research Institute. Over the next few years, Tom Slick actively pursued 35 crashed over Montana in stormy weather. He left research opportunities for the new institute, and hired behind four children – William Lewis Slick, Patty Nixon Thomas Baker Slick, Jr. was only 25 years old, but like For 75 years, Texas Biomed has fulfilled Tom’s vision of its original six scientists, who would later describe their Slick (now Beem), Thomas Baker Slick, and Charles other young men at the time, he heeded the call of his embracing diverse scientific research at the highest level laboratories as “the Wild West,” without air conditioning, Urschel Slick, who is currently on the Board of the Texas country and volunteered for the U.S. Navy. Unlike other and has made life-saving breakthroughs. Scientific research and sometimes home to a stray rattlesnake. A man of Biomedical Research Institute. His legacy has grown to young men, Tom had a vision which he needed to execute. often begets disappointment and failure, but each learning, whether resulting in success or not, is a win. diverse interests, he also oversaw several ranches, helped include six grandchildren and seven great-grandchildren, “It has always been my intention to work towards the develop the Brangus breed of cattle and various new and encompasses seventy-five years of remarkable building of a great center for human progress through Even Tom knew this, writing to a disheartened scientist, species of grasses, established Slick Airways – the world’s contributions to science that have made this world a scientific research,” writes Tom in his last will and “I don’t believe in failure, only outcome. Where there is largest freight airline at the time – with his brother better place. Thank you, Tom Slick. testament. “I would like this effort to be as big as it soundly a disappointment of some sort, I never think it is the end Earl, and brother-in-law Lew Moorman, invented the can, and at the same time to embrace as wide a range of the story. I believe it’s the beginning of something new, Catherine Nixon Cooke is the author of three biographies: “Lift-Slab” method of construction, and drilled for oil of scientific research as is practical. Equally, if not more sometimes a great adventure.” Tom Slick Mystery Hunter, currently in development as a and found it. Expanding his “Science City” dream, he important than size and scope should be efforts to achieve major motion picture, The Thistle and the Rose: Romance, founded the Institute of Inventive Research, and in the highest quality of accomplishment.” 1947, Southwest Research Institute, now the third largest Railroads and Big Oil in Revolutionary Mexico, and Juan The following is just a sample of applied research institute in the world, located next door O’Gorman: A Confluence of Civilizations. She is currently On December 16, 1941, Tom established the Foundation Texas Biomed’s 75 year adventure… to Texas Biomed. He wrote two books about world writing the history of CPS Energy, and the untold story of of Applied Research (FAR). Endowed with 1,875 shares peace, mounted extraordinary expeditions in pursuit of the power company’s impact on San Antonio, scheduled for of the Slick-Urschel Oil Company, FAR’s mission was to mysteries, searching for “magical healers” in the Amazon publication by Trinity University Press in October. provide fundamental research and advanced education,

10 11 1940s 1950s • 1953, First grants awarded by the National Institutes of Health (NIH). • December 16, 1941, Tom Slick, Jr. formed the Foundation Our of Applied Research at age 25. He sought to create a research organization to meet the challenge of bettering mankind. The • 1951, Dr. Foundation, located on the famed “Essar Ranch” in San Antonio, Nicholas T. Texas, was formed with the mission to provide • 1947, Foundation Werthessen, History fundamental research and advanced education of Applied Research who studied in agricultural research, the natural opened its first cardiovascular sciences, and medicine. The laboratory building disease and • 1952, The Foundation A Timeline of ranch’s name “Essar” on the Cable Ranch • Harold Vagtborg, D.Sci. atherosclerosis, of Applied Research was chosen as a property. Initial (Hon), L.L.D. joined FAR. He initially used calves as (FAR) is renamed phonetic symbol of S research focused on FAR First President, an animal model until baboons were Southwest Foundation • 1956, First baboon colony for Research and Our Story and R, the first letters agriculture and 1948-1959 discovered to have fatty deposits in the established at SFRE from animals of scientific research. cattle breeding. aorta, similar to humans. Education (SFRE). acquired from the local zoo.

• 1963, Hixon • 1963, Dr. Seymour S. Kalter joined 1960s • 1958, NIH and Texas • 1956, Betty Slick Moorman, Tom Slick’s Animal SFRE to study microbiology and Heart Association sister and Foundation trustee, purchased and Research infectious diseases, and developed the • 1961, Surgeons provided funds to restored The Argyle as a private social club Laboratories baboon as a model to study viruses. worked on support the baboon to support the Foundation’s research. were completed. SFRE tripled in size techniques to colony to study the with the addition of the Ferdinand D. keep organs effects of heart disease Herff Memorial Research Laboratory, the alive outside with the baboon Chimpanzee Breeding Building and the the body before animal model. • 1958, First Primate Quarantine Building. transplantation. Construction of the expedition to Studies conducted baboon cages (aka Kenya to acquire • May 1967, The first shipment of included baboonery) began. animals. Six grown chimpanzees from the Congo arrived on • Harold Vagtborg – cardiovascular • Elbert DeCoursey, M.D. male baboons were campus. First assigned name was Harold. served as Administrative disease, ovarian SFRE President, shipped to SFRE function, and lipid Director, 1961-1970 • 1962, Tom Slick Jr. died in a plane crash 1959-1961 from Africa. metabolism in in Dillon, Montana at the age of 46. the brain.

• 1971, SFRE • 1978, The National Cancer • 1979, the tether system 1970s developed totally Institute supported the allowed arterial pressure and • 1970, The Southwest Foundation Forum germ-free infant chimpanzee colony for critical heart rate to be measured in was chartered as a women’s group to promote baboons by cancer studies. In 1979, awake baboons. Dr. Dee the work of the Foundation in the community isolating them the NIH National Heart, Lung Carey, Terry Hawkins, through education and fundraising programs. from the outside world. These special and Blood Institute awarded and Dr. Robert Shade In 1977, the Golden Circle was created baboons were used to study various SFRE a contract to maintain continued to refine it. to increase the cancers, specifically leukemia. an NIH chimpanzee philanthropic support colony for hepatitis of the Foundation • 1971, The Foundation research. by individuals and library was rededicated businesses. The as the Preston G. symbol represents the Northrup Memorial • Stanley W. Olson, M.D. • Martin A. Goland unending search for Library, in honor of SFRE President, SFRE President, truth and knowledge, Mr. Northrup’s contributions • 1973, Dr. Henry C. McGill Jr., M.D., 1970-1972 1973-1982 the essence of scientific to the library since joined SFRE and became the first research. its inception. Scientific Director in 1979.

12 13 1980s • 1983, Dr. Jorg Eichberg and Dr. S.S. 1990s • 1990, Genetically • 1991, SOLAR, a genetic Kalter began studying the AIDS virus using engineered AIDS vaccine analysis software package • 1981, SFRE was the world’s only primate center with baboons and chimpanzees as a nonhuman protected two chimpanzees developed by SFBR scientists cardiac catherization and angiography equipment. The primate model. at the Foundation from and now used by more than 5,000 special x-ray machine enabled scientists to examine the infection. researchers worldwide, was released. heart and its arteries. • 1984, Dr. Jean MacCluer and Dr. Bennett Dyke developed computerized • 1991, The Mexican • 1996, Dr. Jean Patterson • 1981, The Southwest Foundation Forum funded statistical methods for analyzing populations • 1984, Southwest Foundation American Program Project joined SFBR as the chair of researchers to develop a model to study infant respiratory genetic data. distress syndrome. Researchers studied the use of the high for Research and Education was funded by NIH to support the the Virology and Immunology frequency ventilator to provide premature renamed Southwest Foundation San Antonio Family Heart department. She was baboons with lower airway pressure. for Biomedical Research. study. Dr. Jean MacCluer instrumental in opening and led a team of 20 researchers designing the maximum • 1983, The world’s first nonhuman • 1986, “Florentina”, a 10-week • Duncan G. Wimpress, Ph.D. to identify specific genes biocontainment laboratory to primate was born on July 25 from an premature chimpanzee became the SFRE President, that influence susceptibility study threats in bioterrorism. in vitro fertilized embryo and was named first chimpanzee placed on a high 1982-1992 to coronary heart disease in She began the first studies using select agents “E.T.” (Embryo Transfer). frequency ventilator. Mexican Americans. including anthrax and tularensis.

• 2007, Drs. Harald Göring, Shelley Cole, 2000s David Rainwater, Anthony Comuzzie, Jean MacCluer, • 2003, The AT&T Genomics Computing • 2000, The Biosafety et al. discovered the VNN1 gene that plays Center opened with 3,000 processors, Level 4 Lab became • 1997, The Department a major role in the regulation of HDL improving the ability of scientists to fully operational. of Genetics began to (good) cholesterol levels and may play a identify genes influencing common diseases. SFBR is the only identify genes influencing • 1997, The Foundation broke ground on the part in heart disease prevention. institution in the food intake and body fat 34,000 sq. ft. Betty Slick and Lewis J. • 2008, The Department of Organic • 2004, Dr. Robert Lanford and country to house both endocrine function. Research Moorman, Jr. Laboratory complex. Chemistry becomes Evestra, a private Dr. Krishna Murthy continued their a BSL-4 lab and on these genes helped work to develop a Hepatitis C virus vaccine a national primate pharmaceutical company to produce new • 1999, The NIH National Center for Research aid in the identification using chimpanzees. research center. contraceptives and treatments for breast Resources announced the establishment of the of individuals at risk of Dr. Lanford discovered • Anthony J. Infante, M.D., • John C. Kerr, J.D. and prostate cancer. • Frank F. Ledford, Jr., M.D. eighth Regional Primate Research Center developing obesity and, the first evidence that Ph.D. SFBR President, SFBR President, • 2009, Dr. Laura Cox, et al. identified SFBR President, (SNPRC) in the country at SFBR. potentially, in the a variant in a gene that regulates levels a vaccine against all 2005-2006 2006-2008 1992-2005 development of treatments of “good” cholesterol using the SNPRC’s strains of the virus to prevent obesity and Southwest National Primate pedigreed baboon colony. could be possible. Research Center related conditions.

• 2010, Dr. Andrew • 2012, Dr. Tim Anderson • 2013, In separate Hayhurst studies the use and Dr. Ian Cheeseman were studies, scientists 2010 of llama antibodies to involved in two studies identifying Dr. Robert Davey, quickly detect microbes and a major region of the malaria Dr. Jean Patterson and to toxins that could be used in parasite genome associated with Dr. Ricardo Carrion, today bioterrorism attacks. In 2014, artemisinin resistance. Jr. reported findings of his lab identified antibodies two drugs that protected • 2012, Dr. Robert Lanford and his team tested a • 2014, The Earl Slick Building, named in that recognized a small mice against anthrax, human monoclonal antibody targeting the Hepatitis honor of Tom Slick’s brother for his role in the conserved region of protein while another drug used C virus and found that it protected chimpanzees institute’s development, opened with 70,000 sq. in Marburg virus with to treat malaria protected from HCV infection in a dose-dependent manner. ft. of laboratory and office space. a very similar architecture Dr. Lanford has been involved in the testing of mice against Ebola. • 2015, Dr. Robert Davey publishes findings to Ebola virus. new antiviral therapies for the in the journal “Science” on a small molecule • 2011, Southwest Foundation treatment of chronic hepatitis inhibiting Ebola virus infection in vitro. for Biomedical Research was infections. Today, two antiviral • Kenneth P. Trevett, J.D. • Robert W. Gracy Ph.D. • Dr. Larry S. Schlesinger renamed Texas Biomedical cocktails are FDA approved and • 2016, NIH awards Texas Biomed $23 million SFBR/Texas Biomed President, Texas Biomed President, Texas Biomed President, Research Institute others are near approval that can cure HCV with program project to work on AIDS vaccine 2008-2014 2014-2017 2017 (Texas Biomed). 12 weeks of daily oral medications. development led by Dr. Ruth Ruprecht.

14 15 A COMMON BOND A SHARED VISION

Honoring Donors and Members “Every person here shares the honor of what we have together of the Texas Biomedical created – this shared vision and shared purpose – the vision of Research Institute and The Argyle creating a GREAT CENTER FOR HUMAN PROGRESS.” On a beautiful November evening in 2016, more than – Dr. James (Jamo) Rubin 500 donors gathered to celebrate two anniversaries.

17 Texas Biomed Contributions Mr. and Mrs. Jack E. Guenther, Jr. Robert A. & Kathey K. Anderson Foundation Circles Mr. and Mrs. Curtis C. Gunn, Jr. Robert J. Jr. and Helen C. Kleberg Mr. and Mrs. Frederic Hamilton Foundation H-E-B Rod & Kim Lewis Foundation Champions of Discovery of Giving Mr. and Mrs. John L. Hendry III Roger L. & Laura D. Zeller Charitable Foundation Henry J. Kaiser Family Foundation Rose A. Sinkin Trust Mr. and Mrs. H. Wayne Hightower very day, our team at Texas Biomed looks for solutions to health threats Ruth Chapman Cowles & Mr. and Mrs. George C. Hixon that exist today and dangers we have yet to see. Each and every one of CHAIRMAN’S Andrew G. Cowles Memoriam Holt Foundation our colleagues labors in the present with a hopeful eye on the future. Mr. Barclay C. Adams RWM Foundation E Mr. B. D. Holt Our work is not possible without people who understand that a commitment The Honorable and Mrs. Clyde H. Alexander San Antonio Area Foundation Mr. and Mrs. John R. Hurd to scientific research happening right now will produce rewards for generations Mr. and Mrs. Rex Mitchell Amini Mr. and Dr. Richard T. Schlosberg III Jack and Valerie Guenther Foundation to come. Albert Camus wrote, “Real generosity toward the future lies in giving Dr. and Mrs. C. Collins Anderson Semmes Foundation, Inc. Jack Bennett Testamentary Trust all to the present.” Mr. and Mrs. Robert A. Anderson Mr. and Mrs. Thomas R. Semmes Mr. Dunham F. Jewett AT&T Sheila Silverman Charitable Remainder

Our team gives its all every day to unlock the mysteries of chronic and Mr. and Mrs. James Avery Joe & Jessie Crump Foundation Annuity for Medical Research infectious diseases. Each of you is part of this effort through your support Mr. and Mrs. Richard N. Azar II The Honorable and Mrs. John Shields John and Florence Newman Foundation and dedication to our mission. Investing in biomedical research now is truly Mr. and Mrs. Sam P. Bell, Jr. Mr. and Mrs. Charles Urschel Slick Mr. and Mrs. William A. Johnson a generous gift to the future. Mr. and Mrs. David Berndt Mr. Banks M. Smith JP Morgan Chase Betty Stieren Kelso Foundation Mr. and Mrs. Forrester M. Smith III Texas Biomed was founded 75 years ago on the foresight and philanthropic Judith N. Morton Irrevocable Dr. and Mrs. Lon S. Smith support of people who wanted to be a part of building a brighter, healthier Bill and Melinda Gates Foundation Life Insurance Trust Stumberg Foundation future, and that legacy remains strong. Donations fund the hope necessary Mr. and Mrs. Craig Boyan K.S. Adams, Jr. Foundation Brown Foundation, Inc. Texas Biomedical Forum to keep searching for answers to our world’s most vexing health threats. Mr. and Mrs. George A. Kampmann, Jr. Mr. Charles C. Butt Mr. and Mrs. Richard Kardys Tim and Karen Hixon Foundation And, every donor to Texas Biomed – like our founder, Tom Slick – envisions Capital Group Companies Mr. and Mrs. Robert E. Kelso TOPS Club, Inc. a healthier future and aims to enhance lives through discovery. Charitable Foundation (In Memoriam) True Firm Foundation Cappy’s Inc. & La Fonda, Inc. Mr. and Mrs. John C. Kerr Mr. and Mrs. Curtis T. Vaughan III Mr. and Mrs. Charles E. Cheever, Jr. Klesse Foundation V. H. McNutt Memorial Foundation It is an honor to acknowledge the exceptional support of the following donors, whose significant financial contributions Ms. Phyllis Slick Cowell Mr. and Mrs. William R. Klesse Virginia C. Joslin Trust to Texas Biomed enabled our scientists to tackle truly life-changing research: Dr. Laura Cox and Mr. Jim Griffin Mr. and Mrs. Robert C. Kusenberger Mr. and Mrs. Edward C. Welsh Dickson-Allen Foundation Mr. Barclay C. Adams G. Harold and Leila Y. Mathers Klesse Foundation La Brasada Foundation Mr. and Mrs. Chris Wilde Mr. and Mrs. James L. Donnell Mr. and Mrs. Rex Mitchell Amini Charitable Foundation Mr. and Mrs. Rodney Ray Lewis Lanward Foundation, Inc. Mr. and Mrs. Stephen B. Wilde Mr. and Mrs. James L. Donnell, Jr. Dr. and Mrs. C. Collins Anderson G.A.C. Halff Foundation Ms. Mary Sue Marmion Mr. and Mrs. Cappy Lawton Mr. and Mrs. Warren S. Wilkinson, Jr. Douglass Foundation Mr. and Mrs. Steven Q. Lee William and Ella Owens AT&T Goldstein Family 2007 Trust Max & Minnie Tomerlin Voelcker Fund Mr. Donald J. Douglass (In Memoriam) Mr. and Mrs. Rodney Ray Lewis Medical Research Foundation Mr. and Mrs. Richard N. Azar II Gorman Foundation Mr. and Mrs. L. Lowry Mays Mr. and Mrs. Alan W. Dreeben Ms. Mary Sue Marmion Mr. and Mrs. James C. Worth Mr. and Mrs. Sam P. Bell, Jr. Mr. and Mrs. James W. Gorman, Jr. Mr. and Mrs. Mark P. Mays Mrs. Helen Kleberg Groves eBay, Inc. Marvin Silverman Charitable Mr. and Mrs. Robert L. Worth, Jr. Betty Stieren Kelso Foundation Mays Family Foundation Remainder Annuity Mr. and Mrs. James P. Zachry Mr. and Mrs. Frederic Hamilton Elise Silverman Charitable Remainder Bill and Melinda Gates Foundation McCombs Foundation Annuity Max & Minnie Tomerlin Voelcker Fund H-E-B PRESIDENT’S Brown Foundation, Inc. Mr. and Mrs. John E. Newman, Jr. Elizabeth Huth Coates Charitable Foundation Mays Family Foundation Mr. and Mrs. George C. Hixon Mr. Charles C. Butt Perry & Ruby Stevens Charitable Foundation Mr. Donald G. Elliott Mr. and Mrs. L. Lowry Mays 2011 Eric Hill Gift Trust Holt Foundation Mr. and Mrs. Charles E. Cheever, Jr. Phoenix Charitable Foundation Ellwood Foundation Mr. and Mrs. Mark P. Mays Amy Shelton McNutt Charitable Trust Mr. B. D. Holt Ms. Phyllis Slick Cowell Robert J. Jr. and Helen C. Kleberg Foundation Mr. and Mrs. Walter Embrey, Jr. McCombs Foundation Mrs. Robert R. Archer Jack Bennett Testamentary Trust Dickson-Allen Foundation Roger L. & Laura D. Zeller Estate of Betty Jane Belstrom Wray Mr. and Mrs. B. J. McCombs Mr. and Mrs. John C. Asel Douglass Foundation Joe & Jessie Crump Foundation Charitable Foundation Fletcher Jones Foundation Dr. Basil E. Atkinson, Jr. (In Memoriam) for Medical Research McCrea Foundation Mr. Donald J. Douglass (In Memoriam) Ruth Chapman Cowles & Founder’s Council Mr. and Mrs. Lewis J. Moorman IV Mr. and Mrs. Edward H. Austin, Jr. John and Florence Newman Foundation Andrew G. Cowles Memoriam Mr. and Mrs. Alan W. Dreeben Mr. and Mrs. Larry Franklin Mr. (In Memoriam) and Broadway Bank JP Morgan Chase San Antonio Area Foundation Elise Silverman Charitable Remainder Annuity Franklin Family Foundation Mrs. Lewis J. Moorman III Mr. and Mrs. A. H. Cadwallader IV Judith N. Morton Irrevocable Texas Biomedical Forum Mrs. Judith N. Morton Dr. and Mrs. Ronald K. Calgaard Elizabeth Huth Coates Charitable Foundation Life Insurance Trust Frost Tim and Karen Hixon Foundation Ms. Patricia P. Muir Mr. and Mrs. Robert M. Cavender Mr. Donald G. Elliott Judith N. Morton Mr. and Mrs. Tom C. Frost, Jr. TOPS Club, Inc. Myra Eilenberg Charitable Annuity Trust Mr. and Mrs. Justin Cole Estate of Betty Jane Belstrom Wray K.S. Adams, Jr. Foundation G.A.C. Halff Foundation V. H. McNutt Memorial Foundation Dr. Peter W. Nathanielsz Dawson Family Foundation Fletcher Jones Foundation Mr. and Mrs. Richard Kardys G. Harold and Leila Y. Mathers William and Ella Owens Medical Charitable Foundation Mr. and Mrs. John E. Newman, Jr. Mr. and Mrs. Berkley Dawson Founder’s Council Mr. and Mrs. (In Memoriam) Robert E. Kelso Research Foundation Goldstein Family 2007 Trust NuStar Energy Mr. and Mrs. Trey Dawson Frost Mr. and Mrs. William R. Klesse Gorman Foundation Mr. and Mrs. Thomas I. O’Connor III Mr. and Mrs. A. R. Dooley, Jr. Mr. and Mrs. James W. Gorman, Jr. Perry & Ruby Stevens Charitable Foundation Edouard Foundation, Inc. For more information about giving opportunities, please contact Mrs. Helen Kleberg Groves Phoenix Charitable Foundation Mr. and Mrs. James D. Ellis Texas Biomed Vice President for Institutional Advancement Corbett Christie at 210-258-9870 or Mr. and Mrs. Jack Guenther R.L. Worth Family, L.P. Mr. H. Rugeley Ferguson (In Memoriam) [email protected], or visit our web site at www.TxBiomed.org and click on “Support Us.” CONTINUED ON PAGE 20

18 19 Weston Centre Tim & Suzanne Word Foundation Mr. and Mrs. J. Bruce Bugg, Jr. Mr. and Mrs. John W. Feik, Jr. Ms. Sara Smith Hurd Circles of Giving Ms. Jean Cheever Tobin Endowment Mrs. George V. Burkholder Fidelity Brokerage Services, LLC Mr. and Mrs. Michael G. Imber CONTINUED FROM PAGE 19 Mr. and Mrs. Corbett Christie Mr. Dale W. and Dr. Sandra Tremblay Mr. and Mrs. Walter J. Buzzini III Mr. Robert H. and Dr. Nancy A. Finney J.P. and Mary Jon Bryan Foundation Dr. Robert R. Clemons Ms. Susanne W. Vanham C. F. Jircik Mr. and Mrs. Eric Fisher Mr. and Mrs. Anthony C. Johnson Mr. and Mrs. Ron Finch Daniel J. Sullivan Family Mr. and Mrs. Ben F. Vaughan IV Mr. and Mrs. Wade Caldwell Mr. and Mrs. Hugh Fitzsimons, Jr. Johnson Investment Counsel Mr. and Mrs. James D. Goudge Charitable Foundation William and Salome Scanlan Foundation Mr. and Mrs. Richard W. Calvert Mr. and Mrs. W.W. Flannery, Jr. Mr. and Mrs. J. Bradley Jones Mrs. Marie Halff Mr. Thomas H. Edson Mr. and Mrs. James M. Wolff Mr. and Mrs. Don Cangelosi Mr. and Mrs. Edward C. Flato Mrs. Joe Warren Jones Harris K. & Lois G. Oppenheimer Mr. and Mrs. Jeff Edwards Mrs. Suzanne Word Ms. Jo Canter (In Memoriam) Flohr Family Foundation Julian Gold, Inc. Foundation Mr. and Mrs. John W. Feik Mr. Mike Yantis Mr. and Mrs. John Cantrell Flora Cameron Foundation Mrs. George A. Kampmann Mr. and Mrs. Warren B. Hart II Mrs. Charles E. Foster Yantis Company Dean Charles E. Cantu Mrs. Caroline A. Forgason Mr. and Mrs. William M. Kanyusik Mr. and Mrs. Joe N. Haynes Mr. and Mrs. William A. Freed Mr. and Mrs. Keith Zars Dr. and Mrs. Carlos Cardenas Mr. Charles A. Forster Mr. and Mrs. Creston A. King III Herrmann Family Charitable Foundation Mr. and Mrs. Stephen Goebel Mr. and Mrs. Claiborne Ayres Carrington Foundation for Jewish Philanthropies Mr. and Mrs. Robert A. Kiolbassa Mr. and Mrs. Roger C. Hill, Jr. GOLDEN of San Antonio Gunn Family Foundation Mr. and Mrs. William Carrington Kittie Nelson Ferguson Foundation Hixon Properties, Inc. Mr. and Mrs. Brett Alvheim Mr. and Mrs. Aubra L. Franklin Mr. and Mrs. Harry Halff Mr. and Mrs. Richard H. Cavender Mr. and Mrs. Richard M. Kleberg III Mr. Thomas Francis Hogan III Argonaut Group, Inc. Mr. and Mrs. Casey Fry Mr. and Mrs. Adam L. Hamilton Mrs. James M. Cavender III Mr. and Mrs. Edward K. Kopplow Mr. and Mrs. John R. Hurd, Jr. Argyle Foundation Mr. and Mrs. Thomas A. Gates Mr. and Mrs. Michael Harper Cavender Auto Group Mr. and Mrs. John C. Korbell J & M Rubin Foundation Mr. and Mrs. Brian Arriaga Mr. and Mrs. George A. Geis Mr. and Mrs. Robert T. Hayes Cavender Brothers Management, Ltd. Mr. and Mrs. Gregory W. Kowalski Mr. and Mrs. Mark M. Johnson Mr. Aaron Asel Mr. Lukin T. Gilliland, Jr. Mr. and Mrs. Timo Hixon Cavender Toyota Mr. and Mrs. William Travis Kowalski Mr. Walter Juliff Avalon Advisors, LLC Mr. and Mrs. James L. Glover Mr. and Mrs. Mark S. Howard Mr. Charles E. Cheever III Ms. Rosemary Kowalski Mr. and Mrs. John Knock Dr. and Mrs. Wilbur S. Avant, Jr. Mr. and Mrs. Christopher Goldsbury, Jr. Jackson Walker, LLP Mr. Chris Cheever Mr. and Mrs. Michael L. Kreager KT Family Holdings Mr. and Mrs. Edward Badouh III Dr. and Mrs. Joseph W. Goldzieher Joseph & Madelon Harrison Mr. and Mrs. Malcolm G. Chesney Dr. and Mrs. Ariel Kruger Mr. and Mrs. Mark Lewis Family Advised Fund Mr. and Mrs. Jeff P. Bailey Mr. and Mrs. Joseph W. Gorder Mrs. M. A. Childers Mr. and Mrs. William Jeffrey Kuhn Mr. and Mrs. Taylor Little Mr. and Mrs. William Scanlan, Jr. Mr. and Mrs. Joseph Stewart Bakke Dr. and Mrs. William W. Gordon Mrs. Malcolm H. Cohen Mr. and Mrs. Joseph B. Labatt Mr. and Mrs. Richard F. Lord Mr. and Mrs. Bob Kolitz Mr. and Mrs. Phil Bakke Mr. and Mrs. James B. Gouger Mr. and Mrs. Norborne P. Cole, Jr. Mr. and Mrs. Pete LaBonte Lorene March Partnership Kolitz Foundation, Inc. Mr. and Mrs. Brian Ballantyne Mr. and Mrs. John Paul Gould Columbia Realty, Ltd. Mr. and Mrs. Bill N. Lacy Mr. and Mrs. Clark R. Mandigo II Mr. and Mrs. Stephen P. Ballantyne Government Personnel Mutual Mr. Trevor Lawton and Ms. Amy Stinson Dr. and Mrs. Robert Lanford Mr. and Mrs. Don B. McDonald, Jr. Mr. and Mrs. John Barnes IV Mr. and Mrs. Craig Comeaux Life Insurance Co. Mr. and Mrs. Richard F. Lord Law Office of S. Mark Murray, PLLC Mr. and Mrs. Matthew Z. Mosser Mr. and Mrs. James Hunter Barrow Commercial Storage Specialists Dr. and Mrs. Robert Gracy Lt. General and Mrs. Frank F. Ledford, Jr. Lee Michaels Fine Jewelry Ms. Lynn Tidwell Neff Mr. Bruce B. Barshop Concord Oil Company Greater Houston Community Foundation Mr. and Mrs. James R. Marmion III Mr. and Mrs. Milton B. Lee Nordan Trust Mr. and Mrs. Lee M. Bass Mrs. George J. Condos Mr. and Mrs. Phillip D. Green Ms. Janey Marmion Mr. and Mrs. Byron L. LeFlore, Jr. Mr. Charles G. Northrup Mr. and Mrs. Jim Baxter Mr. and Mrs. John B. Connally III Mr. and Mrs. Claiborne B. Gregory, Jr. Ms. Ann Marmion Mr. and Mrs. Ralph Lehr, Jr. Mr. and Mrs. Andrew J. Novak BB&T Mrs. John Crichton Dr. and Mrs. Kennon Guglielmo Mr. and Mrs. James H. Martin, Jr. Mrs. John R. Less Mr. and Mrs. Alex H. Oliver Ms. Jean Beasley (In Memoriam) Mr. and Mrs. Joshua Crumpton Guido Brothers Construction Matera Paper Company Mr. and Mrs. A.J. Lewis III Mrs. Claire Oppenheimer O’Malley Mr. and Mrs. J. Scott Beckendorf Mr. and Mrs. Michael Cruz Mr. and Mrs. Thomas L. Guido Mr. and Mrs. Robert S. McClane Mr. and Mrs. Steve C. Lewis Mr. and Mrs. Allan G. Paterson Mr. and Mrs. Brian Beem Mr. and Mrs. Paul T. Curl Mr. Cosmo F. Guido Mr. and Mrs. Sean McNelis Mr. and Mrs. A. Jack Lewis, Jr. Ronald & Gene Calgaard Charitable Fund Mrs. Marion Dewar Bell Mr. and Mrs. Peter B. Dahlberg Mr. and Mrs. Robert Gurwitz McNelis + Associates, PLLC Mr. and Mrs. Walter Scott Light Dr. and Mrs. James M. O. Rubin Mr. and Mrs. Matthew M. Bell David and Letty Lew Lloyd Mr. and Mrs. Mark Hanrahan Minnie Stevens Piper Foundation Family Charity Fund Ms. Joyce Lindler Rugeley Ferguson Foundation Mr. and Mrs. Michael L. Benedum Mr. and Mrs. Daniel Hargrove Mr. and Mrs. William G. Moll Mr. Keith A. Davis Lindsay Production & Royalties, Ltd. Ruth and Edward Austin Foundation Mr. and Mrs. Barry G. Benton Mr. and Mrs. William E. Harrison, Jr. Mr. S. Mark Murray Mrs. Bond Davis Dr. and Mrs. David G. Lloyd Sara Stumberg Walker Fund Mr. and Mrs. Ryan Berg (In Memoriam) Mr. and Mrs. Edward Hart Mr. Lanham and Dr. Dacia Napier Ms. MaryEllen Londrie Mr. and Mrs. Tobin Scroggins Mr. Jeffrey H. Berler Mr. and Mrs. Jeffrey de Rojas Ms. Mary Austin Hart Nelson Puett Foundation Mr. and Mrs. Porter Loring III Mr. and Mrs. Jack J. Spector Mr. and Mrs. Mark J. Berridge Mrs. Leroy G. Denman, Jr. Mr. and Mrs. Houston Harte Pape-Dawson Engineers, Inc. Mr. and Mrs. Howard H. Lutz Mrs. Louis Stumberg Mrs. Lawrence A. Bertetti Mr. and Mrs. Christopher H. Dewar Harte Management Trust Mr. and Mrs. Andrew B. Price Mr. and Mrs. Douglas G. Macdonald USAA Foundation, Inc. Mr. and Mrs. Albert M. Biedenharn III Mr. and Mrs. Michael Dewar Mr. and Mrs. James L. Hayne Principle Auto Group Mr. and Mrs. Mike MacNaughton Mr. and Mrs. W. Lawrence Walker III Bill Miller Bar-B-Q Enterprises, Ltd. Mr. and Mrs. Robert L. Dewar Mrs. Frances J. Hearn Project Control of Texas, Inc. Mr. and Mrs. Glenn MacTaggart Ms. Ann Brennand Watson Ms. Margery L. Block Mr. and Mrs. James F. Dicke II Mr. and Mrs. Jeffrey E. Heinke Mr. and Mrs. Nelson H. Puett Mr. and Mrs. John M. Mallory Wave Healthcare, LLC Mr. and Mrs. John Paul Boldrick Mr. and Mrs. Blackstone Dilworth Mr. and Mrs. Roger Hemminghaus Dr. Carl F. Raba, Jr. Mr. and Mrs. Gregory Mann Wells Fargo Advisors, LLC Mr. and Mrs. Robert L. Bowers DOCUMation, Inc. Mr. and Mrs. Peter J. Hennessey III Rachael & Ben Vaughan Foundation Mr. and Mrs. Rob Marshall Mr. and Mrs. Robert Clinton Worth Mr. and Mrs. McLean Bowman Mr. and Mrs. Kenneth Dorbandt Mr. and Mrs. David S. Herrmann Mr. and Mrs. Houston Reagan IV Mr. and Mrs. Charles G. Martens Mr. and Mrs. John B. Zachry Dr. and Mrs. Warren B. Branch Mr. and Mrs. William E. Dreyer Mr. and Mrs. Ronald J. Herrmann Mr. and Mrs. B. Coleman Renick, Jr. Dr. Kathleen Brasky DuWest Realty Mr. Jonathan Hess Mr. Paul Martin BENEFACTOR Mr. and Mrs. John Richardson Brigadier General Julius H. Braun Dykema Cox Smith Ms. Henrietta P.C. Hildebrand Martin Capital Advisors, LLP Bank of America Matching Gifts Robert Tucker Hayes Foundation (In Memoriam) Mr. and Mrs. Michael Ellis Mr. and Mrs. Charles R. Hollimon Matthias Schubnell and Erika Ivanyi Bank of America RSM US LLP Dr. Sara McCamish and Dr. Edward Briggs Eugenia and Lawrence A. Bertetti Foundation Dr. Peter W. Hollimon and Mauze Construction Bank of San Antonio Mr. and Mrs. Norton A. Stuart III Mr. and Mrs. James C. Browning Mr. (In Memoriam) and Mrs. Dr. Mary H. Arno Mr. and Mrs. David Mauze Mr. and Mrs. Bruce Blakemore Mrs. Daniel J. Sullivan IV Mr. J. Craig Browning, Jr. Richard W. Evans, Jr. Mr. and Mrs. Charles M. Hornberger Mr. and Mrs. Madison Mauze Mrs. Walter F. Brown Texas Capital Bank Mr. and Mrs. John Brozovich Mr. and Mrs. Robert E. Fawcett, Jr. Hornberger Fuller & Garza, Inc. Mr. and Mrs. Jess Mayfield Brown & Ortiz, P.C. Mr. and Mrs. John C. Thomas Mr. John B. Bryan Mrs. Carolyn Grant Fay Mr. and Mrs. Dan Allen Hughes, Jr. Mr. W.W. ‘Bo’ McAllister III

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20 21 Mr. and Mrs. Scott Petty, Jr. Mr. and Mrs. George L. Stieren Circles of Giving Mr. and Mrs. John A. Peveto, Jr. Mr. and Mrs. Russell Stith CONTINUED FROM PAGE 21 Mr. and Mrs. Philip J. Pfeiffer Mr. and Mrs. Thomas D. Stribling 2016 Texas Biomedical Forum Mr. and Mrs. Alistair F. Philip Mr. and Mrs. John P. Summers Mr. and Mrs. Norris Robert McClane Mr. and Mrs. Karl W. Poorbaugh Ms. Shelley M. Summers Ms. K. Heather McFarlin Mr. Vincent and Dr. Cyndi Porter Susan Shaw Collection, Ltd. Mr. and Mrs. Elkin McGaughy Dr. and Mrs. William C. Powell Mr. and Mrs. Timothy L. Swan McGaughy Construction Co. Mrs. Thomas L. Powell, Jr. Mr. and Mrs. Stephen Lee Swanson he purpose of the Texas Biomedical Forum, known simply as the ‘Forum,’ is Dr. Henry C. McGill (In Memoriam) Mr. and Mrs. William H. Quirk IV Mr. Patrick H. Swearingen, Jr. Mr. and Mrs. Anne O. McNeel R.L. Worth & Family, L. P. Mr. and Mrs. Ty Thaggard to support Texas Biomed through community relations, volunteer services and Mr. and Mrs. Paul E. McSween, Jr. Mr. and Mrs. James L. Ramsey Dr. and Mrs. Alvin Thaggard III T fundraising. Formed in 1970-71, Dottie Dreeben Block served as the organization’s Mr. and Mrs. Charles McTee Mr. and Mrs. R. Lane Riggs Mr. Richard Thompson first President. The Forum is its own non-profit organization comprised of women ages 21 Mrs. Jo Lynne Meador Dr. and Mrs. Mark C. Rittenhouse Mr. Ron Thompson years and older. Our three mission components are achieved in the following ways… Dr. and Mrs. Gilbert R. Meadows Dr. and Mrs. Isaac R. Rodriguez-Chavez Thompson Landscape Company Community relations of the Forum involve hosting two lecture luncheons annually, one Mr. and Mrs. Richard Menchaca Mr. and Mrs. Paul Rohlfs Dr. and Mrs. Brad S. Tolin roundtable discussion, several special events a year, monthly student tours for high school Mr. and Mrs. Mort Mertz Rotary Club of San Antonio Mr. and Mrs. Richard C. Traylor students, annual science education awards for high school teachers, as well as publishing Mr. and Mrs. John K. Meyer Mrs. Harold Rother Mr. James M. Truss our Forum in Focus newsletter three times per year. Volunteer services are accomplished Michael G. Imber, Architect, PLLC Mrs. Jay Lewis Rubin Mr. and Mrs. Robert E. Tucker, Jr. primarily by our Board Trustees, Advisors and Honorary Advisors. Fundraising Mr. Fred W. Middleton Mr. and Mrs. McLean Douglas Russell Mr. and Mrs. Arthur Uhl III is a Forum specialty. Membership dues fund most of our Forum work, including Mr. and Mrs. Balous T. Miller Mrs. Ruth Bowman Russell Dr. and Mrs. George J. Vassar Texas Biomed is a Mr. and Mrs. Joe Miller RVK Architects Mr. and Mrs. Michael N. Venson administrative needs and, importantly, our science education awards program. The Forum Dr. and Mrs. Joseph P. Miller Dr. and Mrs. Frank C. Sammis III Mr. and Mrs. Jack Vexler true treasure in our Gala specifically fundraises for pilot study grants done by Texas Biomed research scientists Mission Pharmacal Mr. William and Dr. Nancy Saunders Drs. Sergio and Alice Viroslav community, and The to accomplish investigational, small scale studies, which can lead to competitive, well- Mission Title Mr. and Ms. William I. Saunders Mr. and Mrs. Keith Vogel funded grants by national agencies. Mr. and Mrs. Stuart D. Moiles Mr. and Mrs. J. Thomas Schmidt Mr. and Mrs. Richard Wade Forum takes time to We had a truly amazing 2016-17 Forum year! We had the pleasure of welcoming the Mr. and Mrs. Michael L. Molak Mrs. Robert L. Schupbach Mr. and Mrs. W. Lawrence Walker, Jr. educate our community following Texas Biomed scientists to our Roundtable Discussions in October 2016: Monterrey Iron Mr. and Mrs. Harry F. Schwethelm, Jr. Mr. Neill Walsdorf, Jr. Dr. Manu Anantpadma, Dr. Christopher Chen, Dr. Shelley Cole, Dr. Marcel Daadi, Mr. and Mrs. Edward D. Moore Mrs. H. Kyle Seale Mr. and Mrs. Thomas R. Ward about the importance Dr. Luis Giavedoni, Dr. Andrew Hayhurst, Dr. Michael Olivier, Dr. Michael Proffitt, Mr. and Mrs. John Moorman Mr. and Mrs. Donnie Seay Mr. and Mrs. Mark E. Watson III Dr. Kimberly Reeves and Dr. Ruth Ruprecht. The Fall Lecture Luncheon speaker in Mr. and Mrs. Thomas Slick Moorman Mr. and Mrs. Peter C. Selig Mr. and Mrs. Mark E. Watson, Jr. of the scientific work November 2016 was Dr. Suzanne Dabbous with Avestée Women’s Imaging Center Mrs. Jeffrey M. Morehouse Sendero Wealth Management Mr. and Mrs. Rad Weaver being done, as well as Mr. and Mrs. John Moses Dr. and Mrs. Antonio Serna IV Mr. and Mrs. Dan G. Webster III of Alamo Heights speaking on, “The Current State of Screening Mammography.” Mr. and Mrs. Jamie B. Musselman Mr. Carl Sewell Mr. Alex P. Weekes contribute significant Dr. Dabbous is a Past President and Past Gala Chair of the Forum. Our Spring Lecture Ms. Virginia S. Nicholas Mr. and Mrs. Donnie Shaffer Mr. and Mrs. Ronald B. Weiss funding for pilot studies. Luncheon in March 2017 featured Dr. Ricardo Carrion from Texas Biomed, addressing Mr. and Mrs. David F. Nicolson III Dr. and Mrs. R. Mark Sharp Mr. and Mrs. C. Clark Welder the “Development of Vaccines and Therapies to Ebolavirus Disease.” We continue to be Dr. and Mrs. Aris Nikas Mr. and Mrs. Robert Eric Shaw Mr. and Mrs. Heath Wenrich grateful for everyone’s participation and presence at these events. Mr. and Mrs. John A. Oberman Mrs. Clara Shovlin Ms. Kittie West Our 23rd annual Science Education Awards winners included two first place teachers – Rachael Guillen from Young Mr. and Mrs. Keith O’Connell Mrs. E. R. Sidwell Mr. and Mrs. Jason Westmoreland Women’s Leadership Academy for “Using DNA Technology to Research Genealogy” and Jose Ayala from Brooks Academy Mr. and Mrs. Lawrence O’Connor Silver Eagle Distributors, L.P. Mr. Adam Wetherell of Science and Engineering for “Hunting for New Antibiotics in the Wild”; second place went to Jennifer Rice from John Mr. and Mrs. Kirk Oden Mr. and Mrs. Pete Sitterle Mr. and Mrs. Edward E. Whitacre, Jr. Marshall High School for “Forensic Anthropology: Identifying Skeletal Remains” and third place went to Sarah Thompson Mr. and Mrs. Steven M. Ogle Mr. Charles Slick, Jr. Mr. and Mrs. John H. White, Jr. O’Kelley-Hemminghaus Foundation Mr. and Mrs. Bruce A. Smith Mr. and Mrs. Jack Williams III from Earl Warren High School for “A Look Inside: Using Preserved Specimens to Further Aquatic Learning.” These awards Mrs. Frederic J. Oppenheimer Mr. and Mrs. Chad Smith Mr. and Mrs. Scott Wilson are generously supported by Mrs. Valerie Guenther and the V.H. McNutt Memorial Foundation, along with the Forum. Mrs. Susan Oppenheimer Smith Protective Services Mr. and Mrs. Thomas A. Wirth Texas Biomed provided scientific support in evaluating award submissions. In addition to the awards, seven area high Orville Carr Associates, Inc. Mr. and Mrs. James B. Smith, Jr. Mr. and Mrs. Thomas F. Woodley schools toured Texas Biomed this year from all over San Antonio – Warren High School, San Antonio Christian School, Mr. and Mrs. William B. Osborn III Smothers Foundation Wortham Insurance & Risk Management Southside High School, St. Anthony Catholic High School, Poteet High School, Cornerstone Christian School and Jay Dr. and Mrs. Paul D. Pace Mr. and Mrs. John E. Smothers Mr. and Mrs. John G. Wright Science and Engineering Academy. Mr. and Mrs. John Park Mr. and Mrs. Gerry A. Solcher Mrs. Leon C. Wulfe, Jr. The Forum enjoyed several special events this year – the annual Gala Kickoff Luncheon at The Argyle, Past Presidents Mrs. William A. Parker South Texas Money Management, Ltd. Dr. and Mrs. James W. Yancy Luncheon that included our Past Gala Chairs and Co-Chairs this year at the home of Suzanne Dabbous; Board Trustees Mr. and Mrs. George Parker, Jr. Southwest Research Institute Mr. and Mrs. John M. Yantis Christmas Cocktail Party at the home of Karen Lee Zachry; Spring Jewelry Show Luncheon at Saks Fifth Avenue; first Dr. and Mrs. Mahendra Patel Mr. and Mrs. Edward William Spalten Young Presidents Organization Mr. and Mrs. Henry B. Paup Ms. Margo Spitz Marbut Mr. and Mrs. Peter Zacher ever Neiman Marcus – Jefferson Bank Stiletto Strut honoring our annual Gala Fashion Show held at The Argyle; Mrs. Tom E. Pawel Mr. and Mrs. Dennis W. Stacy Zachry Industrial, Inc. annual Board Trustee/Past Presidents Luncheon at the end of the year and last, but certainly not least, our much- Mr. and Mrs. Gardner Peavy Mr. and Mrs. Sam Bell Steves III Mr. and Mrs. H. Bartell Zachry, Jr. anticipated Forum Gala 2017: In Bloom, which took place on the first Saturday in May as has been our tradition. Dr. and Mrs. Daniel C. Peavy Mrs. Marshall T. Steves, Sr. Mr. and Mrs. Joshua Zeller It was an incredible success! Mr. Leo F. Perron, Jr. Mr. and Mrs. S. Van Stewart Mr. and Mrs. Thad W. Ziegler Texas Biomed is a true treasure in our community, and the Forum takes time to educate our community about the Mr. and Mrs. Christopher Petty Mr. and Mrs. Julian C. Stewart Mrs. F. Peter Zoch III importance of the scientific work being done, as well as contribute significant funding for pilot studies. In the last 17

22 23 2016 Founder’s Council

he Founder’s Council is a dynamic group of individuals between the ages Pictured above from left to right: Amanda Besner, Forum President; Sara Walker, Gala Chair; Dr. Jamo Rubin, Texas Biomed of 25 and 46 with the goal of building awareness among our city’s young Chairman; Judy Lutz, Gala Co-Chair; Elizabeth Cox, Gala Assistant. T leaders and creating long-term philanthropic supporters for Texas Biomed. The Founder’s Council was established in 1988 and now boasts more than The Forum awarded $300,000 in grants to scientists at Texas Biomedical Research Institute to assist in developing 330 members from across San Antonio. Members’ annual donations help fund preliminary data that will enable these scientists to secure future funding for novel projects. The following projects were competitive grants to Texas Biomed scientists, and their outreach in the community funded in 2016. is of great value as we seek to encourage more young professionals to become advocates for scientific research. Collaborative Grant: Towards a cure for AIDS in the SIV/rhesus macaque model Dr. Luis Giavedoni, Texas Biomed and Dr. Zhao Lai, UTHealth San Antonio 2016 was a signature year as we celebrated the 75th anniversary of Texas Biomed and the 60th anniversary of The Argyle. With strong membership intact, we focused Liver and serum metabolomics biomarkers for atherosclerosis on educating our members about the opportunity to increase their participation Dr. B. Misra Biswapriya Founder’s Council level to the Adventurer Level of $500 and the Explorer Level of $1,000. We believe this is the greatest way to increase our year-end grant levels and to build long-term Cellular long non-coding RNAs in HIV replication gives members the supporters of Texas Biomed. Dr. Smita Kulkarni opportunity to meet In May we organized a full bus of prospects for the Adventurer and Explorer levels and took a tour of Texas Biomed followed by an intimate dinner and presentation Assessing the impact of consumption of a sugar-sweetened drink on physical activity, body fat, and learn from and metabolism in the baboon on-site by our scientists at Texas Biomed. It was a fantastic evening where many saw the campus and research facilities for the first time. We believe this made a lasting Dr. Anthony Comuzzie the scientists. impact on all guests and drove new members to Founder’s Council. Identification of microRNA biomarkers associated with extent of atherosclerosis in Hispanic obese adolescents To celebrate the anniversary year we hosted our signature event for our higher donors Dr. Genesio Karere on the lawn of The Argyle in October. The evening boasted a wonderful meal and band and the atmosphere was perfect to celebrate and thank our largest Corporate, Explorer and Adventurer donors. Novel antiviral based on crosslinking Marburgvirus nucleoprotein Dr. Andrew Hayhurst We continued to deliver three excellent Lecture Luncheons throughout the year at The Argyle where our scientists shared their cutting edge research with our members and many new prospects. In March, members enjoyed the premiere event, Development of Novel Arenavirus Inhibitors into drug like substances Dining and Discourse, where scientists from across all areas of research joined a table of guests in an intimate setting over Dr. Manu Anantpadma dinner allowing for conversations about their area of expertise. We concluded our 2016 at the Tobin Estate for our annual holiday party and were honored to present the scientists with their equipment grant awards for the year totaling nearly $80,000. years, the Forum has awarded about $3 million to fund these studies. As a result, scientists have been awarded nearly Founder’s Council exists to allow members the opportunity to meet and learn from the scientists, share what they’ve $60 million of additional funds to continue their work! learned in the community and then support these scientific discoveries financially. We believe 2016 played a vital role in We know the Forum would not be where it is without the leadership that came before us. There have been 42 Past helping Texas Biomed make a global impact, and we are proud to carry on this great tradition. Presidents, and we are grateful for their continued support and participation in our hard-working organization. It has been Sincerely yours, my honor to serve as this year’s President and I look forward for the years to come for the Texas Biomedical Forum, an organization dear to my heart. With gratitude and in service, Jeff P. Bailey 2016 President, Founder’s Council

Daniela Serna 2016 Forum President

24 25 2016 The Founder’s Council

EXPLORER MEMBERS ADVENTURE MEMBERS Hixon Properties, Inc. GENERAL MEMBERS Mr. Adam Harden Mr. Hunter Kingman Mr. and Mrs. Shawn Hatter Mr. Barclay C. Adams Mr. and Mrs. Omar Akhil Mr. Clint Wynn Ms. Selena Aleman Mr. and Mrs. Brett Alvheim Mr. Suhail Arastu Mr. David M. Altgelt Mr. and Mrs. Clay Hefty Hornberger Fuller & Garza, Inc. Mr. and Mrs. Roger C. Hill III Mr. Aaron Asel Mr. and Mrs. Edward Badouh Mrs. Elizabeth Fry Mr. and Mrs. David Alvarez Mr. and Mrs. Edward Badouh III Ms. Carlie L. Hill Mr. and Mrs. Brian and Emmy Ballantyne Mr. & Mrs. Cliff Hurd Dr. and Mrs. Garrett K. Andersen Mr. and Mrs. Jeff P. Bailey Mr. and Mrs. David Hornberger Mr. and Mrs. John Brozovich Independence Title Company Mr. Charles Anderson Mr. and Mrs. Matthew M. Bell Mr. and Mrs. Kenneth Dorbandt Ms. Rebecca Bagby Mr. Suhail Arastu Mr. and Mrs. Lawson Jessee Mr. and Mrs. Ryan Berg Mr. and Mrs. David Gard Mrs. Lara Thompson Mr. and Mrs. Inigo Arzac Mr. and Mrs. Clyde J.B. Johnson IV Dr. Edward Briggs and Dr. Sara McCamish Mr. and Mrs. James Griffin Jackson Walker, LLP Ms. Katherine Atkinson Dr. Joe Johnston Mr. J. Craig Browning, Jr. Mr. and Mrs. Jeffrey F. Hetrick Mrs. Lauren Cimenello Mr. John Ballantyne Mr. and Mrs. Jacob Jones Mr. and Mrs. John Brozovich Ms. Alexine Friedman Mr. George Hinchey Mr. and Mrs. Chris Kardys Mr. and Mrs. Claiborne Ayres Carrington Mr. Colton H. Batchelor J.P. Morgan & Company Mr. and Mrs. Tim Kelley Mr. and Mrs. Justin Cole Mr. and Mrs. Daniel Koehl Mr. and Mrs. Brad Beldon Mr. Jeff Bailey Ms. Millie Kerr Mr. and Mrs. Joshua Crumpton Mr. and Mrs. William Kothmann Ms. Michele Camp Mr. and Mrs. Robert Berry Mr. Faisal David Khan Mr. and Mrs. Trey Dawson Mr. and Mrs. Daniel Lasater Mauze Construction Mr. Charles O. Biedenharn, Jr. Mr. and Mrs. Jeffrey de Rojas Mr. and Mrs. Alcide M. Longoria Mr. David Mauze Mr. Chris A. Blasko Mr. and Mrs. Daniel Koehl Mr. and Mrs. Christopher H. Dewar Mr. & Mrs. David McArthur McNelis + Associates, PLLC Mr. Sean M. Blasko Mr. and Mrs. Matthew Koehler Mr. and Mrs. John W. Feik, Jr. Mr. and Mrs. Robert McRae Mr. Sean McNeils Dr. Emily Boice Mr. and Mrs. Claude K. Koontz Mr. and Mrs. Ron Finch Mr. and Mrs. Paul Rohlfs, Jr. Mr. Richard McSwain Mr. Kyle Braaten Ms. Stephanie Krueger Mr. and Mrs. Casey Fry Mr. and Mrs. Robert Shaw Mission Title Mr. and Mrs. Ben Bratteli Mr. and Mrs. James F. Lane Mr. and Mrs. James B. Gouger Mr. and Mrs. R. Bruce Walker Mr. Walter Simpson Mr. and Mrs. Clint Lawson Mr. Gregg Lyssy Mr. and Mrs. Keith Brittain Mr. and Mrs. Jack E. Guenther, Jr. Dr. Alexis Wiesenthal Mr. and Mrs. William Brooks Mrs. Brooke Leddy Mr. and Mrs. Daniel Hargrove Nelson Puett Foundation Mr. and Mrs. John H. Wright IV Mr. Jeffrey Brouillard Mr. Juan Leon Mr. and Mrs. Jeffrey Heinke Mrs. Callie Price Mr. Steven F. Willson Ms. Jennifer Brown Mr. and Mrs. Colby Lewis Mr. and Mrs. David S. Herrmann Pape-Dawson Engineers, Inc. Dr. and Mrs. John Browning, Sr. Mr. and Mrs. Mark Lewis Mr. Jonathan Hess Mr. Taylor Dawson CORPORATE AND Mr. Trey Dawson Mr. David Lloyd Mr. and Mrs. Timo Hixon SPONSOR MEMBERS Mr. and Mrs. Randy Cadwallader Project Control of Texas, Inc. Mr. and Mrs. Alcide Longoria Mr. and Mrs. Charles R. Hollimon Ms. Michelle Camp Asel & Associates, PLLC Mr. John Duhring Mr. Jay Lucas Mr. and Mrs. Anthony C. Johnson Mr. Aaron Asel Mr. Andrew Cardwell Mr. Andrew Hunt Mr. and Mrs. Alex McAllister Mr. and Mrs. Brad Jones Mr. John Asel Mr. Paul B. Carter R.L. Worth & Associates Mr. Andrew McAllister Mr. and Mrs. Creston A. King III BB&T Mrs. Jordan Arriaga Mr. and Mrs. James Chandler Mr. Benjamin Montanez Mr. and Mrs. Travis Kowalski Mrs. Stephanie Dick Mr. Clint Worth Mr. Scott A. Christy Mr. and Mrs. Johnny Moorman Mr. and Mrs. Byron L. LeFlore, Jr. Mr. Ben Pressentin RSM US LLP Mr. and Mrs. Brandon Clementson Mr. and Mrs. Taylor Little Broadway Bank Ms. Josie Behrend Mr. and Mrs. Hunter Conger Mr. Moses Moorman Ms. Nena M. Scott Ms. Tammy Ashby Mr. and Mrs. Charles G. Martens Mrs. Vicky Martin Mr. Carl and Dr. Megan Crane Ms. Mary Christian Moorman Mr. and Mrs. Forrest Seger Mr. Travis Edlund Mr. and Mrs. David Mauze RVK Architects Mr. Andrew R. Craig Mr. Zachary Moorman Mr. and Mrs. Robert Webb Sellers Brown & Ortiz, PC Mr. Jason Puchot Mr. and Mrs. Madison Mauze Drs. Matthew and Ann Cross Ms. Catriona L. Morrison Ms. Abigail Shaver Mr. and Mrs. Norris Robert McClane Mr. James Griffin Mr. Heath Wenrich Mr. and Mrs. Ryan David Mr. Mark Muecke Mr. Ty Hunter Sheehan Mr. and Mrs. Sean McNelis Cappy’s, Inc. & La Fonda, Inc. Sendero Wealth Management Dr. John DeKock and Dr. Annie Rothe Mr. Keith O’Connell Ms. Lindsey Wilkinson Shumway Mr. and Mrs. Joe Miller Mr. Trevor Lawton Ms. Ann Buckthal Ms. Regina Rocha Mr. and Mrs. Joseph P. O’Connor Dr. Gurpaul Singh Mr. and Mrs. John R. Moses Ms. Kokila Muthukumar Mr. and Mrs. Miguel Dilley Mr. and Mrs. Lawrence O’Connor Mr. and Mrs. Alan Spalten Mr. and Mrs. Matthew Z. Mosser Cavender Auto Group Silver Eagle Distributors Mr. and Mrs. Albert Dickson Mr. Lee Cavender Mr. and Mrs. Kirk Oden Mr. and Mrs. William Spalten Mr. and Mrs. Steven M. Ogle Mr. Mark De Hoyas Mr. Kevin Doran Mr. W.B. Cavender Ms. Katy Reynolds Mr. and Mrs. Brian O’Gorman Mr. and Mrs. Matthew Strange Mr. and Mrs. Gardner Peavy Mr. and Mrs. Taylor Dorris Cavender Toyota Mr. and Mrs. Christopher Petty Texas Capital Bank Mr. and Mrs. Robert A. Dullnig Drs. Michael and Claudia Olivier Ms. Delaney Tholen Ms. Kate Cavender Mr. Brandon Kneupper Mr. and Mrs. Andrew B. Price Mr. and Mrs. Eric A. Dupre Mr. and Mrs. H. Mills Palm, Jr. Mr. Charles Clayton Thomas, Jr. Commercial Storage Specialists Mr. David Pope Dr. and Mrs. Antonio Serna IV Mr. Robert C. Ehlers and Mr. and Mrs. Donald R. Philbin, Jr. Mr. and Mrs. Frederick Thomson IV Ms. Natalie Harrison The Bank of San Antonio Mr. Benjamin Pilgrim Mr. and Mrs. Adam Vielock Mr. Charles Slick, Jr. Mr. Johnny Moorman Mr. Jordan Booth Dr. Silvia Santinelli Mr. and Mrs. Sam Steves III DuWest Realty Ms. Kacy Smith Mr. Will Fawcett Mr. Phillip Plant, Jr. Mr. and Mrs. Robert Watson, Jr. Dr. and Mrs. Norton A. Stuart III Mr. Evan Ketabchi The Tobin Endowment Mr. Ramiro Fernandez and Ms. Ashley Ross Mr. and Mrs. Jack Marshall Porterfield Ms. Trudie Weatherford Ms. Shelley M. Summers Mr. Brian Smith Wortham Insurance Risk Management Mr. and Mrs. Robert Flannery Ms. Jenna Monette Reblin Mr. and Mrs. William Daniel Westmoreland Dr. and Mrs. George J. Vassar Dykema Cox Smith Mrs. Katherine Loftin Mr. and Mrs. Andrew T. Friedman Mr. Krishna Reddy Mr. and Mrs. Marc Whyte Mr. and Mrs. Rad Weaver Mr. Ray Bissmeyer Mr. Eric Smith Ms. Alexine Friedman Mr. and Mrs. J.B. Richter Mr. Jon Wiegand Ms. Erin Jansen Mr. and Mrs. C. Clark Welder Yantis Company Mr. Houston Frost Mrs. Carla Martinez Riedl Mr. and Mrs. Brandon Williams Mr. and Mrs. Jason Westmoreland Frost Mr. Todd Compton Ms. Lauren Geraghty Mrs. Cari Robinson Mr. and Mrs. George J. Wommack Mr. and Mrs. Adam Wetherell Mrs. Mallory Ahl Mr. Mike Yantis Mr. and Mrs. Matthew Gish Mr. Wallace Rogers IV Mr. and Mrs. Elgin Wong Mr. and Mrs. Robert Clinton Worth Mrs. Mary Stephanie Locke Zachry Group Ms. Lauren Gordon Mr. and Mrs. Patrick Rouse Mr. and Mrs. Will F. Ziegler Mr. and Mrs. Peter Zacher Guido Brothers Construction Mr. Rode Moore Mr. Robert Foster and Ms. Mary Rowe Mr. Frank Zoch Mr. and Mrs. Joshua Zeller Mr. Cosmo Guido Mr. David Schwab Mr. and Mrs. Ricardo Guzman

26 27 The Argyle

his year, The Argyle celebrated For 60 years, this historic In partnership with Texas Biomed, The new coffee and tea program for members. Coperaco was Ruprecht discussing an innovative approach to vaccine its 60th anniversary as the Southern mansion and Argyle hosted a grand anniversary party chosen to design our new coffee program. It is a boutique development in the fight against HIV in early 2016. T establishment of an exceptional for its members on November 17, 2016, company whose mission is to upgrade coffee into a true In June, as news of Zika virus gained international club whose members contribute to the unique private club that again served as an opportunity to culinary product. Tea Forté is our new tea company and attention and the virus began to spread to the U.S., mission of Texas Biomed, which is to has supported the educate the community about the work is considered to be among the top 1% of all tea companies Dr. Jean Patterson discussed studies underway at unravel the mysteries of chronic and of Texas Biomed and thank all those who because they only use the top two leaves of the Camellia Texas Biomed to understand the virus and its infectious diseases through innovative life-saving efforts of have supported both organizations over Sinensis, the tea plant. The Argyle has also partnered with sometimes devastating consequences on newborns. thinking, creative problem solving and Texas Biomedical the years. The celebration underscored the Amici Winery in Napa and developed our own label In October, Dr. Robert Lanford updated our members cutting-edge technologies. Research Institute. that The Argyle is still a unique and of white and red blend wines called 934 Patterson Ave. on studies underway at the Southwest National important symbol of the community’s Primate Research Center into Hepatitis C, liver In 1954, Tom Slick Jr.’s sister, Betty rich past and of the progress that people The Argyle continued to host many splendid occasions disease, pertussis, and other research initiatives at Slick Moorman devised the idea to turn can make together toward a better tomorrow for mankind. such as weddings and family events. In addition to the the Center. a dilapidated horse ranch into a place that could serve both financial support members provide Texas Biomed, the community and her brother’s vision. With the support The Argyle’s commitment to excellence continues today. The Argyle hosted community education events, including “Fireside Chats” allow members and their guests to and help of her husband Lew Moorman and many others Members welcomed many changes within the facility in its most popular initiative called “Fireside Chats.” meet with Texas Biomed scientists in a social setting in the community, The Argyle was restored and opened 2016, several of which were behind the scenes, including to enjoy a conversational exchange of ideas, including in 1956. Today, The Argyle serves as a bond between updates to the kitchen floor, a new dining reservation Last year’s “Fireside Chats” included Dr. Marcel Daadi and the opportunity for questions and answers regarding scientists and the men and women who have dedicated system and new pager system for the servers. Several new Dr. Roy Choudary providing an update on stem cell the scientists’ research. It is a true bridge builder personal resources for the advancement of science. beverage programs were introduced in 2016 to include a treatment studies for neurological disorders and Dr. Ruth between the scientists and supporters. Financials

2016 Revenue*

49.1% Grants 19.2% Federal Research Contracts 2.9% Non-Federal Contracts 2.6% Restricted Contributions

5.7% Unrestricted Contributions

14.7% Investment Income

1.6% Royalty Income 4.2% Other Income

* Based on 2016 Audited Financials

2016 Value of Endowment In Millions of Dollars

$120 $117.4 $118.3 $114.6 $111.5

$100.8 $100 $93.2 $91.4

$80 Gabriella Worwa, D.V.M., Ph.D., works in the biosafety level 4 laboratory, which is designed for maximum safety allowing for research of the world’s deadliest infections. In June 2017, Texas Biomedical Research Institute’s Board of Trustees $60 approved moving forward with the design and 2010 2011 2012 2013 2014 2015 2016 construction of a new biosafety level 4 facility. To learn more about this late-breaking news, please visit www.txbiomed.org.

30 PHILANTHROPIC RESEARCH GRANTS PRINCIPAL NEW AWARD Grants And Contracts SPONSOR TITLE INVESTIGATOR LENGTH TOTAL Various Community Awareness Campaign Various investigators 1 year $1,149,135 Awarded in 2016 Texas Biomedical Towards a cure for AIDS in the SIV/rhesus macaque model Dr. Luis D. Giavedoni 1 year $310,00 Forum and Dr. Zhao Lai RESEARCH Liver and serum metabolomics biomarkers for atherosclerosis Dr. B. Misra Biswapriya Cellular long non-coding RNAs in HIV replication Dr. Smita Kulkarni COMMERCIAL RESEARCH GRANTS Total from Commercial Research $1,350,093 Assessing the impact of consumption of a sugar-sweetened drink on Dr. Anthony Comuzzie FEDERAL RESEARCH GRANTS physical activity, body fat, and metabolism in the baboon NEW AWARD Identification of microRNA biomarkers associated with extent of Dr. Genesio Karere SPONSOR TITLE PRINCIPAL INVESTIGATOR LENGTH TOTAL atherosclerosis in Hispanic obese adolescents NIH Southwest National Primate Research Center Dr. Larry Schlesinger 5 years $40,136,909 Novel antiviral based on crosslinking Marburgvirus nucleoprotein Dr. Andrew Hayhurst Development of Novel Arenavirus Inhibitors into drug like substances Dr. Manu Anantpadma NIH Defense-in-depth Against Mucosal HIV Clade C Invasion Dr. Ruth Ruprecht 5 years $23,153,411 Microbiome Nutrition and Obesity Research Study Dr. Michael Olivier NIH/WUSL Structural and Functional Characterization of the Ebola Virus Dr. Robert Davey 5 years $3,567,190 Texas Biomedical 15 grants for laboratory equipment Various 1 year $80,048 Replication Complex Founder’s Council NIH/BATTELLE Evaluation of Filovirus Vaccines in a General Use Prophylaxis (GUP) Dr. Ricardo Carrion 2 years $2,881,033 MARMION J.T. Marmion MS Pilot Studies Dr. Marcel Daadi 1 year $238,395 Immunogenicity and Ebolavirus Challenge Studies to Identify Potential COWLES Assessing MicroRNA Function for Therapeutic Advancement in Dr. Ashish Kumar 1 year $113,521 Correlates of Protection Bipolar Disorder KLEBERG/UTEP Novel Vaccine for Chagas Disease: Efficacy Testing in Baboons Dr. Karen Rice 1 year $108,546 NIH Research to Improve and Standardize Marmoset Nutrition and Dietary Dr. Suzette Tardif 4 years $2,796,902 VOELCKER/CHOSA The Role of Follistatin Like 1 Protein in Coronary Artery Aneurysms of Dr. Jean Patterson 1 year $95,301 Husbandry Kawasaki disease BARDA/IITRI Efficacy Study of mAb Therapeutics Against Lethal Challenge of Nonhuman Dr. Ricardo Carrion 1 year $2,002,125 William and Ella Owens Derivation of muscle precursors from human pluripotent stem cells to Dr. Tiziano Barberi 1 year $90,000 Primates with EBOV Medical Research Foundation transplant in a dog model of Duchenne muscular dystrophy William and Ella Owens DOD In vitro and in vivo Characterization of Filoviruses through the Exploration Dr. Anthony Griffiths 1 year $1,568,646 Stem cell treatment for diabetes Dr. Marcel Daadi 1 year $90,000 Medical Research Foundation of Various Vaccine Candidates William and Ella Owens Improving vaccine effectiveness: the use of combined cytokines to enhance Dr. Vida Hodara 1 year $57,884 DTRA/SwRI Cepharanthine/Chloroquine Combination for Prophylaxis or Treatment of Ebola Dr. Robert Davey 1 year $1,352,021 Medical Research Foundation immune response to vaccines NIH/BAV NOR Development of Technologies that Accelerate the Immune Response to Biodefense Dr. Ricardo Carrion 1 year $1,188,232 COWLES Determining the Effects of Amino Acid Substitution in the Signal Peptide of Dr. Kendra Alfson 1 year $55,645 Vaccines (Part 14) (Jean Patterson, Co-PI) Marburg Virus Glycoprotein on biogenesis and Trafficking of the Glycoprotein TOPS TOPS Nutrition and Obesity Research Center Dr. Michael Olivier 1 year $50,000 NIH/BATTELLE Efficacy Testing of Filovirus Vaccines in Nonhuman Primates Dr. Jean Patterson 1 year $1,153,551 William and Ella Owens Characterization of Ebola virus defective viral genomes and their impact Dr. Beata Boczkowska 1 year $46,887 (Ricardo Carrion, Jr., Anthony Griffiths - Co-PI) Medical Research Foundation on the innate immune response BARDA/IITRI Efficacy Studies of a Monoclonal Antibody Cocktail Against Lethal Challenges Dr. Ricardo Carrion 1 year $905,526 CRUMP Identification of novel mediators of gene silencing in lung cancer Dr. Hector Guillen 1 year $35,000 of Nonhuman Primates with EBOV SAAF Identifying causes of increased fracture risk in individuals with diabetes Dr. Ellen Quillen 1 year $33,700 NIH Development of Technologies that Accelerate the Immune Response to Biodefense Dr. Ricardo Carrion 1 year $689,452 Total from Philanthropic Research $2,269,291 Vaccines (Part 13) (Jean Patterson, Co-PI) UNIVERSITY RESEARCH GRANTS NEW AWARD SPONSOR TITLE PRINCIPAL INVESTIGATOR LENGTH TOTAL NIH/JANSSEN Advanced Development of a Multivalent Filovirus (Ebola/Marburg) Dr. Ricardo Carrion 1 year $638,145 Hemorrhagic Fever Vaccine (SOW 24 v2) UTHSCSA Anticonvulsive Effect of VNS in the Epileptic Baboon Dr. Karen Rice 1 year $53,848 NIH Identification of Molecular Mechanisms Underlying Early Atherosclerosis Dr. Genesio Karere 5 years $630,460 Total from University Research $53,848 NIH/JANSSEN Advanced Development of a Multivalent Filovirus (Ebola/Marburg) Dr. Ricardo Carrion 1 year $537,775 TOTAL FROM RESEARCH $88,619,063 Hemorrhagic Fever Vaccine (SOW 23 v2) CAPITAL NIH Functional Impact of Long Non-coding RNA Expression on HIV Control Dr. Smita Kulkarni 2 years $420,679 FEDERAL NIH/Collab. Repurposing pyronaridine as a treatment for the Ebola virus Dr. Robert Davey 2 years $334,533 NEW AWARD SPONSOR TITLE PRINCIPAL INVESTIGATOR LENGTH TOTAL

NIH/WAKE Prenatal Events, Postnatal Consequences Dr. Laura Cox 1 year $267,603 NIH Southwest National Primate Research Center-Supplement Dr. Robert Lanford 1 year $401,280 FDA Bordetella-Free Weanling Baboons Dr. Karen Rice 1 year $256,620 Total from Federal Capital $401,280 DOD Optimizing the Adaptation of SHIV-E: Re-isolation of an R5-tropic Dr. Ruth Ruprecht 1 year $125,000 PHILANTHROPIC NEW AWARD Pathogenic Virus SPONSOR TITLE PRINCIPAL INVESTIGATOR LENGTH TOTAL

NIAID/TSRI Cooperative Center for the study of HCV antibody responses and vaccine Dr. Robert Lanford 1 year $124,709 McNutt V. H. McNutt Memorial Foundation Gang Cages Donation Matthew Majors 1 year $25,000 ARMY/UTHSCSA CAP: Genetic and Epigenetic Alterations as Biomarkers for PTSD Diagnosis Dr. Melanie Carless 2 years $119,862 Total from Philanthropic Capital $25,000 and Prognosis TOTAL FROM CAPITAL $426,280 NIH/UTRGV 2/2 An Integrative Genetic Investigation of Schizophrenia Dr. Eugene Drigalenko 1 year $59,404 DARPA/Harvard Species Inspired Research for Innovative Treatments (SPIRIT) Dr. Robert Lanford 2 years $36,042 GRAND TOTAL OF NEW GRANTS AND CONTRACTS AWARDED $89,045,343 Total from Federal Research $84,945,831

32 33 Acknowledgments

Officers of the Institution and Senior Administrators

President and Chief Executive Officer Vice President, Research Chief Information Officer Larry S. Schlesinger, M.D. Joanne Turner, Ph.D. Brian Bounds Vice President for Finance and Vice President, Advancement Assistant Vice President, Operations Administration, Chief Financial Officer and Public Relations Matthew Majors Keith A. Davis Corbett Christie

Senior Scientific Leadership Team

Interim Chair, Department of Genetics Interim Chair, Department of Director, Southwest National Timothy Anderson, Ph.D. Virology & Immunology Primate Research Center Luis Giavedoni, Ph.D. Robert Lanford, Ph.D.

Copyright © 2017 CREDITS IMAGES Texas Biomedical Research Institute Lisa Cruz, Greg Harrison, Photographer pp 16-17 P.O. Box 760549 Texas Biomed Director of Jeffrey Heinke, p. 4-5 San Antonio, Texas 78245 Public Relations, Editor Josh Hushkin, Photographer for Progress The 2016 Annual Report is a publication of Jeffrey Heinke Design, Photo courtesy of Daniela Serna, p. 23 the Texas Biomedical Research Institute. Design *Board of Trustees and Senior Administrators Photo courtesy of Jeff Bailey, p. 25 listed for 2017 File photos, all other pages

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