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(12) United States Patent (10) Patent No.: US 8,771,755 B2 Gojon-Romanillos Et Al

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(12) United States Patent (10) Patent No.: US 8,771,755 B2 Gojon-Romanillos Et Al US008.771755B2 (12) United States Patent (10) Patent No.: US 8,771,755 B2 Gojon-Romanillos et al. (45) Date of Patent: Jul. 8, 2014 (54) PREPARATION AND COMPOSITIONS OF International Search Report and Written Opinion for International HIGHLY BOAVAILABLE ZEROVALENT Application No. PCT/MX12/00086, mailed Mar. 27, 2013. Abdolrasulnia et al., “Transfer of persulfide sulfur from thiocystine to SULFUR AND USES THEREOF rhodanese.” Biochim. Biophys. Acta. 567:135-143, 1979 (Abstract only). (75) Inventors: Gabriel Gojon-Romanillos, San Pedro Abe et al., “The Possible Role of Hydrogen Sulfide as an Endogenous Garza García (MX); Gabriel Neuromodulator.” The Journal of Neuroscience 16:1066-1071, 1996. Gojon-Zorrilla, San Pedro Garza García Agarwal et al., “Clinical Relevance of Oxidative Stress in Male Factor Infertility: An Update.” American Journal of Reproductive (MX) Immunology 59:2-11, 2008. Agarwal et al., “Oxidative stress and antioxidants for idiopathic (73) Assignee: Nuevas Alternativas Naturales, S.A.P.I. oligoasthenoteratospermia: Is it justified?” Indian J. Urol. 27:74-85, de C.V., Monterrey (MX) 2011 (Abstract only). Agarwal et al., “Oxidative stress and antioxidants in male infertility: (*) Notice: Subject to any disclaimer, the term of this a difficult balance.” Iranian Journal of Reproductive Medicine3: 1-8, patent is extended or adjusted under 35 2005. U.S.C. 154(b) by 0 days. Agarwal et al., “Role of Oxidative Stress in the Pathophysiological Mechanism of Erectile Dysfunction.” Journal of Andrology 27:335 347, 2006. (21) Appl. No.: 13/614,820 Aggarwal, "Nuclear factor-KB:The enemy within.” Cancer Cell 6:203-208, 2004. (22) Filed: Sep. 13, 2012 Aggarwal et al., “Inflammation and Cancer. How Friendly is the Relationship for Cancer Patients?” Curr: Opin. Pharmacol. 9:351 (65) Prior Publication Data 369, 2009. Aggarwal et al., “Signal Transducer and Activator of Transcription-3, US 2013/OO64904 A1 Mar. 14, 2013 Inflammation, and Cancer. How Intimate Is the Relationship?.” Ann. N.Y. Acad. Sci. 1171:59-76, 2009. Aggarwal et al., “Targeting Inflammatory Pathways for Prevention Related U.S. Application Data and Therapy of Cancer: Short-Term Friend, Long-Term Foe.” Clin. (60) Provisional application No. 61/534,585, filed on Sep. Cancer Res. 15:425-430, 2009. Aitken et al., “New insights into sperm physiology and pathology.” 14, 2011. Handb. Exp. Pharmacol. 198:99-115, 2010 (Abstract only). Aitken et al., “Redox regulation of human sperm function: from the (51) Int. Cl. physiological control of sperm capacitation to the etiology of infer A6 IK33/04 (2006.01) tility and DNA damage in the germ line.” Antioxid Redox Signal. A6IP 9/00 (2006.01) 14:367-381, 2011 (Abstract only). A6IP 25/28 (2006.01) AlekSunes et al., “Transcriptional Regulation of Renal Cytoprotec tive Genes by Nrf2 and Its Potential Use as a Therapeutic Target to A6IP 29/00 (2006.01) Mitigate Cisplatin-Induced Nephrotoxicity.” J. Pharmacol. Exp. (52) U.S. Cl. Ther: 335:2-12, 2010. USPC ........................................... 424/705:424/703 Anderson et al., “The effects offocalischemia and reperfusion on the (58) Field of Classification Search glutathione content of mitochondria from rat brain Subregions. J. USPC .................................................. 424/703,705 Neurochem. 81:541-549, 2002. Anoush et al., “The Protective Effect of Garlic Extract against See application file for complete search history. Acetaminophen-Induced Loss of Mitochondrial Membrane Potential in Freshly Isolated Rat Hepatocytes.” Iranian Journal of Pharmaceu (56) References Cited tical Sciences 5:141-150, 2009. Antosiewicz et al., “c-Jun NH2-Terminal Kinase Signaling Axis U.S. PATENT DOCUMENTS Regulates Diallyl Trisulfide-Induced Generation of Reactive Oxygen 5,100,653 A 3/1992 Campo Species and Cell Cycle Arrest in Human Prostate Cancer Cells.” 7,741,359 B2 6, 2010 Wallace et al. Cancer Res.66:5379-5386, 2006. 8,361,514 B2 1/2013 Gojon-Romanillos Aruoma et al., “The antioxidant action of taurine, hypotaurine and 8,389,005 B2 3/2013 Gojon-Romanillos their metabolic precursors.” Biochem. J. 256:251-255, 1988. 2002/0132015 A1 9, 2002 Shacknai et al. 2003/0235571 A1 12/2003 Gojon-Romanillos (Continued) 2004/0057.972 A2 3/2004 Shacknai et al. 2008. O1995.41 A1 8, 2008 Tomaselli et al. Primary Examiner — Frederick Krass 2009, O181081 A1 7/2009 Gojon-Romanillos 2009/0304819 A1 12/2009 Gojon-Romanillos Assistant Examiner — Tracy Liu 2011/O195945 A1 8/2011 Ruan et al. (74) Attorney, Agent, or Firm — Clark & Elbing LLP 2012/0135091 A1 5, 2012 Roth et al. (57) ABSTRACT FOREIGN PATENT DOCUMENTS The present invention features Sulfur-rich compositions and EP O242553 A1 10, 1987 preparations thereof that are safe and effective as hydrogen RU 24O6477 C1 12/2010 sulfide prodrugs of high bioavailability. The invention also WO WO-2009004082 A2 1, 2009 includes methods of treating pathological conditions associ WO WO-2010O29021 A1 3, 2010 ated with oxidative stress using Sulfur-rich compositions. The WO WO-2012O75242 A2 6, 2012 invention further includes Sulfur-rich compositions as anti OTHER PUBLICATIONS dotes and medical food for preserving and promoting general health. International Search Report and Written Opinion for International Application No. PCT/US 12/55205, mailed Nov. 20, 2012. 4 Claims, 27 Drawing Sheets US 8,771,755 B2 Page 2 (56) References Cited Blouet et al., “Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance.’ Free Radic. Biol. Med. 42: 1089-1097, OTHER PUBLICATIONS 2007 (Abstract only). Asano et al., “Aging influences multiple indices of oxidative stress in Blumentals et al., “Role of Polysulfides in Reduction of Elemental the heart of the Fischer 344/NNia X Brown Norway/BiNia rat.” Sulfur by the Hyperthermophilic Archaebacterium Pyrococcus Redox. Rep. 12:167-180, 2007 (Abstract only). furiosus," Applied and Environmental Microbiology 56: 1255 Badaloo et al., “Cysteine Supplementation improves the erythrocyte 1262, 1990. glutathione synthesis rate in children with severe edematous malnu Bordo et al., “The rhodanese/Cdc25 phosphatase Superfamily: trition. Am. J. Clin. Nutr. 76:646-652, 2002. Sequence-structure-function relations.” EMBO Reports 3:741-746, Bagnato et al., "Clinical improvement and serum amino acid levels 2002. after mud-baththerapy.” Int. J. Clin. Pharmacol. Res. 24:39-47, 2004 Bos et al., “Hydrogen Sulfide-Induced Hypometabolism Prevents (Abstract only). Renal Ischemia/Reperfusion Injury.” J. Am. Soc. Nephrol. 20:1901 Balaban et al., “Delivery of the bioactive gas hydrogen sulfide during 1905, 2009. cold preservation of ratliver: effects on hepatic function in an ex vivo Bouckenooghe et al., “Istaurine a functional nutrient?.” Curr: Opin. model.” Artif. Organs 35:508-515, 2011 (Abstract only). Clin. Nutr. Metab. Care, 9:728-733, 2006 (Abstract only). Ballatori et al., “Glutathione dysregulation and the etiology and Bouma et al., “Induction of torpor: mimicking natural metabolic progression of human diseases.” Biol. Chem. 390:191-214, 2009. suppression for biomedical applications.”.J. Cell. Physiol. 227: 1285 Balogh et al., “Effectiveness of balneotherapy in chronic low back 1290, 2012 (Abstract only). pain—a randomized single-blind controlled follow-up study.” Forsch Braga et al., “Antioxidant Effect of Sulphurous Thermal Water on Komplementarmed Klass Naturheilkd 12:196-201, 2005 (Abstract Human Neutrophil Bursts: Chemiluminescence Evaluation.” Respi only). ration 75:193-201, 2008. Ban et al., “Inhibition of Cell Growth and Induction of Apoptosis via Brancaleone et al., “BioSynthesis of H2S is impaired in non-obese Inactivation of NF-kB by a Sulfurcompound Isolated From Garlic in diabetic (NOD) mice.” British Journal of Pharmacology 155:673 Human Colon Cancer Cells. J. Pharmacol. Sci. 104:374-383, 2007. 680, 2008. Bansal et al., “Impacts of Oxidative Stress and Antioxidants on Branzoli et al., “Evidence for an Active Site Persulfide Residue in Semen Functions.” Vet. Med. Int. 2011:1-7, 2011. Rabbit Liver Aldehyde Oxidase.” The Journal of Biological Chem Baskar et al., “Hydrogen Sulfide gas has cell growth regulatory role.” European Journal of Pharmacology 656:5-9, 2011. istry 249:4346-4349, 1974. Baskar et al., “Hydrogen Sulfide-induces DNA damage and changes Breitkreutz et al., “Improvement of immune functions in HIV infec in apoptotic gene expression in human lung fibroblast cells.” The tion by Sulfur supplementation: two randomized trials.” J. Mol. Med. FASEB Journal 21:247-255, 2007. (Berl).78:55-62, 2000 (Abstract only). Baskin et al., “In vitro and in vivo comparison of Sulfur donors as Brigelius-Flohé et al., “Basic Principles and Emerging Concepts in antidotes to acute cyanide intoxication.”.J. Appl. Toxicol. 19:173-183. the Redox Control of Transcription Factors.” Antioxidants & Redox 1999 (Abstract only). Signaling 15:2335-2381, 2011. Bass et al., “Novel Dithiolethione-Modified Nonsteroidal Anti-In Britschka et al., “The efficacy of Brazilian black mud treatment in flammatory Drugs in Human Hepatoma HepG2 and Colon LS180 chronic experimental arthritis.” Rheumatol. Int. 28:39-45, 2007 Cells. Clin. Cancer Res. 15:1964-1972, 2009. (Abstract only). Baumber et al., “Reactive Oxygen Species and Cryopreservation Brosnan et al., “The Sulfur-Containing Amino Acids: An Overview.” Promote DNA Fragmentation in Equine Spermatozoa.” J. Androl. J. Nutr. 136:1636S-1640S, 2006. 24:621-628, 2003. Bruchhausen et al., “Thiol antioxidants block the activation of anti Beck-Speier et al., “Sulfite stimulates NADPH oxidase of human gen-presenting cells by contact sensitizers. J. Invest. Dermatol. neutrophils to produce active oxygen radicals via protein kinase C 121:1039-1044, 2003. and Ca2+/calmodulin pathways.” Free Radic. Biol. Med. 14:661 Bucci et al., “Hydrogen Sulphide in heart and systemic circulation.” 668, 1993 (Abstract only). Inflamm. Allergy Drug Targets 10:103-108, 2011 (Abstract only). Becker et al., “Thioredoxin reductase as a pathophysiological factor Budde et al., “Hydrogen Sulfide Increases Hypoxia-inducible Fac and drug target.” Eur: J. Biochem. 267:6118-6125, 2000. tor-1 Activity Independently of von Hippel-Lindau Tumor Suppres Beinert, “A tribute to sulfur Eur: J. Biochem. 267:5657-5664, 2000.
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